@article{BirgelLeschingerWegmannetal.2018,
  author    = {Birgel, Stefan and Leschinger, Tim and Wegmann, Kilian and Staat, Manfred},
  title     = {Calculation of muscle forces and joint reaction loads in the shoulder area via an OpenSim based computer model},
  series = {tm - Technisches Messen},
  volume    = {85},
  journal   = {tm - Technisches Messen},
  number    = {5},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2196-7113},
  doi       = {10.1515/teme-2017-0114},
  pages     = {321 -- 330},
  year      = {2018},
  abstract  = {Using the OpenSim software and verified anatomical data, a computer model for the calculation of biomechanical parameters is developed and used to determine the effect of a reattachment of the Supraspinatus muscle with a medial displacement of the muscle attachment point, which may be necessary for a rupture of the supraspinatus tendon. The results include the influence of the operation on basic biomechanical parameters such as the lever arm, as well as the calculated the muscle activations for the supraspinatus and deltoid. In addition, the influence on joint stability is examined by an analysis of the joint reaction force. The study provides a detailed description of the used model, as well as medical findings to a reattachment of the supraspinatus. Mit der Software OpenSim und {\"u}berpr{\"u}ften anatomischen Daten wird ein Computermodell zur Berechnung von biomechanischen Parametern entwickelt und genutzt, um den Effekt einer Refixierung des Supraspinatusmuskels mit einer medialen Verschiebung des Muskelansatzpunktes zu ermitteln, wie sie unter anderem nach einem Riss der Supraspinatussehne notwendig sein kann. Die Ergebnisse umfassen hierbei den Einfluss der Operation auf grundlegende biomechanische Parameter wie den Hebelarm sowie die berechneten Muskelaktivierungen f{\"u}r den Supraspinatus und Deltoideus. Zus{\"a}tzlich wird der Einfluss auf die Gelenkstabilit{\"a}t betrachtet und durch eine Analyse der Gelenkreaktionskraft untersucht. Die Studie bietet eine detaillierte Beschreibung des genutzten Modells, sowie medizinische Erkenntnisse zu einer Refixierung des Supraspinatus.},
  language  = {en}
}
@article{BhattaraiStaat2018,
  author    = {Bhattarai, Aroj and Staat, Manfred},
  title     = {Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions},
  series = {Computational and Mathematical Methods in Medicine},
  volume    = {2018},
  journal   = {Computational and Mathematical Methods in Medicine},
  number    = {Article ID 9518076},
  publisher = {Hindawi},
  address   = {New York, NY},
  issn      = {1748-6718},
  doi       = {10.1155/2018/9518076},
  pages     = {1 -- 16},
  year      = {2018},
  abstract  = {After menopause, decreased levels of estrogen and progesterone remodel the collagen of the soft tissues thereby reducing their stiffness. Stress urinary incontinence is associated with involuntary urine leakage due to pathological movement of the pelvic organs resulting from lax suspension system, fasciae, and ligaments. This study compares the changes in the orientation and position of the female pelvic organs due to weakened fasciae, ligaments, and their combined laxity. A mixture theory weighted by respective volume fraction of elastin-collagen fibre compound (5\%), adipose tissue (85\%), and smooth muscle (5\%) is adopted to characterize the mechanical behaviour of the fascia. The load carrying response (other than the functional response to the pelvic organs) of each fascia component, pelvic organs, muscles, and ligaments are assumed to be isotropic, hyperelastic, and incompressible. Finite element simulations are conducted during Valsalva manoeuvre with weakened tissues modelled by reduced tissue stiffness. A significant dislocation of the urethrovesical junction is observed due to weakness of the fascia (13.89 mm) compared to the ligaments (5.47 mm). The dynamics of the pelvic floor observed in this study during Valsalva manoeuvre is associated with urethral-bladder hypermobility, greater levator plate angulation, and positive Q-tip test which are observed in incontinent females.},
  language  = {en}
}
@article{KohlerKirschnerHermannsStaatetal.2018,
  author    = {Kohler, Annette and Kirschner-Hermanns, Ruth and Staat, Manfred and Brehmer, Bernhard},
  title     = {Pathogenese, funktionelle und anatomische Aspekte der weiblichen Belastungsinkontinenz},
  series = {Aktuelle Urologie},
  volume    = {49},
  journal   = {Aktuelle Urologie},
  number    = {1},
  publisher = {Thieme},
  address   = {Stuttgart},
  issn      = {1438-8820},
  doi       = {10.1055/s-0043-120616},
  pages     = {47 -- 51},
  year      = {2018},
  abstract  = {Der vorliegende Artikel fokussiert sich auf die weibliche Belastungsinkontinenz als Insuffizienz der Speicherfunktion der Blase, auch wenn im klinischen Alltag die Harninkontinenz der Frau h{\"a}ufig verschiedene Ursachen hat und insbesondere eine Belastungsinkontinenz im Alter und bei neurologischer Komorbidit{\"a}t nur selten isoliert vorkommt. Das kleine Becken der Frau ist sowohl als Funktions- als auch als strukturelle Einheit zu betrachten. Dabei unterliegen bei der Frau Blase, Harnr{\"o}hre, Geb{\"a}rmutter und Enddarm sowie die muskul{\"a}ren und ligament{\"o}sen Strukturen des kleinen Beckens durch Fertilit{\"a}tsphase, m{\"o}gliche Schwangerschaften, Geburten und Menopausen-Phase, {\"u}ber das „normale Altern" hinaus, gravierenden Ver{\"a}nderungen. This article focuses on female stress incontinence in the form of pelvic floor dysfunction and urethral sphincter deficiency, although isolated stress incontinence accounts for less than half of all incontinence cases. Especially in women of old age and those with neurological comorbidities, the causes of incontinence are mostly multifactorial. Also it has to be considered that the female bladder, urethra, uterus and rectum as well as the muscular and ligamentous structures of the female pelvis minor are affected by phases of fertility, possible pregnancies, births and menopause in addition to the normal ageing process.},
