@incollection{StengerAltherrMuelleretal.2018, author = {Stenger, David and Altherr, Lena and M{\"u}ller, Tankred and Pelz, Peter F.}, title = {Product family design optimization using model-based engineering techniques}, series = {Operations Research Proceedings 2017}, booktitle = {Operations Research Proceedings 2017}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-89919-0}, doi = {10.1007/978-3-319-89920-6_66}, pages = {495 -- 502}, year = {2018}, abstract = {Highly competitive markets paired with tremendous production volumes demand particularly cost efficient products. The usage of common parts and modules across product families can potentially reduce production costs. Yet, increasing commonality typically results in overdesign of individual products. Multi domain virtual prototyping enables designers to evaluate costs and technical feasibility of different single product designs at reasonable computational effort in early design phases. However, savings by platform commonality are hard to quantify and require detailed knowledge of e.g. the production process and the supply chain. Therefore, we present and evaluate a multi-objective metamodel-based optimization algorithm which enables designers to explore the trade-off between high commonality and cost optimal design of single products.}, language = {en} } @inproceedings{LeiseAltherr2018, author = {Leise, Philipp and Altherr, Lena}, title = {Optimizing the design and control of decentralized water supply systems - a case-study of a hotel building}, series = {EngOpt 2018 Proceedings of the 6th International Conference on Engineering Optimization}, booktitle = {EngOpt 2018 Proceedings of the 6th International Conference on Engineering Optimization}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-97773-7}, doi = {10.1007/978-3-319-97773-7_107}, pages = {1241 -- 1252}, year = {2018}, abstract = {To increase pressure to supply all floors of high buildings with water, booster stations, normally consisting of several parallel pumps in the basement, are used. In this work, we demonstrate the potential of a decentralized pump topology regarding energy savings in water supply systems of skyscrapers. We present an approach, based on Mixed-Integer Nonlinear Programming, that allows to choose an optimal network topology and optimal pumps from a predefined construction kit comprising different pump types. Using domain-specific scaling laws and Latin Hypercube Sampling, we generate different input sets of pump types and compare their impact on the efficiency and cost of the total system design. As a realistic application example, we consider a hotel building with 325 rooms, 12 floors and up to four pressure zones.}, language = {en} } @article{SunAltherrPeietal.2018, author = {Sun, Hui and Altherr, Lena and Pei, Ji and Pelz, Peter F. and Yuan, Shouqi}, title = {Optimal booster station design and operation under uncertain load}, series = {Applied Mechanics and Materials}, volume = {885}, journal = {Applied Mechanics and Materials}, publisher = {Trans Tech Publications}, address = {B{\"a}ch}, issn = {1662-7482}, doi = {10.4028/www.scientific.net/AMM.885.102}, pages = {102 -- 115}, year = {2018}, abstract = {Given industrial applications, the costs for the operation and maintenance of a pump system typically far exceed its purchase price. For finding an optimal pump configuration which minimizes not only investment, but life-cycle costs, methods like Technical Operations Research which is based on Mixed-Integer Programming can be applied. However, during the planning phase, the designer is often faced with uncertain input data, e.g. future load demands can only be estimated. In this work, we deal with this uncertainty by developing a chance-constrained two-stage (CCTS) stochastic program. The design and operation of a booster station working under uncertain load demand are optimized to minimize total cost including purchase price, operation cost incurred by energy consumption and penalty cost resulting from water shortage. We find optimized system layouts using a sample average approximation (SAA) algorithm, and analyze the results for different risk levels of water shortage. By adjusting the risk level, the costs and performance range of the system can be balanced, and thus the system's resilience can be engineered}, language = {en} } @article{AltherrJoggerstLeiseetal.2018, author = {Altherr, Lena and Joggerst, Laura and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas and Wendt, Janine}, title = {On obligations in the development process of resilient systems with algorithmic design methods}, series = {Applied Mechanics and Materials}, volume = {885}, journal = {Applied Mechanics and Materials}, number = {885}, publisher = {Trans Tech Publications}, address = {B{\"a}ch}, isbn = {1662-7482}, doi = {10.4028/www.scientific.net/AMM.885.240}, pages = {240 -- 252}, year = {2018}, abstract = {Advanced computational methods are needed both for the design of large systems and to compute high accuracy solutions. Such methods are efficient in computation, but the validation of results is very complex, and highly skilled auditors are needed to verify them. We investigate legal questions concerning obligations in the development phase, especially for technical systems developed using advanced methods. In particular, we consider methods of resilient and robust optimization. With these techniques, high performance solutions can be found, despite a high variety of input parameters. However, given the novelty of these methods, it is uncertain whether legal obligations are being met. The aim of this paper is to discuss if and how the choice of a specific computational method affects the developer's product liability. The review of legal obligations in this paper is based on German law and focuses on the requirements that must be met during the design and development process.}, language = {en} } @article{RauschFriesenAltherretal.2018, author = {Rausch, Lea and Friesen, John and Altherr, Lena and Meck, Marvin and Pelz, Peter F.