@article{JanusAchtsnichtDrinicetal.2023,
  author    = {Janus, Kevin Alexander and Achtsnicht, Stefan and Drinic, Aleksander and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Transient magnesium-based thin-film temperature sensor on a flexible, bioabsorbable substrate for future medical applications},
  series = {Applied Research},
  journal   = {Applied Research},
  number    = {Accepted manuscript},
  publisher = {Wiley-VCH},
  issn      = {2702-4288 (Print)},
  doi       = {10.1002/appl.202300102},
  pages     = {22 Seiten},
  year      = {2023},
  abstract  = {In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin-film magnesium-based meander-like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium-based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue-like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium-based layers. The 3-layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C.},
  language  = {en}
}
@article{JanusAchtsnichtTempeletal.2023,
  author    = {Janus, Kevin Alexander and Achtsnicht, Stefan and Tempel, Laura and Drinic, Aleksaner and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon},
  series = {Physica status solidi : pss. A, Applications and materials science},
  volume    = {220},
  journal   = {Physica status solidi : pss. A, Applications and materials science},
  number    = {22},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300 (Print)},
  doi       = {10.1002/pssa.202300081},
  pages     = {10 Seiten},
  year      = {2023},
  abstract  = {Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5-10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.},
  language  = {en}
}
@article{JildehWagnerSchoening2021,
  author    = {Jildeh, Zaid B. and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef},
  title     = {Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020},
  series = {physica status solidi (a) applications and materials science},
  volume    = {218},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {13},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202000732},
  pages     = {27 Seiten},
  year      = {2021},
  abstract  = {The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.},
  language  = {en}
}
@article{KarschuckSchmidtAchtsnichtetal.2023,
  author    = {Karschuck, Tobias and Schmidt, Stefan and Achtsnicht, Stefan and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Multiplexing system for automated characterization of a capacitive field-effect sensor array},
  series = {Physica Status Solidi A},
  volume    = {220},
  journal   = {Physica Status Solidi A},
  number    = {22},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300 (Print)},
  doi       = {10.1002/pssa.202300265},
  pages     = {7 Seiten},
  year      = {2023},
  abstract  = {In comparison to single-analyte devices, multiplexed systems for a multianalyte detection offer a reduced assay time and sample volume, low cost, and high throughput. Herein, a multiplexing platform for an automated quasi-simultaneous characterization of multiple (up to 16) capacitive field-effect sensors by the capacitive-voltage (C-V) and the constant-capacitance (ConCap) mode is presented. The sensors are mounted in a newly designed multicell arrangement with one common reference electrode and are electrically connected to the impedance analyzer via the base station. A Python script for the automated characterization of the sensors executes the user-defined measurement protocol. The developed multiplexing system is tested for pH measurements and the label-free detection of ligand-stabilized, charged gold nanoparticles.},
  language  = {en}
}
@article{KaulenSchwabedalSchneideretal.2022,
  author    = {Kaulen, Lars and Schwabedal, Justus T. C. and Schneider, Jules and Ritter, Philipp and Bialonski, Stephan},
  title     = {Advanced sleep spindle identification with neural networks},
  series = {Scientific Reports},
  volume    = {12},
  journal   = {Scientific Reports},
  number    = {Article number: 7686},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-022-11210-y},
  pages     = {1 -- 10},
  year      = {2022},
  abstract  = {Sleep spindles are neurophysiological phenomena that appear to be linked to memory formation and other functions of the central nervous system, and that can be observed in electroencephalographic recordings (EEG) during sleep. Manually identified spindle annotations in EEG recordings suffer from substantial intra- and inter-rater variability, even if raters have been highly trained, which reduces the reliability of spindle measures as a research and diagnostic tool. The Massive Online Data Annotation (MODA) project has recently addressed this problem by forming a consensus from multiple such rating experts, thus providing a corpus of spindle annotations of enhanced quality. Based on this dataset, we present a U-Net-type deep neural network model to automatically detect sleep spindles. Our model's performance exceeds that of the state-of-the-art detector and of most experts in the MODA dataset. We observed improved detection accuracy in subjects of all ages, including older individuals whose spindles are particularly challenging to detect reliably. Our results underline the potential of automated methods to do repetitive cumbersome tasks with super-human performance.},
