@inproceedings{WiesenEngemannLimpertetal.2018,
  author    = {Wiesen, Patrick and Engemann, Heiko and Limpert, Nicolas and Kallweit, Stephan},
  title     = {Learning by Doing - Mobile Robotics in the FH Aachen ROS Summer School},
  series = {European Robotics Forum 2018, TRROS18 Workshop},
  booktitle = {European Robotics Forum 2018, TRROS18 Workshop},
  pages     = {47 -- 58},
  year      = {2018},
  language  = {en}
}
@article{Thomas2018,
  author    = {Thomas, Axel},
  title     = {Zielerreichungen der Technologie- und Gr{\"u}nderzentren aus Sicht der kommunalen Finanzwirtschaft - dargestellt am Beispiel der Aachener Region},
  series = {Der Gemeindehaushalt},
  volume    = {119},
  journal   = {Der Gemeindehaushalt},
  number    = {7},
  publisher = {Kohlhammer},
  address   = {Stuttgart},
  issn      = {0340-3645},
  pages     = {149 -- 155},
  year      = {2018},
  language  = {de}
}
@article{Thomas2018,
  author    = {Thomas, Axel},
  title     = {Technologiezentren in der Aachener Region - Retrospektiven und Perspektiven},
  series = {VM Verwaltung und Management},
  volume    = {24},
  journal   = {VM Verwaltung und Management},
  number    = {3},
  publisher = {Nomos},
  address   = {Baden-Baden},
  issn      = {0947-9856},
  doi       = {10.5771/0947-9856-2018-3-147},
  pages     = {147 -- 156},
  year      = {2018},
  language  = {de}
}
@article{SchmidtEnningPfaff2018,
  author    = {Schmidt, Bernd and Enning, Manfred and Pfaff, Raphael},
  title     = {G{\"u}terwagen 4.0 - Der G{\"u}terwagen f{\"u}r das Internet der Dinge Teil 3: Einf{\"u}hrungsszenarien f{\"u}r aktive, kommunikative G{\"u}terwagen},
  series = {ETR - Eisenbahntechnische Rundschau},
  volume    = {67},
  journal   = {ETR - Eisenbahntechnische Rundschau},
  number    = {5},
  publisher = {DVV Media Group},
  address   = {Hamburg},
  issn      = {0013-2845},
  pages     = {60 -- 64},
  year      = {2018},
  abstract  = {Wenn durch innovative, automatisierte G{\"u}terwagen betriebswirtschaftliche Vorteile nutzbar gemacht werden sollen, muss die Migration auf das neue System in sinnvollen Teilschritten unter Ber{\"u}cksichtigung der organisationellen und betrieblichen Vereinbarkeit vorgenommen werden. Eine stufenweise Migration mit Nachr{\"u}stbarkeit und Kompatibilit{\"a}t kann die optimale Ausstattungsvariante f{\"u}r die unterschiedlichen Betriebsszenarien sowie eine Steigerung der Wirtschaftlichkeit des Gesamtsystems bieten.},
  language  = {de}
}
@inproceedings{PfaffMelcherFranzen2018,
  author    = {Pfaff, Raphael and Melcher, Karin and Franzen, Julian},
  title     = {Rare event simulation to optimise maintenance intervals of safety critical redundant subsystems},
  series = {Proceedings of the European Conference of the PHM Society},
  volume    = {4},
  booktitle = {Proceedings of the European Conference of the PHM Society},
  number    = {1},
  pages     = {1 -- 6},
  year      = {2018},
  language  = {en}
}
@inproceedings{Pfaff2018,
  author    = {Pfaff, Raphael},
  title     = {Railway Challenge 2018 - Ein Wettbewerb f{\"u}r Parkbahn-Lokomotiven},
  series = {Deine Bahn},
  booktitle = {Deine Bahn},
  issn      = {0948-7263},
  pages     = {22 -- 24},
  year      = {2018},
  language  = {de}
}
@article{FranzenPindersPfaffetal.2018,
  author    = {Franzen, Julius and Pinders, Erik and Pfaff, Raphael and Enning, Manfred},
  title     = {RailCrowd's virtual fleets: Make most of your asset data},
  series = {Deine Bahn},
  journal   = {Deine Bahn},
  number    = {9},
  publisher = {Bahn-Fachverlag},
  address   = {Berlin},
  issn      = {0948-7263},
  pages     = {11 -- 13},
  year      = {2018},
  abstract  = {For smaller railway operators or those with a diverse fleet, it can be difficult to collect sufficient data to improve maintenance programs. At the same time, new rules such as entity in charge of maintenance - ECM - regulations impose an additional workload by requiring a dedicated maintenance management system and specific reports. The RailCrowd platform sets out to facilitate compliance with ECM and similar regulations while at the same time pooling anonymised fleet data across operators to form virtual fleets, providing greater data insights.},
  language  = {en}
}
@inproceedings{GaoBabilonPfaffetal.2018,
  author    = {Gao, H. and Babilon, Katharina and Pfaff, Raphael and Gan, F. and Reich, A.},
  title     = {Model of wheel-rail contact for sanding and adhesion enhancement},
  series = {Proceedings of the 11th International Conference on Contact Mechanics and Wear of Rail/wheel Systems, CM 2018},
  booktitle = {Proceedings of the 11th International Conference on Contact Mechanics and Wear of Rail/wheel Systems, CM 2018},
  isbn      = {978-946186963-0},
  pages     = {314 -- 321},
  year      = {2018},
  language  = {en}
}
@inproceedings{BueckingPfaffDirksmeier2018,
  author    = {B{\"u}cking, Henrik and Pfaff, Raphael and Dirksmeier, Roger},
  title     = {Sensor positioning and thermal model for condition monitoring of pressure gas reservoirs in vehicles},
  series = {Proceedings of the Fourth European Conference of the Prognostics and Health Management Society, Utrecht, Netherlands, 2018},
