@inproceedings{ZaehlTheisWolfetal.2023,
  author    = {Z{\"a}hl, Philipp M. and Theis, Sabine and Wolf, Martin R. and K{\"o}hler, Klemens},
  title     = {Teamwork in software development and what personality has to do with it - an overview},
  series = {Virtual, Augmented and Mixed Reality},
  booktitle = {Virtual, Augmented and Mixed Reality},
  editor    = {Chen, Jessie Y. C. and Fragomeni, Gino},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-031-35633-9 (Print)},
  doi       = {10.1007/978-3-031-35634-6_10},
  pages     = {130 -- 153},
  year      = {2023},
  abstract  = {Due to the increasing complexity of software projects, software development is becoming more and more dependent on teams. The quality of this teamwork can vary depending on the team composition, as teams are always a combination of different skills and personality types. This paper aims to answer the question of how to describe a software development team and what influence the personality of the team members has on the team dynamics. For this purpose, a systematic literature review (n=48) and a literature search with the AI research assistant Elicit (n=20) were conducted. Result: A person's personality significantly shapes his or her thinking and actions, which in turn influences his or her behavior in software development teams. It has been shown that team performance and satisfaction can be strongly influenced by personality. The quality of communication and the likelihood of conflict can also be attributed to personality.},
  language  = {en}
}
@inproceedings{EichenbaumNikolovskiMuelhensetal.2023,
  author    = {Eichenbaum, Julian and Nikolovski, Gjorgji and M{\"u}lhens, Leon and Reke, Michael and Ferrein, Alexander and Scholl, Ingrid},
  title     = {Towards a lifelong mapping approach using Lanelet 2 for autonomous open-pit mine operations},
  series = {2023 IEEE 19th International Conference on Automation Science and Engineering (CASE)},
  booktitle = {2023 IEEE 19th International Conference on Automation Science and Engineering (CASE)},
  publisher = {IEEE},
  isbn      = {979-8-3503-2069-5 (Online)},
  doi       = {10.1109/CASE56687.2023.10260526},
  pages     = {8 Seiten},
  year      = {2023},
  abstract  = {Autonomous agents require rich environment models for fulfilling their missions. High-definition maps are a well-established map format which allows for representing semantic information besides the usual geometric information of the environment. These are, for instance, road shapes, road markings, traffic signs or barriers. The geometric resolution of HD maps can be as precise as of centimetre level. In this paper, we report on our approach of using HD maps as a map representation for autonomous load-haul-dump vehicles in open-pit mining operations. As the mine undergoes constant change, we also need to constantly update the map. Therefore, we follow a lifelong mapping approach for updating the HD maps based on camera-based object detection and GPS data. We show our mapping algorithm based on the Lanelet 2 map format and show our integration with the navigation stack of the Robot Operating System. We present experimental results on our lifelong mapping approach from a real open-pit mine.},
  language  = {en}
}
@inproceedings{ViehmannLimpertHofmannetal.2023,
  author    = {Viehmann, Tarik and Limpert, Nicolas and Hofmann, Till and Henning, Mike and Ferrein, Alexander and Lakemeyer, Gerhard},
  title     = {Winning the RoboCup logistics league with visual servoing and centralized goal reasoning},
  series = {RoboCup 2022: Robot World Cup XXV},
  booktitle = {RoboCup 2022: Robot World Cup XXV},
  editor    = {Eguchi, Amy and Lau, Nuno and Paetzel-Pr{\"u}smann, Maike and Wanichanon, Thanapat},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-031-28468-7 (Print)},
  doi       = {https://doi.org/10.1007/978-3-031-28469-4_25},
  pages     = {300 -- 312},
  year      = {2023},