}, title = {A holistic concept to design optimal water supply infrastructures for informal settlements using remote sensing data}, series = {Remote Sensing}, volume = {10}, journal = {Remote Sensing}, number = {2}, publisher = {MDPI}, address = {Basel}, isbn = {2072-4292}, doi = {10.3390/rs10020216}, pages = {1 -- 23}, year = {2018}, abstract = {Ensuring access to water and sanitation for all is Goal No. 6 of the 17 UN Sustainability Development Goals to transform our world. As one step towards this goal, we present an approach that leverages remote sensing data to plan optimal water supply networks for informal urban settlements. The concept focuses on slums within large urban areas, which are often characterized by a lack of an appropriate water supply. We apply methods of mathematical optimization aiming to find a network describing the optimal supply infrastructure. Hereby, we choose between different decentral and central approaches combining supply by motorized vehicles with supply by pipe systems. For the purposes of illustration, we apply the approach to two small slum clusters in Dhaka and Dar es Salaam. We show our optimization results, which represent the lowest cost water supply systems possible. Additionally, we compare the optimal solutions of the two clusters (also for varying input parameters, such as population densities and slum size development over time) and describe how the result of the optimization depends on the entered remote sensing data.}, language = {en} } @incollection{MuellerAltherrAholaetal.2018, author = {M{\"u}ller, Tim M. and Altherr, Lena and Ahola, Marja and Schabel, Samuel and Pelz, Peter F.}, title = {Optimizing pressure screen systems in paper recycling: optimal system layout, component selection and operation}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-18499-5}, doi = {10.1007/978-3-030-18500-8_44}, pages = {355 -- 361}, year = {2018}, abstract = {Around 60\% of the paper worldwide is made from recovered paper. Especially adhesive contaminants, so called stickies, reduce paper quality. To remove stickies but at the same time keep as many valuable fibers as possible, multi-stage screening systems with several interconnected pressure screens are used. When planning such systems, suitable screens have to be selected and their interconnection as well as operational parameters have to be defined considering multiple conflicting objectives. In this contribution, we present a Mixed-Integer Nonlinear Program to optimize system layout, component selection and operation to find a suitable trade-off between output quality and yield.}, language = {en} } @article{AltherrLeisePfetschetal.2018, author = {Altherr, Lena and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas}, title = {Algorithmic design and resilience assessment of energy efficient high-rise water supply systems}, series = {Applied Mechanics and Materials}, volume = {885}, journal = {Applied Mechanics and Materials}, publisher = {Trans Tech Publications}, address = {B{\"a}ch}, issn = {1662-7482}, doi = {10.4028/www.scientific.net/AMM.885.211}, pages = {211 -- 223}, year = {2018}, abstract = {High-rise water supply systems provide water flow and suitable pressure in all levels of tall buildings. To design such state-of-the-art systems, the consideration of energy efficiency and the anticipation of component failures are mandatory. In this paper, we use Mixed-Integer Nonlinear Programming to compute an optimal placement of pipes and pumps, as well as an optimal control strategy.Moreover, we consider the resilience of the system to pump failures. A resilient system is able to fulfill a predefined minimum functionality even though components fail or are restricted in their normal usage. We present models to measure and optimize the resilience. To demonstrate our approach, we design and analyze an optimal resilient decentralized water supply system inspired by a real-life hotel building.}, language = {en} } @inproceedings{MarinkovicButenweg2018, author = {Marinkovic, Marko and Butenweg, Christoph}, title = {Innovative System for Earthquake Resistant Masonry Infill Walls}, series = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, booktitle = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, pages = {1 -- 12}, year = {2018}, language = {en} } @inproceedings{ButenwegMarinkovicFehlingetal.2018, author = {Butenweg, Christoph and Marinkovic, Marko and Fehling, Ekkehard and Pfetzing, Thomas and Kubalski, Thomas}, title = {Experimental and Numerical Investigations of Reinforced Concrete Frames with Masonry Infills under Combined In- and Out-of-plane Seismic Loading}, series = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, booktitle = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, pages = {1 -- 12}, year = {2018}, language = {en} } @inproceedings{MichelButenwegKlinkel2018, author = {Michel, Philipp and Butenweg, Christoph and Klinkel, Sven}, title = {Frequency Dependent Impedance Analysis of the Foundation-Soil-Systems of Onshore Wind Turbines}, series = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, booktitle = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, pages = {1 -- 13}, year = {2018}, language = {en} } @inproceedings{SchmittRosinButenweg2018, author = {Schmitt, Timo and Rosin, Julia and Butenweg, Christoph}, title = {Seismic Impact And Design Of Buried Pipelines}, series = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, booktitle = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, pages = {1 -- 12}, year = {2018}, abstract = {Seismic design of buried pipeline systems for energy and water supply is not only important for plant and operational safety but also for the maintenance of the supply infrastructure after an earthquake. The present paper shows special issues of the seismic wave impacts on buried pipelines, describes calculation methods, proposes approaches and gives calculation examples. This paper regards the effects of transient displacement differences and resulting tensions within the pipeline due to the wave propagation of the earthquake. However, the presented model can also be used to calculate fault rupture induced displacements. Based on a three-dimensional Finite Element Model parameter studies are performed to show the influence of several parameters such as incoming wave angle, wave velocity, backfill height and synthetic displacement time histories. The interaction between the pipeline and the surrounding soil is modeled with non-linear soil springs and the propagating wave is simulated affecting the pipeline punctually, independently in time and space. Special attention is given to long-distance heat pipeline systems. Here, in regular distances expansion bends are arranged to ensure movements of the pipeline due to high temperature. Such expansion bends are usually designed with small bending radii, which during the earthquake lead to high bending stresses in the cross-section of the pipeline. Finally, an interpretation of the results and recommendations are given for the most critical parameters.