  booktitle = {Proceedings of the Fourth European Conference of the Prognostics and Health Management Society, Utrecht, Netherlands, 2018},
  pages     = {5 Seiten},
  year      = {2018},
  language  = {en}
}
@article{BabilonWilbringTappertetal.2018,
  author    = {Babilon, Katharina and Wilbring, Daniela and Tappert, Tim and Pfaff, Raphael and Enning, Manfred},
  title     = {Schienenfahrzeugtechnik hands on - FH Aachen IMechE Railway Challenge},
  series = {Ingenieurspiegel},
  journal   = {Ingenieurspiegel},
  number    = {2},
  publisher = {Public Verlag},
  address   = {Bingen},
  issn      = {1868-5919},
  pages     = {20 -- 22},
  year      = {2018},
  language  = {de}
}
@article{KlockeRichertSube2018,
  author    = {Klocke, Martina and Richert, Vera and Sube, Maike},
  title     = {Vier Jahre „Guter Studienstart im Ingenieurbereich": Entwicklung und Perspektiven des „Nullten Semesters" in Aachen},
  series = {Zeitschrift f{\"u}r Beratung und Studium},
  volume    = {13},
  journal   = {Zeitschrift f{\"u}r Beratung und Studium},
  number    = {1},
  publisher = {Universit{\"a}tsverlag Webler},
  address   = {Bielefeld},
  issn      = {1860-3068},
  pages     = {17 -- 22},
  year      = {2018},
  abstract  = {Bereits 2015 wurde in der Zeitschrift „Qualit{\"a}t in der Wissenschaft" (QiW) {\"u}ber das Kooperationsprojekt „Guter Studienstart im Ingenieurbereich", das Orientierungssemester von RWTH und FH Aachen, berichtet. In diesem Artikel legen wir den Schwerpunkt auf die Entwicklung des Projekts in den Jahren 2015 bis 2018 und geben eine R{\"u}ckschau sowie einen Ausblick auf die Entwicklungsperspektiven nach dem offiziellen Projektende.},
  language  = {de}
}
@incollection{Klocke2018,
  author    = {Klocke, Martina},
  title     = {Schulter an Schulter - Zusammenarbeit in einem differenzierten Hochschulsystem},
  series = {Lehre und Lehrentwicklung an Fachhochschulen - Festschrift f{\"u}r Prof. Dr. med. W. Huhn},
  booktitle = {Lehre und Lehrentwicklung an Fachhochschulen - Festschrift f{\"u}r Prof. Dr. med. W. Huhn},
  publisher = {Waxmann},
  address   = {M{\"u}nster},
  isbn      = {978-3-8309-3782-1},
  pages     = {75 -- 80},
  year      = {2018},
  language  = {de}
}
@inproceedings{ThurnGebhardt2018,
  author    = {Thurn, Laura and Gebhardt, Andreas},
  title     = {Strategy of Education on Materials for Students},
  series = {Conference Proceedings: „New Perspectives in Science Education"},
  booktitle = {Conference Proceedings: „New Perspectives in Science Education"},
  address   = {Florence, Italy},
  isbn      = {978-88-6292-976-9},
  pages     = {156 -- 161},
  year      = {2018},
  language  = {en}
}
@inproceedings{RendonDieckmannWeidleetal.2018,
  author    = {Rendon, Carlos and Dieckmann, Simon and Weidle, Mathias and Dersch, J{\"u}rgen and Teixeira Boura, Cristiano Jos{\´e} and Polklas, Thomas and Kuschel, Marcus and Herrmann, Ulf},
  title     = {Retrofitting of existing parabolic trough collector power plants with molten salt tower systems},
  series = {AIP Conference Proceedings},
  volume    = {2033},
  booktitle = {AIP Conference Proceedings},
  number    = {1},
  doi       = {10.1063/1.5067030},
  pages     = {030014-1 -- 030014-8},
  year      = {2018},
  language  = {en}
}
@misc{OPUS4-8740,
  title     = {Dimensionen 1-2018: Magazin der FH Aachen University of Applied Sciences - Grenzg{\"a}nge},
  organization    = {FH Aachen, University of Applied Sciences},
  pages     = {62 Seiten},
  year      = {2018},
  abstract  = {Grenzg{\"a}nge: Op j{\"o}ck in Vaals mit Peter Sparla Inhaltsverzeichnis 6 "Mr. Vaals": Ein Spaziergang mit Peter Sparla durch die niederl{\"a}ndische Gemeinde 14 Ein Verein hebt ab: Von der Theorie in die Praxis: Die Flugtechnische Arbeitsgemeinschaft will Studierende f{\"u}rs Fliegen begeistern 18 Vom Flugplatzkind zur Ingenieurin: Sarah Hamacher hat Luft- und Raumfahrt studiert und arbeitet jetzt bei der ADAC-Luftfahrttechnik 20 Mit Sonne im Tank durch das australische Outback: FH-Student Enno D{\"u}lberg berichtet von der World Solar Challenge 24 Es steckt mehr dahinter: Eine Eschweiler Firma entwickelt Elektronik-L{\"o}sungen f{\"u}r Anh{\"a}ngerkupplungen - mit Unterst{\"u}tzung der FH Aachen 27 Von Mekn{\`e}s nach J{\"u}lich: Die Geschichte von Rabab Azizi 28 Das blaue Wunder neu erleben: Aachener Tuchtradition soll wieder in Mode kommen 32 Es werde Licht: Markus van Hauten macht spektakul{\"a}re Landschaftsfotos 36 Maschinenbau von morgen: Dr. Julia Kessler forscht zu additiv gefertigten Leichtbaustrukturen 39 Vier Siebenen und eine Eins: Kopfnuss 40 Auf Tuchf{\"u}hlung mit der Praxis: Das ausbildungsintegrierende Studium ist anspruchsvoll und fordernd. Aber es bietet den Studierenden und Unternehmen auch viel. 44 Eine große B{\"u}hne f{\"u}r die Forschung: FH aachen pr{\"a}sentiert das Spektrum ihrer wissenschaftlichen Arbeit 46 Eine Erfolgsstory: Das Institut f{\"u}r Nano- und Biotechnologien feiert sein 10-j{\"a}hriges Jubil{\"a}um 49 Das Ingenieurstudium fr{\"u}her und heute: Der Verein "Ingenieurfreunde der FH Aachen" blickt auf eine ereignisreiche Zeit zur{\"u}ck 50 Ist es ein Flugzeug? Ist es ein Multikopter: Nein es ist PhoenAix! Das Flugger{\"a}t soll Vorteile von Flugzeug- und Hubschraubertechnik kombinieren 54 G{\"u}terwagen der Zukunft: Im Studiengang Schienfahrzeugtechnik wird an intelligenten und hoch technisierten G{\"u}terwaggons gearbeitet 58 Wenn Gedanken Gestalt annehmen: Prof. Thomas T{\"u}nnemann zum Projekt Neo Forma 60 Vorhang auf f{\"u}r die Wissenschaft: Future-Lab-Gala im Theater Aachen 62 Impressum},
