@article{BogoyavlenskiyDigelBerezin1997,
  author    = {Bogoyavlenskiy, A. P. and Digel, Ilya and Berezin, V. E.},
  title     = {Assessment of dot-blot ELISA sensitivity on membrane sorbent using various peroxidase substrates},
  year      = {1997},
  abstract  = {The sensitivity of the peroxidase reaction in dot-blot ELISA significantly depends on the substrate. The highest sensitivity is observed using benzidine and diamine- phenol combinations as the substrates due to the reaction of the coupled oxidation (NADI)},
  subject      = {Enzyme-linked immunosorbent assay},
  language  = {en}
}
@article{ZhubanovaDigelNojimaetal.2007,
  author    = {Zhubanova, Azhar A. and Digel, Ilya and Nojima, H. and Artmann, Gerhard},
  title     = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology},
  year      = {2007},
  abstract  = {The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.},
  subject      = {Clusterion},
  language  = {en}
}
@article{ZhubanovaAknazarovMansurovetal.2010,
  author    = {Zhubanova, Azhar A. and Aknazarov, S. K. and Mansurov, Zulkhair and Digel, Ilya and Kozhalakova, A. A. and Akimbekov, Nuraly Shardarbekovich and O'Heras, Carlos and Tazhibayeva, S. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials},
  year      = {2010},
  abstract  = {Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.},
  subject      = {Kohlenstofffaser},
  language  = {en}
}
@article{SeifarthSchehlLinderetal.2011,
  author    = {Seifarth, Volker and Schehl, D. and Linder, Peter and Gossmann, Matthias and Digel, Ilya and Artmann, Gerhard and Porst, Dariusz and Preiß, C. and Kayser, Peter and Pack, O. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds},
  year      = {2011},
  abstract  = {The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 \%. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.},
  subject      = {Tissue Engineering},
  language  = {en}
}
@article{PreissLinderWendtetal.2011,
  author    = {Preiß, C. and Linder, Peter and Wendt, K. and Krystek, M. and Digel, Ilya and Gossmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Bassam, Rasha and Artmann, Gerhard},
  title     = {Engineering technology for plant physiology and plant stress research},
  year      = {2011},
  abstract  = {Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.},
  subject      = {Pflanzenphysiologie},
  language  = {en}
}
@article{BassamArtmannHescheleretal.2011,
  author    = {Bassam, Rasha and Artmann, Gerhard and Hescheler, J{\"u}rgen and Graef, T. and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Arinkin, Vladimir and Gossmann, Matthias and Digel, Ilya},
  title     = {Alterations in human hemoglobin structure related to red blood cell storage},
  year      = {2011},
  abstract  = {The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing.},
  subject      = {H{\"a}moglobin},
  language  = {en}
}
@article{GorissenStaatLaack2012,
  author    = {Gorissen, P. and Staat, Manfred and Laack, Walter van},
  title     = {Experimentelle Kraftmessungen als Beitrag zur Wirksamkeitsbeurteilung von Schienbeinschonern im Fußballsport},
  series = {OUP Zeitschrift f{\"u}r die orthop{\"a}dische und unfallchirurgische Praxis},
  volume    = {1},
  journal   = {OUP Zeitschrift f{\"u}r die orthop{\"a}dische und unfallchirurgische Praxis},
  number    = {1},
  publisher = {Deutscher {\"A}rzte-Verlag},
  address   = {K{\"o}ln},
  issn      = {2193-5785},
  doi       = {10.3238/oup.2012.0010-0015},
  pages     = {10 -- 15},
  year      = {2012},
  abstract  = {Diese Studie besch{\"a}ftigte sich mit der D{\"a}mpfungswirkung von Schienbeinschonern, wie sie beim Fußball zum Einsatz kommen. Sie wurde mit Hilfe eines Pendelhammers durchgef{\"u}hrt, der verschiedene Aufschlagkr{\"a}fte auf die Schoner erm{\"o}glichte. Dabei wurde deutlich, dass Schienbeinschoner die beste Wirkung bei Maximalkr{\"a}ften unterhalb von 5kN erreichen k{\"o}nnen, dass bei gr{\"o}ßerer Belastung allerdings Verbesserungsbedarf besteht. Hierf{\"u}r konnte, u.a. durch den Einsatz neuer Materialien, ein guter Ansatzpunkt im „ad{\"a}quaten Zusammenspiel von Schale und Polsterung" der Schoner gefunden werden. Die Untersuchung hat weiterhin gezeigt, dass zumindest teilweise eine deutliche Verbesserung der D{\"a}mpfungswirkung der Schienbeinschoner in den letzten Jahren erreicht werden konnte.},
