@article{AkimbekovMansurovJandosovetal.2013, author = {Akimbekov, Nuraly Shardarbekovich and Mansurov, Zulkhair and Jandosov, J. and Digel, Ilya and Gossmann, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A.}, title = {Wound healing activity of carbonized rice husk}, publisher = {Trans Tech Publications, Switzerland}, address = {B{\"a}ch}, year = {2013}, abstract = {The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.}, subject = {Wundheilung}, language = {en} } @article{AlexyukBogoyavlenskiyAlexyuketal.2021, author = {Alexyuk, Madina and Bogoyavlenskiy, Andrey and Alexyuk, Pavel and Moldakhanov, Yergali and Berezin, Vladimir and Digel, Ilya}, title = {Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity}, series = {MicrobiologyOpen}, volume = {10}, journal = {MicrobiologyOpen}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {2045-8827}, doi = {10.1002/mbo3.1142}, pages = {1 -- 10}, year = {2021}, abstract = {Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40\% and 37\% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.}, language = {en} } @article{AlnemerKotliarNeuhausetal.2023, author = {Alnemer, Momin Sami Mohammad and Kotliar, Konstantin and Neuhaus, Valentin and Pape, Hans-Christoph and Ciritsis, Bernhard D.}, title = {Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model}, series = {Cost Effectiveness and Resource Allocation}, journal = {Cost Effectiveness and Resource Allocation}, number = {21, Article number: 77}, publisher = {Springer Nature}, issn = {1478-7547}, doi = {10.1186/s12962-023-00482-4}, pages = {12 Seiten}, year = {2023}, abstract = {Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare \& Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10\% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10\% fracture risk reduction, model A costs between \$8,850 and \$46,940 per quality-adjusted life-year (\$/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8\% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side's prophylaxis, the patient's age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between \$11,000/QALY and \$74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.}, language = {en} } @inproceedings{AridaKloockSchoening2006, author = {Arida, Hassan A. and Kloock, Joachim P. and Sch{\"o}ning, Michael Josef}, title = {Novel organic membrane-based thin-film microsensors for the determination of heavy metal cations}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1545}, year = {2006}, abstract = {A first step towards the fabrication and electrochemical evaluation of thin-film microsensors based on organic PVC membranes for the determination of Hg(II), Cd(II), Pb(II) and Cu(II) ions in solutions has been realised. The membrane-coating mixture used in the preparation of this new type of microsensors is incorporating PVC as supporting matrix, o-nitrophenyloctylether (o-NPOE) as solvent mediator and a recently synthesized Hg[dimethylglyoxime(phene)]2+ and Bis-(4-hydroxyacetophenone)-ethylenediamine as electroactive materials for Hg(II) and Cd(II), respectively. A set of three commercialised ionophores for Cd(II), Pb(II) and Cu(II) has been also used for comparison. Thin-film microsensors based on these membranes showed a Nernstian response of slope (26-30 mV/dec.) for the respective tested cations. The potentiometric response characteristics (linear range, pH range, detection limit and response time) are comparable with those obtained by conventional membranes as well as coated wire electrodes prepared from the same membrane. The realisation of the new organic membrane-based thin-film microsensors overcomes the problem of an insufficient selectivity of solid-state-based thinfilm sensors.}, subject = {Biosensor}, language = {en} } @inproceedings{ArinkinDigel2009, author = {Arinkin, Vladimir and Digel, Ilya}, title = {Water bridge phenomenon : [abstract]}, year = {2009}, abstract = {One of interesting but not well known water properties is related to appearance of highly ordered structures in response to strong electrical field. In 1893 Sir William Armstrong placed a cotton thread between two wine glasses filled with chemically pure water. When high DC voltage was applied between the glasses, a connection consisting of water formed, producing a "water bridge"}, subject = {Hydrodynamik}, language = {en} } @inproceedings{ArtmannDigelLinderetal.2011, author = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Temiz Artmann, Ayseg{\"u}l}, title = {Biophysical and Engineering Contributions to Plant Research}, year = {2011}, abstract = {Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in-situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.}, subject = {Pflanzenphysiologie}, language = {en} } @inproceedings{ArtmannStadlerEmbsetal.2010, author = {Artmann, Gerhard and Stadler, Andreas M. and Embs, Jan P. and Zaccai, Giuseppe and B{\"u}ldt, Georg and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l}, title = {The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]}, year = {2010}, abstract = {The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature}, subject = {H{\"a}moglobin}, language = {en} } @inproceedings{BallmannRaatschenStaat1985, author = {Ballmann, J. and Raatschen, Hans-J{\"u}rgen and Staat, Manfred}, title = {High stress intensities in focussing zones of waves}, doi = {10.1016/B978-0-444-42520-1.50015-3}, year = {1985}, abstract = {The propagation of mechanical waves in plates of isotropic elastic material is investigated. After a short introduction to the understanding of focussing of stress waves in a plate with a curved boundary the method of characteristics is applied to a plate of hyperelastic material. Using this method the propagation of acceleration waves is discussed. Based on this a numerical difference scheme is developed for solving initial-boundary-value problems and applied to two examples: propagation of a point disturbance in a homogeneously finitely strained non-linear elastic plate and geometrical focussing in al linear elastic plate.}, subject = {Technische Mechanik}, language = {en} } @inproceedings{BarekFischerNavratiletal.2006, author = {Barek, Jiri and Fischer, Jan and Navratil, Tomas and Peckova, Karolina and Yosypchuk, Bogdan}, title = {Silver solid amalgam electrodes as sensors for chemical carcinogens}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1554}, year = {2006}, abstract = {The applicability of differential pulse voltammetry (DPV) and adsorptive stripping voltammetry (AdSV) at a non-toxic meniscus-modified silver solid amalgam electrode (m-AgSAE) for the determination of trace amounts of genotoxic substances was demonstrated on the determination of micromolar and submicromolar concentrations of 3-nitrofluoranthene using methanol - 0.01 mol L-1 NaOH (9:1) mixture as a base electrolyte and of Ostazine Orange using 0.01 mol L-1 NaOH as a base electrolyte.}, subject = {Biosensor}, language = {en} } @inproceedings{BaronasIvanauskasKulys2006, author = {Baronas, Romas and Ivanauskas, Feliksas and Kulys, Juozas}, title = {Mathematical modeling of biosensors based on an array of enzyme microreactors}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1569}, year = {2006}, abstract = {This paper presents a two-dimensional-in-space mathematical model of biosensors based on an array of enzyme microreactors immobilised on a single electrode. The modeling system acts under amperometric conditions. The microreactors were modeled by particles and by strips. The model is based on the diffusion equations containing a nonlinear term related to the Michaelis-Menten kinetics of the enzymatic reaction. The model involves three regions: an array of enzyme microreactors where enzyme reaction as well as mass transport by diffusion takes place, a diffusion limiting region where only the diffusion takes place, and a convective region, where the analyte concentration is maintained constant. Using computer simulation, the influence of the geometry of the microreactors and of the diffusion region on the biosensor response was investigated. The digital simulation was carried out using the finite difference technique.}, subject = {Biosensor}, language = {en} } @article{BaroudWuBohneretal.2003, author = {Baroud, G. and Wu, J.Z. and Bohner, M and Sponagel, Stefan and Steffen, T.}, title = {How to determine the permeability for cement infiltration into osteoporotic cancellous bone}, series = {Medical Engineering \& Physics. 25 (2003), H. 4}, journal = {Medical Engineering \& Physics. 25 (2003), H. 4}, issn = {1350-4533}, pages = {283 -- 288}, year = {2003}, abstract = {Cement augmentation is an emerging surgical procedure in which bone cement is used to infiltrate and reinforce osteoporotic vertebrae. Although this infiltration procedure has been widely applied, it is performed empirically and little is known about the flow characteristics of cement during the injection process. We present a theoretical and experimental approach to investigate the intertrabecular bone permeability during the infiltration procedure. The cement permeability was considered to be dependent on time, bone porosity, and cement viscosity in our analysis. In order to determine the time-dependent permeability, ten cancellous bone cores were harvested from osteoporotic vertebrae, infiltrated with acrylic cement at a constant flow rate, and the pressure drop across the cores during the infiltration was measured. The viscosity dependence of the permeability was determined based on published experimental data. The theoretical model for the permeability as a function of bone porosity and time was then fit to the testing data. Our findings suggest that the intertrabecular bone permeability depends strongly on time. For instance, the initial permeability (60.89 mm4/N.s) reduced to approximately 63\% of its original value within 18 seconds. This study is the first to analyze cement flow through osteoporotic bone. The theoretical and experimental models provided in this paper are generic. Thus, they can be used to systematically study and optimize the infiltration process for clinical practice.}, subject = {Osteoporose}, language = {en} } @article{BassamArtmannHescheleretal.2011, author = {Bassam, Rasha and Artmann, Gerhard and Hescheler, J{\"u}rgen and Graef, T. and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Arinkin, Vladimir and Gossmann, Matthias and Digel, Ilya}, title = {Alterations in human hemoglobin structure related to red blood cell storage}, year = {2011}, abstract = {The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing.}, subject = {H{\"a}moglobin}, language = {en} } @inproceedings{BassamDigelArtmann2009, author = {Bassam, Rasha and Digel, Ilya and Artmann, Gerhard}, title = {Effect of nitric oxide on protein thermal stability : [abstract]}, year = {2009}, abstract = {As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not.}, subject = {Stickstoffmonoxid}, language = {en} } @inproceedings{BhattaraiFrotscherSoraetal.2014, author = {Bhattarai, Aroj and Frotscher, Ralf and Sora, M.-C. and Staat, Manfred}, title = {A 3D finite element model of the female pelvic floor for the reconstruction of urinary incontinence}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {1 -- 12}, year = {2014}, language = {en} } @article{BogoyavlenskiyDigelBerezin1997, author = {Bogoyavlenskiy, A. P. and Digel, Ilya and Berezin, V. E.}, title = {Assessment of dot-blot ELISA sensitivity on membrane sorbent using various peroxidase substrates}, year = {1997}, abstract = {The sensitivity of the peroxidase reaction in dot-blot ELISA significantly depends on the substrate. The highest sensitivity is observed using benzidine and diamine- phenol combinations as the substrates due to the reaction of the coupled oxidation (NADI)}, subject = {Enzyme-linked immunosorbent assay}, language = {en} } @article{BornheimGriegerBlanecketal.2024, author = {Bornheim, Tobias and Grieger, Niklas and Blaneck, Patrick Gustav and Bialonski, Stephan}, title = {Speaker Attribution in German Parliamentary Debates with QLoRA-adapted Large Language Models}, series = {Journal for language technology and computational linguistics : JLCL}, volume = {37}, journal = {Journal for language technology and computational linguistics : JLCL}, number = {1}, publisher = {Gesellschaft f{\"u}r Sprachtechnologie und Computerlinguistik}, address = {Regensburg}, issn = {2190-6858}, doi = {10.21248/jlcl.37.2024.244}, pages = {13 Seiten}, year = {2024}, abstract = {The growing body of political texts opens up new opportunities for rich insights into political dynamics and ideologies but also increases the workload for manual analysis. Automated speaker attribution, which detects who said what to whom in a speech event and is closely related to semantic role labeling, is an important processing step for computational text analysis. We study the potential of the large language model family Llama 2 to automate speaker attribution in German parliamentary debates from 2017-2021. We fine-tune Llama 2 with QLoRA, an efficient training strategy, and observe our approach to achieve competitive performance in the GermEval 2023 Shared Task On Speaker Attribution in German News Articles and Parliamentary Debates. Our results shed light on the capabilities of large language models in automating speaker attribution, revealing a promising avenue for computational analysis of political discourse and the development of semantic role labeling systems.