@article{FrotscherMuanghongDursunetal.2016, author = {Frotscher, Ralf and Muanghong, Danita and Dursun, G{\"o}zde and Goßmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Staat, Manfred}, title = {Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue}, series = {Journal of Biomechanics}, volume = {49}, journal = {Journal of Biomechanics}, number = {12}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9290 (Print)}, doi = {10.1016/j.jbiomech.2016.01.039}, pages = {2428 -- 2435}, year = {2016}, abstract = {We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.}, language = {en} } @article{GossmannFrotscherLinderetal.2016, author = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells}, series = {Cellular physiology and biochemistry}, volume = {38}, journal = {Cellular physiology and biochemistry}, number = {3}, publisher = {Karger}, address = {Basel}, issn = {1421-9778 (Online)}, doi = {10.1159/000443124}, pages = {1182 -- 1198}, year = {2016}, abstract = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.}, language = {en} } @inproceedings{PeloniCeriottiDachwald2015, author = {Peloni, A. and Ceriotti, M. and Dachwald, Bernd}, title = {Preliminary trajectory design of a multiple NEO rendezvous mission through solar sailing}, series = {Proceedings of the International Astronautical Congress, IAC, Vol. 8, 2014}, booktitle = {Proceedings of the International Astronautical Congress, IAC, Vol. 8, 2014}, publisher = {Curran}, address = {Red Hook, NY}, isbn = {978-1-63439-986-9}, pages = {5352 -- 5366}, year = {2015}, language = {en} } @article{HauserKotliarTholenetal.2015, author = {Hauser, C. and Kotliar, Konstantin and Tholen, S. and Hasenau, A. and Suttmann, Y. and Renders, L. and Heemann, U. and Baumann, M. and Schmaderer, C.}, title = {Dynamische retinale Gef{\"a}ßreaktion bei H{\"a}modialysepatienten}, series = {Nieren- und Hochdruckkrankheiten}, volume = {44}, journal = {Nieren- und Hochdruckkrankheiten}, number = {11}, publisher = {Dustri-Verlag}, address = {Oberhaching}, issn = {0300-5224}, doi = {10.5414/NHX01743a}, pages = {480 -- 480}, year = {2015}, language = {de} } @incollection{DigelSadykovTemizArtmannetal.2015, author = {Digel, Ilya and Sadykov, R. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations}, series = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies}, booktitle = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies}, publisher = {Nova Science Publ.}, isbn = {9781634826990}, pages = {75 -- 99}, year = {2015}, language = {en} } @inproceedings{PirovanoSeefeldtDachwaldetal.2015, author = {Pirovano, Laura and Seefeldt, Patric and Dachwald, Bernd and Noomen, Ron}, title = {Attitude and Orbital Dynamics Modeling for an Uncontrolled Solar-Sail Experiment in Low-Earth Orbit}, series = {25th International Symposium on Spaceflight Dynamics, 2015, Munich, Germany}, booktitle = {25th International Symposium on Spaceflight Dynamics, 2015, Munich, Germany}, pages = {15 S.}, year = {2015}, language = {en} } @inproceedings{GrundmannBauerBieleetal.2015, author = {Grundmann, Jan Thimo and Bauer, Waldemar and Biele, Jens and Cordero, Frederico and Dachwald, Bernd and Koncz, Alexander and Krause, Christian and Mikschl, Tobias and Montenegro, Sergio and Quantius, Dominik and Ruffer, Michael and Sasaki, Kaname and Schmitz, Nicole and Seefeldt, Patric and T{\´o}th, Norbert and Wejmo, Elisabet}, title = {From Sail to Soil - Getting Sailcraft Out of the Harbour on a Visit to One of Earth's Nearest Neighbours}, series = {4th IAA Planetary Denfense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy}, booktitle = {4th IAA Planetary Denfense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy}, pages = {20 S.