  subject      = {Fußball},
  language  = {de}
}
@inproceedings{SchoeningAbdelghani2012,
  author    = {Sch{\"o}ning, Michael Josef and Abdelghani, Adnane},
  title     = {Nanoscale Science and Technology (NS\&T'12) : Proceedings Book Humboldt Kolleg <2012, Tunisia> ; Tunisia, 17-19 March, 2012 / ed. by Michael J. Sch{\"o}ning ; Adnane Abdelghani},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-3544},
  year      = {2012},
  abstract  = {Proceedings of the 2nd Humboldt Kolleg, Hammamet, Tunisia Organizer: Alexander von Humboldt Stiftung, Germany. pdf 184 p. Welcome Address Dear Participants, Welcome to the 2nd Humboldt Kolleg in "Nanoscale Science and Technology" (NS\&T'12) in Tunisia, sponsored by the "Alexander von Humboldt" foundation. The NS\&T'12 multidisciplinary scientific program includes seven "hot" topics dealing with "Nanoscale Science and Technology" covering basic and application-oriented research as well as industrial (market) aspects: - Molecular Biophyics, Spectroscopy Techniques, Imaging Microscopy - Nanomaterials Synthesis for Medicine and Bio-chemical Sensors - Nanostructures, Semiconductors, Photonics and Nanodevices - New Technologies in Market Industry - Environment, Electro-chemistry, Bio-polymers and Fuel Cells - Nanomaterials, Photovoltaic, Modelling, Quantum Physics - Microelectronics, Sensors Networks and Embedded Systems We are deeply indebted to all members of the Scientific Committee and General Chairs for joint Sessions and to all speakers and chairmen, who have dedicated invaluable time and efforts for the realization of this event. On behalf of the Organizing Committee, we are cordially inviting you to join the conference and hope that your stay will be fruitful, rewarding and enjoyable. Prof. Dr. Michael J. Sch{\"o}ning, Prof. Dr. Adnane Abdelghani},
  subject      = {Biosensor},
  language  = {en}
}
@article{LeversStaatLaack2011,
  author    = {Levers, A. and Staat, Manfred and Laack, Walter van},
  title     = {Analyse der Langzeitwirkung der MBST® KernspinResonanzTherapie bei Gonarthrose},
  year      = {2011},
  abstract  = {Originalausgabe: Orthop{\"a}dische Praxis Jg. 47. 2011 H. 11; S. 536-543. Mit freundlicher Genehmigung des Verlags Zusammenfassung: Auf der Basis von Patientenabfragen mittels Fragebogen zum Schmerzempfinden und zur Einschr{\"a}nkung bei Aktivit{\"a}ten des allt{\"a}glichen Lebens wird die Langzeitwirkung der MBST® KernspinResonanz-Therapie bei Gonarthrose untersucht. An der Studie nahmen 39 Patienten teil, bei denen die Therapie bis zu vier Jahre zur{\"u}ckliegt. Neben einer Gesamtbetrachtung wird der Erfolg auch in Abh{\"a}ngigkeit von Alter, Geschlecht und sportlicher Aktivit{\"a}t analysiert. Insgesamt weist die Studie auf eine anhaltende Verbesserung des Gesundheitszustands mit zum Teil deutlicher Schmerzlinderung auch noch nach vier Jahren hin, jedoch mit einer leichten Schmerzzunahme gegen Ende des Untersuchungszeitraums von vier Jahren. Eine tendenziell positivere Wirkung bei Frauen, {\"a}lteren Menschen oder auch sportlich nicht-aktiven Patienten l{\"a}sst auf eine m{\"o}gliche Beeinflussung des Erfolgs der Therapie durch ({\"U}ber-)Belastung im Alltag schließen. Ein zus{\"a}tzlich positiver Effekt der Therapie auf die Knochendichte ist ebenfalls denkbar, dies bleibt jedoch offen.},
  subject      = {Kniegelenkarthrose},
  language  = {de}
}
@inproceedings{TranNovacekTolbaetal.2011,
  author    = {Tran, Thanh Ngoc and Novacek, V. and Tolba, R. and Klinge, U. and Turquier, F. and Staat, Manfred},
  title     = {Experimental and Computational approach to study colorectal anastomosis. ISB2011, Proceedings of the XXIII Congress of the International Society of Biomechanics, Brussels, Belgium, July 3-7, 2011},
  year      = {2011},