}, language = {en} } @inproceedings{BukhariYang2006, author = {Bukhari, Syed Faisal Ahmed and Yang, Wuqiang}, title = {Multi-interface level sensors and new development in monitoring and control of oil separators}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1498}, year = {2006}, abstract = {In the oil industry, huge saving may be made if suitable multi-interface level measurement systems are employed for effectively monitoring crude oil separators and efficient control of their operation. A number of techniques, e.g. externally mounted displacers, differential pressure transmitters and capacitance rod devices, have been developed to measure the separation process with gas, oil, water and other components. Because of the unavailability of suitable multi-interface level measurement systems, oil separators are currently operated by the trial-and-error approach. In this paper some conventional techniques, which have been used for level measurement in industry, and new development are discussed.}, subject = {Biosensor}, language = {en} } @inproceedings{BurgazziFioriniDeMagistrisetal.1998, author = {Burgazzi, L. and Fiorini, F. and De Magistris, W. (u.a.) and Lensa, W. von and Staat, Manfred and Altes, J.}, title = {Reliability Assessment of Passive Safety Systems}, series = {Proceedings of the 6th International Conference on Nuclear Engineering : ICONE : May 10 - 14, 1998, San Diego, Calif.}, booktitle = {Proceedings of the 6th International Conference on Nuclear Engineering : ICONE : May 10 - 14, 1998, San Diego, Calif.}, publisher = {American Society of Mechanical Engineers}, address = {New York}, year = {1998}, language = {en} } @inproceedings{ChaiybounTrauteKiesewetteretal.2006, author = {Chaiyboun, Ali and Traute, R{\"u}diger and Kiesewetter, Olaf and Ahlers, Simon and M{\"u}ller, Gerhard and Doll, Theodor}, title = {Modular analytical multicomponent analysis in gas sensor arrays}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1358}, year = {2006}, abstract = {A multi-sensor system is a chemical sensor system which quantitatively and qualitatively records gases with a combination of cross-sensitive gas sensor arrays and pattern recognition software. This paper addresses the issue of data analysis for identification of gases in a gas sensor array. We introduce a software tool for gas sensor array configuration and simulation. It concerns thereby about a modular software package for the acquisition of data of different sensors. A signal evaluation algorithm referred to as matrix method was used specifically for the software tool. This matrix method computes the gas concentrations from the signals of a sensor array. The software tool was used for the simulation of an array of five sensors to determine gas concentration of CH4, NH3, H2, CO and C2H5OH. The results of the present simulated sensor array indicate that the software tool is capable of the following: (a) identify a gas independently of its concentration; (b) estimate the concentration of the gas, even if the system was not previously exposed to this concentration; (c) tell when a gas concentration exceeds a certain value. A gas sensor data base was build for the configuration of the software. With the data base one can create, generate and manage scenarios and source files for the simulation. With the gas sensor data base and the simulation software an on-line Web-based version was developed, with which the user can configure and simulate sensor arrays on-line.}, subject = {Biosensor}, language = {en} } @inproceedings{DachwaldXuFeldmannetal.2011, author = {Dachwald, Bernd and Xu, Changsheng and Feldmann, Marco and Plescher, Engelbert and Digel, Ilya and Artmann, Gerhard}, title = {Development and testing of a subsurface probe for detection of life in deep ice : [abstract]}, year = {2011}, abstract = {We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named "IceMole", is currently developed, built, and tested at the FH Aachen University of Applied Sciences' Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).}, subject = {Eisschicht}, language = {en} } @article{DigelAkimbekovRogachevetal.2023, author = {Digel, Ilya and Akimbekov, Nuraly and Rogachev, Evgeniy and Pogorelova, Natalia}, title = {Bacterial cellulose produced by Medusomyces gisevii on glucose and sucrose: biosynthesis and structural properties}, series = {Cellulose}, journal = {Cellulose}, publisher = {Springer Science + Business Media}, address = {Dordrecht}, issn = {1572-882X (Online)}, doi = {10.1007/s10570-023-05592-z}, pages = {15 Seiten}, year = {2023}, abstract = {In this work, the effects of carbon sources and culture media on the production and structural properties of bacterial cellulose (BC) synthesized by Medusomyces gisevii have been studied. The culture medium was composed of different initial concentrations of glucose or sucrose dissolved in 0.4\% extract of plain green tea. Parameters of the culture media (titratable acidity, substrate conversion degree etc.) were monitored daily for 20 days of cultivation. The BC pellicles produced on different carbon sources were characterized in terms of biomass yield, crystallinity and morphology by field emission scanning electron microscopy (FE-SEM), atomic force microscopy and X-ray diffraction. Our results showed that Medusomyces gisevii had higher BC yields in media with sugar concentrations close to 10 g L-1 after a 18-20 days incubation period. Glucose in general lead to a higher BC yield (173 g L-1) compared to sucrose (163.5 g L-1). The BC crystallinity degree and surface roughness were higher in the samples synthetized from sucrose. Obtained FE-SEM micrographs show that the BC pellicles synthesized in the sucrose media contained densely packed tangles of cellulose fibrils whereas the BC produced in the glucose media displayed rather linear geometry of the BC fibrils without noticeable aggregates.}, language = {en} } @inproceedings{DigelDachwaldArtmannetal.2009, author = {Digel, Ilya and Dachwald, Bernd and Artmann, Gerhard and Linder, Peter and Funke, O.}, title = {A concept of a probe for particle analysis and life detection in icy environments}, year = {2009}, abstract = {A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa's ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live.}, subject = {Sonde}, language = {en} } @inproceedings{DigelDemirciTrzewiketal.2004, author = {Digel, Ilya and Demirci, Taylan and Trzewik, J{\"u}rgen and Linder, Peter and Temiz Artmann, Ayseg{\"u}l}, title = {Fibroblast response to mechanical stress: role of the adhesion substrate : [abstract]}, year = {2004}, abstract = {Mechanical stimulation of the cells resulted in evident changes in the cell morphology, protein composition and gene expression. Microscopically, additional formation of stress fibers accompanied by cell re-arrangements in a monolayer was observed. Also, significant activation of p53 gene was revealed as compared to control. Interestingly, the use of CellTech membrane coating induced cell death after mechanical stress had been applied. Such an effect was not detected when fibronectin had been used as an adhesion substrate.}, subject = {Fibroblast}, language = {en} } @inproceedings{DigelLeimenaDachwaldetal.2010, author = {Digel, Ilya and Leimena, W. and Dachwald, Bernd and Linder, Peter and Porst, Dariusz and Kayser, Peter and Funke, O. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {In-situ biological decontamination of an ice melting probe : [abstract]}, year = {2010}, abstract = {The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.}, subject = {Sonde}, language = {en} } @inproceedings{DigelTemizArtmannArtmannetal.2003, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Nojima, H.}, title = {Plasma cluster ions (PCI) influence on microbial cells viability : [abstract]}, year = {2003}, abstract = {Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new plasma cluster device releases into the air positive and negative ions, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. A lot of phenomenological tests of the PCI air purification technology on microbial cells have been conducted. And, in most cases, it has been shown that PCI demonstrate strongly pronounced killing effect. Although, the particular mechanisms of PCI action are still not evident. We studied variations in resistance to PCI among gram-positive airborne microorganisms, as well as some dose-dependent, spatial, cultural and biochemical properties of PCI action in respect of Staphylococcus spp, Enterococcus spp, Micrococcus spp.}, subject = {Clusterion}, language = {en} } @inproceedings{DigelTemizArtmannNojimaetal.2003, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard}, title = {Effects of plasma generated ions on bacteria : [poster]}, year = {2003}, abstract = {Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death.}, subject = {Clusterion}, language = {en} } @inproceedings{DigelTemizArtmannNojimaetal.2003, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard}, title = {Some peculiarities of application of cluster ions generated by plasma in respect of indoor air purification :[abstract]}, year = {2003}, abstract = {Recently, the SHARP Corporation, Japan, has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology using plasma discharge to generate cluster ions. The new plasma cluster device releases positive and negative ions into the air, which are able to decompose and deactivate harmful airborne substances by chemical reactions. Because cluster ions consist of positive and negative ions that normally exist in the natural world, they are completely harmless and safe to humans. The amount of ozone generated by cluster ions is less than 0.01 ppm, which is significantly less than the 0.05-ppm standard for industrial operations and consumer electronics. This amount, thus, has no harming effects whatsoever on the human body. But particular properties and chemical processes in PCI treatment are still under study. It has been shown that PCI in most cases show strongly pronounced irreversible killing effects in respect of airborne microflora due to free-radical induced reactions and can be considered as a potent technology to disinfect both home, medical and industrial appliances.}, subject = {Clusterion}, language = {en} } @inproceedings{DigelTemizArtmannNojimaetal.2003, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard}, title = {Plasma-generated cluster ions' effects on indoor microflora : [abstract]}, year = {2003}, abstract = {Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions® (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new Plasma Cluster Device releases positive and negative ions into the air, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. In the past, phenomenological tests on the efficacy of the PCI air purification technology on microbial cells have been conducted. In most cases, it has been shown that PCI demonstrated strongly pronounced killing effects on microorganisms. However, the particular mechanisms of PCI action still have to be uncovered.}, subject = {Clusterion}, language = {en} } @inproceedings{DuongJungFrotscheretal.2016, author = {Duong, Minh Tuan and Jung, Alexander and Frotscher, Ralf and Staat, Manfred}, title = {A 3D electromechanical FEM-based model for cardiac tissue}, series = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016}, booktitle = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016}, editor = {Papadrakakis, M.}, pages = {13 S.}, year = {2016}, language = {en} } @inproceedings{DuongStaat2014, author = {Duong, Minh Tuan and Staat, Manfred}, title = {A face-based smoothed finite element method for hyperelastic models and tissue growth}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {1 -- 12}, year = {2014}, language = {en} } @inproceedings{ElBashirDigel2009, author = {ElBashir, Rasha and Digel, Ilya}, title = {Effect of nitric oxide gas on hydrogels : [abstract]}, year = {2009}, abstract = {The results support our theory that the NO gas has an influence in increasing the translational diffusion of hydrogels and it accelerates the melting process of the gels.}, subject = {Stickstoffmonoxid}, language = {en} } @inproceedings{FrotscherDuongStaat2015, author = {Frotscher, Ralf and Duong, Minh Tuan and Staat, Manfred}, title = {Simulating beating cardiomyocytes with electromechanical coupling}, series = {II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)}, booktitle = {II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)}, organization = {International Conference on Biomedical Technology <2, 2015, Hannover>}, pages = {1 -- 2}, year = {2015}, language = {en} } @inproceedings{FrotscherKochRaatschenetal.2014, author = {Frotscher, Ralf and Koch, Jan-Peter and Raatschen, Hans-J{\"u}rgen and Staat, Manfred}, title = {Evaluation of a computational model for drug action on cardiac tissue}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {1 -- 12}, year = {2014}, language = {en} } @inproceedings{FrotscherStaat2015, author = {Frotscher, Ralf and Staat, Manfred}, title = {Homogenization of a cardiac tissue construct}, series = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France}, booktitle = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France}, editor = {Nithiarasu, Perumal}, publisher = {CMBE}, address = {[s.l.]