@article{KetelhutKolditzGoelletal.2019,
  author    = {Ketelhut, Maike and Kolditz, Melanie and G{\"o}ll, Fabian and Braunstein, Bjoern and Albracht, Kirsten and Abel, Dirk},
  title     = {Admittance control of an industrial robot during resistance training},
  series = {IFAC-PapersOnLine},
  volume    = {52},
  journal   = {IFAC-PapersOnLine},
  number    = {19},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2405-8963},
  doi       = {10.1016/j.ifacol.2019.12.102},
  pages     = {223 -- 228},
  year      = {2019},
  abstract  = {Neuromuscular strength training of the leg extensor muscles plays an important role in the rehabilitation and prevention of age and wealth related diseases. In this paper, we focus on the design and implementation of a Cartesian admittance control scheme for isotonic training, i.e. leg extension and flexion against a predefined weight. For preliminary testing and validation of the designed algorithm an experimental research and development platform consisting of an industrial robot and a force plate mounted at its end-effector has been used. Linear, diagonal and arbitrary two-dimensional motion trajectories with different weights for the leg extension and flexion part are applied. The proposed algorithm is easily adaptable to trajectories consisting of arbitrary six-dimensional poses and allows the implementation of individualized trajectories.},
  language  = {en}
}
@article{KezerashviliDachwald2021,
  author    = {Kezerashvili, Roman Ya and Dachwald, Bernd},
  title     = {Preface: Solar sailing: Concepts, technology, and missions II},
  series = {Advances in Space Research},
  volume    = {67},
  journal   = {Advances in Space Research},
  number    = {9},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0273-1177},
  doi       = {10.1016/j.asr.2021.01.037},
  pages     = {2559 -- 2560},
  year      = {2021},
  language  = {en}
}
@incollection{KnottSofroniaGerressenetal.2014,
  author    = {Knott, Thomas C. and Sofronia, Raluca E. and Gerressen, Marcus and Law, Yuen and Davidescu, Arjana and Savii, George G. and Gatzweiler, Karl-Heinz and Staat, Manfred and Kuhlen, Torsten W.},
  title     = {Preliminary bone sawing model for a virtual reality-based training simulator of bilateral sagittal split osteotomy},
  series = {Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789)},
  booktitle = {Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789)},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-12057-7 (Online)},
  doi       = {10.1007/978-3-319-12057-7_1},
  pages     = {1 -- 10},
  year      = {2014},
  abstract  = {Successful bone sawing requires a high level of skill and experience, which could be gained by the use of Virtual Reality-based simulators. A key aspect of these medical simulators is realistic force feedback. The aim of this paper is to model the bone sawing process in order to develop a valid training simulator for the bilateral sagittal split osteotomy, the most often applied corrective surgery in case of a malposition of the mandible. Bone samples from a human cadaveric mandible were tested using a designed experimental system. Image processing and statistical analysis were used for the selection of four models for the bone sawing process. The results revealed a polynomial dependency between the material removal rate and the applied force. Differences between the three segments of the osteotomy line and between the cortical and cancellous bone were highlighted.},
  language  = {en}
}
@article{KnoxBruggemannGossmannetal.2020,
  author    = {Knox, Ronald and Bruggemann, Andrea and Gossmann, Matthias and Thomas, Ulrich and Horv{\´a}th, Andr{\´a}s and Dragicevic, Elena and Stoelzle-Feix, Sonja and Fertig, Niels and Jung, Alexander and Raman, Aravind Hariharan and Staat, Manfred and Linder, Peter},
  title     = {Combining physiological relevance and throughput for in vitro cardiac contractility measurement},
  series = {Biophysical Journal},
  volume    = {118},
  journal   = {Biophysical Journal},
  number    = {Issue 3, Supplement 1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0006-3495},
  doi       = {10.1016/j.bpj.2019.11.3104},
  pages     = {570a},
  year      = {2020},
  abstract  = {Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these.},
  language  = {en}
}
@article{KodomskoiKotliarSchroederetal.2019,
  author    = {Kodomskoi, Leonid and Kotliar, Konstantin and Schr{\"o}der, Andreas and Weiss, Michael and Hille, Konrad},
  title     = {Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter},
  series = {Journal of Glaucoma},
  journal   = {Journal of Glaucoma},