}, language = {en} } @inproceedings{MilkovaRosinButenwegetal.2018, author = {Milkova, Kristina and Rosin, Julia and Butenweg, Christoph and Dumova-Jovanoska, Elena}, title = {Development of Seismic Vulnerability Curves for Region Specific Masonry Buildings}, series = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, booktitle = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, pages = {1 -- 10}, year = {2018}, language = {en} } @inproceedings{AnicPenavaGuljasetal.2018, author = {Anic, Filip and Penava, Davorin and Guljas, Ivica and Sarhosis, Vasilis and Abrahamczyk, Lars and Butenweg, Christoph}, title = {The Effect of Openings on Out-of-Plane Capacity of Masonry Infilled Reinforced Concrete Frames}, series = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, booktitle = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, pages = {1 -- 11}, year = {2018}, language = {en} } @inproceedings{RosinButenwegBoesenetal.2018, author = {Rosin, Julia and Butenweg, Christoph and Boesen, Niklas and Gellert, Christoph}, title = {Evaluation of the Seismic Behavior of a Modern URM Building During the 2012 Northern Italy Earthquakes}, series = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, booktitle = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, pages = {1 -- 12}, year = {2018}, language = {en} } @inproceedings{ButenwegMarinkovic2018, author = {Butenweg, Christoph and Marinkovic, Marko}, title = {Damage reduction system for masonry infill walls under seismic loading}, series = {ce/papers}, volume = {2}, booktitle = {ce/papers}, number = {4}, publisher = {Ernst \& Sohn Verlag}, address = {Berlin}, doi = {10.1002/cepa.863}, pages = {267 -- 273}, year = {2018}, abstract = {Reinforced concrete (RC) frames with masonry infills are frequently used in seismic regions all over the world. Generally masonry infills are considered as nonstructural elements and thus are typically neglected in the design process. However, the observations made after strong earthquakes have shown that masonry infills can modify the dynamic behavior of the structure significantly. The consequences were total collapses of buildings and loss of human lives. This paper presents the new system INODIS (Innovative Decoupled Infill System) developed within the European research project INSYSME (Innovative Systems for Earthquake Resistant Masonry Enclosures in RC Buildings). INODIS decouples the frame and the masonry infill by means of special U-shaped rubbers placed in between frame and infill. The effectiveness of the system was investigated by means of full scale tests on RC frames with masonry infills subjected to in-plane and out-of-plane loading. Furthermore small specimen tests were conducted to determine material characteristics of the components and the resistances of the connections. Finally, a micromodel was developed to simulate the in-plane behavior of RC frames infilled with AAC blocks with and without installation of the INODIS system.}, language = {en} } @article{RosinButenwegCacciatoreetal.2018, author = {Rosin, Julia and Butenweg, Christoph and Cacciatore, Pamela and Boesen, Niklas}, title = {Investigation of the seismic performance of modern masonry buildings during the Emilia Romagna earthquake series}, series = {Mauerwerk}, volume = {22}, journal = {Mauerwerk}, number = {4}, publisher = {Ernst \& Sohn}, address = {Berlin}, issn = {1437-1022}, doi = {10.1002/dama.201800013}, pages = {238 -- 250}, year = {2018}, abstract = {The article presents the investigation of the seismic behaviour of a modern URM building located in the municipality of Finale Emilia in province of Modena, Northern Italy. The building is situated in the centre of the series of the 2012 Northern Italy earthquakes and has not suffered any damage during the earthquake series in 2012. The observed earthquake resistance of the building is compared with predicted resistances based on linear and nonlinear design approaches according to Eurocode. Furthermore, probabilistic analyses based on nonlinear calculation models taking into account scattering of the most relevant input parameters are carried out to identify their influence to the results and to derive fragility curves.}, language = {en} } @article{MichelButenwegKinkel2018, author = {Michel, Philipp and Butenweg, Christoph and Kinkel, Sven}, title = {Pile-grid foundations of onshore wind turbines considering soil-structure-interaction under seismic loading}, series = {Soil Dynamics and Earthquake Engineering}, volume = {109}, journal = {Soil Dynamics and Earthquake Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0267-7261}, doi = {10.1016/j.soildyn.2018.03.009}, pages = {299 -- 311}, year = {2018}, abstract = {In recent years, many onshore wind turbines are erected in seismic active regions and on soils with poor load bearing capacity, where pile grids are inevitable to transfer the loads into the ground. In this contribution, a realistic multi pile grid is designed to analyze the dynamics of a wind turbine tower including frequency dependent soil-structure-interaction. It turns out that different foundations on varying soil configurations heavily influence the vibration response. While the vibration amplitude is mostly attenuated, certain unfavorable combinations of structure and soil parameters lead to amplification in the range of the system's natural frequencies. This testifies the need for overall dynamic analysis in the assessment of the dynamic stability and the holistic frequency tuning of the turbines.