@article{PaczkowskiWeissbeckerSchoeningetal.2011,
  author    = {Paczkowski, Sebastian and Weißbecker, Bernhard and Sch{\"o}ning, Michael Josef and Sch{\"u}tz, Stefan},
  title     = {Biosensors on the Basis of Insect Olfaction},
  series = {Insect biotechnology / Andreas Vilcinskas, ed.},
  journal   = {Insect biotechnology / Andreas Vilcinskas, ed.},
  publisher = {Springer},
  address   = {Dordrecht [u.a.]},
  isbn      = {978-90-481-9640-1},
  pages     = {225 -- 240},
  year      = {2011},
  language  = {en}
}
@article{OliveiraMolinnusBegingetal.2021,
  author    = {Oliveira, Danilo A. and Molinnus, Denise and Beging, Stefan and Siqueira Jr, Jos{\´e} R. and Sch{\"o}ning, Michael Josef},
  title     = {Biosensor Based on Self-Assembled Films of Graphene Oxide and Polyaniline Using a Field-Effect Device Platform},
  series = {physica status solidi (a) applications and materials science},
  volume    = {218},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {13},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202000747},
  pages     = {1 -- 9},
  year      = {2021},
  abstract  = {A new functionalization method to modify capacitive electrolyte-insulator-semiconductor (EIS) structures with nanofilms is presented. Layers of polyallylamine hydrochloride (PAH) and graphene oxide (GO) with the compound polyaniline:poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PANI:PAAMPSA) are deposited onto a p-Si/SiO2 chip using the layer-by-layer technique (LbL). Two different enzymes (urease and penicillinase) are separately immobilized on top of a five-bilayer stack of the PAH:GO/PANI:PAAMPSA-modified EIS chip, forming a biosensor for detection of urea and penicillin, respectively. Electrochemical characterization is performed by constant capacitance (ConCap) measurements, and the film morphology is characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). An increase in the average sensitivity of the modified biosensors (EIS-nanofilm-enzyme) of around 15\% is found in relation to sensors, only carrying the enzyme but without the nanofilm (EIS-enzyme). In this sense, the nanofilm acts as a stable bioreceptor onto the EIS chip improving the output signal in terms of sensitivity and stability.},
  language  = {en}
}
@inproceedings{OberlaenderReisertKirchneretal.2013,
  author    = {Oberl{\"a}nder, Jan and Reisert, Steffen and Kirchner, Patrick and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Kalorimetrische Gassensoren zur H2O2-Detektion in aseptischen Sterilisationsprozessen},
  series = {11. Dresdner Sensor-Symposium : 9.-11.12.2013},
  booktitle = {11. Dresdner Sensor-Symposium : 9.-11.12.2013},
  organization    = {Dresdner Sensor-Symposium <11, 2013>},
  isbn      = {978-3-9813484-5-3},
  pages     = {234 -- 238},
  year      = {2013},
  language  = {de}
}
@article{OberlaenderMayerGreeffetal.2018,
  author    = {Oberl{\"a}nder, Jan and Mayer, Marlena and Greeff, Anton and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Spore-based biosensor to monitor the microbicidal efficacy of gaseous hydrogen peroxide sterilization processes},
  series = {Biosensors and Bioelectronics},
  volume    = {104},
  journal   = {Biosensors and Bioelectronics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0956-5663},
  doi       = {10.1016/j.bios.2017.12.045},
  pages     = {87 -- 94},
  year      = {2018},
  abstract  = {In this work, a spore-based biosensor is evaluated to monitor the microbicidal efficacy of sterilization processes applying gaseous hydrogen peroxide (H2O2). The sensor is based on interdigitated electrode structures (IDEs) that have been fabricated by means of thin-film technologies. Impedimetric measurements are applied to study the effect of sterilization process on spores of Bacillus atrophaeus. This resilient microorganism is commonly used in industry to proof the sterilization efficiency. The sensor measurements are accompanied by conventional microbiological challenge tests, as well as morphological characterizations with scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The sensor measurements are correlated with the microbiological test routines. In both methods, namely the sensor-based and microbiological one, a tailing effect has been observed. The results are evaluated and discussed in a three-dimensional calibration plot demonstrating the sensor's suitability to enable a rapid process decision in terms of a successfully performed sterilization.},
  language  = {en}
}
@article{OberlaenderKirchnerKeusgenetal.2015,
  author    = {Oberl{\"a}nder, Jan and Kirchner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Strategies in developing thin-film sensors for monitoring aseptic food processes : Theoretical considerations and investigations of passivation materials},
  series = {Electrochimica Acta},
  volume    = {183},
  journal   = {Electrochimica Acta},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0013-4686},
  doi       = {10.1016/j.electacta.2015.06.126},
  pages     = {130 -- 136},
  year      = {2015},