}, year = {2015}, language = {en} } @article{GrundmannDachwaldGrimmetal.2015, author = {Grundmann, Jan Thimo and Dachwald, Bernd and Grimm, Christian D. and Kahle, Ralph and Koch, Aaron Dexter and Krause, Christian and Lange, Caroline and Quantius, Dominik and Ulamec, Stephan}, title = {Spacecraft for Hypervelocity Impact Research - An Overview of Capabilities, Constraints and the Challenges of Getting There}, series = {Procedia Engineering}, volume = {Vol. 103}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2015.04.021}, pages = {151 -- 158}, year = {2015}, language = {en} } @article{KowalskiLinderZierkeetal.2016, author = {Kowalski, Julia and Linder, Peter and Zierke, S. and Wulfen, B. van and Clemens, J. and Konstantinidis, K. and Ameres, G. and Hoffmann, R. and Mikucki, J. and Tulaczyk, S. and Funke, O. and Blandfort, D. and Espe, Clemens and Feldmann, Marco and Francke, Gero and Hiecker, S. and Plescher, Engelbert and Sch{\"o}ngarth, Sarah and Dachwald, Bernd and Digel, Ilya and Artmann, Gerhard and Eliseev, D. and Heinen, D. and Scholz, F. and Wiebusch, C. and Macht, S. and Bestmann, U. and Reineking, T. and Zetzsche, C. and Schill, K. and F{\"o}rstner, R. and Niedermeier, H. and Szumski, A. and Eissfeller, B. and Naumann, U. and Helbing, K.}, title = {Navigation technology for exploration of glacier ice with maneuverable melting probes}, series = {Cold Regions Science and Technology}, journal = {Cold Regions Science and Technology}, number = {123}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0165-232X}, doi = {10.1016/j.coldregions.2015.11.006}, pages = {53 -- 70}, year = {2016}, abstract = {The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.}, language = {en} } @article{DuongNguyenStaat2015, author = {Duong, Minh Tuan and Nguyen, Nhu Huynh and Staat, Manfred}, title = {Physical response of hyperelastic models for composite materials and soft tissues}, series = {Asia pacific journal on computational engineering}, volume = {2}, journal = {Asia pacific journal on computational engineering}, number = {3 (December 2015)}, issn = {2196-1166}, doi = {10.1186/s40540-015-0015-x}, pages = {1 -- 18}, year = {2015}, language = {en} } @inproceedings{FrotscherDuongStaat2015, author = {Frotscher, Ralf and Duong, Minh Tuan and Staat, Manfred}, title = {Simulating beating cardiomyocytes with electromechanical coupling}, series = {II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)}, booktitle = {II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)}, organization = {International Conference on Biomedical Technology <2, 2015, Hannover>}, pages = {1 -- 2}, year = {2015}, language = {en} } @inproceedings{PeloniCeriottiDachwald2015, author = {Peloni, Alessandro and Ceriotti, Matteo and Dachwald, Bernd}, title = {Solar-Sailing Trajectory Design for Close-up NEA Observations Mission}, series = {4th IAA Planetary Defense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy}, booktitle = {4th IAA Planetary Defense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy}, pages = {21 S.}, year = {2015}, language = {de} } @article{CehreliAkpinarTemizArtmannetal.2015, author = {Cehreli, Ruksan and Akpinar, Hale and Temiz Artmann, Ayseg{\"u}l and Sagol, Ozgul}, title = {Effects of Glutamine and Omega-3 Fatty Acids on Erythrocyte Deformability and Oxidative Damage in Rat Model of Enterocolitis}, series = {Gastroenterology Research}, volume = {8}, journal = {Gastroenterology Research}, number = {5}, issn = {1918-2813}, doi = {10.14740/gr683w}, pages = {265 -- 273}, year = {2015}, language = {en} } @inproceedings{PhamStaat2015, author = {Pham, Phu Tinh and Staat, Manfred}, title = {A simplification for shakedown analysis of hardening structures}, series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, publisher = {RWTH Aachen University}, address = {Aachen}, organization = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>}, pages = {1 -- 4}, year = {2015}, language = {en} } @inproceedings{DuongNguyenStaat2015, author = {Duong, Minh Tuan and Nguyen, N. H. and Staat, Manfred}, title = {Modeling and simulation