  language  = {de}
}
@article{HeinkeKnickerAlbracht2018,
  author    = {Heinke, Lars N. and Knicker, Axel J. and Albracht, Kirsten},
  title     = {Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes},
  series = {Isokinetics and Exercise Science},
  volume    = {26},
  journal   = {Isokinetics and Exercise Science},
  number    = {4},
  publisher = {IOS Press},
  address   = {Amsterdam},
  issn      = {1878-5913},
  doi       = {10.3233/IES-184111},
  pages     = {265 -- 274},
  year      = {2018},
  abstract  = {BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results.},
  language  = {en}
}
@article{KotliarLanzl2018,
  author    = {Kotliar, Konstantin and Lanzl, Ines},
  title     = {Vaskul{\"a}re Biomarker der retinalen Gef{\"a}βanalyse},
  series = {Klinische Monatsbl{\"a}tter fur Augenheilkunde},
  volume    = {235},
  journal   = {Klinische Monatsbl{\"a}tter fur Augenheilkunde},
  number    = {12},
  publisher = {Thieme},
  address   = {Stuttgart},
  issn      = {0023-2165},
  doi       = {10.1055/a-0774-7987},
  pages     = {1352 -- 1359},
  year      = {2018},
  abstract  = {Mit modernen nicht invasiven bildgebenden Verfahren lassen sich anhand der Fundusfotografie bzw. der optischen Verfilmung Aspekte der funktionellen und strukturellen retinalen Gef{\"a}ßver{\"a}nderungen objektiv untersuchen. Der Zustand und das Verhalten retinaler Gef{\"a}ße beeinflussen im pr{\"a}-, post- und kapillaren Bereich den Blutfluss und str{\"o}mungsbedingte Stoffwechselverh{\"a}ltnisse passiv und aktiv {\"u}ber den Gef{\"a}ßdurchmesser. Retinale Gef{\"a}ße gleichen von Aufbau und Funktion den zerebralen Gef{\"a}ßen und spiegeln den Zustand der Mikrozirkulation wider. Mithilfe von aus den Gef{\"a}ßweiten berechneten Biomarkern soll eine Aussage {\"u}ber die Prognose von systemischen vaskul{\"a}r bedingten Erkrankungen getroffen werden. Die statische retinale Gef{\"a}ßanalyse befasst sich mit der Untersuchung des Zustandes der pr{\"a}- und postkapillaren Gef{\"a}ßdurchmesser der retinalen Mikrozirkulation anhand einer optischen Fundusaufnahme. Bei der dynamischen retinalen Gef{\"a}ßanalyse wird der L{\"a}ngsschnitt eines retinalen Gef{\"a}ßes nicht invasiv funktionell und strukturell {\"u}ber einen Zeitraum vor, w{\"a}hrend und nach einer spezifischen vaskul{\"a}ren Stimulation untersucht. Die genaue Methodologie der Auswertung und die Bezeichnung der Parameter variieren bei unterschiedlichen Ans{\"a}tzen. Mittels retinaler Gef{\"a}ßanalyse wurden bislang mehrere klinische Querschnitts- und Interventionsstudien in der Augenheilkunde und anderen Fachgebieten, inkl. Kardiologie, Neurologie, Neurochirurgie, Nephrologie, Gyn{\"a}kologie, Sportmedizin, Diabetologie, Hypertensiologie usw. durchgef{\"u}hrt. Mit der statischen retinalen Gef{\"a}ßanalyse steht eine kosteng{\"u}nstige, reproduzierbare, nicht invasive Screeningtechnik zur Verf{\"u}gung, um eine prognostische Aussage {\"u}ber die Gef{\"a}ßgesundheit eines individuellen Patienten zu treffen. Die dynamische retinale Gef{\"a}ßanalyse besitzt ein weiteres diagnostisches Anwendungsspektrum als die statische, da sie das Verhalten retinaler Gef{\"a}ße zeitkontinuierlich untersucht. Die Evaluation vaskul{\"a}rer Erkrankungen sowie zerebro- bzw. kardiovaskul{\"a}rer Morbidit{\"a}t und Mortalit{\"a}t mittels mehrerer methodologischer Modalit{\"a}ten retinaler Gef{\"a}ßanalyse mit ihren jeweiligen quantitativen Biomarkern bietet eine zukunftstr{\"a}chtige diagnostische Perspektive. Die interdisziplin{\"a}re klinische Anwendung dieser vaskul{\"a}ren Biomarker gewinnt zunehmend an Bedeutung, sowohl in der Augenheilkunde als auch in anderen Fachgebieten.},
  language  = {de}
}
@article{LapitanRogatkinPersheyevetal.2018,
  author    = {Lapitan, Denis G. and Rogatkin, Dmitrii A. and Persheyev, Sydulla K. and Kotliar, Konstantin},
  title     = {False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter},
  series = {Biomedizinische Technik},
  volume    = {63},
  journal   = {Biomedizinische Technik},
  number    = {4},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {0013-5585},
  doi       = {10.1515/bmt-2017-0060},
  pages     = {439 -- 444},
  year      = {2018},
  abstract  = {Noise in the differential two-channel scheme of a classic laser Doppler flowmetry (LDF) instrument was studied. Formation of false spectral components in the output signal due to beating of electrical signals in the differential amplifier was found out. The improved block-diagram of the flowmeter was developed allowing to reduce the noise.},
  language  = {en}
}
@article{AlbannaKotliarLuekeetal.2018,
  author    = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander},
  title     = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis},
  series = {Plos one},
  volume    = {13},
  journal   = {Plos one},
  number    = {10},
  publisher = {PLOS},
  address   = {San Francisco},
  doi       = {10.1371/journal.pone.0204689},
  pages     = {e0204689},
  year      = {2018},
  abstract  = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.},
  language  = {en}
}
@article{BalakirskiKotliarPaulyetal.2018,
  author    = {Balakirski, Galina and Kotliar, Konstantin and Pauly, Karolin J. and Krings, Laura K. and R{\"u}bben, Albert and Baron, Jens M. and Schmitt, Laurenz},
  title     = {Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience},
  series = {Dermatologic Surgery},
  journal   = {Dermatologic Surgery},
  number    = {44 (12)},
  publisher = {Wolters Kluwer},
  doi       = {10.1097/DSS.0000000000001615},
  pages     = {1525 -- 1536},
  year      = {2018},
  abstract  = {BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7\% (19/284) of the cases. In 95\% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13\% to 29\% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.},
  language  = {en}
}
@article{RittwegerAlbrachtFluecketal.2018,
