@book{Laack2007, author = {Laack, Walter van}, title = {To perceive the world with logic}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-936624-08-3}, pages = {340 S. : Ill., graph. Darst}, year = {2007}, language = {en} } @article{BaeckerKochEibenetal.2017, author = {B{\"a}cker, Matthias and Koch, Claudia and Eiben, Sabine and Geiger, Fania and Eber, Fabian and Gliemann, Hartmut and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors}, series = {Sensors and Actuators B: Chemical}, volume = {238}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.07.096}, pages = {716 -- 722}, year = {2017}, abstract = {The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.}, language = {en} } @article{HirschfeldLustfeldReisseletal.2010, author = {Hirschfeld, J. A. and Lustfeld, H. and Reißel, Martin and Steffen, B.}, title = {Tomographic diagnostics of current distributions in a fuel cell stack}, series = {International Journal of Energy Research}, volume = {34}, journal = {International Journal of Energy Research}, number = {3}, isbn = {0363-907X}, pages = {284 -- 292}, year = {2010}, language = {en} } @article{RoehlenPilasDahmenetal.2018, author = {R{\"o}hlen, Desiree and Pilas, Johanna and Dahmen, Markus and Keusgen, Michael and Selmer, Thorsten and Sch{\"o}ning, Michael Josef}, title = {Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes}, series = {Frontiers in Chemistry}, journal = {Frontiers in Chemistry}, number = {6}, publisher = {Frontiers}, address = {Lausanne}, doi = {10.3389/fchem.2018.00284}, pages = {Artikel 284}, year = {2018}, abstract = {Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes.}, language = {en} } @article{ArreolaKeusgenSchoening2019, author = {Arreola, Julio and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Toward an immobilization method for spore-based biosensors in oxidative environment}, series = {Electrochimica Acta}, volume = {302}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.electacta.2019.01.148}, pages = {394 -- 401}, year = {2019}, language = {en} } @article{OberlaenderBrommWendeleretal.2015, author = {Oberl{\"a}nder, Jan and Bromm, Alexander and Wendeler, Luisa and Iken, Heiko and Palomar Duran, Marlena and Greeff, Anton and Kirchner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards a biosensor to monitor the sterilisation efficiency of aseptic filling machines}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431900}, pages = {1299 -- 1305}, year = {2015}, abstract = {Sterilisation processes are compulsory in medicine, pharmacy, and food industries to prevent infections of consumers and microbiological contaminations of products. Monitoring the sterilisation by conventional microbiological methods is time- and lab-consuming. To overcome this problem, in this work a novel biosensor has been proposed. The sensor enables a fast method to evaluate sterilisation processes. By means of thin-film technology the sensor's transducer structures in form of IDEs (interdigitated electrodes) have been fabricated on a silicon substrate. Physical characterisation of the developed sensor was done by AFM, SEM, and profilometry. Impedance analyses were conducted for the electrical characterisation. As microbiological layer spores of B. atrophaeus have been immobilised on the sensing structure; spores of this type are a well-known sterilisation test organism. Impedance measurements at a fixed frequency over time were performed to monitor the immobilisation process. A sterilisation process according to aseptic filling machines was applied to demonstrate the sensor functionality. After both, immobilisation and sterilisation, a change in impedance could successfully be detected.}, language = {en} } @article{SchoeningArzdorfMulchandanietal.2003, author = {Sch{\"o}ning, Michael Josef and Arzdorf, M. and Mulchandani, P. and Chen, W. and Mulchandani, A.}, title = {Towards a capacitive enzyme sensor for direct determination of organophosphorus pesticides: Fundamentals studies and aspects of development}, series = {Sensors. 3 (2003), H. 6}, journal = {Sensors. 