}, issn = {2227-9385}, pages = {645 -- 648}, year = {2015}, language = {en} } @inproceedings{FoersterStockMontanarietal.2006, author = {F{\"o}rster, Arnold and Stock, J{\"u}rgen and Montanari, Simone and Lepsa, Mihail Ion and L{\"u}th, Hans}, title = {Fabrication and characterisation of GaAs Gunn Diode Chips for applications at 77 GHz in automotive industry}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1462}, year = {2006}, abstract = {GaAs-based Gunn diodes with graded AlGaAs hot electron injector heterostructures have been developed under the special needs in automotive applications. The fabrication of the Gunn diode chips was based on total substrate removal and processing of integrated Au heat sinks. Especially, the thermal and RF behavior of the diodes have been analyzed by DC, impedance and S-parameter measurements. The electrical investigations have revealed the functionality of the hot electron injector. An optimized layer structure could fulfill the requirements in adaptive cruise control (ACC) systems at 77 GHz with typical output power between 50 and 90 mW.}, subject = {Biosensor}, language = {en} } @article{GorissenStaatLaack2012, author = {Gorissen, P. and Staat, Manfred and Laack, Walter van}, title = {Experimentelle Kraftmessungen als Beitrag zur Wirksamkeitsbeurteilung von Schienbeinschonern im Fußballsport}, series = {OUP Zeitschrift f{\"u}r die orthop{\"a}dische und unfallchirurgische Praxis}, volume = {1}, journal = {OUP Zeitschrift f{\"u}r die orthop{\"a}dische und unfallchirurgische Praxis}, number = {1}, publisher = {Deutscher {\"A}rzte-Verlag}, address = {K{\"o}ln}, issn = {2193-5785}, doi = {10.3238/oup.2012.0010-0015}, pages = {10 -- 15}, year = {2012}, abstract = {Diese Studie besch{\"a}ftigte sich mit der D{\"a}mpfungswirkung von Schienbeinschonern, wie sie beim Fußball zum Einsatz kommen. Sie wurde mit Hilfe eines Pendelhammers durchgef{\"u}hrt, der verschiedene Aufschlagkr{\"a}fte auf die Schoner erm{\"o}glichte. Dabei wurde deutlich, dass Schienbeinschoner die beste Wirkung bei Maximalkr{\"a}ften unterhalb von 5kN erreichen k{\"o}nnen, dass bei gr{\"o}ßerer Belastung allerdings Verbesserungsbedarf besteht. Hierf{\"u}r konnte, u.a. durch den Einsatz neuer Materialien, ein guter Ansatzpunkt im „ad{\"a}quaten Zusammenspiel von Schale und Polsterung" der Schoner gefunden werden. Die Untersuchung hat weiterhin gezeigt, dass zumindest teilweise eine deutliche Verbesserung der D{\"a}mpfungswirkung der Schienbeinschoner in den letzten Jahren erreicht werden konnte.}, subject = {Fußball}, language = {de} } @article{GrajewskiKleefeld2023, author = {Grajewski, Matthias and Kleefeld, Andreas}, title = {Detecting and approximating decision boundaries in low-dimensional spaces}, series = {Numerical Algorithms}, volume = {93}, journal = {Numerical Algorithms}, number = {4}, publisher = {Springer Science+Business Media}, address = {Dordrecht}, issn = {1572-9265}, pages = {35 Seiten}, year = {2023}, abstract = {A method for detecting and approximating fault lines or surfaces, respectively, or decision curves in two and three dimensions with guaranteed accuracy is presented. Reformulated as a classification problem, our method starts from a set of scattered points along with the corresponding classification algorithm to construct a representation of a decision curve by points with prescribed maximal distance to the true decision curve. Hereby, our algorithm ensures that the representing point set covers the decision curve in its entire extent and features local refinement based on the geometric properties of the decision curve. We demonstrate applications of our method to problems related to the detection of faults, to multi-criteria decision aid and, in combination with Kirsch's factorization method, to solving an inverse acoustic scattering problem. In all applications we considered in this work, our method requires significantly less pointwise classifications than previously employed algorithms.}, language = {en} } @article{GriegerSchwabedalWendeletal.2021, author = {Grieger, Niklas and Schwabedal, Justus T. C. and Wendel, Stefanie and Ritze, Yvonne and Bialonski, Stephan}, title = {Automated scoring of pre-REM sleep in mice with deep learning}, series = {Scientific Reports}, volume = {11}, journal = {Scientific Reports}, number = {Art. 12245}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-021-91286-0}, year = {2021}, abstract = {Reliable automation of the labor-intensive manual task of scoring animal sleep can facilitate the analysis of long-term sleep studies. In recent years, deep-learning-based systems, which learn optimal features from the data, increased scoring accuracies for the classical sleep stages of Wake, REM, and Non-REM. Meanwhile, it has been recognized that the statistics of transitional stages such as pre-REM, found between Non-REM and REM, may hold additional insight into the physiology of sleep and are now under vivid investigation. We propose a classification system based on a simple neural network architecture that scores the classical stages as well as pre-REM sleep in mice. When restricted to the classical stages, the optimized network showed state-of-the-art classification performance with an out-of-sample F1 score of 0.95 in male C57BL/6J mice. When unrestricted, the network showed lower F1 scores on pre-REM (0.5) compared to the classical stages. The result is comparable to previous attempts to score transitional stages in other species such as transition sleep in rats or N1 sleep in humans. Nevertheless, we observed that the sequence of predictions including pre-REM typically transitioned from Non-REM to REM reflecting sleep dynamics observed by human scorers. Our findings provide further evidence for the difficulty of scoring transitional sleep stages, likely because such stages of sleep are under-represented in typical data sets or show large inter-scorer variability. We further provide our source code and an online platform to run predictions with our trained network.}, language = {en} } @article{HeelDiktaBraekers2021, author = {Heel, Mareike van and Dikta, Gerhard and Braekers, Roel}, title = {Bootstrap based goodness‑of‑fit tests for binary multivariate regression models}, series = {Journal of the Korean Statistical Society}, volume = {51}, journal = {Journal of the Korean Statistical Society}, publisher = {Springer Nature}, address = {Singapur}, issn = {2005-2863 (Online)}, doi = {10.1007/s42952-021-00142-4}, pages = {28 Seiten}, year = {2021}, abstract = {We consider a binary multivariate regression model where the conditional expectation of a binary variable given a higher-dimensional input variable belongs to a parametric family. Based on this, we introduce a model-based bootstrap (MBB) for higher-dimensional input variables. This test can be used to check whether a sequence of independent and identically distributed observations belongs to such a parametric family. The approach is based on the empirical residual process introduced by Stute (Ann Statist 25:613-641, 1997). In contrast to Stute and Zhu's approach (2002) Stute \& Zhu (Scandinavian J Statist 29:535-545, 2002), a transformation is not required. Thus, any problems associated with non-parametric regression estimation are avoided. As a result, the MBB method is much easier for users to implement. To illustrate the power of the MBB based tests, a small simulation study is performed. Compared to the approach of Stute \& Zhu (Scandinavian J Statist 29:535-545, 2002), the simulations indicate a slightly improved power of the MBB based method. Finally, both methods are applied to a real data set.}, language = {en} } @inproceedings{HeerRedkowitzKraft2008, author = {Heer, Thomas and Redkowitz, Daniel and Kraft, Bodo}, title = {Tool Support for the Integration of Light-Weight Ontologies}, isbn = {978-3-642-00670-8}, year = {2008}, abstract = {Abstract of the authors: In many areas of computer science ontologies become more and more important. The use of ontologies for domain modeling often brings up the issue of ontology integration. The task of merging several ontologies, covering specific subdomains, into one united ontology has to be solved. Many approaches for ontology integration aim at automating the process of ontology alignment. However, a complete automation is not feasible, and user interaction is always required. Nevertheless, most ontology integration tools offer only very limited support for the interactive part of the integration process. In this paper, we present a novel approach for the interactive integration of ontologies. The result of the ontology integration is incrementally updated after each definition of a correspondence between ontology elements. The user is guided through the ontologies to be integrated. By restricting the possible user actions, the integrity of all defined correspondences is ensured by the tool we developed. We evaluated our tool by integrating different regulations concerning building design.}, subject = {Ontologie }, language = {de} } @inproceedings{HeitzerStaat2000, author = {Heitzer, M. and Staat, Manfred}, title = {Direct FEM approach to design-by-analysis of pressurized components}, year = {2000}, abstract = {Abstracts of the ACHEMA 2000 - International Meeting on Chemical Engineering, Environmental Protection and Biotechnology, May 22 - 27, 2000. Frankfurt am Main. Achema 2000 : special edition / Linde. [Ed.: Linde AG. Red.: Volker R. Leski]. - Wiesbaden : Linde AG, 2000. - 56 p. : Ill., . - pp: 79 - 81}, subject = {Finite-Elemente-Methode}, language = {en} } @article{JablonskiMuenstermannNorketal.2021, author = {Jablonski, Melanie and M{\"u}nstermann, Felix and Nork, Jasmina and Molinnus, Denise and Muschallik, Lukas and Bongaerts, Johannes and Wagner, Torsten and Keusgen, Michael and Siegert, Petra and Sch{\"o}ning, Michael Josef}, title = {Capacitive field-effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths}, series = {physica status solidi (a) applications and materials science}, volume = {218}, journal = {physica status solidi (a) applications and materials science}, number = {13}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202000765}, pages = {7 Seiten}, year = {2021}, abstract = {An acetoin biosensor based on a capacitive electrolyte-insulator-semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance-voltage, and constant capacitance methods, respectively.}, language = {en} } @article{JablonskiPoghossianKeusgenetal.2021, author = {Jablonski, Melanie and Poghossian, Arshak and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Detection of plant virus particles with a capacitive field-effect sensor}, series = {Analytical and Bioanalytical Chemistry}, volume = {413}, journal = {Analytical and Bioanalytical Chemistry}, publisher = {Springer Nature}, address = {Cham}, issn = {1618-2650}, doi = {10.1007/s00216-021-03448-8}, pages = {5669 -- 5678}, year = {2021}, abstract = {Plant viruses are major contributors to crop losses and induce high economic costs worldwide. For reliable, on-site and early detection of plant viral diseases, portable biosensors are of great interest. In this study, a field-effect SiO2-gate electrolyte-insulator-semiconductor (EIS) sensor was utilized for the label-free electrostatic detection of tobacco mosaic virus (TMV) particles as a model plant pathogen. The capacitive EIS sensor has been characterized regarding its TMV sensitivity by means of constant-capacitance method. The EIS sensor was able to detect biotinylated TMV particles from a solution with a TMV concentration as low as 0.025 nM. A good correlation between the registered EIS sensor signal and the density of adsorbed TMV particles assessed from scanning electron microscopy images of the SiO2-gate chip surface was observed. Additionally, the isoelectric point of the biotinylated TMV particles was determined via zeta potential measurements and the influence of ionic strength of the measurement solution on the TMV-modified EIS sensor signal has been studied.}, language = {en} } @article{JanusAchtsnichtDrinicetal.2023, author = {Janus, Kevin Alexander and Achtsnicht, Stefan and Drinic, Aleksander and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Transient magnesium-based thin-film temperature sensor on a flexible, bioabsorbable substrate for future medical applications}, series = {Applied Research}, journal = {Applied Research}, number = {Accepted manuscript}, publisher = {Wiley-VCH}, issn = {2702-4288 (Print)}, doi = {10.1002/appl.202300102}, pages = {22 Seiten}, year = {2023}, abstract = {In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin-film magnesium-based meander-like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium-based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue-like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium-based layers. The 3-layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C.}, language = {en} } @article{JanusAchtsnichtTempeletal.2023, author = {Janus, Kevin Alexander and Achtsnicht, Stefan and Tempel, Laura and Drinic, Aleksaner and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon}, series = {Physica status solidi : pss. A, Applications and materials science}, volume = {220}, journal = {Physica status solidi : pss. A, Applications and materials science}, number = {22}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300 (Print)}, doi = {10.1002/pssa.202300081}, pages = {Artikel 2300081}, year = {2023}, abstract = {Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5-10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.