  abstract  = {The RoboCup Logistics League (RCLL) is a robotics competition in a production logistics scenario in the context of a Smart Factory. In the competition, a team of three robots needs to assemble products to fulfill various orders that are requested online during the game. This year, the Carologistics team was able to win the competition with a new approach to multi-agent coordination as well as significant changes to the robot's perception unit and a pragmatic network setup using the cellular network instead of WiFi. In this paper, we describe the major components of our approach with a focus on the changes compared to the last physical competition in 2019.},
  language  = {en}
}
@inproceedings{NikolovskiLimpertNessauetal.2023,
  author    = {Nikolovski, Gjorgji and Limpert, Nicolas and Nessau, Hendrik and Reke, Michael and Ferrein, Alexander},
  title     = {Model-predictive control with parallelised optimisation for the navigation of autonomous mining vehicles},
  series = {2023 IEEE Intelligent Vehicles Symposium (IV)},
  booktitle = {2023 IEEE Intelligent Vehicles Symposium (IV)},
  publisher = {IEEE},
  isbn      = {979-8-3503-4691-6 (Online)},
  doi       = {10.1109/IV55152.2023.10186806},
  pages     = {6 Seiten},
  year      = {2023},
  abstract  = {The work in modern open-pit and underground mines requires the transportation of large amounts of resources between fixed points. The navigation to these fixed points is a repetitive task that can be automated. The challenge in automating the navigation of vehicles commonly used in mines is the systemic properties of such vehicles. Many mining vehicles, such as the one we have used in the research for this paper, use steering systems with an articulated joint bending the vehicle's drive axis to change its course and a hydraulic drive system to actuate axial drive components or the movements of tippers if available. To address the difficulties of controlling such a vehicle, we present a model-predictive approach for controlling the vehicle. While the control optimisation based on a parallel error minimisation of the predicted state has already been established in the past, we provide insight into the design and implementation of an MPC for an articulated mining vehicle and show the results of real-world experiments in an open-pit mine environment.},
  language  = {en}
}
@article{ŠakićMarinkovićButenwegetal.2023,
  author    = {Šakić, Bogdan and Marinković, Marko and Butenweg, Christoph and Klinkel, Sven},
  title     = {Influence of slab deflection on the out-of-plane capacity of unreinforced masonry partition walls},
  series = {Engineering Structures},
  volume    = {276},
  journal   = {Engineering Structures},
  editor    = {Yang, J.},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0141-0296},
  doi       = {10.1016/j.engstruct.2022.115342},
  year      = {2023},
  abstract  = {Severe damage of non-structural elements is noticed in previous earthquakes, causing high economic losses and posing a life threat for the people. Masonry partition walls are one of the most commonly used non-structural elements. Therefore, their behaviour under earthquake loading in out-of-plane (OOP) direction is investigated by several researches in the past years. However, none of the existing experimental campaigns or analytical approaches consider the influence of prior slab deflection on OOP response of partition walls. Moreover, none of the existing construction techniques for the connection of partition walls with surrounding reinforced concrete (RC) is investigated for the combined slab deflection and OOP loading. However, the inevitable time-dependent behaviour of RC slabs leads to high values of final slab deflections which can further influence boundary conditions of partition walls. Therefore, a comprehensive study on the influence of slab deflection on the OOP capacity of masonry partitions is conducted. In the first step, experimental tests are carried out. Results of experimental tests are further used for the calibration of the numerical model employed for a parametric study. Based on the results, behaviour under combined loading for different construction techniques is explained. The results show that slab deflection leads either to severe damage or to a high reduction of OOP capacity. Existing practical solutions do not account for these effects. In this contribution, recommendations to overcome the problems of combined slab deflection and OOP loading on masonry partition walls are given. Possible interaction of in-plane (IP) loading, with the combined slab deflection and OOP loading on partition walls, is not investigated in this study.},
