@article{BronderPoghossianKeusgenetal.2017,
  author    = {Bronder, Thomas and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors},
  series = {tm - Technisches Messen},
  volume    = {84},
  journal   = {tm - Technisches Messen},
  number    = {10},
  publisher = {De Gruyter},
  address   = {Oldenbourg},
  doi       = {10.1515/teme-2017-0015},
  pages     = {628 -- 634},
  year      = {2017},
  abstract  = {In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA.},
  language  = {en}
}
@article{ArreolaOberlaenderMaetzkowetal.2017,
  author    = {Arreola, Julio and Oberl{\"a}nder, Jan and M{\"a}tzkow, M. and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Surface functionalization for spore-based biosensors with organosilanes},
  series = {Electrochimica Acta},
  volume    = {241},
  journal   = {Electrochimica Acta},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0013-4686},
  doi       = {10.1016/j.electacta.2017.04.157},
  pages     = {237 -- 243},
  year      = {2017},
  abstract  = {In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated.},
  language  = {en}
}
@article{CiritsisHorbachStaatetal.2018,
  author    = {Ciritsis, Alexander and Horbach, Andreas and Staat, Manfred and Kuhl, Christiane K. and Kraemer, Nils Andreas},
  title     = {Porosity and tissue integration of elastic mesh implants evaluated in vitro and in vivo},
  series = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials},
  volume    = {106},
  journal   = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials},
  number    = {2},
  publisher = {Wiley},
  address   = {New York, NY},
  issn      = {1552-4981},
  doi       = {10.1002/jbm.b.33877},
  pages     = {827 -- 833},
  year      = {2018},
  abstract  = {Purpose In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model. Material and Methods Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro. A group of three pigs each were treated with magnetic resonance imaging (MRI) visible conventional stiff polyvinylidene fluoride meshes (PVDF) or with soft thermoplastic polyurethane meshes (TPU) (FEG Textiltechnik mbH, Aachen, Germany), respectively. MRI was performed with a pneumoperitoneum at a pressure of 0 and 15 mmHg, which resulted in bulging of the abdomen. The mesh-induced signal voids were semiautomatically segmented and the mesh areas were determined. With the deformations assessed in both mesh types at both pressure conditions, the porosity change of the meshes after 8 weeks of ingrowth was calculated as an indicator of preserved elastic properties. The explanted specimens were examined histologically for the maturity of the scar (collagen I/III ratio). Results In TPU, the in vitro porosity increased constantly, in PVDF, a loss of porosity was observed under mild stresses. In vivo, the mean mesh areas of TPU were 206.8 cm2 (± 5.7 cm2) at 0 mmHg pneumoperitoneum and 274.6 cm2 (± 5.2 cm2) at 15 mmHg; for PVDF the mean areas were 205.5 cm2 (± 8.8 cm2) and 221.5 cm2 (± 11.8 cm2), respectively. The pneumoperitoneum-induced pressure increase resulted in a calculated porosity increase of 8.4\% for TPU and of 1.2\% for PVDF. The mean collagen I/III ratio was 8.7 (± 0.5) for TPU and 4.7 (± 0.7) for PVDF. Conclusion The elastic properties of TPU mesh implants result in improved tissue integration compared to conventional PVDF meshes, and they adapt more efficiently to the abdominal wall. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 827-833, 2018.},
  language  = {en}
}
@article{HonarvarfardGamellaChannaveerappaetal.2017,
  author    = {Honarvarfard, Elham and Gamella, Maria and Channaveerappa, Devika and Darie, Costel C. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny},
  title     = {Electrochemically Stimulated Insulin Release from a Modified Graphene-functionalized Carbon Fiber Electrode},
  series = {Electroanalysis},
  volume    = {29},
  journal   = {Electroanalysis},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-4109},
  doi       = {10.1002/elan.201700095},
  pages     = {1543 -- 1553},
  year      = {2017},
  abstract  = {A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9-10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of -1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species.},
  language  = {en}
}
@inproceedings{AbelBoninAlbrachtetal.2010,
  author    = {Abel, Thomas and Bonin, Dominik and Albracht, Kirsten and Zeller, Sebastian and Br{\"u}ggemann, Gert-Peter and Burkett, Brendan and Str{\"u}der, Heiko K.},
  title     = {Kinematic profile of the elite handcyclist},
  series = {28th International Conference on Biomechanics in Sports, Marquette, Michigan, USA, July 19 - 23, 2010},
  booktitle = {28th International Conference on Biomechanics in Sports, Marquette, Michigan, USA, July 19 - 23, 2010},
  issn      = {1999-4168},
  pages     = {140 -- 141},
  year      = {2010},
  language  = {en}
}
@inproceedings{BraunsteinGoldmannAlbrachtetal.2013,
  author    = {Braunstein, Bjoern and Goldmann, Jan-Peter and Albracht, Kirsten and Sanno, Maximilian and Willwacher, Steffen and Heinrich, Kai and Herrmann, Volker and Br{\"u}ggemann, Gert-Peter},
  title     = {Joint specific contribution of mechanical power and work during acceleration and top speed in elite sprinters},
  series = {31 International Conference on Biomechanics in Sports, Taipei, Taiwan, July 07 - July 22, 2013},
  booktitle = {31 International Conference on Biomechanics in Sports, Taipei, Taiwan, July 07 - July 22, 2013},
  issn      = {1999-4168},
  year      = {2013},
  language  = {en}
}
@inproceedings{DroszezSannoGoldmannetal.2016,
  author    = {Droszez, Anna and Sanno, Maximilian and Goldmann, Jan-Peter and Albracht, Kirsten and Br{\"u}ggemann, Gerd-Peter and Braunstein, Bjoern},
  title     = {Differences between take-off behavior during vertical jumps and two artistic elements},
  series = {34th International Conference of Biomechanics in Sport, Tsukuba, Japan, July 18-22, 2016},
  booktitle = {34th International Conference of Biomechanics in Sport, Tsukuba, Japan, July 18-22, 2016},
  issn      = {1999-4168},
  pages     = {577 -- 580},
  year      = {2016},
  language  = {en}
}
@inproceedings{GoldmannBraunsteinHeinrichetal.2015,
  author    = {Goldmann, Jan-Peter and Braunstein, Bjoern and Heinrich, Kai and Sanno, Maximilian and St{\"a}udle, Benjamin and Ritzdorf, Wolfgang and Br{\"u}ggemann, Gert-Peter and Albracht, Kirsten},
  title     = {Joint work of the take-off leg during elite high jump},
  series = {Proceedings of the 33th International Conference on Biomechanics in Sports (ISBS)},
  booktitle = {Proceedings of the 33th International Conference on Biomechanics in Sports (ISBS)},
  pages     = {3 S.},
  year      = {2015},
  language  = {en}
}
@article{ZangeSchopenAlbrachtetal.2017,
  author    = {Zange, Jochen and Schopen, Kathrin and Albracht, Kirsten and Gerlach, Darius A. and Frings-Meuthen, Petra and Maffiuletti, Nicola A. and Bloch, Wilhelm and Rittweger, J{\"o}rn},
  title     = {Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial},
  series = {Plos one},
  volume    = {12},
  journal   = {Plos one},
  number    = {2},
  doi       = {10.1371/journal.pone.0171562},
  year      = {2017},
  language  = {en}
}
@inproceedings{KolditzAlbinFasseetal.2015,
  author    = {Kolditz, Melanie and Albin, Thivaharan and Fasse, Alessandro and Br{\"u}ggemann, Gert-Peter and Abel, Dirk and Albracht, Kirsten},
  title     = {Simulative Analysis of Joint Loading During Leg Press Exercise for Control Applications},
  series = {IFAC-PapersOnLine},
  volume    = {48},
  booktitle = {IFAC-PapersOnLine},
  number    = {20},
  doi       = {10.1016/j.ifacol.2015.10.179},
  pages     = {435 -- 440},
  year      = {2015},
  language  = {en}
}
@inproceedings{KolditzAlbrachtFasseetal.2015,
  author    = {Kolditz, Melanie and Albracht, Kirsten and Fasse, Alessandro and Albin, Thivaharan and Br{\"u}ggemann, Gert-Peter and Abel, Dirk},
  title     = {Evaluation of an industrial robot as a leg press training device},
  series = {XV International Symposium on Computer Simulation in Biomechanics July 9th - 11th 2015, Edinburgh, UK},
  booktitle = {XV International Symposium on Computer Simulation in Biomechanics July 9th - 11th 2015, Edinburgh, UK},
  pages     = {41 -- 42},
  year      = {2015},
  language  = {en}
}
@phdthesis{Albracht2010,
  author    = {Albracht, Kirsten},
  title     = {Influence of mechanical properties of the leg extensor muscletendon units on running economy},
  publisher = {Deutsche Sporthochschule K{\"o}ln},
  address   = {K{\"o}ln},
  pages     = {X, 1221 Bl. : graph. Darst.},
  year      = {2010},
  language  = {en}
}
@article{HacklWegmannKahmannetal.2017,
  author    = {Hackl, Michael and Wegmann, Kilian and Kahmann, Stephanie Lucina and Heinze, Nicolai and Staat, Manfred and Neiss, Wolfram F. and Scaal, Martin and M{\"u}ller, Lars P.},
  title     = {Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow},
  series = {Knee Surgery, Sports Traumatology, Arthroscopy},
  volume    = {25},
  journal   = {Knee Surgery, Sports Traumatology, Arthroscopy},
  number    = {7},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1433-7347},
  doi       = {10.1007/s00167-017-4468-z},
  pages     = {2280 -- 2288},
  year      = {2017},
  language  = {en}
}
@article{PoghossianWernerBuniatyanetal.2017,
  author    = {Poghossian, Arshak and Werner, Frederik and Buniatyan, V. V. and Wagner, Torsten and Miamoto, K. and Yoshinobu, T. and Sch{\"o}ning, Michael Josef},
  title     = {Towards addressability of light-addressable potentiometric sensors: Shunting effect of non-illuminated region and cross-talk},
  series = {Sensor and Actuators B: Chemical},
  journal   = {Sensor and Actuators B: Chemical},
  number    = {244},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2017.01.047},
  pages     = {1071 -- 1079},
  year      = {2017},
