@book{Tietze2010,
  author    = {Tietze, J{\"u}rgen},
  title     = {{\"U}bungsbuch zur angewandten Wirtschaftsmathematik : Aufgaben, Testklausuren und ausf{\"u}hrliche L{\"o}sungen. - 8., {\"u}berarb. und erw. Auflage},
  edition   = {8., {\"u}berarb. und erw. Auflage},
  publisher = {Vieweg + Teubner},
  address   = {Wiesbaden},
  isbn      = {978-3-8348-9706-0 ; 978-3-8348-1236-0},
  pages     = {VIII, 402 S.},
  year      = {2010},
  language  = {de}
}
@book{Tietze2010,
  author    = {Tietze, J{\"u}rgen},
  title     = {Einf{\"u}hrung in die angewandte Wirtschaftsmathematik : das praxisnahe Lehrbuch - bew{\"a}hrt durch seine brillante Darstellung ; mit 1300 {\"U}bungsaufgaben. - 15., {\"u}berarb. und erw. Aufl.},
  edition   = {15., {\"u}berarb. und erw. Aufl.},
  publisher = {Springer},
  address   = {Wiesbaden},
  isbn      = {978-3-8348-0976-6 ; 978-3-8348-9364-2},
  pages     = {XVI, 598 S.},
  year      = {2010},
  language  = {de}
}
@book{Tietze2010,
  author    = {Tietze, J{\"u}rgen},
  title     = {{\"U}bungsbuch zur Finanzmathematik : Aufgaben, Testklausuren und ausf{\"u}hrliche L{\"o}sungen. - 6., aktualisierte Aufl.},
  edition   = {6., aktualisierte Aufl.},
  publisher = {Springer},
  address   = {Wiesbaden},
  isbn      = {978-3-8348-1214-8 ; 978-3-8348-9651-3},
  pages     = {XII, 410 S.},
  year      = {2010},
  language  = {de}
}
@book{Wollert2010,
  author    = {Wollert, J{\"o}rg},
  title     = {Wireless Technologies : 12. Kongress, 22. - 23. September 2010, Bochum ; von der Technologie zur Anwendung / J{\"o}rg F. Wollert (Hrsg.) (Fortschritt-Berichte VDI : Reihe 10, Informatik, Kommunikation ; 810)},
  publisher = {VDI-Verl.},
  address   = {D{\"u}sseldorf},
  isbn      = {978-3-18-381010-9},
  pages     = {XI, 373 S.},
  year      = {2010},
  language  = {de}
}
@inproceedings{LeidingerSchuermannWollertetal.2010,
  author    = {Leidinger, Rafael and Sch{\"u}rmann, Volker and Wollert, J{\"o}rg and Schneider, Christoph},
  title     = {Entwicklungsprojekt BASic - Bluetooth Authentication Service},
  series = {Wireless Technologies : 12. Kongress, 22. - 23. September 2010, Bochum ; von der Technologie zur Anwendung / J{\"o}rg F. Wollert (Hrsg.) (Fortschritt-Berichte VDI : Reihe 10, Informatik, Kommunikation ; 810)},
  booktitle = {Wireless Technologies : 12. Kongress, 22. - 23. September 2010, Bochum ; von der Technologie zur Anwendung / J{\"o}rg F. Wollert (Hrsg.) (Fortschritt-Berichte VDI : Reihe 10, Informatik, Kommunikation ; 810)},
  publisher = {VDI-Verl.},
  address   = {D{\"u}sseldorf},
  isbn      = {978-3-18-381010-9},
  pages     = {296 -- 303},
  year      = {2010},
  language  = {de}
}
@inproceedings{Wollert2010,
  author    = {Wollert, J{\"o}rg},
  title     = {Grundlagen Wireless Technologie},
  series = {Wireless Technologies : 12. Kongress, 22. - 23. September 2010, Bochum ; von der Technologie zur Anwendung / J{\"o}rg F. Wollert (Hrsg.) (Fortschritt-Berichte VDI : Reihe 10, Informatik, Kommunikation ; 810)},
  booktitle = {Wireless Technologies : 12. Kongress, 22. - 23. September 2010, Bochum ; von der Technologie zur Anwendung / J{\"o}rg F. Wollert (Hrsg.) (Fortschritt-Berichte VDI : Reihe 10, Informatik, Kommunikation ; 810)},
  publisher = {VDI-Verl.},
  address   = {D{\"u}sseldorf},
  pages     = {322 -- 330},
  year      = {2010},
  language  = {de}
}
@inproceedings{HerzwurmKramsPietsch2010,
  author    = {Herzwurm, Georg and Krams, Benedikt and Pietsch, Wolfram},
  title     = {Preisfindung von IT-Produkten durch retrograde Kalkulation},
  series = {Multikonferenz Wirtschaftsinformatik : MKWI 2010, G{\"o}ttingen, 23.-25.2.2010},
  booktitle = {Multikonferenz Wirtschaftsinformatik : MKWI 2010, G{\"o}ttingen, 23.-25.2.2010},
  edition   = {Online-Ausg.},
  organization    = {Multikonferenz Wirtschaftsinformatik <2010, G{\"o}ttingen>},
  pages     = {529 -- 539},
  year      = {2010},
  language  = {de}
}
@incollection{SeiblerSchwenk2010,
  author    = {Seibler, Jost and Schwenk, Frieder},
  title     = {Transgenic RNAi Applications in the Mouse},
  series = {Methods in Enzymology : Guide to Techniques in Mouse Development, Part B: Mouse Molecular Genetics. 2nd Edition},
  booktitle = {Methods in Enzymology : Guide to Techniques in Mouse Development, Part B: Mouse Molecular Genetics. 2nd Edition},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {978-0-12-384880-2},
  pages     = {367 -- 386},
  year      = {2010},
  language  = {en}
}
@article{FellinKingKirschetal.2010,
  author    = {Fellin, Wolfgang and King, Julian and Kirsch, Ansgar and Oberguggenberger, Michael},
  title     = {Uncertainty modelling and sensitivity analysis of tunnel face stability},
  series = {Structural safety},
  volume    = {32},
  journal   = {Structural safety},
  number    = {6},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0167-4730},
  doi       = {10.1016/j.strusafe.2010.06.001},
  pages     = {402 -- 410},
  year      = {2010},
  abstract  = {This paper proposes an approach to the choice and evaluation of engineering models with the aid of a typical application in geotechnics. An important issue in the construction of shallow tunnels, especially in weak ground conditions, is the tunnel face stability. Various theoretical and numerical models for predicting the necessary support pressure have been put forth in the literature. In this paper, we combine laboratory experiments performed at the University of Innsbruck with current methods of uncertainty and sensitivity analysis for assessing adequacy, predictive power and robustness of the models. The major issues are the handling of the twofold uncertainty of test results and of model predictions as well as the decision about what are the influential input parameters.},