  language  = {de}
}
@misc{OPUS4-8741,
  title     = {Dimensionen 2-2018: Magazin der FH Aachen University of Applied Sciences - Virtuelle Realit{\"a}ten},
  address   = {Aachen},
  organization    = {FH Aachen, University of Applied Sciences},
  pages     = {63 Seiten},
  year      = {2018},
  abstract  = {Virtuelle Realit{\"a}ten Inhaltsverzeichnis 6 Erweiterte Dimensionen: Special zum Thema Virtual Reality 10 "VR und AR werden unsere Welt durchdringen": Ein Interview zum Potenzial von Virtual und Augmented Reality 14 Lernen aus einem anderen Blickwinkel: VR wird in Studium und Lehre zunehmend angewandt 18 Parallele Realit{\"a}ten in der Forschung: Virtual und Augmented Reality in Forschungsprojekten 22 Willkommen in der Welt der M{\"o}glichkeiten: Wie real ist die Illusion der Realit{\"a}t 24 Eine z{\"u}ndende Idee: Institut f{\"u}r Mikrowellen- und Plasmatechnik (IMP) entwickelt neue Plasmaz{\"u}ndkerze f{\"u}r sparsamere Benzinmotoren 28 Der Elefant im Park: "WESTPARK story constructed": Studierende bauen skulpturales M{\"o}bel 30 Herr Bernoulli geht auf Reisen: Das "aero | race lab" bringt Experimente zur Luft- und Raumfahrt an die Schulen 32 Eine Auszeit vom Alltag: Martin Stockberg schafft Kunstwerke im Sand 36 Der Einer im urbanen Mobilit{\"a}tstetris: An der FH Aachen wird urbane Elektromobilit{\"a}t neu gedacht 39 Der Primzahlw{\"u}rfel: Kopfnuss 40 Schwarz Weiß Bunt: Die politische Kunst des FH-Absolventen Ralf Metzenmacher 44 Die Champions League des Schweißens: LaVa-X will das Laserstrahlschweißen im Vakuum etablieren 46 Auf der Suche nach dem goldenen Schnatz: St{\"o}cke statt Besen. Spielfeld statt Arena. In J{\"u}lich spielen Studierende Quidditch. 48 Bei ihm wird Science-Fiction zu Science-Fact: Volker Schmid erz{\"a}hlt von seiner Arbeit beim Deutschen Zentrum f{\"u}r Luft- und Raumfahrt (DLR) 52 Die Ideenschmieden: Junge Menschen aus aller Welt diskutieren bei den Summerschools {\"u}ber Zukunftsthemen 56 Forschung auf h{\"o}chstem Niveau: Dr. Jan Oberl{\"a}nder und Doktorand Dua {\"O}zsoylu stehen f{\"u}r das, was das Institut f{\"u}r Nano- und Biotechnologien auszeichnet 58 Der Dom und ich: Dompublikation und LEGO-Throne zum Jubil{\"a}um 40 Jahre UNESCO-Weltkulturerbe 62 Sag "Ja" zum Studium: Der neue kooperative Bachelorstudiengang "Elektrotechnik mit Orientierungssemester" 63 Impressum},
  language  = {de}
}
@techreport{BerneckerBoyerGathmann2018,
  type      = {Working Paper},
  author    = {Bernecker, Andreas and Boyer, Pierre and Gathmann, Christina},
  title     = {The Role of Electoral Incentives for Policy Innovation: Evidence from the US Welfare Reform},
  series = {CESifo Working Paper},
  journal   = {CESifo Working Paper},
  number    = {No. 6964},
  organization    = {CESifo Group Munich},
  issn      = {ISSN 2364-1428 (electronic version)},
  pages     = {60},
  year      = {2018},
  language  = {en}
}
@article{BerneckerKlierSternetal.2018,
  author    = {Bernecker, Andreas and Klier, Julia and Stern, Sebastian and Thiel, Lea},
  title     = {Sustaining high performance beyond public-sector pilot projects.},
  number    = {September 2018},
  organization    = {McKinsey\&Company},
  year      = {2018},
  language  = {en}
}
@inproceedings{RichterBraunsteinStaeudleetal.2018,
  author    = {Richter, Charlotte and Braunstein, Bjoern and St{\"a}udle, Benjamin and Attias, Julia and Suess, Alexander and Weber, T. and Rittweger, Joern and Green, David A. and Albracht, Kirsten},
  title     = {In vivo fascicle length of the gastrocnemius muscle during walking in simulated martian gravity using two different body weight support devices},
  series = {23rd Annual Congress of the European College of Sport Science, Dublin, Irland},
  booktitle = {23rd Annual Congress of the European College of Sport Science, Dublin, Irland},
  year      = {2018},
  language  = {en}
}
@phdthesis{Keinz2018,
  author    = {Keinz, Jan},
  title     = {Optimization of a Dry Low NOx Micromix Combustor for an Industrial Gas Turbine Using Hydrogen-Rich Syngas Fuel},
  publisher = {Universit{\´e} Libre de Bruxelles - Brussels School of Engineering Aero-Thermo-Mechanics},
  address   = {Br{\"u}ssel},
  year      = {2018},
  language  = {en}
}
@book{FockeSteinbeck2018,
  author    = {Focke, Markus and Steinbeck, J{\"o}rn},
  title     = {Steigerung der Anlagenproduktivit{\"a}t durch OEE-Management : Definitionen, Vorgehen und Methoden - von manuell bis Industrie 4.0},
  publisher = {Springer Fachmedien},
  address   = {Wiesbaden},
  isbn      = {978-3-658-21456-2},
  doi       = {10.1007/978-3-658-21456-2},
  year      = {2018},
  language  = {de}
}
@article{HirschKleebergSchmitz2018,
  author    = {Hirsch, Marko and Kleeberg, Jochen and Schmitz, Philipp},
  title     = {Dynamische Asset-Allocation- Strategien im Niedrigzinsumfeld},
  series = {Absolut|report : neue Perspektiven f{\"u}r institutionelle Investoren},
  journal   = {Absolut|report : neue Perspektiven f{\"u}r institutionelle Investoren},
