@article{ZhubanovaAknazarovMansurovetal.2010,
  author    = {Zhubanova, Azhar A. and Aknazarov, S. K. and Mansurov, Zulkhair and Digel, Ilya and Kozhalakova, A. A. and Akimbekov, Nuraly S. and O'Heras, Carlos and Tazhibayeva, S. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials},
  year      = {2010},
  abstract  = {Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.},
  subject      = {Kohlenstofffaser},
  language  = {en}
}
@article{ZhubanovaDigelNojimaetal.2007,
  author    = {Zhubanova, Azhar A. and Digel, Ilya and Nojima, H. and Artmann, Gerhard},
  title     = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology},
  year      = {2007},
  abstract  = {The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.},
  subject      = {Clusterion},
  language  = {en}
}
@article{ZhubanovaMansurovDigeletal.2013,
  author    = {Zhubanova, А. and Mansurov, Z.A. and Digel, Ilya and Saviskaya, I.S. and Akimbekov, Nuraly S.},
  title     = {Designing of Heterogeneous Nanobiocomposites for Biotechnology},
  series = {KazNU Bulletin. Biology series},
  volume    = {59},
  journal   = {KazNU Bulletin. Biology series},
  number    = {No 3/1},
  isbn      = {1563-0218},
  pages     = {89 -- 93},
  year      = {2013},
  language  = {ru}
}
@article{Ziemons1991,
  author    = {Ziemons, Karl},
  title     = {Comparison of forward hadrons produced in muon interactions on nuclear targets and deuterium},
  series = {Zeitschrift f{\"u}r Physik C Particles and Fields},
  volume    = {52},
  journal   = {Zeitschrift f{\"u}r Physik C Particles and Fields},
  number    = {1},
  isbn      = {1431-5858},
  pages     = {1 -- 11},
  year      = {1991},
  abstract  = {Differential multiplicities of forward produced hadrons in deep inelastic muon scattering on nuclear targets have been compared with those from deuterium. The ratios are observed to increase towards unity as the virtual photon energy increases with no significant dependence on the other muon kinematic variables. The hadron transverse momentum distribution is observed to be broadened in nuclear targets. The dependence on the remaining hadron variables is investigated and the results are discussed in the framework of intranuclear interaction models and in the context of the EMC effect.},
  language  = {en}
}
@article{Ziemons1992,
  author    = {Ziemons, Karl},
  title     = {Muoproduction of J/ψ and the gluon distribution of the nucleon},
  series = {Zeitschrift f{\"u}r Physik C Particles and Fields},
  volume    = {56},
  journal   = {Zeitschrift f{\"u}r Physik C Particles and Fields},
  number    = {1},
  isbn      = {1431-5858},
  pages     = {21 -- 28},
  year      = {1992},
  abstract  = {Measurements are presented of the inclusive distributions of the J/Ψ meson produced by muons of energy 200 GeV from an ammonia target. The gluon distribution of the nucleon has been derived from the data in the range 0.04<x<0.36 using a technique based on the colour singlet model. An arbitrary normalisation factor is required to obtain a reasonable integral of the gluon distribution. Some comments are made on the use of J/Ψ productionby virtual photons to extract the gluon distribution at HERA.},
  language  = {en}
}
@article{Ziemons1993,
  author    = {Ziemons, Karl},
  title     = {A measurement of the ratio of the nucleon structure function in copper and deuterium},
  series = {Zeitschrift f{\"u}r Physik C Particles and Fields},
  volume    = {57},
  journal   = {Zeitschrift f{\"u}r Physik C Particles and Fields},
  number    = {2},
  isbn      = {1431-5858},
  pages     = {211 -- 218},
  year      = {1993},
  abstract  = {Results are presented on the ratios of the nucleon structure function in copper to deuterium from two separate experiments. The data confirm that the nucleon structure function,F 2, is different for bound nucleons than for the quasi-free ones in the deuteron. The redistribution in the fraction of the nucleon's momentum carried by quarks is investigated and it is found that the data are compatible with no integral loss of quark momenta due to nuclear effects.},