  number    = {Epub ahead of print},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  issn      = {1057-0829},
  doi       = {10.1097/IJG.0000000000001321},
  year      = {2019},
  language  = {en}
}
@article{KolditzAlbinAbeletal.2016,
  author    = {Kolditz, Melanie and Albin, Thivaharan and Abel, Dirk and Fasse, Alessandro and Br{\"u}ggemann, Gert-Peter and Albracht, Kirsten},
  title     = {Evaluation of foot position and orientation as manipulated variables to control external knee adduction moments in leg extension training},
  series = {Computer methods and programs in biomedicine},
  volume    = {171},
  journal   = {Computer methods and programs in biomedicine},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0169-2607},
  doi       = {10.1016/j.cmpb.2016.09.005},
  pages     = {81 -- 86},
  year      = {2016},
  abstract  = {Background and Objective Effective leg extension training at a leg press requires high forces, which need to be controlled to avoid training-induced damage. In order to avoid high external knee adduction moments, which are one reason for unphysiological loadings on knee joint structures, both training movements and the whole reaction force vector need to be observed. In this study, the applicability of lateral and medial changes in foot orientation and position as possible manipulated variables to control external knee adduction moments is investigated. As secondary parameters both the medio-lateral position of the center of pressure and the frontal-plane orientation of the reaction force vector are analyzed. Methods Knee adduction moments are estimated using a dynamic model of the musculoskeletal system together with the measured reaction force vector and the motion of the subject by solving the inverse kinematic and dynamic problem. Six different foot conditions with varying positions and orientations of the foot in a static leg press are evaluated and compared to a neutral foot position. Results Both lateral and medial wedges under the foot and medial and lateral shifts of the foot can influence external knee adduction moments in the presented study with six healthy subjects. Different effects are observed with the varying conditions: the pose of the leg is changed and the direction and center of pressure of the reaction force vector is influenced. Each effect results in a different direction or center of pressure of the reaction force vector. Conclusions The results allow the conclusion that foot position and orientation can be used as manipulated variables in a control loop to actively control knee adduction moments in leg extension training.},
  language  = {en}
}
@inproceedings{KolditzAlbinFasseetal.2015,
  author    = {Kolditz, Melanie and Albin, Thivaharan and Fasse, Alessandro and Br{\"u}ggemann, Gert-Peter and Abel, Dirk and Albracht, Kirsten},
  title     = {Simulative Analysis of Joint Loading During Leg Press Exercise for Control Applications},
  series = {IFAC-PapersOnLine},
  volume    = {48},
  booktitle = {IFAC-PapersOnLine},
  number    = {20},
  doi       = {10.1016/j.ifacol.2015.10.179},
  pages     = {435 -- 440},
  year      = {2015},
  language  = {en}
}
@inproceedings{KolditzAlbrachtFasseetal.2015,
  author    = {Kolditz, Melanie and Albracht, Kirsten and Fasse, Alessandro and Albin, Thivaharan and Br{\"u}ggemann, Gert-Peter and Abel, Dirk},
  title     = {Evaluation of an industrial robot as a leg press training device},
  series = {XV International Symposium on Computer Simulation in Biomechanics July 9th - 11th 2015, Edinburgh, UK},
  booktitle = {XV International Symposium on Computer Simulation in Biomechanics July 9th - 11th 2015, Edinburgh, UK},
  pages     = {41 -- 42},
  year      = {2015},
  language  = {en}
}
@inproceedings{KonstantinidisDachwaldOhndorfetal.2013,
  author    = {Konstantinidis, K. and Dachwald, Bernd and Ohndorf, A. and Dykta, P. and Voigt, K. and F{\"o}rstner, R.},
  title     = {Enceladus explorer (ENEX): A lander mission to probe subglacial water pockets on Saturn's moon enceladus for life},
  series = {64th International Astronautical Congress 2013 (IAC 2013) : Beijing, China, 23 - 27 September 2013. (Proceedings of the International Astronautical Congress, IAC ; 2)},
  booktitle = {64th International Astronautical Congress 2013 (IAC 2013) : Beijing, China, 23 - 27 September 2013. (Proceedings of the International Astronautical Congress, IAC ; 2)},
  publisher = {Curran},
  address   = {Red Hook, NY},
  organization    = {International Astronautical Congress <64, 2013, Beijing>},
  isbn      = {978-1-62993-909-4},
  pages     = {1340 -- 1350},