  number    = {6},
  publisher = {Absolut Research},
  address   = {Hamburg},
  pages     = {52},
  year      = {2018},
  language  = {de}
}
@incollection{SchoeningPoghossian2018,
  author    = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak},
  title     = {Enzyme und Biosensorik},
  series = {Einf{\"u}hrung in die Enzymtechnologie},
  booktitle = {Einf{\"u}hrung in die Enzymtechnologie},
  publisher = {Springer Spektrum},
  address   = {Berlin},
  isbn      = {978-3-662-57619-9},
  doi       = {10.1007/978-3-662-57619-9_18},
  pages     = {323 -- 347},
  year      = {2018},
  abstract  = {Enzymbasierte Biosensoren finden seit mehr als f{\"u}nf Jahrzehnten einen prosperierenden Wachstumsmarkt und werden zunehmend auch in biotechnologischen Prozessen eingesetzt. In diesem Kapitel werden, ausgehend vom Sensorbegriff und typischen Kenngr{\"o}ßen f{\"u}r Biosensoren (Abschn. 18.1), elektrochemische Enzym-Biosensoren vorgestellt und deren typischen Einsatzgebiete diskutiert (Abschn. 18.2). Ein Blick {\"u}ber den „Tellerrand" hinaus zeigt alternative Transduktorprinzipien (Abschn. 18.3) und f{\"u}hrt abschließend in aktuelle Forschungstrends ein (Abschn. 18.4).},
  language  = {de}
}
@article{BergSchleserDelidovichetal.2018,
  author    = {Berg, Alexander-Karl and Schleser, Markus and Delidovich, Artem and Houben, Alexander},
  title     = {Ultraschallunterst{\"u}tzter Schmelzklebstoffauftrag},
  series = {adh{\"a}sion KLEBEN \& DICHTEN},
  volume    = {Volume 62},
  journal   = {adh{\"a}sion KLEBEN \& DICHTEN},
  number    = {Issue 12},
  publisher = {Springer},
  doi       = {10.1007/s35145-018-0089-z},
  pages     = {32 -- 37},
  year      = {2018},
  language  = {de}
}
@article{FingerBraunBil2018,
  author    = {Finger, Felix and Braun, Carsten and Bil, Cees},
  title     = {Impact of electric propulsion technology and mission requirements on the performance of VTOL UAVs},
  series = {CEAS Aeronautical Journal},
  volume    = {10},
  journal   = {CEAS Aeronautical Journal},
  number    = {3},
  publisher = {Springer},
  issn      = {1869-5582 print},
  doi       = {10.1007/s13272-018-0352-x},
  pages     = {843},
  year      = {2018},
  abstract  = {One of the engineering challenges in aviation is the design of transitioning vertical take-off and landing (VTOL) aircraft. Thrust-borne flight implies a higher mass fraction of the propulsion system, as well as much increased energy consumption in the take-off and landing phases. This mass increase is typically higher for aircraft with a separate lift propulsion system than for aircraft that use the cruise propulsion system to support a dedicated lift system. However, for a cost-benefit trade study, it is necessary to quantify the impact the VTOL requirement and propulsion configuration has on aircraft mass and size. For this reason, sizing studies are conducted. This paper explores the impact of considering a supplemental electric propulsion system for achieving hovering flight. Key variables in this study, apart from the lift system configuration, are the rotor disk loading and hover flight time, as well as the electrical systems technology level for both batteries and motors. Payload and endurance are typically used as the measures of merit for unmanned aircraft that carry electro-optical sensors, and therefore the analysis focuses on these particular parameters.},
  language  = {en}
}
@article{EngelHoltmannUlberetal.2018,
  author    = {Engel, Mareike and Holtmann, Dirk and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Increased Biobutanol Production by Mediator-Less Electro-Fermentation},
  series = {Biotechnology Journal},
  journal   = {Biotechnology Journal},
  number    = {Volume 14, Issue 4},
  publisher = {Wiley-VCH},
  issn      = {1860-7314},
  doi       = {10.1002/biot.201800514},
  pages     = {Artikel 1800514},
  year      = {2018},
  abstract  = {A future bio-economy should not only be based on renewable raw materials but also in the raise of carbon yields of existing production routes. Microbial electrochemical technologies are gaining increased attention for this purpose. In this study, the electro-fermentative production of biobutanol with C. acetobutylicum without the use of exogenous mediators is investigated regarding the medium composition and the reactor design. It is shown that the use of an optimized synthetic culture medium allows higher product concentrations, increased biofilm formation, and higher conductivities compared to a synthetic medium supplemented with yeast extract. Moreover, the optimization of the reactor system results in a doubling of the maximum product concentrations for fermentation products. When a working electrode is polarized at -600 mV vs. Ag/AgCl, a shift from butyrate to acetone and butanol production is induced. This leads to an increased final solvent yield of Yᴀᴃᴇ = 0.202 gg⁻¹ (control 0.103 gg⁻¹), which is also reflected in a higher carbon efficiency of 37.6\% compared to 23.3\% (control) as well as a fourfold decrease in simplified E-factor to 0.43. The results are promising for further development of biobutanol production in bioelectrochemical systems in order to fulfil the principles of Green Chemistry.},