}, language = {en} } @article{JildehWagnerSchoening2021, author = {Jildeh, Zaid B. and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020}, series = {physica status solidi (a) applications and materials science}, volume = {218}, journal = {physica status solidi (a) applications and materials science}, number = {13}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202000732}, pages = {27 Seiten}, year = {2021}, abstract = {The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.}, language = {en} } @inproceedings{JungFrotscherStaat2018, author = {Jung, Alexander and Frotscher, Ralf and Staat, Manfred}, title = {Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts}, series = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, booktitle = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, pages = {11 Seiten}, year = {2018}, abstract = {The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.}, language = {en} } @inproceedings{JungStaatMueller2014, author = {Jung, Alexander and Staat, Manfred and M{\"u}ller, Wolfram}, title = {Optimization of the flight style in ski jumping}, series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona}, booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona}, editor = {Onate, E.}, organization = {World Congress on Computational Mechanics <11, 2014, Barcelona>}, pages = {799 -- 810}, year = {2014}, language = {en} } @article{KarschuckSchmidtAchtsnichtetal.2023, author = {Karschuck, Tobias and Schmidt, Stefan and Achtsnicht, Stefan and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Multiplexing system for automated characterization of a capacitive field-effect sensor array}, series = {Physica Status Solidi A}, volume = {220}, journal = {Physica Status Solidi A}, number = {22}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300 (Print)}, doi = {10.1002/pssa.202300265}, pages = {7 Seiten}, year = {2023}, abstract = {In comparison to single-analyte devices, multiplexed systems for a multianalyte detection offer a reduced assay time and sample volume, low cost, and high throughput. Herein, a multiplexing platform for an automated quasi-simultaneous characterization of multiple (up to 16) capacitive field-effect sensors by the capacitive-voltage (C-V) and the constant-capacitance (ConCap) mode is presented. The sensors are mounted in a newly designed multicell arrangement with one common reference electrode and are electrically connected to the impedance analyzer via the base station. A Python script for the automated characterization of the sensors executes the user-defined measurement protocol. The developed multiplexing system is tested for pH measurements and the label-free detection of ligand-stabilized, charged gold nanoparticles.}, language = {en} } @inproceedings{KatzWillner2006, author = {Katz, Eugenii and Willner, Itamar}, title = {Magneto-controlled quantized electron transfer to surface-confined redox units and metal nanoparticles}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1528}, year = {2006}, abstract = {Hydrophobic magnetic nanoparticles (NPs) consisting of undecanoate-capped magnetite (Fe3O4, average diameter ca. 5 nm) are used to control quantized electron transfer to surface-confined redox units and metal NPs. A two-phase system consisting of an aqueous electrolyte solution and a toluene phase that includes the suspended undecanoatecapped magnetic NPs is used to control the interfacial properties of the electrode surface. The attracted magnetic NPs form a hydrophobic layer on the electrode surface resulting in the change of the mechanisms of the surface-confined electrochemical processes. A quinone-monolayer modified Au electrode demonstrates an aqueous-type of the electrochemical process (2e-+2H+ redox mechanism) for the quinone units in the absence of the hydrophobic magnetic NPs, while the attraction of the magnetic NPs to the surface results in the stepwise single-electron transfer mechanism characteristic of a dry nonaqueous medium. Also, the attraction of the hydrophobic magnetic NPs to the Au electrode surface modified with Au NPs (ca. 1.4 nm) yields a microenvironment with a low dielectric constant that results in the single-electron quantum charging of the Au NPs.}, subject = {Biosensor}, language = {en} } @article{KaulenSchwabedalSchneideretal.2022, author = {Kaulen, Lars and Schwabedal, Justus T. C. and Schneider, Jules and Ritter, Philipp and Bialonski, Stephan}, title = {Advanced sleep spindle identification with neural networks}, series = {Scientific Reports}, volume = {12}, journal = {Scientific Reports}, number = {Article number: 7686}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-022-11210-y}, pages = {1 -- 10}, year = {2022}, abstract = {Sleep spindles are neurophysiological phenomena that appear to be linked to memory formation and other functions of the central nervous system, and that can be observed in electroencephalographic recordings (EEG) during sleep. Manually identified spindle annotations in EEG recordings suffer from substantial intra- and inter-rater variability, even if raters have been highly trained, which reduces the reliability of spindle measures as a research and diagnostic tool. The Massive Online Data Annotation (MODA) project has recently addressed this problem by forming a consensus from multiple such rating experts, thus providing a corpus of spindle annotations of enhanced quality. Based on this dataset, we present a U-Net-type deep neural network model to automatically detect sleep spindles. Our model's performance exceeds that of the state-of-the-art detector and of most experts in the MODA dataset. We observed improved detection accuracy in subjects of all ages, including older individuals whose spindles are particularly challenging to detect reliably. Our results underline the potential of automated methods to do repetitive cumbersome tasks with super-human performance.}, language = {en} } @inproceedings{KernDikta2009, author = {Kern, Alexander and Dikta, Gerhard}, title = {Probability of damage of electrical and electronic systems due to indirect lightning flashes - investigation of data from German insurance companies}, year = {2009}, abstract = {In the presented paper data collected from the field related to damage statistics of electrical and electronic apparatus in household are reported and investigated. These damages (total number approx. 74000 cases), registered by five German insurance companies in 2005 and 2006, were adviced by customers as caused by lightning overvoltages. With the use of stochastical methods it is possible, to reasses the collected data and to distinguish between cases, which are with high probability caused by lightning overvoltages, and those, which are not. If there was an indication for a direct strike, this case was excluded, so the focus was only on indirect lightning flashes, i.e. only flashes to ground near the structure and flashes to or nearby an incoming service line were investigated. The data from the field contain the location of damaged apparatus (residence of the policy holder) and the distances of the nearest cloud-to-ground stroke to the location of the damage registered by the German lightning location network BLIDS at the date of damage. The statistical data along with some complementary numerical simulations allow to verify the correspondence of the Standards rules used for IEC 62305-2 with the field data and to define some correction needs. The results could lead to a better understanding whether a damage reported to an insurance company is really caused by indirect lightning, or not.}, subject = {Blitzschutz}, language = {en} } @inproceedings{KirchhofKraft2004, author = {Kirchhof, M. and Kraft, Bodo}, title = {UML-based modeling of architectural knowledge and design}, year = {2004}, abstract = {IASSE-2004 - 13th International Conference on Intelligent and Adaptive Systems and Software Engineering eds. W. Dosch, N. Debnath, pp. 245-250, ISCA, Cary, NC, 1-3 July 2004, Nice, France We introduce a UML-based model for conceptual design support in civil engineering. Therefore, we identify required extensions to standard UML. Class diagrams are used for elaborating building typespecific knowledge: Object diagrams, implicitly contained in the architect's sketch, are validated against the defined knowledge. To enable the use of industrial, domain-specific tools, we provide an integrated conceptual design extension. The developed tool support is based on graph rewriting. With our approach architects are enabled to deal with semantic objects during early design phase, assisted by incremental consistency checks.}, subject = {UML}, language = {en} } @inproceedings{KirchhofKraft2011, author = {Kirchhof, Michael and Kraft, Bodo}, title = {Dogmatisches „Entweder agil oder klassisch" im Projektmanagement hat ausgedient - die richtige Mischung macht's}, series = {Projekt-Sternstunden : strahlende Erfolge durch Kompetenz}, booktitle = {Projekt-Sternstunden : strahlende Erfolge durch Kompetenz}, publisher = {GPM}, address = {N{\"u}rnberg}, isbn = {978-3-924841-60-7}, pages = {414 -- 425}, year = {2011}, language = {de} } @inproceedings{KoplinSiemonsOcenValentinetal.2006, author = {Koplin, Tobias J. and Siemons, Maike and Oc{\´e}n-Val{\´e}ntin, C{\´e}sar and Sanders, Daniel and Simon, Ulrich}, title = {Workflow for high throughput screening of gas sensing materials}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1407}, year = {2006}, abstract = {The workflow of a high throughput screening setup for the rapid identification of new and improved sensor materials is presented. The polyol method was applied to prepare nanoparticular metal oxides as base materials, which were functionalised by surface doping. Using multi-electrode substrates and high throughput impedance spectroscopy (HT-IS) a wide range of materials could be screened in a short time. Applying HT-IS in search of new selective gas sensing materials a NO2-tolerant NO sensing material with reduced sensitivities towards other test gases was identified based on iridium doped zinc oxide. Analogous behaviour was observed for iridium doped indium oxide.}, subject = {Biosensor}, language = {en} } @inproceedings{Kraft2004, author = {Kraft, Bodo}, title = {Conceptual design tools for civil engineering}, year = {2004}, abstract = {Applications of Graph Transformations with Industrial Relevance Lecture Notes in Computer Science, 2004, Volume 3062/2004, 434-439, DOI: http://dx.doi.org/10.1007/978-3-540-25959-6_33 This paper gives a brief overview of the tools we have developed to support conceptual design in civil engineering. Based on the UPGRADE framework, two applications, one for the knowledge engineer and another for architects allow to store domain specific knowledge and to use this knowledge during conceptual design. Consistency analyses check the design against the defined knowledge and inform the architect if rules are violated.}, subject = {CAD}, language = {en} } @article{Kraft2003, author = {Kraft, Bodo}, title = {Conceptual design mit ArchiCAD 8 : Forschungsprojekt an der RWTH Aachen}, year = {2003}, abstract = {Projektbericht in GraphisoftNews - Architektur und Bauen in einer vernetzten Welt 3/2003 4 Seiten}, subject = {CAD}, language = {de} } @misc{Kraft2003, author = {Kraft, Bodo}, title = {LexiCAD Step by Step : B{\"u}rogeb{\"a}ude : Erstellen eines Grundrisses mit RoomObjects und LexiCAD}, year = {2003}, abstract = {11 Seiten, 22 Abbildungen 1. Konstruktion des Außenumrisses 2. Festlegung der inneren R{\"a}ume 3. Einf{\"u}gen der RoomLinks 4. Wallgenerator}, subject = {CAD}, language = {de} } @inproceedings{KraftMeyerNagl2002, author = {Kraft, Bodo and Meyer, Oliver and Nagl, Manfred}, title = {Graph technology support for conceptual design in civil engineering}, isbn = {3-18-318004-9}, year = {2002}, abstract = {In: Advances in intelligent computing in engineering : proceedings of the 9.International EG-ICE Workshop ; Darmstadt, (01 - 03 August) 2002 / Martina Schnellenbach-Held ... (eds.) . - D{\"u}sseldorf: VDI-Verl., 2002 .- Fortschritt-Berichte VDI, Reihe 4, Bauingenieurwesen ; 180 ; S. 1-35 The paper describes a novel way to support conceptual design in civil engineering. The designer uses semantical tools guaranteeing certain internal structures of the design result but also the fulfillment of various constraints. Two different approaches and corresponding tools are discussed: (a) Visually specified tools with automatic code generation to determine a design structure as well as fixing various constraints a design has to obey. These tools are also valuable for design knowledge specialist. (b) Extensions of existing CAD tools to provide semantical knowledge to be used by an architect. It is sketched how these different tools can be combined in the future. The main part of the paper discusses the concepts and realization of two prototypes following the two above approaches. The paper especially discusses that specific graphs and the specification of their structure are useful for both tool realization projects.