  language  = {en}
}
@article{Ziemons1987,
  author    = {Ziemons, Karl},
  title     = {Jet production and fragmentation properties in deep inelastic muon scattering},
  series = {Zeitschrift f{\"u}r Physik C : Particles and Fields},
  volume    = {36},
  journal   = {Zeitschrift f{\"u}r Physik C : Particles and Fields},
  number    = {4},
  isbn      = {0170-9739},
  pages     = {527 -- 543},
  year      = {1987},
  language  = {en}
}
@article{Ziemons1988,
  author    = {Ziemons, Karl},
  title     = {A measurement of the spin asymmetry of the structure function g1 in deep inelastic muon-proton scattering},
  series = {Physics Letters B},
  volume    = {206},
  journal   = {Physics Letters B},
  number    = {2},
  isbn      = {0370-2693},
  pages     = {364 -- 370},
  year      = {1988},
  abstract  = {The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured over a large x range (0.01<x<0.7). The spin-dependent structure function g1(x) for the proton has been determined and its integral over x found to be 0.114±0.012±0.026, in disagreement with the Ellis-Jaffe sum rule. Assuming the validity of the Bjorken sum rule, this result implies a significant negative value for the integral of g1 for the neutron. These values for the integrals of g1 lead to the conclusion that the total quark spin constitutes a rather small fraction of the spin of the nucleon.},
  language  = {en}
}
@article{Ziemons1989,
  author    = {Ziemons, Karl},
  title     = {An investigation of the spin structure of the proton in deep inelastic scattering of polarised muons and polarised protons},
  series = {Nuclear Physics B},
  volume    = {328},
  journal   = {Nuclear Physics B},
  number    = {1},
  isbn      = {0550-3213},
  pages     = {1 -- 35},
  year      = {1989},
  abstract  = {The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured in the range 0.01<×<0.7. The spin dependent structure function g1(x) for the proton has been determined and, combining the data with earlier SLAC measurements, its integral over x found to be 0.126±0.010(stat.)±0.015(syst.), in disagreement with the Ellis-Jaffe sum rule. Assuming the validity of the Biorken sum rule, this result implies a significant negative value for the integral of g1 for the neutron. These integrals lead to the conclusion, in the na{\"i}ve quark parton model, that the total quark spin constitutes a rather small fraction of the spin of the nucleon. Results are also presented on the asymmetries in inclusive hadron production which are consistent with the above picture.},
  language  = {en}
}
@article{ZiemonsAchtenAuffrayetal.2004,
  author    = {Ziemons, Karl and Achten, R. and Auffray, E. and M{\"u}ller-Veggian, Mattea},
  title     = {The ClearPET™ neuro scanner: a dedicated LSO/LuYAP phoswich small animal PET scanner},
  series = {2004 IEEE Nuclear Science Symposium conference record : Nuclear Science Symposium, Medical Imaging Conference ; 16 - 22 October 2004, Rome, Italy ; [including the Symposium on Nuclear Power System (SNPS), 14th Room Temperature Semiconductor X- and Gamma-Ray Detectors Workshop and special focus workshops] / NPSS, Nuclear \& Plasma Sciences Society. Guest ed.: J. Anthony Seibert},
  journal   = {2004 IEEE Nuclear Science Symposium conference record : Nuclear Science Symposium, Medical Imaging Conference ; 16 - 22 October 2004, Rome, Italy ; [including the Symposium on Nuclear Power System (SNPS), 14th Room Temperature Semiconductor X- and Gamma-Ray Detectors Workshop and special focus workshops] / NPSS, Nuclear \& Plasma Sciences Society. Guest ed.: J. Anthony Seibert},
  publisher = {IEEE Operations Center},
  address   = {Piscataway, NJ},
  issn      = {1082-3654},
  pages     = {2430 -- 2433},
  year      = {2004},
  language  = {en}
}
@article{ZiemonsAuffrayBarbieretal.2004,
  author    = {Ziemons, Karl and Auffray, E. and Barbier, R. and Brandenburg, G.},
  title     = {The ClearPET TM LSO/LuYAP phoswich scanner: a high performance small animal PET system},
  series = {2003 IEEE Nuclear Science Symposium Conference Record, Vol. 3},