  language  = {en}
}
@inproceedings{EssingholtMeyerKuhnetal.2018,
  author    = {Essingholt, Felix and Meyer, Frederic and Kuhn, Peter and Schmidt, Philip and Benkner, Thorsten and Grabmaier, Anton},
  title     = {Non-invasive heart beat measurement using microwave resonators},
  series = {Proceedings, Vol. 2, Eurosensors 2018 Conference, Graz, Austria, 9-12 September 2018},
  booktitle = {Proceedings, Vol. 2, Eurosensors 2018 Conference, Graz, Austria, 9-12 September 2018},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2504-3900},
  doi       = {10.3390/proceedings2131002},
  pages     = {1002},
  year      = {2018},
  language  = {en}
}
@inproceedings{FingerBraunBil2018,
  author    = {Finger, Felix and Braun, Carsten and Bil, Cees},
  title     = {Case studies in initial sizing for hybrid-electric general aviation aircraft},
  series = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio},
  booktitle = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio},
  doi       = {10.2514/6.2018-5005},
  year      = {2018},
  language  = {en}
}
@article{KampkerSchleserTriebsetal.2018,
  author    = {Kampker, Achim and Schleser, Markus and Triebs, Johannes and Berg, Alexander-Karl and Hansen, Jan Ole and Fiedler, Falko},
  title     = {Bauteilintegrierte Vorrichtungsfunktionen im Karosseriebau : Aktuelle Ergebnisse im Forschungsprojekt ProeK},
  series = {ZWF Zeitschrift f{\"u}r wirtschaftlichen Fabrikbetrieb},
  volume    = {113},
  journal   = {ZWF Zeitschrift f{\"u}r wirtschaftlichen Fabrikbetrieb},
  number    = {11},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {0947-0085},
  doi       = {10.3139/104.112012},
  pages     = {767 -- 770},
  year      = {2018},
  abstract  = {Das Forschungsprojekt Produktionseffizienz in der Kleinserie (ProeK) erarbeitet kosteng{\"u}nstige und effiziente L{\"o}sungsans{\"a}tze f{\"u}r Prozessketten im Zukunftsfeld der Elektromobilit{\"a}t. Das Teilprojekt Karosserie setzt diese Zielsetzung durch innovative und praxisorientierte Produkt- und Prozesskonzepte mit neuartigen bauteilintegrierten Vorrichtungsfunktionen (BiV) um. Im Teilprojekt Außenhaut sollen Toleranzen adaptiv durch Anpassungen der Prozessparameter sowie Bauteilmanipulation kompensiert werden.},
  language  = {de}
}
@article{HueningHeuermannWache2018,
  author    = {H{\"u}ning, Felix and Heuermann, Holger and Wache, Franz-Josef},
  title     = {Wireless CAN without WLAN or Bluetooth},
  series = {CAN Newsletter},
  journal   = {CAN Newsletter},
  number    = {December 2018},
  pages     = {44 -- 46},
  year      = {2018},
  abstract  = {In two developed concepts, dual-mode radio enables CAN participants to be integrated wirelessly into a CAN network. Constructed from a few components, a protocol-free, real-time transmission and thus transparent integration into CAN is provided.},
  language  = {en}
}
@inproceedings{FingerBraunBil2018,
  author    = {Finger, Felix and Braun, Carsten and Bil, Cees},
  title     = {An Initial Sizing Methodology for Hybrid-Electric Light Aircraft},
  series = {AIAA AVIATION Forum 2018 Aviation Technology, Integration, and Operations Conference, Atlanta, Georgia, June 25 - 29, 2018},
  booktitle = {AIAA AVIATION Forum 2018 Aviation Technology, Integration, and Operations Conference, Atlanta, Georgia, June 25 - 29, 2018},
  doi       = {10.2514/6.2018-4229},
  year      = {2018},
  language  = {en}
}
@article{BalakirskiKotliarPaulyetal.2018,
  author    = {Balakirski, Galina and Kotliar, Konstantin and Pauly, Karolin J. and Krings, Laura K. and R{\"u}bben, Albert and Baron, Jens M. and Schmitt, Laurenz},
  title     = {Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience},
  series = {Dermatologic Surgery},
  journal   = {Dermatologic Surgery},
  number    = {44 (12)},
  publisher = {Wolters Kluwer},
  doi       = {10.1097/DSS.0000000000001615},
  pages     = {1525 -- 1536},
  year      = {2018},
  abstract  = {BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7\% (19/284) of the cases. In 95\% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13\% to 29\% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.},
  language  = {en}
}
@article{TekinAshikagaHorikawaetal.2018,
  author    = {Tekin, Nurettin and Ashikaga, Mitsugu and Horikawa, Atsushi and Funke, Harald},
  title     = {Enhancement of fuel flexibility of industrial gas turbines by development of innovative hydrogen combustion systems},
  series = {Gas for energy},
  journal   = {Gas for energy},
  number    = {2},
  publisher = {Vulkan-Verlag},
  address   = {Essen},
  pages     = {4},
  year      = {2018},