}, subject = {CAD}, language = {en} } @article{KraftNagl2007, author = {Kraft, Bodo and Nagl, Manfred}, title = {Visual Knowledge Specification for Conceptual Design: Definition and Tool Support}, year = {2007}, abstract = {In: Advanced Engineering Informatics. Vol 21, Issue 1, 2007, Pages 67-83 http://dx.doi.org/10.1016/j.aei.2006.10.001 eds. J.C. Kunz, I.F.C. Smith and T. Tomiyama, Elsevier, Seite 1-22 Current CAD tools are not able to support the conceptual design phase, and none of them provides a consistency analysis for sketches produced by architects. This phase is fundamental and crucial for the whole design and construction process of a building. To give architects a better support, we developed a CAD tool for conceptual design and a knowledge specification tool. The knowledge is specific to one class of buildings and it can be reused. Based on a dynamic and domain-specific knowledge ontology, different types of design rules formalize this knowledge in a graph-based form. An expressive visual language provides a user-friendly, human readable representation. Finally, a consistency analysis tool enables conceptual designs to be checked against this formal conceptual knowledge. In this article, we concentrate on the knowledge specification part. For that, we introduce the concepts and usage of a novel visual language and describe its semantics. To demonstrate the usability of our approach, two graph-based visual tools for knowledge specification and conceptual design are explained.}, subject = {CAD}, language = {en} } @inproceedings{KraftNagl2003, author = {Kraft, Bodo and Nagl, Manfred}, title = {Support of Conceptual Design in Civil Engineering by Graph-based Tools}, year = {2003}, abstract = {WS GTaD-2003 - The 1st Workshop on Graph Transformations and Design ed Grabska, E., Seite 6-7, Jagiellonian University Krakow. 2 pages}, subject = {CAD}, language = {de} } @inproceedings{KraftNagl2004, author = {Kraft, Bodo and Nagl, Manfred}, title = {Parameterized specification of conceptual design tools in civil engineering}, year = {2004}, abstract = {Applications of Graph Transformations with Industrial Relevance Lecture Notes in Computer Science, 2004, Volume 3062/2004, 90-105, DOI: 10.1007/978-3-540-25959-6_7 In this paper we discuss how tools for conceptual design in civil engineering can be developed using graph transformation specifications. These tools consist of three parts: (a) for elaborating specific conceptual knowledge (knowledge engineer), (b) for working out conceptual design results (architect), and (c) automatic consistency analyses which guarantee that design results are consistent with the underlying specific conceptual knowledge. For the realization of such tools we use a machinery based on graph transformations. In a traditional PROGRES tool specification the conceptual knowledge for a class of buildings is hard-wired within the specification. This is not appropriate for the experimentation platform approach we present in this paper, as objects and relations for conceptual knowledge are due to many changes, implied by evaluation of their use and corresponding improvements. Therefore, we introduce a parametric specification method with the following characteristics: (1) The underlying specific knowledge for a class of buildings is not fixed. Instead, it is built up as a data base by using the knowledge tools. (2) The specification for the architect tools also does not incorporate specific conceptual knowledge. (3) An incremental checker guarantees whether a design result is consistent with the current state of the underlying conceptual knowledge (data base).}, subject = {CAD}, language = {de} } @inproceedings{KraftNagl2003, author = {Kraft, Bodo and Nagl, Manfred}, title = {Semantic tool support for conceptual design}, year = {2003}, abstract = {ITCE-2003 - 4th Joint Symposium on Information Technology in Civil Engineering ed Flood, I., Seite 1-12, ASCE (CD-ROM), Nashville, USA In this paper we discussed graph based tools to support architects during the conceptual design phase. Conceptual Design is defined before constructive design; the used concepts are more abstract. We develop two graph based approaches, a topdown using the graph rewriting system PROGRES and a more industrially oriented approach, where we extend the CAD system ArchiCAD. In both approaches, knowledge can be defined by a knowledge engineer, in the top-down approach in the domain model graph, in the bottom-up approach in the in an XML file. The defined knowledge is used to incrementally check the sketch and to inform the architect about violations of the defined knowledge. Our goal is to discover design error as soon as possible and to support the architect to design buildings with consideration of conceptual knowledge.}, subject = {CAD}, language = {en} } @inproceedings{KraftRetkowitz2005, author = {Kraft, Bodo and Retkowitz, Daniel}, title = {Operationale Semantikdefinition f{\"u}r konzeptuelles Regelwissen}, year = {2005}, abstract = {In: Forum Bauinformatik 2005 : junge Wissenschaftler forschen / [Lehrstuhl Bauinformatik, Brandenburgische Technische Universit{\"a}t Cottbus. Frank Schley ... (Hrsg.)]. - Cottbus : Techn. Universit{\"a}t 2005. S. 1-10 ISBN 3-934934-11-0 Mittels eines operationalen Ansatzes zur Semantikdefinition wird am Bei-spiel des konzeptuellen Geb{\"a}udeentwurfs ein Regelsystem formalisiert. Dazu werdenzwei Teile, zum einen das Regelwissen, zum anderen ein konzeptueller Entwurfsplan zun{\"a}chst informell eingef{\"u}hrt und dann formal beschrieben. Darauf aufbauend wird die Grundlage f{\"u}r eine Konsistenzpr{\"u}fung des konzeptuellen Entwurfs gegen das Regel-wissen formal angeben}, subject = {CAD}, language = {de} } @inproceedings{KraftRetkowitz2006, author = {Kraft, Bodo and Retkowitz, Daniel}, title = {Graph Transformations for Dynamic Knowledge Processing}, year = {2006}, abstract = {In: Proceedings of the 39th Annual Hawaii International Conference on System Sciences, 2006. HICSS '06 http://dx.doi.org/10.1109/HICSS.2006.200 The conceptual design phase at the beginning of the building construction process is not adequately supported by any CAD-tool. Conceptual design support needs regarding two aspects: first, the architect must be able to develop conceptual sketches that provide abstraction from constructive details. Second, conceptually relevant knowledge should be available to check these conceptual sketches. The paper deals with knowledge to formalize for conceptual design. To enable domain experts formalizing knowledge, a graph-based specification is presented that allows the development of a domain ontology and design rules specific for one class of buildings at runtime. The provided tool support illustrates the introduced concepts and demonstrates the consistency analysis between knowledge and conceptual design.}, subject = {CAD}, language = {de} } @inproceedings{KraftRetkowitz2006, author = {Kraft, Bodo and Retkowitz, Daniel}, title = {Rule-Dependencies for Visual Knowledge Specification in Conceptual Design}, year = {2006}, abstract = {In: Proc. of the 11th Intl. Conf. on Computing in Civil and Building Engineering (ICCCBE-XI) ed. Hugues Rivard, Montreal, Canada, Seite 1-12, ACSE (CD-ROM), 2006 Currently, the conceptual design phase is not adequately supported by any CAD tool. Neither the support while elaborating conceptual sketches, nor the automatic proof of correctness with respect to effective restrictions is currently provided by any commercial tool. To enable domain experts to store the common as well as their personal domain knowledge, we develop a visual language for knowledge formalization. In this paper, a major extension to the already existing concepts is introduced. The possibility to define rule dependencies extends the expressiveness of the knowledge definition language and contributes to the usability of our approach.}, subject = {CAD}, language = {en} } @inproceedings{KraftSchneider2005, author = {Kraft, Bodo and Schneider, Gerd}, title = {Semantic Roomobjects for Conceptual Design Support : A Knowledge-based Approach}, isbn = {978-1-4020-3460-2}, year = {2005}, abstract = {In: Computer Aided Architectural Design Futures 2005 2005, Part 4, 207-216, DOI: http://dx.doi.org/10.1007/1-4020-3698-1_19 The conceptual design at the beginning of the building construction process is essential for the success of a building project. Even if some CAD tools allow elaborating conceptual sketches, they rather focus on the shape of the building elements and not on their functionality. We introduce semantic roomobjects and roomlinks, by way of example to the CAD tool ArchiCAD. These extensions provide a basis for specifying the organisation and functionality of a building and free architects being forced to directly produce detailed constructive sketches. Furthermore, we introduce consistency analyses of the conceptual sketch, based on an ontology containing conceptual relevant knowledge, specific to one class of buildings.}, subject = {CAD}, language = {en} } @inproceedings{KraftWilhelms2004, author = {Kraft, Bodo and Wilhelms, N.}, title = {Interactive distributed knowledge support for conceptual building design}, isbn = {3-86068-213-X}, year = {2004}, abstract = {In: Net-distributed Co-operation : Xth International Conference on Computing in Civil and Building Engineering, Weimar, June 02 - 04, 2004 ; proceedings / [ed. by Karl Beuke ...] . - Weimar: Bauhaus-Univ. Weimar 2004. - 1. Aufl. . Seite 1-14 ISBN 3-86068-213-X International Conference on Computing in Civil and Building Engineering <10, 2004, Weimar> Summary In our project, we develop new tools for the conceptual design phase. During conceptual design, the coarse functionality and organization of a building is more important than a detailed worked out construction. We identify two roles, first the knowledge engineer who is responsible for knowledge definition and maintenance; second the architect who elaborates the conceptual de-sign. The tool for the knowledge engineer is based on graph technology, it is specified using PROGRES and the UPGRADE framework. The tools for the architect are integrated to the in-dustrial CAD tool ArchiCAD. Consistency between knowledge and conceptual design is en-sured by the constraint checker, another extension to ArchiCAD.}, subject = {CAD}, language = {en} } @inproceedings{KraftWilhelms2005, author = {Kraft, Bodo and Wilhelms, Nils}, title = {Visual Knowledge Specification for Conceptual Design}, year = {2005}, abstract = {Proc. of the 2005 ASCE Intl. Conf. on Computing in Civil Engineering (ICCC 2005) eds. L. Soibelman und F. Pena-Mora, Seite 1-14, ASCE (CD-ROM), Cancun, Mexico, 2005 Current CAD tools are not able to support the fundamental conceptual design phase, and none of them provides consistency analyses of sketches produced by architects. To give architects a greater support at the conceptual design phase, we develop a CAD tool for conceptual design and a knowledge specification tool allowing the definition of conceptually relevant knowledge. The knowledge is specific to one class of buildings and can be reused. Based on a dynamic knowledge model, different types of design rules formalize the knowledge in a graph-based realization. An expressive visual language provides a user-friendly, human readable representation. Finally, consistency analyses enable conceptual designs to be checked against this defined knowledge. In this paper we concentrate on the knowledge specification part of our project.}, subject = {CAD}, language = {en} } @inproceedings{KraftZoell2014, author = {Kraft, Bodo and Z{\"o}ll, Axel}, title = {Von der Langstrecke zum Sprint - Agile Methoden in traditionellen Unternehmen}, series = {Projektmanagement und Vorgehensmodelle 2014 : soziale Aspekte und Standardisierung}, booktitle = {Projektmanagement und Vorgehensmodelle 2014 : soziale Aspekte und Standardisierung}, editor = {Engstler, Martin}, publisher = {Gesellschaft f{\"u}r Informatik}, address = {Bonn}, organization = {FH Aachen, University of Applied Sciences}, isbn = {978-3-88579-630-5}, pages = {35 -- 46}, year = {2014}, language = {de} } @inproceedings{KreutzLoergenGraeweetal.2006, author = {Kreutz, Christian and L{\"o}rgen, J{\"u}rgen and Graewe, Boris and Bargon, Joachim and Yoshida, Mayumi and Freso, Zachary M. and Fr{\`e}chet, Jean M. J.}, title = {High frequency quartz micro balances: a promising path to enhanced sensitivity of gravimetric sensors}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1445}, year = {2006}, abstract = {An array of 50 MHz quartz microbalances (QMBs) coated with a dendronized polymer was used to detect small amounts of volatile organic compounds (VOCs) in the gas phase. The results were compared to those obtained with the commonly used 10 MHz QMBs. The 50 MHz QMBs proved to be a powerful tool for the detection of VOCs in the gas phase; therefore, they represent a promising alternative to the much more delicate surface acoustic wave devices (SAWs).}, subject = {Biosensor}, language = {en} } @inproceedings{KreyerStollenwerkSchoening2013, author = {Kreyer, J{\"o}rg and Stollenwerk, Dominik and Sch{\"o}ning, Michael Josef}, title = {Tagung des Forschernachwuchses der FH Aachen 20. November 2013 / ed.: J. Kreyer, D. Stollenwerk, M. J. Sch{\"o}ning}, publisher = {FH Aachen}, address = {Aachen}, pages = {64 S.}, year = {2013}, language = {de} } @inproceedings{KurulganDemirciLinderDemircietal.2010, author = {Kurulgan Demirci, Eylem and Linder, Peter and Demirci, Taylan and Gierkowski, Jessica R. and Digel, Ilya and Gossmann, Matthias and Temiz Artmann, Ayseg{\"u}l}, title = {rhAPC reduces the endothelial cell permeability via a decrease of cellular mechanical contractile tensions : [abstract]}, year = {2010}, abstract = {In this study, the CellDrum technology quanitfying cellular mechanical tension on a pico-scale was used to investigate the effect of LPS (lipopolysaccharide) on HAoEC (Human Aortic Endothelial Cell) tension.