@article{Digel2010, author = {Digel, Ilya}, title = {In-situ biological decontamination of an ice melting probe}, year = {2010}, language = {en} } @article{KozhalakovaZhubanovaMansurovetal.2010, author = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell}, series = {Science of Central Asia (2010)}, journal = {Science of Central Asia (2010)}, pages = {50 -- 54}, year = {2010}, language = {en} } @article{KurzLinderTrzewiketal.2010, author = {Kurz, R. and Linder, Peter and Trzewik, J{\"u}rgen and R{\"u}ffer, M. and Artmann, Gerhard and Digel, Ilya and Rothermel, A. and Robitzki, A. and Temiz Artmann, Ayseg{\"u}l}, title = {Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes}, series = {Medical and Biological Engineering and Computing}, volume = {48}, journal = {Medical and Biological Engineering and Computing}, number = {1}, publisher = {Springer Nature}, address = {Cham}, issn = {1741-0444}, doi = {10.1007/s11517-009-0552-y}, pages = {59 -- 65}, year = {2010}, abstract = {The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.}, language = {en} } @article{GarhoferBekBoehmetal.2010, author = {Garhofer, Gerhard and Bek, Toke and Boehm, Andreas G. and Gherghel, Doina and Grundwald, Juan and Jeppesen, Peter and Kergoat, H{\´e}l{\`e}ne and Kotliar, Konstantin and Lanzl, Ines and Lovasik, John V. and Nagel, Edgar and Vilser, Walthard and Orgul, Selim and Schmetterer, Leopold}, title = {Use of the retinal vessel analyzer in ocular blood flow research}, series = {Acta Ophthalmol}, volume = {88}, journal = {Acta Ophthalmol}, number = {7}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1755-3768}, doi = {10.1111/j.1755-3768.2009.01587.x}, pages = {717 -- 722}, year = {2010}, abstract = {The present article describes a standard instrument for the continuous online determination of retinal vessel diameters, the commercially available retinal vessel analyzer. This report is intended to provide informed guidelines for measuring ocular blood flow with this system. The report describes the principles underlying the method and the instruments currently available, and discusses clinical protocol and the specific parameters measured by the system. Unresolved questions and the possible limitations of the technique are also discussed.}, language = {en} } @article{PresslerEsefeldScherretal.2010, author = {Pressler, Axel and Esefeld, Katrin and Scherr, Johannes and Ali, Mohammad and Hanssen, Henner and Kotliar, Konstantin and Lanzl, Ines and Halle, Martin and Kaemmerer, Harald and Schmidt-Trucks{\"a}ss, Arno and Hager, Alfred}, title = {Structural alterations of retinal arterioles in adults late after repair of aortic isthmic coarctation}, series = {The American Journal of Cardiology}, volume = {105}, journal = {The American Journal of Cardiology}, number = {5}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0002-9149}, doi = {10.1016/j.amjcard.2009.10.070}, pages = {740 -- 744}, year = {2010}, abstract = {Patients after coarctation repair still have an increased risk of cardiovascular or cerebrovascular events. This has been explained by the persisting hypertension and alterations in the peripheral vessels. However, involvement of the central vessels such as the retinal arteries is virtually unknown. A total of 34 patients after coarctation repair (22 men and 12 women; 23 to 58 years old, age range 0 to 32 years at surgical repair) and 34 nonhypertensive controls underwent structural and functional retinal vessel analysis. Using structural analysis, the vessel diameters were measured. Using functional analysis, the endothelium-dependent vessel dilation in response to flicker light stimulation was assessed. In the patients after coarctation repair, the retinal arteriolar diameter was significantly reduced compared to that of the controls (median 182 μm, first to third quartile 171 to 197; vs 197 μm, first to third quartile 193 to 206; p <0.001). These findings were independent of the peripheral blood pressure and age at intervention. No differences were found for venules. The functional analysis findings were not different between the patients and controls (maximum dilation 3.5\%, first to third quartile 2.1\% to 4.5\% vs 3.6\%, first to third quartile 2.2\% to 4.3\%; p = 0.81), indicating preserved autoregulative mechanisms. In conclusion, the retinal artery diameter is reduced in patients after coarctation repair, independent of their current blood pressure level and age at intervention. As a structural marker of chronic vessel damage associated with past, current, or future hypertension, retinal arteriolar narrowing has been linked to stroke incidence. These results indicate an involvement of cerebral microcirculation in aortic coarctation, despite timely repair, and might contribute to explain the increased rate of cerebrovascular events in such patients.}, language = {en} } @article{WiescherKotliarNeuhannetal.2010, author = {Wiescher, A. and Kotliar, Konstantin and Neuhann, T. and Lanzl, Ines M.