@article{WuBronderPoghossianetal.2014, author = {Wu, Chunsheng and Bronder, Thomas and Poghossian, Arshak and Werner, Frederik and B{\"a}cker, Matthias and Sch{\"o}ning, Michael Josef}, title = {Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips}, series = {Physica status solidi A : Applications and materials science}, volume = {211}, journal = {Physica status solidi A : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330442}, pages = {1423 -- 1428}, year = {2014}, abstract = {A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent-voltage (I-V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I-V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge.}, language = {en} } @article{Wrede1996, author = {Wrede, Oliver}, title = {Mnemotechnik in graphischen Benutzeroberfl{\"a}chen}, series = {Form / Form-Diskurs : Zeitschrift f{\"u}r Design und Theorie. 1 (1996), H. 2}, journal = {Form / Form-Diskurs : Zeitschrift f{\"u}r Design und Theorie. 1 (1996), H. 2}, year = {1996}, language = {en} } @article{Wrede2016, author = {Wrede, Oliver}, title = {Continuity in travel information}, series = {Information Design Journal}, volume = {22}, journal = {Information Design Journal}, number = {2}, publisher = {John Benjamins}, address = {Amsterdam}, issn = {0142-5471}, doi = {10.1075/idj.22.2.09wre}, pages = {172 -- 178}, year = {2016}, abstract = {This article discusses the contrast between the information transportation companies provide to travellers and that of their brand messaging. Companies' brand messaging often portrays the service they provide as pleasant, stress free and perfect. Customers and users of the service, on the other hand, often describe their experience of the service as a negative one. This article suggests that the brand value would be greater if transportation companies paid more attention to the users' experience when designing their information systems, particularly in worst case scenarios.}, language = {en} } @article{WollbrinkMasloZimmeretal.2020, author = {Wollbrink, Moritz and Maslo, Semir and Zimmer, Daniel and Abbas, Karim and Arntz, Kristian and Bergs, Thomas}, title = {Clamping and substrate plate system for continuous additive build-up and post-processing of metal parts}, series = {Procedia CIRP}, volume = {93}, journal = {Procedia CIRP}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2212-8271}, doi = {10.1016/j.procir.2020.04.015}, pages = {108 -- 113}, year = {2020}, abstract = {The manufacturing share of laser powder bed fusion (L-PBF) increases in industrial application, but still many process steps are manually operated. Additionally, it is not possible to achieve tight dimensional tolerances or low surfaces roughness. Hence, a process chain has to be set up to combine additive manufacturing (AM) with further machining technologies. To achieve a continuous workpiece flow as basis for further industrialization of L-PBF, the paper presents a novel substrate system and its application on L-PBF machines and post-processing. The substrate system consists of a zero-point clamping system and a matrix-like interface of contact pins to be substantially connected to the workpiece within the L-PBF process.}, language = {en} } @article{WoliszSchuetzBlankeetal.2017, author = {Wolisz, Henryk and Sch{\"u}tz, Thomas and Blanke, Tobias and Hagenkamp, Markus and Kohrn, Markus and Wesseling, Mark and M{\"u}ller, Dirk}, title = {Cost optimal sizing of smart buildings' energy system components considering changing end-consumer electricity markets}, series = {Energy}, volume = {137}, journal = {Energy}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.energy.2017.06.025}, pages = {715 -- 728}, year = {2017}, language = {en} } @article{WolfSimonSchlick1998, author = {Wolf, Martin R. and Simon, S. and Schlick, Christopher}, title = {Qualitative and Quantitative Analysis of Cooperation / Wolf, M. ; Simon, S. ; Schlick, C.