  language  = {en}
}
@article{Kirsch2010,
  author    = {Kirsch, Ansgar},
  title     = {Experimental investigation of the face stability of shallow tunnels in sand},
  series = {Acta Geotechnica},
  volume    = {5},
  journal   = {Acta Geotechnica},
  number    = {1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1861-1125},
  doi       = {10.1007/s11440-010-0110-7},
  pages     = {43 -- 62},
  year      = {2010},
  abstract  = {Various models have been proposed for the prediction of the necessary support pressure at the face of a shallow tunnel. To assess their quality, the collapse of a tunnel face was modelled with small-scale model tests at single gravity. The development of the failure mechanism and the support force at the face in dry sand were investigated. The observed displacement patterns show a negligible influence of overburden on the extent and evolution of the failure zone. The latter is significantly influenced, though, by the initial density of the sand: in dense sand a chimney-wedge-type collapse mechanism developed, which propagated towards the soil surface. Initially, loose sand did not show any discrete collapse mechanism. The necessary support force was neither influenced by the overburden nor the initial density. A comparison with quantitative predictions by several theoretical models showed that the measured necessary support pressure is overestimated by most of the models. Those by Vermeer/Ruse and L{\´e}ca/Dormieux showed the best agreement to the measurements.},
  language  = {en}
}
@inproceedings{BungOertelSchlenkhoffetal.2010,
  author    = {Bung, Daniel Bernhard and Oertel, M. and Schlenkhoff, A. and Schlurmann, Torsten},
  title     = {Flash flood awareness and prevention in Germany},
  series = {Early warning for flash floods : international workshop, Praha 2011 : workshop proceedings},
  booktitle = {Early warning for flash floods : international workshop, Praha 2011 : workshop proceedings},
  editor    = {Obrusnik, Ivan},
  organization    = {Czech Hydrometeorological Institute},
  isbn      = {978-80-86690-91-9},
  pages     = {34 -- 40},
  year      = {2010},
  language  = {en}
}
@inproceedings{GellertParkButenweg2010,
  author    = {Gellert, Christoph and Park, Jin and Butenweg, Christoph},
  title     = {Seismic safety verification of masonry structures},
  series = {Proceedings of the Eight International Masonry Conference : held in Dresden from 4th to 7th of July 2010 / [International Masonry Society ; Technische Universit{\"a}t Dresden]. Ed. by: Wolfram J{\"a}ger ... Volume 1. (Masonry / International Masonry Society Special Publication ; 11)},
  booktitle = {Proceedings of the Eight International Masonry Conference : held in Dresden from 4th to 7th of July 2010 / [International Masonry Society ; Technische Universit{\"a}t Dresden]. Ed. by: Wolfram J{\"a}ger ... Volume 1. (Masonry / International Masonry Society Special Publication ; 11)},
  publisher = {ARGE 8IMC Dresden},
  address   = {Radebeul},
  organization    = {International Masonry Conference <8, 2010, Dresden>},
  isbn      = {978-3-00-031381-3},
  pages     = {813 -- 822},
  year      = {2010},
  language  = {en}
}
@inproceedings{BeckerEggertKnackstedt2010,
  author    = {Becker, J{\"o}rg and Eggert, Mathias and Knackstedt, Ralf},
  title     = {Forschungslandkarte Rechtsinformatik und Informationsrecht},
  series = {Proceedings of the Internationales Rechtsinformatik Sysmposium (IRIS), Salzburg, {\"O}sterreich, 2010},
  booktitle = {Proceedings of the Internationales Rechtsinformatik Sysmposium (IRIS), Salzburg, {\"O}sterreich, 2010},
  year      = {2010},
  language  = {de}
}
@inproceedings{BungSchlenkhoff2010,
  author    = {Bung, Daniel Bernhard and Schlenkhoff, Andreas},
  title     = {Self-aerated skimming flow on embankment stepped spillways : the effect of additional micro-roughness on energy dissipation and oxygen transfer},
  series = {Proceedings from first IAHR European congress : May 2010, Edinburgh},
  booktitle = {Proceedings from first IAHR European congress : May 2010, Edinburgh},
  publisher = {Heriot-Watt University, School of the Built Environment},
  address   = {Edinburgh},
  organization    = {International Association for Hydraulic Engineering and Research},
  isbn      = {9780956595102},
  pages     = {Artikelkennnummer HSIIId},
  year      = {2010},
  language  = {en}
}
@article{KozhalakovaZhubanovaMansurovetal.2010,
  author    = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell},
  series = {Science of Central Asia (2010)},
  journal   = {Science of Central Asia (2010)},
  pages     = {50 -- 54},
  year      = {2010},
  language  = {en}
}
@article{AlexopoulosHoffschmidt2010,
  author    = {Alexopoulos, Spiros and Hoffschmidt, Bernhard},
  title     = {Solar tower power plant in Germany and future perspectives of the development of the technology in Greece and Cyprus},
  series = {Renewable Energy . 35 (2010), H. 7},
  journal   = {Renewable Energy . 35 (2010), H. 7},
  isbn      = {0960-1481},
  pages     = {1352 -- 1356},