}, language = {en} } @article{ConzenAlbannaWeissetal.2018, author = {Conzen, Catharina and Albanna, Walid and Weiss, Miriam and K{\"u}rten, David and Vilser, Walthard and Kotliar, Konstantin and Z{\"a}ske, Charlotte and Clusmann, Hans and Schubert, Gerrit Alexander}, title = {Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes}, series = {Translational Stroke Research}, journal = {Translational Stroke Research}, number = {9}, publisher = {Springer Nature}, address = {Cham}, issn = {1868-601X}, doi = {10.1007/s12975-017-0585-8}, pages = {284 -- 293}, year = {2018}, abstract = {Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5-14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome.}, language = {en} } @article{SvaneborgKarimiVarzanehHojdisetal.2018, author = {Svaneborg, Carsten and Karimi-Varzaneh, Hossein Ali and Hojdis, Nils and Fleck, Franz and Everaers, Ralf}, title = {Kremer-Grest Models for Universal Properties of Specific Common Polymer Species}, series = {Soft Condensed Matter}, journal = {Soft Condensed Matter}, number = {1606.05008}, year = {2018}, abstract = {The Kremer-Grest (KG) bead-spring model is a near standard in Molecular Dynamic simulations of generic polymer properties. It owes its popularity to its computational efficiency, rather than its ability to represent specific polymer species and conditions. Here we investigate how to adapt the model to match the universal properties of a wide range of chemical polymers species. For this purpose we vary a single parameter originally introduced by Faller and M{\"u}ller-Plathe, the chain stiffness. Examples include polystyrene, polyethylene, polypropylene, cis-polyisoprene, polydimethylsiloxane, polyethyleneoxide and styrene-butadiene rubber. We do this by matching the number of Kuhn segments per chain and the number of Kuhn segments per cubic Kuhn volume for the polymer species and for the Kremer-Grest model. We also derive mapping relations for converting KG model units back to physical units, in particular we obtain the entanglement time for the KG model as function of stiffness allowing for a time mapping. To test these relations, we generate large equilibrated well entangled polymer melts, and measure the entanglement moduli using a static primitive-path analysis of the entangled melt structure as well as by simulations of step-strain deformation of the model melts. The obtained moduli for our model polymer melts are in good agreement with the experimentally expected moduli.}, language = {en} } @inproceedings{JockwerKleiberUibel2018, author = {Jockwer, R. and Kleiber, M. and Uibel, Thomas}, title = {Criteria for Evaluating the Simplification of Design Rules for Dowel-type Fasteners}, series = {International Network on Timber Engineering Research, INTER : proceedings, meeting 51, 10 - 13 August 2016, Tallinn, Estonia}, booktitle = {International Network on Timber Engineering Research, INTER : proceedings, meeting 51, 10 - 13 August 2016, Tallinn, Estonia}, editor = {G{\"o}rlacher, Rainer}, publisher = {Timber Scientific Publishing, KIT Holzbau und Baukonstruktionen}, address = {Karlsruhe}, pages = {461 -- 466}, year = {2018}, language = {en} } @article{OttenWeberArent2018, author = {Otten, Dennis and Weber, Tobias and Arent, Jan-Christoph}, title = {Manufacturing Process Simulation - On Its Way to Industrial Application}, series = {International Journal of Aviation, Aeronautics, and Aerospace}, volume = {5}, journal = {International Journal of Aviation, Aeronautics, and Aerospace}, number = {2}, publisher = {Embry-Riddle Aeronautical University}, address = {Daytona Beach, Fla.}, issn = {2374-6793}, doi = {10.15394/ijaaa.2018.1217}, year = {2018}, abstract = {Manufacturing process simulation (MPS) has become more and more important for aviation and the automobile industry. A highly competitive market requires the use of high performance metals and composite materials in combination with reduced manufacturing cost and time as well as a minimization of the time to market for a new product. However, the use of such materials is expensive and requires sophisticated manufacturing processes. An experience based process and tooling design followed by a lengthy trial-and-error optimization is just not contemporary anymore. Instead, a tooling design process aided by simulation is used more often. This paper provides an overview of the capabilities of MPS in the fields of sheet metal forming and prepreg autoclave manufacturing of composite parts summarizing the resulting benefits for tooling design and manufacturing engineering. The simulation technology is explained briefly in order to show several simplification and optimization techniques for developing industrialized simulation approaches. Small case studies provide examples of an efficient application on an industrial scale.}, language = {en} } @article{EdipSesovButenwegetal.2018, author = {Edip, K. and Sesov, V. and Butenweg, Christoph and Bojadjieva, J.}, title = {Development of coupled numerical model for simulation of multiphase soil}, series = {Computers and Geotechnics}, volume = {96}, journal = {Computers and Geotechnics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0266-352X}, doi = {10.1016/j.compgeo.2017.08.016}, pages = {118 -- 131}, year = {2018}, abstract = {In this paper, a coupled multiphase model considering both non-linearities of water retention curves and solid state modeling is proposed. The solid displacements and the pressures of both water and air phases are unknowns of the proposed model. The finite element method is used to solve the governing differential equations. The proposed method is demonstrated through simulation of seepage test and partially consolidation problem. Then, implementation of the model is done by using hypoplasticity for the solid phase and analyzing the fully saturated triaxial experiments. In integration of the constitutive law error controlling is improved and comparisons done accordingly. In this work, the advantages and limitations of the numerical model are discussed.