  abstract  = {For fuel flexibility enhancement hydrogen represents a possible alternative gas turbine fuel within future low emission power generation, in case of hydrogen production by the use of renewable energy sources such as wind energy or biomass. Kawasaki Heavy Industries, Ltd. (KHI) has research and development projects for future hydrogen society; production of hydrogen gas, refinement and liquefaction for transportation and storage, and utilization with gas turbine / gas engine for the generation of electricity. In the development of hydrogen gas turbines, a key technology is the stable and low NOx hydrogen combustion, especially Dry Low Emission (DLE) or Dry Low NOx (DLN) hydrogen combustion. Due to the large difference in the physical properties of hydrogen compared to other fuels such as natural gas, well established gas turbine combustion systems cannot be directly applied for DLE hydrogen combustion. Thus, the development of DLE hydrogen combustion technologies is an essential and challenging task for the future of hydrogen fueled gas turbines. The DLE Micro-Mix combustion principle for hydrogen fuel has been in development for many years to significantly reduce NOx emissions. This combustion principle is based on cross-flow mixing of air and gaseous hydrogen which reacts in multiple miniaturized "diffusion-type" flames. The major advantages of this combustion principle are the inherent safety against flashback and the low NOx-emissions due to a very short residence time of the reactants in the flame region of the micro-flames.},
  language  = {en}
}
@article{GoettenFingerHavermannetal.2018,
  author    = {G{\"o}tten, Falk and Finger, Felix and Havermann, Marc and Braun, Carsten and Gomez, Francisco and Bill, C.},
  title     = {On the flight performance impact of landing gear drag reduction methods for unmanned air vehicles},
  series = {Deutscher Luft- und Raumfahrtkongress 2018},
  journal   = {Deutscher Luft- und Raumfahrtkongress 2018},
  publisher = {DGLR},
  address   = {Bonn},
  doi       = {10.25967/480058},
  pages     = {11 S.},
  year      = {2018},
  abstract  = {The flight performance impact of three different landing gear configurations on a small, fixed-wing UAV is analyzed with a combination of RANS CFD calculations and an incremental flight performance algorithm. A standard fixed landing gear configuration is taken as a baseline, while the influence of retracting the landing gear or applying streamlined fairings is investigated. A retraction leads to a significant parasite drag reduction, while also fairings promise large savings. The increase in lift-to-drag ratio is reduced at high lift coefficients due to the influence of induced drag. All configurations are tested on three different design missions with an incremental flight performance algorithm. A trade-off study is performed using the retracted or faired landing gear's weight increase as a variable. The analysis reveals only small mission performance gains as the aerodynamic improvements are negated by weight penalties. A new workflow for decision-making is presented that allows to estimate if a change in landing gear configuration is beneficial for a small UAV.},
  language  = {en}
}
@inproceedings{LudowicyRingsFingeretal.2018,
  author    = {Ludowicy, Jonas and Rings, Ren{\´e} and Finger, Felix and Braun, Carsten},
  title     = {Sizing Studies of Light Aircraft with Parallel Hybrid Propulsion Systems},
  series = {Deutscher Luft- und Raumfahrtkongress 2018},
  booktitle = {Deutscher Luft- und Raumfahrtkongress 2018},
  doi       = {10.25967/480227},
  pages     = {15 S.},
  year      = {2018},
  language  = {en}
}
@inproceedings{FingerGoettenBraun2018,
  author    = {Finger, Felix and G{\"o}tten, Falk and Braun, Carsten},
  title     = {Initial Sizing for a Family of Hybrid-Electric VTOL General Aviation Aircraft},
  series = {67. Deutscher Luft- und Raumfahrtkongress 2018},
  booktitle = {67. Deutscher Luft- und Raumfahrtkongress 2018},
  pages     = {14 S.},
  year      = {2018},
  language  = {en}
}
@inproceedings{LudowicyRingsFingeretal.2018,
  author    = {Ludowicy, Jonas and Rings, Ren{\´e} and Finger, Felix and Braun, Carsten},
  title     = {Sizing Studies of Light Aircraft with Serial Hybrid Propulsion Systems},
  series = {Luft- und Raumfahrt - Digitalisierung und Vernetzung : Deutscher Luft- und Raumfahrtkongress 2018. 4. - 6. September 2018 - Friedrichshafen},
  booktitle = {Luft- und Raumfahrt - Digitalisierung und Vernetzung : Deutscher Luft- und Raumfahrtkongress 2018. 4. - 6. September 2018 - Friedrichshafen},
  pages     = {11 S.},
  year      = {2018},
  language  = {en}
}
@inproceedings{JenertBarnatDilger2018,
  author    = {Jenert, Tobias and Barnat, Miriam and Dilger, Bernadette},
  title     = {Struktur, Prozess oder Didaktik als Ausgangspunkt? - Ein integratives Modell der Curriculumentwicklung an Hochschule},
  series = {Gelingende Lehre: erkennen, entwickeln, etablieren : Beitr{\"a}ge der Jahrestagung der Deutschen Gesellschaft f{\"u}r Hochschuldidaktik (dghd) 2016},
  booktitle = {Gelingende Lehre: erkennen, entwickeln, etablieren : Beitr{\"a}ge der Jahrestagung der Deutschen Gesellschaft f{\"u}r Hochschuldidaktik (dghd) 2016},
  publisher = {wbv Media},
  address   = {Bielefeld},
  isbn      = {9783763959419},
  pages     = {149 -- 164},
  year      = {2018},
  language  = {de}
}
@article{AlbannaKotliarLuekeetal.2018,
  author    = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander},
  title     = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis},
  series = {Plos one},
  volume    = {13},
  journal   = {Plos one},
  number    = {10},
  publisher = {PLOS},
  address   = {San Francisco},
  doi       = {10.1371/journal.pone.0204689},
  pages     = {e0204689},
  year      = {2018},
  abstract  = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.},