}, subject = {Endothelzelle}, language = {en} } @article{KuehnHaugnerStaatetal.2004, author = {K{\"u}hn, Raoul-Roman and Haugner, Werner and Staat, Manfred and Sponagel, Stefan}, title = {A Two Phase Mixture Model based on Bone Observation}, year = {2004}, abstract = {An optimization method is developed to describe the mechanical behaviour of the human cancellous bone. The method is based on a mixture theory. A careful observation of the behaviour of the bone material leads to the hypothesis that the bone density is controlled by the principal stress trajectories (Wolff's law). The basic idea of the developed method is the coupling of a scalar value via an eigenvalue problem to the principal stress trajectories. On the one hand this theory will permit a prediction of the reaction of the biological bone structure after the implantation of a prosthesis, on the other hand it may be useful in engineering optimization problems. An analytical example shows its efficiency.}, subject = {Knochen}, language = {en} } @inproceedings{LangWirtzHeitzeretal.1999, author = {Lang, H. and Wirtz, K. and Heitzer, Michael and Staat, Manfred and Oettel, R.}, title = {Zyklische Einspielversuche zur Verifikation von Shakedown-Analysen mittels FEM}, year = {1999}, abstract = {Im Rahmen von Erm{\"u}dungsanalysen ist nachzuweisen, daß die thermisch bedingten fortschreitenden Deformationen begrenzt bleiben. Hierzu ist die Abgrenzung des Shakedown-Bereiches (Einspielen) vom Ratchetting-Bereich (fortschreitende Deformation) von Interesse. Im Rahmen eines EU-gef{\"o}rderten Forschungsvorhabens wurden Experimente mit einem 4-Stab-Modell durchgef{\"u}hrt. Das Experiment bestand aus einem wassergek{\"u}hlten inneren Rohr und drei isolierten und beheizbaren {\"a}ußeren Probest{\"a}ben. Das System wurde durch alternierende Axialkr{\"a}fte, denen alternierende Temperaturen an den {\"a}ußeren St{\"a}ben {\"u}berlagert wurden, belastet. Die Versuchsparameter wurden teilweise nach vorausgegangenen Einspielanalysen gew{\"a}hlt. W{\"a}hrend der Versuchsdurchf{\"u}hrung wurden Temperaturen und Dehnungen zeitabh{\"a}ngig gemessen. Begleitend und nachfolgend zur Versuchsdurchf{\"u}hrung wurden die Belastungen und die daraus resultierenden Beanspruchungen nachvollzogen. Bei dieser inkrementellen elasto-plastischen Analyse mit dem Programm ANSYS wurden unterschiedliche Werkstoffmodelle angesetzt. Die Ergebnisse dieser Simulationsberechnung dienen dazu, die Shakedown-Analysen mittels FE-Methode zu verifizieren.}, subject = {Einspielen }, language = {de} } @inproceedings{LeiMulchandaniChenetal.2006, author = {Lei, Yu and Mulchandani, Priti and Chen, Wilfred and Mulchandani, Ashok}, title = {Biosensor for direct determination of fenitrothion and EPN using recombinant Pseudomonas putida JS444 with surface expressed organophosphorus hydrolase. 1. modified clark oxygen electrode}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1573}, year = {2006}, abstract = {This paper reports a first microbial biosensor for rapid and cost-effective determination of organophosphorus pesticides fenitrothion and EPN. The biosensor consisted of recombinant PNP-degrading/oxidizing bacteria Pseudomonas putida JS444 anchoring and displaying organophosphorus hydrolase (OPH) on its cell surface as biological sensing element and a dissolved oxygen electrode as the transducer. Surfaceexpressed OPH catalyzed the hydrolysis of fenitrothion and EPN to release 3-methyl-4-nitrophenol and p-nitrophenol, respectively, which were oxidized by the enzymatic machinery of Pseudomonas putida JS444 to carbon dioxide while consuming oxygen, which was measured and correlated to the concentration of organophosphates. Under the optimum operating conditions, the biosensor was able to measure as low as 277 ppb of fenitrothion and 1.6 ppm of EPN without interference from phenolic compounds and other commonly used pesticides such as carbamate pesticides, triazine herbicides and organophosphate pesticides without nitrophenyl substituent. The applicability of the biosensor to lake water was also demonstrated.}, subject = {Biosensor}, language = {en} } @article{LeversStaatLaack2011, author = {Levers, A. and Staat, Manfred and Laack, Walter van}, title = {Analyse der Langzeitwirkung der MBST® KernspinResonanzTherapie bei Gonarthrose}, year = {2011}, abstract = {Originalausgabe: Orthop{\"a}dische Praxis Jg. 47. 2011 H. 11; S. 536-543. Mit freundlicher Genehmigung des Verlags Zusammenfassung: Auf der Basis von Patientenabfragen mittels Fragebogen zum Schmerzempfinden und zur Einschr{\"a}nkung bei Aktivit{\"a}ten des allt{\"a}glichen Lebens wird die Langzeitwirkung der MBST® KernspinResonanz-Therapie bei Gonarthrose untersucht. An der Studie nahmen 39 Patienten teil, bei denen die Therapie bis zu vier Jahre zur{\"u}ckliegt. Neben einer Gesamtbetrachtung wird der Erfolg auch in Abh{\"a}ngigkeit von Alter, Geschlecht und sportlicher Aktivit{\"a}t analysiert. Insgesamt weist die Studie auf eine anhaltende Verbesserung des Gesundheitszustands mit zum Teil deutlicher Schmerzlinderung auch noch nach vier Jahren hin, jedoch mit einer leichten Schmerzzunahme gegen Ende des Untersuchungszeitraums von vier Jahren. Eine tendenziell positivere Wirkung bei Frauen, {\"a}lteren Menschen oder auch sportlich nicht-aktiven Patienten l{\"a}sst auf eine m{\"o}gliche Beeinflussung des Erfolgs der Therapie durch ({\"U}ber-)Belastung im Alltag schließen. Ein zus{\"a}tzlich positiver Effekt der Therapie auf die Knochendichte ist ebenfalls denkbar, dies bleibt jedoch offen.}, subject = {Kniegelenkarthrose}, language = {de} } @inproceedings{MansurovZhubanovaDigeletal.2008, author = {Mansurov, Zulkhair and Zhubanova, Azhar A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Savitskaja, Irina S. and Kozhalakova, A. A. and Kistaubaeva, Aida S.}, title = {The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials}, year = {2008}, abstract = {Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it's microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties - ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS.}, subject = {Kohlenstofffaser}, language = {en} } @inproceedings{MirmohseniRostamizadeh2006, author = {Mirmohseni, Abdolreza and Rostamizadeh, Kobra}, title = {Quartz crystal nanobalance in conjunction with principal component analysis for identification of volatile organic compounds}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1434}, year = {2006}, abstract = {Quartz crystal nanobalance (QCN) sensors are considered as powerful masssensitive sensors to determine materials in the sub-nanogram level. In this study, a single piezoelectric quartz crystal nanobalance modified with polystyrene was employed to detect benzene, toluene, ethylbenzene and xylene (BTEX compounds). The frequency shift of the QCN sensor was found to be linear against the BTEX compound concentrations in the range about 1-45 mg l-1. The correlation coefficients for benzene, toluene, ethylbenzene, and xylene were 0.991, 0.9977, 0.9946 and 0.9971, respectively. The principal component analysis was also utilized to process the frequency response data of the single piezoelectric crystal at different times, considering to the different adsorption-desorption dynamics of BTEX compounds. Using principal component analysis, it was found that over 90\% of the data variance could still be explained by use of two principal components (PC1 and PC2). Subsequently, the successful identification of benzene and toluene was possible through the principal component analysis of the transient responses of the polystyrene modified QCN sensor. The results showed that the polystyrene-modified QCN had favorable identification and quantification performances for the BTEX compounds.}, subject = {Biosensor}, language = {en} } @article{MolinnusIkenJohnenetal.2022, author = {Molinnus, Denise and Iken, Heiko and Johnen, Anna Lynn and Richstein, Benjamin and Hellmich, Lena and Poghossian, Arshak and Knoch, Joachim and Sch{\"o}ning, Michael Josef}, title = {Miniaturized pH-Sensitive Field-Effect Capacitors with Ultrathin Ta₂O₅ Films Prepared by Atomic Layer Deposition}, series = {physica status solidi (a) applications and materials science}, volume = {219}, journal = {physica status solidi (a) applications and materials science}, number = {8}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202100660}, pages = {7 Seiten}, year = {2022}, abstract = {Miniaturized electrolyte-insulator-semiconductor capacitors (EISCAPs) with ultrathin gate insulators have been studied in terms of their pH-sensitive sensor characteristics: three different EISCAP systems consisting of Al-p-Si-Ta2O5(5 nm), Al-p-Si-Si3N4(1 or 2 nm)-Ta2O5 (5 nm), and Al-p-Si-SiO2(3.6 nm)-Ta2O5(5 nm) layer structures are characterized in buffer solution with different pH values by means of capacitance-voltage and constant capacitance method. The SiO2 and Si3N4 gate insulators are deposited by rapid thermal oxidation and rapid thermal nitridation, respectively, whereas the Ta2O5 film is prepared by atomic layer deposition. All EISCAP systems have a clear pH response, favoring the stacked gate insulators SiO2-Ta2O5 when considering the overall sensor characteristics, while the Si3N4(1 nm)-Ta2O5 stack delivers the largest accumulation capacitance (due to the lower equivalent oxide thickness) and a higher steepness in the slope of the capacitance-voltage curve among the studied stacked gate insulator systems.}, language = {en} } @article{MolinnusJanusFangetal.2022, author = {Molinnus, Denise and Janus, Kevin Alexander and Fang, Anyelina C. and Drinic, Aleksander and Achtsnicht, Stefan and K{\"o}pf, Marius and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Thick-film carbon electrode deposited onto a biodegradable fibroin substrate for biosensing applications}, series = {Physica status solidi (a)}, volume = {219}, journal = {Physica status solidi (a)}, number = {23}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202200100}, pages = {1 -- 9}, year = {2022}, abstract = {This study addresses a proof-of-concept experiment with a biocompatible screen-printed carbon electrode deposited onto a biocompatible and biodegradable substrate, which is made of fibroin, a protein derived from silk of the Bombyx mori silkworm. To demonstrate the sensor performance, the carbon electrode is functionalized as a glucose biosensor with the enzyme glucose oxidase and encapsulated with a silicone rubber to ensure biocompatibility of the contact wires. The carbon electrode is fabricated by means of thick-film technology including a curing step to solidify the carbon paste. The influence of the curing temperature and curing time on the electrode morphology is analyzed via scanning electron microscopy. The electrochemical characterization of the glucose biosensor is performed by amperometric/voltammetric measurements of different glucose concentrations in phosphate buffer. Herein, systematic studies at applied potentials from 500 to 1200 mV to the carbon working electrode (vs the Ag/AgCl reference electrode) allow to determine the optimal working potential. Additionally, the influence of the curing parameters on the glucose sensitivity is examined over a time period of up to 361 days. The sensor shows a negligible cross-sensitivity toward ascorbic acid, noradrenaline, and adrenaline. The developed biocompatible biosensor is highly promising for future in vivo and epidermal applications.}, language = {en} } @techreport{NaglKraft2004, author = {Nagl, Manfred and Kraft, Bodo}, title = {Graphbasierte Werkzeuge zur Unterst{\"u}tzung des konzeptuellen Geb{\"a}ude-Entwurfs : Bericht {\"u}ber den 2. F{\"o}rderzeitraum des Schwerpunktprogramms : DFG-Schwerpunktprogramm 1103 : Vernetzt-kooperative Planungsprozesse im Konstruktiven Ingenieurbau. - Auch unter dem Titel: Neue Software-Werkzeuge zur Unterst{\"u}tzung des konzeptuellen Geb{\"a}udeentwurfs}, year = {2004}, abstract = {Der konstruktive Entwurf wird in derzeitigen CAD-Systemen gut unterst{\"u}tzt, nicht aber der konzeptuelle Geb{\"a}ude-Entwurf. Dieser abstrahiert von konstruktiven Elementen wie Linie, Wand oder Decke, um auf die Konzepte, d.h. die eigentlichen Funktionen, heraus zu arbeiten. Diese abstraktere, funktionale Sichtweise auf ein Geb{\"a}ude ist w{\"a}hrend der fr{\"u}hen Entwurfsphase essentiell, um Struktur und Organisation des gesamten Geb{\"a}udes zu erfassen. Bereits in dieser Phase muss Fachwissen (z. B. rechtliche, {\"o}konomische und technische Bestimmungen) ber{\"u}cksichtigt werden. Im Rahmen des vorliegenden Projekts werden Software-Werkzeuge integriert in industrielle CAD-Systeme entwickelt, die den konzeptuellen Geb{\"a}ude-Entwurf erm{\"o}glichen und diesen gegen Fachwissen pr{\"u}fen. Das Projekt ist in zwei Teile gegliedert. Im Top-Down-Ansatz werden Datenstrukturen und Methoden zur Strukturierung, Repr{\"a}sentation und Evaluation von geb{\"a}udespezifischem Fachwissen erarbeitet. Dieser Teil baut auf den graphbasierten Werkzeugen PROGRES und UPGRADE des Lehrstuhls auf. Der Bottom-Up-Ansatz ist industriell orientiert und hat zum Ziel, das kommerzielle CAD-System ArchiCAD zu erweitern. Hierbei soll der fr{\"u}he, konzeptuelle Geb{\"a}ude-Entwurf in einem CAD-System erm{\"o}glicht werden. Der Entwurf kann dar{\"u}ber hinaus gegen das definierte Fachwissen gepr{\"u}ft werden. Im Rahmen des graphbasierten Top-Down-Ansatzes wurde zun{\"a}chst eine neue Spezifikationsmethode f{\"u}r die Sprache PROGRES entwickelt. Das PROGRES-System erlaubt die Spezifikation von Werkzeugen in deklarativer Form. {\"U}blicherweise wird dom{\"a}nenspezifisches Fachwissen in der PROGRES-Spezifikation codiert, das daraus generierte visuelle Werkzeug stellt dann