3 (2003), H. 6}, isbn = {1424-8220}, pages = {119 -- 127}, year = {2003}, language = {en} } @article{MolinnusDrinicIkenetal.2021, author = {Molinnus, Denise and Drinic, Aleksander and Iken, Heiko and Kr{\"o}ger, Nadja and Zinser, Max and Smeets, Ralf and K{\"o}pf, Marius and Kopp, Alexander and Sch{\"o}ning, Michael Josef}, title = {Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk}, series = {Biosensors and Bioelectronics}, volume = {183}, journal = {Biosensors and Bioelectronics}, number = {Art. 113204}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2021.113204}, year = {2021}, language = {en} } @article{ReisertGeisslerFloerkeetal.2011, author = {Reisert, Steffen and Geissler, Hanno and Fl{\"o}rke, Rudolf and N{\"a}ther, Niko and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Towards a multi-sensor system for the evaluation of aseptic processes employing hydrogen peroxide vapour (H2O2)}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1351 -- 1356}, year = {2011}, language = {en} } @inproceedings{BohrnStuetzFleischeretal.2012, author = {Bohrn, U. and St{\"u}tz, E. and Fleischer, M. and Sch{\"o}ning, Michael Josef and Wagner, P.}, title = {Towards a paradigm change - mammalian cells as sensitive biosensor layers for the detection of unexpected toxic substances in air}, series = {Nanoscale Science and Technology (NS\&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012}, booktitle = {Nanoscale Science and Technology (NS\&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012}, editor = {Abdelghani, Adnane and Sch{\"o}ning, Michael Josef}, pages = {44 -- 44}, year = {2012}, language = {en} } @article{GerhardsSkorupaSanderetal.2011, author = {Gerhards, M. and Skorupa, S. and Sander, Volker and Pfeiffer, P. and Belloum, A.}, title = {Towards a security framework for a WS-HumanTask processor}, series = {7th International Conference on Network and Service Management (CNSM), 2011 Paris}, journal = {7th International Conference on Network and Service Management (CNSM), 2011 Paris}, publisher = {IEEE}, address = {New York}, isbn = {978-3-901882-44-9}, pages = {1 -- 5}, year = {2011}, language = {en} } @article{KirchnerOberlaenderSusoetal.2013, author = {Kirchner, Patrick and Oberl{\"a}nder, Jan and Suso, Henri-Pierre and Rysstad, Gunnar and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards a wireless sensor system for real-time H2O2 monitoring in aseptic food processes}, series = {Physica status solidi (a)}, volume = {210}, journal = {Physica status solidi (a)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201200920}, pages = {877 -- 883}, year = {2013}, abstract = {A wireless sensor system based on the industrial ZigBee standard for low-rate wireless networking was developed that enables real-time monitoring of gaseous H2O2 during the package sterilization in aseptic food processes. The sensor system consists of a remote unit connected to a calorimetric gas sensor, which was already established in former works, and an external base unit connected to a laptop computer. The remote unit was built up by an XBee radio frequency (RF) module for data communication and a programmable system-on-chip controller to read out the sensor signal and process the sensor data, whereas the base unit is a second XBee RF module. For the rapid H2O2 detection on various locations inside the package that has to be sterilized, a novel read-out strategy of the calorimetric gas sensor was established, wherein the sensor response is measured within the short sterilization time and correlated with the present H2O2 concentration. In an exemplary measurement application in an aseptic filling machinery, the suitability of the new, wireless sensor system was demonstrated, wherein the influence of the gas velocity on the H2O2 distribution inside a package was determined and verified with microbiological tests.