  abstract  = {The sterilization of packages in aseptic food processes is highly significant to maintain a consumer-safe product with extended shelf-life. Today, the sterilization of food packages is predominantly accomplished by gaseous hydrogen peroxide (H2O2) in combination with heat. In order to monitor this sterilization process, calorimetric gas sensors as differential set-up of two platinum temperature sensors representing a catalytically active (additionally deposition of MnO2) and a passive segment have been recently developed. The temperature rise of the exothermic decomposition serves as an indicator of the present H2O2 concentration. In the present work, a theoretical approach considering the sensor's thermochemistry and physical transport phenomena was formulated to evaluate the temperature rise based on the energy content of gaseous H2O2. In a further part of this work, three polymers have been analyzed with respect to their application as passivation materials. The examined polymers are photoresist SU-8, perfluoroalkoxy (PFA) and fluorinated ethylene propylene (FEP). Thermal analyses by means of differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) have been conducted to determine the operation limits of the polymers. The overall chemical resistance and stability of the polymers against the harsh environmental conditions during the sterilization process have been examined by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR).},
  language  = {en}
}
@inproceedings{OberlaenderKirchnerKeusgenetal.2014,
  author    = {Oberl{\"a}nder, Jan and Kirchner, Patrick and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Flexible polyimide-based calorimetric gas sensors for monitoring hy-drogen peroxide in sterilisation processes of aseptic filling machines},
  series = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)},
  booktitle = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)},
  publisher = {VDE-Verl.},
  address   = {D{\"u}sseldorf},
  organization    = {VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik},
  isbn      = {978-3-8007-3622-5},
  pages     = {1 -- 4},
  year      = {2014},
  language  = {en}
}
@article{OberlaenderKirchnerBoyenetal.2014,
  author    = {Oberl{\"a}nder, Jan and Kirchner, Patrick and Boyen, Hans-Gerd and Sch{\"o}ning, Michael Josef},
  title     = {Detection of hydrogen peroxide vapor by use of manganese(IV) oxide as catalyst for calorimetric gas sensors},
  series = {Physica status solidi A: Applications and materials science},
  volume    = {211},
  journal   = {Physica status solidi A: Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)},
  doi       = {10.1002/pssa.201330359},
  pages     = {1372 -- 1376},
  year      = {2014},
  abstract  = {In this work, the catalyst manganese(IV) oxide (MnO2), of calorimetric gas sensors (to monitor the sterilization agent vaporized hydrogen peroxide) has been investigated in more detail. Chemical analyses by means of X-ray-induced photoelectron spectroscopy have been performed to unravel the surface chemistry prior and after exposure to hydrogen peroxide vapor at elevated temperature, as applied in the sterilization processes of beverage cartons. The surface characterization reveals a change in oxidation states of the metal oxide catalyst after exposure to hydrogen peroxide. Additionally, a cleaning effect of the catalyst, which itself is attached to the sensor surface by means of a polymer interlayer, could be observed.},
  language  = {en}
}
@article{OberlaenderJildehKirchneretal.2015,
  author    = {Oberl{\"a}nder, Jan and Jildeh, Zaid B. and Kirchner, Patrick and Wendeler, Luisa and Bromm, Alexander and Iken, Heiko and Wagner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Study of Interdigitated Electrode Arrays Using Experiments and Finite Element Models for the Evaluation of Sterilization Processes},
  series = {Sensors},
  volume    = {15},
  journal   = {Sensors},
  number    = {10},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s151026115},
  pages     = {26115 -- 26127},
  year      = {2015},
  abstract  = {In this work, a sensor to evaluate sterilization processes with hydrogen peroxide vapor has been characterized. Experimental, analytical and numerical methods were applied to evaluate and study the sensor behavior. The sensor set-up is based on planar interdigitated electrodes. The interdigitated electrode structure consists of 614 electrode fingers spanning over a total sensing area of 20 mm2. Sensor measurements were conducted with and without microbiological spores as well as after an industrial sterilization protocol. The measurements were verified using an analytical expression based on a first-order elliptical integral. A model based on the finite element method with periodic boundary conditions in two dimensions was developed and utilized to validate the experimental findings.},
  language  = {en}
}
@inproceedings{OberlaenderJildehKirchneretal.2015,
  author    = {Oberl{\"a}nder, Jan and Jildeh, Zaid B. and Kirchner, Patrick and Wendeler, Luisa and Bromm, Alexander and Iken, Heiko and Wagner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Experimental and numerical evaluation of interdigitated electrode array for monitoring gaseous sterilization processes},
  series = {12. Dresdner Sensor-Symposium 2015},