of a growing mass by the Smoothed Finite Element Method (SFEM)}, series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, publisher = {RWTH Aachen University}, address = {Aachen}, organization = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>}, pages = {1 -- 4}, year = {2015}, language = {en} } @inproceedings{BhattaraiFrotscherStaat2015, author = {Bhattarai, Aroj and Frotscher, Ralf and Staat, Manfred}, title = {Biomechanical study of the female pelvic floor dysfunction using the finite element method}, series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, publisher = {RWTH Aachen University}, address = {Aachen}, organization = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>}, pages = {1 -- 4}, year = {2015}, language = {en} } @inproceedings{FrotscherStaat2015, author = {Frotscher, Ralf and Staat, Manfred}, title = {An electromechanical model for cardiac tissue constructs}, series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, publisher = {RWTH Aachen University}, address = {Aachen}, organization = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>}, pages = {1 -- 4}, year = {2015}, language = {en} } @article{DuongNguyenTranetal.2015, author = {Duong, Minh Tuan and Nguyen, Nhu Huynh and Tran, Thanh Ngoc and Tolba, R. H. and Staat, Manfred}, title = {Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen}, series = {International biomechanics}, volume = {Vol. 2}, journal = {International biomechanics}, number = {Iss. 1}, publisher = {Taylor \& Francis}, address = {London}, issn = {2333-5432}, doi = {10.1080/23335432.2015.1049295}, pages = {79 -- 88}, year = {2015}, language = {en} } @inproceedings{FrotscherStaat2015, author = {Frotscher, Ralf and Staat, Manfred}, title = {Homogenization of a cardiac tissue construct}, series = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France}, booktitle = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France}, editor = {Nithiarasu, Perumal}, publisher = {CMBE}, address = {[s.l.]}, issn = {2227-9385}, pages = {645 -- 648}, year = {2015}, language = {en} } @article{FrotscherKochStaat2015, author = {Frotscher, Ralf and Koch, Jan-Peter and Staat, Manfred}, title = {Computational investigation of drug action on human-induced stem cell derived cardiomyocytes}, series = {Journal of biomechanical engineering}, volume = {Vol. 137}, journal = {Journal of biomechanical engineering}, number = {iss. 7}, publisher = {ASME}, address = {New York}, issn = {1528-8951 (E-Journal); 0148-0731 (Print)}, doi = {10.1115/1.4030173}, pages = {071002-1 -- 071002-7}, year = {2015}, language = {en} } @article{KotliarLanzl2002, author = {Kotliar, Konstantin and Lanzl, I. M.}, title = {Biomechanical modeling of the aqueous humor outflow after non-penetrating glaucoma filtration surgery in the human eye}, series = {Acta of bioengineering and biomechanics}, volume = {Vol. 4}, journal = {Acta of bioengineering and biomechanics}, number = {Suppl. 1}, issn = {1509-409X}, pages = {728 -- 729}, year = {2002}, language = {de} } @article{KotliarDrozdovaShamshinova2006, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment.
 Part I. Ocular blood circulation and its quantitative estimation}, series = {National journal Glaucoma}, volume = {Vol. 5}, journal = {National journal Glaucoma}, number = {No. 3}, issn = {2078-4104}, pages = {62 -- 73}, year = {2006}, language = {ru} } @article{KotliarDrozdovaShamshinova2006, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment. Part II. Invasive methods of assessment of ocular blood flow}, series = {National Journal Glaucoma}, volume = {Vol. 5}, journal = {National Journal Glaucoma}, number = {No. 4}, issn = {2078-4104}, pages = {37 -- 49}, year = {2006}, language = {ru} } @article{KotliarDrozdovaShamshinova2007, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 1. Assessment of blood cell velocities and flow rates in intraocular