  author    = {Rittweger, J{\"o}rn and Albracht, Kirsten and Fl{\"u}ck, Martin and Ruoss, Severin and Brocca, Lorenza and Longa, Emanuela and Moriggi, Manuela and Seynnes, Olivier and Di Giulio, Irene and Tenori, Leonardo and Vignoli, Alessia and Capri, Miriam and Gelfi, Cecilia and Luchinat, Claudio and Franceschi, Claudio and Bottinelli, Roberto and Cerretelli, Paolo and Narici, Marco},
  title     = {Sarcolab pilot study into skeletal muscle's adaptation to longterm spaceflight},
  series = {npj Microgravity},
  volume    = {4},
  journal   = {npj Microgravity},
  number    = {1},
  publisher = {Nature Portfolio},
  issn      = {2373-8065},
  doi       = {10.1038/s41526-018-0052-1},
  pages     = {1 -- 9},
  year      = {2018},
  language  = {en}
}
@article{ErmolaevNivokovMelnikovaetal.2018,
  author    = {Ermolaev, A.P. and Nivokov, I.A. and Melnikova, L.I. and Kotliar, Konstantin},
  title     = {Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой},
  series = {Vestnik oftalmologii},
  volume    = {5},
  journal   = {Vestnik oftalmologii},
  number    = {2},
  publisher = {Media Sfera},
  address   = {Moskau},
  doi       = {10.17116/oftalma2018134051195},
  pages     = {195 -- 201},
  year      = {2018},
  abstract  = {Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP.},
  language  = {ru}
}
@article{CiritsisHorbachStaatetal.2018,
  author    = {Ciritsis, Alexander and Horbach, Andreas and Staat, Manfred and Kuhl, Christiane K. and Kraemer, Nils Andreas},
  title     = {Porosity and tissue integration of elastic mesh implants evaluated in vitro and in vivo},
  series = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials},
  volume    = {106},
  journal   = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials},
  number    = {2},
  publisher = {Wiley},
  address   = {New York, NY},
  issn      = {1552-4981},
  doi       = {10.1002/jbm.b.33877},
  pages     = {827 -- 833},
  year      = {2018},
  abstract  = {Purpose In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model. Material and Methods Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro. A group of three pigs each were treated with magnetic resonance imaging (MRI) visible conventional stiff polyvinylidene fluoride meshes (PVDF) or with soft thermoplastic polyurethane meshes (TPU) (FEG Textiltechnik mbH, Aachen, Germany), respectively. MRI was performed with a pneumoperitoneum at a pressure of 0 and 15 mmHg, which resulted in bulging of the abdomen. The mesh-induced signal voids were semiautomatically segmented and the mesh areas were determined. With the deformations assessed in both mesh types at both pressure conditions, the porosity change of the meshes after 8 weeks of ingrowth was calculated as an indicator of preserved elastic properties. The explanted specimens were examined histologically for the maturity of the scar (collagen I/III ratio). Results In TPU, the in vitro porosity increased constantly, in PVDF, a loss of porosity was observed under mild stresses. In vivo, the mean mesh areas of TPU were 206.8 cm2 (± 5.7 cm2) at 0 mmHg pneumoperitoneum and 274.6 cm2 (± 5.2 cm2) at 15 mmHg; for PVDF the mean areas were 205.5 cm2 (± 8.8 cm2) and 221.5 cm2 (± 11.8 cm2), respectively. The pneumoperitoneum-induced pressure increase resulted in a calculated porosity increase of 8.4\% for TPU and of 1.2\% for PVDF. The mean collagen I/III ratio was 8.7 (± 0.5) for TPU and 4.7 (± 0.7) for PVDF. Conclusion The elastic properties of TPU mesh implants result in improved tissue integration compared to conventional PVDF meshes, and they adapt more efficiently to the abdominal wall. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 827-833, 2018.},
  language  = {en}
}
@article{HorbachStaat2018,
  author    = {Horbach, Andreas and Staat, Manfred},
  title     = {Optical strain measurement for the modeling of surgical meshes and their porosity},
  series = {Current Directions in Biomedical Engineering},
  volume    = {Band 4},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {1},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2364-5504},
  doi       = {10.1515/cdbme-2018-0045},
  pages     = {181 -- 184},
  year      = {2018},
  abstract  = {The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.},
  language  = {en}
}
@article{BhattaraiStaat2018,
  author    = {Bhattarai, Aroj and Staat, Manfred},
  title     = {Computational comparison of different textile implants to correct apical prolapse in females},
  series = {Current Directions in Biomedical Engineering},
  volume    = {4},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {1},
  publisher = {De Gruyter},
  address   = {Berlin},
  doi       = {10.1515/cdbme-2018-0159},
  pages     = {661 -- 664},
  year      = {2018},
  abstract  = {Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient's anatomical defect, intended function after reconstruction and most importantly the surgeon's preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared.},
  language  = {en}
}
@article{KeutmannStaatLaack2018,
  author    = {Keutmann, Sabine and Staat, Manfred and Laack, Walter van},
  title     = {Untersuchung der thermischen Auswirkung von therapeutischem Ultraschall},
  volume    = {7},
  number    = {10},
  publisher = {Deutscher {\"A}rzte-Verl.},
  address   = {K{\"o}ln},
  issn      = {2193-5793},
  pages     = {518 -- 522},
  year      = {2018},
  abstract  = {Zusammenfassung: In der Orthop{\"a}die z{\"a}hlt der therapeutische Ultraschall als Mittel zur Pr{\"a}vention und Therapiebegleitung. Er hat mechanische, thermische und physiko-chemische Auswirkungen auf den menschlichen K{\"o}rper. Um mehr Erkenntnisse {\"u}ber die thermischen Auswirkungen zu erlangen, wurden Versuche an einem Hydrogel-Phantom und an Probanden durchgef{\"u}hrt. Dabei entstand eine signifikante Erw{\"a}rmung des Gewebes, welche beim Probandenversuch an der Oberfl{\"a}che und beim Hydrogelversuch in der Tiefe gemessen wurde. Summary: In orthopaedics, therapeutic ultrasound is a tool of prevention and therapy support. It has mechanical, thermal and physico-chemical effects on the human body. Tests with a hydrogel phantom and with human probands have been performed in order to obtain more knowledge about their thermal effects. Both tests measured temperature increases in cell tissue, on the surface with the human proband test and in depth with the hydrogel phantom test.},