  year      = {2013},
  language  = {en}
}
@inproceedings{KonstantinidisKowalskiMartinezetal.2015,
  author    = {Konstantinidis, K. and Kowalski, Julia and Martinez, C. F. and Dachwald, Bernd and Ewerhart, D. and F{\"o}rstner, R.},
  title     = {Some necessary technologies for in-situ astrobiology on enceladus},
  series = {Proceedings of the International Astronautical Congress},
  booktitle = {Proceedings of the International Astronautical Congress},
  isbn      = {978-151081893-4},
  pages     = {1354 -- 1372},
  year      = {2015},
  language  = {en}
}
@article{KonstantinidisFloresMartinezDachwaldetal.2015,
  author    = {Konstantinidis, Konstantinos and Flores Martinez, Claudio and Dachwald, Bernd and Ohndorf, Andreas and Dykta, Paul and Bowitz, Pascal and Rudolph, Martin and Digel, Ilya and Kowalski, Julia and Voigt, Konstantin and F{\"o}rstner, Roger},
  title     = {A lander mission to probe subglacial water on Saturn's moon enceladus for life},
  series = {Acta astronautica},
  volume    = {Vol. 106},
  journal   = {Acta astronautica},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1879-2030 (E-Journal); 0094-5765 (Print)},
  pages     = {63 -- 89},
  year      = {2015},
  language  = {en}
}
@article{KoppSchmeetsGosauetal.2019,
  author    = {Kopp, Alexander and Schmeets, Ralf and Gosau, Martin and Friedrich, Reinhard E. and Fuest, Sandra and Behbahani, Mehdi and Barbeck, Mike and Rutkowski, Rico and Burg, Simon and Kluwe, Lan and Henningsen, Anders},
  title     = {Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application},
  series = {In Vivo},
  volume    = {33},
  journal   = {In Vivo},
  number    = {3},
  issn      = {1791-7549},
  doi       = {10.21873/invivo.11536},
  pages     = {757 -- 762},
  year      = {2019},
  language  = {en}
}
@article{KoppSchunckGosauetal.2020,
  author    = {Kopp, Alexander and Schunck, Laura and Gosau, Martin and Smeets, Ralf and Burg, Simon and Fuest, Sandra and Kr{\"o}ger, Nadja and Zinser, Max and Krohn, Sebastian and Behbahani, Mehdi and K{\"o}pf, Marius and Lauts, Lisa and Rutkowski, Rico},
  title     = {Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes},
  series = {International Journal of Molecular Sciences},
  volume    = {21},
  journal   = {International Journal of Molecular Sciences},
  number    = {18 art. no. 6704},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms21186704},
  year      = {2020},
  abstract  = {In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live-dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes.},
  language  = {en}
}
@phdthesis{Kotliar2008,
  author    = {Kotliar, Konstantin},
  title     = {Functional in-vivo assessment and biofluidmechanical analysis of age-related and pathological microstructural changes in retinal vessels [Elektronische Ressource]},
  publisher = {-},
  year      = {2008},
  language  = {en}
}
@incollection{Kotliar2021,
  author    = {Kotliar, Konstantin},
  title     = {Ocular rigidity: clinical approach},
  series = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye},
  booktitle = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye},
  editor    = {Pallikaris, I. and Tsilimbaris, M. K. and Dastiridou, A. I.},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-64422-2},
  doi       = {10.1007/978-3-030-64422-2_2},
  pages     = {15 -- 43},
  year      = {2021},
  abstract  = {The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications.},
  language  = {en}
}
@article{KotliarBauerZamuraev2006,
  author    = {Kotliar, Konstantin and Bauer, S. M. and Zamuraev, L. A.},
  title     = {Model of the transversely isotropic spherical layer for estimation of intraocular pressure changes after intravitreal injections / Bauer, S. M. ; Zamuraev, L. A. ; Kotliar, K. E.},
  series = {Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2},
  journal   = {Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2},
  publisher = {-},
  isbn      = {1812-5123},
  pages     = {41 -- 47},
  year      = {2006},
  language  = {en}
}
@article{KotliarBaumannVilseretal.2011,
  author    = {Kotliar, Konstantin and Baumann, Marcus and Vilser, Walthard and Lanzl, Ines M.},
  title     = {Pulse wave velocity in retinal arteries of healthy volunteers},
  series = {British Journal of Ophthalmology (eBJO)},
  volume    = {95},
  journal   = {British Journal of Ophthalmology (eBJO)},
  number    = {11},
  publisher = {BMJ Publ. Group},
  address   = {London},
  isbn      = {1468-2079},
  pages     = {675 -- 679},
  year      = {2011},
  language  = {en}
}
@article{KotliarHanssenEberhardtetal.2013,