vessels and vascular beds}, series = {Journal of Glaucoma}, volume = {Vol. 6}, journal = {Journal of Glaucoma}, number = {1}, issn = {2078-4104}, pages = {61 -- 68}, year = {2007}, language = {ru} } @article{KotliarDrozdovaShamshinova2007, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 2. Static and dynamic assessment of retinal vessel reaction to stimuli}, series = {National Journal Glaucoma}, volume = {Vol. 6}, journal = {National Journal Glaucoma}, number = {No. 2}, issn = {2078-4104}, pages = {64 -- 71}, year = {2007}, language = {ru} } @article{KappmeyerKotliarLanzl2009, author = {Kappmeyer, K. and Kotliar, Konstantin and Lanzl, I. M.}, title = {Spielen von Blasinstrumenten und Augeninnendruck}, series = {Zeitschrift f{\"u}r praktische Augenheilkunde \& augen{\"a}rztliche Fortbildung : ZPA}, volume = {Bd. 30}, journal = {Zeitschrift f{\"u}r praktische Augenheilkunde \& augen{\"a}rztliche Fortbildung : ZPA}, issn = {1436-0322}, pages = {169 -- 171}, year = {2009}, language = {de} } @article{KotliarKharoubiSchmidtTrucksaessetal.2009, author = {Kotliar, Konstantin and Kharoubi, A. and Schmidt-Trucks{\"a}ß, A. and Halle, M. and Lanzl, I.}, title = {Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons?}, series = {Acta Ophthalmologica}, volume = {Vol. 87}, journal = {Acta Ophthalmologica}, number = {Suppl. S244}, publisher = {Wiley}, address = {Weinheim}, issn = {1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print)}, pages = {0}, year = {2009}, language = {en} } @phdthesis{Kotliar2013, author = {Kotliar, Konstantin}, title = {Dynamische retinale Gef{\"a}ßanalyse f{\"u}r die Diagnostik und Fr{\"u}herkennung von System- und Augenerkrankungen vaskul{\"a}rer Genese}, pages = {128 Bl.}, year = {2013}, language = {de} } @article{MartinGonzalezKotliarRiosMartinezetal.2014, author = {Martin-Gonzalez, Anabel and Kotliar, Konstantin and Rios-Martinez, Jorge and Lanzl, Ines and Navab, Nassir}, title = {Mediated-reality magnification for macular degeneration rehabilitation}, series = {Journal of Modern Optics}, volume = {61}, journal = {Journal of Modern Optics}, number = {17}, publisher = {Taylor \& Francis}, address = {London}, issn = {1362-3044}, doi = {10.1080/09500340.2014.936110}, pages = {1400 -- 1408}, year = {2014}, language = {en} } @article{SeifarthGossmannGrosseetal.2015, author = {Seifarth, Volker and Goßmann, Matthias and Grosse, J. O. and Becker, C. and Heschel, I. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds}, series = {Urologia Internationalis}, volume = {2015}, journal = {Urologia Internationalis}, number = {95}, publisher = {Karger}, address = {Basel}, issn = {0042-1138}, doi = {10.1159/000368419}, pages = {106 -- 113}, year = {2015}, language = {en} } @incollection{TranStaat2015, author = {Tran, Thanh Ngoc and Staat, Manfred}, title = {Uncertainty multimode failure and shakedown analysis of shells}, series = {Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ...}, booktitle = {Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ...}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-12927-3 (print) ; 978-3-319-12928-0 (online)}, doi = {10.1007/978-3-319-12928-0_14}, pages = {279 -- 298}, year = {2015}, abstract = {This paper presents a numerical procedure for reliability analysis of thin plates and shells with respect to plastic collapse or to inadaptation. The procedure involves a deterministic shakedown analysis for each probabilistic iteration, which is based on the upper bound approach and the use of the exact Ilyushin yield surface. Probabilistic shakedown analysis deals with uncertainties originated from the loads, material strength and thickness of the shell. Based on a direct definition of the limit state function, the calculation of the failure probability may be efficiently solved by using the First and Second Order Reliability Methods (FORM and SORM). The problem of reliability of structural systems (series systems) is handled by the application of a special technique which permits to find all the design points corresponding to all the failure modes. Studies show, in this case, that it improves considerably the FORM and SORM results.