}, language = {en} } @article{PoghossianWernerBuniatyanetal.2017, author = {Poghossian, Arshak and Werner, Frederik and Buniatyan, V. V. and Wagner, Torsten and Miamoto, K. and Yoshinobu, T. and Sch{\"o}ning, Michael Josef}, title = {Towards addressability of light-addressable potentiometric sensors: Shunting effect of non-illuminated region and cross-talk}, series = {Sensor and Actuators B: Chemical}, journal = {Sensor and Actuators B: Chemical}, number = {244}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.01.047}, pages = {1071 -- 1079}, year = {2017}, abstract = {The LAPS (light-addressable potentiometric sensor) platform is one of the most attractive approaches for chemical and biological sensing with many applications ranging from pH and ion/analyte concentration measurements up to cell metabolism detection and chemical imaging. However, although it is generally accepted that LAPS measurements are spatially resolved, the light-addressability feature of LAPS devices has not been discussed in detail so far. In this work, an extended electrical equivalent-circuit model of the LAPS has been presented, which takes into account possible cross-talk effects due to the capacitive coupling of the non-illuminated region. A shunting effect of the non-illuminated area on the measured photocurrent and addressability of LAPS devices has been studied. It has been shown, that the measured photocurrent will be determined not only by the local interfacial potential in the illuminated region but also by possible interfacial potential changes in the non-illuminated region, yielding cross-talk effects. These findings were supported by the experimental investigations of a penicillin-sensitive multi-spot LAPS and a metal-insulator-semiconductor LAPS as model systems.}, language = {en} } @article{BerretzSkorupaSanderetal.2010, author = {Berretz, F. and Skorupa, S. and Sander, Volker and Belloum, A.}, title = {Towards an actor-driven workflow management system for grids}, series = {International Symposium on Collaborative Technologies and Systems (CTS), 2010 : 17 - 21 May 2010, Chicago, Illinois, USA / IEEE}, journal = {International Symposium on Collaborative Technologies and Systems (CTS), 2010 : 17 - 21 May 2010, Chicago, Illinois, USA / IEEE}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {978-1-4244-6619-1}, pages = {611 -- 616}, year = {2010}, language = {en} } @article{MolinnusSorichBartzetal.2016, author = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate}, series = {Sensors and Actuators B: Chemical}, volume = {237}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.06.064}, pages = {190 -- 195}, year = {2016}, abstract = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.}, language = {en} } @article{SchoeningAbouzarIngebrandtetal.2006, author = {Sch{\"o}ning, Michael Josef and Abouzar, Maryam H. and Ingebrandt, Sven and Platen, Johannes and Offenh{\"a}usser, Andreas and Poghossian, Arshak}, title = {Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices}, series = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, journal = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, number = {paper 0915-R05-04}, editor = {Comini, Elisabetta}, isbn = {9781558998711}, pages = {89 -- 94}, year = {2006}, language = {en} } @article{BreuerPilasGuthmannetal.2019, author = {Breuer, Lars and Pilas, Johanna and Guthmann, Eric and Sch{\"o}ning, Michael Josef and Thoelen, Ronald and Wagner, Torsten}, title = {Towards light-addressable flow control: responsive hydrogels with incorporated graphene oxide as laser-driven actuator structures within microfluidic channels}, series = {Sensor and Actuators B: Chemical}, volume = {288}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2019.02.086}, pages = {579 -- 585}, year = {2019}, language = {en} } @incollection{FrotscherStaat2018, author = {Frotscher, Ralf and Staat, Manfred}, title = {Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_10}, pages = {233 -- 250}, year = {2018}, abstract = {Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.}, language = {en} } @article{PoghossianPlatenSchoening2005, author = {Poghossian, Arshak and Platen, J. and Sch{\"o}ning, Michael Josef}, title = {Towards self-aligned nanostructures by means of layerexpansion technique}, series = {Electrochimica Acta. 51 (2005), H. 5}, journal = {Electrochimica Acta. 51 (2005), H. 5}, isbn = {0013-4686}, pages = {838 -- 843}, year = {2005}, language = {en} } @article{BehbahaniBehrNicolaietal.2008, author = {Behbahani, Mehdi and Behr, Marek and Nicolai, Mike and Probst, Markus}, title = {Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM}, series = {NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum J{\"u}lich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot M{\"u}nster; Dietrich Wolf; Manfred Kremer (ed.)