  language  = {en}
}
@article{Kraft2003,
  author    = {Kraft, Bodo},
  title     = {Conceptual design mit ArchiCAD 8 : Forschungsprojekt an der RWTH Aachen},
  year      = {2003},
  abstract  = {Projektbericht in GraphisoftNews - Architektur und Bauen in einer vernetzten Welt 3/2003 4 Seiten},
  subject      = {CAD},
  language  = {de}
}
@article{KraftNagl2007,
  author    = {Kraft, Bodo and Nagl, Manfred},
  title     = {Visual Knowledge Specification for Conceptual Design: Definition and Tool Support},
  year      = {2007},
  abstract  = {In: Advanced Engineering Informatics. Vol 21, Issue 1, 2007, Pages 67-83 http://dx.doi.org/10.1016/j.aei.2006.10.001 eds. J.C. Kunz, I.F.C. Smith and T. Tomiyama, Elsevier, Seite 1-22 Current CAD tools are not able to support the conceptual design phase, and none of them provides a consistency analysis for sketches produced by architects. This phase is fundamental and crucial for the whole design and construction process of a building. To give architects a better support, we developed a CAD tool for conceptual design and a knowledge specification tool. The knowledge is specific to one class of buildings and it can be reused. Based on a dynamic and domain-specific knowledge ontology, different types of design rules formalize this knowledge in a graph-based form. An expressive visual language provides a user-friendly, human readable representation. Finally, a consistency analysis tool enables conceptual designs to be checked against this formal conceptual knowledge. In this article, we concentrate on the knowledge specification part. For that, we introduce the concepts and usage of a novel visual language and describe its semantics. To demonstrate the usability of our approach, two graph-based visual tools for knowledge specification and conceptual design are explained.},
  subject      = {CAD},
  language  = {en}
}
@article{KuehnHaugnerStaatetal.2004,
  author    = {K{\"u}hn, Raoul-Roman and Haugner, Werner and Staat, Manfred and Sponagel, Stefan},
  title     = {A Two Phase Mixture Model based on Bone Observation},
  year      = {2004},
  abstract  = {An optimization method is developed to describe the mechanical behaviour of the human cancellous bone. The method is based on a mixture theory. A careful observation of the behaviour of the bone material leads to the hypothesis that the bone density is controlled by the principal stress trajectories (Wolff's law). The basic idea of the developed method is the coupling of a scalar value via an eigenvalue problem to the principal stress trajectories. On the one hand this theory will permit a prediction of the reaction of the biological bone structure after the implantation of a prosthesis, on the other hand it may be useful in engineering optimization problems. An analytical example shows its efficiency.},
  subject      = {Knochen},
  language  = {en}
}
@article{LeversStaatLaack2011,
  author    = {Levers, A. and Staat, Manfred and Laack, Walter van},
  title     = {Analyse der Langzeitwirkung der MBST® KernspinResonanzTherapie bei Gonarthrose},
  year      = {2011},
  abstract  = {Originalausgabe: Orthop{\"a}dische Praxis Jg. 47. 2011 H. 11; S. 536-543. Mit freundlicher Genehmigung des Verlags Zusammenfassung: Auf der Basis von Patientenabfragen mittels Fragebogen zum Schmerzempfinden und zur Einschr{\"a}nkung bei Aktivit{\"a}ten des allt{\"a}glichen Lebens wird die Langzeitwirkung der MBST® KernspinResonanz-Therapie bei Gonarthrose untersucht. An der Studie nahmen 39 Patienten teil, bei denen die Therapie bis zu vier Jahre zur{\"u}ckliegt. Neben einer Gesamtbetrachtung wird der Erfolg auch in Abh{\"a}ngigkeit von Alter, Geschlecht und sportlicher Aktivit{\"a}t analysiert. Insgesamt weist die Studie auf eine anhaltende Verbesserung des Gesundheitszustands mit zum Teil deutlicher Schmerzlinderung auch noch nach vier Jahren hin, jedoch mit einer leichten Schmerzzunahme gegen Ende des Untersuchungszeitraums von vier Jahren. Eine tendenziell positivere Wirkung bei Frauen, {\"a}lteren Menschen oder auch sportlich nicht-aktiven Patienten l{\"a}sst auf eine m{\"o}gliche Beeinflussung des Erfolgs der Therapie durch ({\"U}ber-)Belastung im Alltag schließen. Ein zus{\"a}tzlich positiver Effekt der Therapie auf die Knochendichte ist ebenfalls denkbar, dies bleibt jedoch offen.},
  subject      = {Kniegelenkarthrose},
  language  = {de}
}
@article{MolinnusIkenJohnenetal.2022,