  language  = {en}
}
@article{VoegeleJosyabhatlaBalletal.2023,
  author    = {V{\"o}gele, Stefan and Josyabhatla, Vishnu Teja and Ball, Christopher and Rhoden, Imke and Grajewski, Matthias and R{\"u}bbelke, Dirk and Kuckshinrichs, Wilhelm},
  title     = {Robust assessment of energy scenarios from stakeholders' perspectives},
  series = {Energy},
  journal   = {Energy},
  number    = {In Press, Article 128326},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-6785 (Online)},
  doi       = {10.1016/j.energy.2023.128326},
  year      = {2023},
  abstract  = {Using scenarios is vital in identifying and specifying measures for successfully transforming the energy system. Such transformations can be particularly challenging and require the support of a broader set of stakeholders. Otherwise, there will be opposition in the form of reluctance to adopt the necessary technologies. Usually, processes for considering stakeholders' perspectives are very time-consuming and costly. In particular, there are uncertainties about how to deal with modifications in the scenarios. In principle, new consulting processes will be required. In our study, we show how multi-criteria decision analysis can be used to analyze stakeholders' attitudes toward transition paths. Since stakeholders differ regarding their preferences and time horizons, we employ a multi-criteria decision analysis approach to identify which stakeholders will support or oppose a transition path. We provide a flexible template for analyzing stakeholder preferences toward transition paths. This flexibility comes from the fact that our multi-criteria decision aid-based approach does not involve intensive empirical work with stakeholders. Instead, it involves subjecting assumptions to robustness analysis, which can help identify options to influence stakeholders' attitudes toward transitions.},
  language  = {en}
}
@article{AyalaHarrisKleefeldetal.2023,
  author    = {Ayala, Rafael Ceja and Harris, Isaac and Kleefeld, Andreas and Pallikarakis, Nikolaos},
  title     = {Analysis of the transmission eigenvalue problem with two conductivity parameters},
  series = {Applicable Analysis},
  journal   = {Applicable Analysis},
  publisher = {Taylor \& Francis},
  issn      = {0003-6811},
  doi       = {10.1080/00036811.2023.2181167},
  pages     = {37 Seiten},
  year      = {2023},
  abstract  = {In this paper, we provide an analytical study of the transmission eigenvalue problem with two conductivity parameters. We will assume that the underlying physical model is given by the scattering of a plane wave for an isotropic scatterer. In previous studies, this eigenvalue problem was analyzed with one conductive boundary parameter whereas we will consider the case of two parameters. We prove the existence and discreteness of the transmission eigenvalues as well as study the dependence on the physical parameters. We are able to prove monotonicity of the first transmission eigenvalue with respect to the parameters and consider the limiting procedure as the second boundary parameter vanishes. Lastly, we provide extensive numerical experiments to validate the theoretical work.},
  language  = {en}
}
@inproceedings{AltherrConzenElsenetal.2023,
  author    = {Altherr, Lena and Conzen, Max and Elsen, Ingo and Frauenrath, Tobias and Lyrmann, Andreas},
  title     = {Sensor retrofitting of existing buildings in an interdisciplinary teaching project at university level},
  series = {Tagungsband AALE 2023 : mit Automatisierung gegen den Klimawandel},
  booktitle = {Tagungsband AALE 2023 : mit Automatisierung gegen den Klimawandel},
  editor    = {Reiff-Stephan, J{\"o}rg and J{\"a}kel, Jens and Schwarz, Andr{\´e}},
  publisher = {le-tex publishing services GmbH},
  address   = {Leipzig},
  isbn      = {978-3-910103-01-6},
  doi       = {10.33968/2023.04},
  pages     = {31 -- 40},
  year      = {2023},