  abstract  = {Summary: This paper presents a methodology to study and understand the mechanics of stapled anastomotic behaviors by combining empirical experimentation and finite element analysis. Performance of stapled anastomosis is studied in terms of leakage and numerical results which are compared to in vitro experiments performed on fresh porcine tissue. Results suggest that leaks occur between the tissue and staple legs penetrating through the tissue.},
  subject      = {Anastomose},
  language  = {en}
}
@article{StaatBallmann1988,
  author    = {Staat, Manfred and Ballmann, J.},
  title     = {Computation of impacts on elastic solids by methods of bicharacteristics},
  series = {Computational Mechanics '88 : theory and applications ; proceedings of the International Conference on Computational Engineering Science April 10-14, 1988, Atlanta, GA, USA ; vol. 2},
  journal   = {Computational Mechanics '88 : theory and applications ; proceedings of the International Conference on Computational Engineering Science April 10-14, 1988, Atlanta, GA, USA ; vol. 2},
  pages     = {1719 -- 1722},
  year      = {1988},
  abstract  = {Shock waves, explosions, impacts or cavitation bubble collapses may generate stress waves in solids causing cracks or unexpected dammage due to focussing, physical nonlinearity or interaction with existing cracks. There is a growing interest in wave propagation, which poses many novel problems to experimentalists and theorists.},
  subject      = {Bicharakteristikenverfahren},
  language  = {en}
}
@inproceedings{HeerRedkowitzKraft2008,
  author    = {Heer, Thomas and Redkowitz, Daniel and Kraft, Bodo},
  title     = {Tool Support for the Integration of Light-Weight Ontologies},
  isbn      = {978-3-642-00670-8},
  year      = {2008},
  abstract  = {Abstract of the authors: In many areas of computer science ontologies become more and more important. The use of ontologies for domain modeling often brings up the issue of ontology integration. The task of merging several ontologies, covering specific subdomains, into one united ontology has to be solved. Many approaches for ontology integration aim at automating the process of ontology alignment. However, a complete automation is not feasible, and user interaction is always required. Nevertheless, most ontology integration tools offer only very limited support for the interactive part of the integration process. In this paper, we present a novel approach for the interactive integration of ontologies. The result of the ontology integration is incrementally updated after each definition of a correspondence between ontology elements. The user is guided through the ontologies to be integrated. By restricting the possible user actions, the integrity of all defined correspondences is ensured by the tool we developed. We evaluated our tool by integrating different regulations concerning building design.},
  subject      = {Ontologie <Wissensverarbeitung>},
  language  = {de}
}
@article{KraftNagl2007,
  author    = {Kraft, Bodo and Nagl, Manfred},
  title     = {Visual Knowledge Specification for Conceptual Design: Definition and Tool Support},
  year      = {2007},
  abstract  = {In: Advanced Engineering Informatics. Vol 21, Issue 1, 2007, Pages 67-83 http://dx.doi.org/10.1016/j.aei.2006.10.001 eds. J.C. Kunz, I.F.C. Smith and T. Tomiyama, Elsevier, Seite 1-22 Current CAD tools are not able to support the conceptual design phase, and none of them provides a consistency analysis for sketches produced by architects. This phase is fundamental and crucial for the whole design and construction process of a building. To give architects a better support, we developed a CAD tool for conceptual design and a knowledge specification tool. The knowledge is specific to one class of buildings and it can be reused. Based on a dynamic and domain-specific knowledge ontology, different types of design rules formalize this knowledge in a graph-based form. An expressive visual language provides a user-friendly, human readable representation. Finally, a consistency analysis tool enables conceptual designs to be checked against this formal conceptual knowledge. In this article, we concentrate on the knowledge specification part. For that, we introduce the concepts and usage of a novel visual language and describe its semantics. To demonstrate the usability of our approach, two graph-based visual tools for knowledge specification and conceptual design are explained.},