  abstract  = {The LAPS (light-addressable potentiometric sensor) platform is one of the most attractive approaches for chemical and biological sensing with many applications ranging from pH and ion/analyte concentration measurements up to cell metabolism detection and chemical imaging. However, although it is generally accepted that LAPS measurements are spatially resolved, the light-addressability feature of LAPS devices has not been discussed in detail so far. In this work, an extended electrical equivalent-circuit model of the LAPS has been presented, which takes into account possible cross-talk effects due to the capacitive coupling of the non-illuminated region. A shunting effect of the non-illuminated area on the measured photocurrent and addressability of LAPS devices has been studied. It has been shown, that the measured photocurrent will be determined not only by the local interfacial potential in the illuminated region but also by possible interfacial potential changes in the non-illuminated region, yielding cross-talk effects. These findings were supported by the experimental investigations of a penicillin-sensitive multi-spot LAPS and a metal-insulator-semiconductor LAPS as model systems.},
  language  = {en}
}
@article{JahnkeRousselHombachetal.2016,
  author    = {Jahnke, Siegfried and Roussel, Johanna and Hombach, Thomas and Kochs, Johannes and Fischbach, Andreas and Huber, Gregor and Scharr, Hanno},
  title     = {phenoSeeder - A robot system for automated handling and phenotyping of individual seeds},
  series = {Plant physiology},
  volume    = {172},
  journal   = {Plant physiology},
  number    = {3},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {0032-0889},
  doi       = {10.1104/pp.16.01122},
  pages     = {1358 -- 1370},
  year      = {2016},
  abstract  = {The enormous diversity of seed traits is an intriguing feature and critical for the overwhelming success of higher plants. In particular, seed mass is generally regarded to be key for seedling development but is mostly approximated by using scanning methods delivering only two-dimensional data, often termed seed size. However, three-dimensional traits, such as the volume or mass of single seeds, are very rarely determined in routine measurements. Here, we introduce a device named phenoSeeder, which enables the handling and phenotyping of individual seeds of very different sizes. The system consists of a pick-and-place robot and a modular setup of sensors that can be versatilely extended. Basic biometric traits detected for individual seeds are two-dimensional data from projections, three-dimensional data from volumetric measures, and mass, from which seed density is also calculated. Each seed is tracked by an identifier and, after phenotyping, can be planted, sorted, or individually stored for further evaluation or processing (e.g. in routine seed-to-plant tracking pipelines). By investigating seeds of Arabidopsis (Arabidopsis thaliana), rapeseed (Brassica napus), and barley (Hordeum vulgare), we observed that, even for apparently round-shaped seeds of rapeseed, correlations between the projected area and the mass of seeds were much weaker than between volume and mass. This indicates that simple projections may not deliver good proxies for seed mass. Although throughput is limited, we expect that automated seed phenotyping on a single-seed basis can contribute valuable information for applications in a wide range of wild or crop species, including seed classification, seed sorting, and assessment of seed quality.},
  language  = {en}
}
@inproceedings{PoghossianBronderSchejaetal.2016,
  author    = {Poghossian, Arshak and Bronder, Thomas and Scheja, S. and Wu, Chunsheng and Metzger-Boddien, C. and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Label-free Electrostatic Detection of DNA Amplification by PCR Using Capacitive Field-effect Devices},
  series = {Procedia Engineering},
  volume    = {Vol. 168},
  booktitle = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2016.11.512},
  pages     = {514 -- 517},
  year      = {2016},
  abstract  = {A capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor modified with a positively charged weak polyelectrolyte of poly(allylamine hydrochloride) (PAH)/single-stranded probe DNA (ssDNA) bilayer has been used for a label-free electrostatic detection of pathogen-specific DNA amplification via polymerase chain reaction (PCR). The sensor is able to distinguish between positive and negative PCR solutions, to detect the existence of target DNA amplicons in PCR samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process.},
  language  = {en}
}
@article{KatzPoghossianSchoening2017,
  author    = {Katz, Evgeny and Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics},
  series = {Analytical and Bioanalytical Chemistry},
  volume    = {409},
  journal   = {Analytical and Bioanalytical Chemistry},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1618-2650},
  doi       = {10.1007/s00216-016-0079-7},
  pages     = {81 -- 94},
  year      = {2017},
  abstract  = {The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a "filter" system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion.},
  language  = {en}
}
@inproceedings{BaeckerKochGeigeretal.2016,
  author    = {B{\"a}cker, Matthias and Koch, C. and Geiger, F. and Eber, F. and Gliemann, H. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {A New Class of Biosensors Based on Tobacco Mosaic Virus and Coat Proteins as Enzyme Nanocarrier},
  series = {Procedia Engineering},
  volume    = {Vol. 168},
  booktitle = {Procedia Engineering},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2016.11.228},
  pages     = {618 -- 621},
  year      = {2016},
  language  = {en}
}
@article{AlbrachtArampatzis2006,
  author    = {Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy},
  series = {Biological Cybernetics},
  volume    = {95},
  journal   = {Biological Cybernetics},
  number    = {1},
  issn      = {1432-0770},
  doi       = {10.1007/s00422-006-0070-z},
  pages     = {87 -- 96},
  year      = {2006},
  language  = {en}
}
@article{ArampatzisKaramanidisAlbracht2007,
  author    = {Arampatzis, Adamantios and Karamanidis, Kiros and Albracht, Kirsten},
  title     = {Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude},
  series = {Journal of Experimental Biology},
  volume    = {210},
  journal   = {Journal of Experimental Biology},
  number    = {15},
  issn      = {0022-0949},
  doi       = {10.1242/jeb.003814},
  pages     = {2743 -- 2753},
  year      = {2007},
  language  = {en}
}
@article{AlbrachtArampatzisBaltzopoulos2008,
  author    = {Albracht, Kirsten and Arampatzis, A. and Baltzopoulos, V.},
  title     = {Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivo},
  series = {Journal of Biomechanics},
  volume    = {41},
  journal   = {Journal of Biomechanics},
  issn      = {0021-9290},
  doi       = {10.1016/j.jbiomech.2008.04.020},
  pages     = {2211 -- 2218},
  year      = {2008},
  language  = {en}
}
@article{ArampatzisKaramanidisMademlietal.2009,
  author    = {Arampatzis, Adamantios and Karamanidis, Kiros and Mademli, Lida and Albracht, Kirsten},
  title     = {Plasticity of the human tendon to short and long-term mechanical loading},
  series = {Exercise and Sport Sciences Reviews},
  volume    = {37},
  journal   = {Exercise and Sport Sciences Reviews},
  number    = {2},
  issn      = {1538-3008},
  doi       = {10.1097/JES.0b013e31819c2e1d},
  pages     = {66 -- 72},
  year      = {2009},
  language  = {en}
}
@article{AggeloussisGiannakouAlbrachtetal.2010,
  author    = {Aggeloussis, Nickos and Giannakou, Erasmia and Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Reproducibility of fascicle length and pennation angle of gastrocnemius medialis in human gait in vivo},
  series = {Gait and Posture},
  volume    = {31},
  journal   = {Gait and Posture},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0966-6362},
  doi       = {10.1016/j.gaitpost.2009.08.249},
  pages     = {73 -- 77},
  year      = {2010},
  abstract  = {The purpose of the current study was to examine the reproducibility of fascicle length and pennation angle of gastrocnemius medialis while human walking. To the best of our knowledge, this is the first study of the reproducibility of fascicle length and pennation angle of gastrocnemius medialis in vivo during human gait. Twelve males performed 10 gait trials on a treadmill, in 2 separate days. B-mode ultrasonography, with the ultrasound probe firmly adjusted in the transverse and frontal planes using a special cast, was used to measure the fascicle length and the pennation angle of the gastrocnemius medialis (GM). A Vicon 624 system with three cameras operating at 120 Hz was also used to record the ankle and knee joint angles. The results showed that measurements of fascicle length and pennation angle showed high reproducibility during the gait cycle, both within the same day and between different days. Moreover, the root mean square differences between the repeated waveforms of both variables were very small, compared with their ranges (fascicle length: RMS = ∼3 mm, range: 38-63 mm; pennation angle: RMS = ∼1.5°, range: 22-32°). However, their reproducibility was lower compared to the joint angles. It was found that representative data have to be derived by a wide number of gait trials (fascicle length ∼six trials, pennation angle more than 10 trials), to assure the reliability of the fascicle length and pennation angle in human gait.},
  language  = {en}
}
@article{ArampatzisPeperBierbaumetal.2010,
  author    = {Arampatzis, Adamantios and Peper, Andreas and Bierbaum, Stefanie and Albracht, Kirsten},
  title     = {Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain},
  series = {Journal of Biomechanics},
  volume    = {43},
  journal   = {Journal of Biomechanics},
  number    = {16},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0021-9290},
  doi       = {10.1016/j.jbiomech.2010.08.014},
  pages     = {3073 -- 3079},
  year      = {2010},
  abstract  = {The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47\%), and the other leg at high tendon strain magnitude (4.72±1.08\%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon-aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon-aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.},
  language  = {en}
}