  booktitle = {12. Dresdner Sensor-Symposium 2015},
  doi       = {10.5162/12dss2015/P3.11},
  pages     = {163 -- 168},
  year      = {2015},
  language  = {en}
}
@article{OberlaenderBrommWendeleretal.2015,
  author    = {Oberl{\"a}nder, Jan and Bromm, Alexander and Wendeler, Luisa and Iken, Heiko and Palomar Duran, Marlena and Greeff, Anton and Kirchner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Towards a biosensor to monitor the sterilisation efficiency of aseptic filling machines},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431900},
  pages     = {1299 -- 1305},
  year      = {2015},
  abstract  = {Sterilisation processes are compulsory in medicine, pharmacy, and food industries to prevent infections of consumers and microbiological contaminations of products. Monitoring the sterilisation by conventional microbiological methods is time- and lab-consuming. To overcome this problem, in this work a novel biosensor has been proposed. The sensor enables a fast method to evaluate sterilisation processes. By means of thin-film technology the sensor's transducer structures in form of IDEs (interdigitated electrodes) have been fabricated on a silicon substrate. Physical characterisation of the developed sensor was done by AFM, SEM, and profilometry. Impedance analyses were conducted for the electrical characterisation. As microbiological layer spores of B. atrophaeus have been immobilised on the sensing structure; spores of this type are a well-known sterilisation test organism. Impedance measurements at a fixed frequency over time were performed to monitor the immobilisation process. A sterilisation process according to aseptic filling machines was applied to demonstrate the sensor functionality. After both, immobilisation and sterilisation, a change in impedance could successfully be detected.},
  language  = {en}
}
@inproceedings{OberlaenderArreolaHansenetal.2017,
  author    = {Oberl{\"a}nder, Jan and Arreola, Julio and Hansen, Christina and Greeff, Anton and Mayer, Marlena and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Impedimetric Biosensor to Enable Fast Evaluation of Gaseous Sterilization Processes},
  series = {MDPI Proceedings},
  volume    = {1},
  booktitle = {MDPI Proceedings},
  number    = {4},
  doi       = {10.3390/proceedings1040435},
  pages     = {4 Seiten},
  year      = {2017},
  language  = {en}
}
@article{NaetherRolkaPoghossianetal.2005,
  author    = {N{\"a}ther, Niko and Rolka, David and Poghossian, Arshak and Koudelka-Hep, M. and Sch{\"o}ning, Michael Josef},
  title     = {Two microcell flow-injection analysis (FIA) platforms for capacitive silicon-based field-effect sensors},
  series = {Electrochimica Acta. 51 (2005), H. 5},
  journal   = {Electrochimica Acta. 51 (2005), H. 5},
  isbn      = {0013-4686},
  doi       = {10.1016/j.electacta.2005.04.066},
  pages     = {924 -- 929},
  year      = {2005},
  language  = {en}
}
@inproceedings{NaetherPoghossianPlatenetal.2006,
  author    = {N{\"a}ther, Niko and Poghossian, Arshak and Platen, J. and Yoshinobu, T. and Koudelka-Hep, M. and Sch{\"o}ning, Michael Josef},
  title     = {Multi-parameter sensing of both physical and (bio-)chemical quantities using the same transducer principle},
  series = {Biochemical sensing utilisation of micro- and nanotechnologies : Warsaw, [23rd - 26th] November 2005 / ed. by M. Mascini ...},
  booktitle = {Biochemical sensing utilisation of micro- and nanotechnologies : Warsaw, [23rd - 26th] November 2005 / ed. by M. Mascini ...},
  address   = {Warsaw},
  pages     = {172 -- 181},
  year      = {2006},
  language  = {en}
}
@inproceedings{NaetherJuarezEmmerichetal.2006,
  author    = {N{\"a}ther, Niko and Ju{\´a}rez, Leon M. and Emmerich, R{\"u}diger and Berger, J{\"o}rg and Friedrich, Peter and Sch{\"o}ning, Michael Josef},
  title     = {Detection of hydrogen peroxide (H2O2) at exposed temperatures for industrial processes},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1418},
  year      = {2006},
  abstract  = {An H2O2 sensor for the application in industrial sterilisation processes has been developed. Therefore, automated sterilisation equipment at laboratory scale has been constructed using parts from industrial sterilisation facilities. In addition, a software tool has been developed for the control of the sterilisation equipment at laboratory scale. First measurements with the developed sensor set-up as part of the sterilisation equipment have been performed and the sensor has been physically characterised by optical microscopy and SEM.},
  subject      = {Biosensor},
  language  = {en}
}
@article{NaetherHenkelSchneideretal.2009,
  author    = {N{\"a}ther, Niko and Henkel, Hartmut and Schneider, Andreas and Sch{\"o}ning, Michael Josef},
  title     = {Investigation of different catalytically active and passive materials for realising a hydrogen peroxide gas sensor},
  series = {physica status solidi (a) . 206 (2009), H. 3},
  journal   = {physica status solidi (a) . 206 (2009), H. 3},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1862-6319},
  pages     = {449 -- 454},
  year      = {2009},
  language  = {en}
}
@article{NaetherEmmerichBergeretal.2006,