}, journal = {NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum J{\"u}lich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot M{\"u}nster; Dietrich Wolf; Manfred Kremer (ed.)}, publisher = {Forschungszentrum}, address = {J{\"u}lich}, isbn = {978-3-9810843-5-1}, pages = {325 -- 332}, year = {2008}, language = {en} } @inproceedings{BurgethKleefeldZhangetal.2022, author = {Burgeth, Bernhard and Kleefeld, Andreas and Zhang, Eugene and Zhang, Yue}, title = {Towards Topological Analysis of Non-symmetric Tensor Fields via Complexification}, series = {Discrete Geometry and Mathematical Morphology}, booktitle = {Discrete Geometry and Mathematical Morphology}, editor = {Baudrier, {\´E}tienne and Naegel, Beno{\^i}t and Kr{\"a}henb{\"u}hl, Adrien and Tajine, Mohamed}, publisher = {Springer}, address = {Cham}, isbn = {978-3-031-19897-7}, doi = {10.1007/978-3-031-19897-7_5}, pages = {48 -- 59}, year = {2022}, abstract = {Fields of asymmetric tensors play an important role in many applications such as medical imaging (diffusion tensor magnetic resonance imaging), physics, and civil engineering (for example Cauchy-Green-deformation tensor, strain tensor with local rotations, etc.). However, such asymmetric tensors are usually symmetrized and then further processed. Using this procedure results in a loss of information. A new method for the processing of asymmetric tensor fields is proposed restricting our attention to tensors of second-order given by a 2x2 array or matrix with real entries. This is achieved by a transformation resulting in Hermitian matrices that have an eigendecomposition similar to symmetric matrices. With this new idea numerical results for real-world data arising from a deformation of an object by external forces are given. It is shown that the asymmetric part indeed contains valuable information.}, language = {en} } @article{GlueckSchoeningLuethetal.1999, author = {Gl{\"u}ck, O. and Sch{\"o}ning, Michael Josef and L{\"u}th, H. and Otto, A. and Emons, H.}, title = {Trace metal determination by dc resistance changes of microstructured thin gold film electrodes}, series = {Electrochimica Acta. 44 (1999), H. 21-22}, journal = {Electrochimica Acta. 44 (1999), H. 21-22}, isbn = {0013-4686}, pages = {3761 -- 3768}, year = {1999}, language = {en} } @article{GlueckSchoeningLuethetal.1997, author = {Gl{\"u}ck, O. and Sch{\"o}ning, Michael Josef and L{\"u}th, H. and Emons, H. and Hanewinkel, C. and Schumacher, D. and Otto, A.}, title = {Trace metal determination with gold microelectrodes fabricated by silicon technology}, series = {Proceedings of the 11th European Conference on Solid-State Transducers / Eurosensors XI, September 21 - 24, 1997, Warsaw, Poland. [Organised by] Warsaw University of Technology. Vol 2.}, journal = {Proceedings of the 11th European Conference on Solid-State Transducers / Eurosensors XI, September 21 - 24, 1997, Warsaw, Poland. [Organised by] Warsaw University of Technology. Vol 2.}, publisher = {Sensor Lab Sp.}, address = {Warsaw}, isbn = {83-908335-0-6}, pages = {615 -- 618}, year = {1997}, language = {en} } @article{GunGutkinLevetal.2011, author = {Gun, Jenny and Gutkin, Vitaly and Lev, Ovadia and Boyen, Hans-Gerd and Saitner, Marc and Wagner, Patrick and Olieslaeger, Marc D´ and Abouzar, Maryam H. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Tracing gold nanoparticle charge by electrolyte-insulator-semiconductor devices}, series = {Journal of Physical Chemistry C. 115 (2011), H. 11}, journal = {Journal of Physical Chemistry C. 115 (2011), H. 11}, publisher = {American Cemical Society}, address = {Washington, DC}, isbn = {1932-7455}, pages = {4439 -- 4445}, year = {2011}, language = {en} } @article{SanderFidlerKlimala2005, author = {Sander, Volker and Fidler, Markus and Klimala, Wojciech}, title = {Traffic shaping in aggregate-based networks: implementation and analysis / Fidler, Markus ; Sander, Volker ; Klimala, Wojciech}, series = {Computer Communications. 28 (2005), H. 3}, journal = {Computer Communications. 28 (2005), H. 3}, isbn = {0140-3664}, pages = {274 -- 286}, year = {2005}, language = {en} } @article{WerkhausenCroninAlbrachtetal.2019, author = {Werkhausen, Amelie and Cronin, Neil J. and Albracht, Kirsten and Paulsen, G{\o}ran and Larsen, Askild V. and Bojsen-M{\o}ller, Jens and Seynnes, Olivier R.