  year      = {2010},
  language  = {en}
}
@incollection{MeskourisHoltschoppenButenwegetal.2010,
  author    = {Meskouris, Konstantin and Holtschoppen, Britta and Butenweg, Christoph and Park, Jin},
  title     = {Seismische Auslegung von Silo- und Tankbauwerken},
  series = {Festschrift zum 60. Geburtstag von Univ.-Prof. Dr.-Ing. Ingbert Mangerig. (Berichte aus dem konstruktiven Ingenieurbau ; 2010,6)},
  booktitle = {Festschrift zum 60. Geburtstag von Univ.-Prof. Dr.-Ing. Ingbert Mangerig. (Berichte aus dem konstruktiven Ingenieurbau ; 2010,6)},
  publisher = {Univ. der Bundeswehr},
  address   = {Neubiberg},
  pages     = {215 -- 224},
  year      = {2010},
  language  = {de}
}
@book{HoffschmidtLanFrickeetal.2010,
  author    = {Hoffschmidt, Bernhard and Lan, Marco and Fricke, Barbara and Anthrakidis, Anette and Peter, Stefan},
  title     = {Struktur und Dynamik einer Stromversorgung mit einem hohen Anteil erneuerbarer Energieerzeuger. Kurzbezeichnung: Energiestudie. Schlussbericht},
  publisher = {Solar-Institut, FH Aachen},
  address   = {J{\"u}lich},
  pages     = {134 S. Ill., graph. Darst.},
  year      = {2010},
  language  = {de}
}
@inproceedings{BaumannTeixeiraBouraGoettscheetal.2010,
  author    = {Baumann, T. and Teixeira Boura, Cristiano Jos{\´e} and G{\"o}ttsche, Joachim and Hoffschmidt, Bernhard and O'Connell, B. and Schmitz, S. and Zunft, S.},
  title     = {Air/Sand heat exchanger design and materials for solar thermal power plant applications},
  series = {SolarPACES 2010 : the CSP Conference: electricity, fuels and clean water from concentrated solar energy ; 21 to 24 September 2010, Perpignan, France},
  booktitle = {SolarPACES 2010 : the CSP Conference: electricity, fuels and clean water from concentrated solar energy ; 21 to 24 September 2010, Perpignan, France},
  publisher = {Soc. OSC},
  address   = {Saint Maur},
  pages     = {146 -- 147},
  year      = {2010},
  language  = {en}
}
@article{RensVarzinczakMeyeretal.2010,
  author    = {Rens, Gavin and Varzinczak, Ivan and Meyer, Thomas and Ferrein, Alexander},
  title     = {A Logic for Reasoning about Actions and Explicit Observations},
  series = {AI 2010: Advances in Artificial Intelligence 23rd Australasian Joint Conference, Adelaide, Australia, December 7-10, 2010. Proceedings},
  journal   = {AI 2010: Advances in Artificial Intelligence 23rd Australasian Joint Conference, Adelaide, Australia, December 7-10, 2010. Proceedings},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-642-17431-5},
  pages     = {395 -- 404},
  year      = {2010},
  language  = {en}
}
@inproceedings{DammRitzStrauch2010,
  author    = {Damm, Sebastian and Ritz, Thomas and Strauch, Jakob},
  title     = {Benutzerzentrierte Anforderungsanalyse f{\"u}r die Produktlinien-Entwicklung mobiler Unternehmenssoftware},
  series = {EMISA 2010 : Einflussfaktoren auf die Entwicklung flexibler, integrierter Informationssysteme ; Beitr{\"a}ge des Workshops der GI-Fachgruppe Entwicklungsmethoden f{\"u}r Informationssysteme und deren Anwendung (EMISA), 07. - 08.10.2010 in Karlsruhe, Germany. - (GI-Edition : Proceedings ; 172)},
  booktitle = {EMISA 2010 : Einflussfaktoren auf die Entwicklung flexibler, integrierter Informationssysteme ; Beitr{\"a}ge des Workshops der GI-Fachgruppe Entwicklungsmethoden f{\"u}r Informationssysteme und deren Anwendung (EMISA), 07. - 08.10.2010 in Karlsruhe, Germany. - (GI-Edition : Proceedings ; 172)},
  editor    = {Klink, Stefan},
  publisher = {Ges. f{\"u}r Informatik},
  address   = {Bonn},
  isbn      = {978-3-88579-266-6},
  pages     = {117 -- 130},
  year      = {2010},
  language  = {de}
}
@article{FerreinNiemuellerSteinbauer2010,
  author    = {Ferrein, Alexander and Niem{\"u}ller, Tim and Steinbauer, Gerald},
  title     = {Team Zadeat 2010 : application for participation},
  pages     = {5 Seiten},
  year      = {2010},
  language  = {en}
}
@article{SiekerNeunerDimitrovaetal.2010,
  author    = {Sieker, Tim and Neuner, Andreas and Dimitrova, Darina and Tippk{\"o}tter, Nils and Bart, Hans-J{\"o}rg and Heinzle, Elmar and Ulber, Roland},
  title     = {Grassilage als Rohstoff f{\"u}r die chemische Industrie},
  series = {Chemie Ingenieur Technik},
  volume    = {82},
  journal   = {Chemie Ingenieur Technik},
  number    = {8, Special Issue: Industrielle Nutzung nachwachsender Rohstoffe},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1522-2640},
  doi       = {10.1002/cite.201000088},
  pages     = {1153 -- 1159},
  year      = {2010},
  abstract  = {Grassilage stellt einen nachwachsenden Rohstoff mit großem Potenzial dar. Neben Cellulose und Hemicellulose enth{\"a}lt sie auch organische S{\"a}uren, insbesondere Milchs{\"a}ure. In einem Bioraffinerie-Projekt wird die Milchs{\"a}ure aus der Silage isoliert und mit gentechnisch optimierten St{\"a}mmen zu L-Lysin weiterverarbeitet. Die Lignocellulose wird hydrolysiert und zu Ethanol fermentiert. Ein besonderes Augenmerk liegt auf der Integration der unterschiedlichen Prozesse sowie der einzelnen Prozessschritte zu einem Gesamtprozess, der s{\"a}mtliche Inhaltsstoffe der Silage verwertet.},
  language  = {de}
}
@inproceedings{BuckWurmhoeringerLehleetal.2010,
  author    = {Buck, R. and Wurmh{\"o}ringer, K. and Lehle, R. and Pfahl, A. and G{\"o}ttsche, Joachim and Meyr, T.},
  title     = {Development of a 30m2 heliostat with hydraulic drive},