}, language = {en} } @article{EngelmannBuhlDraacketal.2018, author = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Draack, Sebastian and Viereck, Thilo and Frank, and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications}, series = {IEEE Magnetic Letters}, volume = {9}, journal = {IEEE Magnetic Letters}, number = {Article number 8519617}, publisher = {IEEE}, address = {New York, NY}, issn = {1949-307X}, doi = {10.1109/LMAG.2018.2879034}, year = {2018}, abstract = {Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23\% for agglomerated MNP in suspension and a decrease by up to 28\% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.}, language = {en} } @article{EngelmannRoethEberbecketal.2018, author = {Engelmann, Ulrich M. and Roeth, Anjali A.J. and Eberbeck, Dietmar and Buhl, Eva Miriam and Neumann, Ulf Peter and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells}, series = {Scientific Reports}, volume = {8}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, address = {Cham}, issn = {2045-2322}, doi = {10.1038/s41598-018-31553-9}, pages = {Article number 13210}, year = {2018}, abstract = {Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95\% was achieved by depositing an intracellular total thermal energy with about 50\% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86\% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65\% after MNP were internalized inside cells.}, language = {en} } @article{DigelWehlitzKayseretal.2018, author = {Digel, Ilya and Wehlitz, V. and Kayser, Peter and Figiel-Lange, A. and Bassam, R. and Rundstedt, F. von}, title = {Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids}, series = {Plant Pathology}, volume = {67}, journal = {Plant Pathology}, number = {2}, publisher = {Wiley}, address = {Oxford}, issn = {1365-3059}, doi = {10.1111/ppa.12750}, pages = {358 -- 365}, year = {2018}, abstract = {Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel 'suspension depletion' approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10-12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach.}, language = {en} } @phdthesis{Bhattarai2018, author = {Bhattarai, Aroj}, title = {Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants}, isbn = {978-3-9818074-8-6}, doi = {10.17185/duepublico/70340}, pages = {192 S.}, year = {2018}, language = {en} } @inproceedings{KromeSander2018, author = {Krome, Cornelia and Sander, Volker}, title = {Time series analysis with apache spark and its applications to energy informatics}, series = {Proceedings of the 7th DACH+ Conference on Energy Informatics}, booktitle = {Proceedings of the 7th DACH+ Conference on Energy Informatics}, doi = {10.1186/s42162-018-0043-1}, year = {2018}, abstract = {In energy economy forecasts of different time series are rudimentary. In this study, a prediction for the German day-ahead spot market is created with Apache Spark and R. It is just an example for many different applications in virtual power plant environments. Other examples of use as intraday price processes, load processes of machines or electric vehicles, real time energy loads of photovoltaic systems and many more time series need to be analysed and predicted. This work gives a short introduction into the project where this study is settled. It describes the time series methods that are used in energy industry for forecasts shortly. As programming technique Apache Spark, which is a strong cluster computing technology, is utilised. Today, single time series can be predicted. The focus of this work is on developing a method to parallel forecasting, to process multiple time series simultaneously with R and Apache Spark.}, language = {en} } @inproceedings{BlankeDringVonteinetal.2018, author = {Blanke, Tobias and Dring, Bernd and Vontein, Marius and Kuhnhenne, Markus}, title = {Climate Change Mitigation Potentials of Vertical Building Integrated Photovoltaic}, series = {8th International Workshop on Integration of Solar Power into Power Systems : 16-17 October 2018, Stockholm, Sweden}, booktitle = {8th International Workshop on Integration of Solar Power into Power Systems : 16-17 October 2018, Stockholm, Sweden}, pages = {1 -- 7}, year = {2018}, language = {en} } @article{HofmannLimpertMatareetal.2018, author = {Hofmann, Till and Limpert, Nicolas and Matar{\´e}, Victor and Sch{\"o}nitz, Sebastian and Niemueller, Tim and Ferrein, Alexander and Lakemeyer, Gerhard}, title = {The Carologistics RoboCup Logistics Team 2018}, year = {2018}, abstract = {The Carologistics team participates in the RoboCup Logistics League for the seventh year. The RCLL requires precise vision, manipulation and path planning, as well as complex high-level decision making and multi-robot coordination. We outline our approach with an emphasis on recent modifications to those components. The team members in 2018 are David Bosen, Christoph Gollok, Mostafa Gomaa, Daniel Habering, Till Hofmann, Nicolas Limpert, Sebastian Sch{\"o}nitz, Morian Sonnet, Carsten Stoffels, and Tarik Viehmann. This paper is based on the last year's team description.}, language = {en} } @article{MatchaLjubasGueldemet2018, author = {Matcha, Heike and Ljubas, Ante and Gueldemet, Harun}, title = {Printing a Coffee Bar: An investigation into mid-scale 3D printing}, series = {Computing for a better tomorrow - Proceedings of the 36th eCAADe Conference - Volume 2, Lodz University of Technology, Lodz, Poland, 19-21 September 2018}, journal = {Computing for a better tomorrow - Proceedings of the 36th eCAADe Conference - Volume 2, Lodz University of Technology, Lodz, Poland, 19-21 September 2018}, editor = {Kepczynska-Walczak, A.}, pages = {59 -- 68}, year = {2018}, abstract = {We present and discuss an exploration of the possibilities and properties of 3D printing with a printing space of 1 cubic meter, and how those can be integrated into architectural education through an experimental design and research course with students of architecture.We expand on issues presented at the eCAADe conference 2017 in Rome [Ref 6] by increasing the complexity and size of our prints, printing not a model to scale, but a full scale funtional prototype of a usable architectural object: A coffee bar.