@article{KaramanidisAlbrachtBraunsteinetal.2011,
  author    = {Karamanidis, Kiros and Albracht, Kirsten and Braunstein, Bjoern and Catala, Maria Moreno and Goldmann, Jan-Peter and Br{\"u}ggemann, Gert-Peter},
  title     = {Lower leg musculoskeletal geometry and sprint performance},
  series = {Gait and Posture},
  volume    = {34},
  journal   = {Gait and Posture},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0966-6362},
  doi       = {10.1016/j.gaitpost.2011.03.009},
  pages     = {138 -- 141},
  year      = {2011},
  abstract  = {The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components.},
  language  = {en}
}
@article{AlbrachtArampatzis2013,
  author    = {Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans},
  series = {European Journal of Applied Physiology},
  volume    = {113},
  journal   = {European Journal of Applied Physiology},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1439-6327},
  doi       = {10.1007/s00421-012-2585-4},
  pages     = {1605 -- 1615},
  year      = {2013},
  language  = {en}
}
@article{SeynnesBojsenMollerAlbrachtetal.2015,
  author    = {Seynnes, O. R. and Bojsen-Moller, J. and Albracht, Kirsten and Arndt, A. and Cronin, N. J. and Finni, T. and Magnusson, S. P.},
  title     = {Ultrasound-based testing of tendon mechanical properties: a critical evaluation},
  series = {Journal of Applied Physiology},
  volume    = {118},
  journal   = {Journal of Applied Physiology},
  number    = {2},
  issn      = {8750-7587},
  doi       = {10.1152/japplphysiol.00849.2014},
  pages     = {133 -- 141},
  year      = {2015},
  language  = {en}
}
@article{BelavyAlbrachtBruggemannetal.2016,
  author    = {Belavy, Daniel L. and Albracht, Kirsten and Bruggemann, Gert-Peter and Vergroesen, Pieter-Paul A. and Dieen, Jaap H. van},
  title     = {Can exercise positively influence the intervertebral disc?},
  series = {Sports Medicine},
  volume    = {46},
  journal   = {Sports Medicine},
  number    = {4},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1179-2035},
  doi       = {10.1007/s40279-015-0444-2},
  pages     = {473 -- 485},
  year      = {2016},
  abstract  = {To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a 'critical period' for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research.},
  language  = {en}
}
@article{KolditzAlbinAbeletal.2016,
  author    = {Kolditz, Melanie and Albin, Thivaharan and Abel, Dirk and Fasse, Alessandro and Br{\"u}ggemann, Gert-Peter and Albracht, Kirsten},
  title     = {Evaluation of foot position and orientation as manipulated variables to control external knee adduction moments in leg extension training},
  series = {Computer methods and programs in biomedicine},
  volume    = {171},
  journal   = {Computer methods and programs in biomedicine},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0169-2607},
  doi       = {10.1016/j.cmpb.2016.09.005},
  pages     = {81 -- 86},
  year      = {2016},
  abstract  = {Background and Objective Effective leg extension training at a leg press requires high forces, which need to be controlled to avoid training-induced damage. In order to avoid high external knee adduction moments, which are one reason for unphysiological loadings on knee joint structures, both training movements and the whole reaction force vector need to be observed. In this study, the applicability of lateral and medial changes in foot orientation and position as possible manipulated variables to control external knee adduction moments is investigated. As secondary parameters both the medio-lateral position of the center of pressure and the frontal-plane orientation of the reaction force vector are analyzed. Methods Knee adduction moments are estimated using a dynamic model of the musculoskeletal system together with the measured reaction force vector and the motion of the subject by solving the inverse kinematic and dynamic problem. Six different foot conditions with varying positions and orientations of the foot in a static leg press are evaluated and compared to a neutral foot position. Results Both lateral and medial wedges under the foot and medial and lateral shifts of the foot can influence external knee adduction moments in the presented study with six healthy subjects. Different effects are observed with the varying conditions: the pose of the leg is changed and the direction and center of pressure of the reaction force vector is influenced. Each effect results in a different direction or center of pressure of the reaction force vector. Conclusions The results allow the conclusion that foot position and orientation can be used as manipulated variables in a control loop to actively control knee adduction moments in leg extension training.},
  language  = {en}
}
@article{Staat2012,
  author    = {Staat, Manfred},
  title     = {Limit and shakedown analysis under uncertainty},
  series = {Tap chi Khoa hoc \& ung dung - Dai hoc Ton Duc Thang},
  volume    = {19},
  journal   = {Tap chi Khoa hoc \& ung dung - Dai hoc Ton Duc Thang},
  pages     = {45 -- 47},
  year      = {2012},
  language  = {en}
}
@article{LeversStaatLaack2016,
  author    = {Levers, A. and Staat, Manfred and Laack, Walter van},
  title     = {Analysis of the long-term effect of the MBST® nuclear magnetic resonance therapy on gonarthrosis},
  series = {Orthopedic Practice},
  volume    = {47},
  journal   = {Orthopedic Practice},
  number    = {11},
  pages     = {521 -- 528},
  year      = {2016},
  language  = {en}
}
@inproceedings{TranTranMatthiesetal.2016,
  author    = {Tran, Ngoc Trinh and Tran, Thanh Ngoc and Matthies, Hermann G. and Stavroulakis, Georgios Eleftherios and Staat, Manfred},
  title     = {FEM Shakedown of uncertain structures by chance constrained programming},
  series = {PAMM Proceedings in Applied Mathematics and Mechanics},
  volume    = {16},
  booktitle = {PAMM Proceedings in Applied Mathematics and Mechanics},
  number    = {1},
  issn      = {1617-7061},
  doi       = {10.1002/pamm.201610346},
  pages     = {715 -- 716},
  year      = {2016},
  language  = {en}
}
@inproceedings{BhattaraiFrotscherStaat2016,
  author    = {Bhattarai, Aroj and Frotscher, Ralf and Staat, Manfred},
  title     = {Significance of fibre geometry on passive-active response of pelvic muscles to evaluate pelvic dysfunction},
  series = {BioMedWomen: Proceedings of the international conference on clinical and bioengineering for women's health},
  booktitle = {BioMedWomen: Proceedings of the international conference on clinical and bioengineering for women's health},
  editor    = {Natal Jorge, Renato},
  publisher = {CRC Press},
  address   = {Boca Raton},
  isbn      = {978-1-138-02910-1},
  pages     = {185 -- 188},
  year      = {2016},
  language  = {en}
}
@article{HacklAndermahrStaatetal.2017,
  author    = {Hackl, M. and Andermahr, J. and Staat, Manfred and Bremer, I. and Borggrefe, J. and Prescher, A. and M{\"u}ller, L. P. and Wegmann, K.},
  title     = {Suture button reconstruction of the central band of the interosseous membrane in Essex-Lopresti lesions: a comparative biomechanical investigation},
  series = {The Journal of Hand Surgery (European Volume)},
  volume    = {42},
  journal   = {The Journal of Hand Surgery (European Volume)},
  number    = {4},
  publisher = {Sage},
  address   = {London},
  issn      = {2043-6289 (Online)},
  doi       = {10.1177/1753193416665943},
  pages     = {370 -- 376},
  year      = {2017},
  language  = {en}
}
@article{AlbannaConzenWeissetal.2016,
  author    = {Albanna, W. and Conzen, C. and Weiss, M. and Clusmann, H. and Fuest, M. and Mueller, M. and Brockmann, M.A. and Vilser, W. and Schmidt-Trucks{\"a}ss, A. and Hoellig, A. and Seiz, M. and Thom{\´e}, C. and Kotliar, Konstantin and Schubert, G.A.},
  title     = {Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study},
  series = {PLoS ONE},
  volume    = {11},
  journal   = {PLoS ONE},
  number    = {7},
  publisher = {PLOS},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0158781},
  pages     = {13 Seiten},
  year      = {2016},
  abstract  = {Background Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. Methods In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2-14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling. Results Image quality was satisfactory in the majority of cases (93.3\%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion. Conclusion RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.},
  language  = {en}
}
@article{BaeckerKochEibenetal.2017,
  author    = {B{\"a}cker, Matthias and Koch, Claudia and Eiben, Sabine and Geiger, Fania and Eber, Fabian and Gliemann, Hartmut and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef},
  title     = {Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors},
  series = {Sensors and Actuators B: Chemical},
  volume    = {238},
  journal   = {Sensors and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.07.096},
  pages     = {716 -- 722},
  year      = {2017},
  abstract  = {The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.},
  language  = {en}
}
@inproceedings{TranTranMatthiesetal.2016,
  author    = {Tran, Ngoc Trinh and Tran, Thanh Ngoc and Matthies, H. G. and Stavroulakis, G. E. and Staat, Manfred},
  title     = {Shakedown analysis of plate bending analysis under stochastic uncertainty by chance constrained programming},
  series = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016},
  booktitle = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016},
  editor    = {Papadrakakis, M.},
  pages     = {13 S.},
  year      = {2016},
  language  = {en}
}
@article{MolinnusSorichBartzetal.2016,
  author    = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate},
  series = {Sensors and Actuators B: Chemical},
  volume    = {237},
  journal   = {Sensors and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.06.064},
  pages     = {190 -- 195},
  year      = {2016},
  abstract  = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.},
  language  = {en}
}
@article{KnobeGiesenPlateetal.2016,
  author    = {Knobe, M. and Giesen, M. and Plate, S. and Gradl-Dietsch, G. and Buecking, B. and Eschbach, D. and Laack, Walter van and Pape, H.-C.},