}, title = {Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running}, series = {PeerJ}, journal = {PeerJ}, publisher = {Peer}, address = {London}, issn = {21678359}, doi = {10.7717/peerj.6764}, pages = {18 Seiten}, year = {2019}, abstract = {Background During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus. Methods Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics. Results Achilles tendon stiffness increased by 18\% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30\% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training. Discussion These results show that a training-induced increase in Achilles tendon stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running.}, language = {en} } @article{ReisselBitschMawicketal.2002, author = {Reißel, Martin and Bitsch, G. and Mawick, G. and Tokar, G.}, title = {Transient FEM Simulation of a Door Closing Process and Application to Fatigue / Bitsch, G. ; Mawick, G. ; Reißel, M. ; Tokar, G.}, series = {Proceedings of the 20. CAD-FEM Users Meeting, 2002}, journal = {Proceedings of the 20. CAD-FEM Users Meeting, 2002}, pages = {1 -- 8}, year = {2002}, language = {en} } @article{MennickenPeterKaulenetal.2020, author = {Mennicken, Max and Peter, Sophia K. and Kaulen, Corinna and Simon, Ulrich and Karth{\"a}user, Silvia}, title = {Transport through Redox-Active Ru-Terpyridine Complexes Integrated in Single Nanoparticle Devices}, series = {The Journal of Physical Chemistry C}, volume = {124}, journal = {The Journal of Physical Chemistry C}, number = {8}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {1932-7455}, doi = {10.1021/acs.jpcc.9b11716}, pages = {4881 -- 4889}, year = {2020}, abstract = {Transition metal complexes are electrofunctional molecules due to their high conductivity and their intrinsic switching ability involving a metal-to-ligand charge transfer. Here, a method is presented to contact reliably a few to single redox-active Ru-terpyridine complexes in a CMOS compatible nanodevice and preserve their electrical functionality. Using hybrid materials from 14 nm gold nanoparticles (AuNP) and bis-{4′-[4-(mercaptophenyl)-2,2′:6′,2″-terpyridine]}-ruthenium(II) complexes a device size of 30² nm² inclusive nanoelectrodes is achieved. Moreover, this method bears the opportunity for further downscaling. The Ru-complex AuNP devices show symmetric and asymmetric current versus voltage curves with a hysteretic characteristic in two well separated conductance ranges. By theoretical approximations based on the single-channel Landauer model, the charge transport through the formed double-barrier tunnel junction is thoroughly analyzed and its sensibility to the molecule/metal contact is revealed. It can be verified that tunneling transport through the HOMO is the main transport mechanism while decoherent hopping transport is present to a minor extent.}, language = {en} } @inproceedings{BayerHeschelerArtmannetal.2019, author = {Bayer, Robin and Hescheler, J{\"u}rgen and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Treating arterial hypertension in a cell culture well}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {5 -- 6}, year = {2019}, abstract = {Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the "Deutsche Bluthochdruck Liga" this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.}, language = {en} } @article{StreunChavanLameetal.2006, author = {Streun, M. and Chavan, U. and Lame, H. and Parl, C. and M{\"u}ller-Veggian, Mattea and Ziemons, Karl}, title = {Treating the Gain Non-Uniformity of Multi Channel PMTs by Channel-Specific Trigger Levels}, series = {2006 IEEE Nuclear Science Symposium Conference Record, Vol. 2.}, journal = {2006 IEEE Nuclear Science Symposium Conference Record, Vol. 2.