  abstract  = {Existing residential buildings have an average lifetime of 100 years. Many of these buildings will exist for at least another 50 years. To increase the efficiency of these buildings while keeping costs at reasonable rates, they can be retrofitted with sensors that deliver information to central control units for heating, ventilation and electricity. This retrofitting process should happen with minimal intervention into existing infrastructure and requires new approaches for sensor design and data transmission. At FH Aachen University of Applied Sciences, students of different disciplines work together to learn how to design, build, deploy and operate such sensors. The presented teaching project already created a low power design for a combined CO2, temperature and humidity measurement device that can be easily integrated into most home automation systems},
  language  = {en}
}
@inproceedings{SchulteSchwagerNoureldinetal.2023,
  author    = {Schulte, Jonas and Schwager, Christian and Noureldin, Kareem and May, Martin and Teixeira Boura, Cristiano Jos{\´e} and Herrmann, Ulf},
  title     = {Gradient controlled startup procedure of a molten-salt power-to-heat energy storage plant based on dynamic process simulation},
  series = {SolarPACES: Solar Power \& Chemical Energy Systems},
  booktitle = {SolarPACES: Solar Power \& Chemical Energy Systems},
  number    = {2815 / 1},
  publisher = {AIP conference proceedings / American Institute of Physics},
  address   = {Melville, NY},
  isbn      = {978-0-7354-4623-6},
  issn      = {1551-7616 (online)},
  doi       = {10.1063/5.0148741},
  pages     = {9 Seiten},
  year      = {2023},
  abstract  = {The integration of high temperature thermal energy storages into existing conventional power plants can help to reduce the CO2 emissions of those plants and lead to lower capital expenditures for building energy storage systems, due to the use of synergy effects [1]. One possibility to implement that, is a molten salt storage system with a powerful power-to-heat unit. This paper presents two possible control concepts for the startup of the charging system of such a facility. The procedures are implemented in a detailed dynamic process model. The performance and safety regarding the film temperatures at heat transmitting surfaces are investigated in the process simulations. To improve the accuracy in predicting the film temperatures, CFD simulations of the electrical heater are carried out and the results are merged with the dynamic model. The results show that both investigated control concepts are safe regarding the temperature limits. The gradient controlled startup performed better than the temperature-controlled startup. Nevertheless, there are several uncertainties that need to be investigated further.},
  language  = {en}
}
@article{HammerQuitterMayntzetal.2023,
  author    = {Hammer, Thorben and Quitter, Julius and Mayntz, Joscha and Bauschat, J.-Michael and Dahmann, Peter and G{\"o}tten, Falk and Hille, Sebastian and Stumpf, Eike},
  title     = {Free fall drag estimation of small-scale multirotor unmanned aircraft systems using computational fluid dynamics and wind tunnel experiments},
  series = {CEAS Aeronautical Journal},
  journal   = {CEAS Aeronautical Journal},
  publisher = {Springer},
  address   = {Wien},
  issn      = {1869-5590 (Online)},
  doi       = {10.1007/s13272-023-00702-w},
  pages     = {14 Seiten},
  year      = {2023},
  abstract  = {New European Union (EU) regulations for UAS operations require an operational risk analysis, which includes an estimation of the potential danger of the UAS crashing. A key parameter for the potential ground risk is the kinetic impact energy of the UAS. The kinetic energy depends on the impact velocity of the UAS and, therefore, on the aerodynamic drag and the weight during free fall. Hence, estimating the impact energy of a UAS requires an accurate drag estimation of the UAS in that state. The paper at hand presents the aerodynamic drag estimation of small-scale multirotor UAS. Multirotor UAS of various sizes and configurations were analysed with a fully unsteady Reynolds-averaged Navier-Stokes approach. These simulations included different velocities and various fuselage pitch angles of the UAS. The results were compared against force measurements performed in a subsonic wind tunnel and provided good consistency. Furthermore, the influence of the UAS`s fuselage pitch angle as well as the influence of fixed and free spinning propellers on the aerodynamic drag was analysed. Free spinning propellers may increase the drag by up to 110\%, depending on the fuselage pitch angle. Increasing the fuselage pitch angle of the UAS lowers the drag by 40\% up to 85\%, depending on the UAS. The data presented in this paper allow for increased accuracy of ground risk assessments.},
