@incollection{StangelMesekeHahnSteuerDankert2015, author = {Stangel-Meseke, Martina and Hahn, Pia and Steuer-Dankert, Linda}, title = {Ausblick: Der individualit{\"a}tsbezogene Diversity Management-Ansatz als Antwort auf Individualisierung}, series = {Diversity Management und Individualisierung}, booktitle = {Diversity Management und Individualisierung}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-658-07485-2}, pages = {23 -- 24}, year = {2015}, abstract = {Der Megatrend Individualisierung fordert von Unternehmen, ihre Strategien und Prozessabl{\"a}ufe bei zunehmender Globalisierung grundlegend zu {\"u}berdenken. W{\"a}hrend Strategien und Prozessabl{\"a}ufe im Unternehmen Standards unterliegen, entwickelt sich unsere Gesellschaft immer st{\"a}rker zu einem individuumszentrierten System, in dem es gilt, Werte und Lebensstile der Individuen zu ber{\"u}cksichtigen und derart wertzusch{\"a}tzen, dass Mitarbeitende motiviert und mit hoher Bindung an das Unternehmen die anstehenden Leistungen f{\"u}r das Unternehmen erbringen. Im Konzept DiM sind Standardisierung und Individualisierung keine gegens{\"a}tzlichen Aspekte, da bei DiM neben der Betrachtung des betriebswirtschaftlichen Nutzens dieses Konzepts f{\"u}r Unternehmen die Wertsch{\"a}tzung des Individuums als genuines Merkmal betont wird.}, language = {de} } @incollection{StangelMesekeHahnSteuerDankert2015, author = {Stangel-Meseke, Martina and Hahn, Pia and Steuer-Dankert, Linda}, title = {Der Individualisierungs-Trend pr{\"a}gt die Unternehmenszukunft}, series = {Diversity Management und Individualisierung}, booktitle = {Diversity Management und Individualisierung}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-658-07484-5}, doi = {10.1007/978-3-658-07485-2_1}, pages = {1 -- 3}, year = {2015}, abstract = {Laut Zukunftsinstitut (2010) stellt die Individualisierung eine langfristige und nachhaltige Ver{\"a}nderung dar, die die gesamte Gesellschaft (den einzelnen Menschen, Unternehmen, den Staat) betrifft und Auswirkungen auf nahezu alle Lebensbereiche (z. B. Arbeit, Wohnen, Partnerschaft) hat. Die Individualisierung beschreibt dabei die Entwicklung hin zur Fokussierung pers{\"o}nlicher Interessen und Lebensentscheidungen der einzelnen Person (Kunze, Individualisierung, 2011). Der Grund f{\"u}r diese Entwicklung sind laut Kunze (Individualisierung, 2011) Treiber wie steigendes Verm{\"o}gen, Bildung und Mobilit{\"a}t, was die einzelne Person unabh{\"a}ngiger von gr{\"o}ßeren Gemeinschaften macht und mehr Freiheit zur Selbstverwirklichung bietet. Als eine Konsequenz daraus werden Wertevorstellungen nicht mehr einfach hingenommen, sondern f{\"u}r die eigene Person {\"u}berpr{\"u}ft und individualisiert (Kunze, Individualisierung, 2011). So wies Beck bereits 1996 darauf hin, dass Individualisierung meint „erstens die Aufl{\"o}sung und zweitens die Abl{\"o}sung industriegesellschaftlicher Lebensformen durch andere, in denen die Einzelnen ihre Biographie selbst herstellen, inszenieren, zusammenflickschustern m{\"u}ssen" (Beck, Die Erfindung des Politischen, 1996, S. 150).}, language = {de} } @incollection{StangelMesekeHahnSteuerDankert2013, author = {Stangel-Meseke, Martina and Hahn, Pia and Steuer-Dankert, Linda}, title = {Balance durch Diversity Management : L{\"o}sungsans{\"a}tze f{\"u}r unternehmerische Herausforderungen aus Megatrends}, series = {Balance Management}, booktitle = {Balance Management}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-658-02191-7}, doi = {10.1007/978-3-658-02192-4_6}, pages = {145 -- 166}, year = {2013}, abstract = {Unsere unternehmerische Umwelt befindet sich in einem zunehmend dynamischen Wandel. Dies f{\"u}hrt dazu, dass Herausforderungen, denen sich Unternehmen stellen m{\"u}ssen, immer komplexer werden. Hier gilt es zunehmend, eine Balance zwischen verschiedenen Spannungsfeldern zu erreichen. Sogenannte Megatrends stellen die Treiber dieses Wandels dar. Als Megatrend werden nach dem Zukunftsinstitut (2010a) richtungsweisende Ver{\"a}nderungstendenzen aufgefasst, die alle Bereiche des Lebens sowohl individuell als auch gesellschaftlich beeinflussen und langfristige Auswirkungen haben.