  author    = {N{\"a}ther, Niko and Emmerich, R{\"u}diger and Berger, J{\"o}rg and Friedrich, Peter and Henkel, Hartmut and Schneider, Andreas and Sch{\"o}ning, Michael Josef},
  title     = {A novel gas-phase hydrogen peroxide sensor basing on a combined physical/chemical transduction mechanism},
  series = {Nanofunctional materials, nanostructures, and novel devices for biological and chemical detection : November 27 - December 1, 2006, Boston, Massachusetts, USA ; [at the 2006 MRS Fall Meeting].},
  journal   = {Nanofunctional materials, nanostructures, and novel devices for biological and chemical detection : November 27 - December 1, 2006, Boston, Massachusetts, USA ; [at the 2006 MRS Fall Meeting].},
  publisher = {Materials Research Soc.},
  address   = {Warrendale, Pa.},
  isbn      = {978-1-60423-407-7},
  pages     = {63 -- 68},
  year      = {2006},
  language  = {en}
}
@article{NaetherBergerEmmerichetal.2007,
  author    = {N{\"a}ther, Niko and Berger, J{\"o}rg and Emmerich, R{\"u}diger and Friedrich, Peter and Henkel, Hartmut and Schneider, Andreas and Sch{\"o}ning, Michael Josef},
  title     = {Entwicklung einer kalorimetrischen H2O2-Gassensoranordnung f{\"u}r die Prozessgaskontrolle},
  series = {8. Dresdner Sensor-Symposium : Sensoren f{\"u}r Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme f{\"u}r die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung f{\"u}r die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)},
  journal   = {8. Dresdner Sensor-Symposium : Sensoren f{\"u}r Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme f{\"u}r die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung f{\"u}r die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)},
  publisher = {TUDpress, Verl. der Wissenschaften},
  address   = {Dresden},
  isbn      = {978-3-940046-45-1},
  pages     = {261 -- 264},
  year      = {2007},
  language  = {de}
}
@article{NaetherBergerEmmerichetal.2008,
  author    = {N{\"a}ther, Niko and Berger, J{\"o}rg and Emmerich, R{\"u}diger and Friedrich, P. and Henkel, H. and Sch{\"o}ning, Michael Josef},
  title     = {H2O2-Konzentrationsbestimmung f{\"u}r die Prozessgasanalytik mittels eines kalorimetrischen Sensoraufbaus},
  series = {Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. M{\"a}rz 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik},
  journal   = {Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. M{\"a}rz 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik},
  publisher = {VDI-Verl.},
  address   = {D{\"u}sseldorf},
  isbn      = {978-3-18-092011-5},
  pages     = {783 -- 792},
  year      = {2008},
  language  = {de}
}
@article{NaetherAugerPoghossianetal.2004,
  author    = {N{\"a}ther, Niko and Auger, V. and Poghossian, Arshak and Koudelka-Hep, M. and Sch{\"o}ning, Michael Josef},
  title     = {A miniaturized flow-through cell in SU-8 technique for EIS sensors},
  series = {Biomedizinische Technik. 49 (2004), H. 2},
  journal   = {Biomedizinische Technik. 49 (2004), H. 2},
  isbn      = {0932-4666},
  pages     = {994 -- 995},
  year      = {2004},
  language  = {en}
}
@article{MuschallikMolinnusJablonskietal.2020,
  author    = {Muschallik, Lukas and Molinnus, Denise and Jablonski, Melanie and Kipp, Carina Ronja and Bongaerts, Johannes and Pohl, Martina and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Selmer, Thorsten and Siegert, Petra},
  title     = {Synthesis of α-hydroxy ketones and vicinal (R, R)-diols by Bacillus clausii DSM 8716ᵀ butanediol dehydrogenase},
  series = {RSC Advances},
  volume    = {10},
  journal   = {RSC Advances},
  publisher = {Royal Society of Chemistry (RSC)},
  address   = {Cambridge},
  issn      = {2046-2069},
  doi       = {10.1039/D0RA02066D},
  pages     = {12206 -- 12216},
  year      = {2020},
  abstract  = {α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716ᵀ (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn²⁺ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated.},
  language  = {en}
}
@article{MuschallikMolinnusBongaertsetal.2017,
  author    = {Muschallik, Lukas and Molinnus, Denise and Bongaerts, Johannes and Pohl, Martina and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Siegert, Petra and Selmer, Thorsten},
  title     = {(R,R)-Butane-2,3-diol Dehydrogenase from Bacillus clausii DSM 8716T: Cloning and Expression of the bdhA-Gene, and Initial Characterization of Enzyme},
  series = {Journal of Biotechnology},
  volume    = {258},
  journal   = {Journal of Biotechnology},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0168-1656},
  doi       = {10.1016/j.jbiotec.2017.07.020},
  pages     = {41 -- 50},
  year      = {2017},