  language  = {en}
}
@inproceedings{BungLangohrWaldenberger2023,
  author    = {Bung, Daniel Bernhard and Langohr, Phillip and Waldenberger, Lisa},
  title     = {Influence of cycle number in CFD studies of labyrinth weirs},
  series = {Proceedings of the 40th IAHR World Congress (Vienna, 2023)},
  booktitle = {Proceedings of the 40th IAHR World Congress (Vienna, 2023)},
  editor    = {Habersack, Helmut and Tritthart, Michael},
  publisher = {International Association for Hydro-Environment Engineering and Research (IAHR)},
  address   = {Madrid},
  isbn      = {978-90-833476-1-5},
  issn      = {L 2521-7119 (online)},
  doi       = {10.3850/978-90-833476-1-5_iahr40wc-p0531-cd},
  year      = {2023},
  abstract  = {The major advantage of labyrinth weirs over linear weirs is hydraulic efficiency. In hydraulic modeling efforts, this strength contrasts with limited pump capacity as well as limited computational power for CFD simulations. For the latter, reducing the number of investigated cycles can significantly reduce necessary computational time. In this study, a labyrinth weir with different cycle numbers was investigated. The simulations were conducted in FLOW-3D HYDRO as a Large Eddy Simulation. With a mean deviation of 1.75 \% between simulated discharge coefficients and literature design equations, a reasonable agreement was found. For downstream conditions, overall consistent results were observed as well. However, the orientation of labyrinth weirs with a single cycle should be chosen carefully under consideration of the individual research purpose.},
  language  = {en}
}
@article{JanusAchtsnichtDrinicetal.2023,
  author    = {Janus, Kevin Alexander and Achtsnicht, Stefan and Drinic, Aleksander and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Transient magnesium-based thin-film temperature sensor on a flexible, bioabsorbable substrate for future medical applications},
  series = {Applied Research},
  journal   = {Applied Research},
  number    = {Accepted manuscript},
  publisher = {Wiley-VCH},
  issn      = {2702-4288 (Print)},
  doi       = {10.1002/appl.202300102},
  pages     = {22 Seiten},
  year      = {2023},
  abstract  = {In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin-film magnesium-based meander-like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium-based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue-like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium-based layers. The 3-layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C.},
  language  = {en}
}
@article{JanusAchtsnichtTempeletal.2023,
  author    = {Janus, Kevin Alexander and Achtsnicht, Stefan and Tempel, Laura and Drinic, Aleksaner and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon},
  series = {Physica status solidi : pss. A, Applications and materials science},
  volume    = {220},
  journal   = {Physica status solidi : pss. A, Applications and materials science},
  number    = {22},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300 (Print)},
  doi       = {10.1002/pssa.202300081},
  pages     = {10 Seiten},
  year      = {2023},
  abstract  = {Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5-10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.},
  language  = {en}
}
@inproceedings{NethSchubaBrodkorbetal.2023,
  author    = {Neth, Jannik and Schuba, Marko and Brodkorb, Karsten and Neugebauer, Georg and H{\"o}ner, Tim and Hack, Sacha},
  title     = {Digital forensics triage app for android},
  series = {ARES '23: Proceedings of the 18th International Conference on Availability, Reliability and Security},
  booktitle = {ARES '23: Proceedings of the 18th International Conference on Availability, Reliability and Security},
  publisher = {ACM},
  isbn      = {9798400707728},
  doi       = {10.1145/3600160.3605017},
  pages     = {6 Seiten},
  year      = {2023},