  author    = {Kotliar, Konstantin and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Schmaderer, Christoph and Halle, Martin and Heemann, Uwe and Baumann, M.},
  title     = {Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects},
  series = {Microcirculation},
  journal   = {Microcirculation},
  publisher = {Wiley},
  address   = {Malden},
  issn      = {1549-8719},
  year      = {2013},
  language  = {en}
}
@article{KotliarHauserOrtneretal.2017,
  author    = {Kotliar, Konstantin and Hauser, Christine and Ortner, Marion and Muggenthaler, Claudia and Diehl-Schmid, Janine and Angermann, Susanne and Hapfelmeier, Alexander and Schmaderer, Christoph and Grimmer, Timo},
  title     = {Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer's disease},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-017-13349-5},
  pages     = {1 -- 11},
  year      = {2017},
  language  = {en}
}
@article{KotliarKharoubiSchmidtTrucksaessetal.2009,
  author    = {Kotliar, Konstantin and Kharoubi, A. and Schmidt-Trucks{\"a}ß, A. and Halle, M. and Lanzl, I.},
  title     = {Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons?},
  series = {Acta Ophthalmologica},
  volume    = {Vol. 87},
  journal   = {Acta Ophthalmologica},
  number    = {Suppl. S244},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print)},
  pages     = {0},
  year      = {2009},
  language  = {en}
}
@article{KotliarKoshitzSvetlovaetal.2006,
  author    = {Kotliar, Konstantin and Koshitz, I. N. and Svetlova, O. V. and Zaseeva, M. V.},
  title     = {Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part I Initial theoretical presuppositions, hypotheses and facts / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotli},
  series = {Glaukoma (2006)},
  journal   = {Glaukoma (2006)},
  publisher = {-},
  pages     = {35 -- 53},
  year      = {2006},
  language  = {en}
}
@article{KotliarKoshitzSvetlowaetal.2005,
  author    = {Kotliar, Konstantin and Koshitz, I. N. and Svetlowa, O. V. and Makarov, F. N.},
  title     = {Biomechanical analysis of traditional and contemporary conceptions on pathogenesis of the primary open angle glaucoma / Koshitz, I. N. ; Svetlova, O. V. ; Kotliar, K. E. ; Makarov, F. N. ; Smolnikov, B. A.},
  series = {Glaukoma (2005)},
  journal   = {Glaukoma (2005)},
  publisher = {-},
  pages     = {41 -- 63},
  year      = {2005},
  language  = {en}
}
@article{KotliarKoshitzSvetlowaetal.2006,
  author    = {Kotliar, Konstantin and Koshitz, I. N. and Svetlowa, O. V. and Zaseeva, M. V.},
  title     = {Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar},
  series = {Glaukoma (2006)},
  journal   = {Glaukoma (2006)},
  publisher = {-},
  pages     = {51 -- 70},
  year      = {2006},
  language  = {en}
}
@article{KotliarKozlovaLanzl2009,
  author    = {Kotliar, Konstantin and Kozlova, Tatiana V. and Lanzl, Ines M.},
  title     = {Postoperative aqueous outflow in the human eye after glaucoma filtration surgery: biofluidmechanical considerations},
  series = {Biomedizinische Technik = Biomedical Engineering},
  volume    = {54},
  journal   = {Biomedizinische Technik = Biomedical Engineering},
  number    = {1},
  publisher = {-},
  isbn      = {1862-278X},
  pages     = {14 -- 22},
  year      = {2009},
  language  = {en}
}
@article{KotliarLanzl2011,
  author    = {Kotliar, Konstantin and Lanzl, Ines M.},
  title     = {Can vascular function be assessed by the interpretation of retinal vascular diameter changes?},
  series = {Investigative Ophthalmology \& Visual Science, IOVS. 52 (2011), H. 1},
  journal   = {Investigative Ophthalmology \& Visual Science, IOVS. 52 (2011), H. 1},
  publisher = {ARVO},
  address   = {Rockville, Md.},
  isbn      = {0146-0404},
  pages     = {635 -- 636},
  year      = {2011},
  language  = {en}
}
@article{KotliarLanzlHanssenetal.2012,
  author    = {Kotliar, Konstantin and Lanzl, Ines M. and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Halle, Martin and Heemann, Uwe and Schmidt-Trucks{\"a}ss, Arno and Baumann, Marcus},
  title     = {Does increased blood pressure rather than aging influence retinal pulse wave velocity?},
  series = {Investigative Ophthalmology \& Visual Science, IOVS},
  volume    = {53},
  journal   = {Investigative Ophthalmology \& Visual Science, IOVS},
  number    = {4},
  publisher = {ARVO},
  address   = {Rockville, Md.},
  issn      = {0146-0404},
  doi       = {10.1167/iovs.11-8815},
  pages     = {2119 -- 2126},
  year      = {2012},