}, address = {San Diego, CA}, issn = {1082-3654}, pages = {1301 -- 1304}, year = {2006}, language = {en} } @article{NaetherRolkaPoghossianetal.2005, author = {N{\"a}ther, Niko and Rolka, David and Poghossian, Arshak and Koudelka-Hep, M. and Sch{\"o}ning, Michael Josef}, title = {Two microcell flow-injection analysis (FIA) platforms for capacitive silicon-based field-effect sensors}, series = {Electrochimica Acta. 51 (2005), H. 5}, journal = {Electrochimica Acta. 51 (2005), H. 5}, isbn = {0013-4686}, doi = {10.1016/j.electacta.2005.04.066}, pages = {924 -- 929}, year = {2005}, language = {en} } @article{SchaeferSchollWaagetal.1993, author = {Sch{\"a}fer, Horst and Scholl, S. and Waag, A. and Hommel, D. (u.a.)}, title = {Two-dimensional Shubnikov-de Haas oscillations in modulation-doped CdTe/CdMnTe quantum-well structures}, series = {Applied Physics Letters. 62 (1993), H. 23}, journal = {Applied Physics Letters. 62 (1993), H. 23}, pages = {3010 -- 3012}, year = {1993}, language = {en} } @article{SeynnesBojsenMollerAlbrachtetal.2015, author = {Seynnes, O. R. and Bojsen-Moller, J. and Albracht, Kirsten and Arndt, A. and Cronin, N. J. and Finni, T. and Magnusson, S. P.}, title = {Ultrasound-based testing of tendon mechanical properties: a critical evaluation}, series = {Journal of Applied Physiology}, volume = {118}, journal = {Journal of Applied Physiology}, number = {2}, issn = {8750-7587}, doi = {10.1152/japplphysiol.00849.2014}, pages = {133 -- 141}, year = {2015}, language = {en} } @incollection{TranStaat2015, author = {Tran, Thanh Ngoc and Staat, Manfred}, title = {Uncertainty multimode failure and shakedown analysis of shells}, series = {Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ...}, booktitle = {Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ...}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-12927-3 (print) ; 978-3-319-12928-0 (online)}, doi = {10.1007/978-3-319-12928-0_14}, pages = {279 -- 298}, year = {2015}, abstract = {This paper presents a numerical procedure for reliability analysis of thin plates and shells with respect to plastic collapse or to inadaptation. The procedure involves a deterministic shakedown analysis for each probabilistic iteration, which is based on the upper bound approach and the use of the exact Ilyushin yield surface. Probabilistic shakedown analysis deals with uncertainties originated from the loads, material strength and thickness of the shell. Based on a direct definition of the limit state function, the calculation of the failure probability may be efficiently solved by using the First and Second Order Reliability Methods (FORM and SORM). The problem of reliability of structural systems (series systems) is handled by the application of a special technique which permits to find all the design points corresponding to all the failure modes. Studies show, in this case, that it improves considerably the FORM and SORM results.}, language = {en} } @article{ReisselLustfeldHirschfeldetal.2009, author = {Reißel, Martin and Lustfeld, H. and Hirschfeld, J. and Steffen, B.}, title = {Uniqueness of magnetotomography for fuel cells and fuel cell stacks / Lustfeld, H. ; Hirschfeld, J. ; Reißel, M ; Steffen, B.}, series = {Journal of Physics A: Mathematical and Theoretical. 42 (2009), H. 495205}, journal = {Journal of Physics A: Mathematical and Theoretical. 42 (2009), H. 495205}, isbn = {0022-3689}, pages = {9 S.}, year = {2009}, language = {en} } @article{Stulpe2009, author = {Stulpe, Werner}, title = {Unitary Operator}, series = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, journal = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-70622-9}, pages = {807 -- 809}, year = {2009}, language = {en} } @article{BialonskiWendlerLehnertz2011, author = {Bialonski, Stephan and Wendler, Martin and Lehnertz, Klaus}, title = {Unraveling spurious properties of interaction networks with tailored random networks}, series = {Plos one}, volume = {6}, journal = {Plos one}, number = {8}, publisher = {Plos}, address = {San Francisco}, doi = {10.1371/journal.pone.0022826}, pages = {e22826}, year = {2011}, abstract = {We investigate interaction networks that we derive from multivariate time series with methods frequently employed in diverse scientific fields such as biology, quantitative finance, physics, earth and climate sciences, and the neurosciences. Mimicking experimental situations, we generate time series with finite length and varying frequency content but from independent stochastic processes. Using the correlation coefficient and the maximum cross-correlation, we estimate