@article{SiqueiraMolinnusBegingetal.2014,
  author    = {Siqueira, Jose R. and Molinnus, Denise and Beging, Stefan and Sch{\"o}ning, Michael Josef},
  title     = {Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection},
  series = {Analytical chemistry},
  volume    = {86},
  journal   = {Analytical chemistry},
  number    = {11},
  publisher = {ACS Publications},
  address   = {Columbus},
  issn      = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)},
  doi       = {10.1021/ac500458s},
  pages     = {5370 -- 5375},
  year      = {2014},
  abstract  = {The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor's surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance-voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform.},
  language  = {en}
}
@inproceedings{BuniatyanHuckPoghossianetal.2014,
  author    = {Buniatyan, V. V. and Huck, Christina and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Rustamyan, L. G. and Hovnikyan, H. H.},
  title     = {Equivalent circuit and optimization of impedance characteristics of an electrolyte conductivity sensor},
  series = {Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering},
  volume    = {Iss. 17},
  booktitle = {Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering},
  number    = {No. 1},
  pages     = {69 -- 76},
  year      = {2014},
  language  = {en}
}
@article{KhaydukovaZadorozhnayaKirsanovetal.2014,
  author    = {Khaydukova, M. M. and Zadorozhnaya, O. A. and Kirsanov, D. O. and Iken, Heiko and Rolka, David and Sch{\"o}ning, Michael Josef and Babain, V. A. and Vlasov, Yu. G. and Legin, A. V.},
  title     = {Multivariate processing of atomic-force microscopy images for detection of the response of plasticized polymeric membranes},
  series = {Russian journal of applied chemistry},
  volume    = {87},
  journal   = {Russian journal of applied chemistry},
  number    = {3},
  publisher = {Springer},
  address   = {Dordrecht},
  issn      = {1608-3296 (E-Journal); 1070-4272 (Print)},
  doi       = {10.1134/S1070427214030112},
  pages     = {307 -- 314},
  year      = {2014},
  abstract  = {The possibility of using the atomic-force microscopy as a method for detection of the analytical signal from plasticized polymeric sensor membranes was analyzed. The surfaces of cadmium-selective membranes based on two polymeric matrices were examined. The digital images were processed with multivariate image analysis techniques. A correlation was found between the surface profile of an ion-selective membrane and the concentration of the ion in solution.},
  language  = {en}
}
@article{GuoMiyamotoWagneretal.2014,
  author    = {Guo, Yuanyuan and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution},
  series = {Sensors and actuators B: Chemical},
  volume    = {204},
  journal   = {Sensors and actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-3077 (E-Journal); 0925-4005 (Print)},
  doi       = {10.1016/j.snb.2014.08.016},
  pages     = {659 -- 665},
  year      = {2014},
  abstract  = {As a semiconductor-based electrochemical sensor, the light-addressable potentiometric sensor (LAPS) can realize two dimensional visualization of (bio-)chemical reactions at the sensor surface addressed by localized illumination. Thanks to this imaging capability, various applications in biochemical and biomedical fields are expected, for which the spatial resolution is critically significant. In this study, therefore, the spatial resolution of the LAPS was investigated in detail based on the device simulation. By calculating the spatiotemporal change of the distributions of electrons and holes inside the semiconductor layer in response to a modulated illumination, the photocurrent response as well as the spatial resolution was obtained as a function of various parameters such as the thickness of the Si substrate, the doping concentration, the wavelength and the intensity of illumination. The simulation results verified that both thinning the semiconductor substrate and increasing the doping concentration could improve the spatial resolution, which were in good agreement with known experimental results and theoretical analysis. More importantly, new findings of interests were also obtained. As for the dependence on the wavelength of illumination, it was found that the known dependence was not always the case. When the Si substrate was thick, a longer wavelength resulted in a higher spatial resolution which was known by experiments. When the Si substrate was thin, however, a longer wavelength of light resulted in a lower spatial resolution. This finding was explained as an effect of raised concentration of carriers, which reduced the thickness of the space charge region. The device simulation was found to be helpful to understand the relationship between the spatial resolution and device parameters, to understand the physics behind it, and to optimize the device structure and measurement conditions for realizing higher performance of chemical imaging systems.},