  abstract  = {Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself. Methods: A total of 12 young 25.5-year-old (24.0-28.8) [median(1st quartile-3rd quartile)] and 12 senior 68.5-year-old (63.8-71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8-65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5-35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated. Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280-500] RU/s) and in validated healthy seniors (400 [320-510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains. Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV.},
  language  = {en}
}
@article{KotliarLanzlMaieretal.2008,
  author    = {Kotliar, Konstantin and Lanzl, Ines M. and Maier, Mathias and Feucht, Nikolaus},
  title     = {Intraocular pressure effects of pegaptanib (macugen) injections in patients with and without glaucoma / Lanzl, Ines M. ; Maier, Mathias ; Feucht, Nikolaus ; Lohmann, Chris P. ; Kotliar, Konstantin E.},
  series = {American Journal of Ophthalmology . 145 (2008), H. 1},
  journal   = {American Journal of Ophthalmology . 145 (2008), H. 1},
  publisher = {-},
  isbn      = {1879-1891},
  pages     = {185 -- 185},
  year      = {2008},
  language  = {en}
}
@article{KotliarLanzlSchmidtTrucksaessetal.2011,
  author    = {Kotliar, Konstantin and Lanzl, Ines M. and Schmidt-Trucks{\"a}ss, A. and Sitnikova, Diana and Ali, Mohammad and Blume, Katharina and Halle, Martin and Hansser, Henner},
  title     = {Dynamic retinal vessel response to flicker in obesity: A methodological approach},
  series = {Microvascular Research},
  volume    = {81},
  journal   = {Microvascular Research},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0026-2862},
  pages     = {123 -- 128},
  year      = {2011},
  language  = {en}
}
@article{KotliarMaierBaueretal.2007,
  author    = {Kotliar, Konstantin and Maier, Mathias and Bauer, Svetlana and Feucht, Nikolaus},
  title     = {Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model / Kotliar, Konstantin ; Maier, Mathias ; Bauer, Svetlana ; Feucht, Nikolaus ; Lohmann, Chris ; Lanzl, Ines},
  series = {Acta Ophthalmologica Scandinavica. 85 (2007), H. 7},
  journal   = {Acta Ophthalmologica Scandinavica. 85 (2007), H. 7},
  publisher = {-},
  isbn      = {1755-3768},
  pages     = {777 -- 781},
  year      = {2007},
  language  = {en}
}
@article{KotliarMaierBaueretal.2008,
  author    = {Kotliar, Konstantin and Maier, Mathias and Bauer, Svetlana and Feucht, Nikolaus and Lohmann, Chris and Lanzl, Ines},
  title     = {Intravitreal injection of triamcinolone acetonide and intraocular pressure: author's reply},
  series = {Acta Ophthalmologica},
  volume    = {86},
  journal   = {Acta Ophthalmologica},
  number    = {6},
  publisher = {-},
  isbn      = {1755-3768},
  pages     = {692 -- 693},
  year      = {2008},
  language  = {en}
}
@article{KotliarMogilevskiĭShiloetal.2008,
  author    = {Kotliar, Konstantin and Mogilevskiĭ, A. Ia. and Shilo, A. V. and Panchekha, A. P.},
  title     = {[Chaotic non-linear dynamics of alpha-band of the EEg and organization of the cortical activity of P300 wave] / Mogilevskiĭ, A. Ia. ; Kotliar, K. E. ; Shilo, A. V. ; Panchekha, A. P.},
  series = {Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova. 58 (2008), H. 5},
  journal   = {Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova. 58 (2008), H. 5},
  publisher = {-},
  isbn      = {0044-4677},
  pages     = {562 -- 575},
  year      = {2008},
  language  = {en}
}
@article{KotliarMueckeVilseretal.2008,
  author    = {Kotliar, Konstantin and M{\"u}cke, Bruno and Vilser, Walthard and Schilling, Rudolf},
  title     = {Effect of aging on retinal artery blood column diameter measured along the vessel axis / Kotliar, Konstantin E. ; M{\"u}cke, Bruno ; Vilser, Walthard ; Schilling, Rudolf ; Lanzl, Ines M.},
  series = {Investigative Ophthalmology \& Visual Science, IOVS. 49 (2008), H. 5},
  journal   = {Investigative Ophthalmology \& Visual Science, IOVS. 49 (2008), H. 5},
  publisher = {-},
  isbn      = {0146-0404},
  pages     = {2094 -- 2102},
  year      = {2008},
  language  = {en}
}
@article{KotliarNagelVilseretal.2008,
  author    = {Kotliar, Konstantin and Nagel, Edgar and Vilser, Walthard and Lanzl, Ines M.},
  title     = {Functional in vivo assessment of retinal artery microirregularities in glaucoma / Kotliar, Konstantin E. ; Nagel, Edgar ; Vilser, Walthard ; Lanzl, Ines M.},
  series = {Acta Ophthalmologica. 86 (2008), H. 4},
  journal   = {Acta Ophthalmologica. 86 (2008), H. 4},
  publisher = {-},
  isbn      = {1755-3768},
  pages     = {424 -- 433},
  year      = {2008},
  language  = {en}
}
@article{KotliarNagelVilseretal.2010,
  author    = {Kotliar, Konstantin and Nagel, Edgar and Vilser, Walthard and Seidova, Seid-Fatima and Lanzl, Ines},