interdependencies between these time series. With clustering coefficient and average shortest path length, we observe unweighted interaction networks, derived via thresholding the values of interdependence, to possess non-trivial topologies as compared to Erd{\"o}s-R{\´e}nyi networks, which would indicate small-world characteristics. These topologies reflect the mostly unavoidable finiteness of the data, which limits the reliability of typically used estimators of signal interdependence. We propose random networks that are tailored to the way interaction networks are derived from empirical data. Through an exemplary investigation of multichannel electroencephalographic recordings of epileptic seizures - known for their complex spatial and temporal dynamics - we show that such random networks help to distinguish network properties of interdependence structures related to seizure dynamics from those spuriously induced by the applied methods of analysis.}, language = {en} } @article{MuellerVeggianJannsensMasrietal.1976, author = {M{\"u}ller-Veggian, Mattea and Jannsens, R. and Masri, Y. El. and Michel, C.}, title = {Untersuchung der Hochspinzust{\"a}nde in ¹⁷⁸,¹⁸⁰ Os}, series = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)}, journal = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)}, pages = {950}, year = {1976}, language = {en} } @phdthesis{Pham2011, author = {Pham, Phu Tinh}, title = {Upper bound limit and shakedown analysis of elastic-plastic bounded linearly kinematic hardening structures}, publisher = {RWTH Aachen University}, address = {Aachen}, pages = {140 S.}, year = {2011}, language = {en} } @article{TranKreissigVuetal.2008, author = {Tran, Thanh Ngoc and Kreißig, R. and Vu, Duc Khoi and Staat, Manfred}, title = {Upper bound limit and shakedown analysis of shells using the exact Ilyushin yield surface}, series = {Computer \& Structures. 86 (2008)}, journal = {Computer \& Structures. 86 (2008)}, isbn = {0045-7949}, pages = {1683 -- 1695}, year = {2008}, language = {en} } @phdthesis{Seifarth2015, author = {Seifarth, Volker}, title = {Ureteral tissue engineering : development of a bioreactor system and subsequent characterization of the generated biohybrids}, publisher = {Universit{\"a}tsbibliothek Duisburg-Essen}, address = {Duisburg ; Essen}, year = {2015}, language = {en} } @article{DigelAkimbekovTuralievaetal.2013, author = {Digel, Ilya and Akimbekov, Nuraly S. and Turalieva, M. and Mansurov, Z. and Temiz Artmann, Ayseg{\"u}l and Eshibaev, A. and Zhubanova, A.}, title = {Usage of Carbonized Plant Wastes for Purification of Aqueous Solutions}, series = {Journal of Industrial Technology and Engineering}, volume = {2}, journal = {Journal of Industrial Technology and Engineering}, number = {07}, pages = {47 -- 54}, year = {2013}, language = {en} } @incollection{ZhubanovaMansurovDigel2020, author = {Zhubanova, Azhar A. and Mansurov, Zulkhair A. and Digel, Ilya}, title = {Use of Advanced Nanomaterials for Bioremediation of Contaminated Ecosystems}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing}, address = {Singapore}, isbn = {978-981-4800-27-3}, doi = {10.1201/9780429428647-18}, pages = {353 -- 378}, year = {2020}, abstract = {This chapter shows that nanomaterials obtained by high-temperature carbonization of inexpensive plant raw material such as rice husk, grape seeds, and walnut shells can serve as a basis for the production of highly efficient microbial drugs, biodestructors, biosorbents, and biocatalysts, which are promising for the remediation of the ecosystem contaminated with heavy and radioactive metals, oil and oil products. A strong interest in engineering zymology is dictated by the necessity to address the issues of monitoring enzymatic processes, treatment, and diagnosis of a number of common human diseases, environmental pollution, quality control of pharmaceuticals and food. Nanomaterials obtained by high-temperature carbonization of cheap plant raw material such as-rice husks, grape seeds and walnut shells, can serve as a basis for creating of highly effective microbial preparations-biodestructors, biosorbents and biocatalysts, which are promising for the use of contaminated ecosystems, and for restoration of human intestine microecology.