  title     = {The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale},
  series = {European Journal Of Trauma And Emergency Surgery},
  volume    = {42},
  journal   = {European Journal Of Trauma And Emergency Surgery},
  number    = {5},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1863-9941},
  doi       = {10.1007/s00068-016-0693-2},
  pages     = {537 -- 545},
  year      = {2016},
  abstract  = {Purpose The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. Methods For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland-Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. Results The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = -0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points). Conclusion The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status.},
  language  = {en}
}
@article{DollWagnerWagneretal.2016,
  author    = {Doll, Theodor and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Sch{\"o}ning (eds.)},
  series = {Physica status solidi (a)},
  volume    = {213},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201670641},
  pages     = {1393 -- 1394},
  year      = {2016},
  language  = {en}
}
@article{WagnerVornholtWerneretal.2016,
  author    = {Wagner, Torsten and Vornholt, Wolfgang and Werner, Frederik and Yoshinobu, Tatsuo and Miyamoto, Ko-Ichiro and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening},
  series = {Physics in medicine},
  volume    = {2016},
  journal   = {Physics in medicine},
  number    = {1},
  issn      = {2352-4510},
  doi       = {10.1016/j.phmed.2016.03.001},
  pages     = {2 -- 7},
  year      = {2016},
  abstract  = {The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.},
  language  = {en}
}
@article{MiyamotoSatoAbeetal.2016,
  author    = {Miyamoto, Ko-Ichiro and Sato, Takuya and Abe, Minami and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices},
  series = {Micromachines},
  volume    = {7},
  journal   = {Micromachines},
  number    = {7},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-666X},
  doi       = {10.3390/mi7070111},
  pages     = {111},
  year      = {2016},
  abstract  = {A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.},
  language  = {en}
}
@inproceedings{SchreiberKraftZuendorf2016,
  author    = {Schreiber, Marc and Kraft, Bodo and Z{\"u}ndorf, Albert},
  title     = {Cost-efficient quality assurance of natural language processing tools through continuous monitoring with continuous integration},
  series = {3rd International Workshop on Software Engineering Research and Industrial Practice},
  booktitle = {3rd International Workshop on Software Engineering Research and Industrial Practice},
  doi       = {10.1145/2897022.2897029},
  pages     = {46 -- 52},
  year      = {2016},
  language  = {en}
}
@article{WegmannHacklStaatetal.2016,
  author    = {Wegmann, Kilian and Hackl, Michael and Staat, Manfred and Mayer, Katharina and M{\"u}ller, Lars-Peter},
  title     = {Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results},
  series = {Knee surgery, sports traumatology, arthroscopy},
  volume    = {Volume 24},
  journal   = {Knee surgery, sports traumatology, arthroscopy},
  number    = {Supplement 1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0942-2056},
  doi       = {10.1007/s00167-016-4079-0},
  pages     = {58 -- 59},
  year      = {2016},
  abstract  = {While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates.},
  language  = {en}
}
@article{HacklLeschingerStaatetal.2016,
  author    = {Hackl, Michael and Leschinger, T. and Staat, Manfred and M{\"u}ller, Lars-Peter and Wegmann, Kilian},
  title     = {Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation},
  series = {Knee surgery, sports traumatology, arthroscopy},
  volume    = {Volume 24},
  journal   = {Knee surgery, sports traumatology, arthroscopy},
  number    = {Supplement 1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0942-2056},
  doi       = {10.1007/s00167-016-4080-7},
  pages     = {130 -- 131},
  year      = {2016},
  abstract  = {Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique.},
  language  = {en}
}
@article{HacklKahmannWegmannetal.2016,
  author    = {Hackl, Michael and Kahmann, Stephanie Lucina and Wegmann, Kilian and Ries, Christian and Staat, Manfred and M{\"u}ller, Lars-Peter},
  title     = {Shortening osteotomy of the proximal radius — a treatment option for isolated osteoarthritis of the lateral column of the elbow joint?},
  series = {Knee surgery, sports traumatology, arthroscopy},
  volume    = {Volume 24},
  journal   = {Knee surgery, sports traumatology, arthroscopy},
  number    = {Supplement 1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0942-2056},
  doi       = {10.1007/s00167-016-4080-7},
  pages     = {128 -- 129},
  year      = {2016},
  abstract  = {Treatment of posttraumatic osteoarthritis of the radial column of the elbow joint remains a challenging yet common issue. While partial joint replacement leads to high revision rates, radial head excision has shown to severely increase joint instability. Shortening osteotomy of the radius could be an option to decrease the contact pressure of the radiohumeral joint and thereby pain levels without causing valgus instability. Hence, the aim of this biomechanical study was to evaluate the effects of radial shortening on axial load distribution and valgus stability of the elbow joint.},
  language  = {en}
}
@article{HacklMuellerStaatetal.2016,
  author    = {Hackl, Michael and M{\"u}ller, Lars-Peter and Staat, Manfred and Kahmann, Stephanie Lucina and Wegmann, Kilian},
  title     = {Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques},
  series = {Knee surgery, sports traumatology, arthroscopy},
  volume    = {Volume 24},
  journal   = {Knee surgery, sports traumatology, arthroscopy},
  number    = {Supplement 1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0942-2056},
  doi       = {10.1007/s00167-016-4080-7},
  pages     = {148 -- 149},
  year      = {2016},
  abstract  = {Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.},
  language  = {en}
}
@inproceedings{KahmannHacklWegmannetal.2016,
  author    = {Kahmann, Stephanie and Hackl, Michael and Wegmann, Kilian and M{\"u}ller, Lars-Peter and Staat, Manfred},
  title     = {Impact of a proximal radial shortening osteotomy on the distribution of forces and the stability of the elbow},
  series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen},
  booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen},
  editor    = {Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  doi       = {10.17185/duepublico/40821},
  pages     = {7 -- 8},
  year      = {2016},
  abstract  = {The human arm consists of the humerus (upper arm), the medial ulna and the lateral radius (forearm). The joint between the humerus and the ulna is called humeroulnar joint and the joint between the humerus and the radius is called humeroradial joint. Lateral and medial collateral ligaments stabilize the elbow. Statistically, 2.5 out of 10,000 people suffer from radial head fractures [1]. In these fractures the cartilage is often affected. Caused by the injured cartilage, degenerative diseases like posttraumatic arthrosis may occur. The resulting pain and reduced range of motion have an impact on the patient's quality of life. Until now, there has not been a treatment which allows typical loads in daily life activities and offers good long-term results. A new surgical approach was developed with the motivation to reduce the progress of the posttraumatic arthrosis. Here, the radius is shortened by 3 mm in the proximal part [2]. By this means, the load of the radius is intended to be reduced due to a load shift to the ulna. Since the radius is the most important stabilizer of the elbow it has to be confirmed that the stability is not affected. In the first test (Fig. 1 left), pressure distributions within the humeroulnar and humeroradial joints a native and a shortened radius were measured using resistive pressure sensors (I5076 and I5027, Tekscan, USA). The humerus was loaded axially in a tension testing machine (Z010, Zwick Roell, Germany) in 50 N steps up to 400 N. From the humerus the load is transmitted through both the radius and the ulna into the hand which is fixed on the ground. In the second test (Fig. 1 right), the joint stability was investigated using a digital image correlation system to measure the displacement of the ulna. Here, the humerus is fixed with a desired flexion angle and the unconstrained forearm lies on the ground. A rope connects the load actuator with a hook fixed in the ulna. A guide roller is used so that the rope pulls the ulna horizontally when a tensile load is applied. This creates a moment about the elbow joint with a maximum value of 7.5 Nm. Measurements were performed with varying flexion angles (0°, 30°, 60°, 90°, 120°). For both tests and each measurement, seven specimens were used. Student's t-test was employed to determine whether the mean values of the measurements in native specimen and operated specimens differ significantly.},
  language  = {en}
}
@inproceedings{JungStaat2016,
  author    = {Jung, Alexander and Staat, Manfred},
  title     = {Computing olympic gold: Ski jumping as an example},
  series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen},
  booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen},
  editor    = {Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-940402-06-6},
  doi       = {10.17185/duepublico/40821},
  pages     = {54 -- 55},
  year      = {2016},
  language  = {en}
}
@inproceedings{BhattaraiStaat2016,
  author    = {Bhattarai, Aroj and Staat, Manfred},
  title     = {Female pelvic floor dysfunction: progress weakening of the support system},
  series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen},
  booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen},
  editor    = {Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  doi       = {10.17185/duepublico/40821},
  pages     = {11 -- 12},
  year      = {2016},