  series = {SolarPACES 2010 : the CSP Conference: electricity, fuels and clean water from concentrated solar energy ; 21 to 24 September 2010, Perpignan, France},
  booktitle = {SolarPACES 2010 : the CSP Conference: electricity, fuels and clean water from concentrated solar energy ; 21 to 24 September 2010, Perpignan, France},
  publisher = {Soc. OSC},
  address   = {Saint Maur},
  pages     = {74 -- 75},
  year      = {2010},
  language  = {en}
}
@misc{ThielTippkoetterSucketal.2010,
  author    = {Thiel, A. and Tippk{\"o}tter, Nils and Suck, K. and Sohling, U. and Ruf, F. and Ulber, Roland},
  title     = {Simulation und Experiment bei der Aufarbeitung von Polyphenolen durch neue Silicatmaterialien},
  series = {Chemie Ingenieur Technik},
  volume    = {82},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201050104},
  pages     = {1589},
  year      = {2010},
  abstract  = {Nachwachsende Rohstoffe stellen eine reichhaltige Quelle f{\"u}r die Gewinnung von wirtschaftlich interessanten Biomolek{\"u}len dar. Die Gruppe der Polyphenole ist dabei f{\"u}r mehrere Industriezweige bedeutend. Ihre antioxidativen Eigenschaften sind z. B. f{\"u}r die Pharmaindustrie interessant. Im derzeit bearbeiteten Projekt sollen Polyphenole aus Pflanzenbestandteilen isoliert und aufgereinigt werden, um sie dann als Komponenten f{\"u}r eine Vernetzung von Polymeren auf der Basis von Fetts{\"a}uren einzusetzen. Bisher sind im Wesentlichen Prozesse zur Entfernung von Polyphenolen aus Getr{\"a}nken wie Bier und Wein bekannt. Eine Wiedergewinnung der Polyphenole war in diesen Anwendungen bisher nicht relevant. Die Gewinnung bzw. Abtrennung der Polyphenole erfolgt u. a. durch kommerziell erh{\"a}ltliche Adsorbentien wie PVPP, Adsorberharze XAD16 (Rh{\"o}m \& Haas) oder SP70 (Sepabeads), deren Partikelgr{\"o}ßen im Bereichvon 0,1 ± 0,8 mm und spezifischen Oberfl{\"a}chen von 700 ± 900 m 2 /g liegen. Als Alternative zu diesen Adsorbern sollen neue Materialien auf Basis von anorganischen Trennmedien, wie z. B. nat{\"u}rlichen Tonmineralien, f{\"u}r die Polyphenolabtrennung verwendet werden. Derzeit wird durch Abgleich von Experiment und Simulation ein Materialscreening durchgef{\"u}hrt. Durch den Einsatz molekulardynamischer Bindungssimulationen wird die Adsorbersuche beschleunigt und Vorhersagen zu Modifikationen bei der Herstellung der neuen Adsorbentien erm{\"o}glicht.},
  language  = {de}
}
@article{KurzLinderTrzewiketal.2010,
  author    = {Kurz, R. and Linder, Peter and Trzewik, J{\"u}rgen and R{\"u}ffer, M. and Artmann, Gerhard and Digel, Ilya and Rothermel, A. and Robitzki, A. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes},
  series = {Medical and Biological Engineering and Computing},
  volume    = {48},
  journal   = {Medical and Biological Engineering and Computing},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1741-0444},
  doi       = {10.1007/s11517-009-0552-y},
  pages     = {59 -- 65},
  year      = {2010},
  abstract  = {The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.},
  language  = {en}
}
@inproceedings{PothMonzonTippkoetteretal.2010,
  author    = {Poth, Sebastian and Monzon, Magaly and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Lignocellulosic biorefinery : process integration of hydrolysis and fermentation},
  series = {Proceedings / 11th European Workshop on Lignocellulosics and Pulp : August 16 - 19, 2010, Hamburg, Germany},
  booktitle = {Proceedings / 11th European Workshop on Lignocellulosics and Pulp : August 16 - 19, 2010, Hamburg, Germany},
  publisher = {vTi},
  address   = {Hamburg},
  pages     = {65 -- 68},
  year      = {2010},
  language  = {en}
}
@article{TippkoetterRoikaewUlberetal.2010,
  author    = {Tippk{\"o}tter, Nils and Roikaew, Wipa and Ulber, Roland and Hoffmann, Alexander and Denzler, Hans-J{\"o}rg and Buchholz, Heinrich},
  title     = {Paracoccus denitrificans for the effluent recycling during continuous denitrification of liquid food},
  series = {Biotechnology Progress},
  volume    = {26},
  journal   = {Biotechnology Progress},
  number    = {3},
  publisher = {Wiley},
  address   = {Hoboken, NJ},
  issn      = {8756-7938},
  doi       = {10.1002/btpr.384},
  pages     = {756 -- 762},
  year      = {2010},
  abstract  = {Nitrate is an undesirable component of several foods. A typical case of contamination with high nitrate contents is whey concentrate, containing nitrate in concentrations up to 25 l. The microbiological removal of nitrate by Paracoccus denitrificans under formation of harmless nitrogen in combination with a cell retention reactor is described here. Focus lies on the resource-conserving design of a microbal denitrification process. Two methods are compared. The application of polyvinyl alcohol-immobilized cells, which can be applied several times in whey feed, is compared with the implementation of a two step denitrification system. First, the whey concentrate's nitrate is removed by ion exchange and subsequently the eluent regenerated by microorganisms under their retention by crossflow filtration. Nitrite and nitrate concentrations were determined by reflectometric color measurement with a commercially available Reflectoquant® device. Correction factors for these media had to be determined. During the pilot development, bioreactors from 4 to 250 mg·L-1 and crossflow units with membrane areas from 0.02 to 0.80 m2 were examined. Based on the results of the pilot plants, a scaling for the exemplary process of denitrifying 1,000 tons per day is discussed.},