  abstract  = {The gene encoding a putative (R,R)-butane-2,3-diol dehydrogenase (bdhA) from Bacillus clausii DSM 8716T was isolated, sequenced and expressed in Escherichia coli. The amino acid sequence of the encoded protein is only distantly related to previously studied enzymes (identity 33-43\%) and exhibited some uncharted peculiarities. An N-terminally StrepII-tagged enzyme variant was purified and initially characterized. The isolated enzyme catalyzed the (R)-specific oxidation of (R,R)- and meso-butane-2,3-diol to (R)- and (S)-acetoin with specific activities of 12 U/mg and 23 U/mg, respectively. Likewise, racemic acetoin was reduced with a specific activity of up to 115 U/mg yielding a mixture of (R,R)- and meso-butane-2,3-diol, while the enzyme reduced butane-2,3-dione (Vmax 74 U/mg) solely to (R,R)-butane-2,3-diol via (R)-acetoin. For these reactions only activity with the co-substrates NADH/NAD+ was observed. The enzyme accepted a selection of vicinal diketones, α-hydroxy ketones and vicinal diols as alternative substrates. Although the physiological function of the enzyme in B. clausii remains elusive, the data presented herein clearly demonstrates that the encoded enzyme is a genuine (R,R)-butane-2,3-diol dehydrogenase with potential for applications in biocatalysis and sensor development.},
  language  = {en}
}
@article{MuschallikKippReckeretal.2020,
  author    = {Muschallik, Lukas and Kipp, Carina Ronja and Recker, Inga and Bongaerts, Johannes and Pohl, Martina and Gelissen, Melanie and Sch{\"o}ning, Michael Josef and Selmer, Thorsten and Siegert, Petra},
  title     = {Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase},
  series = {Journal of Biotechnology},
  volume    = {202},
  journal   = {Journal of Biotechnology},
  number    = {Vol. 324},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {2590-1559},
  doi       = {10.1016/j.jbiotec.2020.09.016},
  pages     = {61 -- 70},
  year      = {2020},
  abstract  = {The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled.},
  language  = {en}
}
@article{MuribYeapMartensetal.2014,
  author    = {Murib, Mohammed Sharif and Yeap, Weng-Siang and Martens, Daan and Bienstman, Peter and Ceuninck, Ward de and Grinsven, Bart van and Sch{\"o}ning, Michael Josef and Michiels, Luc and Haenen, Ken and Ameloot, Marcel and Serpeng{\"u}zel, Ali and Wagner, Patrick},
  title     = {Photonic detection and characterization of DNA using sapphire microspheres},
  series = {Journal of biomedical optics},
  volume    = {19},
  journal   = {Journal of biomedical optics},
  number    = {9},
  publisher = {SPIE},
  address   = {Bellingham},
  issn      = {1560-2281 (E-Journal); 1083-3668 (Print)},
  doi       = {10.1117/1.JBO.19.9.097006},
  pages     = {097006},
  year      = {2014},
  abstract  = {A microcavity-based deoxyribonucleic acid (DNA) optical biosensor is demonstrated for the first time using synthetic sapphire for the optical cavity. Transmitted and elastic scattering intensity at 1510 nm are analyzed from a sapphire microsphere (radius 500  μm, refractive index 1.77) on an optical fiber half coupler. The 0.43 nm angular mode spacing of the resonances correlates well with the optical size of the sapphire sphere. Probe DNA consisting of a 36-mer fragment was covalently immobilized on a sapphire microsphere and hybridized with a 29-mer target DNA. Whispering gallery modes (WGMs) were monitored before the sapphire was functionalized with DNA and after it was functionalized with single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The shift in WGMs from the surface modification with DNA was measured and correlated well with the estimated thickness of the add-on DNA layer. It is shown that ssDNA is more uniformly oriented on the sapphire surface than dsDNA. In addition, it is shown that functionalization of the sapphire spherical surface with DNA does not affect the quality factor (Q≈104) of the sapphire microspheres. The use of sapphire is especially interesting because this material is chemically resilient, biocompatible, and widely used for medical implants.},
  language  = {en}
}
@article{MuribTranCeunincketal.2012,
  author    = {Murib, Mohammed S. and Tran, Anh Quang and Ceuninck, Ward de and Sch{\"o}ning, Michael Josef and Nesladek, Milos and Serpeng{\"u}zel, Ali and Wagner, Patrick},
  title     = {Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres},
  series = {Physica Status Solidi A},
  volume    = {209},
  journal   = {Physica Status Solidi A},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201100795},
  pages     = {1804 -- 1810},
  year      = {2012},
  abstract  = {Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400 nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 µm radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection.},
  language  = {en}
}
@article{MuribYeapMartensetal.2015,
  author    = {Murib, M. S. and Yeap, W. S. and Martens, D. and Liu, X. and Bienstman, P. and Fahlman, M. and Sch{\"o}ning, Michael Josef and Michiels, L. and Haenen, K. and Serpeng{\"u}zel, A. and Wagner, Patrick},
  title     = {Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands},
  series = {Sensors and actuators A: Physical},
  volume    = {222},
  journal   = {Sensors and actuators A: Physical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-3069 (E-Journal); 0924-4247 (Print)},
  doi       = {10.1016/j.sna.2014.11.024},
  pages     = {212 -- 219},
  year      = {2015},
  abstract  = {In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor.},
  language  = {en}
}
@article{MuribYeapEurlingsetal.2016,
