@article{CollPeralesSchulteTiggesRondinoneetal.2022, author = {Coll-Perales, Baldomero and Schulte-Tigges, Joschua and Rondinone, Michele and Gozalvez, Javier and Reke, Michael and Matheis, Dominik and Walter, Thomas}, title = {Prototyping and evaluation of infrastructure-assisted transition of control for cooperative automated vehicles}, series = {IEEE Transactions on Intelligent Transportation Systems}, volume = {23}, journal = {IEEE Transactions on Intelligent Transportation Systems}, number = {7}, publisher = {IEEE}, issn = {1524-9050 (Print)}, doi = {10.1109/TITS.2021.3061085}, pages = {6720 -- 6736}, year = {2022}, abstract = {Automated driving is now possible in diverse road and traffic conditions. However, there are still situations that automated vehicles cannot handle safely and efficiently. In this case, a Transition of Control (ToC) is necessary so that the driver takes control of the driving. Executing a ToC requires the driver to get full situation awareness of the driving environment. If the driver fails to get back the control in a limited time, a Minimum Risk Maneuver (MRM) is executed to bring the vehicle into a safe state (e.g., decelerating to full stop). The execution of ToCs requires some time and can cause traffic disruption and safety risks that increase if several vehicles execute ToCs/MRMs at similar times and in the same area. This study proposes to use novel C-ITS traffic management measures where the infrastructure exploits V2X communications to assist Connected and Automated Vehicles (CAVs) in the execution of ToCs. The infrastructure can suggest a spatial distribution of ToCs, and inform vehicles of the locations where they could execute a safe stop in case of MRM. This paper reports the first field operational tests that validate the feasibility and quantify the benefits of the proposed infrastructure-assisted ToC and MRM management. The paper also presents the CAV and roadside infrastructure prototypes implemented and used in the trials. The conducted field trials demonstrate that infrastructure-assisted traffic management solutions can reduce safety risks and traffic disruptions.}, language = {en} } @inproceedings{SchulteTiggesMatheisRekeetal.2023, author = {Schulte-Tigges, Joschua and Matheis, Dominik and Reke, Michael and Walter, Thomas and Kaszner, Daniel}, title = {Demonstrating a V2X enabled system for transition of control and minimum risk manoeuvre when leaving the operational design domain}, series = {HCII 2023: HCI in Mobility, Transport, and Automotive Systems}, booktitle = {HCII 2023: HCI in Mobility, Transport, and Automotive Systems}, editor = {Kr{\"o}mker, Heidi}, publisher = {Springer}, address = {Cham}, isbn = {978-3-031-35677-3 (Print)}, doi = {10.1007/978-3-031-35678-0_12}, pages = {200 -- 210}, year = {2023}, abstract = {Modern implementations of driver assistance systems are evolving from a pure driver assistance to a independently acting automation system. Still these systems are not covering the full vehicle usage range, also called operational design domain, which require the human driver as fall-back mechanism. Transition of control and potential minimum risk manoeuvres are currently research topics and will bridge the gap until full autonomous vehicles are available. The authors showed in a demonstration that the transition of control mechanisms can be further improved by usage of communication technology. Receiving the incident type and position information by usage of standardised vehicle to everything (V2X) messages can improve the driver safety and comfort level. The connected and automated vehicle's software framework can take this information to plan areas where the driver should take back control by initiating a transition of control which can be followed by a minimum risk manoeuvre in case of an unresponsive driver. This transition of control has been implemented in a test vehicle and was presented to the public during the IEEE IV2022 (IEEE Intelligent Vehicle Symposium) in Aachen, Germany.}, language = {en} } @article{GrajewskiKleefeld2023, author = {Grajewski, Matthias and Kleefeld, Andreas}, title = {Detecting and approximating decision boundaries in low-dimensional spaces}, series = {Numerical Algorithms}, volume = {93}, journal = {Numerical Algorithms}, number = {4}, publisher = {Springer Science+Business Media}, address = {Dordrecht}, issn = {1572-9265}, pages = {35 Seiten}, year = {2023}, abstract = {A method for detecting and approximating fault lines or surfaces, respectively, or decision curves in two and three dimensions with guaranteed accuracy is presented. Reformulated as a classification problem, our method starts from a set of scattered points along with the corresponding classification algorithm to construct a representation of a decision curve by points with prescribed maximal distance to the true decision curve. Hereby, our algorithm ensures that the representing point set covers the decision curve in its entire extent and features local refinement based on the geometric properties of the decision curve. We demonstrate applications of our method to problems related to the detection of faults, to multi-criteria decision aid and, in combination with Kirsch's factorization method, to solving an inverse acoustic scattering problem. In all applications we considered in this work, our method requires significantly less pointwise classifications than previously employed algorithms.