}, language = {en} } @article{DachwaldMikuckiTulaczyketal.2014, author = {Dachwald, Bernd and Mikucki, Jill and Tulaczyk, Slawek and Digel, Ilya and Espe, Clemens and Feldmann, Marco and Francke, Gero and Kowalski, Julia and Xu, Changsheng}, title = {IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems}, series = {Annals of Glaciology}, volume = {55}, journal = {Annals of Glaciology}, number = {65}, publisher = {Cambridge University Press}, address = {Cambridge}, issn = {1727-5644}, doi = {10.3189/2014AoG65A004}, pages = {14 -- 22}, year = {2014}, abstract = {There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample.}, language = {en} } @inproceedings{VoronkovaBauerKotliar2014, author = {Voronkova, Eva B. and Bauer, Svetlana M. and Kotliar, Konstantin}, title = {Computer simulation of the cornea-scleral shell as applied to pressure-volume relationship in the human eye}, series = {2014 International Conference on Computer Technologies in Physical and Engineering Applications : ICCTPEA 2014 : proceedings : June 30 2014-July 4 2014, St. Petersburg}, booktitle = {2014 International Conference on Computer Technologies in Physical and Engineering Applications : ICCTPEA 2014 : proceedings : June 30 2014-July 4 2014, St. Petersburg}, organization = {Institute of Electrical and Electronics Engineers}, isbn = {978-1-4799-5315-8}, pages = {204 -- 205}, year = {2014}, language = {en} } @article{KonstantinidisFloresMartinezDachwaldetal.2015, author = {Konstantinidis, Konstantinos and Flores Martinez, Claudio and Dachwald, Bernd and Ohndorf, Andreas and Dykta, Paul and Bowitz, Pascal and Rudolph, Martin and Digel, Ilya and Kowalski, Julia and Voigt, Konstantin and F{\"o}rstner, Roger}, title = {A lander mission to probe subglacial water on Saturn's moon enceladus for life}, series = {Acta astronautica}, volume = {Vol. 106}, journal = {Acta astronautica}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1879-2030 (E-Journal); 0094-5765 (Print)}, pages = {63 -- 89}, year = {2015}, language = {en} } @incollection{KnottSofroniaGerressenetal.2014, author = {Knott, Thomas C. and Sofronia, Raluca E. and Gerressen, Marcus and Law, Yuen and Davidescu, Arjana and Savii, George G. and Gatzweiler, Karl-Heinz and Staat, Manfred and Kuhlen, Torsten W.}, title = {Preliminary bone sawing model for a virtual reality-based training simulator of bilateral sagittal split osteotomy}, series = {Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789)}, booktitle = {Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789)}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-12057-7 (Online)}, doi = {10.1007/978-3-319-12057-7_1}, pages = {1 -- 10}, year = {2014}, abstract = {Successful bone sawing requires a high level of skill and experience, which could be gained by the use of Virtual Reality-based simulators. A key aspect of these medical simulators is realistic force feedback. The aim of this paper is to model the bone sawing process in order to develop a valid training simulator for the bilateral sagittal split osteotomy, the most often applied corrective surgery in case of a malposition of the mandible. Bone samples from a human cadaveric mandible were tested using a designed experimental system. Image processing and statistical analysis were used for the selection of four models for the bone sawing process. The results revealed a polynomial dependency between the material removal rate and the applied force. Differences between the three segments of the osteotomy line and between the cortical and cancellous bone were highlighted.