}, language = {en} } @article{AkimbekovZhubanovaMansurovetal.2010, author = {Akimbekov, Nuraly S. and Zhubanova, A. A. and Mansurov, Z. A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Use of Carbonized Rise Shell for the local treatment of wounds}, series = {Eurasian ChemTech Journal}, volume = {12}, journal = {Eurasian ChemTech Journal}, number = {2}, publisher = {Institute of Combustion Problems}, address = {Almaty}, issn = {2522-4867}, doi = {10.18321/ectj35}, pages = {133 -- 138}, year = {2010}, abstract = {On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.}, language = {en} } @article{SiqueiraMakiPaulovichetal.2010, author = {Siqueira, Jose R. and Maki, Rafael M. and Paulovich, Fernando V. and Werner, Frederik and Poghossian, Arshak and Oliveira, Maria C. F. de and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor}, series = {Analytical Chemistry (2010)}, journal = {Analytical Chemistry (2010)}, isbn = {0003-2700}, pages = {61 -- 65}, year = {2010}, language = {en} } @article{GarhoferBekBoehmetal.2010, author = {Garhofer, Gerhard and Bek, Toke and Boehm, Andreas G. and Gherghel, Doina and Grundwald, Juan and Jeppesen, Peter and Kergoat, H{\´e}l{\`e}ne and Kotliar, Konstantin and Lanzl, Ines and Lovasik, John V. and Nagel, Edgar and Vilser, Walthard and Orgul, Selim and Schmetterer, Leopold}, title = {Use of the retinal vessel analyzer in ocular blood flow research}, series = {Acta Ophthalmol}, volume = {88}, journal = {Acta Ophthalmol}, number = {7}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1755-3768}, doi = {10.1111/j.1755-3768.2009.01587.x}, pages = {717 -- 722}, year = {2010}, abstract = {The present article describes a standard instrument for the continuous online determination of retinal vessel diameters, the commercially available retinal vessel analyzer. This report is intended to provide informed guidelines for measuring ocular blood flow with this system. The report describes the principles underlying the method and the instruments currently available, and discusses clinical protocol and the specific parameters measured by the system. Unresolved questions and the possible limitations of the technique are also discussed.}, language = {en} } @article{BohrnStuetzFleischeretal.2013, author = {Bohrn, Ulrich and St{\"u}tz, Evamaria and Fleischer, Maximilian and Sch{\"o}ning, Michael Josef and Wagner, Patrick}, title = {Using a cell-based gas biosensor for investigation of adverse effects of acetone vapors in vitro}, series = {Biosensors and Bioelectronics. 40 (2013), H. 1}, journal = {Biosensors and Bioelectronics. 40 (2013), H. 1}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0956-5663}, pages = {393 -- 400}, year = {2013}, language = {en} } @inproceedings{SchreiberBarkschatKraft2014, author = {Schreiber, Marc and Barkschat, Kai and Kraft, Bodo}, title = {Using Continuous Integration to organize and monitor the annotation process of domain specific corpora}, series = {5th International Conference on Information and Communication Systems (ICICS) : 1-3 April 2014, Irbid, Jordanien}, booktitle = {5th International Conference on Information and Communication Systems (ICICS) : 1-3 April 2014, Irbid, Jordanien}, organization = {International Conference on Information and Communication Systems <5, 2014, Irbid, Jordanien>}, isbn = {978-1-4799-3022-7}, doi = {10.1109/IACS.2014.6841958}, pages = {1 -- 6}, year = {2014}, language = {en} } @article{ZangeSchopenAlbrachtetal.2017, author = {Zange, Jochen and Schopen, Kathrin and Albracht, Kirsten and Gerlach, Darius A. and Frings-Meuthen, Petra and Maffiuletti, Nicola A. and Bloch, Wilhelm and Rittweger, J{\"o}rn}, title = {Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial}, series = {Plos one}, volume = {12}, journal = {Plos one}, number = {2}, doi = {10.1371/journal.pone.0171562}, year = {2017}, language = {en} } @article{WagnerMiyamotoWerneretal.2011, author = {Wagner, Torsten and Miyamoto, K. and Werner, Frederik and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS)}, volume = {9}, number = {2}, publisher = {American Scientific Publishers}, address = {Stevenson Ranch, Calif.}, doi = {10.1166/sl.2011.1620}, pages = {812 -- 815}, year = {2011}, language = {en} }