  author    = {Murib, M. S. and Yeap, W. S. and Eurlings, Y. and Grinsven, B. van and Boyen, H.-G. and Conings, B. and Michiels, L. and Ameloot, M. and Carleer, R. and Warmer, J. and Kaul, P. and Haenen, K. and Sch{\"o}ning, Michael Josef and Ceuninck, W. de and Wagner, P.},
  title     = {Heat-transfer based characterization of DNA on synthetic sapphire chips},
  series = {Sensors and Actuators B: Chemical},
  volume    = {230},
  journal   = {Sensors and Actuators B: Chemical},
  number    = {230},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.02.027},
  pages     = {260 -- 271},
  year      = {2016},
  abstract  = {In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material.},
  language  = {en}
}
@article{MuribGrinsvenGrietenetal.2013,
  author    = {Murib, M. S. and Grinsven, B. van and Grieten, L. and Janssens, S. D. and Vermeeren, V. and Eersels, K. and Broeders, J. and Ameloot, M. and Michiels, L. and Ceuninck, W. De and Haenen, K. and Sch{\"o}ning, Michael Josef and Wagner, Patrick},
  title     = {Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates},
  series = {Physica Status Solidi (A). Vol. 210 (2013), iss. 5},
  journal   = {Physica Status Solidi (A). Vol. 210 (2013), iss. 5},
  publisher = {Wiley-VCH},
  address   = {Berlin},
  issn      = {0031-8965},
  pages     = {911 -- 917},
  year      = {2013},
  language  = {en}
}
@article{MuckWangJacobsetal.2004,
  author    = {Muck, A. and Wang, J. and Jacobs, M. and Chen, G. and Chatrathi, M. P. and Jurka, V. and Vyborny, Z. and Spillmann, S. D. and Sridharan, G. and Sch{\"o}ning, Michael Josef},
  title     = {Fabrication of poly(methyl methacrylate) microfluidic chips by atmospheric molding},
  series = {Analytical Chemistry. 76 (2004), H. 8},
  journal   = {Analytical Chemistry. 76 (2004), H. 8},
  isbn      = {0003-2700},
  pages     = {2290 -- 2297},
  year      = {2004},
  language  = {en}
}
@article{MourzinaSchoeningSchubertetal.2000,
  author    = {Mourzina, Yu.G. and Sch{\"o}ning, Michael Josef and Schubert, J. and Zander, W. and Legin, A. and Vlasov, Y. G. and L{\"u}th, H.},
  title     = {Thin film microsensors for fast heavy metal analysis},
  series = {Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]},
  journal   = {Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]},
  publisher = {MIC, Mikroelektronik Centret},
  address   = {Lyngby, Denmark},
  isbn      = {87-89935-50-0},
  pages     = {839 -- 840},
  year      = {2000},
  language  = {en}
}
@article{MourzinaSchubertZanderetal.2001,
  author    = {Mourzina, Yu. G. and Schubert, J and Zander, W. and Legin, A. and Vlasov, Y. G. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef},
  title     = {Development of multisensor systems based on chalcogenide thin film chemical sensors for the simultaneous multicomponent analysis of metal ions in complex solutions},
  series = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz},
  journal   = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz},
  publisher = {Elsevier [u.a.]},
  address   = {Amsterdam [u.a.]},
  isbn      = {0-08-044014-2},
  pages     = {251 -- 263},
  year      = {2001},
  language  = {en}
}
@article{MourzinaSchoeningSchubertetal.2000,
  author    = {Mourzina, Y.G. and Sch{\"o}ning, Michael Josef and Schubert, J. and Zander, W. and Legin, A. V. and Vlasov, Y. G. and Kordos, P. and L{\"u}th, H.},
  title     = {A new thin film Pb microsensor based on chalcogenide glasses},
  series = {Sensors and Actuators B. 71 (2000), H. 1-2},
  journal   = {Sensors and Actuators B. 71 (2000), H. 1-2},
  isbn      = {0925-4005},
  pages     = {13 -- 18},
  year      = {2000},
  language  = {en}
}
@article{MourzinaYoshinobuErmelenkoetal.2002,
  author    = {Mourzina, Y. and Yoshinobu, T. and Ermelenko, Y. and Furuichi, K. and Vlasov, Y. and Sch{\"o}ning, Michael Josef and Iwasaki, H.},
  title     = {Technology of photocurable membranes for ion sensors based on laser scanned semiconductor transducer (LSST)},
  series = {Book of abstracts / ed. by J. Saneistr.},
  journal   = {Book of abstracts / ed. by J. Saneistr.},
  publisher = {Czech Technical University, Faculty of Electrical Engineering, Department of Measurement},
  address   = {Prague},
  isbn      = {80-01-02576-4},
  pages     = {254 -- 257},
  year      = {2002},
  language  = {en}
}
@article{MourzinaMaiPoghossianetal.2003,
  author    = {Mourzina, Y. and Mai, T. and Poghossian, Arshak and Ermolenko, Y. and Yoshinobu, T. and Vlasov, Y. and Iwasaki, H. and Sch{\"o}ning, Michael Josef},
  title     = {K+-selective field-effect sensors as transducers for bioelectronic applications},
  series = {Electrochimica Acta. 48 (2003), H. 20-22},
  journal   = {Electrochimica Acta. 48 (2003), H. 20-22},
  isbn      = {0013-4686},
  pages     = {3333 -- 3339},
  year      = {2003},
  language  = {en}
}
@article{MourzinaYoshinobuSchubertetal.2001,
  author    = {Mourzina, Y. G. and Yoshinobu, T. and Schubert, J. and L{\"u}th, H. and Iwasaki, H. and Sch{\"o}ning, Michael Josef},
  title     = {Ion-selective lightaddressable potentiometric sensor (LAPS) with chalcogenide thin film by pulsed laser deposition},
  series = {Sensors and Actuators B. 80 (2001), H. 2},
  journal   = {Sensors and Actuators B. 80 (2001), H. 2},
  isbn      = {0925-4005},
  pages     = {136 -- 140},
  year      = {2001},