  language  = {de}
}
@article{KetelhutGoellBraunsteinetal.2018,
  author    = {Ketelhut, Maike and G{\"o}ll, Fabian and Braunstein, Bj{\"o}rn and Albracht, Kirsten and Abel, Dirk},
  title     = {Comparison of different training algorithms for the leg extension training with an industrial robot},
  series = {Current Directions in Biomedical Engineering},
  volume    = {4},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {1},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2364-5504},
  doi       = {10.1515/cdbme-2018-0005},
  pages     = {17 -- 20},
  year      = {2018},
  abstract  = {In the past, different training scenarios have been developed and implemented on robotic research platforms, but no systematic analysis and comparison have been done so far. This paper deals with the comparison of an isokinematic (motion with constant velocity) and an isotonic (motion against constant weight) training algorithm. Both algorithms are designed for a robotic research platform consisting of a 3D force plate and a high payload industrial robot, which allows leg extension training with arbitrary six-dimensional motion trajectories. In the isokinematic as well as the isotonic training algorithm, individual paths are defined i n C artesian s pace by sufficient s upport p oses. I n t he i sotonic t raining s cenario, the trajectory is adapted to the measured force as the robot should only move along the trajectory as long as the force applied by the user exceeds a minimum threshold. In the isotonic training scenario however, the robot's acceleration is a function of the force applied by the user. To validate these findings, a simulative experiment with a simple linear trajectory is performed. For this purpose, the same force path is applied in both training scenarios. The results illustrate that the algorithms differ in the force dependent trajectory adaption.},
  language  = {en}
}
@article{WerkhausenAlbrachtCroninetal.2018,
  author    = {Werkhausen, Amelie and Albracht, Kirsten and Cronin, Neil J and Paulsen, G{\o}ran and Bojsen-M{\o}ller, Jens and Seynnes, Olivier R},
  title     = {Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing},
  series = {Frontiers in physiology},
  journal   = {Frontiers in physiology},
  number    = {9},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2018.00794},
  pages     = {11 Seiten},
  year      = {2018},
  abstract  = {During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18\%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8\%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21\%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation.},
  language  = {en}
}
@article{LeschingerBirgelHackletal.2019,
  author    = {Leschinger, Tim and Birgel, Stefan and Hackl, Michael and Staat, Manfred and M{\"u}ller, Lars Peter and Wegmann, Kilian},
  title     = {A musculoskeletal shoulder simulation of moment arms and joint reaction forces after medialization of the supraspinatus footprint in rotator cuff repair},
  series = {Computer Methods in Biomechanics and Biomedical Engineering},
  journal   = {Computer Methods in Biomechanics and Biomedical Engineering},
  number    = {Early view},
  publisher = {Taylor \& Francis},
  address   = {London},
  doi       = {10.1080/10255842.2019.1572749},
  year      = {2019},
  language  = {en}
}
@article{LyonsMikuckiGermanetal.2019,
  author    = {Lyons, W. Berry and Mikucki, Jill A. and German, Laura A. and Welch, Kathleen A. and Welch, Susan A. and Gardener, Christopher B. and Tulaczyk, Slawek M. and Pettit, Erin C. and Kowalski, Julia and Dachwald, Bernd},
  title     = {The Geochemistry of Englacial Brine from Taylor Glacier, Antarctica},
  series = {Journal of Geophysical Research: Biogeosciences},
  journal   = {Journal of Geophysical Research: Biogeosciences},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2169-8961},
  doi       = {10.1029/2018JG004411},
  year      = {2019},
  language  = {en}
}
@article{CampenKowalskiLyonsetal.2019,
  author    = {Campen, R. and Kowalski, Julia and Lyons, W.B. and Tulaczyk, S. and Dachwald, Bernd and Pettit, E. and Welch, K. A. and Mikucki, J.A.},
  title     = {Microbial diversity of an Antarctic subglacial community and high-resolution replicate sampling inform hydrological connectivity in a polar desert},
  series = {Environmental Microbiology},
  journal   = {Environmental Microbiology},
  number    = {accepted article},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1462-2920},
  doi       = {10.1111/1462-2920.14607},
  year      = {2019},
  language  = {en}
}
@article{AlbannaLuekeSchubertetal.2019,
  author    = {Albanna, Walid and L{\"u}ke, Jan Niklas and Schubert, Gerrit Alexander and Dibu{\´e}-Adjei, Maxine and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Steiger, Hans-Jakob and H{\"a}nggi, Daniel and Kamp, Marcel A. and Schneider, Toni and Neumaier, Felix},
  title     = {Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity},
  series = {Molecular and Cellular Neuroscience},
  volume    = {96},
  journal   = {Molecular and Cellular Neuroscience},
  number    = {4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1044-7431},
  doi       = {10.1016/j.mcn.2019.03.003},
  pages     = {35 -- 46},
  year      = {2019},
  language  = {en}
}
@article{MeyerGaalenLeschingeretal.2019,
  author    = {Meyer, Carolin and Gaalen, Kerstin van and Leschinger, Tim and Scheyerer, Max J. and Neiss, Wolfram F. and Staat, Manfred and M{\"u}ller, Lars P. and Wegmann, Kilian},
  title     = {Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement},
  series = {BioMed Research International},
  journal   = {BioMed Research International},
  doi       = {10.1155/2019/9232813},
  pages     = {Article ID 9232813},
  year      = {2019},
  language  = {en}
}
@article{JanThimoBauerBieleetal.2019,