  journal   = {2003 IEEE Nuclear Science Symposium Conference Record, Vol. 3},
  issn      = {1082-3654},
  pages     = {1728 -- 1732},
  year      = {2004},
  abstract  = {A 2nd generation high performance small animal PET scanner, called ClearPET™, has been designed and a first prototype is built by working groups of the Crystal Clear Collaboration (CCC). In order to achieve high sensitivity and maintain good uniform spatial resolution over the field of view in high resolution PET systems, it is necessary to extract the depth of interaction (DOI) information and correct for spatial degradation. The design of the first ClearPET™ Demonstrator based on the use of the multi-anode photomultiplier tube (Hamamatsu R7600-M64) and a LSO/LuYAP phoswich matrix. The two crystal layers of 8*8 crystals (2*2*10 mm3) are stacked on each other and mounted without light guide as one to one on the PMT. A unit of four PMTs arranged in-line represents one of 20 sectors of the ring design. The opening diameter of the crystal ring is 137 mm, the axial detector length is 110 mm. The PMT pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the pulse arrival time. Single gamma interactions are recorded and coincidences are found by software. The gantry allows rotation of the detector modules around the field of view. The measurements have been done using the first LSO/LuYAP detector cassettes.},
  language  = {en}
}
@article{ZiemonsAuffrayBarbieretal.2005,
  author    = {Ziemons, Karl and Auffray, E. and Barbier, R. and Brandenburg, G. and Bruyndonckx, P.},
  title     = {The ClearPET™ project: Development of a 2nd generation high-performance small animal PET scanner},
  series = {Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment},
  volume    = {537},
  journal   = {Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment},
  number    = {1-2},
  issn      = {0168-9002},
  pages     = {307 -- 311},
  year      = {2005},
  abstract  = {Second generation high-performance PET scanners, called ClearPET™1, have been developed by working groups of the Crystal Clear Collaboration (CCC). High sensitivity and high spatial resolution for the ClearPET camera is achieved by using a phoswich arrangement combining two different types of lutetium-based scintillator materials: LSO from CTI and LuYAP:Ce from the CCC (ISTC project). In a first ClearPET prototype, phoswich arrangements of 8×8 crystals of 2×2×10 mm3 are coupled to multi-channel photomultiplier tubes (Hamamatsu R7600). A unit of four PMTs arranged in-line represents one of 20 sectors of the ring design. The opening diameter of the ring is 120 mm, the axial detector length is 110 mm.The PMT pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the exact pulse starting time, which is subsequently used for coincidence detection. The gantry allows rotation of the detector modules around the field of view. Preliminary data shows a correct identification of the crystal layer about (98±1)\%. Typically the energy resolution is (23.3±0.5)\% for the luyap layer and (15.4±0.4)\% for the lso layer. early studies showed the timing resolution of 2 ns FWHM and 4.8 ns FWTM. the intrinsic spatial resolution ranges from 1.37 mm to 1.61 mm full-width of half-maximum (FWHM) with a mean of 1.48 mm FWHM. further improvements in image and energy resolution are expected when the system geometry is fully modeled.},
  language  = {en}
}
@article{ZiemonsBerghoffLanskeetal.1988,
  author    = {Ziemons, Karl and Berghoff, G. and Lanske, D. and Schultze, K.},
  title     = {Strangeness production in deep inelastic muon-nucleon scattering},
  series = {Verhandlungen der Deutschen Physikalischen Gesellschaft},
  volume    = {23},
  journal   = {Verhandlungen der Deutschen Physikalischen Gesellschaft},
  number    = {5},
  isbn      = {0420-0195},
  pages     = {T309 -- T309},
  year      = {1988},
  language  = {en}
}
@article{ZiemonsBruyndonckxPerezetal.2008,
  author    = {Ziemons, Karl and Bruyndonckx, P. and Perez, J. M. and Pietrzyk, U. and Rato, P. and Tavernier, S.},
  title     = {Beyond ClearPET: Next Aims},