die entsprechende Funktionalit{\"a}t zur Verf{\"u}gung. Mit dieser Methode sind am Lehrstuhl f{\"u}r Informatik III Werkzeuge f{\"u}r verschie-dene Anwendungsdom{\"a}nen entstanden. In unserem Fall versetzen wir einen Dom{\"a}nen-Experten, z. B. einen erfahrenen Architekten, in die Lage, Fachwissen zur Laufzeit einzugeben, dieses zu evaluieren, abzu{\"a}ndern oder zu erg{\"a}nzen. Im Rahmen der bisherigen Arbeit wurde dazu eine parametrisierte PROGRES-Spezifikation und zwei darauf aufbauende Werkzeuge entwickelt, welche die dynamische Eingabe von geb{\"a}ude-technisch relevantem Fachwissen erlauben und einen graphbasierten, konzeptuellen Geb{\"a}ude-Entwurf erm{\"o}glichen. In diesem konzeptuellen Geb{\"a}ude-Entwurf wird von Raumgr{\"o}ßen und Positionen abstrahiert, um die funktionale Struktur eines Geb{\"a}udes zu beschreiben. Das Fachwissen kann von einem Architekten visuell definiert werden. Es k{\"o}nnen semantische Einheiten, im einfachsten Fall R{\"a}ume, nach verschiedenen Kriterien kategorisiert und klassifiziert werden. Mit Hilfe von Attributen und Relationen k{\"o}nnen die semantischen Einheiten pr{\"a}ziser beschrieben und in Beziehung zueinander gesetzt werden. Die in PROGRES spezifizierten Konsistenz-Analysen erlauben die Pr{\"u}fung eines graphbasierten konzeptuellen Geb{\"a}ude-Entwurfs gegen das dynamisch eingef{\"u}gte Fachwissen. Im zweiten Teil des Forschungsprojekts, dem Bottom-Up-Ansatz, wird das CAD-System ArchiCAD erweitert, um den integrierten konzeptuellen Geb{\"a}ude-Entwurf zu erm{\"o}glichen. Der Architekt erh{\"a}lt dazu neue Entwurfselemente, die Raumobjekte, welche die relevanten semantischen Einheiten w{\"a}hrend der fr{\"u}hen Entwurfsphase repr{\"a}sentieren. Mit Hilfe der Raumobjekte kann der Architekt in ArchiCAD den Grundriss und das Raumprogramm eines Geb{\"a}udes entwerfen, ohne von konstruktiven Details in seiner Kreativit{\"a}t eingeschr{\"a}nkt zu werden. Die Arbeitsweise mit Raumobjekten entspricht dem informellen konzeptuellen Entwurf auf einer Papierskizze und ist daher f{\"u}r den Architekten intuitiv und einfach zu verwenden. Durch die Integration in ArchiCAD ergibt sich eine weitere Unterst{\"u}tzung: Das im Top-Down-Ansatz spezifizierte Fach-wissen wird verwendet, um den konzeptuellen Geb{\"a}ude-Entwurf des Architekten auf Regelverletzungen zu {\"u}berpr{\"u}fen. Entwurfsfehler werden angezeigt. Zum Abschluss des konzeptuellen Geb{\"a}ude-Entwurfs mit Raumobjekten wird durch ein weiteres neu entwickeltes Werkzeug eine initiale Wandstruktur automatisch erzeugt, die als Grundlage f{\"u}r die folgenden konstruktiven Entwurfsphasen dient. Alle beschriebenen Erwei-terungen sind in ArchiCAD integriert, sie sind f{\"u}r den Architekten daher leicht zu erlernen und einfach zu bedienen.}, subject = {CAD}, language = {de} } @inproceedings{NaetherJuarezEmmerichetal.2006, author = {N{\"a}ther, Niko and Ju{\´a}rez, Leon M. and Emmerich, R{\"u}diger and Berger, J{\"o}rg and Friedrich, Peter and Sch{\"o}ning, Michael Josef}, title = {Detection of hydrogen peroxide (H2O2) at exposed temperatures for industrial processes}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1418}, year = {2006}, abstract = {An H2O2 sensor for the application in industrial sterilisation processes has been developed. Therefore, automated sterilisation equipment at laboratory scale has been constructed using parts from industrial sterilisation facilities. In addition, a software tool has been developed for the control of the sterilisation equipment at laboratory scale. First measurements with the developed sensor set-up as part of the sterilisation equipment have been performed and the sensor has been physically characterised by optical microscopy and SEM.}, subject = {Biosensor}, language = {en} } @inproceedings{O'HerasDigelTemizArtmann2009, author = {O\'Heras, Carlos and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l}, title = {Nanostructured carbon-based column for LPS/protein adsorption : [abstract]}, year = {2009}, abstract = {The absence of a general method for endotoxin removal from liquid interfaces gives an opportunity to find new methods and materials to overcome this gap. Activated nanostructured carbon is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study is to find the adsorption rates for a carboneous material produced at different temperatures, as well as to reveal possible differences between the performance of the material for each of the adsorbates used during the study (hemoglobin, serum albumin and lipopolysaccharide, LPS).}, subject = {Kohlenstofffaser}, language = {en} } @article{OliveiraMolinnusBegingetal.2021, author = {Oliveira, Danilo A. and Molinnus, Denise and Beging, Stefan and Siqueira Jr, Jos{\´e} R. and Sch{\"o}ning, Michael Josef}, title = {Biosensor Based on Self-Assembled Films of Graphene Oxide and Polyaniline Using a Field-Effect Device Platform}, series = {physica status solidi (a) applications and materials science}, volume = {218}, journal = {physica status solidi (a) applications and materials science}, number = {13}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202000747}, pages = {1 -- 9}, year = {2021}, abstract = {A new functionalization method to modify capacitive electrolyte-insulator-semiconductor (EIS) structures with nanofilms is presented. Layers of polyallylamine hydrochloride (PAH) and graphene oxide (GO) with the compound polyaniline:poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PANI:PAAMPSA) are deposited onto a p-Si/SiO2 chip using the layer-by-layer technique (LbL). Two different enzymes (urease and penicillinase) are separately immobilized on top of a five-bilayer stack of the PAH:GO/PANI:PAAMPSA-modified EIS chip, forming a biosensor for detection of urea and penicillin, respectively. Electrochemical characterization is performed by constant capacitance (ConCap) measurements, and the film morphology is characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). An increase in the average sensitivity of the modified biosensors (EIS-nanofilm-enzyme) of around 15\% is found in relation to sensors, only carrying the enzyme but without the nanofilm (EIS-enzyme). In this sense, the nanofilm acts as a stable bioreceptor onto the EIS chip improving the output signal in terms of sensitivity and stability.}, language = {en} } @inproceedings{PijanowskaRemiszewska2006, author = {Pijanowska, Dorota G. and Remiszewska, Elzbieta}, title = {pH-based detection of phenylalnine by potentiometric and colorimetric methods}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1536}, year = {2006}, abstract = {In this paper, methods of sample preparation for potentiometric measurement of phenylalanine are presented. Basing on the spectrophotometric measurements of phenylalanine, the concentrations of reagents of the enzymatic reaction (10 mM L-Phe, 0,4 mM NAD+, 2U L-PheDH) were determined. Then, the absorption spectrum of the reaction product, NADH, was monitored (maximum peak at 340 nm). The results obtained by the spectrophotometric method were compared with the results obtained by the colourimetry, using pH indicators. The above-mentioned two methods will be used as references for potentiometric measurements of phenylalanine concentration.}, subject = {Biosensor}, language = {en} } @inproceedings{PijanowskaRemiszewskaPederzollietal.2006, author = {Pijanowska, Dorota G. and Remiszewska, Elzbieta and Pederzolli, Cecilia and Lunelli, Lorenzo and Vendano, Michele and Canteri, Roberto and Dudzinski, Konrad and Kruk, Jerzy and Torbicz, Wladyslaw}, title = {Surface modification for microreactor fabrication}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1480}, year = {2006}, abstract = {In this paper, methods of surface modification of different supports, i.e. glass and polymeric beads for enzyme immobilisation are described. The developed method of enzyme immobilisation is based on Schiff's base formation between the amino groups on the enzyme surface and the aldehyde groups on the chemically modified surface of the supports. The surface of silicon modified by APTS and GOPS with immobilised enzyme was characterised by atomic force microscopy (AFM), time-of-flight secondary ion mass spectroscopy (ToF-SIMS) and infrared spectroscopy (FTIR). The supports with immobilised enzyme (urease) were also tested in combination with microreactors fabricated in silicon and Perspex, operating in a flow-through system. For microreactors filled with urease immobilised on glass beads (Sigma) and on polymeric beads (PAN), a very high and stable signal (pH change) was obtained. The developed method of urease immobilisation can be stated to be very effective.}, subject = {Biosensor}, language = {en} } @inproceedings{PlatenPoghossianSchoening2006, author = {Platen, Johannes and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Microstructured Nanostructures - nanostructuring by means of conventional photolithography and layer-expansion technique}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1477}, year = {2006}, abstract = {A new and simple method for nanostructuring using conventional photolithography and layer expansion or pattern-size reduction technique is presented, which can further be applied for the fabrication of different nanostructures and nano-devices. The method is based on the conversion of a photolithographically patterned metal layer to a metal-oxide mask with improved pattern-size resolution using thermal oxidation. With this technique, the pattern size can be scaled down to several nanometer dimensions. The proposed method is experimentally demonstrated by preparing nanostructures with different configurations and layouts, like circles, rectangles, trapezoids, "fluidic-channel"-, "cantilever"- and meander-type structures.}, subject = {Biosensor}, language = {en} } @inproceedings{PoghossianSchumacherKloocketal.2006, author = {Poghossian, Arshak and Schumacher, Kerstin and Kloock, Joachim P. and Rosenkranz, Christian and Schultze, Joachim W. and M{\"u}ller-Veggian, Mattea and Sch{\"o}ning, Michael Josef}, title = {Functional testing and characterisation of ISFETs on wafer level by means of a micro-droplet cell}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1259}, year = {2006}, abstract = {A wafer-level functionality testing and characterisation system for ISFETs (ionsensitive field-effect transistor) is realised by means of integration of a specifically designed capillary electrochemical micro-droplet cell into a commercial wafer prober-station. The developed system allows the identification and selection of "good" ISFETs at the earliest stage and to avoid expensive bonding, encapsulation and packaging processes for nonfunctioning ISFETs and thus, to decrease costs, which are wasted for bad dies. The developed system is also feasible for wafer-level characterisation of ISFETs in terms of sensitivity, hysteresis and response time. Additionally, the system might be also utilised for wafer-level testing of further electrochemical sensors.}, subject = {Biosensor}, language = {en} } @article{PreissLinderWendtetal.2011, author = {Preiß, C. and Linder, Peter and Wendt, K. and Krystek, M. and Digel, Ilya and Gossmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Bassam, Rasha and Artmann, Gerhard}, title = {Engineering technology for plant physiology and plant stress research}, year = {2011}, abstract = {Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.}, subject = {Pflanzenphysiologie}, language = {en} } @inproceedings{RabnerShacham2006, author = {Rabner, Arthur and Shacham, Yosi}, title = {A concept for a sensitive micro total analysis system for high throughput fluorescence imaging}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1456}, year = {2006}, abstract = {This paper discusses possible methods for on-chip fluorescent imaging for integrated bio-sensors. The integration of optical and electro-optical accessories, according to suggested methods, can improve the performance of fluorescence imaging. It can boost the signal to background ratio by a few orders of magnitudes in comparison to conventional discrete setups. The methods that are present in this paper are oriented towards building reproducible arrays for high-throughput micro total analysis systems (µTAS). The first method relates to side illumination of the fluorescent material placed into microcompartments of the lab-on-chip. Its significance is in high utilization of excitation energy for low concentration of fluorescent material. The utilization of a transparent µLED chip, for the second method, allows the placement of the excitation light sources on the same optical axis with emission detector, such that the excitation and emission rays are directed controversly. The third method presents a spatial filtering of the excitation background.