}, series = {Proceedings : May 26 - 29, 1998, Cannes (France) = Actes : 26 - 29 mai 1998 / INRIA, Institut National de Recherche en Informatique et en Automatique, Unit{\´e} de recherche ... F. Darses ..., eds}, journal = {Proceedings : May 26 - 29, 1998, Cannes (France) = Actes : 26 - 29 mai 1998 / INRIA, Institut National de Recherche en Informatique et en Automatique, Unit{\´e} de recherche ... F. Darses ..., eds}, publisher = {-}, address = {Cannes}, pages = {1 -- 5}, year = {1998}, language = {en} } @article{WolfSchlickSpringer1997, author = {Wolf, Martin R. and Schlick, Christopher and Springer, J.}, title = {The use of implicit communication mechanisms in desktop-teleconferencing-systems}, series = {Proceedings of WWDU '97 Tokyo, Fifth International Scientific Conference on Work with Display Units : November 3 - 5, 1997, Tokyo}, journal = {Proceedings of WWDU '97 Tokyo, Fifth International Scientific Conference on Work with Display Units : November 3 - 5, 1997, Tokyo}, editor = {Miyamoto, Hiroyuki}, publisher = {-}, address = {Tokyo}, pages = {193 -- 194}, year = {1997}, language = {en} } @article{WolfLuczakSpringeretal.1997, author = {Wolf, Martin R. and Luczak, Holger and Springer, J. and Simon, S.}, title = {The role of metaphors in computer supported cooperative work}, series = {Proceedings of WWDU '97 Tokyo, Fifth International Scientific Conference on Work with Display Units : November 3 - 5, 1997, Tokyo /}, journal = {Proceedings of WWDU '97 Tokyo, Fifth International Scientific Conference on Work with Display Units : November 3 - 5, 1997, Tokyo /}, editor = {Miyamoto, Hiroyuki}, publisher = {-}, address = {Tokyo}, pages = {191 -- 192}, year = {1997}, language = {en} } @article{WolfLuczak1999, author = {Wolf, Martin R. and Luczak, Holger}, title = {Computer Supported Communication and Cooperation - Making Information Aware / Luczak, H. ; Wolf, M.}, series = {Human-computer interaction : proceedings of HCI International '99 (the 8th International Conference on Human-Computer Interaction), Munich, Germany, August 22 - 26, 1999}, journal = {Human-computer interaction : proceedings of HCI International '99 (the 8th International Conference on Human-Computer Interaction), Munich, Germany, August 22 - 26, 1999}, publisher = {Erlbaum}, address = {Mahwah, NJ}, pages = {298 -- 302}, year = {1999}, language = {en} } @article{WolfFoltzSchlicketal.2000, author = {Wolf, Martin R. and Foltz, Christian and Schlick, Christopher and Luczak, Holger}, title = {Empirical Investigation of a workspace model for Chemical engineers / Wolf, Martin ; Foltz, Christian ; Schlick, Christopher ; Luczak, Holger}, series = {Proceedings of the Human Factors and Ergonomics Society Annual Meeting July 2000. 44 (2000), H. 6}, journal = {Proceedings of the Human Factors and Ergonomics Society Annual Meeting July 2000. 44 (2000), H. 6}, publisher = {-}, pages = {612 -- 615}, year = {2000}, language = {en} } @article{WolfFoltzSchlicketal.1999, author = {Wolf, Martin R. and Foltz, Christian and Schlick, Christopher and Luczak, Holger}, title = {Groupware support for chemical process design / Wolf, M.; Foltz, C.; Schlick, C.; Luczak, H.}, series = {Human-computer interaction : proceedings of HCI International '99 (the 8th International Conference on Human-Computer Interaction), Munich, Germany, August 22 - 26, 1999}, journal = {Human-computer interaction : proceedings of HCI International '99 (the 8th International Conference on Human-Computer Interaction), Munich, Germany, August 22 - 26, 1999}, publisher = {Erlbaum}, address = {Mahwah, NJ}, pages = {343 -- 347}, year = {1999}, language = {en} } @article{WolfFoltzSchlicketal.2002, author = {Wolf, Martin R. and Foltz, Christian and Schlick, Christopher and Luczak, Holger}, title = {Development and evaluation of a groupware system to support chemical design processes / Wolf, Martin ; Foltz, Christian ; Schlick, Christopher ; Luczak, Holger}, series = {International Journal of Human-Computer Interaction . 