  series = {5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro Symposium Proceedings ISBI 2008},
  journal   = {5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro Symposium Proceedings ISBI 2008},
  isbn      = {978-1-4244-2003-2},
  pages     = {1421 -- 1424},
  year      = {2008},
  abstract  = {The CRYSTAL CLEAR collaboration, in short CCC, is a consortium of 12 academic institutions, mainly from Europe, joining efforts in the area of developing instrumentation for nuclear medicine and medical imaging. In the framework of the CCC a high performance small animal PET system, called ClearPET, was developed by using new technologies in electronics and crystals in a phoswich arrangement combining two types of lutetium- based scintillator materials: LSO:Ce and LuYAP:Ce. Our next aim will be the development of hybrid image systems. Hybrid MR-PET imaging has many unique advantages for brain research. This has sparked a new research line within CCC for the development of novel MR-PET compatible technologies. MRI is not as sensitive as PET but PET has poorer spatial resolution than MRI. Two major advantages of PET are sensitivity and its ability to acquire metabolic information. To assess these innovations, the development of a 9.4T hybrid animal MR-PET scanner is proposed based on an existing 9.4T MR scanner that will be adapted to enable simultaneous acquisition of MR and PET data using cutting- edge technology for both MR and PET.},
  language  = {en}
}
@article{ZiemonsHeinrichsStreunetal.2004,
  author    = {Ziemons, Karl and Heinrichs, U. and Streun, M. and Pietrzyk, U.},
  title     = {Validation of GEANT3 simulation studies with a dual-head PMT ClearPET™ prototype},
  series = {2003 IEEE Nuclear Science Symposium Conference Record, Vol. 5},
  journal   = {2003 IEEE Nuclear Science Symposium Conference Record, Vol. 5},
  issn      = {1082-3654},
  pages     = {3053 -- 3056},
  year      = {2004},
  abstract  = {The ClearPET™ project is proposed by working groups of the Crystal Clear Collaboration (CCC) to develop a 2nd generation high performance small animal positron emission tomograph (PET). High sensitivity and high spatial resolution is foreseen for the ClearPET™ camera by using a phoswich arrangement combining mixed lutetium yttrium aluminum perovskite (LuYAP:Ce) and lutetium oxyorthosilicate (LSO) scintillating crystals. Design optimizations for the first photomultiplier tube (PMT) based ClearPET camera are done with a Monte-Carlo simulation package implemented on GEANT3 (CERN, Geneva, Switzerland). A dual-head prototype has been built to test the frontend electronics and was used to validate the implementation of the GEANT3 simulation tool. Multiple simulations were performed following the experimental protocols to measure the intrinsic resolution and the sensitivity profile in axial and radial direction. Including a mean energy resolution of about 27.0\% the simulated intrinsic resolution is about (1.41±0.11)mm compared to the measured of (1.48±0.06)mm. The simulated sensitivity profiles show a mean square deviation of 12.6\% in axial direction and 3.6\% in radial direction. Satisfactorily these results are representative for all designs and confirm the scanner geometry.},
  language  = {en}
}
@article{ZiemonsHerzogBosettietal.1992,
  author    = {Ziemons, Karl and Herzog, H. and Bosetti, P. and Feinendegen, L. E.},
  title     = {Iterative image reconstruction with weighted pixel contribution to projection elements},
  series = {European Journal of Nuclear Medicine},
  volume    = {19},
  journal   = {European Journal of Nuclear Medicine},
  number    = {8},
  isbn      = {1619-7089},
  pages     = {588 -- 588},
  year      = {1992},
  language  = {en}
}
@article{ZiemonsHerzogFeinendegen1990,
  author    = {Ziemons, Karl and Herzog, H. and Feinendegen, L. E.},
  title     = {Iterative image reconstruction with weighted pixel contribution to projection element},
  series = {European Journal of Nuclear Medicine},
  volume    = {16},
  journal   = {European Journal of Nuclear Medicine},
  number    = {7},