}, language = {de} } @incollection{Kurz2019, author = {Kurz, Melanie}, title = {Betrifft Design : von historischen Zukunftsperspektiven zu gegenw{\"a}rtigen Vergangenheitssehns{\"u}chten}, series = {Positionen des Neuen : Zukunft im Design}, booktitle = {Positionen des Neuen : Zukunft im Design}, publisher = {avedition}, address = {Stuttgart}, isbn = {978-3-89986-301-7}, pages = {136 -- 144}, year = {2019}, language = {de} } @incollection{Kurz2021, author = {Kurz, Melanie}, title = {Zur Multikausalit{\"a}t von Designentscheidungen - eine Beispielsammlung}, series = {Designentscheidungen: {\"u}ber Begr{\"u}ndungen im Entwurfsprozess}, booktitle = {Designentscheidungen: {\"u}ber Begr{\"u}ndungen im Entwurfsprozess}, publisher = {avedition}, address = {Stuttgart}, isbn = {978-3-89986-353-6}, pages = {22 -- 43}, year = {2021}, language = {de} } @incollection{Alt2022, author = {Alt, Helmut}, title = {Speicher speichern, Leiter leiten}, series = {Generationenprojekt Energiewende : Elektroenergiepolitik im Spannungsfeld zwischen Vision und Mission / Herbert Niederhausen (Hrsg.)}, booktitle = {Generationenprojekt Energiewende : Elektroenergiepolitik im Spannungsfeld zwischen Vision und Mission / Herbert Niederhausen (Hrsg.)}, publisher = {Books on Demand}, address = {Norderstedt}, isbn = {9783755774389}, pages = {125 -- 136}, year = {2022}, language = {de} } @incollection{Kurz2022, author = {Kurz, Melanie}, title = {Vom Werkbundstreit bis zur Papierformatnormung - welche Rolle der Chemie-Nobelpreistr{\"a}ger Friedrich Wilhelm Ostwald bei Typisierungsbestrebungen im Design spielt}, series = {Raster, Regeln, Ratio : Systematiken und Normungen des 20. Jahrhunderts}, volume = {2022}, booktitle = {Raster, Regeln, Ratio : Systematiken und Normungen des 20. Jahrhunderts}, publisher = {avedition}, address = {Stuttgart}, isbn = {978-3-89986-380-2}, pages = {6 -- 17}, year = {2022}, language = {de} } @incollection{Timme2022, author = {Timme, Michael}, title = {Wettbewerbsregeln (\S\S 24-27)}, series = {M{\"u}nchener Kommentar zum europ{\"a}ischen und deutschen Wettbewerbsrecht : Kartellrecht, Beihilfenrecht, Vergaberecht / hrsg von Franz J{\"u}rgen S{\"a}cker / Band 2: Deutsches Wettbewerbsrecht Gesetz gegen Wettbewerbsbeschr{\"a}nkungen (GWB), \S\S 1-96, 185, 186}, booktitle = {M{\"u}nchener Kommentar zum europ{\"a}ischen und deutschen Wettbewerbsrecht : Kartellrecht, Beihilfenrecht, Vergaberecht / hrsg von Franz J{\"u}rgen S{\"a}cker / Band 2: Deutsches Wettbewerbsrecht Gesetz gegen Wettbewerbsbeschr{\"a}nkungen (GWB), \S\S 1-96, 185, 186}, publisher = {Beck}, address = {M{\"u}nchen}, isbn = {978-3-406-75876-8}, pages = {589 -- 608}, year = {2022}, language = {de} } @incollection{EnglaenderKaminskiSchuba2022, author = {Engl{\"a}nder, Jacques and Kaminski, Lars and Schuba, Marko}, title = {Informationssicherheitsmanagement}, series = {Digitalisierungs- und Informationsmanagement}, booktitle = {Digitalisierungs- und Informationsmanagement}, publisher = {Springer Vieweg}, address = {Berlin}, isbn = {978-3-662-63757-9}, doi = {10.1007/978-3-662-63758-6_15}, pages = {373 -- 398}, year = {2022}, abstract = {Daten und Informationen sind die wichtigsten Ressourcen vieler Unternehmen und m{\"u}ssen daher entsprechend gesch{\"u}tzt werden. Getrieben durch die erh{\"o}hte Vernetzung von Informationstechnologie, die h{\"o}here