  language  = {en}
}
@inproceedings{FeldhusenBrezingPuetzetal.2010,
  author    = {Feldhusen, J{\"o}rg and Brezing, Alexander Nikolaus and P{\"u}tz, Claus and W{\"a}hlisch, Georg},
  title     = {Multi-system CAD-teaching in large classes},
  series = {When design education and design research meet : proceedings of the 12th International Conference on Engineering and Product Design Education, Norwegian University of Science and Technology (NTNU) Trondheim, Norway, 2nd - 3rd September 2010 ; [E\&PDE]},
  booktitle = {When design education and design research meet : proceedings of the 12th International Conference on Engineering and Product Design Education, Norwegian University of Science and Technology (NTNU) Trondheim, Norway, 2nd - 3rd September 2010 ; [E\&PDE]},
  publisher = {Design Society},
  address   = {Glasgow},
  organization    = {International Conference on Engineering and Product Design Education <12, 2010, Trondheim>},
  isbn      = {978-1-904670-19-3},
  pages     = {204 -- 209},
  year      = {2010},
  language  = {en}
}
@article{vonKnobelsdorfBrenkenhoffFrauenrathProthmannetal.2010,
  author    = {von Knobelsdorf-Brenkenhoff, Florian and Frauenrath, Tobias and Prothmann, Marcel and Dieringer, Matthias A. and Hezel, Fabian and Renz, Wolfgang and Kretschel, Kerstin and Niendorf, Thoralf and Schulz-Menger, Jeanette},
  title     = {Cardiac chamber quantification using magnetic resonance imaging at 7 Tesla—a pilot study},
  volume    = {20},
  publisher = {Springer},
  address   = {Berlin, Heidelberg},
  issn      = {0938-7994},
  doi       = {10.1007/s00330-010-1888-2},
  pages     = {2844 -- 2852},
  year      = {2010},
  abstract  = {Objectives Interest in cardiovascular magnetic resonance (CMR) at 7 T is motivated by the expected increase in spatial and temporal resolution, but the method is technically challenging. We examined the feasibility of cardiac chamber quantification at 7 T. Methods A stack of short axes covering the left ventricle was obtained in nine healthy male volunteers. At 1.5 T, steady-state free precession (SSFP) and fast gradient echo (FGRE) cine imaging with 7 mm slice thickness (STH) were used. At 7 T, FGRE with 7 mm and 4 mm STH were applied. End-diastolic volume, end-systolic volume, ejection fraction and mass were calculated. Results All 7 T examinations provided excellent blood/myocardium contrast for all slice directions. No significant difference was found regarding ejection fraction and cardiac volumes between SSFP at 1.5 T and FGRE at 7 T, while volumes obtained from FGRE at 1.5 T were underestimated. Cardiac mass derived from FGRE at 1.5 and 7 T was larger than obtained from SSFP at 1.5 T. Agreement of volumes and mass between SSFP at 1.5 T and FGRE improved for FGRE at 7 T when combined with an STH reduction to 4 mm. Conclusions This pilot study demonstrates that cardiac chamber quantification at 7 T using FGRE is feasible and agrees closely with SSFP at 1.5 T.},
  language  = {en}
}
@article{PhamVuTranetal.2010,
  author    = {Pham, Phu Tinh and Vu, Khoi Duc and Tran, Thanh Ngoc and Staat, Manfred},
  title     = {A primal-dual algorithm for shakedown analysis of elastic-plastic bounded linearly kinematic hardening bodies},
  pages     = {1 -- 7},
  year      = {2010},
  language  = {en}
}
@incollection{MufflerTippkoetterUlber2010,
  author    = {Muffler, Kai and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Chemical feedstocks and fine chemicals from other substrates},
  series = {Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference)},
  booktitle = {Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference)},
  editor    = {Timmis, Kenneth N.},
  publisher = {Springer},
  address   = {Berlin [u.a.]},
  isbn      = {978-3-540-77588-1},
  doi       = {10.1007\%2F978-3-540-77587-4_214},
  pages     = {2891 -- 2902},
  year      = {2010},
  language  = {en}
}
@article{NguyenRaatschenStaat2010,
  author    = {Nguyen, N.-H. and Raatschen, Hans-J{\"u}rgen and Staat, Manfred},
  title     = {A hyperelastic model of biological tissue materials in tubular organs},
  pages     = {1 -- 12},
  year      = {2010},
  language  = {en}
}
@book{Laack2010,
  author    = {Laack, Walter van},
  title     = {Schnittstelle Tod: Aufbruch zu neuem Leben?},
  publisher = {Books on Demand},
  address   = {Norderstedt},
  isbn      = {978-3-936624-10-6},
  pages     = {144 S. : Ill., graph. Darst.},
  year      = {2010},
  language  = {de}
}
@article{BeckerFrauenrathHezeletal.2010,
  author    = {Becker, Meike and Frauenrath, Tobias and Hezel, Fabian and Krombach, Gabriele A. and Kremer, Ute and Koppers, Benedikt and Butenweg, Christoph and Goemmel, Andreas and Utting, Jane F. and Schulz-Menger, Jeanette and Niendorf, Thoralf},
  title     = {Comparison of left ventricular function assessment using phonocardiogram- and electrocardiogram-triggered 2D SSFP CINE MR imaging at 1.5 T and 3.0 T},
  series = {European Radiology},
  volume    = {20},
  journal   = {European Radiology},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1432-1084 (Onlineausgabe)},
  doi       = {10.1007/s00330-009-1676-z},
  pages     = {1344 -- 1355},
  year      = {2010},