  abstract  = {Digital forensics of smartphones is of utmost importance in many criminal cases. As modern smartphones store chats, photos, videos etc. that can be relevant for investigations and as they can have storage capacities of hundreds of gigabytes, they are a primary target for forensic investigators. However, it is exactly this large amount of data that is causing problems: extracting and examining the data from multiple phones seized in the context of a case is taking more and more time. This bears the risk of wasting a lot of time with irrelevant phones while there is not enough time left to analyze a phone which is worth examination. Forensic triage can help in this case: Such a triage is a preselection step based on a subset of data and is performed before fully extracting all the data from the smartphone. Triage can accelerate subsequent investigations and is especially useful in cases where time is essential. The aim of this paper is to determine which and how much data from an Android smartphone can be made directly accessible to the forensic investigator - without tedious investigations. For this purpose, an app has been developed that can be used with extremely limited storage of data in the handset and which outputs the extracted data immediately to the forensic workstation in a human- and machine-readable format.},
  language  = {en}
}
@article{BlockMayWetzeletal.2023,
  author    = {Block, Franziska and May, Alexander and Wetzel, Katharina and Adels, Klaudia and Elbers, Gereon and Schulze, Margit and Monakhova, Yulia},
  title     = {What is the best spectroscopic method for simultaneous analysis of organic acids and (poly)saccharides in biological matrices: Example of Aloe vera extracts?},
  series = {Talanta Open},
  volume    = {7},
  journal   = {Talanta Open},
  number    = {Art. No. 100220},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2666-8319},
  doi       = {10.1016/j.talo.2023.100220},
  pages     = {1 -- 9},
  year      = {2023},
  abstract  = {Several species of (poly)saccharides and organic acids can be found often simultaneously in various biological matrices, e.g., fruits, plant materials, and biological fluids. The analysis of such matrices sometimes represents a challenging task. Using Aloe vera (A. vera) plant materials as an example, the performance of several spectro-scopic methods (80 MHz benchtop NMR, NIR, ATR-FTIR and UV-vis) for the simultaneous analysis of quality parameters of this plant material was compared. The determined parameters include (poly)saccharides such as aloverose, fructose and glucose as well as organic acids (malic, lactic, citric, isocitric, acetic, fumaric, benzoic and sorbic acids). 500 MHz NMR and high-performance liquid chromatography (HPLC) were used as the reference methods. UV-vis data can be used only for identification of added preservatives (benzoic and sorbic acids) and drying agent (maltodextrin) and semiquantitative analysis of malic acid. NIR and MIR spectroscopies combined with multivariate regression can deliver more informative overview of A. vera extracts being able to additionally quantify glucose, aloverose, citric, isocitric, malic, lactic acids and fructose. Low-field NMR measurements can be used for the quantification of aloverose, glucose, malic, lactic, acetic, and benzoic acids. The benchtop NMR method was successfully validated in terms of robustness, stability, precision, reproducibility and limit of detection (LOD) and quantification (LOQ), respectively. All spectroscopic techniques are useful for the screening of (poly)saccharides and organic acids in plant extracts and should be applied according to its availability as well as information and confidence required for the specific analytical goal. Benchtop NMR spectroscopy seems to be the most feasible solution for quality control of A. vera products.},
  language  = {en}
}
@article{AdelsElbersDiehletal.2023,
  author    = {Adels, Klaudia and Elbers, Gereon and Diehl, Bernd and Monakhova, Yulia},
  title     = {Multicomponent analysis of dietary supplements containing glucosamine and chondroitin: comparative low- and high-field NMR spectroscopic study},
  series = {Analytical Sciences},
  volume    = {2023},
  journal   = {Analytical Sciences},
  publisher = {Springer Verlag},