}, subject = {Biosensor}, language = {en} } @article{RichterBraunsteinStaeudleetal.2021, author = {Richter, Charlotte and Braunstein, Bjoern and Staeudle, Benjamin and Attias, Julia and Suess, Alexander and Weber, Tobias and Mileva, Katya N. and Rittweger, Joern and Green, David A. and Albracht, Kirsten}, title = {Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity}, series = {npj Microgravity}, volume = {7}, journal = {npj Microgravity}, number = {Article number: 32}, publisher = {Springer Nature}, address = {New York}, issn = {2373-8065}, doi = {10.1038/s41526-021-00155-7}, pages = {7 Seiten}, year = {2021}, abstract = {Vigorous exercise countermeasures in microgravity can largely attenuate muscular degeneration, albeit the extent of applied loading is key for the extent of muscle wasting. Running on the International Space Station is usually performed with maximum loads of 70\% body weight (0.7 g). However, it has not been investigated how the reduced musculoskeletal loading affects muscle and series elastic element dynamics, and thereby force and power generation. Therefore, this study examined the effects of running on the vertical treadmill facility, a ground-based analog, at simulated 0.7 g on gastrocnemius medialis contractile behavior. The results reveal that fascicle-series elastic element behavior differs between simulated hypogravity and 1 g running. Whilst shorter peak series elastic element lengths at simulated 0.7 g appear to be the result of lower muscular and gravitational forces acting on it, increased fascicle lengths and decreased velocities could not be anticipated, but may inform the development of optimized running training in hypogravity. However, whether the alterations in contractile behavior precipitate musculoskeletal degeneration warrants further study.}, language = {en} } @article{RichterBraunsteinStaeudleetal.2021, author = {Richter, Charlotte and Braunstein, Bj{\"o}rn and St{\"a}udle, Benjamin and Attias, Julia and S{\"u}ss, Alexander and Weber, Tobias and Mileva, Katya N. and Rittweger, J{\"o}rn and Green, David A. and Albracht, Kirsten}, title = {Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities}, series = {Scientific reports}, volume = {11}, journal = {Scientific reports}, number = {Article number: 22555}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-021-00527-9}, pages = {13 Seiten}, year = {2021}, abstract = {The international partnership of space agencies has agreed to proceed forward to the Moon sustainably. Activities on the Lunar surface (0.16 g) will allow crewmembers to advance the exploration skills needed when expanding human presence to Mars (0.38 g). Whilst data from actual hypogravity activities are limited to the Apollo missions, simulation studies have indicated that ground reaction forces, mechanical work, muscle activation, and joint angles decrease with declining gravity level. However, these alterations in locomotion biomechanics do not necessarily scale to the gravity level, the reduction in gastrocnemius medialis activation even appears to level off around 0.2 g, while muscle activation pattern remains similar. Thus, it is difficult to predict whether gastrocnemius medialis contractile behavior during running on Moon will basically be the same as on Mars. Therefore, this study investigated lower limb joint kinematics and gastrocnemius medialis behavior during running at 1 g, simulated Martian gravity, and simulated Lunar gravity on the vertical treadmill facility. The results indicate that hypogravity-induced alterations in joint kinematics and contractile behavior still persist between simulated running on the Moon and Mars. This contrasts with the concept of a ceiling effect and should be carefully considered when evaluating exercise prescriptions and the transferability of locomotion practiced in Lunar gravity to Martian gravity.}, language = {en} } @article{RoethenbacherCesariDoppleretal.2022, author = {R{\"o}thenbacher, Annika and Cesari, Matteo and Doppler, Christopher E.J. and Okkels, Niels and Willemsen, Nele and Sembowski, Nora and Seger, Aline and Lindner, Marie and Brune, Corinna and Stefani, Ambra and H{\"o}gl, Birgit and Bialonski, Stephan and Borghammer, Per and Fink, Gereon R. and Schober, Martin and Sommerauer, Michael}, title = {RBDtector: an open-source software to detect REM sleep without atonia according to visual scoring criteria}, series = {Scientific Reports}, volume = {12}, journal = {Scientific Reports}, number = {Article number: 20886}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-022-25163-9}, pages = {1 -- 14}, year = {2022}, abstract = {REM sleep without atonia (RSWA) is a key feature for the diagnosis of rapid eye movement (REM) sleep behaviour disorder (RBD). We introduce RBDtector, a novel open-source software to score RSWA according to established SINBAR visual scoring criteria. We assessed muscle activity of the mentalis, flexor digitorum superficialis (FDS), and anterior tibialis (AT) muscles. RSWA was scored manually as tonic, phasic, and any activity by human scorers as well as using RBDtector in 20 subjects. Subsequently, 174 subjects (72 without RBD and 102 with RBD) were analysed with RBDtector to show the algorithm's applicability. We additionally compared RBDtector estimates to a previously published dataset. RBDtector showed robust conformity with human scorings. The highest congruency was achieved for phasic and any activity of the FDS. Combining mentalis any and FDS any, RBDtector identified RBD subjects with 100\% specificity and 96\% sensitivity applying a cut-off of 20.6\%. Comparable performance was obtained without manual artefact removal. RBD subjects also showed muscle bouts of higher amplitude and longer duration. RBDtector provides estimates of tonic, phasic, and any activity comparable to human scorings. RBDtector, which is freely available, can help identify RBD subjects and provides reliable RSWA metrics.}, language = {en} } @inproceedings{SakthivelWeppner2006, author = {Sakthivel, Mariappan and Weppner, Werner}, title = {Response behaviour of a hydrogen sensor based on ionic conducting polymer-metal interfaces prepared by the chemical reduction method}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1399}, year = {2006}, abstract = {A solid-state amperometric hydrogen sensor based on a protonated Nafion membrane and catalytic active electrode operating at room temperature was fabricated and tested. Ionic conducting polymer-metal electrode interfaces were prepared chemically by using the impregnation-reduction method. The polymer membrane was impregnated with tetra-ammine platinum chloride hydrate and the metal ions were subsequently reduced by using either sodium tetrahydroborate or potassium tetrahydroborate. The hydrogen sensing characteristics with air as reference gas is reported. The sensors were capable of detecting hydrogen concentrations from 10 ppm to 10\% in nitrogen. The response time was in the range of 10-30 s and a stable linear current output was observed. The thin Pt films were characterized by XRD, Infrared Spectroscopy, Optical Microscopy, Atomic Force Microscopy, Scanning Electron Microscopy and EDAX.}, subject = {Biosensor}, language = {en} } @misc{Schreiber2016, author = {Schreiber, Marc}, title = {Mit Maximum-Entropie das Parsing nat{\"u}rlicher Sprache erlernen}, publisher = {FH Aachen}, address = {Aachen}, pages = {23 Seiten}, year = {2016}, abstract = {F{\"u}r die Verarbeitung von nat{\"u}rlicher Sprache ist ein wichtiger Zwischenschritt das Parsing, bei dem f{\"u}r S{\"a}tze der nat{\"u}rlichen Sprache Ableitungsb{\"a}ume bestimmt werden. Dieses Verfahren ist vergleichbar zum Parsen formaler Sprachen, wie z. B. das Parsen eines Quelltextes. Die Parsing-Methoden der formalen Sprachen, z. B. Bottom-up-Parser, k{\"o}nnen nicht auf das Parsen der nat{\"u}rlichen Sprache {\"u}bertragen werden, da keine Formalisierung der nat{\"u}rlichen Sprachen existiert [3, 12, 23, 30]. In den ersten Programmen, die nat{\"u}rliche Sprache verarbeiten [32, 41], wurde versucht die nat{\"u}rliche Sprache mit festen Regelmengen zu verarbeiten. Dieser Ansatz stieß jedoch schnell an seine Grenzen, da die Regelmenge nicht vollst{\"a}ndig sowie nicht minimal ist und wegen der ben{\"o}tigten Menge an Regeln schwer zu verwalten ist. Die Korpuslinguistik [22] bot die M{\"o}glichkeit, die Regelmenge durch Supervised-Machine-Learning-Verfahren [2] abzul{\"o}sen. Teil der Korpuslinguistik ist es, große Textkorpora zu erstellen und diese mit sprachlichen Strukturen zu annotieren. Zu diesen Strukturen geh{\"o}ren sowohl die Wortarten als auch die Ableitungsb{\"a}ume der S{\"a}tze. Vorteil dieser Methodik ist es, dass repr{\"a}sentative Daten zur Verf{\"u}gung stehen. Diese Daten werden genutzt, um mit Supervised-Machine-Learning-Verfahren die Gesetzm{\"a}ßigkeiten der nat{\"u}rliche Sprachen zu erlernen. Das Maximum-Entropie-Verfahren ist ein Supervised-Machine-Learning-Verfahren, das genutzt wird, um nat{\"u}rliche Sprache zu erlernen. Ratnaparkhi [25] nutzt Maximum-Entropie, um Ableitungsb{\"a}ume f{\"u}r S{\"a}tze der nat{\"u}rlichen Sprache zu erlernen. Dieses Verfahren macht es m{\"o}glich, die nat{\"u}rliche Sprache (abgebildet als Σ∗) trotz einer fehlenden formalen Grammatik zu parsen.}, language = {de} } @inproceedings{SchreiberKraftZuendorf2017, author = {Schreiber, Marc and Kraft, Bodo and Z{\"u}ndorf, Albert}, title = {Metrics Driven Research Collaboration: Focusing on Common Project Goals Continuously}, series = {39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina}, booktitle = {39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina}, pages = {8 Seiten}, year = {2017}, abstract = {Research collaborations provide opportunities for both practitioners and researchers: practitioners need solutions for difficult business challenges and researchers are looking for hard problems to solve and publish. Nevertheless, research collaborations carry the risk that practitioners focus on quick solutions too much and that researchers tackle theoretical problems, resulting in products which do not fulfill the project requirements. In this paper we introduce an approach extending the ideas of agile and lean software development. It helps practitioners and researchers keep track of their common research collaboration goal: a scientifically enriched software product which fulfills the needs of the practitioner's business model. This approach gives first-class status to application-oriented metrics that measure progress and success of a research collaboration continuously. Those metrics are derived from the collaboration requirements and help to focus on a commonly defined goal. An appropriate tool set evaluates and visualizes those metrics with minimal effort, and all participants will be pushed to focus on their tasks with appropriate effort. Thus project status, challenges and progress are transparent to all research collaboration members at any time.}, language = {en} } @inproceedings{SchoeningAbdelghani2009, author = {Sch{\"o}ning, Michael Josef and Abdelghani, Adnane}, title = {Advancements in Nanotechnology and Microelectronics (ANM '09) <2009, Tunisia>: Proceedings book ; Tunisia, November, 13 \& 14, 2009 / Humboldt Kolleg. Ed. by Michael J. Sch{\"o}ning ; Adnane Abdelghani}, organization = {Humboldt-Kolleg Advancements in Nanotechnology and Microelectronics (ANM '09) <2009, Tunisia>}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-3113}, year = {2009}, abstract = {The ANM'09 multi-disciplinary scientific program includes topics in the fields of "Nanotechnology and Microelectronics" ranging from "Bio/Micro/Nano Materials and Interfacing" aspects, "Chemical and Bio-Sensors", "Magnetic and Superconducting Devices", "MEMS and Microfluidics" over "Theoretical Aspects, Methods and Modelling" up to the important bridging "Academics meet Industry".}, subject = {Nanopartikel}, language = {en} } @inproceedings{SchoeningAbdelghani2012, author = {Sch{\"o}ning, Michael Josef and Abdelghani, Adnane}, title = {Nanoscale Science and Technology (NS\&T'12) : Proceedings Book Humboldt Kolleg <2012, Tunisia> ; Tunisia, 17-19 March, 2012 / ed. by Michael J. Sch{\"o}ning ; Adnane Abdelghani}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-3544}, year = {2012}, abstract = {Proceedings of the 2nd Humboldt Kolleg, Hammamet, Tunisia Organizer: Alexander von Humboldt Stiftung, Germany. pdf 184 p. Welcome Address Dear Participants, Welcome to the 2nd Humboldt Kolleg in "Nanoscale Science and Technology" (NS\&T'12) in Tunisia, sponsored by the "Alexander von Humboldt" foundation. The NS\&T'12 multidisciplinary scientific program includes seven "hot" topics dealing with "Nanoscale Science and Technology" covering basic and application-oriented research as well as industrial (market) aspects: - Molecular Biophyics, Spectroscopy Techniques, Imaging Microscopy - Nanomaterials Synthesis for Medicine and Bio-chemical Sensors - Nanostructures, Semiconductors, Photonics and Nanodevices - New Technologies in Market Industry - Environment, Electro-chemistry, Bio-polymers and Fuel Cells - Nanomaterials, Photovoltaic, Modelling, Quantum Physics - Microelectronics, Sensors Networks and Embedded Systems We are deeply indebted to all members of the Scientific Committee and General Chairs for joint Sessions and to all speakers and chairmen, who have dedicated invaluable time and efforts for the realization of this event. On behalf of the Organizing Committee, we are cordially inviting you to join the conference and hope that your stay will be fruitful, rewarding and enjoyable. Prof. Dr. Michael J. Sch{\"o}ning, Prof. Dr. Adnane Abdelghani}, subject = {Biosensor}, language = {en} } @article{SeifarthSchehlLinderetal.2011, author = {Seifarth, Volker and Schehl, D. and Linder, Peter and Gossmann, Matthias and Digel, Ilya and Artmann, Gerhard and Porst, Dariusz and Preiß, C. and Kayser, Peter and Pack, O. and Temiz Artmann, Ayseg{\"u}l}, title = {Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds}, year = {2011}, abstract = {The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 \%. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.}, subject = {Tissue Engineering}, language = {en} }