Offenheit infolge datengetriebener Dienstleistungen und eine starke Zunahme an Datenquellen, r{\"u}cken die Gefahren von Informationsdiebstahl, -manipulation und -verlust in den Fokus von produzierenden Unternehmen. Auf dem Weg zum lern- und wandlungsf{\"a}higen Unternehmen kann dies zu einem großen Hindernis werden, da einerseits zu hohe Sicherheitsanforderungen neue Entwicklungen beschr{\"a}nken, andererseits wegen des Mangels an ausreichenden Informationssicherheitskonzepten Unternehmen weniger Innovationen wagen. Deshalb bedarf es individuell angepasster Konzepte f{\"u}r die Bereiche IT-Security, IT-Safety und Datenschutz f{\"u}r vernetzte Produkte, Produktion und Arbeitspl{\"a}tze. Bei der Entwicklung und Durchsetzung dieser Konzepte steht der Faktor Mensch im Zentrum aller {\"U}berlegungen. In diesem Kapitel wird dargestellt, wie der Faktor Mensch bei der Erstellung von Informationssicherheitskonzepten in verschiedenen Phasen zu beachten ist. Beginnend mit der Integration von Informationssystemen und damit verbundenen Sicherheitsmaßnahmen, {\"u}ber die Administration, bis hin zur Anwendung durch den Endnutzer, werden Methoden beschrieben, die den Menschen, verbunden mit seinem Mehrwert wie auch den Risiken, einschließen. Dabei werden sowohl Grundlagen aufgezeigt als auch Konzepte vorgestellt, mit denen Entscheider in der Unternehmens-IT Leitlinien f{\"u}r die Informationssicherheit festlegen k{\"o}nnen.}, language = {de} } @incollection{SchubaHoefken2022, author = {Schuba, Marko and H{\"o}fken, Hans-Wilhelm}, title = {Cybersicherheit in Produktion, Automotive und intelligenten Geb{\"a}uden}, series = {IT-Sicherheit - Technologien und Best Practices f{\"u}r die Umsetzung im Unternehmen}, booktitle = {IT-Sicherheit - Technologien und Best Practices f{\"u}r die Umsetzung im Unternehmen}, publisher = {Carl Hanser Verlag}, address = {M{\"u}nchen}, isbn = {978-3-446-47223-5}, doi = {10.3139/9783446473478.012}, pages = {193 -- 218}, year = {2022}, language = {de} } @incollection{BorggrafeOhndorfDachwaldetal.2012, author = {Borggrafe, Andreas and Ohndorf, Andreas and Dachwald, Bernd and Seboldt, Wolfgang}, title = {Analysis of interplanetary solar sail trajectories with attitude dynamics}, series = {Dynamics and Control of Space Systems 2012}, booktitle = {Dynamics and Control of Space Systems 2012}, publisher = {Univelt Inc}, address = {San Diego}, isbn = {978-0-87703-587-9}, pages = {1553 -- 1569}, year = {2012}, abstract = {We present a new approach to the problem of optimal control of solar sails for low-thrust trajectory optimization. The objective was to find the required control torque magnitudes in order to steer a solar sail in interplanetary space. A new steering strategy, controlling the solar sail with generic torques applied about the spacecraft body axes, is integrated into the existing low-thrust trajectory optimization software InTrance. This software combines artificial neural networks and evolutionary algorithms to find steering strategies close to the global optimum without an initial guess. Furthermore, we implement a three rotational degree-of-freedom rigid-body attitude dynamics model to represent the solar sail in space. Two interplanetary transfers to Mars and Neptune are chosen to represent typical future solar sail mission scenarios. The results found with the new steering strategy are compared to the existing reference trajectories without attitude dynamics. The resulting control torques required to accomplish the missions are investigated, as they pose the primary requirements to a real on-board attitude control system.