  author    = {Jan Thimo, Grundmann and Bauer, Waldemar and Biele, Jens and Boden, Ralf and Ceriotti, Matteo and Cordero, Federico and Dachwald, Bernd and Dumont, Etienne and Grimm, Christian D. and Hercik, David},
  title     = {Capabilities of Gossamer-1 derived small spacecraft solar sails carrying Mascot-derived nanolanders for in-situ surveying of NEAs},
  series = {Acta Astronautica},
  volume    = {156},
  journal   = {Acta Astronautica},
  number    = {3},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0094-5765},
  doi       = {10.1016/j.actaastro.2018.03.019},
  pages     = {330 -- 362},
  year      = {2019},
  language  = {en}
}
@article{JungMuellerStaat2019,
  author    = {Jung, Alexander and M{\"u}ller, Wolfram and Staat, Manfred},
  title     = {Optimization of the flight technique in ski jumping: the influence of wind},
  number    = {Early view},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.jbiomech.2019.03.023},
  year      = {2019},
  language  = {en}
}
@article{SagymbayGENZhetal.2019,
  author    = {Sagymbay, Altynay and G.E., Nusupbaeva and N.Zh, Tleumbetova and A.S., Mutalieva and Nurpeisova, Ainur and D.B., Jussupova and Digel, Ilya},
  title     = {Molecular genetics features of the epidemic season 2017-2018 on the influenza in Kazakhstan},
  series = {Eurasian Journal of Ecology},
  volume    = {58},
  journal   = {Eurasian Journal of Ecology},
  number    = {1},
  isbn      = {2617-7358},
  pages     = {50 -- 60},
  year      = {2019},
  language  = {ru}
}
@article{JungStaat2019,
  author    = {Jung, Alexander and Staat, Manfred},
  title     = {Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue},
  series = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik},
  volume    = {42},
  journal   = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik},
  number    = {4},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1522-2608},
  doi       = {10.1002/gamm.201900002},
  pages     = {11 Seiten},
  year      = {2019},
  language  = {en}
}
@article{LinderBecklerDoerretal.2019,
  author    = {Linder, Peter and Beckler, Matthias and Doerr, Leo and Stoelzle-Feix, Sonja and Fertig, Niels and Jung, Alexander and Staat, Manfred and Gossmann, Matthias},
  title     = {A new in vitro tool to investigate cardiac contractility under physiological mechanical conditions},
  series = {Journal of Pharmacological and Toxicological Methods},
  volume    = {99},
  journal   = {Journal of Pharmacological and Toxicological Methods},
  number    = {Article number 106595},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1056-8719},
  doi       = {10.1016/j.vascn.2019.05.162},
  year      = {2019},
  language  = {en}
}
@article{SavitskayaKistaubayevaIgnatovaetal.2019,
  author    = {Savitskaya, I.S. and Kistaubayeva, A.S. and Ignatova, L.V. and Digel, Ilya},
  title     = {Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells},
  series = {Heliyon},
  volume    = {5},
  journal   = {Heliyon},
  number    = {10},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2405-8440},
  doi       = {10.1016/j.heliyon.2019.e02592},
  pages     = {Artikelnummer e02592},
  year      = {2019},
  language  = {en}
}
@article{SchaelAtanasyanBerdugoetal.2019,
  author    = {Schael, S. and Atanasyan, A. and Berdugo, J. and Bretz, T. and Czupalla, Markus and Dachwald, Bernd and Doetinchem, P. von and Duranti, M. and Gast, H. and Karpinski, W. and Kirn, T. and L{\"u}belsmeyer, K. and Ma{\~n}a, C. and Marrocchesi, P.S. and Mertsch, P. and Moskalenko, I.V. and Schervan, T. and Schluse, M. and Schr{\"o}der, K.-U. and Schultz von Dratzig, A. and Senatore, C. and Spies, L. and Wakely, S.P. and Wlochal, M. and Uglietti, D. and Zimmermann, J.},
  title     = {AMS-100: The next generation magnetic spectrometer in space - An international science platform for physics and astrophysics at Lagrange point 2},
  series = {Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment},
  volume    = {944},
  journal   = {Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment},
  number    = {162561},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0168-9002},
  doi       = {10.1016/j.nima.2019.162561},
  year      = {2019},
  language  = {en}
}
@article{LeschingerBeschAydinetal.2019,
  author    = {Leschinger, Tim and Besch, Katharina and Aydin, Cansu and Staat, Manfred and Scaal, Martin and M{\"u}ller, Lars Peter and Wegmann, Kilian},
  title     = {Irreparable rotator cuff tears: a biomechanical comparison of superior capsuloligamentous complex reconstruction techniques and an interposition graft technique},
  series = {The Orthopaedic Journal of Sports Medicine},
  volume    = {7},
  journal   = {The Orthopaedic Journal of Sports Medicine},
  number    = {8},
  doi       = {10.1177/2325967119864590},
  pages     = {1 -- 5},
  year      = {2019},
  language  = {en}
}
@article{BhattaraiStaat2019,
  author    = {Bhattarai, Aroj and Staat, Manfred},
  title     = {A computational study of organ relocation after laparoscopic pectopexy to repair posthysterectomy vaginal vault prolapse},
  series = {Computer Methods in Biomechanics and Biomedical Engineering: Imaging \& Visualization},
  journal   = {Computer Methods in Biomechanics and Biomedical Engineering: Imaging \& Visualization},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {2168-1171},
  doi       = {10.1080/21681163.2019.1670095},
  year      = {2019},
  language  = {en}
}
@article{MalikAbdievaUalievaetal.2019,
  author    = {Malik, A. M. and Abdieva, G. Zh. and Ualieva, P. S. and Zhubanova, A. A. and Temiz Artmann, Ayseg{\"u}l},
  title     = {CКPИНИНГ МИКPOOPГAНИЗМOВ-ДECТPУКТOPOВ XЛOРOPГAНИЧECКИX ЗAГPЯЗНИТEЛEЙ},
  series = {Eurasian Journal of Ecology},
  volume    = {61},
  journal   = {Eurasian Journal of Ecology},
  number    = {4},
  issn      = {2617-7358},
  pages     = {61 -- 71},
  year      = {2019},
  language  = {ru}
}
@article{AttarMerkKotliaretal.2019,