14 (2002), H. 2}, journal = {International Journal of Human-Computer Interaction . 14 (2002), H. 2}, publisher = {-}, isbn = {1044-7318}, pages = {181 -- 198}, year = {2002}, language = {en} } @article{WolfFoltzKillichetal.2001, author = {Wolf, Martin R. and Foltz, Christian and Killich, Stephan and Schmidt, Ludger}, title = {Task and Information Modeling for Cooperative Work / Foltz, Christian ; Killich, Stephan ; Wolf, Martin ; Schmidt, Ludger ; Luczak, Holger}, series = {Systems, social and internationalization design aspects of human-computer interaction / ed. by Michael J. Smith, Gavriel Salvendy Vol. 2}, journal = {Systems, social and internationalization design aspects of human-computer interaction / ed. by Michael J. Smith, Gavriel Salvendy Vol. 2}, publisher = {-}, isbn = {0-8058-3608-X}, pages = {172 -- 176}, year = {2001}, language = {en} } @article{Wolf2000, author = {Wolf, Martin R.}, title = {Groupware related task design}, series = {ACM SIGGROUP Bulletin}, volume = {21}, journal = {ACM SIGGROUP Bulletin}, number = {2}, issn = {2372-7403}, doi = {10.1145/605660.605662}, pages = {5 -- 8}, year = {2000}, abstract = {his report summarizes the results of a workshop on Groupware related task design which took place at the International Conference on Supporting Group Work Group'99, Arizona, from 14 th to 17 th November 1999. The workshop was addressed to people from different viewpoints, backgrounds, and domains: - Researchers dealing with questions of task analysis and task modeling for Groupware application from an academic point of view. They may contribute modelbased design approaches or theoretically oriented work - Practitioners with experience in the design and everyday use of groupware systems. They might refer to the practical side of the topic: "real" tasks, "real" problems, "real" users, etc.}, language = {en} } @article{Wolf2000, author = {Wolf, Martin R.}, title = {Groupware related task design}, series = {ACM SIGGROUP Bulletin. 21 (2000), H. 2}, journal = {ACM SIGGROUP Bulletin. 21 (2000), H. 2}, publisher = {-}, pages = {5 -- 8}, year = {2000}, language = {en} } @article{WittmannUlamecFeuerbacheretal.1997, author = {Wittmann, Klaus and Ulamec, S. and Feuerbacher, B. and Rosenbauer, H. (u.a.)}, title = {Rosetta Lander - In Situ Investigation of a Cometary Nucleus}, series = {Lunar and Planetary Science. 28 (1997)}, journal = {Lunar and Planetary Science. 28 (1997)}, isbn = {0270-9511}, pages = {1461 -- 1462}, year = {1997}, language = {en} } @article{WittmannUlamecFeuerbacheretal.1995, author = {Wittmann, Klaus and Ulamec, S. and Feuerbacher, B. and Rosenbauer, H.}, title = {Technical Challenge, Scientific Thrill: A Long Term Lander on an Active Comet}, series = {Lunar and Planetary Science. 26 (1995)}, journal = {Lunar and Planetary Science. 26 (1995)}, isbn = {0270-9511}, pages = {1431 -- 1432}, year = {1995}, language = {en} } @article{WittmannUlamecRichter1999, author = {Wittmann, Klaus and Ulamec, S and Richter, L}, title = {Lander Systems for Planetary Missions}, series = {Laboratory astrophysics and space research / ed. by P. Ehrenfreund}, journal = {Laboratory astrophysics and space research / ed. by P. Ehrenfreund}, publisher = {Kluwer}, address = {Dordrecht [u.a.]}, isbn = {0-7923-5338-2}, pages = {597 -- 621}, year = {1999}, language = {en} } @article{WittmannSchmidtPadekenetal.1988, author = {Wittmann, Klaus and Schmidt, H. P. and Padeken, D. and Hildmann, B.