  subject      = {CAD},
  language  = {en}
}
@inproceedings{KraftRetkowitz2006,
  author    = {Kraft, Bodo and Retkowitz, Daniel},
  title     = {Rule-Dependencies for Visual Knowledge Specification in Conceptual Design},
  year      = {2006},
  abstract  = {In: Proc. of the 11th Intl. Conf. on Computing in Civil and Building Engineering (ICCCBE-XI) ed. Hugues Rivard, Montreal, Canada, Seite 1-12, ACSE (CD-ROM), 2006 Currently, the conceptual design phase is not adequately supported by any CAD tool. Neither the support while elaborating conceptual sketches, nor the automatic proof of correctness with respect to effective restrictions is currently provided by any commercial tool. To enable domain experts to store the common as well as their personal domain knowledge, we develop a visual language for knowledge formalization. In this paper, a major extension to the already existing concepts is introduced. The possibility to define rule dependencies extends the expressiveness of the knowledge definition language and contributes to the usability of our approach.},
  subject      = {CAD},
  language  = {en}
}
@inproceedings{KraftRetkowitz2006,
  author    = {Kraft, Bodo and Retkowitz, Daniel},
  title     = {Graph Transformations for Dynamic Knowledge Processing},
  year      = {2006},
  abstract  = {In: Proceedings of the 39th Annual Hawaii International Conference on System Sciences, 2006. HICSS '06 http://dx.doi.org/10.1109/HICSS.2006.200 The conceptual design phase at the beginning of the building construction process is not adequately supported by any CAD-tool. Conceptual design support needs regarding two aspects: first, the architect must be able to develop conceptual sketches that provide abstraction from constructive details. Second, conceptually relevant knowledge should be available to check these conceptual sketches. The paper deals with knowledge to formalize for conceptual design. To enable domain experts formalizing knowledge, a graph-based specification is presented that allows the development of a domain ontology and design rules specific for one class of buildings at runtime. The provided tool support illustrates the introduced concepts and demonstrates the consistency analysis between knowledge and conceptual design.},
  subject      = {CAD},
  language  = {de}
}
@inproceedings{KraftRetkowitz2005,
  author    = {Kraft, Bodo and Retkowitz, Daniel},
  title     = {Operationale Semantikdefinition f{\"u}r konzeptuelles Regelwissen},
  year      = {2005},
  abstract  = {In: Forum Bauinformatik 2005 : junge Wissenschaftler forschen / [Lehrstuhl Bauinformatik, Brandenburgische Technische Universit{\"a}t Cottbus. Frank Schley ... (Hrsg.)]. - Cottbus : Techn. Universit{\"a}t 2005. S. 1-10 ISBN 3-934934-11-0 Mittels eines operationalen Ansatzes zur Semantikdefinition wird am Bei-spiel des konzeptuellen Geb{\"a}udeentwurfs ein Regelsystem formalisiert. Dazu werdenzwei Teile, zum einen das Regelwissen, zum anderen ein konzeptueller Entwurfsplan zun{\"a}chst informell eingef{\"u}hrt und dann formal beschrieben. Darauf aufbauend wird die Grundlage f{\"u}r eine Konsistenzpr{\"u}fung des konzeptuellen Entwurfs gegen das Regel-wissen formal angeben},
  subject      = {CAD},
  language  = {de}
}
@inproceedings{KraftWilhelms2005,
  author    = {Kraft, Bodo and Wilhelms, Nils},
  title     = {Visual Knowledge Specification for Conceptual Design},
  year      = {2005},