  author    = {Molinnus, Denise and Iken, Heiko and Johnen, Anna Lynn and Richstein, Benjamin and Hellmich, Lena and Poghossian, Arshak and Knoch, Joachim and Sch{\"o}ning, Michael Josef},
  title     = {Miniaturized pH-Sensitive Field-Effect Capacitors with Ultrathin Ta₂O₅ Films Prepared by Atomic Layer Deposition},
  series = {physica status solidi (a) applications and materials science},
  volume    = {219},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {8},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202100660},
  pages     = {7 Seiten},
  year      = {2022},
  abstract  = {Miniaturized electrolyte-insulator-semiconductor capacitors (EISCAPs) with ultrathin gate insulators have been studied in terms of their pH-sensitive sensor characteristics: three different EISCAP systems consisting of Al-p-Si-Ta2O5(5 nm), Al-p-Si-Si3N4(1 or 2 nm)-Ta2O5 (5 nm), and Al-p-Si-SiO2(3.6 nm)-Ta2O5(5 nm) layer structures are characterized in buffer solution with different pH values by means of capacitance-voltage and constant capacitance method. The SiO2 and Si3N4 gate insulators are deposited by rapid thermal oxidation and rapid thermal nitridation, respectively, whereas the Ta2O5 film is prepared by atomic layer deposition. All EISCAP systems have a clear pH response, favoring the stacked gate insulators SiO2-Ta2O5 when considering the overall sensor characteristics, while the Si3N4(1 nm)-Ta2O5 stack delivers the largest accumulation capacitance (due to the lower equivalent oxide thickness) and a higher steepness in the slope of the capacitance-voltage curve among the studied stacked gate insulator systems.},
  language  = {en}
}
@article{MolinnusJanusFangetal.2022,
  author    = {Molinnus, Denise and Janus, Kevin Alexander and Fang, Anyelina C. and Drinic, Aleksander and Achtsnicht, Stefan and K{\"o}pf, Marius and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Thick-film carbon electrode deposited onto a biodegradable fibroin substrate for biosensing applications},
  series = {Physica status solidi (a)},
  volume    = {219},
  journal   = {Physica status solidi (a)},
  number    = {23},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202200100},
  pages     = {1 -- 9},
  year      = {2022},
  abstract  = {This study addresses a proof-of-concept experiment with a biocompatible screen-printed carbon electrode deposited onto a biocompatible and biodegradable substrate, which is made of fibroin, a protein derived from silk of the Bombyx mori silkworm. To demonstrate the sensor performance, the carbon electrode is functionalized as a glucose biosensor with the enzyme glucose oxidase and encapsulated with a silicone rubber to ensure biocompatibility of the contact wires. The carbon electrode is fabricated by means of thick-film technology including a curing step to solidify the carbon paste. The influence of the curing temperature and curing time on the electrode morphology is analyzed via scanning electron microscopy. The electrochemical characterization of the glucose biosensor is performed by amperometric/voltammetric measurements of different glucose concentrations in phosphate buffer. Herein, systematic studies at applied potentials from 500 to 1200 mV to the carbon working electrode (vs the Ag/AgCl reference electrode) allow to determine the optimal working potential. Additionally, the influence of the curing parameters on the glucose sensitivity is examined over a time period of up to 361 days. The sensor shows a negligible cross-sensitivity toward ascorbic acid, noradrenaline, and adrenaline. The developed biocompatible biosensor is highly promising for future in vivo and epidermal applications.},
  language  = {en}
}
@article{OliveiraMolinnusBegingetal.2021,
  author    = {Oliveira, Danilo A. and Molinnus, Denise and Beging, Stefan and Siqueira Jr, Jos{\´e} R. and Sch{\"o}ning, Michael Josef},
  title     = {Biosensor Based on Self-Assembled Films of Graphene Oxide and Polyaniline Using a Field-Effect Device Platform},
  series = {physica status solidi (a) applications and materials science},
  volume    = {218},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {13},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202000747},
  pages     = {1 -- 9},
  year      = {2021},
  abstract  = {A new functionalization method to modify capacitive electrolyte-insulator-semiconductor (EIS) structures with nanofilms is presented. Layers of polyallylamine hydrochloride (PAH) and graphene oxide (GO) with the compound polyaniline:poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PANI:PAAMPSA) are deposited onto a p-Si/SiO2 chip using the layer-by-layer technique (LbL). Two different enzymes (urease and penicillinase) are separately immobilized on top of a five-bilayer stack of the PAH:GO/PANI:PAAMPSA-modified EIS chip, forming a biosensor for detection of urea and penicillin, respectively. Electrochemical characterization is performed by constant capacitance (ConCap) measurements, and the film morphology is characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). An increase in the average sensitivity of the modified biosensors (EIS-nanofilm-enzyme) of around 15\% is found in relation to sensors, only carrying the enzyme but without the nanofilm (EIS-enzyme). In this sense, the nanofilm acts as a stable bioreceptor onto the EIS chip improving the output signal in terms of sensitivity and stability.},