  language  = {en}
}
@article{MourzinaSchoeningSchubertetal.2001,
  author    = {Mourzina, Y. G. and Sch{\"o}ning, Michael Josef and Schubert, J. and Zander, W. and Legin, A. V. and Vlasov, Y. G. and L{\"u}th, H.},
  title     = {Copper, cadmium and thallium thin film sensors based on chalcogenide glasses},
  series = {Analytica Chimica Acta. 433 (2001)},
  journal   = {Analytica Chimica Acta. 433 (2001)},
  isbn      = {0378-4304},
  pages     = {103 -- 110},
  year      = {2001},
  language  = {en}
}
@article{MourzinaLeginVlasovetal.2001,
  author    = {Mourzina, Y. G. and Legin, A. and Vlasov, Y. G. and Sch{\"o}ning, Michael Josef and Schubert, J. and Zander, W. and L{\"u}th, H.},
  title     = {Thin film chemical sensors based on chalcogenide glasses for „electronic tongue" applications},
  series = {Sensor 2001 : 10th international conference, May 8 - 10, 2001, Exhibition Centre Nuremberg, Germany ; proceedings},
  journal   = {Sensor 2001 : 10th international conference, May 8 - 10, 2001, Exhibition Centre Nuremberg, Germany ; proceedings},
  publisher = {AMA Service},
  address   = {Wunstorf},
  pages     = {137 -- 141},
  year      = {2001},
  language  = {en}
}
@article{MourzinaErmelenkoYoshinobuetal.2003,
  author    = {Mourzina, Y. G. and Ermelenko, Y. E. and Yoshinobu, T. and Vlasov, Y. and Iwasaki, H. and Sch{\"o}ning, Michael Josef},
  title     = {Anionselective light-addressable potentiometric sensors (LAPS) for the determination of nitrate and suphate ions},
  series = {Sensors and Actuators B. 91 (2003), H. 1-3},
  journal   = {Sensors and Actuators B. 91 (2003), H. 1-3},
  isbn      = {0925-4005},
  pages     = {32 -- 38},
  year      = {2003},
  language  = {en}
}
@article{MourzinaYoshinobuErmolenkoetal.2004,
  author    = {Mourzina, Ioulia G. and Yoshinobu, Tatsuo and Ermolenko, Yuri E. and Vlasov, Yuri G. and Sch{\"o}ning, Michael Josef and Iwasaki, H.},
  title     = {Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of lightaddressable potentiometric sensors},
  series = {Microchimica Acta. 144 (2004), H. 1-3},
  journal   = {Microchimica Acta. 144 (2004), H. 1-3},
  isbn      = {0026-3672},
  pages     = {41 -- 50},
  year      = {2004},
  language  = {en}
}
@article{MourzinaYoshinobuErmolenkoetal.2004,
  author    = {Mourzina, I.G. and Yoshinobu, T. and Ermolenko, Y.E. and Vlasov, Y. G. and Sch{\"o}ning, Michael Josef and Iwasaki, H.},
  title     = {Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of light-addressable potentiometric sensors},
  series = {Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors},
  journal   = {Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors},
  publisher = {Japan Association of Chemical Sensors},
  address   = {Fukuoka},
  pages     = {788 -- 789},
  year      = {2004},
  language  = {en}
}
@article{MoseleyHalamekKrameretal.2014,
  author    = {Moseley, Fiona and Halamek, Jan and Kramer, Friederike and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny},
  title     = {An enzyme-based reversible CNOT logic gate realized in a flow system},
  series = {Analyst},
  volume    = {139},
  journal   = {Analyst},
  number    = {8},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1364-5528 (E-Journal) ; 0003-2654 (Print)},
  doi       = {10.1039/C4AN00133H},
  pages     = {1839 -- 1842},
  year      = {2014},
  abstract  = {An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.},
  language  = {en}
}
@inproceedings{MoritzYoshinobuFingeretal.2003,
  author    = {Moritz, Werner and Yoshinobu, Tatsuo and Finger, Friedhelm and Krause, Steffi and Sch{\"o}ning, Michael Josef},
  title     = {Amorphous silicon as semiconductor material for high resolution LAPS},
  series = {Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimar{\~a}es, Portugal, September 21 - 24, 2003},
  booktitle = {Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimar{\~a}es, Portugal, September 21 - 24, 2003},
  pages     = {48 -- 49},
  year      = {2003},
  language  = {en}
}
@article{MoritzYoshinobuFingeretal.2004,
  author    = {Moritz, W. and Yoshinobu, T. and Finger, F. and Krause, S. and Xu, M. and Sch{\"o}ning, Michael Josef},
  title     = {Microscopy of impedance and surface ion concentrations},
  series = {Biomedizinische Technik. 49 (2004), H. 2},
  journal   = {Biomedizinische Technik. 49 (2004), H. 2},
  isbn      = {0932-4666},
  pages     = {1000 -- 1001},
  year      = {2004},
  language  = {en}
}
@article{MoritzYoshinobuFingeretal.2004,
  author    = {Moritz, W. and Yoshinobu, T. and Finger, F. and Krause, S. and Martin-Fernandez, M. and Sch{\"o}ning, Michael Josef},
  title     = {High resolution LAPS using amorphous silicon as the semiconductor material},
  series = {Sensors and Actuators B. 103 (2004), H. 1-2},
  journal   = {Sensors and Actuators B. 103 (2004), H. 1-2},
  isbn      = {0925-4005},
  pages     = {436 -- 444},
  year      = {2004},
  language  = {en}
}
@inproceedings{MorenoDosevBratovetal.2006,
  author    = {Moreno, Lia and Dosev, D. and Bratov, A. and Dominguez, C. and Sch{\"o}ning, Michael Josef and Kloock, Joachim P.},
  title     = {Effect of electrical properties of the surrounding medium on the response of an interdigitated electrode array with chalcogenide glass film},