}, language = {en} } @incollection{FrotscherGossmannRaatschenetal.2015, author = {Frotscher, Ralf and Goßmann, Matthias and Raatschen, Hans-J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Staat, Manfred}, title = {Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM}, series = {Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45)}, booktitle = {Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45)}, publisher = {Springer}, address = {Heidelberg}, isbn = {978-3-319-02534-6 ; 978-3-319-02535-3}, pages = {187 -- 212}, year = {2015}, abstract = {We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEM for plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments.}, language = {en} } @article{StadlerGarveyEmbsetal.2014, author = {Stadler, Alexander Maximilian and Garvey, Christopher J. and Embs, Jan Peter and Koza, Michael Marek and Unruh, Tobias and Artmann, Gerhard and Zaccai, Guiseppe}, title = {Picosecond dynamics in haemoglobin from different species: A quasielastic neutron scattering study}, series = {Biochimica et biophysica acta (BBA): General Subjects}, volume = {1840}, journal = {Biochimica et biophysica acta (BBA): General Subjects}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-8006 (E-Journal); 0304-4165 (Print)}, doi = {10.1016/j.bbagen.2014.06.007}, pages = {2989 -- 2999}, year = {2014}, language = {en} } @inproceedings{DachwaldFeldmannEspeetal.2012, author = {Dachwald, Bernd and Feldmann, Marco and Espe, Clemens and Plescher, Engelbert and Konstantinidis, K. and Forstner, R.}, title = {Enceladus explorer - A maneuverable subsurface probe for autonomous navigation through deep ice}, series = {63rd International Astronautical Congress 2012, IAC 2012; Naples; Italy; 1 October 2012 through 5 October 2012. (Proceedings of the International Astronautical Congress, IAC ; 3)}, booktitle = {63rd International Astronautical Congress 2012, IAC 2012; Naples; Italy; 1 October 2012 through 5 October 2012. (Proceedings of the International Astronautical Congress, IAC ; 3)}, publisher = {Curran}, address = {Red Hook, NY}, organization = {International Astronautical Congress <63, 2012, Napoli>}, isbn = {978-1-62276-979-7}, pages = {1756 -- 1766}, year = {2012}, language = {en} } @inproceedings{KonstantinidisDachwaldOhndorfetal.2013, author = {Konstantinidis, K. and Dachwald, Bernd and Ohndorf, A. and Dykta, P. and Voigt, K. and F{\"o}rstner, R.}, title = {Enceladus explorer (ENEX): A lander mission to probe subglacial water pockets on Saturn's moon enceladus for life}, series = {64th International Astronautical Congress 2013 (IAC 2013) : Beijing, China, 23 - 27 September 2013. (Proceedings of the International Astronautical Congress, IAC ; 2)}, booktitle = {64th International Astronautical Congress 2013 (IAC 2013) : Beijing, China, 23 - 27 September 2013. (Proceedings of the International Astronautical Congress, IAC ; 2)}, publisher = {Curran}, address = {Red Hook, NY}, organization = {International Astronautical Congress <64, 2013, Beijing>}, isbn = {978-1-62993-909-4}, pages = {1340 -- 1350}, year = {2013}, language = {en} } @article{FrotscherStaat2014, author = {Frotscher, Ralf and Staat, Manfred}, title = {Stresses produced by different textile mesh implants in a tissue equivalent}, series = {BioNanoMaterials}, volume = {15}, journal = {BioNanoMaterials}, number = {1-2}, publisher = {De Gruyter}, address = {Berlin}, issn = {2191-4672 (E-Journal); 2193-066X (E-Journal); 0011-8656 (Print); 1616-0177 (Print); 2193-0651 (Print)}, doi = {10.1515/bnm-2014-0003}, pages = {25 -- 30}, year = {2014}, abstract = {Two single-incision mini-slings used for treating urinary incontinence in women are compared with respect to the stresses they produce in their surrounding tissue. In an earlier paper we experimentally observed that these implants produce considerably different stress distributions in a muscle tissue equivalent. Here we perform 2D finite element analyses