  abstract  = {The structure of the female pelvic floor (PF) is an inter-related system of bony pelvis,muscles, pelvic organs, fascias, ligaments, and nerves with multiple functions. Mechanically, thepelvic organ support system are of two types: (I) supporting system of the levator ani (LA) muscle,and (II) the suspension system of the endopelvic fascia condensation [1], [2]. Significantdenervation injury to the pelvic musculature, depolimerization of the collagen fibrils of the softvaginal hammock, cervical ring and ligaments during pregnancy and vaginal delivery weakens thenormal functions of the pelvic floor. Pelvic organ prolapse, incontinence, sexual dysfunction aresome of the dysfunctions which increases progressively with age and menopause due toweakened support system according to the Integral theory [3]. An improved 3D finite elementmodel of the female pelvic floor as shown in Fig. 1 is constructed that: (I) considers the realisticsupport of the organs to the pelvic side walls, (II) employs the improvement of our previous FEmodel [4], [5] along with the patient based geometries, (III) incorporates the realistic anatomy andboundary conditions of the endopelvic (pubocervical and rectovaginal) fascia, and (IV) considersvarying stiffness of the endopelvic fascia in the craniocaudal direction [3]. Several computationsare carried out on the presented computational model with healthy and damaged supportingtissues, and comparisons are made to understand the physiopathology of the female PF disorders.},
  language  = {en}
}
@article{PookhalilAmoabedinyTabeshetal.2016,
  author    = {Pookhalil, Ali and Amoabediny, Ghassem and Tabesh, Hadi and Behbahani, Mehdi and Mottaghy, Khosrow},
  title     = {A new approach for semiempirical modeling of mechanical blood trauma},
  series = {The international journal of artificial organs},
  volume    = {39},
  journal   = {The international journal of artificial organs},
  number    = {4},
  publisher = {Sage},
  address   = {London},
  issn      = {1724-6040},
  doi       = {10.5301/ijao.5000474},
  pages     = {171 -- 177},
  year      = {2016},
  abstract  = {Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.},
  language  = {en}
}
@article{BreuerRaueStrobeletal.2016,
  author    = {Breuer, Lars and Raue, Markus and Strobel, M. and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, R. and Wagner, Torsten},
  title     = {Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems},
  series = {Physica status solidi (a)},
  volume    = {213},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300},
  doi       = {10.1002/pssa.201533056},
  pages     = {1520 -- 1525},
  year      = {2016},
  abstract  = {Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium.},
  language  = {en}
}
@article{DantismTakenagaWagneretal.2016,
  author    = {Dantism, Shahriar and Takenaga, Shoko and Wagner, Patrick and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system},
  series = {Physica status solidi (a)},
  volume    = {213},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300},
  doi       = {10.1002/pssa.201533043},
  pages     = {1479 -- 1485},
  year      = {2016},
  abstract  = {On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable "down times" during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements.},
  language  = {en}
}
@article{WuPoghossianBronderetal.2016,
  author    = {Wu, Chunsheng and Poghossian, Arshak and Bronder, Thomas and Sch{\"o}ning, Michael Josef},
  title     = {Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor},
  series = {Sensors and Actuators B: Chemical},
  journal   = {Sensors and Actuators B: Chemical},
  number    = {229},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.02.004},
  pages     = {506 -- 512},
  year      = {2016},
  abstract  = {A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules.},
  language  = {en}
}
@article{ArreolaMaetzkowDuranetal.2016,
  author    = {Arreola, Julio and M{\"a}tzkow, Malte and Dur{\´a}n, Marlena Palomar and Greeff, Anton and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Optimization of the immobilization of bacterial spores on glass substrates with organosilanes},
  series = {Physica status solidi (A) : Applications and materials science},
  volume    = {213},
  journal   = {Physica status solidi (A) : Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201532914},
  pages     = {1463 -- 1470},
  year      = {2016},
  abstract  = {Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.},
  language  = {en}
}
@inproceedings{KremersPieper2015,
  author    = {Kremers, Alexander and Pieper, Martin},
  title     = {Simulation and Verification of Bionic Heat Exchangers with COMSOL Multiphysics® Software},
  series = {COMSOL Conference 2015 User Presentations ; COMSOL Conference 2015 Grenoble October 14 - 16, 2015 - World Trade Center, Grenoble, France},
  booktitle = {COMSOL Conference 2015 User Presentations ; COMSOL Conference 2015 Grenoble October 14 - 16, 2015 - World Trade Center, Grenoble, France},
  publisher = {COMSOL},
  address   = {G{\"o}ttingen ; Berlin},
  pages     = {6 Seiten},
  year      = {2015},
  language  = {en}
}
@article{DiktaReisselHarlass2016,
  author    = {Dikta, Gerhard and Reißel, Martin and Harlaß, Carsten},
  title     = {Semi-parametric survival function estimators deduced from an identifying Volterra type integral equation},
  series = {Journal of multivariate analysis},
  journal   = {Journal of multivariate analysis},
  number    = {147},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.jmva.2016.02.008},
  pages     = {273 -- 284},
  year      = {2016},
  abstract  = {Based on an identifying Volterra type integral equation for randomly right censored observations from a lifetime distribution function F, we solve the corresponding estimating equation by an explicit and implicit Euler scheme. While the first approach results in some known estimators, the second one produces new semi-parametric and pre-smoothed Kaplan-Meier estimators which are real distribution functions rather than sub-distribution functions as the former ones are. This property of the new estimators is particular useful if one wants to estimate the expected lifetime restricted to the support of the observation time. Specifically, we focus on estimation under the semi-parametric random censorship model (SRCM), that is, a random censorship model where the conditional expectation of the censoring indicator given the observation belongs to a parametric family. We show that some estimated linear functionals which are based on the new semi-parametric estimator are strong consistent, asymptotically normal, and efficient under SRCM. In a small simulation study, the performance of the new estimator is illustrated under moderate sample sizes. Finally, we apply the new estimator to a well-known real dataset.},
  language  = {en}
}
@inproceedings{JungStaatMueller2016,
  author    = {Jung, Alexander and Staat, Manfred and M{\"u}ller, Wolfram},
  title     = {Effect of wind on flight style optimisation in ski jumping},
  series = {15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK},
  booktitle = {15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK},
  publisher = {The University of Edinburgh ; Loughborough University},
  address   = {Edinburgh},
  pages     = {53 -- 54},
  year      = {2016},
  language  = {en}
}
@article{FrotscherMuanghongDursunetal.2016,
  author    = {Frotscher, Ralf and Muanghong, Danita and Dursun, G{\"o}zde and Goßmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Staat, Manfred},
  title     = {Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue},
  series = {Journal of Biomechanics},
  volume    = {49},
  journal   = {Journal of Biomechanics},
  number    = {12},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0021-9290 (Print)},
  doi       = {10.1016/j.jbiomech.2016.01.039},
  pages     = {2428 -- 2435},
  year      = {2016},
  abstract  = {We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.},
  language  = {en}
}
@article{GossmannFrotscherLinderetal.2016,
  author    = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells},
  series = {Cellular physiology and biochemistry},
  volume    = {38},
  journal   = {Cellular physiology and biochemistry},
  number    = {3},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1421-9778 (Online)},
  doi       = {10.1159/000443124},
  pages     = {1182 -- 1198},
  year      = {2016},
  abstract  = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.},
  language  = {en}
}
@article{FischerSelverGezeretal.2015,
  author    = {Fischer, Felix and Selver, M. Alper and Gezer, Sinem and Dicle, Oguz and Hillen, Walter},
  title     = {Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data},
  series = {Journal of Medical and Biological Engineering},
  volume    = {35},
  journal   = {Journal of Medical and Biological Engineering},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {2199-4757},
  doi       = {10.1007/s40846-015-0097-5},
  pages     = {709 -- 723},
  year      = {2015},
  language  = {en}
}
@inproceedings{PoghossianBronderWuetal.2015,
  author    = {Poghossian, Arshak and Bronder, Thomas and Wu, Chunsheng and Sch{\"o}ning, Michael Josef},
  title     = {Label-free sensing of biomolecules by their intrinsic molecular charge using field-effect devices},
  series = {Semiconductor Micro- and Nanoelectonics : Proceedings of the tenth international conference, Yerevan, Armenia, September 11-13},
  booktitle = {Semiconductor Micro- and Nanoelectonics : Proceedings of the tenth international conference, Yerevan, Armenia, September 11-13},
  isbn      = {978-5-8084-1991-9},
  pages     = {61 -- 63},
  year      = {2015},
  language  = {en}
}
@article{HamadBilattoAdlyetal.2016,
  author    = {Hamad, E. M. and Bilatto, S. E. R. and Adly, N. Y. and Correa, D. S. and Wolfrum, B. and Sch{\"o}ning, Michael Josef and Offenh{\"a}usser, A. and Yakushenko, A.},
  title     = {Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices},
  series = {Lab on a Chip},
  volume    = {16},
  journal   = {Lab on a Chip},
  number    = {1},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1473-0189},