  author    = {Attar, Mandana Hossein Zadeh and Merk, Hans F. and Kotliar, Konstantin and Wurpts, Gerda and R{\"o}seler, Stefani and Moll-Slodowy, Silke and Plange, Johann and Baron, Jens Malte and Balakirski, Galina},
  title     = {The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria},
  series = {European Journal of Dermatology},
  volume    = {29},
  journal   = {European Journal of Dermatology},
  number    = {6},
  doi       = {10.1684/ejd.2019.3680},
  pages     = {614 -- 618},
  year      = {2019},
  language  = {en}
}
@article{JayaramanMummidisettyLoeschetal.2019,
  author    = {Jayaraman, Chandrasekaran and Mummidisetty, Chaitanya Krishna and Loesch, Alexandra and Kaur, Sandi and Hoppe-Ludwig, Shenan and Staat, Manfred and Jayaraman, Arun},
  title     = {Postural and metabolic benefits of using a forearm support walker in older adults with impairments},
  series = {Archives of Physical Medicine and Rehabilitation},
  volume    = {Volume 100},
  journal   = {Archives of Physical Medicine and Rehabilitation},
  number    = {Issue 4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0003-9993},
  doi       = {10.1016/j.apmr.2018.10.001},
  pages     = {638 -- 647},
  year      = {2019},
  language  = {en}
}
@article{WerkhausenCroninAlbrachtetal.2019,
  author    = {Werkhausen, Amelie and Cronin, Neil J. and Albracht, Kirsten and Bojsen-M{\o}ller, Jens and Seynnes, Olivier R.},
  title     = {Distinct muscle-tendon interaction during running at different speeds and in different loading conditions},
  series = {Journal of Applied Physiology},
  volume    = {127},
  journal   = {Journal of Applied Physiology},
  number    = {1},
  issn      = {1522-1601},
  doi       = {10.1152/japplphysiol.00710.2018},
  pages     = {246 -- 253},
  year      = {2019},
  language  = {en}
}
@article{TurlybekulyPogrebnjakSukhodubetal.2019,
  author    = {Turlybekuly, Amanzhol and Pogrebnjak, Alexander and Sukhodub, L. F. and Sukhodub, Liudmyla B. and Kistaubayeva, A. S. and Savitskaya, Irina and Shokatayeva, D. H. and Bondar, Oleksandr V. and Shaimardanov, Z. K. and Plotnikov, Sergey V. and Shaimardanova, B. H. and Digel, Ilya},
  title     = {Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix},
  series = {Materials Science and Engineering C},
  volume    = {104},
  journal   = {Materials Science and Engineering C},
  number    = {Article number 109965},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.msec.2019.109965},
  year      = {2019},
  language  = {en}
}
@article{ErmolaevErichevAntonovetal.2019,
  author    = {Ermolaev, AP and Erichev, VP and Antonov, AA and Grigoryan, GL and Kotliar, Konstantin and Levitsky, YV and Hderi, K and Mazurova, YV},
  title     = {Assessing retinal photosensitivity in patients with central vision impairment using a portable perimeter (a preliminary report)},
  series = {Vestnik oftalmologii},
  volume    = {135},
  journal   = {Vestnik oftalmologii},
  number    = {3},
  doi       = {10.17116/oftalma201913503146},
  pages     = {46 -- 54},
  year      = {2019},
  language  = {ru}
}
@article{CapriMorsianiSantoroetal.2019,
  author    = {Capri, Miriam and Morsiani, Cristina and Santoro, Aurelia and Moriggi, Manuela and Conte, Maria and Martucci, Morena and Bellavista, Elena and Fabbri, Cristina and Giampieri, Enrico and Albracht, Kirsten and Fl{\"u}ck, Martin and Ruoss, Severin and Brocca, Lorenza and Canepari, Monica and Longa, Emanuela and Giulio, Irene Di and Bottinelli, Roberto and Cerretelli, Paolo and Salvioli, Stefano and Gelfi, Cecilia and Franceschi, Claudio and Narici, Marco and Rittweger, J{\"o}rn},
  title     = {Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting},
  series = {The FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume    = {33},
  journal   = {The FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  number    = {4},
  doi       = {10.1096/fj.201801625R},
  pages     = {5168 -- 5180},
  year      = {2019},
  language  = {en}
}
@article{QuittmannAbelAlbrachtetal.2019,
  author    = {Quittmann, Oliver J. and Abel, Thomas and Albracht, Kirsten and Str{\"u}der, Heiko K.},
  title     = {Reliability of muscular activation patterns and their alterations during incremental handcycling in able-bodied participants},
  series = {Sports Biomechanics},
  journal   = {Sports Biomechanics},
  number    = {Article in press},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1752-6116},
  doi       = {10.1080/14763141.2019.1593496},
  year      = {2019},
  language  = {en}
}
@article{KoppSchmeetsGosauetal.2019,
  author    = {Kopp, Alexander and Schmeets, Ralf and Gosau, Martin and Friedrich, Reinhard E. and Fuest, Sandra and Behbahani, Mehdi and Barbeck, Mike and Rutkowski, Rico and Burg, Simon and Kluwe, Lan and Henningsen, Anders},
  title     = {Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application},
  series = {In Vivo},
  volume    = {33},
  journal   = {In Vivo},
  number    = {3},
  issn      = {1791-7549},
  doi       = {10.21873/invivo.11536},
  pages     = {757 -- 762},
  year      = {2019},
  language  = {en}
}
@article{KodomskoiKotliarSchroederetal.2019,
  author    = {Kodomskoi, Leonid and Kotliar, Konstantin and Schr{\"o}der, Andreas and Weiss, Michael and Hille, Konrad},
  title     = {Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter},
  series = {Journal of Glaucoma},
  journal   = {Journal of Glaucoma},
  number    = {Epub ahead of print},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  issn      = {1057-0829},
  doi       = {10.1097/IJG.0000000000001321},
  year      = {2019},
  language  = {en}
}
@article{KetelhutKolditzGoelletal.2019,
  author    = {Ketelhut, Maike and Kolditz, Melanie and G{\"o}ll, Fabian and Braunstein, Bjoern and Albracht, Kirsten and Abel, Dirk},
  title     = {Admittance control of an industrial robot during resistance training},
  series = {IFAC-PapersOnLine},
  volume    = {52},
  journal   = {IFAC-PapersOnLine},
  number    = {19},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2405-8963},
  doi       = {10.1016/j.ifacol.2019.12.102},
  pages     = {223 -- 228},
  year      = {2019},