to compare the shear stresses and normal stresses in the tissue equivalent for the two meshes and to investigate their failure behavior. The results clearly show that the Gynecare TVT fails for increasing loads in a zipper-like manner because it gradually debonds from the surrounding tissue. Contrary to that, the tissue at the ends of the DynaMesh-SIS direct may rupture but only at higher loads. The simulation results are in good agreement with the experimental observations thus the computational model helps to interpret the experimental results and provides a tool for qualitative evaluation of mesh implants.}, language = {en} } @article{CiobanuStaatRahimi2008, author = {Ciobanu, Octavian and Staat, Manfred and Rahimi, Alireza}, title = {The use of open source software in biomechanical finite element analysis}, series = {Buletinul Institutului Politehnic din Ia{\c{s}}i / Universitatea Tehnică Gh. Asachi, Ia{\c{s}}i Secţia 5, Construcţii de ma{\c{s}}ini = Machine construction = Bulletin of the Polytechnic Institute of Jassy = Izvestija Jasskogo Politechničeskogo Instituta}, volume = {54}, journal = {Buletinul Institutului Politehnic din Ia{\c{s}}i / Universitatea Tehnică Gh. Asachi, Ia{\c{s}}i Secţia 5, Construcţii de ma{\c{s}}ini = Machine construction = Bulletin of the Polytechnic Institute of Jassy = Izvestija Jasskogo Politechničeskogo Instituta}, number = {7/8}, issn = {1011-2855}, pages = {213 -- 220}, year = {2008}, language = {en} } @article{MansurovJandosovKerimkulovaetal.2014, author = {Mansurov, Z. A. and Jandosov, J. M. and Kerimkulova, A. R. and Azat, S. and Zhubanova, A. A. and Digel, Ilya and Savistkaya, I. S. and Akimbekov, N. S. and Kistaubaeva, A. S.}, title = {Nanostructured carbon materials for biomedical use}, series = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences}, volume = {15 (2013)}, journal = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences}, number = {3}, publisher = {Institute of Combustion Problems}, address = {Almaty}, issn = {1562-3920}, doi = {10.18321/ectj224}, pages = {209 -- 217}, year = {2014}, abstract = {One of the priority trends of carbon nanotechnology is creation of nanocomposite systems. Such carbon nanostructured composites were produced using - raw materials based on the products of agricultural waste, such as grape stones, apricot stones, rice husk. These products have a - wide spectrum of application and can be obtained in large quantities. The Institute of Combustion Problems has carried out the work on synthesis of the nanostructured carbon sorbents for multiple applications including the field of biomedicine. The article presents the data on the synthesis and physico-chemical properties of carbonaceous sorbents using physicochemical methods of investigation: separation and purification of biomolecules; isolation of phytohormone - fusicoccin; adsorbent INGO-1 in the form of an adsorption column for blood detoxification, oral (entero) sorbent - INGO-2; the study of efferent and probiotic properties and sorption activity in regard to the lipopolysaccharide (LPS), new biocomposites - based on carbonized rice husk (CRH) and cellular microorganisms; the use of CRH in wound treatment. A new material for blood detoxication (INGO-1) has been obtained. Adsorption of p-cresyl sulfate and indoxyl sulfate has shown that active carbon adsorbent can remove clinically significant level of p-cresyl sulfate and indoxyl sulfate from human plasma. Enterosorbent INGO-2 possesses high adsorption activity in relation to Gram-negative bacteria and their endotoxins. INGO-2 slows down the growth of conditionally pathogenic microorganisms, without having a negative effect on bifido and lactobacteria. The use of enterosorbent INGO-2 for sorption therapy may provide a solution to a complex problem - detoxication of the digestive tract and normalization of the intestinal micro ecology. The immobilized probiotic called "Riso-lact" was registered at the Ministry of Health of the Republic of Kazakhstan as a biologically active food additive. The developed technology is patented and provides production of the medicine in the form of freeze-dried biomass immobilized in vials.