}, title = {The Microgravity User Support Centre (MUSC)}, series = {ESA SP. 277 (1988)}, journal = {ESA SP. 277 (1988)}, isbn = {0379-6566}, pages = {525}, year = {1988}, language = {en} } @article{WittmannSchmidtFeuerbacher1988, author = {Wittmann, Klaus and Schmidt, H. P. and Feuerbacher, B.}, title = {Microgravity research and user support in the Space Station era: The Microgravity User Support Centre}, series = {Acta Astronautica. 17 (1988), H. 11-12}, journal = {Acta Astronautica. 17 (1988), H. 11-12}, isbn = {0094-5765}, pages = {1161 -- 1168}, year = {1988}, language = {en} } @article{WittmannPadeken1993, author = {Wittmann, Klaus and Padeken, D.}, title = {The User Center for Microgravity MUSC - Support for space experiments}, series = {DLR-Nachrichten. 70 (1993)}, journal = {DLR-Nachrichten. 70 (1993)}, isbn = {0937-0420}, pages = {19 -- 24}, year = {1993}, language = {en} } @article{WittmannKellWinkleretal.1998, author = {Wittmann, Klaus and Kell, G. and Winkler, F. and G{\"u}nther, M. (u.a.)}, title = {High resolution temperature measurement technique for materials sciences experiments in space}, series = {Acta Astronautica. 43 (1998), H. 7-8}, journal = {Acta Astronautica. 43 (1998), H. 7-8}, isbn = {0094-5765}, pages = {385 -- 395}, year = {1998}, language = {en} } @article{WittmannKehrWillnecker2000, author = {Wittmann, Klaus and Kehr, J. and Willnecker, R.}, title = {Decentralized Payload Operations Concept for Columbus}, year = {2000}, language = {en} } @article{WittmannGillessenOttoetal.1996, author = {Wittmann, Klaus and Gillessen, F. and Otto, G. and R{\"o}stel, R.}, title = {Undercooling and solidification of metallic melts suspended in a non-nucleating matrix: Experiment NUCAL of the German Spacelab Mission D-2}, series = {Acta Astronautica. 38 (1996), H. 1}, journal = {Acta Astronautica. 38 (1996), H. 1}, isbn = {0094-5765}, pages = {63 -- 68}, year = {1996}, language = {en} } @article{WittmannFortezza1992, author = {Wittmann, Klaus and Fortezza, R.}, title = {Telescience opportunities in the precursor flights}, series = {Space Technology - Industrial and Commercial Applications. 13 (1992), H. 2}, journal = {Space Technology - Industrial and Commercial Applications. 13 (1992), H. 2}, isbn = {0892-9270}, pages = {221 -- 226}, year = {1992}, language = {en} } @article{WittmannFeuerbacherUlamecetal.1999, author = {Wittmann, Klaus and Feuerbacher, B. and Ulamec, S. and Rosenbauer, H. (u.a.)}, title = {Rosetta Lander - In Situ Characterisation of a Comet Nucleus}, series = {Acta Astronautica. 45 (1999), H. 4-9}, journal = {Acta Astronautica. 45 (1999), H. 4-9}, isbn = {0094-5765}, pages = {389 -- 395}, year = {1999}, language = {en} } @article{WittmannBibringRosenbaueretal.2007, author = {Wittmann, Klaus and Bibring, J.-P. and Rosenbauer, H. and Boehnhardt, H.}, title = {The Rosetta Lander ("Philae") Investigations / Bibring, J.-P. ; Rosenbauer, H. ; Boehnhardt, H. ; [...] Wittmann, K.}, series = {Space Science Reviews. 128 (2007), H. 1-4}, journal = {Space Science Reviews. 128 (2007), H. 1-4}, isbn = {0038-6308}, pages = {205 -- 220}, year = {2007}, language = {en} } @article{WittmannBewersdorffGoerleretal.1993, author = {Wittmann, Klaus and Bewersdorff, A. and G{\"o}rler, G.P. and Otto, G.}, title = {Solidification of silver-germanium alloys in an amorphous matrix aboard the space station Mir}, series = {Acta Astronautica. 29 (1993), H. 7}, journal = {Acta Astronautica. 29 (1993), H. 7}, isbn = {0094-5765}, pages = {547 -- 552}, year = {1993}, language = {en} } @article{Wittmann1993, author = {Wittmann, Klaus}, title = {The microgravity User Support Centre}, series = {Space Technology - Industrial and Commercial Applications. 13 (1993), H. 2}, journal = {Space Technology - Industrial and Commercial Applications. 