}, language = {en} } @article{CheenakulaGriebelMontagetal.2023, author = {Cheenakula, Dheeraja and Griebel, Kai and Montag, David and Gr{\"o}mping, Markus}, title = {Concept development of a mainstream deammonification and comparison with conventional process in terms of energy, performance and economical construction perspectives}, series = {Frontiers in Microbiology}, volume = {14}, journal = {Frontiers in Microbiology}, number = {11155235}, editor = {Huang, Xiaowu}, publisher = {Frontiers}, issn = {1664-302X}, doi = {10.3389/fmicb.2023.1155235}, pages = {1 -- 15}, year = {2023}, abstract = {Deammonification for nitrogen removal in municipal wastewater in temperate and cold climate zones is currently limited to the side stream of municipal wastewater treatment plants (MWWTP). This study developed a conceptual model of a mainstream deammonification plant, designed for 30,000 P.E., considering possible solutions corresponding to the challenging mainstream conditions in Germany. In addition, the energy-saving potential, nitrogen elimination performance and construction-related costs of mainstream deammonification were compared to a conventional plant model, having a single-stage activated sludge process with upstream denitrification. The results revealed that an additional treatment step by combining chemical precipitation and ultra-fine screening is advantageous prior the mainstream deammonification. Hereby chemical oxygen demand (COD) can be reduced by 80\% so that the COD:N ratio can be reduced from 12 to 2.5. Laboratory experiments testing mainstream conditions of temperature (8-20°C), pH (6-9) and COD:N ratio (1-6) showed an achievable volumetric nitrogen removal rate (VNRR) of at least 50 gN/(m3∙d) for various deammonifying sludges from side stream deammonification systems in the state of North Rhine-Westphalia, Germany, where m3 denotes reactor volume. Assuming a retained Norganic content of 0.0035 kgNorg./(P.E.∙d) from the daily loads of N at carbon removal stage and a VNRR of 50 gN/(m3∙d) under mainstream conditions, a resident-specific reactor volume of 0.115 m3/(P.E.) is required for mainstream deammonification. This is in the same order of magnitude as the conventional activated sludge process, i.e., 0.173 m3/(P.E.) for an MWWTP of size class of 4. The conventional plant model yielded a total specific electricity demand of 35 kWh/(P.E.∙a) for the operation of the whole MWWTP and an energy recovery potential of 15.8 kWh/(P.E.∙a) through anaerobic digestion. In contrast, the developed mainstream deammonification model plant would require only a 21.5 kWh/(P.E.∙a) energy demand and result in 24 kWh/(P.E.∙a) energy recovery potential, enabling the mainstream deammonification model plant to be self-sufficient. The retrofitting costs for the implementation of mainstream deammonification in existing conventional MWWTPs are nearly negligible as the existing units like activated sludge reactors, aerators and monitoring technology are reusable. However, the mainstream deammonification must meet the performance requirement of VNRR of about 50 gN/(m3∙d) in this case.}, language = {en} } @article{TrappLammersEngudaretal.2023, author = {Trapp, Svenja and Lammers, Tom and Engudar, Gokce and Hoehr, Cornelia and Denkova, Antonia G. and Paulßen, Elisabeth and de Kruijff, Robin M.}, title = {Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop}, series = {EJNMMI Radiopharmacy and Chemistry}, volume = {2023}, journal = {EJNMMI Radiopharmacy and Chemistry}, number = {8, Article number: 9}, publisher = {Springer Nature}, issn = {2365-421X}, doi = {10.1186/s41181-023-00195-2}, pages = {1 -- 14}, year = {2023}, language = {en} } @inproceedings{UlmerMostafaWollert2022, author = {Ulmer, Jessica and Mostafa, Youssef and Wollert, J{\"o}rg}, title = {Digital Twin Academy: From Zero to Hero through individual learning experiences}, series = {Tagungsband AALE 2022 / Herausgegeben von der Hochschule f{\"u}r Technik, Wirtschaft und Kultur Leipzig}, booktitle = {Tagungsband AALE 2022 / Herausgegeben von der Hochschule f{\"u}r Technik, Wirtschaft und Kultur Leipzig}, isbn = {978-3-910103-00-9}, doi = {10.33968/2022.33}, url = {http://nbn-resolving.de/urn:nbn:de:bsz:l189-qucosa2-776097}, pages = {1 -- 9}, year = {2022}, abstract = {Digital twins are seen as one of the key technologies of Industry 4.0. Although many research groups focus on digital twins and create meaningful outputs, the technology has not yet reached a broad application in the industry. The main reasons for this imbalance are the complexity of the topic, the lack of specialists, and the unawareness of the twin opportunities. The project "Digital Twin Academy" aims to overcome these barriers by focusing on three actions: Building a digital twin community for discussion and exchange, offering multi-stage training for various knowledge levels, and implementing realworld use cases for deeper insights and guidance. In this work, we focus on creating a flexible learning platform that allows the user to select a training path adjusted to personal knowledge and needs. Therefore, a mix of basic and advanced modules is created and expanded by individual feedback options. The usage of personas supports the selection of the appropriate modules.