  abstract  = {Objective: As high-field cardiac MRI (CMR) becomes more widespread the propensity of ECG to interference from electromagnetic fields (EMF) and to magneto-hydrodynamic (MHD) effects increases and with it the motivation for a CMR triggering alternative. This study explores the suitability of acoustic cardiac triggering (ACT) for left ventricular (LV) function assessment in healthy subjects (n=14). Methods: Quantitative analysis of 2D CINE steady-state free precession (SSFP) images was conducted to compare ACT's performance with vector ECG (VCG). Endocardial border sharpness (EBS) was examined paralleled by quantitative LV function assessment. Results: Unlike VCG, ACT provided signal traces free of interference from EMF or MHD effects. In the case of correct Rwave recognition, VCG-triggered 2D CINE SSFP was immune to cardiac motion effects—even at 3.0 T. However, VCG-triggered 2D SSFP CINE imaging was prone to cardiac motion and EBS degradation if R-wave misregistration occurred. ACT-triggered acquisitions yielded LV parameters (end-diastolic volume (EDV), endsystolic volume (ESV), stroke volume (SV), ejection fraction (EF) and left ventricular mass (LVM)) comparable with those derived fromVCG-triggered acquisitions (1.5 T: ESVVCG=(56± 17) ml, EDVVCG=(151±32)ml, LVMVCG=(97±27) g, SVVCG=(94± 19)ml, EFVCG=(63±5)\% cf. ESVACT= (56±18) ml, EDVACT=(147±36) ml, LVMACT=(102±29) g, SVACT=(91± 22) ml, EFACT=(62±6)\%; 3.0 T: ESVVCG=(55±21) ml, EDVVCG=(151±32) ml, LVMVCG=(101±27) g, SVVCG=(96±15) ml, EFVCG=(65±7)\% cf. ESVACT=(54±20) ml, EDVACT=(146±35) ml, LVMACT= (101±30) g, SVACT=(92±17) ml, EFACT=(64±6)\%). Conclusions: ACT's intrinsic insensitivity to interference from electromagnetic fields renders},
  language  = {en}
}
@inproceedings{GoemmelFrauenrathOttenetal.2010,
  author    = {G{\"o}mmel, Andreas and Frauenrath, Tobias and Otten, Mario and Niendorf, Thoralf and Butenweg, Christoph},
  title     = {In-vivo measurements of vocal fold geometry using Magnetic Resonance Imaging},
  series = {Fortschritte der Akustik - DAGA 2010, 36. Jahrestagung f{\"u}r Akustik},
  booktitle = {Fortschritte der Akustik - DAGA 2010, 36. Jahrestagung f{\"u}r Akustik},
  editor    = {M{\"o}ser, Michael and Schulte-Fortkamp, Brgitte and Ochmann, Martin},
  publisher = {Deutsche Gesellschaft f{\"u}r Akustik},
  address   = {Berlin},
  isbn      = {978-3-9808659-8-2},
  year      = {2010},
  language  = {de}
}
@article{FrauenrathHezelRenzetal.2010,
  author    = {Frauenrath, Tobias and Hezel, Fabian and Renz, Wolfgang and de Geyer d'Orth, Thibaut and Dieringer, Matthias and von Knobelsdorf-Brenkenhoff, Florian and Prothmann, Marcel and Schulz-Menger, Jeanette and Niendorf, Thoralf},
  title     = {Acoustic cardiac triggering: a practical solution for synchronization and gating of cardiovascular magnetic resonance at 7 Tesla},
  series = {Journal of Cardiovascular Magnetic Resonance},
  volume    = {12},
  journal   = {Journal of Cardiovascular Magnetic Resonance},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1532-429X},
  doi       = {10.1186/1532-429X-12-67},
  year      = {2010},
  abstract  = {Background To demonstrate the applicability of acoustic cardiac triggering (ACT) for imaging of the heart at ultrahigh magnetic fields (7.0 T) by comparing phonocardiogram, conventional vector electrocardiogram (ECG) and traditional pulse oximetry (POX) triggered 2D CINE acquisitions together with (i) a qualitative image quality analysis, (ii) an assessment of the left ventricular function parameter and (iii) an examination of trigger reliability and trigger detection variance derived from the signal waveforms. Results ECG was susceptible to severe distortions at 7.0 T. POX and ACT provided waveforms free of interferences from electromagnetic fields or from magneto-hydrodynamic effects. Frequent R-wave mis-registration occurred in ECG-triggered acquisitions with a failure rate of up to 30\% resulting in cardiac motion induced artifacts. ACT and POX triggering produced images free of cardiac motion artefacts. ECG showed a severe jitter in the R-wave detection. POX also showed a trigger jitter of approximately Δt = 72 ms which is equivalent to two cardiac phases. ACT showed a jitter of approximately Δt = 5 ms only. ECG waveforms revealed a standard deviation for the cardiac trigger offset larger than that observed for ACT or POX waveforms. Image quality assessment showed that ACT substantially improved image quality as compared to ECG (image quality score at end-diastole: ECG = 1.7 ± 0.5, ACT = 2.4 ± 0.5, p = 0.04) while the comparison between ECG vs. POX gated acquisitions showed no significant differences in image quality (image quality score: ECG = 1.7 ± 0.5, POX = 2.0 ± 0.5, p = 0.34). Conclusions The applicability of acoustic triggering for cardiac CINE imaging at 7.0 T was demonstrated. ACT's trigger reliability and fidelity are superior to that of ECG and POX. ACT promises to be beneficial for cardiovascular magnetic resonance at ultra-high field strengths including 7.0 T.},
  language  = {en}
}
@inproceedings{BorggraefeDachwald2010,
  author    = {Borggr{\"a}fe, Andreas and Dachwald, Bernd},
  title     = {Mission performance evaluation for solar sails using a refined SRP force model with variable optical coefficients},
  series = {2nd International Symposium on Solar Sailing},
  booktitle = {2nd International Symposium on Solar Sailing},
  pages     = {1 -- 6},
  year      = {2010},