  language  = {en}
}
@article{PreissLinderWendtetal.2011,
  author    = {Preiß, C. and Linder, Peter and Wendt, K. and Krystek, M. and Digel, Ilya and Gossmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Bassam, Rasha and Artmann, Gerhard},
  title     = {Engineering technology for plant physiology and plant stress research},
  year      = {2011},
  abstract  = {Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.},
  subject      = {Pflanzenphysiologie},
  language  = {en}
}
@article{RichterBraunsteinStaeudleetal.2021,
  author    = {Richter, Charlotte and Braunstein, Bjoern and Staeudle, Benjamin and Attias, Julia and Suess, Alexander and Weber, Tobias and Mileva, Katya N. and Rittweger, Joern and Green, David A. and Albracht, Kirsten},
  title     = {Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity},
  series = {npj Microgravity},
  volume    = {7},
  journal   = {npj Microgravity},
  number    = {Article number: 32},
  publisher = {Springer Nature},
  address   = {New York},
  issn      = {2373-8065},
  doi       = {10.1038/s41526-021-00155-7},
  pages     = {7 Seiten},
  year      = {2021},
  abstract  = {Vigorous exercise countermeasures in microgravity can largely attenuate muscular degeneration, albeit the extent of applied loading is key for the extent of muscle wasting. Running on the International Space Station is usually performed with maximum loads of 70\% body weight (0.7 g). However, it has not been investigated how the reduced musculoskeletal loading affects muscle and series elastic element dynamics, and thereby force and power generation. Therefore, this study examined the effects of running on the vertical treadmill facility, a ground-based analog, at simulated 0.7 g on gastrocnemius medialis contractile behavior. The results reveal that fascicle-series elastic element behavior differs between simulated hypogravity and 1 g running. Whilst shorter peak series elastic element lengths at simulated 0.7 g appear to be the result of lower muscular and gravitational forces acting on it, increased fascicle lengths and decreased velocities could not be anticipated, but may inform the development of optimized running training in hypogravity. However, whether the alterations in contractile behavior precipitate musculoskeletal degeneration warrants further study.},
  language  = {en}
}
@article{RichterBraunsteinStaeudleetal.2021,
  author    = {Richter, Charlotte and Braunstein, Bj{\"o}rn and St{\"a}udle, Benjamin and Attias, Julia and S{\"u}ss, Alexander and Weber, Tobias and Mileva, Katya N. and Rittweger, J{\"o}rn and Green, David A. and Albracht, Kirsten},
  title     = {Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities},
  series = {Scientific reports},
  volume    = {11},
  journal   = {Scientific reports},
  number    = {Article number: 22555},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-00527-9},
  pages     = {13 Seiten},
  year      = {2021},
  abstract  = {The international partnership of space agencies has agreed to proceed forward to the Moon sustainably. Activities on the Lunar surface (0.16 g) will allow crewmembers to advance the exploration skills needed when expanding human presence to Mars (0.38 g). Whilst data from actual hypogravity activities are limited to the Apollo missions, simulation studies have indicated that ground reaction forces, mechanical work, muscle activation, and joint angles decrease with declining gravity level. However, these alterations in locomotion biomechanics do not necessarily scale to the gravity level, the reduction in gastrocnemius medialis activation even appears to level off around 0.2 g, while muscle activation pattern remains similar. Thus, it is difficult to predict whether gastrocnemius medialis contractile behavior during running on Moon will basically be the same as on Mars. Therefore, this study investigated lower limb joint kinematics and gastrocnemius medialis behavior during running at 1 g, simulated Martian gravity, and simulated Lunar gravity on the vertical treadmill facility. The results indicate that hypogravity-induced alterations in joint kinematics and contractile behavior still persist between simulated running on the Moon and Mars. This contrasts with the concept of a ceiling effect and should be carefully considered when evaluating exercise prescriptions and the transferability of locomotion practiced in Lunar gravity to Martian gravity.},