  doi       = {10.1039/C5LC01195G},
  pages     = {70 -- 74},
  year      = {2016},
  abstract  = {Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing.},
  language  = {en}
}
@article{MuribYeapEurlingsetal.2016,
  author    = {Murib, M. S. and Yeap, W. S. and Eurlings, Y. and Grinsven, B. van and Boyen, H.-G. and Conings, B. and Michiels, L. and Ameloot, M. and Carleer, R. and Warmer, J. and Kaul, P. and Haenen, K. and Sch{\"o}ning, Michael Josef and Ceuninck, W. de and Wagner, P.},
  title     = {Heat-transfer based characterization of DNA on synthetic sapphire chips},
  series = {Sensors and Actuators B: Chemical},
  volume    = {230},
  journal   = {Sensors and Actuators B: Chemical},
  number    = {230},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.02.027},
  pages     = {260 -- 271},
  year      = {2016},
  abstract  = {In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material.},
  language  = {en}
}
@incollection{PoghossianSchusserBaeckeretal.2015,
  author    = {Poghossian, Arshak and Schusser, Sebastian and B{\"a}cker, M. and Leinhos, Marcel and Sch{\"o}ning, Michael Josef},
  title     = {Real-time in-situ electrical monitoring of the degradation of biopolymers using semiconductor field-effect devices},
  series = {Biodegradable biopolymers. Vol. 1},
  booktitle = {Biodegradable biopolymers. Vol. 1},
  publisher = {Nova Science Publ.},
  address   = {Hauppauge},
  isbn      = {978-1-63483-632-6},
  pages     = {135 -- 153},
  year      = {2015},
  language  = {en}
}
@article{OberlaenderKirchnerKeusgenetal.2015,
  author    = {Oberl{\"a}nder, Jan and Kirchner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Strategies in developing thin-film sensors for monitoring aseptic food processes : Theoretical considerations and investigations of passivation materials},
  series = {Electrochimica Acta},
  volume    = {183},
  journal   = {Electrochimica Acta},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0013-4686},
  doi       = {10.1016/j.electacta.2015.06.126},
  pages     = {130 -- 136},
  year      = {2015},
  abstract  = {The sterilization of packages in aseptic food processes is highly significant to maintain a consumer-safe product with extended shelf-life. Today, the sterilization of food packages is predominantly accomplished by gaseous hydrogen peroxide (H2O2) in combination with heat. In order to monitor this sterilization process, calorimetric gas sensors as differential set-up of two platinum temperature sensors representing a catalytically active (additionally deposition of MnO2) and a passive segment have been recently developed. The temperature rise of the exothermic decomposition serves as an indicator of the present H2O2 concentration. In the present work, a theoretical approach considering the sensor's thermochemistry and physical transport phenomena was formulated to evaluate the temperature rise based on the energy content of gaseous H2O2. In a further part of this work, three polymers have been analyzed with respect to their application as passivation materials. The examined polymers are photoresist SU-8, perfluoroalkoxy (PFA) and fluorinated ethylene propylene (FEP). Thermal analyses by means of differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) have been conducted to determine the operation limits of the polymers. The overall chemical resistance and stability of the polymers against the harsh environmental conditions during the sterilization process have been examined by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR).},
  language  = {en}
}
@article{MiyamatoSakakitaWagneretal.2015,
  author    = {Miyamato, Ko-ichiro and Sakakita, Sakura and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Application of chemical imaging sensor to in-situ pH imaging in the vicinity of a corroding metal surface},
  series = {Electrochimica Acta},
  volume    = {183},
  journal   = {Electrochimica Acta},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0013-4686},
  doi       = {10.1016/j.electacta.2015.07.184},
  pages     = {137 -- 142},
  year      = {2015},
  abstract  = {The chemical imaging sensor was applied to in-situ pH imaging of the solution in the vicinity of a corroding surface of stainless steel under potentiostatic polarization. A test piece of polished stainless steel was placed on the sensing surface leaving a narrow gap filled with artificial seawater and the stainless steel was corroded under polarization. The pH images obtained during polarization showed correspondence between the region of lower pH and the site of corrosion. It was also found that the pH value in the gap became as low as 2 by polarization, which triggered corrosion.},
  language  = {en}
}
@article{SchusserKrischerBaeckeretal.2015,
  author    = {Schusser, Sebastian and Krischer, Maximillian and B{\"a}cker, Matthias and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors},
  series = {Analytical Chemistry},
  volume    = {87},
  journal   = {Analytical Chemistry},
  number    = {13},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {1520-6882},
  doi       = {10.1021/acs.analchem.5b00617},
  pages     = {6607 -- 6613},
  year      = {2015},
  abstract  = {Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte-insulator-semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers.},
  language  = {en}
}
@inproceedings{OberlaenderJildehKirchneretal.2015,
  author    = {Oberl{\"a}nder, Jan and Jildeh, Zaid B. and Kirchner, Patrick and Wendeler, Luisa and Bromm, Alexander and Iken, Heiko and Wagner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Experimental and numerical evaluation of interdigitated electrode array for monitoring gaseous sterilization processes},
  series = {12. Dresdner Sensor-Symposium 2015},
  booktitle = {12. Dresdner Sensor-Symposium 2015},
  doi       = {10.5162/12dss2015/P3.11},
  pages     = {163 -- 168},
  year      = {2015},
  language  = {en}
}
@inproceedings{BreuerRaueMangetal.2015,
  author    = {Breuer, Lars and Raue, Markus and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, Ronald and Wagner, Torsten},
  title     = {Light-stimulated hydrogel actuators with incorporated graphene oxide for microfluidic applications},
  series = {12. Dresdner Sensor-Symposium 2015},
  booktitle = {12. Dresdner Sensor-Symposium 2015},
  doi       = {10.5162/12dss2015/P5.8},
  pages     = {206 -- 209},
  year      = {2015},
  language  = {en}
}
@incollection{DigelSadykovTemizArtmannetal.2015,
  author    = {Digel, Ilya and Sadykov, R. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations},
  series = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies},
  booktitle = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies},
  publisher = {Nova Science Publ.},
  isbn      = {9781634826990},
  pages     = {75 -- 99},
  year      = {2015},
  language  = {en}
}
@article{KowalskiLinderZierkeetal.2016,
  author    = {Kowalski, Julia and Linder, Peter and Zierke, S. and Wulfen, B. van and Clemens, J. and Konstantinidis, K. and Ameres, G. and Hoffmann, R. and Mikucki, J. and Tulaczyk, S. and Funke, O. and Blandfort, D. and Espe, Clemens and Feldmann, Marco and Francke, Gero and Hiecker, S. and Plescher, Engelbert and Sch{\"o}ngarth, Sarah and Dachwald, Bernd and Digel, Ilya and Artmann, Gerhard and Eliseev, D. and Heinen, D. and Scholz, F. and Wiebusch, C. and Macht, S. and Bestmann, U. and Reineking, T. and Zetzsche, C. and Schill, K. and F{\"o}rstner, R. and Niedermeier, H. and Szumski, A. and Eissfeller, B. and Naumann, U. and Helbing, K.},
  title     = {Navigation technology for exploration of glacier ice with maneuverable melting probes},
  series = {Cold Regions Science and Technology},
  journal   = {Cold Regions Science and Technology},
  number    = {123},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0165-232X},
  doi       = {10.1016/j.coldregions.2015.11.006},
  pages     = {53 -- 70},
  year      = {2016},
  abstract  = {The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.},
  language  = {en}
}
@article{DiktaKuehlheimMendoncaetal.2015,
  author    = {Dikta, Gerhard and K{\"u}hlheim, Ren{\´e} and Mendonca, Jorge and Una-Alcarez, Jacobo de},
  title     = {Asymptotic representation of presmoothed Kaplan-Meier integrals with covariates in a semiparametric censorship model},
  series = {Journal of Statistical Planning and Inference},
  volume    = {Vol. 171},
  journal   = {Journal of Statistical Planning and Inference},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0378-3758},
  doi       = {10.1016/j.jspi.2015.12.001},
  pages     = {10 -- 37},
  year      = {2015},
  language  = {en}
}
@article{DuongNguyenStaat2015,
  author    = {Duong, Minh Tuan and Nguyen, Nhu Huynh and Staat, Manfred},
  title     = {Physical response of hyperelastic models for composite materials and soft tissues},
  series = {Asia pacific journal on computational engineering},
  volume    = {2},
  journal   = {Asia pacific journal on computational engineering},
  number    = {3 (December 2015)},
  issn      = {2196-1166},
  doi       = {10.1186/s40540-015-0015-x},
  pages     = {1 -- 18},
  year      = {2015},
  language  = {en}
}
@article{OberlaenderJildehKirchneretal.2015,
  author    = {Oberl{\"a}nder, Jan and Jildeh, Zaid B. and Kirchner, Patrick and Wendeler, Luisa and Bromm, Alexander and Iken, Heiko and Wagner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Study of Interdigitated Electrode Arrays Using Experiments and Finite Element Models for the Evaluation of Sterilization Processes},
  series = {Sensors},
  volume    = {15},
  journal   = {Sensors},
  number    = {10},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s151026115},
  pages     = {26115 -- 26127},
  year      = {2015},