13 (1993), H. 2}, isbn = {0892-9270}, pages = {121 -- 124}, year = {1993}, language = {en} } @article{Wittmann2000, author = {Wittmann, Klaus}, title = {Overview of Space Operations at DLR}, year = {2000}, language = {en} } @article{WissenbachSixBongaertsetal.1995, author = {Wissenbach, U. and Six, S. and Bongaerts, Johannes and Ternes, D. and Steinwachs, S. and Unden, G.}, title = {A third periplasmic transport system for l-arginine in Escherichia coli: molecular characterization of the artPIQMJ genes, arginine binding and transport}, series = {Molecular microbiology}, volume = {Vol. 17}, journal = {Molecular microbiology}, number = {Iss. 4}, issn = {1365-2958 (E-Journal); 0950-382x (Print)}, pages = {675 -- 686}, year = {1995}, language = {en} } @article{WissenBogdanskiScheeretal.2005, author = {Wissen, M. and Bogdanski, N. and Scheer, H.-C. and Bitz, Andreas and Ahrens, G. and Gruetzner, G.}, title = {Implication of the light polarisation for UV curing of pre-patterned resists}, series = {Microelectronic Engineering}, volume = {78-79}, journal = {Microelectronic Engineering}, issn = {0167-9317}, doi = {10.1016/j.mee.2004.12.099}, pages = {659 -- 664}, year = {2005}, language = {en} } @article{WindmuellerSchapsZantisetal.2024, author = {Windm{\"u}ller, Anna and Schaps, Kristian and Zantis, Frederik and Domgans, Anna and Taklu, Bereket Woldegbreal and Yang, Tingting and Tsai, Chih-Long and Schierholz, Roland and Yu, Shicheng and Kungl, Hans and Tempel, Hermann and Dunin-Borkowski, Rafal E. and H{\"u}ning, Felix and Hwang, Bing Joe and Eichel, R{\"u}diger-A.}, title = {Electrochemical activation of LiGaO2: implications for ga-doped garnet solid electrolytes in li-metal batteries}, series = {ACS Applied Materials \& Interfaces}, volume = {16}, journal = {ACS Applied Materials \& Interfaces}, number = {30}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {39181-3919}, doi = {10.1021/acsami.4c03729}, pages = {14 Seiten}, year = {2024}, abstract = {Ga-doped Li7La3Zr2O12 garnet solid electrolytes exhibit the highest Li-ion conductivities among the oxide-type garnet-structured solid electrolytes, but instabilities toward Li metal hamper their practical application. The instabilities have been assigned to direct chemical reactions between LiGaO2 coexisting phases and Li metal by several groups previously. Yet, the understanding of the role of LiGaO2 in the electrochemical cell and its electrochemical properties is still lacking. Here, we are investigating the electrochemical properties of LiGaO2 through electrochemical tests in galvanostatic cells versus Li metal and complementary ex situ studies via confocal Raman microscopy, quantitative phase analysis based on powder X-ray diffraction, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and electron energy loss spectroscopy. The results demonstrate considerable and surprising electrochemical activity, with high reversibility. A three-stage reaction mechanism is derived, including reversible electrochemical reactions that lead to the formation of highly electronically conducting products. The results have considerable implications for the use of Ga-doped Li7La3Zr2O12 electrolytes in all-solid-state Li-metal battery applications and raise the need for advanced materials engineering to realize Ga-doped Li7La3Zr2O12for practical use.}, language = {en} } @article{WincklerKruegerSchnitzleretal.2014, author = {Winckler, Silvia and Krueger, Rolf and Schnitzler, Thomas and Zang, Werner and Fischer, Rainer and Biselli, Manfred}, title = {A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach}, series = {Bioprocess and biosystems engineering}, volume = {37}, journal = {Bioprocess and biosystems engineering}, number = {5}, publisher = {Springer}, address = {Berlin, Heidelberg}, issn = {1615-7591 (Print) 1615-7605 (Online)}, doi = {10.1007/s00449-013-1062-8}, pages = {901 -- 912}, year = {2014}, abstract = {Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.