  abstract  = {Neuromuscular strength training of the leg extensor muscles plays an important role in the rehabilitation and prevention of age and wealth related diseases. In this paper, we focus on the design and implementation of a Cartesian admittance control scheme for isotonic training, i.e. leg extension and flexion against a predefined weight. For preliminary testing and validation of the designed algorithm an experimental research and development platform consisting of an industrial robot and a force plate mounted at its end-effector has been used. Linear, diagonal and arbitrary two-dimensional motion trajectories with different weights for the leg extension and flexion part are applied. The proposed algorithm is easily adaptable to trajectories consisting of arbitrary six-dimensional poses and allows the implementation of individualized trajectories.},
  language  = {en}
}
@article{WerkhausenCroninAlbrachtetal.2019,
  author    = {Werkhausen, Amelie and Cronin, Neil J. and Albracht, Kirsten and Paulsen, G{\o}ran and Larsen, Askild V. and Bojsen-M{\o}ller, Jens and Seynnes, Olivier R.},
  title     = {Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running},
  series = {PeerJ},
  journal   = {PeerJ},
  publisher = {Peer},
  address   = {London},
  issn      = {21678359},
  doi       = {10.7717/peerj.6764},
  pages     = {18 Seiten},
  year      = {2019},
  abstract  = {Background During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus. Methods Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics. Results Achilles tendon stiffness increased by 18\% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30\% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training. Discussion These results show that a training-induced increase in Achilles tendon stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running.},
  language  = {en}
}
@article{SchierenKleinschmidtSchmutzetal.2019,
  author    = {Schieren, Mark and Kleinschmidt, Joris and Schmutz, Axel and Loop, Torsten and Gatzweiler, Karl-Heinz and Staat, Manfred and Wappler, Frank and Defosse, Jerome},
  title     = {Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study},
  series = {Anaesthesia},
  volume    = {74},
  journal   = {Anaesthesia},
  number    = {12},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  isbn      = {1365-2044},
  doi       = {10.1111/anae.14815},
  year      = {2019},
  language  = {en}
}
@article{TranStaat2020,
  author    = {Tran, Ngoc Trinh and Staat, Manfred},
  title     = {Direct plastic structural design under lognormally distributed strength by chance constrained programming},
  series = {Optimization and Engineering},
  volume    = {21},
  journal   = {Optimization and Engineering},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1573-2924},
  doi       = {10.1007/s11081-019-09437-2},
  pages     = {131 -- 157},
  year      = {2020},
  abstract  = {We propose the so-called chance constrained programming model of stochastic programming theory to analyze limit and shakedown loads of structures under random strength with a lognormal distribution. A dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) is used with three-node linear triangular elements.},
  language  = {en}
}
@article{AbelKahmannMellonetal.2020,
  author    = {Abel, Alexander and Kahmann, Stephanie Lucina and Mellon, Stephen and Staat, Manfred and Jung, Alexander},
  title     = {An open-source tool for the validation of finite element models using three-dimensional full-field measurements},
  series = {Medical Engineering \& Physics},
  volume    = {77},
  journal   = {Medical Engineering \& Physics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1350-4533},
  doi       = {10.1016/j.medengphy.2019.10.015},
  pages     = {125 -- 129},
  year      = {2020},
  abstract  = {Three-dimensional (3D) full-field measurements provide a comprehensive and accurate validation of finite element (FE) models. For the validation, the result of the model and measurements are compared based on two respective point-sets and this requires the point-sets to be registered in one coordinate system. Point-set registration is a non-convex optimization problem that has widely been solved by the ordinary iterative closest point algorithm. However, this approach necessitates a good initialization without which it easily returns a local optimum, i.e. an erroneous registration. The globally optimal iterative closest point (Go-ICP) algorithm has overcome this drawback and forms the basis for the presented open-source tool that can be used for the validation of FE models using 3D full-field measurements. The capability of the tool is demonstrated using an application example from the field of biomechanics. Methodological problems that arise in real-world data and the respective implemented solution approaches are discussed.},
  language  = {en}
}
@article{QuittmannMeskemperAlbrachtetal.2020,
  author    = {Quittmann, Oliver J. and Meskemper, Joshua and Albracht, Kirsten and Abel, Thomas and Foitschik, Tina and Str{\"u}der, Heiko K.},
  title     = {Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs},
  series = {Journal of Electromyography and Kinesiology},
  volume    = {51},
  journal   = {Journal of Electromyography and Kinesiology},
  number    = {Article 102402},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1050-6411},
  doi       = {10.1016/j.jelekin.2020.102402},
  year      = {2020},
  abstract  = {Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA.},
  language  = {en}
}
@article{KoppSchunckGosauetal.2020,
  author    = {Kopp, Alexander and Schunck, Laura and Gosau, Martin and Smeets, Ralf and Burg, Simon and Fuest, Sandra and Kr{\"o}ger, Nadja and Zinser, Max and Krohn, Sebastian and Behbahani, Mehdi and K{\"o}pf, Marius and Lauts, Lisa and Rutkowski, Rico},
  title     = {Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes},
  series = {International Journal of Molecular Sciences},
  volume    = {21},
  journal   = {International Journal of Molecular Sciences},
