@article{KonstantinidisFloresMartinezDachwaldetal.2015, author = {Konstantinidis, Konstantinos and Flores Martinez, Claudio and Dachwald, Bernd and Ohndorf, Andreas and Dykta, Paul and Bowitz, Pascal and Rudolph, Martin and Digel, Ilya and Kowalski, Julia and Voigt, Konstantin and F{\"o}rstner, Roger}, title = {A lander mission to probe subglacial water on Saturn's moon enceladus for life}, series = {Acta astronautica}, volume = {Vol. 106}, journal = {Acta astronautica}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1879-2030 (E-Journal); 0094-5765 (Print)}, pages = {63 -- 89}, year = {2015}, language = {en} } @article{KoppSchmeetsGosauetal.2019, author = {Kopp, Alexander and Schmeets, Ralf and Gosau, Martin and Friedrich, Reinhard E. and Fuest, Sandra and Behbahani, Mehdi and Barbeck, Mike and Rutkowski, Rico and Burg, Simon and Kluwe, Lan and Henningsen, Anders}, title = {Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application}, series = {In Vivo}, volume = {33}, journal = {In Vivo}, number = {3}, issn = {1791-7549}, doi = {10.21873/invivo.11536}, pages = {757 -- 762}, year = {2019}, language = {en} } @article{KoppSchunckGosauetal.2020, author = {Kopp, Alexander and Schunck, Laura and Gosau, Martin and Smeets, Ralf and Burg, Simon and Fuest, Sandra and Kr{\"o}ger, Nadja and Zinser, Max and Krohn, Sebastian and Behbahani, Mehdi and K{\"o}pf, Marius and Lauts, Lisa and Rutkowski, Rico}, title = {Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes}, series = {International Journal of Molecular Sciences}, volume = {21}, journal = {International Journal of Molecular Sciences}, number = {18 art. no. 6704}, publisher = {MDPI}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms21186704}, year = {2020}, abstract = {In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live-dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes.}, language = {en} } @phdthesis{Kotliar2008, author = {Kotliar, Konstantin}, title = {Functional in-vivo assessment and biofluidmechanical analysis of age-related and pathological microstructural changes in retinal vessels [Elektronische Ressource]}, publisher = {-}, year = {2008}, language = {en} } @incollection{Kotliar2021, author = {Kotliar, Konstantin}, title = {Ocular rigidity: clinical approach}, series = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye}, booktitle = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye}, editor = {Pallikaris, I. and Tsilimbaris, M. K. and Dastiridou, A. I.}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-64422-2}, doi = {10.1007/978-3-030-64422-2_2}, pages = {15 -- 43}, year = {2021}, abstract = {The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications.}, language = {en} } @article{KotliarBauerZamuraev2006, author = {Kotliar, Konstantin and Bauer, S. M. and Zamuraev, L. A.}, title = {Model of the transversely isotropic spherical layer for estimation of intraocular pressure changes after intravitreal injections / Bauer, S. M. ; Zamuraev, L. A. ; Kotliar, K. E.}, series = {Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2}, journal = {Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2}, publisher = {-}, isbn = {1812-5123}, pages = {41 -- 47}, year = {2006}, language = {en} } @article{KotliarBaumannVilseretal.2011, author = {Kotliar, Konstantin and Baumann, Marcus and Vilser, Walthard and Lanzl, Ines M.}, title = {Pulse wave velocity in retinal arteries of healthy volunteers}, series = {British Journal of Ophthalmology (eBJO)}, volume = {95}, journal = {British Journal of Ophthalmology (eBJO)}, number = {11}, publisher = {BMJ Publ. Group}, address = {London}, isbn = {1468-2079}, pages = {675 -- 679}, year = {2011}, language = {en} } @article{KotliarHanssenEberhardtetal.2013, author = {Kotliar, Konstantin and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Schmaderer, Christoph and Halle, Martin and Heemann, Uwe and Baumann, M.}, title = {Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects}, series = {Microcirculation}, journal = {Microcirculation}, publisher = {Wiley}, address = {Malden}, issn = {1549-8719}, year = {2013}, language = {en} } @article{KotliarHauserOrtneretal.2017, author = {Kotliar, Konstantin and Hauser, Christine and Ortner, Marion and Muggenthaler, Claudia and Diehl-Schmid, Janine and Angermann, Susanne and Hapfelmeier, Alexander and Schmaderer, Christoph and Grimmer, Timo}, title = {Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer's disease}, series = {Scientific Reports}, volume = {7}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, address = {Cham}, issn = {2045-2322}, doi = {10.1038/s41598-017-13349-5}, pages = {1 -- 11}, year = {2017}, language = {en} } @article{KotliarKharoubiSchmidtTrucksaessetal.2009, author = {Kotliar, Konstantin and Kharoubi, A. and Schmidt-Trucks{\"a}ß, A. and Halle, M. and Lanzl, I.}, title = {Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons?}, series = {Acta Ophthalmologica}, volume = {Vol. 87}, journal = {Acta Ophthalmologica}, number = {Suppl. S244}, publisher = {Wiley}, address = {Weinheim}, issn = {1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print)}, pages = {0}, year = {2009}, language = {en} } @article{KotliarKoshitzSvetlovaetal.2006, author = {Kotliar, Konstantin and Koshitz, I. N. and Svetlova, O. V. and Zaseeva, M. V.