  isbn      = {1619-7089},
  pages     = {403 -- 403},
  year      = {1990},
  language  = {en}
}
@article{ZiemonsKleinesErkenetal.1997,
  author    = {Ziemons, Karl and Kleines, H. and Erken, I. and Knoben, J. and Zwoll, K.},
  title     = {IME-DV Projekt: M-FIRBe, Multi-Modality Functional Imaging for Brain Research},
  series = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen},
  journal   = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen},
  editor    = {Lehmann, Thomas},
  publisher = {Verl. der. Augustinus-Buchh.},
  address   = {Aachen},
  isbn      = {3-86073-519-5},
  pages     = {363 -- 366},
  year      = {1997},
  language  = {de}
}
@article{OezsoyluAliaziziWagneretal.2024,
  author    = {{\"O}zsoylu, Dua and Aliazizi, Fereshteh and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Template bacteria-free fabrication of surface imprinted polymer-based biosensor for E. coli detection using photolithographic mimics: Hacking bacterial adhesion},
  series = {Biosensors and Bioelectronics},
  volume    = {261},
  journal   = {Biosensors and Bioelectronics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-4235 (eISSN)},
  doi       = {10.1016/j.bios.2024.116491},
  pages     = {11 Seiten},
  year      = {2024},
  abstract  = {As one class of molecular imprinted polymers (MIPs), surface imprinted polymer (SIP)-based biosensors show great potential in direct whole-bacteria detection. Micro-contact imprinting, that involves stamping the template bacteria immobilized on a substrate into a pre-polymerized polymer matrix, is the most straightforward and prominent method to obtain SIP-based biosensors. However, the major drawbacks of the method arise from the requirement for fresh template bacteria and often non-reproducible bacteria distribution on the stamp substrate. Herein, we developed a positive master stamp containing photolithographic mimics of the template bacteria (E. coli) enabling reproducible fabrication of biomimetic SIP-based biosensors without the need for the "real" bacteria cells. By using atomic force and scanning electron microscopy imaging techniques, respectively, the E. coli-capturing ability of the SIP samples was tested, and compared with non-imprinted polymer (NIP)-based samples and control SIP samples, in which the cavity geometry does not match with E. coli cells. It was revealed that the presence of the biomimetic E. coli imprints with a specifically designed geometry increases the sensor E. coli-capturing ability by an "imprinting factor" of about 3. These findings show the importance of geometry-guided physical recognition in bacterial detection using SIP-based biosensors. In addition, this imprinting strategy was employed to interdigitated electrodes and QCM (quartz crystal microbalance) chips. E. coli detection performance of the sensors was demonstrated with electrochemical impedance spectroscopy (EIS) and QCM measurements with dissipation monitoring technique (QCM-D).},
  language  = {en}
}
@article{OezsoyluKizildagSchoeningetal.2019,
  author    = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Effect of plasma treatment on the sensor properties of a light-addressable potentiometric sensor (LAPS)},
  series = {physica status solidi a : applications and materials sciences},
  volume    = {216},
  journal   = {physica status solidi a : applications and materials sciences},
  number    = {20},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201900259},
  pages     = {8 Seiten},
  year      = {2019},
  abstract  = {A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment.},
  language  = {en}
}
@article{OezsoyluKizildagSchoeningetal.2020,
  author    = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS)},
  series = {Physics in Medicine},
  volume    = {10},
  journal   = {Physics in Medicine},
  number    = {100030},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2352-4510},
  doi       = {10.1016/j.phmed.2020.100030},
  pages     = {8},
  year      = {2020},
  abstract  = {Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images.},
  language  = {en}
}