  title     = {Microstructural alterations of retinal arterial blood column along the vessel axis in systemic hypertension},
  series = {Investigative Ophthalmology \& Visual Science, IOVS},
  volume    = {51},
  journal   = {Investigative Ophthalmology \& Visual Science, IOVS},
  number    = {4},
  publisher = {ARVO},
  address   = {Rockville, Md.},
  issn      = {0146-0404},
  doi       = {10.1167/iovs.09-3649},
  pages     = {2165 -- 2172},
  year      = {2010},
  abstract  = {Purpose: Image analysis by the retinal vessel analyzer (RVA) observes retinal vessels in their dynamic state online noninvasively along a chosen vessel segment. It has been found that high-frequency diameter changes in the retinal artery blood column along the vessel increase significantly in anamnestically healthy volunteers with increasing age and in patients with glaucoma during vascular dilation. This study was undertaken to investigate whether longitudinal sections of the retinal artery blood column are altered in systemic hypertension. Methods: Retinal arteries of 15 untreated patients with essential arterial hypertension (age, 50.9 ± 11.9 years) and of 15 age-matched anamnestically healthy volunteers were examined by RVA. After baseline assessment, a monochromatic luminance flicker (530-600 nm; 12.5 Hz; 20 s) was applied to evoke retinal vasodilation. Differences in amplitude and frequency of spatial artery blood column diameter change along segments (longitudinal arterial profiles) of 1 mm in length were measured and analyzed using Fourier transformation. Results: In the control group, average reduced power spectra (ARPS) of longitudinal arterial profiles did not differ when arteries changed from constriction to dilation. In the systemic hypertension group, ARPS during constriction, baseline, and restoration were identical and differed from ARPS during dilation (P < 0.05). Longitudinal arterial profiles in both groups showed significant dissimilitude at baseline and restoration (P < 0.05). Conclusions: The retinal artery blood column demonstrates microstructural alterations in systemic hypertension and is less irregular along the vessel axis during vessel dilation. These microstructural changes may be an indication of alterations in vessel wall rigidity, vascular endothelial function, and smooth muscle cells in this disease, leading to impaired perfusion and regulation.},
  language  = {en}
}
@article{KotliarOrtnerConradietal.2022,
  author    = {Kotliar, Konstantin and Ortner, Marion and Conradi, Anna and Hacker, Patricia and Hauser, Christine and G{\"u}nthner, Roman and Moser, Michaela and Muggenthaler, Claudia and Diehl-Schmid, Janine and Priller, Josef and Schmaderer, Christoph and Grimmer, Timo},
  title     = {Altered retinal cerebral vessel oscillation frequencies in Alzheimer's disease compatible with impaired amyloid clearance},
  series = {Neurobiology of Aging},
  volume    = {120},
  journal   = {Neurobiology of Aging},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0197-4580},
  doi       = {10.1016/j.neurobiolaging.2022.08.012},
  pages     = {117 -- 127},
  year      = {2022},
  abstract  = {Retinal vessels are similar to cerebral vessels in their structure and function. Moderately low oscillation frequencies of around 0.1 Hz have been reported as the driving force for paravascular drainage in gray matter in mice and are known as the frequencies of lymphatic vessels in humans. We aimed to elucidate whether retinal vessel oscillations are altered in Alzheimer's disease (AD) at the stage of dementia or mild cognitive impairment (MCI). Seventeen patients with mild-to-moderate dementia due to AD (ADD); 23 patients with MCI due to AD, and 18 cognitively healthy controls (HC) were examined using Dynamic Retinal Vessel Analyzer. Oscillatory temporal changes of retinal vessel diameters were evaluated using mathematical signal analysis. Especially at moderately low frequencies around 0.1 Hz, arterial oscillations in ADD and MCI significantly prevailed over HC oscillations and correlated with disease severity. The pronounced retinal arterial vasomotion at moderately low frequencies in the ADD and MCI groups would be compatible with the view of a compensatory upregulation of paravascular drainage in AD and strengthen the amyloid clearance hypothesis.},
  language  = {en}
}
@article{KotliarSvetlovaMakarovetal.2003,
  author    = {Kotliar, Konstantin and Svetlova, O. V. and Makarov, F. N. and Zaseeva, M. V.},
  title     = {Morfologicheskie i funktsional'nye osobennosti resnichnogo poiaska khrustalika kak kliuchevogo ispolnitel'nogo zvena v mekhanizme akkommodatsii glaza cheloveka = Morpho-functional characteristics of lens ciliary body as a key mechanism of accommodation in},