}, language = {en} } @article{KoenigWolf2018, author = {K{\"o}nig, Johannes Alexander and Wolf, Martin}, title = {GHOST: An Evaluated Competence Developing Game for Cybersecurity Awareness Training}, series = {International Journal on Advances in Security}, volume = {11}, journal = {International Journal on Advances in Security}, number = {3 \& 4}, publisher = {IARIA Journals}, issn = {1942-2636}, pages = {274 -- 287}, year = {2018}, abstract = {To train end users how to interact with digital systems is indispensable to ensure a strong computer security. 'Competence Developing Game'-based approaches are particularly suitable for this purpose because of their motivation-and simulation-aspects. In this paper the Competence Developing Game 'GHOST' for cybersecurity awareness trainings and its underlying patterns are described. Accordingly, requirements for an 'Competence Developing Game' based training are discussed. Based on these requirements it is shown how a game can fulfill these requirements. A supplementary game interaction design and a corresponding evaluation study is shown. The combination of training requirements and interaction design is used to create a 'Competence Developing Game'-based training concept. A part of these concept is implemented into a playable prototype that serves around one hour of play respectively training time. This prototype is used to perform an evaluation of the game and training aspects of the awareness training. Thereby, the quality of the game aspect and the effectiveness of the training aspect are shown.}, language = {en} } @inproceedings{BosseDeClercqBarnat2018, author = {Bosse, Elke and De Clercq, Mikael and Barnat, Miriam}, title = {The Role of Diversity for the Transition to Higher Education}, series = {EARLI SIG 4, Giessen}, booktitle = {EARLI SIG 4, Giessen}, pages = {13 Folien}, year = {2018}, language = {en} } @incollection{SchoeningWagnerPoghossianetal.2018, author = {Sch{\"o}ning, Michael Josef and Wagner, Torsten and Poghossian, Arshak and Miyamoto, K.I. and Werner, C.F. and Krause, S. and Yoshinobu, T.}, title = {Light-addressable potentiometric sensors for (bio-)chemical sensing and imaging}, series = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7}, booktitle = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {9780128097397}, pages = {295 -- 308}, year = {2018}, language = {en} } @inproceedings{WaldmannVeraDachwaldetal.2018, author = {Waldmann, Christoph and Vera, Jean-Pierre de and Dachwald, Bernd and Strasdeit, Henry and Sohl, Frank and Hanff, Hendrik and Kowalski, Julia and Heinen, Dirk and Macht, Sabine and Bestmann, Ulf and Meckel, Sebastian and Hildebrandt, Marc and Funke, Oliver and Gehrt, Jan-J{\"o}ran}, title = {Search for life in ice-covered oceans and lakes beyond Earth}, series = {2018 IEEE/OES Autonomous Underwater Vehicle Workshop, Proceedings November 2018, Article number 8729761}, booktitle = {2018 IEEE/OES Autonomous Underwater Vehicle Workshop, Proceedings November 2018, Article number 8729761}, doi = {10.1109/AUV.2018.8729761}, year = {2018}, abstract = {The quest for life on other planets is closely connected with the search for water in liquid state. Recent discoveries of deep oceans on icy moons like Europa and Enceladus have spurred an intensive discussion about how these waters can be accessed. The challenge of this endeavor lies in the unforeseeable requirements on instrumental characteristics both with respect to the scientific and technical methods. The TRIPLE/nanoAUV initiative is aiming at developing a mission concept for exploring exo-oceans and demonstrating the achievements in an earth-analogue context, exploring the ocean under the ice shield of Antarctica and lakes like Dome-C on the Antarctic continent.}, language = {en} } @inproceedings{GorzalkaDahlkeGoettscheetal.2018, author = {Gorzalka, Philip and Dahlke, Dennis and G{\"o}ttsche, Joachim and Israel, Martin and Patel, Dhruvkumar and Prahl, Christoph and Schmiedt, Jacob Estevam and Frommholz, Dirk and Hoffschmidt, Bernhard and Linkiewicz, Magdalena}, title = {Building Tomograph-From Remote Sensing Data of Existing Buildings to Building Energy Simulation Input}, series = {EBC, Annex 71, Fifth expert meeting, October 17-19, 2018, Innsbruck, Austria}, booktitle = {EBC, Annex 71, Fifth expert meeting, October 17-19, 2018, Innsbruck, Austria}, pages = {17 Seiten}, year = {2018}, language = {en} } @inproceedings{BirklDiendorferKernetal.2018, author = {Birkl, Josef and Diendorfer, Gerhard and Kern, Alexander and Thern, Stephan}, title = {Extremely high lightning peak currents}, series = {34th International Conference on Ligntning Protection, 02-07 September 2018}, booktitle = {34th International Conference on Ligntning Protection, 02-07 September 2018}, isbn = {978-1-5386-6635-7}, pages = {7 Seiten}, year = {2018}, language = {en} } @article{PuppeGiulianoFrantzetal.2018, author = {Puppe, Michael and Giuliano, Stefano and Frantz, Cathy and Uhlig, Ralf and Schumacher, Ralph and Ibraheem, Wagdi and Schmalz, Stefan and Waldmann, Barbara and Guder, Christoph and Peter, Dennis and Schwager, Christian and Teixeira Boura, Cristiano Jos{\´e} and Alexopoulos, Spiros and Spiegel, Michael and Wortmann, J{\"u}rgen and Hinrichs, Matthias and Engelhard, Manfred and Aust, Michael}, title = {Techno-economic optimization of molten salt solar tower plants}, series = {AIP Conference Proceedings art.no. 040033}, volume = {2033}, journal = {AIP Conference Proceedings art.no. 040033}, number = {Issue 1}, publisher = {AIP Publishing}, address = {Melville, NY}, doi = {10.1063/1.5067069}, year = {2018}, abstract = {In this paper the results of a techno-economic analysis of improved and optimized molten salt solar tower plants (MSSTP plants) are presented. The potential improvements that were analyzed include different receiver designs, different