}, title = {Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part I Initial theoretical presuppositions, hypotheses and facts / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotli}, series = {Glaukoma (2006)}, journal = {Glaukoma (2006)}, publisher = {-}, pages = {35 -- 53}, year = {2006}, language = {en} } @article{KotliarKoshitzSvetlowaetal.2005, author = {Kotliar, Konstantin and Koshitz, I. N. and Svetlowa, O. V. and Makarov, F. N.}, title = {Biomechanical analysis of traditional and contemporary conceptions on pathogenesis of the primary open angle glaucoma / Koshitz, I. N. ; Svetlova, O. V. ; Kotliar, K. E. ; Makarov, F. N. ; Smolnikov, B. A.}, series = {Glaukoma (2005)}, journal = {Glaukoma (2005)}, publisher = {-}, pages = {41 -- 63}, year = {2005}, language = {en} } @article{KotliarKoshitzSvetlowaetal.2006, author = {Kotliar, Konstantin and Koshitz, I. N. and Svetlowa, O. V. and Zaseeva, M. V.}, title = {Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar}, series = {Glaukoma (2006)}, journal = {Glaukoma (2006)}, publisher = {-}, pages = {51 -- 70}, year = {2006}, language = {en} } @article{KotliarKozlovaLanzl2009, author = {Kotliar, Konstantin and Kozlova, Tatiana V. and Lanzl, Ines M.}, title = {Postoperative aqueous outflow in the human eye after glaucoma filtration surgery: biofluidmechanical considerations}, series = {Biomedizinische Technik = Biomedical Engineering}, volume = {54}, journal = {Biomedizinische Technik = Biomedical Engineering}, number = {1}, publisher = {-}, isbn = {1862-278X}, pages = {14 -- 22}, year = {2009}, language = {en} } @article{KotliarLanzl2011, author = {Kotliar, Konstantin and Lanzl, Ines M.}, title = {Can vascular function be assessed by the interpretation of retinal vascular diameter changes?}, series = {Investigative Ophthalmology \& Visual Science, IOVS. 52 (2011), H. 1}, journal = {Investigative Ophthalmology \& Visual Science, IOVS. 52 (2011), H. 1}, publisher = {ARVO}, address = {Rockville, Md.}, isbn = {0146-0404}, pages = {635 -- 636}, year = {2011}, language = {en} } @article{KotliarLanzlHanssenetal.2012, author = {Kotliar, Konstantin and Lanzl, Ines M. and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Halle, Martin and Heemann, Uwe and Schmidt-Trucks{\"a}ss, Arno and Baumann, Marcus}, title = {Does increased blood pressure rather than aging influence retinal pulse wave velocity?}, series = {Investigative Ophthalmology \& Visual Science, IOVS}, volume = {53}, journal = {Investigative Ophthalmology \& Visual Science, IOVS}, number = {4}, publisher = {ARVO}, address = {Rockville, Md.}, issn = {0146-0404}, doi = {10.1167/iovs.11-8815}, pages = {2119 -- 2126}, year = {2012}, abstract = {Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself. Methods: A total of 12 young 25.5-year-old (24.0-28.8) [median(1st quartile-3rd quartile)] and 12 senior 68.5-year-old (63.8-71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8-65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5-35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated. Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280-500] RU/s) and in validated healthy seniors (400 [320-510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains. Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV.}, language = {en} } @article{KotliarLanzlMaieretal.2008, author = {Kotliar, Konstantin and Lanzl, Ines M. and Maier, Mathias and Feucht, Nikolaus}, title = {Intraocular pressure effects of pegaptanib (macugen) injections in patients with and without glaucoma / Lanzl, Ines M. ; Maier, Mathias ; Feucht, Nikolaus ; Lohmann, Chris P. ; Kotliar, Konstantin E.}, series = {American Journal of Ophthalmology . 145 (2008), H. 1}, journal = {American Journal of Ophthalmology . 145 (2008), H. 1}, publisher = {-}, isbn = {1879-1891}, pages = {185 -- 185}, year = {2008}, language = {en} } @article{KotliarLanzlSchmidtTrucksaessetal.2011, author = {Kotliar, Konstantin and Lanzl, Ines M. and Schmidt-Trucks{\"a}ss, A. and Sitnikova, Diana and Ali, Mohammad and Blume, Katharina and Halle, Martin and Hansser, Henner}, title = {Dynamic retinal vessel response to flicker in obesity: A methodological approach}, series = {Microvascular Research}, volume = {81}, journal = {Microvascular Research}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0026-2862}, pages = {123 -- 128}, year = {2011}, language = {en} } @article{KotliarMaierBaueretal.2007, author = {Kotliar, Konstantin and Maier, Mathias and Bauer, Svetlana and Feucht, Nikolaus}, title = {Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model / Kotliar, Konstantin ; Maier, Mathias ; Bauer, Svetlana ; Feucht, Nikolaus ; Lohmann, Chris ; Lanzl, Ines}, series = {Acta Ophthalmologica Scandinavica. 85 (2007), H. 7}, journal = {Acta Ophthalmologica Scandinavica. 85 (2007), H. 7}, publisher = {-}, isbn = {1755-3768}, pages = {777 -- 781}, year = {2007}, language = {en} } @article{KotliarMaierBaueretal.2008, author = {Kotliar, Konstantin and Maier, Mathias and Bauer, Svetlana and Feucht, Nikolaus and Lohmann, Chris and Lanzl, Ines}, title = {Intravitreal injection of triamcinolone acetonide and intraocular pressure: author's reply}, series = {Acta Ophthalmologica}, volume = {86}, journal = {Acta Ophthalmologica}, number = {6}, publisher = {-}, isbn = {1755-3768}, pages = {692 -- 693}, year = {2008}, language = {en} }