  abstract  = {Proc. of the 2005 ASCE Intl. Conf. on Computing in Civil Engineering (ICCC 2005) eds. L. Soibelman und F. Pena-Mora, Seite 1-14, ASCE (CD-ROM), Cancun, Mexico, 2005 Current CAD tools are not able to support the fundamental conceptual design phase, and none of them provides consistency analyses of sketches produced by architects. To give architects a greater support at the conceptual design phase, we develop a CAD tool for conceptual design and a knowledge specification tool allowing the definition of conceptually relevant knowledge. The knowledge is specific to one class of buildings and can be reused. Based on a dynamic knowledge model, different types of design rules formalize the knowledge in a graph-based realization. An expressive visual language provides a user-friendly, human readable representation. Finally, consistency analyses enable conceptual designs to be checked against this defined knowledge. In this paper we concentrate on the knowledge specification part of our project.},
  subject      = {CAD},
  language  = {en}
}
@inproceedings{KraftSchneider2005,
  author    = {Kraft, Bodo and Schneider, Gerd},
  title     = {Semantic Roomobjects for Conceptual Design Support : A Knowledge-based Approach},
  isbn      = {978-1-4020-3460-2},
  year      = {2005},
  abstract  = {In: Computer Aided Architectural Design Futures 2005 2005, Part 4, 207-216, DOI: http://dx.doi.org/10.1007/1-4020-3698-1_19 The conceptual design at the beginning of the building construction process is essential for the success of a building project. Even if some CAD tools allow elaborating conceptual sketches, they rather focus on the shape of the building elements and not on their functionality. We introduce semantic roomobjects and roomlinks, by way of example to the CAD tool ArchiCAD. These extensions provide a basis for specifying the organisation and functionality of a building and free architects being forced to directly produce detailed constructive sketches. Furthermore, we introduce consistency analyses of the conceptual sketch, based on an ontology containing conceptual relevant knowledge, specific to one class of buildings.},
  subject      = {CAD},
  language  = {en}
}
@techreport{NaglKraft2004,
  author    = {Nagl, Manfred and Kraft, Bodo},
  title     = {Graphbasierte Werkzeuge zur Unterst{\"u}tzung des konzeptuellen Geb{\"a}ude-Entwurfs : Bericht {\"u}ber den 2. F{\"o}rderzeitraum des Schwerpunktprogramms : DFG-Schwerpunktprogramm 1103 : Vernetzt-kooperative Planungsprozesse im Konstruktiven Ingenieurbau. - Auch unter dem Titel: Neue Software-Werkzeuge zur Unterst{\"u}tzung des konzeptuellen Geb{\"a}udeentwurfs},
  year      = {2004},
  abstract  = {Der konstruktive Entwurf wird in derzeitigen CAD-Systemen gut unterst{\"u}tzt, nicht aber der konzeptuelle Geb{\"a}ude-Entwurf. Dieser abstrahiert von konstruktiven Elementen wie Linie, Wand oder Decke, um auf die Konzepte, d.h. die eigentlichen Funktionen, heraus zu arbeiten. Diese abstraktere, funktionale Sichtweise auf ein Geb{\"a}ude ist w{\"a}hrend der fr{\"u}hen Entwurfsphase essentiell, um Struktur und Organisation des gesamten Geb{\"a}udes zu erfassen. Bereits in dieser Phase muss Fachwissen (z. B. rechtliche, {\"o}konomische und technische Bestimmungen) ber{\"u}cksichtigt werden. Im Rahmen des vorliegenden Projekts werden Software-Werkzeuge integriert in industrielle CAD-Systeme entwickelt, die den konzeptuellen Geb{\"a}ude-Entwurf erm{\"o}glichen und diesen gegen Fachwissen pr{\"u}fen. Das Projekt ist in zwei Teile gegliedert. Im Top-Down-Ansatz werden Datenstrukturen und Methoden zur Strukturierung, Repr{\"a}sentation und Evaluation von geb{\"a}udespezifischem Fachwissen erarbeitet. Dieser Teil baut auf den graphbasierten Werkzeugen PROGRES und UPGRADE des Lehrstuhls auf. Der Bottom-Up-Ansatz ist industriell orientiert und hat zum Ziel, das kommerzielle CAD-System ArchiCAD zu erweitern. Hierbei soll der fr{\"u}he, konzeptuelle Geb{\"a}ude-Entwurf in einem CAD-System erm{\"o}glicht werden. Der Entwurf kann dar{\"u}ber hinaus gegen das definierte Fachwissen gepr{\"u}ft werden. Im Rahmen des graphbasierten Top-Down-Ansatzes wurde zun{\"a}chst eine neue Spezifikationsmethode f{\"u}r die Sprache PROGRES entwickelt. Das PROGRES-System erlaubt die Spezifikation von