}, language = {en} } @inproceedings{ChavezBermudezCruzCastanonRuchayetal.2022, author = {Chavez Bermudez, Victor Francisco and Cruz Castanon, Victor Fernando and Ruchay, Marco and Wollert, J{\"o}rg}, title = {Rapid prototyping framework for automation applications based on IO-Link}, series = {Tagungsband AALE 2022}, booktitle = {Tagungsband AALE 2022}, editor = {Leipzig, Hochschule f{\"u}r Technik, Wirtschaft und Kultur}, address = {Leipzig}, isbn = {978-3-910103-00-9}, doi = {10.33968/2022.28}, pages = {8 Seiten}, year = {2022}, abstract = {The development of protype applications with sensors and actuators in the automation industry requires tools that are independent of manufacturer, and are flexible enough to be modified or extended for any specific requirements. Currently, developing prototypes with industrial sensors and actuators is not straightforward. First of all, the exchange of information depends on the industrial protocol that these devices have. Second, a specific configuration and installation is done based on the hardware that is used, such as automation controllers or industrial gateways. This means that the development for a specific industrial protocol, highly depends on the hardware and the software that vendors provide. In this work we propose a rapid-prototyping framework based on Arduino to solve this problem. For this project we have focused to work with the IO-Link protocol. The framework consists of an Arduino shield that acts as the physical layer, and a software that implements the IO-Link Master protocol. The main advantage of such framework is that an application with industrial devices can be rapid-prototyped with ease as its vendor independent, open-source and can be ported easily to other Arduino compatible boards. In comparison, a typical approach requires proprietary hardware, is not easy to port to another system and is closed-source.}, language = {en} } @article{ChengWollertChenetal.2023, author = {Cheng, Chi-Tsun and Wollert, J{\"o}rg and Chen, Xi and Fapojuwo, Abraham O.}, title = {Guest Editorial : Circuits and Systems for Industry X.0 Applications}, series = {IEEE Journal on Emerging and Selected Topics in Circuits and Systems}, volume = {13}, journal = {IEEE Journal on Emerging and Selected Topics in Circuits and Systems}, edition = {2}, publisher = {IEEE}, address = {New York}, issn = {2156-3357 (Print)}, doi = {10.1109/JETCAS.2023.3278843}, pages = {457 -- 460}, year = {2023}, language = {en} } @article{KuchlerGuenthnerRibeiroetal.2023, author = {Kuchler, Timon and G{\"u}nthner, Roman and Ribeiro, Andrea and Hausinger, Renate and Streese, Lukas and W{\"o}hnl, Anna and Kesseler, Veronika and Negele, Johanna and Assali, Tarek and Carbajo-Lozoya, Javier and Lech, Maciej and Adorjan, Kristina and Stubbe, Hans Christian and Hanssen, Henner and Kotliar, Konstantin and Haller, Berhard and Heemann, Uwe and Schmaderer, Christoph}, title = {Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation}, volume = {26}, publisher = {Springer Nature}, address = {Dordrecht}, doi = {10.1007/s10456-023-09885-6}, pages = {547 -- 563}, year = {2023}, abstract = {Background Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians. Methods In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204). Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42\% ± 1.77\% vs. 4.64\% ± 2.59\%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5-190.2] vs. 189.1 [179.4-197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8-0.9] vs. 0.88 [0.8-0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = - 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters. Conclusion Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management.}, language = {en} } @unpublished{GreinerJerominSitholeetal.2023, author = {Greiner, Lasse and Jeromin, G{\"u}nter Erich and Sithole, Patience and Petersen, Soenke}, title = {Preprint: Studies on the enzymatic reduction of levulinic acid using Chiralidon-R and Chiralidon-S}, series = {ChemRxiv}, journal = {ChemRxiv}, doi = {10.26434/chemrxiv-2023-jlvcv}, pages = {13 Seiten}, year = {2023}, abstract = {The enzymatic reduction of levulinic acid by the chiral catalysts Chiralidon-R and Chiralidon-S which are commercially available superabsorbed alcohol dehydrogenases is described. The Chiralidon®-R/S reduces the levulinic acid to the (R,S)-4-hydroxy valeric acid and the (R)- or (S)- gamma-valerolactone.}, language = {en} }