  language  = {en}
}
@article{RoethenbacherCesariDoppleretal.2022,
  author    = {R{\"o}thenbacher, Annika and Cesari, Matteo and Doppler, Christopher E.J. and Okkels, Niels and Willemsen, Nele and Sembowski, Nora and Seger, Aline and Lindner, Marie and Brune, Corinna and Stefani, Ambra and H{\"o}gl, Birgit and Bialonski, Stephan and Borghammer, Per and Fink, Gereon R. and Schober, Martin and Sommerauer, Michael},
  title     = {RBDtector: an open-source software to detect REM sleep without atonia according to visual scoring criteria},
  series = {Scientific Reports},
  volume    = {12},
  journal   = {Scientific Reports},
  number    = {Article number: 20886},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-022-25163-9},
  pages     = {1 -- 14},
  year      = {2022},
  abstract  = {REM sleep without atonia (RSWA) is a key feature for the diagnosis of rapid eye movement (REM) sleep behaviour disorder (RBD). We introduce RBDtector, a novel open-source software to score RSWA according to established SINBAR visual scoring criteria. We assessed muscle activity of the mentalis, flexor digitorum superficialis (FDS), and anterior tibialis (AT) muscles. RSWA was scored manually as tonic, phasic, and any activity by human scorers as well as using RBDtector in 20 subjects. Subsequently, 174 subjects (72 without RBD and 102 with RBD) were analysed with RBDtector to show the algorithm's applicability. We additionally compared RBDtector estimates to a previously published dataset. RBDtector showed robust conformity with human scorings. The highest congruency was achieved for phasic and any activity of the FDS. Combining mentalis any and FDS any, RBDtector identified RBD subjects with 100\% specificity and 96\% sensitivity applying a cut-off of 20.6\%. Comparable performance was obtained without manual artefact removal. RBD subjects also showed muscle bouts of higher amplitude and longer duration. RBDtector provides estimates of tonic, phasic, and any activity comparable to human scorings. RBDtector, which is freely available, can help identify RBD subjects and provides reliable RSWA metrics.},
  language  = {en}
}
@article{SeifarthSchehlLinderetal.2011,
  author    = {Seifarth, Volker and Schehl, D. and Linder, Peter and Gossmann, Matthias and Digel, Ilya and Artmann, Gerhard and Porst, Dariusz and Preiß, C. and Kayser, Peter and Pack, O. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds},
  year      = {2011},
  abstract  = {The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 \%. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.},
  subject      = {Tissue Engineering},
  language  = {en}
}
@article{SildatkeKarwanniKraftetal.2023,
  author    = {Sildatke, Michael and Karwanni, Hendrik and Kraft, Bodo and Z{\"u}ndorf, Albert},
  title     = {A distributed microservice architecture pattern for the automated generation of information extraction pipelines},
  series = {SN Computer Science},
  journal   = {SN Computer Science},
  number    = {4, Article number: 833},
  publisher = {Springer Singapore},
  address   = {Singapore},
  issn      = {2661-8907},
  doi       = {10.1007/s42979-023-02256-4},
  pages     = {19 Seiten},
  year      = {2023},
  abstract  = {Companies often build their businesses based on product information and therefore try to automate the process of information extraction (IE). Since the information source is usually heterogeneous and non-standardized, classic extract, transform, load techniques reach their limits. Hence, companies must implement the newest findings from research to tackle the challenges of process automation. They require a flexible and robust system that is extendable and ensures the optimal processing of the different document types. This paper provides a distributed microservice architecture pattern that enables the automated generation of IE pipelines. Since their optimal design is individual for each input document, the system ensures the ad-hoc generation of pipelines depending on specific document characteristics at runtime. Furthermore, it introduces the automated quality determination of each available pipeline and controls the integration of new microservices based on their impact on the business value. The introduced system enables fast prototyping of the newest approaches from research and supports companies in automating their IE processes. Based on the automated quality determination, it ensures that the generated pipelines always meet defined business requirements when they come into productive use.},
  language  = {en}
}
@article{Staat2004,
  author    = {Staat, Manfred},
  title     = {Plastic collapse analysis of longitudinally flawed pipes and vessels},
  year      = {2004},