  abstract  = {In this work, a sensor to evaluate sterilization processes with hydrogen peroxide vapor has been characterized. Experimental, analytical and numerical methods were applied to evaluate and study the sensor behavior. The sensor set-up is based on planar interdigitated electrodes. The interdigitated electrode structure consists of 614 electrode fingers spanning over a total sensing area of 20 mm2. Sensor measurements were conducted with and without microbiological spores as well as after an industrial sterilization protocol. The measurements were verified using an analytical expression based on a first-order elliptical integral. A model based on the finite element method with periodic boundary conditions in two dimensions was developed and utilized to validate the experimental findings.},
  language  = {en}
}
@article{BronderPoghossianSchejaetal.2015,
  author    = {Bronder, Thomas and Poghossian, Arshak and Scheja, Sabrina and Wu, Chunsheng and Keusgen, Michael and Mewes, Dieter and Sch{\"o}ning, Michael Josef},
  title     = {DNA Immobilization and Hybridization Detection by the Intrinsic Molecular Charge Using Capacitive Field-Effect Sensors Modified with a Charged Weak Polyelectrolyte Layer},
  series = {Applied Materials \& Interfaces},
  volume    = {36},
  journal   = {Applied Materials \& Interfaces},
  number    = {7},
  publisher = {American Chemical Society},
  address   = {Washington, DC},
  doi       = {10.1021/acsami.5b05146},
  pages     = {20068 -- 20075},
  year      = {2015},
  abstract  = {Miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge favor the semiconductor field-effect platform as one of the most attractive approaches for the development of label-free DNA chips. In this work, a capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor covered with a layer-by-layer prepared, positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was used for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization. The negatively charged probe single-stranded DNA (ssDNA) molecules were electrostatically adsorbed onto the positively charged PAH layer, resulting in a preferentially flat orientation of the ssDNA molecules within the Debye length, thus yielding a reduced charge-screening effect and a higher sensor signal. Each sensor-surface modification step (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), reducing an unspecific adsorption by a blocking agent, incubation with noncomplementary DNA (ncDNA) solution) was monitored by means of capacitance-voltage and constant-capacitance measurements. In addition, the surface morphology of the PAH layer was studied by atomic force microscopy and contact-angle measurements. High hybridization signals of 34 and 43 mV were recorded in low-ionic strength solutions of 10 and 1 mM, respectively. In contrast, a small signal of 4 mV was recorded in the case of unspecific adsorption of fully mismatched ncDNA. The density of probe ssDNA and dsDNA molecules as well as the hybridization efficiency was estimated using the experimentally measured DNA immobilization and hybridization signals and a simplified double-layer capacitor model. The results of field-effect experiments were supported by fluorescence measurements, verifying the DNA-immobilization and hybridization event.},
  language  = {en}
}
@article{BronderPoghossianSchejaetal.2015,
  author    = {Bronder, Thomas and Poghossian, Arshak and Scheja, S. and Wu, Chunsheng and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Electrostatic Detection of Unlabelled Single- and Double-stranded DNA Using Capacitive Field-effect Devices Functionalized with a Positively Charged Polyelectrolyte Layer},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.710},
  pages     = {544 -- 547},
  year      = {2015},
  abstract  = {Capacitive field-effect electrolyte-insulator-semiconductor sensors consisting of an Al-p-Si-SiO2 structure have been used for the electrical detection of unlabelled single- and double-stranded DNA (dsDNA) molecules by their intrinsic charge. A simple functionalization protocol based on the layer-by-layer (LbL) technique was used to prepare a weak polyelectrolyte/probe-DNA bilayer, followed by the hybridization with complementary target DNA molecules. Due to the flat orientation of the LbL-adsorbed DNA molecules, a high sensor signal has been achieved. In addition, direct label-free detection of in-solution hybridized dsDNA molecules has been studied.},
  language  = {en}
}
@article{MiyamotoBingWagneretal.2015,
  author    = {Miyamoto, Ko-ichiro and Bing, Yu and Wagner, Torsten and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef},
  title     = {Visualization of Defects on a Cultured Cell Layer by Utilizing Chemical Imaging Sensor},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.806},
  pages     = {936 -- 939},
  year      = {2015},
  abstract  = {The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) inthe sample. In this study, a novel wound-healing assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the defect of a cell layer brought into proximity of the sensing surface.A reduced impedance inside the defect, which was artificially formed ina cell layer, was successfully visualized in a photocurrent image.},
  language  = {en}
}
@article{PilasMarianoKeusgenetal.2015,
  author    = {Pilas, Johanna and Mariano, K. and Keusgen, M. and Selmer, Thorsten and Sch{\"o}ning, Michael Josef},
  title     = {Optimization of an Enzyme-based Multi-parameter Biosensor for Monitoring Biogas Processes},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.702},
  pages     = {532 -- 535},
  year      = {2015},
  language  = {en}
}
@article{SchusserKrischerMolinetal.2015,
  author    = {Schusser, Sebastian and Krischer, M. and Molin, D. G. M. and Akker, N. M. S. van den and B{\"a}cker, Matthias and Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.815},
  pages     = {948 -- 951},
  year      = {2015},
  abstract  = {A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system.},
  language  = {en}
}
@article{MolinnusBaeckerSiegertetal.2015,
  author    = {Molinnus, Denise and B{\"a}cker, Matthias and Siegert, Petra and Willenberg, H. and Poghossian, Arshak and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Detection of Adrenaline Based on Substrate Recycling Amplification},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.708},
  pages     = {540 -- 543},
  year      = {2015},
  abstract  = {An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.},
  language  = {en}
}
@article{DantismTakenagaWagneretal.2015,
  author    = {Dantism, S. and Takenaga, S. and Wagner, P. and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Light-addressable Potentiometric Sensor (LAPS) Combined with Multi-chamber Structures to Investigate the Metabolic Activity of Cells},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.647},
  pages     = {384 -- 387},
  year      = {2015},
  abstract  = {LAPS are field-effect-based potentiometric sensors which are able to monitor analyte concentrations in a spatially resolved manner. Hence, a LAPS sensor system is a powerful device to record chemical imaging of the concentration of chemical species in an aqueous solution, chemical reactions, or the growth of cell colonies on the sensor surface, to record chemical images. In this work, multi-chamber 3D-printed structures made out of polymer (PP-ABS) were combined with LAPS chips to analyse differentially and simultaneously the metabolic activity of Escherichia coli K12 and Chinese hamster ovary (CHO) cells, and the responds of those cells to the addition of glucose solution.},
  language  = {en}
}
@inproceedings{PhamStaat2015,
  author    = {Pham, Phu Tinh and Staat, Manfred},
  title     = {A simplification for shakedown analysis of hardening structures},
  series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  publisher = {RWTH Aachen University},
  address   = {Aachen},
  organization    = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>},
  pages     = {1 -- 4},
  year      = {2015},
  language  = {en}
}
@inproceedings{DuongNguyenStaat2015,
  author    = {Duong, Minh Tuan and Nguyen, N. H. and Staat, Manfred},
  title     = {Modeling and simulation of a growing mass by the Smoothed Finite Element Method (SFEM)},
  series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  publisher = {RWTH Aachen University},
  address   = {Aachen},
  organization    = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>},
  pages     = {1 -- 4},
  year      = {2015},
  language  = {en}
}
@inproceedings{BhattaraiFrotscherStaat2015,
  author    = {Bhattarai, Aroj and Frotscher, Ralf and Staat, Manfred},
  title     = {Biomechanical study of the female pelvic floor dysfunction using the finite element method},
  series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  publisher = {RWTH Aachen University},
  address   = {Aachen},
  organization    = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>},
  pages     = {1 -- 4},
  year      = {2015},
  language  = {en}
}
@inproceedings{FrotscherStaat2015,
  author    = {Frotscher, Ralf and Staat, Manfred},
  title     = {An electromechanical model for cardiac tissue constructs},
  series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  publisher = {RWTH Aachen University},
  address   = {Aachen},
  organization    = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>},
  pages     = {1 -- 4},
  year      = {2015},
  language  = {en}
}
@article{DuongNguyenTranetal.2015,
  author    = {Duong, Minh Tuan and Nguyen, Nhu Huynh and Tran, Thanh Ngoc and Tolba, R. H. and Staat, Manfred},
  title     = {Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen},
  series = {International biomechanics},
  volume    = {Vol. 2},
  journal   = {International biomechanics},
  number    = {Iss. 1},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {2333-5432},
  doi       = {10.1080/23335432.2015.1049295},
  pages     = {79 -- 88},
  year      = {2015},
  language  = {en}
}
@article{DelleHuckBaeckeretal.2015,
  author    = {Delle, Lotta E. and Huck, Christina and B{\"a}cker, Matthias and M{\"u}ller, Frank and Grandthyll, Samuel and Jacobs, Karin and Lilischkis, Rainer and Vu, Xuan T. and Sch{\"o}ning, Michael Josef and Wagner, Patrick and Thoelen, Roland and Weil, Maryam and Ingebrandt, Sven},
  title     = {Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431863},
  pages     = {1327 -- 1334},
  year      = {2015},
  language  = {en}
}