designs of the HTF-system and plant control, increased molten salt temperatures (up to 640°C) and multi-tower systems. Detailed technological and economic models of the solar field, solar receiver and high temperature fluid system (HTF-system) were developed and used to find potential improvements compared to a reference plant based on Solar Two technology and up-to-date cost estimations. The annual yield model calculates the annual outputs and the LCOE of all variants. An improved external tubular receiver and improved HTF-system achieves a significant decrease of LCOE compared to the reference. This is caused by lower receiver cost as well as improvements of the HTF-system and plant operation strategy, significantly reducing the plant own consumption. A novel star receiver shows potential for further cost decrease. The cavity receiver concepts result in higher LCOE due to their high investment cost, despite achieving higher efficiencies. Increased molten salt temperatures seem possible with an adapted, closed loop HTF-system and achieve comparable results to the original improved system (with 565°C) under the given boundary conditions. In this analysis all multi tower systems show lower economic viability compared to single tower systems, caused by high additional cost for piping connections and higher cost of the receivers. REFERENCES}, language = {en} } @inproceedings{GrundmannBauerBorchersetal.2018, author = {Grundmann, Jan Thimo and Bauer, Waldemar and Borchers, Kai and Dumont, Etienne and Grimm, Christian D. and Ho, Tra-Mi and Jahnke, Rico and Lange, Caroline and Maiwald, Volker and Mikulz, Eugen and Quantius, Dominik and Reershemius, Siebo and Renger, Thomas and Riemann, Johannes and Sasaki, Kaname and Seefeldt, Patric and Spietz, Peter and Spr{\"o}witz, Tom and Toth, Norbert and Wejmo, Elisabet and Biele, Jens and Krause, Christian and Cerotti, Matteo and Peloni, Alessandro and Dachwald, Bernd}, title = {Small Spacecraft Solar Sailing for Small Solar System Body Multiple Rendezvous and Landing}, series = {2018 IEEE Aerospace Conference : 3-10 March 2018}, booktitle = {2018 IEEE Aerospace Conference : 3-10 March 2018}, isbn = {978-1-5386-2014-4}, pages = {20 Seiten}, year = {2018}, language = {en} } @inproceedings{GoettenHavermannBraunetal.2018, author = {G{\"o}tten, Falk and Havermann, Marc and Braun, Carsten and Gomez, Francisco and Bil, Cees}, title = {On the Applicability of Empirical Drag Estimation Methods for Unmanned Air Vehicle Design Read More: https://arc.aiaa.org/doi/10.2514/6.2018-3192}, series = {2018 Aviation Technology, Integration, and Operations Conference, AIAA AVIATION Forum}, booktitle = {2018 Aviation Technology, Integration, and Operations Conference, AIAA AVIATION Forum}, issn = {1533-385X}, doi = {10.2514/6.2018-3192}, pages = {Article 3192}, year = {2018}, language = {en} } @inproceedings{RuettersWeinheimerBragard2018, author = {R{\"u}tters, Ren{\´e} and Weinheimer, Marius and Bragard, Michael}, title = {Teaching Control Theory with a Simplified Helicopter Model and a Classroom Fitting Hardware Test-Bench}, series = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)}, booktitle = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)}, isbn = {978-1-5386-6903-7}, doi = {10.1109/RTUCON.2018.8659871}, year = {2018}, language = {en} } @inproceedings{BragardHoekHoegenetal.2018, author = {Bragard, Michael and Hoek, Hauke van and Hoegen, Anne von and Doncker, Rik W. De}, title = {Motivation-based Learning: Teaching Fundamentals of Electrical Engineering with an LED Spinning Top}, series = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)}, booktitle = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)}, isbn = {978-1-5386-6903-7}, doi = {10.1109/RTUCON.2018.8659810}, pages = {1 -- 6}, year = {2018}, language = {en} } @inproceedings{BindzusBragard2018, author = {Bindzus, Manuel and Bragard, Michael}, title = {Motivating Intuitive Understanding of the Switched Reluctance Machine in the Education of Undergraduate Students}, series = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)}, booktitle = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)}, isbn = {978-1-5386-6903-7}, doi = {10.1109/RTUCON.2018.8659870}, pages = {1 -- 6}, year = {2018}, language = {en} } @article{WilsonDickieSchreiteretal.2018, author = {Wilson, C. E. and Dickie, A. P. and Schreiter, K. and Wehr, R. and Wilson, E. M. and Bial, J. and Scheer, Nico and Wilson, I. D. and Riley, R. J.}, title = {The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice}, series = {Archives of Toxicology}, volume = {92}, journal = {Archives of Toxicology}, number = {6}, publisher = {Springer}, issn = {1432-0738}, doi = {10.1007/s00204-018-2212-1}, pages = {1953 -- 1967}, year = {2018}, abstract = {The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.}, language = {en} } @inproceedings{BaaderReiswichBartschetal.2018, author = {Baader, Fabian and Reiswich, M. and Bartsch, M. and Keller, D. and Tiede, E. and Keck, G. and Demircian, A. and Friedrich, M. and Dachwald, Bernd and Sch{\"u}ller, K. and Lehmann, R. and Chojetzki, R. and Durand, C. and Rapp, L. and Kowalski, Julia and F{\"o}rstner, R.}, title = {VIPER - Student research on extraterrestrical ice penetration technology}, series = {Proceedings of the 2nd Symposium on Space Educational Activities}, booktitle = {Proceedings of the 2nd Symposium on Space Educational Activities}, pages = {1 -- 6}, year = {2018}, abstract = {Recent analysis of scientific data from Cassini and earth-based observations gave evidence for a global ocean under a surrounding solid ice shell on Saturn's moon Enceladus. Images of Enceladus' South Pole showed several fissures in the ice shell with plumes constantly exhausting frozen water particles, building up the E-Ring, one of the outer rings of Saturn. In this southern region of Enceladus, the ice shell is considered to be as thin as 2 km, about an order of magnitude thinner than on the rest of the moon. Under the ice shell, there is a global ocean consisting of liquid water. Scientists are discussing different approaches the possibilities of taking samples