}, title = {Rasch progrediente Visusminderung beider Augen bei einem jungen Patienten}, series = {Der Ophthalmologe}, volume = {105}, journal = {Der Ophthalmologe}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {1433-0423}, doi = {10.1007/s00347-007-1586-x}, pages = {389 -- 392}, year = {2010}, abstract = {Ein 34-j{\"a}hriger m{\"a}nnlicher Patient stellte sich zur Abkl{\"a}rung einer seit dem 9. Lebensjahr bestehenden und im letzten Jahr rasch progredienten Visusminderung beider Augen bei uns vor. Er beschrieb eine subjektiv zunehmende, im Spiegel f{\"u}r ihn selbst sichtbare, weißliche Tr{\"u}bung in der Pupille beidseits und eine starke Blendempfindlichkeit. Nebenbefundlich gab er rezidivierende Konjunktivitiden und morgens verklebte Lider an. Eine Allergie auf Gr{\"a}serpollen und eine Unvertr{\"a}glichkeit auf Alkohol sowie mehrere Lebensmittel seien ebenfalls bekannt. Zus{\"a}tzlich leidet der Patient an stark ausgepr{\"a}gtem atopischem Ekzem. Dieses wurde nie systemisch, sondern nur bei Bedarf mit kortisonhaltiger Salbe therapiert.}, language = {de} } @article{LanzlSeidovaErbenetal.2010, author = {Lanzl, Ines M. and Seidova, Seid-Fatima and Erben, A. and Th{\"u}rmel, K. and Kotliar, Konstantin}, title = {Diffuse stromale Hornhauttr{\"u}bungen und Ver{\"a}nderungen der H{\"a}nde}, series = {Der Ophthalmologe}, volume = {107}, journal = {Der Ophthalmologe}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {1433-0423}, doi = {10.1007/s00347-009-2066-2}, pages = {363 -- 365}, year = {2010}, abstract = {Bilaterale stromale Hornhauttr{\"u}bungen sind f{\"u}r den Augenarzt eine differenzialdiagnostische Herausforderung. Im folgenden Beitrag werden 2 Patieninnen (30 und 36 Jahre) mit unterschiedlich stark ausgepr{\"a}gter stromaler diffuser Hornhauttr{\"u}bung vorgestellt. Patientin 1 war kleinw{\"u}chsig (114 cm) und Patientin 2 normal groß (172 cm). Beide Patientinnen wiesen ver{\"a}nderte Gelenkstrukturen an Hand und Fußgelenken sowie diffuse stromale Hornhauttr{\"u}bungen auf. Des Weiteren lagen eine Mitral- und Aorteninsuffizienz (Patientin 1) bzw. eine Aorteninsuffizienz (Patientin 2) vor. Die stromalen diffusen Hornhauttr{\"u}bungen ließen im Zusammenhang mit den Gelenkver{\"a}nderungen ein Scheie-Syndrom vermuten. Therapeutisch ist bei Patienten mit Visusminderung eine (lamell{\"a}re) Keratoplastik sinnvoll.}, language = {de} } @article{KotliarNagelVilseretal.2010, author = {Kotliar, Konstantin and Nagel, Edgar and Vilser, Walthard and Seidova, Seid-Fatima and Lanzl, Ines}, title = {Microstructural alterations of retinal arterial blood column along the vessel axis in systemic hypertension}, series = {Investigative Ophthalmology \& Visual Science, IOVS}, volume = {51}, journal = {Investigative Ophthalmology \& Visual Science, IOVS}, number = {4}, publisher = {ARVO}, address = {Rockville, Md.}, issn = {0146-0404}, doi = {10.1167/iovs.09-3649}, pages = {2165 -- 2172}, year = {2010}, abstract = {Purpose: Image analysis by the retinal vessel analyzer (RVA) observes retinal vessels in their dynamic state online noninvasively along a chosen vessel segment. It has been found that high-frequency diameter changes in the retinal artery blood column along the vessel increase significantly in anamnestically healthy volunteers with increasing age and in patients with glaucoma during vascular dilation. This study was undertaken to investigate whether longitudinal sections of the retinal artery blood column are altered in systemic hypertension. Methods: Retinal arteries of 15 untreated patients with essential arterial hypertension (age, 50.9 ± 11.9 years) and of 15 age-matched anamnestically healthy volunteers were examined by RVA. After baseline assessment, a monochromatic luminance flicker (530-600 nm; 12.5 Hz; 20 s) was applied to evoke retinal vasodilation. Differences in amplitude and frequency of spatial artery blood column diameter change along segments (longitudinal arterial profiles) of 1 mm in length were measured and analyzed using Fourier transformation. Results: In the control group, average reduced power spectra (ARPS) of longitudinal arterial profiles did not differ when arteries changed from constriction to dilation. In the systemic hypertension group, ARPS during constriction, baseline, and restoration were identical and differed from ARPS during dilation (P < 0.05). Longitudinal arterial profiles in both groups showed significant dissimilitude at baseline and restoration (P < 0.05). Conclusions: The retinal artery blood column demonstrates microstructural alterations in systemic hypertension and is less irregular along the vessel axis during vessel dilation. These microstructural changes may be an indication of alterations in vessel wall rigidity, vascular endothelial function, and smooth muscle cells in this disease, leading to impaired perfusion and regulation.}, language = {en} } @article{LeimenaArtmannDachwaldetal.2010, author = {Leimena, W. and Artmann, Gerhard and Dachwald, Bernd and Temiz Artmann, Ayseg{\"u}l and Gossmann, Matthias and Digel, Ilya}, title = {Feasibility of an in-situ microbial decontamination of an ice-melting probe}, series = {Eurasian Chemico-Technological Journal. 12 (2010), H. 2}, journal = {Eurasian Chemico-Technological Journal. 12 (2010), H. 2}, isbn = {1562-3920}, pages = {145 -- 150}, year = {2010}, language = {en} } @article{BehbahaniMaiBergmannetal.2010, author = {Behbahani, Mehdi and Mai, A. and Bergmann, B. and Waluga, C. and Behr, M. and Tran, L. and Vonderstein, K. and Mottaghy, K.}, title = {Modeling and Numerical Simulation of Blood Damage}, year = {2010}, language = {en} }