  abstract  = {Solar sails provide ignificant advantages over other low-thrust propulsion systems because they produce thrust by the momentum exchange from solar radiation pressure (SRP) and thus do not consume any propellant.The force exerted on a very thin sail foil basically depends on the light incidence angle. Several analytical SRP force models that describe the SRP force acting on the sail have been established since the 1970s. All the widely used models use constant optical force coefficients of the reflecting sail material. In 2006,MENGALI et al. proposed a refined SRP force model that takes into account the dependancy of the force coefficients on the light incident angle,the sail's distance from the sun (and thus the sail emperature) and the surface roughness of the sail material [1]. In this paper, the refined SRP force model is compared to the previous ones in order to identify the potential impact of the new model on the predicted capabilities of solar sails in performing low-cost interplanetary space missions. All force models have been implemented within InTrance, a global low-thrust trajectory optimization software utilizing evolutionary neurocontrol [2]. Two interplanetary rendezvous missions, to Mercury and the near-Earth asteroid 1996FG3, are investigated. Two solar sail performances in terms of characteristic acceleration are examined for both scenarios, 0.2 mm/s2 and 0.5 mm/s2, termed "low" and "medium" sail performance. In case of the refined SRP model, three different values of surface roughness are chosen, h = 0 nm, 10 nm and 25 nm. The results show that the refined SRP force model yields shorter transfer times than the standard model.},
  language  = {en}
}
@inproceedings{KapoorBollerGiljohannetal.2010,
  author    = {Kapoor, Hrshi and Boller, Christian and Giljohann, Sebastian and Braun, Carsten},
  title     = {Strategies for structural health monitoring implementation potential assessment in aircraft operational life extension considerations},
  series = {2nd International Symposium on NDT in Aerospace : November 22-24, 2010 Hamburg, Germany},
  booktitle = {2nd International Symposium on NDT in Aerospace : November 22-24, 2010 Hamburg, Germany},
  publisher = {Dt. Gesellschaft f{\"u}r Zerst{\"o}rungsfreie Pr{\"u}fung},
  address   = {Berlin},
  organization    = {Deutsche Gesellschaft f{\"u}r Zerst{\"o}rungsfreie Pr{\"u}fung},
  isbn      = {978-3-940283-28-3},
  pages     = {9},
  year      = {2010},
  language  = {en}
}
@book{Tippkoetter2010,
  author    = {Tippk{\"o}tter, Nils},
  title     = {Reaktionssysteme zur Aufarbeitung und Umsetzung nachwachsender Rohstoffe : Einsatz chromatographischer Verfahren sowie Membran- und Festbettreaktoren zur Verarbeitung von Molke, St{\"a}rke und Cellulose},
  publisher = {Logos-Verlag},
  address   = {Berlin},
  isbn      = {978-3-8325-2717-4},
  pages     = {III, 269 Seiten},
  year      = {2010},
  language  = {de}
}
@inproceedings{FrauenrathGoemmelButenwegetal.2010,
  author    = {Frauenrath, Tobias and G{\"o}mmel, Andreas and Butenweg, Christoph and Otten, Mario and Niendorf, Thoralf},
  title     = {3D mapping of vocal fold geometry during articulatory maneuvers using ultrashort echo time imaging at 3.0 T},
  series = {ISMRM-ESMRMB joint annual meeting 2010, Band 4},
  booktitle = {ISMRM-ESMRMB joint annual meeting 2010, Band 4},
  publisher = {Curran},
  address   = {Red Hook, NY},
  organization    = {International Society of Magnetic Resonance in Medicine},
  isbn      = {978-1-617-82008-3},
  pages     = {3087},
  year      = {2010},
  language  = {en}
}
@article{SiqueiraMakiPaulovichetal.2010,
  author    = {Siqueira, Jose R. and Maki, Rafael M. and Paulovich, Fernando V. and Werner, Frederik and Poghossian, Arshak and Oliveira, Maria C. F. de and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef},
  title     = {Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor},
  series = {Analytical Chemistry (2010)},
  journal   = {Analytical Chemistry (2010)},
  isbn      = {0003-2700},
  pages     = {61 -- 65},
  year      = {2010},
  language  = {en}
}
@article{ArampatzisPeperBierbaumetal.2010,
  author    = {Arampatzis, Adamantios and Peper, Andreas and Bierbaum, Stefanie and Albracht, Kirsten},
  title     = {Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain},
  series = {Journal of Biomechanics},
  volume    = {43},
  journal   = {Journal of Biomechanics},
  number    = {16},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0021-9290},
  doi       = {10.1016/j.jbiomech.2010.08.014},
  pages     = {3073 -- 3079},
  year      = {2010},
  abstract  = {The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47\%), and the other leg at high tendon strain magnitude (4.72±1.08\%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon-aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon-aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.},
  language  = {en}
}
@article{AggeloussisGiannakouAlbrachtetal.2010,
  author    = {Aggeloussis, Nickos and Giannakou, Erasmia and Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Reproducibility of fascicle length and pennation angle of gastrocnemius medialis in human gait in vivo},
  series = {Gait and Posture},
  volume    = {31},
  journal   = {Gait and Posture},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0966-6362},
  doi       = {10.1016/j.gaitpost.2009.08.249},
  pages     = {73 -- 77},
  year      = {2010},