  address   = {Cham},
  issn      = {1348-2246 (Online)},
  doi       = {10.1007/s44211-023-00433-2},
  pages     = {13 Seiten},
  year      = {2023},
  abstract  = {With the prevalence of glucosamine- and chondroitin-containing dietary supplements for people with osteoarthritis in the marketplace, it is important to have an accurate and reproducible analytical method for the quantitation of these compounds in finished products. NMR spectroscopic method based both on low- (80 MHz) and high- (500-600 MHz) field NMR instrumentation was established, compared and validated for the determination of chondroitin sulfate and glucosamine in dietary supplements. The proposed method was applied for analysis of 20 different dietary supplements. In the majority of cases, quantification results obtained on the low-field NMR spectrometer are similar to those obtained with high-field 500-600 MHz NMR devices. Validation results in terms of accuracy, precision, reproducibility, limit of detection and recovery demonstrated that the developed method is fit for purpose for the marketed products. The NMR method was extended to the analysis of methylsulfonylmethane, adulterant maltodextrin, acetate and inorganic ions. Low-field NMR can be a quicker and cheaper alternative to more expensive high-field NMR measurements for quality control of the investigated dietary supplements. High-field NMR instrumentation can be more favorable for samples with complex composition due to better resolution, simultaneously giving the possibility of analysis of inorganic species such as potassium and chloride.},
  language  = {en}
}
@article{TrappLammersEngudaretal.2023,
  author    = {Trapp, Svenja and Lammers, Tom and Engudar, Gokce and Hoehr, Cornelia and Denkova, Antonia G. and Paulßen, Elisabeth and de Kruijff, Robin M.},
  title     = {Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop},
  series = {EJNMMI Radiopharmacy and Chemistry},
  volume    = {2023},
  journal   = {EJNMMI Radiopharmacy and Chemistry},
  number    = {8, Article number: 9},
  publisher = {Springer Nature},
  issn      = {2365-421X},
  doi       = {10.1186/s41181-023-00195-2},
  pages     = {1 -- 14},
  year      = {2023},
  language  = {en}
}
@article{FalkenbergVossBottetal.2023,
  author    = {Falkenberg, Fabian and Voß, Leonie and Bott, Michael and Bongaerts, Johannes and Siegert, Petra},
  title     = {New robust subtilisins from halotolerant and halophilic Bacillaceae},
  series = {Applied Microbiology and Biotechnology},
  volume    = {107},
  journal   = {Applied Microbiology and Biotechnology},
  publisher = {Springer Nature},
  address   = {Berlin},
  issn      = {1432-0614},
  doi       = {10.1007/s00253-023-12553-w},
  pages     = {3939 -- 3954},
  year      = {2023},
  abstract  = {The aim of the present study was the characterisation of three true subtilisins and one phylogenetically intermediate subtilisin from halotolerant and halophilic microorganisms. Considering the currently growing enzyme market for efficient and novel biocatalysts, data mining is a promising source for novel, as yet uncharacterised enzymes, especially from halophilic or halotolerant Bacillaceae, which offer great potential to meet industrial needs. Both halophilic bacteria Pontibacillus marinus DSM 16465ᵀ and Alkalibacillus haloalkaliphilus DSM 5271ᵀ and both halotolerant bacteria Metabacillus indicus DSM 16189 and Litchfieldia alkalitelluris DSM 16976ᵀ served as a source for the four new subtilisins SPPM, SPAH, SPMI and SPLA. The protease genes were cloned and expressed in Bacillus subtilis DB104. Purification to apparent homogeneity was achieved by ethanol precipitation, desalting and ion-exchange chromatography. Enzyme activity could be observed between pH 5.0-12.0 with an optimum for SPPM, SPMI and SPLA around pH 9.0 and for SPAH at pH 10.0. The optimal temperature for SPMI and SPLA was 70 °C and for SPPM and SPAH 55 °C and 50 °C, respectively. All proteases showed high stability towards 5\% (w/v) SDS and were active even at NaCl concentrations of 5 M. The four proteases demonstrate potential for future biotechnological applications.},
  language  = {en}
}
@inproceedings{ChircuCzarneckiFriedmannetal.2023,