  language  = {en}
}
@inproceedings{ValeroVogelSchmidtetal.2018,
  author    = {Valero, Daniel and Vogel, Jochen and Schmidt, Daniel and Bung, Daniel B.},
  title     = {Three-dimensional flow structure inside the cavity of a non-aerated stepped chute},
  series = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May},
  booktitle = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May},
  isbn      = {978-0-692-13277-7},
  doi       = {10.15142/T3GH17},
  pages     = {12 Seiten},
  year      = {2018},
  language  = {en}
}
@inproceedings{BungTullis2018,
  author    = {Bung, Daniel B. and Tullis, Blake},
  title     = {Hydraulic Structures - ISHS2018 in Perspective},
  series = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May},
  booktitle = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May},
  isbn      = {978-0-692-13277-7},
  doi       = {10.15142/T3WH2B},
  pages     = {9 seiten},
  year      = {2018},
  language  = {en}
}
@incollection{YoshinobuKrauseMiyamotoetal.2018,
  author    = {Yoshinobu, Tatsuo and Krause, Steffi and Miyamoto, Ko-ichiro and Werner, Frederik and Poghossian, Arshak and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {(Bio-)chemical Sensing and Imaging by LAPS and SPIM},
  series = {Label-free biosensing: advanced materials, devices and applications},
  booktitle = {Label-free biosensing: advanced materials, devices and applications},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-75219-8},
  pages     = {103 -- 132},
  year      = {2018},
  abstract  = {The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications.},
  language  = {en}
}
@book{SchoeningPoghossian2018,
  author    = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak},
  title     = {Label-free biosensing: advanced materials, devices and applications},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-75219-8},
  pages     = {xii, 480 Seiten ; Illustrationen, Diagramme},
  year      = {2018},
  language  = {en}
}
@article{RodriguesMoraisNordietal.2018,
  author    = {Rodrigues, Raul T. and Morais, Paulo V. and Nordi, Cristina S. F. and Sch{\"o}ning, Michael Josef and Siqueira Jr., Jos{\´e} R. and Caseli, Luciano},
  title     = {Carbon Nanotubes and Algal Polysaccharides To Enhance the Enzymatic Properties of Urease in Lipid Langmuir-Blodgett Films},
  series = {Langmuir},
  volume    = {34},
  journal   = {Langmuir},
  number    = {9},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {1520-5827},
  doi       = {10.1021/acs.langmuir.7b04317},
  pages     = {3082 -- 3093},
  year      = {2018},
  abstract  = {Algal polysaccharides (extracellular polysaccharides) and carbon nanotubes (CNTs) were adsorbed on dioctadecyldimethylammonium bromide Langmuir monolayers to serve as a matrix for the incorporation of urease. The physicochemical properties of the supramolecular system as a monolayer at the air-water interface were investigated by surface pressure-area isotherms, surface potential-area isotherms, interfacial shear rheology, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to hydrophilic solid supports, quartz, mica, or capacitive electrolyte-insulator-semiconductor (EIS) devices, through the Langmuir-Blodgett (LB) technique, forming mixed films, which were investigated by quartz crystal microbalance, fluorescence spectroscopy, and field emission gun scanning electron microscopy. The enzyme activity was studied with UV-vis spectroscopy, and the feasibility of the thin film as a urea sensor was essayed in an EIS sensor device. The presence of CNT in the enzyme-lipid LB film not only tuned the catalytic activity of urease but also helped to conserve its enzyme activity. Viability as a urease sensor was demonstrated with capacitance-voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results are related to the synergism between the compounds on the active layer, leading to a surface morphology that allowed fast analyte diffusion owing to an adequate molecular accommodation, which also preserved the urease activity. This work demonstrates the feasibility of employing LB films composed of lipids, CNT, algal polysaccharides, and enzymes as EIS devices for biosensing applications.},
  language  = {en}
}
@article{RoehlenPilasDahmenetal.2018,
  author    = {R{\"o}hlen, Desiree and Pilas, Johanna and Dahmen, Markus and Keusgen, Michael and Selmer, Thorsten and Sch{\"o}ning, Michael Josef},
  title     = {Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes},
  series = {Frontiers in Chemistry},
  journal   = {Frontiers in Chemistry},
  number    = {6},
  publisher = {Frontiers},
  address   = {Lausanne},
  doi       = {10.3389/fchem.2018.00284},
  pages     = {Artikel 284},
  year      = {2018},
  abstract  = {Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes.},
  language  = {en}
}
@inproceedings{Pieper2018,
  author    = {Pieper, Martin},
  title     = {Lernzielorientierte Kurse und Stack Aufgaben in der Mathematikausbildung},
  series = {Beitr{\"a}ge zum Mathematikunterricht 2018 : Vortr{\"a}ge zur Mathematikdidaktik und zur Schnittstelle Mathematik/Mathematikdidaktik auf der gemeinsamen Jahrestagung GDM und DMV 2018 (52. Jahrestagung der Gesellschaft f{\"u}r Didaktik der Mathematik). Bd. 3},