  abstract  = {Improved collapse loads of thick-walled, crack containing pipes and vessels are suggested. Very deep cracks have a residual strength which is better modelled by a global limit load. In all burst tests, the ductility of pressure vessel steels was sufficiently high whereby the burst pressure could be predicted by limit analysis with no need to apply fracture mechanics. The relative prognosis error increases however, for long and deep defects due to uncertainties of geometry and strength data.},
  subject      = {Druckbeh{\"a}lter},
  language  = {en}
}
@article{Staat2000,
  author    = {Staat, Manfred},
  title     = {Direct FEM Limit and Shakedown Analysis with Uncertain Data},
  year      = {2000},
  abstract  = {The structural reliability with respect to plastic collapse or to inadaptation is formulated on the basis of the lower bound limit and shakedown theorems. A direct definition of the limit state function is achieved which permits the use of the highly effective first order reliability methods (FORM) is achieved. The theorems are implemented into a general purpose FEM program in a way capable of large-scale analysis. The limit state function and its gradient are obtained from a mathematical optimization problem. This direct approach reduces considerably the necessary knowledge of uncertain technological input data, the computing time, and the numerical error, leading to highly effective and precise reliability analyses.},
  subject      = {Finite-Elemente-Methode},
  language  = {en}
}
@article{Staat2001,
  author    = {Staat, Manfred},
  title     = {Cyclic plastic deformation tests to verify FEM-based shakedown analyses},
  year      = {2001},
  abstract  = {Fatigue analyses are conducted with the aim of verifying that thermal ratcheting is limited. To this end it is important to make a clear distintion between the shakedown range and the ratcheting range (continuing deformation). As part of an EU-supported research project, experiments were carried out using a 4-bar model. The experiment comprised a water-cooled internal tube, and three insulated heatable outer test bars. The system was subjected to alternating axial forces, superimposed with alternating temperatures at the outer bars. The test parameters were partly selected on the basis of previous shakedown analyses. During the test, temperatures and strains were measured as a function of time. The loads and the resulting stresses were confirmed on an ongoing basis during performance of the test, and after it. Different material models were applied for this incremental elasto-plastic analysis using the ANSYS program. The results of the simulation are used to verify the FEM-based shakedown analysis.},
  subject      = {Materialerm{\"u}dung},
  language  = {en}
}
@article{Staat2005,
  author    = {Staat, Manfred},
  title     = {Local and global collapse pressure of longitudinally flawed pipes and cylindrical vessels},
  year      = {2005},
  abstract  = {Limit loads can be calculated with the finite element method (FEM) for any component, defect geometry, and loading. FEM suggests that published long crack limit formulae for axial defects under-estimate the burst pressure for internal surface defects in thick pipes while limit loads are not conservative for deep cracks and for pressure loaded crack-faces. Very deep cracks have a residual strength, which is modelled by a global collapse load. These observations are combined to derive new analytical local and global collapse loads. The global collapse loads are close to FEM limit analyses for all crack dimensions.},
  subject      = {Finite-Elemente-Methode},
  language  = {en}
}
@article{Staat2005,
  author    = {Staat, Manfred},
  title     = {Direct finite element route for design-by-analysis of pressure components},
  year      = {2005},
  abstract  = {In the new European standard for unfired pressure vessels, EN 13445-3, there are two approaches for carrying out a Design-by-Analysis that cover both the stress categorization method (Annex C) and the direct route method (Annex B) for a check against global plastic deformation and against progressive plastic deformation. This paper presents the direct route in the language of limit and shakedown analysis. This approach leads to an optimization problem. Its solution with Finite Element Analysis is demonstrated for mechanical and thermal actions. One observation from the examples is that the so-called 3f (3Sm) criterion fails to be a reliable check against progressive plastic deformation. Precise conditions are given, which greatly restrict the applicability of the 3f criterion.},
  subject      = {Einspielen <Werkstoff>},
  language  = {en}
}
@article{Staat2003,
  author    = {Staat, Manfred},
  title     = {Shakedown and ratchetting under tension-torsion loadings: analysis and experiments},
  year      = {2003},