  author    = {Chircu, Alina and Czarnecki, Christian and Friedmann, Daniel and Pomaskow, Johanna and Sultanow, Eldar},
  title     = {Towards a Digital Twin of Society},
  series = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023},
  booktitle = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023},
  publisher = {University of Hawai'i},
  address   = {Honolulu},
  isbn      = {978-0-9981331-6-4},
  pages     = {6748 -- 6757},
  year      = {2023},
  abstract  = {This paper describes the potential for developing a digital twin of society- a dynamic model that can be used to observe, analyze, and predict the evolution of various societal aspects. Such a digital twin can help governmental agencies and policy makers in interpreting trends, understanding challenges, and making decisions regarding investments or policies necessary to support societal development and ensure future prosperity. The paper reviews related work regarding the digital twin paradigm and its applications. The paper presents a motivating case study- an analysis of opportunities and challenges faced by the German federal employment agency, Bundesagentur f¨ur Arbeit (BA), proposes solutions using digital twins, and describes initial proofs of concept for such solutions.},
  language  = {en}
}
@article{HaegerWirgesTanzmannetal.2023,
  author    = {Haeger, Gerrit and Wirges, Jessika and Tanzmann, Nicole and Oyen, Sven and Jolmes, Tristan and Jaeger, Karl-Erich and Sch{\"o}rken, Ulrich and Bongaerts, Johannes and Siegert, Petra},
  title     = {Chaperone assisted recombinant expression of a mycobacterial aminoacylase in Vibrio natriegens and Escherichia coli capable of N-lauroyl-L-amino acid synthesis},
  series = {Microbial Cell Factories},
  journal   = {Microbial Cell Factories},
  number    = {22},
  publisher = {Springer Nature},
  issn      = {1475-2859},
  doi       = {10.1186/s12934-023-02079-1},
  pages     = {Article number: 77 (2023)},
  year      = {2023},
  abstract  = {Background Aminoacylases are highly promising enzymes for the green synthesis of acyl-amino acids, potentially replacing the environmentally harmful Schotten-Baumann reaction. Long-chain acyl-amino acids can serve as strong surfactants and emulsifiers, with application in cosmetic industries. Heterologous expression of these enzymes, however, is often hampered, limiting their use in industrial processes. Results We identified a novel mycobacterial aminoacylase gene from Mycolicibacterium smegmatis MKD 8, cloned and expressed it in Escherichia coli and Vibrio natriegens using the T7 overexpression system. The recombinant enzyme was prone to aggregate as inclusion bodies, and while V. natriegens Vmax™ could produce soluble aminoacylase upon induction with isopropyl β-d-1-thiogalactopyranoside (IPTG), E. coli BL21 (DE3) needed autoinduction with lactose to produce soluble recombinant protein. We successfully conducted a chaperone co-expression study in both organisms to further enhance aminoacylase production and found that overexpression of chaperones GroEL/S enhanced aminoacylase activity in the cell-free extract 1.8-fold in V. natriegens and E. coli. Eventually, E. coli ArcticExpress™ (DE3), which co-expresses cold-adapted chaperonins Cpn60/10 from Oleispira antarctica, cultivated at 12 °C, rendered the most suitable expression system for this aminoacylase and exhibited twice the aminoacylase activity in the cell-free extract compared to E. coli BL21 (DE3) with GroEL/S co-expression at 20 °C. The purified aminoacylase was characterized based on hydrolytic activities, being most stable and active at pH 7.0, with a maximum activity at 70 °C, and stability at 40 °C and pH 7.0 for 5 days. The aminoacylase strongly prefers short-chain acyl-amino acids with smaller, hydrophobic amino acid residues. Several long-chain amino acids were fairly accepted in hydrolysis as well, especially N-lauroyl-L-methionine. To initially evaluate the relevance of this aminoacylase for the synthesis of N-acyl-amino acids, we demonstrated that lauroyl-methionine can be synthesized from lauric acid and methionine in an aqueous system. Conclusion Our results suggest that the recombinant enzyme is well suited for synthesis reactions and will thus be further investigated.},
  language  = {en}
}