of water, i.e. by melting through the ice using a melting probe. FH Aachen UAS developed a prototype of maneuverable melting probe which can navigate through the ice that has already been tested successfully in a terrestrial environment. This means no atmosphere and or ambient pressure, low ice temperatures of around 100 to 150K (near the South Pole) and a very low gravity of 0,114 m/s^2 or 1100 μg. Two of these influencing measures are about to be investigated at FH Aachen UAS in 2017, low ice temperature and low ambient pressure below the triple point of water. Low gravity cannot be easily simulated inside a large experiment chamber, though. Numerical simulations of the melting process at RWTH Aachen however are showing a gravity dependence of melting behavior. Considering this aspect, VIPER provides a link between large-scale experimental simulations at FH Aachen UAS and numerical simulations at RWTH Aachen. To analyze the melting process, about 90 seconds of experiment time in reduced gravity and low ambient pressure is provided by the REXUS rocket. In this time frame, the melting speed and contact force between ice and probes are measured, as well as heating power and a two-dimensional array of ice temperatures. Additionally, visual and infrared cameras are used to observe the melting process.}, language = {en} } @article{RauppSchmittWalzetal.2018, author = {Raupp, Sebastian M. and Schmitt, Marcel and Walz, Anna-Lena and Diehm, Ralf and Hummel, Helga and Scharfer, Philip and Schabel, Wilhelm}, title = {Slot die stripe coating of low viscous fluids}, series = {Journal of Coatings Technology and Research}, volume = {15}, journal = {Journal of Coatings Technology and Research}, number = {5}, publisher = {Springer}, issn = {1935-3804}, doi = {10.1007/s11998-017-0039-y}, pages = {899 -- 911}, year = {2018}, abstract = {Slot die coating is applied to deposit thin and homogenous films in roll-to-roll and sheet-to-sheet applications. The critical step in operation is to choose suitable process parameters within the process window. In this work, we investigate an upper limit for stripe coatings. This maximum film thickness is characterized by stripe merging which needs to be avoided in a stable process. It is shown that the upper limit reduces the process window for stripe coatings to a major extent. As a result, stripe coatings at large coating gaps and low viscosities are only possible for relatively thick films. Explaining the upper limit, a theory of balancing the side pressure in the gap region in the cross-web direction has been developed.}, language = {en} } @article{HeinkeKnickerAlbracht2018, author = {Heinke, Lars N. and Knicker, Axel J. and Albracht, Kirsten}, title = {Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes}, series = {Isokinetics and Exercise Science}, volume = {26}, journal = {Isokinetics and Exercise Science}, number = {4}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1878-5913}, doi = {10.3233/IES-184111}, pages = {265 -- 274}, year = {2018}, abstract = {BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results.}, language = {en} } @article{LauraDrechslerErdtetal.2018, author = {Laura, C.O. and Drechsler, Klaus and Erdt, M. and Wesarg, S. and Bale, R.}, title = {Intervention assessment tool for primary tumors in the liver}, series = {Current Directions in Biomedical Engineering}, volume = {4}, journal = {Current Directions in Biomedical Engineering}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {2364-5504}, doi = {10.1515/cdbme-2018-0081}, pages = {337 -- 340}, year = {2018}, abstract = {After a liver tumor intervention the medical doctor has to compare both pre and postoperative CT acquisitions to ensure that all carcinogenic cells are destroyed. A correct assessment of the intervention is of vital importance, since it will reduce the probability of tumor recurrence. Some methods have been proposed to support the medical doctors during the assessment process, however, all of them focus on secondary tumors. In this paper a tool is presented that enables the outcome validation for both primary and secondary tumors. Therefore, a multiphase registration (preoperative arterial and portal phases) followed by a registration between the pre and postoperative CT images is carried out. The first registration is in charge of the primary tumors that are only visible in the arterial phase. The secondary tumors will be incorporated in the second registration step. Finally, the part of the tumor that was not covered by the necrosis is quantified and visualized. The method has been tested in 9 patients, with an average registration error of 1.41 mm.}, language = {en} } @inproceedings{SerrorHenzeHacketal.2018, author = {Serror, Martin and Henze, Martin and Hack, Sacha and Schuba, Marko and Wehrle, Klaus}, title = {Towards in-network security for smart homes}, series = {13th International Conference on Availability, Reliability and Security, ARES 2018; Hamburg; Germany; 27 August 2018 through 30 August 2018}, booktitle = {13th International Conference on Availability, Reliability and Security, ARES 2018; Hamburg; Germany; 27 August 2018 through 30 August 2018}, isbn = {978-145036448-5}, doi = {10.1145/3230833.3232802}, pages = {Article numer 3232802}, year = {2018}, language = {en} } @inproceedings{WiesenEngemannLimpertetal.2018, author = {Wiesen, Patrick and Engemann, Heiko and Limpert, Nicolas and Kallweit, Stephan}, title = {Learning by Doing - Mobile Robotics in the FH Aachen ROS Summer School}, series = {European Robotics Forum 2018, TRROS18 Workshop}, booktitle = {European Robotics Forum 2018, TRROS18 Workshop}, pages = {47 -- 58}, year = {2018}, language = {en} } @inproceedings{PfaffMelcherFranzen2018, author = {Pfaff, Raphael and Melcher, Karin and Franzen, Julian}, title = {Rare event simulation to optimise maintenance intervals of safety critical redundant subsystems}, series = {Proceedings of the European Conference of the PHM Society}, volume = {4}, booktitle = {Proceedings of the European Conference of the PHM Society}, number = {1}, pages = {1 -- 6}, year = {2018}, language = {en} }