  abstract  = {Structural design analyses are conducted with the aim of verifying the exclusion of ratchetting. To this end it is important to make a clear distinction between the shakedown range and the ratchetting range. The performed experiment comprised a hollow tension specimen which was subjected to alternating axial forces, superimposed with constant moments. First, a series of uniaxial tests has been carried out in order to calibrate a bounded kinematic hardening rule. The load parameters have been selected on the basis of previous shakedown analyses with the PERMAS code using a kinematic hardening material model. It is shown that this shakedown analysis gives reasonable agreement between the experimental and the numerical results. A linear and a nonlinear kinematic hardening model of two-surface plasticity are compared in material shakedown analysis.},
  subject      = {Einspielen <Werkstoff>},
  language  = {en}
}
@article{Staat2000,
  author    = {Staat, Manfred},
  title     = {Basis Reduction for the Shakedown Problem for Bounded Kinematic Hardening Material},
  year      = {2000},
  abstract  = {Limit and shakedown analysis are effective methods for assessing the load carrying capacity of a given structure. The elasto-plastic behavior of the structure subjected to loads varying in a given load domain is characterized by the shakedown load factor, defined as the maximum factor which satisfies the sufficient conditions stated in the corresponding static shakedown theorem. The finite element dicretization of the problem may lead to very large convex optimization. For the effective solution a basis reduction method has been developed that makes use of the special problem structure for perfectly plastic material. The paper proposes a modified basis reduction method for direct application to the two-surface plasticity model of bounded kinematic hardening material. The considered numerical examples show an enlargement of the load carrying capacity due to bounded hardening.},
  subject      = {Finite-Elemente-Methode},
  language  = {en}
}
@article{Staat2001,
  author    = {Staat, Manfred},
  title     = {LISA - a European project for FEM-based limit and shakedown analysis},
  year      = {2001},
  abstract  = {The load-carrying capacity or the safety against plastic limit states are the central questions in the design of structures and passive components in the apparatus engineering. A precise answer is most simply given by limit and shakedown analysis. These methods can be based on static and kinematic theorems for lower and upper bound analysis. Both may be formulated as optimization problems for finite element discretizations of structures. The problems of large-scale analysis and the extension towards realistic material modelling will be solved in a European research project. Limit and shakedown analyses are briefly demonstrated with illustrative examples.},
  subject      = {Einspielen <Werkstoff>},
  language  = {en}
}
@article{StaatBallmann1988,
  author    = {Staat, Manfred and Ballmann, J.},
  title     = {Computation of impacts on elastic solids by methods of bicharacteristics},
  series = {Computational Mechanics '88 : theory and applications ; proceedings of the International Conference on Computational Engineering Science April 10-14, 1988, Atlanta, GA, USA ; vol. 2},
  journal   = {Computational Mechanics '88 : theory and applications ; proceedings of the International Conference on Computational Engineering Science April 10-14, 1988, Atlanta, GA, USA ; vol. 2},
  pages     = {1719 -- 1722},
  year      = {1988},
  abstract  = {Shock waves, explosions, impacts or cavitation bubble collapses may generate stress waves in solids causing cracks or unexpected dammage due to focussing, physical nonlinearity or interaction with existing cracks. There is a growing interest in wave propagation, which poses many novel problems to experimentalists and theorists.},
  subject      = {Bicharakteristikenverfahren},
  language  = {en}
}
@article{StaatHeitzer1997,
  author    = {Staat, Manfred and Heitzer, M.},
  title     = {Limit and Shakedown Analysis Using a General Purpose Finite Element Code},
  series = {Proceedings of NAFEMS World Congress '97 on Design, Simulation \& Optimisation : reliability \& applicability of computational methods ; Stuttgart, Germany, 9 - 11 April 1997},
  journal   = {Proceedings of NAFEMS World Congress '97 on Design, Simulation \& Optimisation : reliability \& applicability of computational methods ; Stuttgart, Germany, 9 - 11 April 1997},
  publisher = {NAFEMS},
  address   = {Glasgow},
  isbn      = {1-87437-620-4},
  pages     = {522 -- 533},
  year      = {1997},
  language  = {en}
}
@article{VuStaat2004,
  author    = {Vu, Duc-Khoi and Staat, Manfred},
  title     = {An algorithm for shakedown analysis of structure with temperature dependent yield stress},
  year      = {2004},