  abstract  = {The purpose of the current study was to examine the reproducibility of fascicle length and pennation angle of gastrocnemius medialis while human walking. To the best of our knowledge, this is the first study of the reproducibility of fascicle length and pennation angle of gastrocnemius medialis in vivo during human gait. Twelve males performed 10 gait trials on a treadmill, in 2 separate days. B-mode ultrasonography, with the ultrasound probe firmly adjusted in the transverse and frontal planes using a special cast, was used to measure the fascicle length and the pennation angle of the gastrocnemius medialis (GM). A Vicon 624 system with three cameras operating at 120 Hz was also used to record the ankle and knee joint angles. The results showed that measurements of fascicle length and pennation angle showed high reproducibility during the gait cycle, both within the same day and between different days. Moreover, the root mean square differences between the repeated waveforms of both variables were very small, compared with their ranges (fascicle length: RMS = ∼3 mm, range: 38-63 mm; pennation angle: RMS = ∼1.5°, range: 22-32°). However, their reproducibility was lower compared to the joint angles. It was found that representative data have to be derived by a wide number of gait trials (fascicle length ∼six trials, pennation angle more than 10 trials), to assure the reliability of the fascicle length and pennation angle in human gait.},
  language  = {en}
}
@article{FleischhakerEversDey2010,
  author    = {Fleischhaker, Robert and Evers, J{\"o}rg and Dey, Tarak N.},
  title     = {Phase modulation induced by cooperative effects in electromagnetically induced transparency},
  series = {Physical Review A - Atomic, molecular, and optical physics},
  volume    = {82},
  journal   = {Physical Review A - Atomic, molecular, and optical physics},
  number    = {1},
  publisher = {AIP Publishing},
  address   = {Melville, NY},
  issn      = {1050-2947},
  doi       = {10.1103/PhysRevA.82.013815},
  pages     = {013815},
  year      = {2010},
  abstract  = {We analyze the influence of dipole-dipole interactions in an electromagnetically induced transparency set up for a density at the onset of cooperative effects. To this end, we include mean-field models for the influence of local-field corrections and radiation trapping into our calculation. We show both analytically and numerically that the polarization contribution to the local field strongly modulates the phase of a weak pulse. We give an intuitive explanation for this local-field-induced phase modulation and demonstrate that it distinctively differs from the nonlinear self-phase-modulation that a strong pulse experiences in a Kerr medium.},
  language  = {en}
}
@incollection{EversFleischhakerPalffyetal.2010,
  author    = {Evers, J{\"o}rg and Fleischhaker, Robert and P{\´a}lffy, A. and Keitel, C.},
  title     = {Light propagation : From atomic to nuclear quantum optics},
  series = {Modern optics and photonics: atoms and structured media},
  booktitle = {Modern optics and photonics: atoms and structured media},
  publisher = {World Scientific Publishing Co.},
  isbn      = {978-981431327-8},
  doi       = {10.1142/9789814313278_0001},
  pages     = {3 -- 15},
  year      = {2010},
  language  = {en}
}
@inproceedings{PaslighFunkeRoethetal.2010,
  author    = {Pasligh, N. and Funke, D. and R{\"o}th, Thilo and Krack, R.},
  title     = {Leichtbau Quertrager als Stahlblech-Aluminiumdruckguss-Hybrid - Von der numerischen Berechnung bis zum realen Prototypen},
  series = {VDI BERICHTE},
  booktitle = {VDI BERICHTE},
  publisher = {VDI Verlag},
  address   = {D{\"u}sseldorf},
  isbn      = {978-3-18-092107-5},
  pages     = {688 Seiten},
  year      = {2010},
  language  = {de}
}
@book{Hoehne2010,
  author    = {H{\"o}hne, Tim},
  title     = {Einfl{\"u}sse von Make or Buy-Entscheidungen auf die Termintreue},
  publisher = {Apprimus Verl.},
  address   = {Aachen},
  isbn      = {978-3-940565-64-8},
  pages     = {XIII, 252 S. : Ill., graph. Darst},
  year      = {2010},
  language  = {de}
}
@article{RossPlummerRodeetal.2010,
  author    = {Ross, Jillian and Plummer, Simon M. and Rode, Anja and Scheer, Nico and Bower, Conrad C. and Vogel, Ortwin and Henderson, Colin J. and Wolf, C. Roland and Elcombe, Clifford R.},
  title     = {Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo},
  series = {Toxicological Sciences},
  volume    = {116},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1096-0929},
  doi       = {10.1093/toxsci/kfq118},
  pages     = {452 -- 466},
  year      = {2010},
  abstract  = {Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel "humanized" and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained.},
  language  = {en}
}
@article{ScheerRossKapelyukhetal.2010,
  author    = {Scheer, Nico and Ross, Jillian and Kapelyukh, Yury and Rode, Anja and Wolf, C. Roland},
  title     = {In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice},
  series = {Drug Metabolism and Disposition},
  volume    = {38},
  journal   = {Drug Metabolism and Disposition},
  number    = {7},
  publisher = {ASPET},
  address   = {Bethesda},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.109.031872},
  pages     = {1046 -- 1053},
  year      = {2010},
  abstract  = {Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.},
  language  = {en}
}