  language  = {en}
}
@phdthesis{Werner2014,
  author    = {Werner, Frederik},
  title     = {Development of light-addressable potentiometric sensor systems and their applications in biotechnological environments},
  pages     = {XI, 149 S.},
  year      = {2014},
  language  = {en}
}
@article{WagnerDollSchoening2014,
  author    = {Wagner, Patrick and Doll, Theodor and Sch{\"o}ning, Michael Josef},
  title     = {Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Sch{\"o}ning (eds.)},
  series = {Physica status solidi (A) : Applications and materials science},
  volume    = {211},
  journal   = {Physica status solidi (A) : Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-396X (E-Book); 1862-6319 (E-Book); 0031-8965 (Print); 1862-6300 (Print)},
  doi       = {10.1002/pssa.201470241},
  pages     = {1339 -- 1339},
  year      = {2014},
  language  = {en}
}
@incollection{PoghossianWeilandSchoening2014,
  author    = {Poghossian, Arshak and Weiland, Maryam and Sch{\"o}ning, Michael Josef},
  title     = {Nanoplate field-effect capacitors: a new transducer structure for multiparameter (bio-)chemical sensing},
  series = {Multisensor system for chemical analysis : materials and sensors},
  booktitle = {Multisensor system for chemical analysis : materials and sensors},
  editor    = {Lvova, Larisa and Kirsanov, Dmitry and di Natale, Corrado and Legin, Audrey},
  edition   = {1},
  publisher = {Jenny Stanford Publishing},
  address   = {Singapore},
  isbn      = {978-981-4411-15-8 ; 978-981-4411-16-5},
  doi       = {10.1201/b15491-11},
  pages     = {333 -- 373},
  year      = {2014},
  abstract  = {An array of electrically isolated nanoplate field-effect silicon-on-insulator (SOI) capacitors as a new transducer structure for multiparameter (bio-)chemical sensing is presented. The proposed approach allows addressable biasing and electrical readout of multiple nanoplate field-effect capacitive (bio-)chemical sensors on the same SOI chip, as well as differential-mode measurements. The realized sensor chip has been applied for pH and penicillin concentration measurements, electrical monitoring of polyelectrolyte multilayer formation, and the label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization and denaturation events.},
  language  = {en}
}
@article{WhiteheadOehlschlaegerAlmajhdietal.2014,
  author    = {Whitehead, Mark and {\"O}hlschl{\"a}ger, Peter and Almajhdi, Fahad N. and Alloza, Leonor and Marz{\´a}bal, Pablo and Meyers, Ann E. and Hitzeroth, Inga I. and Rybicki, Edward P.},
  title     = {Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice},
  series = {BMC cancer},
  journal   = {BMC cancer},
  number    = {14:367},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1471-2407},
  doi       = {10.1186/1471-2407-14-367},
  pages     = {1 -- 15},
  year      = {2014},
  language  = {en}
}
@article{GuoSekiMiyamotoetal.2014,
  author    = {Guo, Yuanyuan and Seki, Kosuke and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution},
  series = {Applied physics express : APEX},
  volume    = {7},
  journal   = {Applied physics express : APEX},
  number    = {6},
  publisher = {IOP},
  address   = {Bristol},
  issn      = {1882-0786 (E-Journa); 1882-0778 (Print)},
  doi       = {10.7567/APEX.7.067301},
  pages     = {067301-4},
  year      = {2014},
  abstract  = {A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) is proposed to achieve a higher spatial resolution of chemical images. The proposed method employs a combined light source that consists of a modulated light probe, which generates the alternating photocurrent signal, and a ring of constant illumination surrounding it. The constant illumination generates a sheath of carriers with increased concentration which suppresses the spread of photocarriers by enhanced recombination. A device simulation was carried out to verify the effect of constant illumination on the spatial resolution, which demonstrated that a higher spatial resolution can be obtained.},
  language  = {en}
}
@article{KueppersSteffenHellmuthetal.2014,
  author    = {K{\"u}ppers, Tobias and Steffen, Victoria and Hellmuth, Hendrik and O'Connell, Timothy and Bongaerts, Johannes and Maurer, Karl-Heinz and Wiechert, Wolfgang},
  title     = {Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer},
  series = {Microbial cell factories},
  volume    = {13},
  journal   = {Microbial cell factories},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1475-2859 (E-Journal)},
  doi       = {10.1186/1475-2859-13-46},
  pages     = {Article No. 46},
  year      = {2014},
  language  = {en}
}