}, language = {en} } @inproceedings{TranStaatStavroulakis2014, author = {Tran, Ngoc Trinh and Staat, Manfred and Stavroulakis, G. E.}, title = {A multicriteria method for truss optimization}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {1 -- 12}, year = {2014}, language = {en} } @inproceedings{DuongStaat2014, author = {Duong, Minh Tuan and Staat, Manfred}, title = {A face-based smoothed finite element method for hyperelastic models and tissue growth}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {1 -- 12}, year = {2014}, language = {en} } @inproceedings{TranStaat2014, author = {Tran, Thanh Ngoc and Staat, Manfred}, title = {Uncertain multimode failure and limit analysis of shells}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {1 -- 12}, year = {2014}, language = {en} } @inproceedings{BhattaraiFrotscherSoraetal.2014, author = {Bhattarai, Aroj and Frotscher, Ralf and Sora, M.-C. and Staat, Manfred}, title = {A 3D finite element model of the female pelvic floor for the reconstruction of urinary incontinence}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {1 -- 12}, year = {2014}, language = {en} } @inproceedings{JungStaatMueller2014, author = {Jung, Alexander and Staat, Manfred and M{\"u}ller, Wolfram}, title = {Optimization of the flight style in ski jumping}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {799 -- 810}, year = {2014}, language = {en} } @inproceedings{FrotscherKochRaatschenetal.2014, author = {Frotscher, Ralf and Koch, Jan-Peter and Raatschen, Hans-J{\"u}rgen and Staat, Manfred}, title = {Evaluation of a computational model for drug action on cardiac tissue}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {1 -- 12}, year = {2014}, language = {en} } @article{TuraliyevaYeshibaevDigeletal.2014, author = {Turaliyeva, M. and Yeshibaev, A. and Digel, Ilya and Elibayeva, G. and Sydykova, A. and Uspabayeva, A. and Dosybayeva, G. and Zhylysbayeva, A. and Lakhanova, K.}, title = {Molecular-genetic identification of emerged novel invasive pathogens of Asiatic Elm Ulmus pumila L}, series = {Life science journal}, volume = {11}, journal = {Life science journal}, number = {Spec. iss. 5s}, publisher = {Marsland Press}, address = {New York}, issn = {1097-8135}, doi = {10.7537/marslsj1105s14.33}, pages = {171 -- 175}, year = {2014}, abstract = {The dwarf elm Ulmus pumila L. (Ulmaceae) is one of indigenous species of flora in Kazakhstan and forms a basis of dendroflora in virtually all settlements of the region. In the past decade, multiple outbreaks of previously unknown diseases of the small-leaved elm have been registered. In our study, by the molecular-genetic analysis it was found that the pathogens responsible for the outbreaks are microfungi belonging to the genus Fusarium - F. solani and F. oxysporum. The nucleotide sequences (ITS regions) isolated from the diseased trees showed very high similarity with the GenBank control numbers EU625403.1 and FJ478128.1 (100.0 and 99.0 \% respectively). Oncoming research will focus on the search of natural microbial antagonists of the discovered phytopathogens.}, language = {en} } @article{FuestKotliarWalteretal.2014, author = {Fuest, Matthias and Kotliar, Konstantin and Walter, Peter and Plange, Niklas}, title = {Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry}, series = {Ophthalmic and physiological optics}, volume = {34}, journal = {Ophthalmic and physiological optics}, number = {4}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1475-1313 (E-Journal); 0275-5408 (Print)}, doi = {10.1111/opo.12134}, pages = {438 -- 444}, year = {2014}, language = {en} }