@article{WarmerWagnerSchoeningetal.2015,
  author    = {Warmer, Johannes and Wagner, Patrick and Sch{\"o}ning, Michael Josef and Kaul, Peter},
  title     = {Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431882},
  pages     = {1289 -- 1298},
  year      = {2015},
  language  = {en}
}
@article{MolinnusBaeckerIkenetal.2015,
  author    = {Molinnus, Denise and B{\"a}cker, Matthias and Iken, Heiko and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Concept for a biomolecular logic chip with an integrated sensor and actuator function},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431913},
  pages     = {1382 -- 1388},
  year      = {2015},
  abstract  = {A concept for a new generation of an integrated multi-functional biosensor/actuator system is developed, which is based on biomolecular logic principles. Such a system is expected to be able to detect multiple biochemical input signals simultaneously and in real-time and convert them into electrical output signals with logical operations such as OR, AND, etc. The system can be designed as a closed-loop drug release device triggered by an enzyme logic gate, while the release of the drug induced by the actuator at the required dosage and timing will be controlled by an additional drug sensor. Thus, the system could help to make an accurate and specific diagnosis. The presented concept is exemplarily demonstrated by using an enzyme logic gate based on a glucose/glucose oxidase system, a temperature-responsive hydrogel mimicking the actuator function and an insulin (drug) sensor. In this work, the results of functional testing of individual amperometric glucose and insulin sensors as well as an impedimetric sensor for the detection of the hydrogel swelling/shrinking are presented.},
  language  = {en}
}
@article{SchoeningAbouzarIngebrandtetal.2006,
  author    = {Sch{\"o}ning, Michael Josef and Abouzar, Maryam H. and Ingebrandt, Sven and Platen, Johannes and Offenh{\"a}usser, Andreas and Poghossian, Arshak},
  title     = {Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices},
  series = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.},
  journal   = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.},
  number    = {paper 0915-R05-04},
  editor    = {Comini, Elisabetta},
  isbn      = {9781558998711},
  pages     = {89 -- 94},
  year      = {2006},
  language  = {en}
}
@inproceedings{PoghossianIngebrandtPlatenetal.2006,
  author    = {Poghossian, Arshak and Ingebrandt, S. and Platen, J. and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect sensors with charged macromolecules - from micro towards nano aspects},
  series = {Biochemical Sensing Utilisation of Micro-and Nanotechnologies, Warschau, Nov. 2005 : Lecture Notes of the ICB Seminar / ed.: M. Mascini, W. Torbicz},
  booktitle = {Biochemical Sensing Utilisation of Micro-and Nanotechnologies, Warschau, Nov. 2005 : Lecture Notes of the ICB Seminar / ed.: M. Mascini, W. Torbicz},
  publisher = {Polish Academy Sciences Press},
  address   = {Warsaw},
  pages     = {74 -- 81},
  year      = {2006},
  language  = {en}
}
@article{YoshinobuMoritzFingeretal.2006,
  author    = {Yoshinobu, Tatsuo and Moritz, Werner and Finger, Friedhelm and Sch{\"o}ning, Michael Josef},
  title     = {Application of thin-film amorphous silicon to chemical imaging},
  series = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.},
  journal   = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.},
  number    = {Paper 0910-A-20-01},
  editor    = {Comini, Elisabetta},
  isbn      = {9781558998711},
  pages     = {1 -- 10},
  year      = {2006},
  language  = {en}
}
@article{TakenagaSchneiderErbayetal.2015,
  author    = {Takenaga, Shoko and Schneider, Benno and Erbay, E. and Biselli, Manfred and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201532053},
  pages     = {1347 -- 1352},
  year      = {2015},
  abstract  = {A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.},
  language  = {en}
}
@article{FrotscherKochStaat2015,
  author    = {Frotscher, Ralf and Koch, Jan-Peter and Staat, Manfred},
  title     = {Computational investigation of drug action on human-induced stem cell derived cardiomyocytes},
  series = {Journal of biomechanical engineering},
  volume    = {Vol. 137},
  journal   = {Journal of biomechanical engineering},
  number    = {iss. 7},
  publisher = {ASME},
  address   = {New York},
  issn      = {1528-8951 (E-Journal); 0148-0731 (Print)},
  doi       = {10.1115/1.4030173},
  pages     = {071002-1 -- 071002-7},
  year      = {2015},
  language  = {en}
}
@article{KotliarKharoubiSchmidtTrucksaessetal.2009,
  author    = {Kotliar, Konstantin and Kharoubi, A. and Schmidt-Trucks{\"a}ß, A. and Halle, M. and Lanzl, I.},
  title     = {Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons?},
  series = {Acta Ophthalmologica},
  volume    = {Vol. 87},
  journal   = {Acta Ophthalmologica},
  number    = {Suppl. S244},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print)},
  pages     = {0},
  year      = {2009},
  language  = {en}
}
@article{MartinGonzalezKotliarRiosMartinezetal.2014,
  author    = {Martin-Gonzalez, Anabel and Kotliar, Konstantin and Rios-Martinez, Jorge and Lanzl, Ines and Navab, Nassir},
  title     = {Mediated-reality magnification for macular degeneration rehabilitation},
  series = {Journal of Modern Optics},
  volume    = {61},
  journal   = {Journal of Modern Optics},
  number    = {17},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1362-3044},
  doi       = {10.1080/09500340.2014.936110},
  pages     = {1400 -- 1408},
  year      = {2014},
  language  = {en}
}
@article{BreuerRaueKirschbaumetal.2015,
  author    = {Breuer, Lars and Raue, Markus and Kirschbaum, M. and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, R. and Wagner, Torsten},
  title     = {Light-controllable polymeric material based on temperature-sensitive hydrogels with incorporated graphene oxide},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431944},
  pages     = {1368 -- 1374},
  year      = {2015},
  abstract  = {Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel films with incorporated graphene oxide (GO) were developed and tested as light-stimulated actuators. GO dispersions were synthesized via Hummers method and characterized toward their optical properties and photothermal energy conversion. The hydrogels were prepared by means of photopolymerization. In addition, the influence of GO within the hydrogel network on the lower critical solution temperature (LCST) was investigated by differential scanning calorimetry (DSC). The optical absorbance and the response to illumination were determined as a function of GO concentration for thin hydrogel films. A proof of principle for the stimulation with light was performed.},
  language  = {en}
}
@article{PilasIkenSelmeretal.2015,
  author    = {Pilas, Johanna and Iken, Heiko and Selmer, Thorsten and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Development of a multi-parameter sensor chip for the simultaneous detection of organic compounds in biogas processes},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431894},
  pages     = {1306 -- 1312},
  year      = {2015},
  abstract  = {An enzyme-based multi-parameter biosensor is developed for monitoring the concentration of formate, d-lactate, and l-lactate in biological samples. The sensor is based on the specific dehydrogenation by an oxidized β-nicotinamide adenine dinucleotide (NAD+)-dependent dehydrogenase (formate dehydrogenase, d-lactic dehydrogenase, and l-lactic dehydrogenase, respectively) in combination with a diaphorase from Clostridium kluyveri (EC 1.8.1.4). The enzymes are immobilized on a platinum working electrode by cross-linking with glutaraldehyde (GA). The principle of the determination scheme in case of l-lactate is as follows: l-lactic dehydrogenase (l-LDH) converts l-lactate into pyruvate by reaction with NAD+. In the presence of hexacyanoferrate(III), the resulting reduced β-nicotinamide adenine dinucleotide (NADH) is then regenerated enzymatically by diaphorase. The electrochemical detection is based on the current generated by oxidation of hexacyanoferrate(II) at an applied potential of +0.3 V vs. an Ag/AgCl reference electrode. The biosensor will be electrochemically characterized in terms of linear working range and sensitivity. Additionally, the successful practical application of the sensor is demonstrated in an extract from maize silage.},
  language  = {en}
}
@article{JildehWagnerSchoeningetal.2015,
  author    = {Jildeh, Zaid B. and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Pieper, Martin},
  title     = {Simulating the electromagnetic-thermal treatment of thin aluminium layers for adhesion improvement},
  series = {Physica status solidi (a)},
  volume    = {Vol. 212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431893},
  pages     = {1234 -- 1241},
  year      = {2015},
  abstract  = {A composite layer material used in packaging industry is made from joining layers of different materials using an adhesive. An important processing step in the production of aluminium-containing composites is the surface treatment and consequent coating of adhesive material on the aluminium surface. To increase adhesion strength between aluminium layer and the adhesive material, the foil is heat treated. For efficient heating, induction heating was considered as state-of-the-art treatment process. Due to the complexity of the heating process and the unpredictable nature of the heating source, the control of the process is not yet optimised. In this work, a finite element analysis of the process was established and various process parameters were studied. The process was simplified and modelled in 3D. The numerical model contains an air domain, an aluminium layer and a copper coil fitted with a magnetic field concentrating material. The effect of changing the speed of the aluminium foil (or rolling speed) was studied with the change of the coil current. Statistical analysis was used for generating a general control equation of coil current with changing rolling speed.},
  language  = {en}
}