  series = {Morfologiia (Saint Petersburg, Russia). 123 (2003), H. 3},
  journal   = {Morfologiia (Saint Petersburg, Russia). 123 (2003), H. 3},
  publisher = {-},
  isbn      = {1026-3543},
  pages     = {7 -- 16},
  year      = {2003},
  language  = {en}
}
@article{KotliarSvetlovaSourjikovetal.2004,
  author    = {Kotliar, Konstantin and Svetlova, O. V. and Sourjikov, A. V. and Zaseeva, M. V.},
  title     = {Biomechanical peculiarities of aqueous humor production system and outflow regulation system / Svetlova, O. V. ; Sourjikov, A. V. ; Kotliar, K. E. ; Zaseeva, M. V. ; Shukhaev, S. V. ; Koshitz, I. N.},
  series = {Glaukoma (2004)},
  journal   = {Glaukoma (2004)},
  publisher = {-},
  pages     = {66 -- 76},
  year      = {2004},
  language  = {en}
}
@article{KotliarSvetlovaStegaevetal.2004,
  author    = {Kotliar, Konstantin and Svetlova, O. V. and Stegaev, V. A. and Parkhomov, S. D.},
  title     = {Biomechanical substantiation of relatively low efficiency of recurrent laser trabeculoplasty / Svetlova, O. V. ; Stagaev, V. A. ; Parkhomov, S. D. ; Kotliar, K. E. ; Makarov, F. N. ; Smolnikov, B. A. ; Koshitz, I. N.},
  series = {Glaukoma (2004)},
  journal   = {Glaukoma (2004)},
  publisher = {-},
  pages     = {29 -- 39},
  year      = {2004},
  language  = {en}
}
@article{KotliarVilserNageletal.2004,
  author    = {Kotliar, Konstantin and Vilser, Walthatd and Nagel, Edgar and Lanzl, Ines M.},
  title     = {Retinal vessel reaction in response to chromatic flickering light / Kotliar, Konstantin E. ; Vilser, Walthard ; Nagel, Edgar ; Lanzl, Ines M.},
  series = {Graefe's Archive for Clinical and Experimental Ophthalmology. 242 (2004), H. 5},
  journal   = {Graefe's Archive for Clinical and Experimental Ophthalmology. 242 (2004), H. 5},
  publisher = {-},
  isbn      = {1435-702X},
  pages     = {377 -- 392},
  year      = {2004},
  language  = {en}
}
@article{KowalskiLinderZierkeetal.2016,
  author    = {Kowalski, Julia and Linder, Peter and Zierke, S. and Wulfen, B. van and Clemens, J. and Konstantinidis, K. and Ameres, G. and Hoffmann, R. and Mikucki, J. and Tulaczyk, S. and Funke, O. and Blandfort, D. and Espe, Clemens and Feldmann, Marco and Francke, Gero and Hiecker, S. and Plescher, Engelbert and Sch{\"o}ngarth, Sarah and Dachwald, Bernd and Digel, Ilya and Artmann, Gerhard and Eliseev, D. and Heinen, D. and Scholz, F. and Wiebusch, C. and Macht, S. and Bestmann, U. and Reineking, T. and Zetzsche, C. and Schill, K. and F{\"o}rstner, R. and Niedermeier, H. and Szumski, A. and Eissfeller, B. and Naumann, U. and Helbing, K.},
  title     = {Navigation technology for exploration of glacier ice with maneuverable melting probes},
  series = {Cold Regions Science and Technology},
  journal   = {Cold Regions Science and Technology},
  number    = {123},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0165-232X},
  doi       = {10.1016/j.coldregions.2015.11.006},
  pages     = {53 -- 70},
  year      = {2016},
  abstract  = {The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.},
  language  = {en}
}
@article{KozhalakovaZhubanovaMansurovetal.2010,
  author    = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell},
  series = {Science of Central Asia (2010)},
  journal   = {Science of Central Asia (2010)},
  pages     = {50 -- 54},
  year      = {2010},
  language  = {en}
}
@article{KraemerDaabMuelleretal.2013,
  author    = {Kr{\"a}mer, Stefan and Daab, Dominique Jonas and M{\"u}ller, Brigitte and Wagner, Tobias and Baader, Fabian and Hessel, Joana and Gdalewitsch, Georg and Plescher, Engelbert and Dachwald, Bernd and Wahle, Michael and Gierse, Andreas and Vetter, Rudolf and Pf{\"u}tzenreuter, Lysan},
  title     = {Development and flight-testing of a system to isolate vibrations for microgravity experiments on sounding rockets},
  series = {21st ESA Symposium on Rocket and Balloon Research},
  journal   = {21st ESA Symposium on Rocket and Balloon Research},
  pages     = {1 -- 8},
  year      = {2013},
  language  = {en}
}
@article{KuchlerGuenthnerRibeiroetal.2023,
  author    = {Kuchler, Timon and G{\"u}nthner, Roman and Ribeiro, Andrea and Hausinger, Renate and Streese, Lukas and W{\"o}hnl, Anna and Kesseler, Veronika and Negele, Johanna and Assali, Tarek and Carbajo-Lozoya, Javier and Lech, Maciej and Adorjan, Kristina and Stubbe, Hans Christian and Hanssen, Henner and Kotliar, Konstantin and Haller, Berhard and Heemann, Uwe and Schmaderer, Christoph},
  title     = {Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation},