  booktitle = {Beitr{\"a}ge zum Mathematikunterricht 2018 : Vortr{\"a}ge zur Mathematikdidaktik und zur Schnittstelle Mathematik/Mathematikdidaktik auf der gemeinsamen Jahrestagung GDM und DMV 2018 (52. Jahrestagung der Gesellschaft f{\"u}r Didaktik der Mathematik). Bd. 3},
  publisher = {WTM-Verlag},
  address   = {M{\"u}nster},
  isbn      = {978-3-95987-089-4},
  pages     = {1399 -- 1402},
  year      = {2018},
  language  = {de}
}
@inproceedings{Pieper2018,
  author    = {Pieper, Martin},
  title     = {Digitale Hochschullehre in mathematischen und mathematikdidaktischen Veranstaltungen},
  series = {Beitr{\"a}ge zum Mathematikunterricht 2018 : Vortr{\"a}ge zur Mathematikdidaktik und zur Schnittstelle Mathematik/Mathematikdidaktik auf der gemeinsamen Jahrestagung GDM und DMV 2018 (52. Jahrestagung der Gesellschaft f{\"u}r Didaktik der Mathematik). Bd. 1},
  booktitle = {Beitr{\"a}ge zum Mathematikunterricht 2018 : Vortr{\"a}ge zur Mathematikdidaktik und zur Schnittstelle Mathematik/Mathematikdidaktik auf der gemeinsamen Jahrestagung GDM und DMV 2018 (52. Jahrestagung der Gesellschaft f{\"u}r Didaktik der Mathematik). Bd. 1},
  publisher = {WTM-Verlag},
  address   = {M{\"u}nster},
  isbn      = {978-3-95987-089-4},
  pages     = {105 -- 106},
  year      = {2018},
  language  = {de}
}
@inproceedings{BungValeroHermens2018,
  author    = {Bung, Daniel B. and Valero, Daniel and Hermens, G.},
  title     = {Hybrid investigation on the hydraulic performance of a new trapezoidal fishway},
  series = {7th IAHR International Symposium on Hydraulic Structures, ISHS 2018},
  booktitle = {7th IAHR International Symposium on Hydraulic Structures, ISHS 2018},
  isbn      = {978-069213277-7},
  doi       = {10.15142/T3S06R},
  pages     = {184 -- 193},
  year      = {2018},
  language  = {de}
}
@incollection{Fissabre2018,
  author    = {Fissabre, Anke},
  title     = {Vom Schiff an Land oder von der Muschel zur Rocaille},
  series = {Schwimmender Barock : Das Schiff als Repr{\"a}sentationsobjekt},
  booktitle = {Schwimmender Barock : Das Schiff als Repr{\"a}sentationsobjekt},
  editor    = {Priesterjahn, Maike},
  publisher = {Bebra Verlag},
  address   = {Berlin},
  isbn      = {978-3-89809-153-4},
  pages     = {59 -- 65},
  year      = {2018},
  language  = {de}
}
@article{MuellerBeckersMussmannetal.2018,
  author    = {M{\"u}ller, Janina and Beckers, Mario and Mußmann, Nina and Bongaerts, Johannes and B{\"u}chs, Jochen},
  title     = {Elucidation of auxotrophic deficiencies of Bacillus pumilus DSM 18097 to develop a defined minimal medium},
  series = {Microbial Cell Factories},
  volume    = {17},
  journal   = {Microbial Cell Factories},
  number    = {1},
  publisher = {BioMed Central},
  issn      = {1475-2859},
  doi       = {10.1186/s12934-018-0956-1},
  pages     = {Article No. 106},
  year      = {2018},
  abstract  = {Background Culture media containing complex compounds like yeast extract or peptone show numerous disadvantages. The chemical composition of the complex compounds is prone to significant variations from batch to batch and quality control is difficult. Therefore, the use of chemically defined media receives more and more attention in commercial fermentations. This concept results in better reproducibility, it simplifies downstream processing of secreted products and enable rapid scale-up. Culturing bacteria with unknown auxotrophies in chemically defined media is challenging and often not possible without an extensive trial-and-error approach. In this study, a respiration activity monitoring system for shake flasks and its recent version for microtiter plates were used to clarify unknown auxotrophic deficiencies in the model organism Bacillus pumilus DSM 18097. Results Bacillus pumilus DSM 18097 was unable to grow in a mineral medium without the addition of complex compounds. Therefore, a rich chemically defined minimal medium was tested containing basically all vitamins, amino acids and nucleobases, which are essential ingredients of complex components. The strain was successfully cultivated in this medium. By monitoring of the respiration activity, nutrients were supplemented to and omitted from the rich chemically defined medium in a rational way, thus enabling a systematic and fast determination of the auxotrophic deficiencies. Experiments have shown that the investigated strain requires amino acids, especially cysteine or histidine and the vitamin biotin for growth. Conclusions The introduced method allows an efficient and rapid identification of unknown auxotrophic deficiencies and can be used to develop a simple chemically defined tailor-made medium. B. pumilus DSM 18097 was chosen as a model organism to demonstrate the method. However, the method is generally suitable for a wide range of microorganisms. By combining a systematic combinatorial approach based on monitoring the respiration activity with cultivation in microtiter plates, high throughput experiments with high information content can be conducted. This approach facilitates media development, strain characterization and cultivation of fastidious microorganisms in chemically defined minimal media while simultaneously reducing the experimental effort.},
  language  = {en}
}