Werkzeugen in deklarativer Form. {\"U}blicherweise wird dom{\"a}nenspezifisches Fachwissen in der PROGRES-Spezifikation codiert, das daraus generierte visuelle Werkzeug stellt dann die entsprechende Funktionalit{\"a}t zur Verf{\"u}gung. Mit dieser Methode sind am Lehrstuhl f{\"u}r Informatik III Werkzeuge f{\"u}r verschie-dene Anwendungsdom{\"a}nen entstanden. In unserem Fall versetzen wir einen Dom{\"a}nen-Experten, z. B. einen erfahrenen Architekten, in die Lage, Fachwissen zur Laufzeit einzugeben, dieses zu evaluieren, abzu{\"a}ndern oder zu erg{\"a}nzen. Im Rahmen der bisherigen Arbeit wurde dazu eine parametrisierte PROGRES-Spezifikation und zwei darauf aufbauende Werkzeuge entwickelt, welche die dynamische Eingabe von geb{\"a}ude-technisch relevantem Fachwissen erlauben und einen graphbasierten, konzeptuellen Geb{\"a}ude-Entwurf erm{\"o}glichen. In diesem konzeptuellen Geb{\"a}ude-Entwurf wird von Raumgr{\"o}ßen und Positionen abstrahiert, um die funktionale Struktur eines Geb{\"a}udes zu beschreiben. Das Fachwissen kann von einem Architekten visuell definiert werden. Es k{\"o}nnen semantische Einheiten, im einfachsten Fall R{\"a}ume, nach verschiedenen Kriterien kategorisiert und klassifiziert werden. Mit Hilfe von Attributen und Relationen k{\"o}nnen die semantischen Einheiten pr{\"a}ziser beschrieben und in Beziehung zueinander gesetzt werden. Die in PROGRES spezifizierten Konsistenz-Analysen erlauben die Pr{\"u}fung eines graphbasierten konzeptuellen Geb{\"a}ude-Entwurfs gegen das dynamisch eingef{\"u}gte Fachwissen. Im zweiten Teil des Forschungsprojekts, dem Bottom-Up-Ansatz, wird das CAD-System ArchiCAD erweitert, um den integrierten konzeptuellen Geb{\"a}ude-Entwurf zu erm{\"o}glichen. Der Architekt erh{\"a}lt dazu neue Entwurfselemente, die Raumobjekte, welche die relevanten semantischen Einheiten w{\"a}hrend der fr{\"u}hen Entwurfsphase repr{\"a}sentieren. Mit Hilfe der Raumobjekte kann der Architekt in ArchiCAD den Grundriss und das Raumprogramm eines Geb{\"a}udes entwerfen, ohne von konstruktiven Details in seiner Kreativit{\"a}t eingeschr{\"a}nkt zu werden. Die Arbeitsweise mit Raumobjekten entspricht dem informellen konzeptuellen Entwurf auf einer Papierskizze und ist daher f{\"u}r den Architekten intuitiv und einfach zu verwenden. Durch die Integration in ArchiCAD ergibt sich eine weitere Unterst{\"u}tzung: Das im Top-Down-Ansatz spezifizierte Fach-wissen wird verwendet, um den konzeptuellen Geb{\"a}ude-Entwurf des Architekten auf Regelverletzungen zu {\"u}berpr{\"u}fen. Entwurfsfehler werden angezeigt. Zum Abschluss des konzeptuellen Geb{\"a}ude-Entwurfs mit Raumobjekten wird durch ein weiteres neu entwickeltes Werkzeug eine initiale Wandstruktur automatisch erzeugt, die als Grundlage f{\"u}r die folgenden konstruktiven Entwurfsphasen dient. Alle beschriebenen Erwei-terungen sind in ArchiCAD integriert, sie sind f{\"u}r den Architekten daher leicht zu erlernen und einfach zu bedienen.},
  subject      = {CAD},
  language  = {de}
}
@inproceedings{KirchhofKraft2004,
  author    = {Kirchhof, M. and Kraft, Bodo},
  title     = {UML-based modeling of architectural knowledge and design},
  year      = {2004},
  abstract  = {IASSE-2004 - 13th International Conference on Intelligent and Adaptive Systems and Software Engineering eds. W. Dosch, N. Debnath, pp. 245-250, ISCA, Cary, NC, 1-3 July 2004, Nice, France We introduce a UML-based model for conceptual design support in civil engineering. Therefore, we identify required extensions to standard UML. Class diagrams are used for elaborating building typespecific knowledge: Object diagrams, implicitly contained in the architect's sketch, are validated against the defined knowledge. To enable the use of industrial, domain-specific tools, we provide an integrated conceptual design extension. The developed tool support is based on graph rewriting. With our approach architects are enabled to deal with semantic objects during early design phase, assisted by incremental consistency checks.},
  subject      = {UML},
  language  = {en}
}