  series = {XX Eurosensors : 20th anniversary ; G{\"o}teborg, Sweden, 17 - 20 September 2006 ; [proceedings]. - Vol. 1},
  booktitle = {XX Eurosensors : 20th anniversary ; G{\"o}teborg, Sweden, 17 - 20 September 2006 ; [proceedings]. - Vol. 1},
  address   = {G{\"o}teborg},
  isbn      = {978-91-631-9280-7},
  pages     = {384 -- 385},
  year      = {2006},
  language  = {en}
}
@article{MorenoiCodinachsKloockSchoeningetal.2008,
  author    = {Moreno i Codinachs, Lia and Kloock, Joachim P. and Sch{\"o}ning, Michael Josef and Baldi, Antoni and Ipatov, Andrey and Bratov, Andrey and Jimenez-Jorquera, Cecilia},
  title     = {Electronic integrated multisensor tongue applied to grape juice and wine analysis},
  series = {Analyst. 133 (2008)},
  journal   = {Analyst. 133 (2008)},
  isbn      = {1364-5528},
  pages     = {1440 -- 1448},
  year      = {2008},
  language  = {en}
}
@article{MorenoiCodinachsBirkenstockGarmaetal.2009,
  author    = {Moreno i Codinachs, L. and Birkenstock, C. and Garma, T. and Zierold, R. and Bachmann, J. and Nielsch, K. and Sch{\"o}ning, Michael Josef and Fontcuberta i Morral, A.},
  title     = {A micron-sized nanoporous multifunction sensing device},
  series = {physica status solidi (a) . 206 (2009), H. 3},
  journal   = {physica status solidi (a) . 206 (2009), H. 3},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1862-6319},
  pages     = {435 -- 441},
  year      = {2009},
  language  = {en}
}
@article{MoraisSumanSchoeningetal.2023,
  author    = {Morais, Paulo V. and Suman, Pedro H. and Sch{\"o}ning, Michael Josef and Siqueira Junior, Jos{\´e} R. and Orlandi, Marcelo O.},
  title     = {Layer-by-layer film based on Sn₃O₄ nanobelts as sensing units to detect heavy metals using a capacitive field-effect sensor platform},
  series = {Chemosensors},
  volume    = {11},
  journal   = {Chemosensors},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9040},
  doi       = {10.3390/chemosensors11080436},
  pages     = {Artikel 436},
  year      = {2023},
  abstract  = {Lead and nickel, as heavy metals, are still used in industrial processes, and are classified as "environmental health hazards" due to their toxicity and polluting potential. The detection of heavy metals can prevent environmental pollution at toxic levels that are critical to human health. In this sense, the electrolyte-insulator-semiconductor (EIS) field-effect sensor is an attractive sensing platform concerning the fabrication of reusable and robust sensors to detect such substances. This study is aimed to fabricate a sensing unit on an EIS device based on Sn₃O₄ nanobelts embedded in a polyelectrolyte matrix of polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) using the layer-by-layer (LbL) technique. The EIS-Sn₃O₄ sensor exhibited enhanced electrochemical performance for detecting Pb²⁺ and Ni²⁺ ions, revealing a higher affinity for Pb²⁺ ions, with sensitivities of ca. 25.8 mV/decade and 2.4 mV/decade, respectively. Such results indicate that Sn₃O₄ nanobelts can contemplate a feasible proof-of-concept capacitive field-effect sensor for heavy metal detection, envisaging other future studies focusing on environmental monitoring.},
  language  = {en}
}
@article{MoraisSilvaDantasetal.2019,
  author    = {Morais, Paulo V. and Silva, Anielle C. A. and Dantas, Noelio O. and Sch{\"o}ning, Michael Josef and Siqueira, Jos{\´e} R., Jr.},
  title     = {Hybrid Layer-by-Layer Film of Polyelectrolytes-Embedded Catalytic CoFe2O4 Nanocrystals as Sensing Units in Capacitive Electrolyte-Insulator-Semiconductor Devices},
  series = {physica status solidi a : applications and materials sciences},
  volume    = {216},
  journal   = {physica status solidi a : applications and materials sciences},
  number    = {1900044},
  publisher = {Wiley},
  address   = {Weinheim},
  doi       = {10.1002/pssa.201900044},
  pages     = {1 -- 9},
  year      = {2019},
  language  = {en}
}
@article{MoraisGomesSilvaetal.2017,
  author    = {Morais, Paulo V. and Gomes, Vanderley F., Jr. and Silva, Anielle C. A. and Dantas, Noelio O. and Sch{\"o}ning, Michael Josef and Siqueira, Jos{\´e} R., Jr.},
  title     = {Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices},
  series = {Journal of Materials Science},
  volume    = {52},
  journal   = {Journal of Materials Science},
  number    = {20},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1573-4803},
  doi       = {10.1007/s10853-017-1369-y},
  pages     = {12314 -- 12325},
  year      = {2017},
  abstract  = {The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance-voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film's surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications.},
  language  = {en}
}
@article{MolinnusSorichBartzetal.2016,
  author    = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate},
  series = {Sensors and Actuators B: Chemical},
  volume    = {237},
  journal   = {Sensors and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.06.064},
  pages     = {190 -- 195},
  year      = {2016},
  abstract  = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.},
  language  = {en}
}