  volume    = {26},
  publisher = {Springer Nature},
  address   = {Dordrecht},
  doi       = {10.1007/s10456-023-09885-6},
  pages     = {547 -- 563},
  year      = {2023},
  abstract  = {Background Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians. Methods In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204). Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42\% ± 1.77\% vs. 4.64\% ± 2.59\%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5-190.2] vs. 189.1 [179.4-197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8-0.9] vs. 0.88 [0.8-0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = - 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters. Conclusion Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management.},
  language  = {en}
}
@article{KuertenKotliarFuestetal.2021,
  author    = {Kuerten, David and Kotliar, Konstantin and Fuest, Matthias and Walter, Peter and Hollstein, Muriel and Plange, Niklas},
  title     = {Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study},
  series = {International Ophthalmology},
  volume    = {41},
  journal   = {International Ophthalmology},
  number    = {41},
  editor    = {Neri, Piergiorgio},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {1573-2630},
  doi       = {10.1007/s10792-021-01876-0},
  pages     = {3109 -- 3119},
  year      = {2021},
  abstract  = {Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect.},
  language  = {en}
}
@inproceedings{KuhlenDigel2017,
  author    = {Kuhlen, Max and Digel, Ilya},
  title     = {Fluorescence signatures and detection limits of ubiquitous terrestrial bio-compounds},
  series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West},
  booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West},
  editor    = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-9814801-9-1},
  doi       = {10.17185/duepublico/43984},
  pages     = {102 -- 103},
  year      = {2017},
  language  = {en}
}
@phdthesis{KurulganDemirci2012,
  author    = {Kurulgan Demirci, Eylem},
  title     = {The effect of rhAPC on contractile tension : an in-vitro sepsis model of cardiomyocytes and endothelial cells},
  year      = {2012},
  language  = {en}
}
@article{KurulganDemirciDemirciTrzewiketal.2011,
  author    = {Kurulgan Demirci, Eylem and Demirci, T. and Trzewik, J{\"u}rgen and Linder, Peter and Karakulah, G. and Artmann, Gerhard and Sakizli, M. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation},
  series = {Cellular and molecular bioengineering. 4 (2011), H. 1},
  journal   = {Cellular and molecular bioengineering. 4 (2011), H. 1},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {1865-5025},
  pages     = {46 -- 55},
  year      = {2011},
  language  = {en}
}
@article{KurulganDemirciDemirciLinderetal.2012,
  author    = {Kurulgan Demirci, Eylem and Demirci, Taylan and Linder, Peter and Trzewik, J{\"u}rgen and Gierkowski, Jessica Ricarda and Gossmann, Matthias and Kayser, Peter and Porst, Dariusz and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells},
  series = {Journal of Bioscience and Bioengineering},
  volume    = {113},
  journal   = {Journal of Bioscience and Bioengineering},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1347-4421},
  doi       = {10.1016/j.jbiosc.2012.03.019},
  pages     = {212 -- 219},
  year      = {2012},
  abstract  = {All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.},
  language  = {en}
}
@inproceedings{KurulganDemirciLinderDemircietal.2010,
  author    = {Kurulgan Demirci, Eylem and Linder, Peter and Demirci, Taylan and Gierkowski, Jessica R. and Digel, Ilya and Gossmann, Matthias and Temiz Artmann, Ayseg{\"u}l},
  title     = {rhAPC reduces the endothelial cell permeability via a decrease of cellular mechanical contractile tensions : [abstract]},
  year      = {2010},
  abstract  = {In this study, the CellDrum technology quanitfying cellular mechanical tension on a pico-scale was used to investigate the effect of LPS (lipopolysaccharide) on HAoEC (Human Aortic Endothelial Cell) tension.},
  subject      = {Endothelzelle},
  language  = {en}
}
@article{KurulganDemirciLinderDemircietal.2009,
  author    = {Kurulgan Demirci, Eylem and Linder, Peter and Demirci, Taylan and Trzewik, J{\"u}rgen and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Contractile tension of endothelial cells: An LPS based in-vitro sepsis model},
  series = {IUBMB Life. 61 (2009), H. 3},
  journal   = {IUBMB Life. 61 (2009), H. 3},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1521-6543},
  pages     = {307 -- 308},
  year      = {2009},
  language  = {en}
}