}, language = {en} } @article{WilsonBlomeLaFave1996, author = {Wilson, Thomas L and Blome, Hans-Joachim and LaFave, Norman}, title = {Astrophysical Cosmology Using a Lunar Ligo}, series = {Engineering, construction, and operations in space V : proceedings of the Fifth International Conference on Space '96, Albuquerque, New Mexico, June 1-6, 1996 / sponsored by Aerospace Division of the American Society of Civil Engineers ... [et al.]; edite}, journal = {Engineering, construction, and operations in space V : proceedings of the Fifth International Conference on Space '96, Albuquerque, New Mexico, June 1-6, 1996 / sponsored by Aerospace Division of the American Society of Civil Engineers ... [et al.]; edite}, publisher = {The Society}, address = {New York}, isbn = {0-7844-0177-2}, pages = {861 -- 863}, year = {1996}, language = {en} } @article{WilsonBlome2009, author = {Wilson, T. L. and Blome, Hans-Joachim}, title = {The Pioneer anomaly and a rotating G{\"o}del universe}, series = {Advances in Space Research}, volume = {44}, journal = {Advances in Space Research}, number = {11}, isbn = {0273-1177}, pages = {1345 -- 1353}, year = {2009}, language = {en} } @article{WilsonWilsonScheeretal.2017, author = {Wilson, Ian D. and Wilson, Claire E. and Scheer, Nico and Dickie, A.P. and Schreiter, K. and Wilson, E. M. and Riley, R. J. and Wehr, R. and Bial, J.}, title = {The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice}, series = {Biochemical pharmacology}, volume = {Volume 135}, journal = {Biochemical pharmacology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-2968}, doi = {10.1016/j.bcp.2017.03.015}, pages = {139 -- 150}, year = {2017}, language = {en} } @article{WilsonDickieSchreiteretal.2018, author = {Wilson, C. E. and Dickie, A. P. and Schreiter, K. and Wehr, R. and Wilson, E. M. and Bial, J. and Scheer, Nico and Wilson, I. D. and Riley, R. J.}, title = {The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice}, series = {Archives of Toxicology}, volume = {92}, journal = {Archives of Toxicology}, number = {6}, publisher = {Springer}, issn = {1432-0738}, doi = {10.1007/s00204-018-2212-1}, pages = {1953 -- 1967}, year = {2018}, abstract = {The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.}, language = {en} } @article{WilmingBegemannKuhneetal.2013, author = {Wilming, Anja and Begemann, Jens and Kuhne, Stefan and Regestein, Lars and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and B{\"u}chs, Jochen}, title = {Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations}, series = {Biochemical engineering journal}, volume = {Vol. 73}, journal = {Biochemical engineering journal}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-295X (E-Journal); 1369-703X (Print)}, pages = {29 -- 37}, year = {2013}, language = {en} } @article{Wilke2017, author = {Wilke, Thomas}, title = {Newly found plans for the chapel of the Holy Shroud}, series = {Studi Piemontesi}, volume = {XLVI}, journal = {Studi Piemontesi}, number = {1}, issn = {0392-7261}, pages = {75 -- 85}, year = {2017}, language = {en} } @article{WildSchrezenmeierCzupallaetal.2020, author = {Wild, Dominik and Schrezenmeier, Johannes and Czupalla, Markus and F{\"o}rstner, Roger}, title = {Thermal Characterization of additive manufactured Integral Structures for Phase Change Applications}, series = {2020 International Conference on Environmental Systems}, journal = {2020 International Conference on Environmental Systems}, publisher = {Texas Tech University}, year = {2020}, abstract = {"Infused Thermal Solutions" (ITS) introduces a method for passive thermal control to stabilize structural