  number    = {18 art. no. 6704},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms21186704},
  year      = {2020},
  abstract  = {In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live-dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes.},
  language  = {en}
}
@article{GossmannThomasHorvathetal.2020,
  author    = {Gossmann, Matthias and Thomas, Ulrich and Horv{\´a}th, Andr{\´a}s and Dragicevic, Elena and Stoelzle-Feix, Sonja and Jung, Alexander and Raman, Aravind Hariharan and Staat, Manfred and Linder, Peter},
  title     = {A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions},
  series = {Journal of Pharmacological and Toxicological Methods},
  volume    = {105},
  journal   = {Journal of Pharmacological and Toxicological Methods},
  number    = {Article 106843},
  publisher = {Elsevier},
  address   = {New York, NY},
  doi       = {10.1016/j.vascn.2020.106843},
  year      = {2020},
  language  = {en}
}
@article{QuittmannAbelAlbrachtetal.2020,
  author    = {Quittmann, Oliver J. and Abel, Thomas and Albracht, Kirsten and Meskemper, Joshua and Foitschik, Tina and Str{\"u}der, Heiko K.},
  title     = {Biomechanics of handcycling propulsion in a 30-min continuous load test at lactate threshold: Kinetics, kinematics, and muscular activity in able-bodied participants},
  series = {European Journal of Applied Physiology},
  journal   = {European Journal of Applied Physiology},
  number    = {120},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {1439-6327},
  doi       = {10.1007/s00421-020-04373-x},
  pages     = {1403 -- 1415},
  year      = {2020},
  abstract  = {Purpose This study aims to investigate the biomechanics of handcycling during a continuous load trial (CLT) to assess the mechanisms underlying fatigue in upper body exercise. Methods Twelve able-bodied triathletes performed a 30-min CLT at a power output corresponding to lactate threshold in a racing recumbent handcycle mounted on a stationary ergometer. During the CLT, ratings of perceived exertion (RPE), tangential crank kinetics, 3D joint kinematics, and muscular activity of ten muscles of the upper extremity and trunk were examined using motion capturing and surface electromyography. Results During the CLT, spontaneously chosen cadence and RPE increased, whereas crank torque decreased. Rotational work was higher during the pull phase. Peripheral RPE was higher compared to central RPE. Joint range of motion decreased for elbow-flexion and radial-duction. Integrated EMG (iEMG) increased in the forearm flexors, forearm extensors, and M. deltoideus (Pars spinalis). An earlier onset of activation was found for M. deltoideus (Pars clavicularis), M. pectoralis major, M. rectus abdominis, M. biceps brachii, and the forearm flexors. Conclusion Fatigue-related alterations seem to apply analogously in handcycling and cycling. The most distal muscles are responsible for force transmission on the cranks and might thus suffer most from neuromuscular fatigue. The findings indicate that peripheral fatigue (at similar lactate values) is higher in handcycling compared to leg cycling, at least for inexperienced participants. An increase in cadence might delay peripheral fatigue by a reduced vascular occlusion. We assume that the gap between peripheral and central fatigue can be reduced by sport-specific endurance training.},
  language  = {en}
}
@article{RauschHarbrechtKahmannetal.2020,
  author    = {Rausch, Valentin and Harbrecht, Andreas and Kahmann, Stephanie Lucina and Fenten, Thomas and Jovanovic, Nebojsa and Hackl, Michael and M{\"u}ller, Lars P. and Staat, Manfred and Wegmann, Kilian},
  title     = {Osteosynthesis of Phalangeal Fractures: Biomechanical Comparison of Kirschner Wires, Plates, and Compression Screws},
  series = {The Journal of Hand Surgery},
  volume    = {45},
  journal   = {The Journal of Hand Surgery},
  number    = {10},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0363-5023},
  doi       = {10.1016/j.jhsa.2020.04.010},
  pages     = {987.e1 -- 987.e8},
  year      = {2020},
  abstract  = {Purpose The aim of this study was to compare several osteosynthesis techniques (intramedullary headless compression screws, T-plates, and Kirschner wires) for distal epiphyseal fractures of proximal phalanges in a human cadaveric model. Methods A total of 90 proximal phalanges from 30 specimens (index, ring, and middle fingers) were used for this study. After stripping off all soft tissue, a transverse distal epiphyseal fracture was simulated at the proximal phalanx. The 30 specimens were randomly assigned to 1 fixation technique (30 per technique), either a 3.0-mm intramedullary headless compression screw, locking plate fixation with a 2.0-mm T-plate, or 2 oblique 1.0-mm Kirschner wires. Displacement analysis (bending, distraction, and torsion) was performed using optical tracking of an applied random speckle pattern after osteosynthesis. Biomechanical testing was performed with increasing cyclic loading and with cyclic load to failure using a biaxial torsion-tension testing machine. Results Cannulated intramedullary compression screws showed significantly less displacement at the fracture site in torsional testing. Furthermore, screws were significantly more stable in bending testing. Kirschner wires were significantly less stable than plating or screw fixation in any cyclic load to failure test setup. Conclusions Intramedullary compression screws are a highly stable alternative in the treatment of transverse distal epiphyseal phalangeal fractures. Kirschner wires seem to be inferior regarding displacement properties and primary stability. Clinical relevance Fracture fixation of phalangeal fractures using plate osteosynthesis may have the advantage of a very rigid reduction, but disadvantages such as stiffness owing to the more invasive surgical approach and soft tissue irritation should be taken into account. Headless compression screws represent a minimally invasive choice for fixation with good biomechanical properties.},
  language  = {en}
}