  abstract  = {This work is an attempt to answer the question: How to use convex programming in shakedown analysis of structures made of materials with temperature-dependent properties. Based on recently established shakedown theorems and formulations, a dual relationship between upper and lower bounds of the shakedown limit load is found, an algorithmfor shakedown analysis is proposed. While the original problem is neither convex nor concave, the algorithm presented here has the advantage of employing convex programming tools.},
  subject      = {Einspielen <Werkstoff>},
  language  = {en}
}
@article{WeldenNagamineKomesuWagneretal.2021,
  author    = {Welden, Rene and Nagamine Komesu, Cindy A. and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment},
  series = {Electrochemical Science Advances},
  volume    = {2},
  journal   = {Electrochemical Science Advances},
  number    = {4},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {2698-5977},
  doi       = {10.1002/elsa.202100131},
  pages     = {1 -- 5},
  year      = {2021},
  abstract  = {Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin.},
  language  = {en}
}
@article{ZhubanovaAknazarovMansurovetal.2010,
  author    = {Zhubanova, Azhar A. and Aknazarov, S. K. and Mansurov, Zulkhair and Digel, Ilya and Kozhalakova, A. A. and Akimbekov, Nuraly S. and O'Heras, Carlos and Tazhibayeva, S. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials},
  year      = {2010},
  abstract  = {Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.},
  subject      = {Kohlenstofffaser},
  language  = {en}
}
@article{ZhubanovaDigelNojimaetal.2007,
  author    = {Zhubanova, Azhar A. and Digel, Ilya and Nojima, H. and Artmann, Gerhard},
  title     = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology},
  year      = {2007},
  abstract  = {The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.},
  subject      = {Clusterion},
  language  = {en}
}
@article{OezsoyluAliaziziWagneretal.2024,
  author    = {{\"O}zsoylu, Dua and Aliazizi, Fereshteh and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Template bacteria-free fabrication of surface imprinted polymer-based biosensor for E. coli detection using photolithographic mimics: Hacking bacterial adhesion},
  series = {Biosensors and Bioelectronics},
  volume    = {261},
  journal   = {Biosensors and Bioelectronics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-4235 (eISSN)},
  doi       = {10.1016/j.bios.2024.116491},
  pages     = {11 Seiten},
  year      = {2024},
  abstract  = {As one class of molecular imprinted polymers (MIPs), surface imprinted polymer (SIP)-based biosensors show great potential in direct whole-bacteria detection. Micro-contact imprinting, that involves stamping the template bacteria immobilized on a substrate into a pre-polymerized polymer matrix, is the most straightforward and prominent method to obtain SIP-based biosensors. However, the major drawbacks of the method arise from the requirement for fresh template bacteria and often non-reproducible bacteria distribution on the stamp substrate. Herein, we developed a positive master stamp containing photolithographic mimics of the template bacteria (E. coli) enabling reproducible fabrication of biomimetic SIP-based biosensors without the need for the "real" bacteria cells. By using atomic force and scanning electron microscopy imaging techniques, respectively, the E. coli-capturing ability of the SIP samples was tested, and compared with non-imprinted polymer (NIP)-based samples and control SIP samples, in which the cavity geometry does not match with E. coli cells. It was revealed that the presence of the biomimetic E. coli imprints with a specifically designed geometry increases the sensor E. coli-capturing ability by an "imprinting factor" of about 3. These findings show the importance of geometry-guided physical recognition in bacterial detection using SIP-based biosensors. In addition, this imprinting strategy was employed to interdigitated electrodes and QCM (quartz crystal microbalance) chips. E. coli detection performance of the sensors was demonstrated with electrochemical impedance spectroscopy (EIS) and QCM measurements with dissipation monitoring technique (QCM-D).},
  language  = {en}
}
@article{OezsoyluKizildagSchoeningetal.2019,
  author    = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Effect of plasma treatment on the sensor properties of a light-addressable potentiometric sensor (LAPS)},
  series = {physica status solidi a : applications and materials sciences},
  volume    = {216},
  journal   = {physica status solidi a : applications and materials sciences},
  number    = {20},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201900259},
  pages     = {8 Seiten},
  year      = {2019},
  abstract  = {A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment.},
  language  = {en}
}