components thermally without active heating and cooling systems, by using phase change material (PCM) in combination with lattice - both embedded into an additive manufactured integral structure. The technology is currently under development. This paper presents the results of the thermal property measurements performed on additive manufactured ITS breadboards. Within the breadboard campaigns key characteristics of the additive manufactured specimens were derived: Mechanical parameters: specimen impermeability, minimum wall thickness, lattice structure, subsequent heat treatment. Thermal properties: thermo-optical surface properties of the additive manufactured raw material, thermal conductivity and specific heat capacity measurements. As a conclusion the paper introduces an overview of potential ITS hardware applications, expected to increase the thermal performance.}, language = {en} } @article{WiesenTippkoetterMuffleretal.2015, author = {Wiesen, Sebastian and Tippk{\"o}tter, Nils and Muffler, Kai and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland}, title = {Adsorption of fatty acids to layered double hydroxides in aqueous systems}, series = {Adsorption}, volume = {21}, journal = {Adsorption}, number = {6-7}, publisher = {Springer}, address = {Berlin}, pages = {459 -- 466}, year = {2015}, abstract = {Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L-1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32-.}, language = {en} } @article{WiegandVoigtAlbrechtetal.2013, author = {Wiegand, Sandra and Voigt, Birgit and Albrecht, Dirk and Bongaerts, Johannes and Evers, Stefan and Hecker, Michael and Daniel, Rolf and Liesegang, Heiko}, title = {Fermentation stage-dependent adaptations of Bacillus licheniformis during enzyme production}, series = {Microbial Cell Factories}, volume = {12}, journal = {Microbial Cell Factories}, publisher = {Biomed Central}, address = {London}, issn = {1475-2859}, doi = {10.1186/1475-2859-12-120}, pages = {120}, year = {2013}, language = {en} } @article{WiegandDietrichHerteletal.2013, author = {Wiegand, Sandra and Dietrich, Sascha and Hertel, Robert and Bongaerts, Johannes and Evers, Stefan and Volland, Sonja and Daniel, Rolf and Liesegang, Heiko}, title = {RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation}, series = {BMC genomics}, volume = {Vol. 14}, journal = {BMC genomics}, publisher = {BioMed Central}, address = {London}, issn = {1471-2164}, pages = {667}, year = {2013}, language = {en} } @article{WhiteheadOehlschlaegerAlmajhdietal.2014, author = {Whitehead, Mark and {\"O}hlschl{\"a}ger, Peter and Almajhdi, Fahad N. and Alloza, Leonor and Marz{\´a}bal, Pablo and Meyers, Ann E. and Hitzeroth, Inga I. and Rybicki, Edward P.}, title = {Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice}, series = {BMC cancer}, journal = {BMC cancer}, number = {14:367}, publisher = {BioMed Central}, address = {London}, issn = {1471-2407}, doi = {10.1186/1471-2407-14-367}, pages = {1 -- 15}, year = {2014}, language = {en} } @article{WertIkenSchoeningetal.2021, author = {Wert, Stefan and Iken, Heiko and Sch{\"o}ning, Michael Josef and Matysik, Frank-Michael}, title = {Development of a temperature-pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy}, series = {Electroanalysis}, journal = {Electroanalysis}, number = {Early View}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.202100089}, year = {2021}, abstract = {Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating.}, language = {en} } @article{WernerWagnerYoshinobuetal.2013, author = {Werner, Frederik and Wagner, Torsten and Yoshinobu, Tatsuo and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Frequency behaviour of light-addressable potentiometric sensors}, series = {Physica Status Solidi (A)}, volume = {210}, journal = {Physica Status Solidi (A)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X ; 0031-8965}, doi = {10.1002/pssa.201200929}, pages = {884 -- 891}, year = {2013}, abstract = {Light-addressable potentiometric sensors (LAPS) are semiconductor-based potentiometric sensors, with the advantage to detect the concentration of a chemical species in a liquid solution above the sensor surface in a spatially resolved manner. The addressing is achieved by a modulated and focused light source illuminating the semiconductor and generating a concentration-depending photocurrent. This work introduces a LAPS set-up that is able to monitor the electrical impedance in addition to the photocurrent. The impedance spectra of a LAPS structure, with and without illumination, as well as the frequency behaviour of the LAPS measurement are investigated. The measurements are supported by electrical equivalent circuits to explain the impedance and the LAPS-frequency behaviour. The work investigates the influence of different parameters on the frequency behaviour of the LAPS. Furthermore, the phase shift of the photocurrent, the influence of the surface potential as well as the changes of the sensor impedance will be discussed.}, language = {en} } @article{WernerWagnerMiyamotoetal.2012, author = {Werner, Frederik and Wagner, Torsten and Miyamoto, Ko-ichiro and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up}, series = {Sensors and Actuators B: Chemical}, volume = {175}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2011.12.102}, pages = {118 -- 122}, year = {2012}, abstract = {Light-addressable potentiometric sensors (LAPS) are field-effect-based sensors. A modulated light source is used to define the particular measurement spot to perform spatially resolved measurements of chemical species and to generate chemical images. In this work, an organic-LED (OLED) display has been chosen as a light source. This allows high measurement resolution and miniaturisation of the system. A new developed driving method for the OLED display optimised for LAPS-based measurements is demonstrated. The new method enables to define modulation frequencies between 1 kHz and 16 kHz and hence, reduces the measurement time of a chemical image by a factor of 40 compared to the traditional addressing of an OLED display.}, language = {en} } @article{WernerWagnerMiyamotoetal.2011, author = {Werner, Frederik and Wagner, Torsten and Miyamoto, Ko-ichiro and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up}, series = {Procedia Engineering. 25 (2011)}, journal = {Procedia Engineering. 25 (2011)}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1877-7058}, pages = {346 -- 349}, year = {2011}, language = {en} } @article{WernerTakenagaTakietal.2013, author = {Werner, Frederik and Takenaga, Shoko and Taki, Hidenori and Sawada, Kazuaki and Sch{\"o}ning, Michael Josef}, title = {Comparison of label-free ACh-imaging sensors based on CCD and LAPS}, series = {Sensors and Actuators B: Chemical (2012)}, volume = {177}, journal = {Sensors and Actuators B: Chemical (2012)}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0925-4005}, pages = {745 -- 752}, year = {2013}, abstract = {Semiconductor-based chemical imaging sensors, like the light-addressable potentiometric sensor (LAPS) or the pH-imaging sensor based on a charge-coupled device (CCD), are becoming a powerful tool for label-free imaging of biological phenomena. We have proposed a polyion-based enzymatic membrane to develop an acetylcholine (ACh) imaging sensor for neural cell-activity observations. In this study, a CCD-type ACh-imaging sensor and a LAPS-type ACh-imaging sensor were fabricated and the prospect of both sensors was clarified by making a comparison of their basic characteristics.}, language = {en} }