}, language = {en} } @incollection{Fabo2017, author = {Fabo, Sabine}, title = {Das Dokumentarische als offene Konstruktion}, series = {Doris Frohnapfel, Documentary derivative}, booktitle = {Doris Frohnapfel, Documentary derivative}, publisher = {Totalverlag}, address = {K{\"o}ln}, isbn = {978-3-942040-03-7}, pages = {5 -- 23}, year = {2017}, language = {de} } @incollection{Fabo2017, author = {Fabo, Sabine}, title = {K{\"u}nstlerische Interventionen im {\"o}ffentlichen Raum}, series = {Die Experimentalstadt : Kreativit{\"a}t und die kulturelle Dimension der Nachhaltigen Entwicklung / Julia-Lena Reinermann, Friederike Behr (Hrsg.)}, booktitle = {Die Experimentalstadt : Kreativit{\"a}t und die kulturelle Dimension der Nachhaltigen Entwicklung / Julia-Lena Reinermann, Friederike Behr (Hrsg.)}, publisher = {Springer Fachmedien}, address = {Wiesbaden}, isbn = {978-3-658-14980-2 (Print)}, pages = {201 -- 217}, year = {2017}, abstract = {K{\"u}nstlerische Einlassungen auf den {\"o}ffentlichen Raum folgten lange Zeit dem Prinzip des subkulturellen Widerstands. Nur in dem strategischen, invasiven Akt der Intervention sah man noch die M{\"o}glichkeit einer weitgreifenden Kritik am kulturellen System. Begriffe wie Cultural Hacking, Guerilla Marketing, Adbusting, Konsumguerilla oder parasit{\"a}re Strategien pr{\"a}gten eine rebellische Auffassung der k{\"u}nstlerischen Einmischung. Gleichzeitig konnten diese Haltungen aufgrund ihres rebellischen Chics m{\"u}helos von dem, was sie kritisierten, aufgenommen und vereinnahmt werden. K{\"u}nstlerisches Handeln verharrt jedoch nicht in der Pose des Widerst{\"a}ndigen, sondern arbeitet kontinuierlich an der Problematisierung und Gestaltung der {\"o}ffentlichen Wahrnehmung. Viele Interventionen der Gegenwartskunst weisen unterschiedliche Grade der {\"A}sthetisierung, der Partizipation und der Kooperation in der Auseinandersetzung mit dem {\"o}ffentlichen Raum auf. Das wache Agieren im urbanen Kontext, die Irritation von Erwartungshaltungen, Fake und Desillusionierungsarbeit verstehen sich als k{\"u}nstlerische Arbeit an der Sensibilisierung der Wahrnehmung.}, language = {de} } @incollection{Fabo2018, author = {Fabo, Sabine}, title = {Einspr{\"u}che gegen den informierten Himmel ; Wegsehen; Distanzschaffen, Spielen}, series = {Orbitale Irritationen / Herausgeber: REMOTEWORDS: Achim Mohn{\´e} \& Uta Kopp}, booktitle = {Orbitale Irritationen / Herausgeber: REMOTEWORDS: Achim Mohn{\´e} \& Uta Kopp}, publisher = {Herbert von Halem Verlag}, address = {K{\"o}ln}, isbn = {978-3-86962-302-3}, pages = {20 -- 45}, year = {2018}, language = {de} } @incollection{Fabo2018, author = {Fabo, Sabine}, title = {Eine dekonstruktive Erinnerungsarbeit}, series = {Doris Frohnapfel, bewaffnete G{\"o}tter = Doris Frohnapfel, armed gods}, booktitle = {Doris Frohnapfel, bewaffnete G{\"o}tter = Doris Frohnapfel, armed gods}, publisher = {RpB Richter-Br{\"u}ckner}, address = {K{\"o}ln}, isbn = {978-3-9817241-2-7}, pages = {31 -- 35}, year = {2018}, language = {de} } @incollection{Fabo2022, author = {Fabo, Sabine}, title = {Pandemische Momente}, series = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)}, booktitle = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)}, publisher = {Campus}, address = {Frankfurt ; New York}, isbn = {978-3-593-51520-5 (Print)}, pages = {137 -- 140}, year = {2022}, language = {de} } @incollection{Fabo2022, author = {Fabo, Sabine}, title = {Pl{\"u}schviren - Zur Konstruktion von N{\"a}he in Zeiten der Pandemie}, series = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)}, booktitle = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)}, publisher = {Campus}, address = {Frankfurt ; New York}, isbn = {978-3-593-51520-5 (Print)}, pages = {45 -- 69}, year = {2022}, language = {de} } @incollection{DiekmannEggert2021, author = {Diekmann, Julian and Eggert, Mathias}, title = {Is a Progressive Web App an Alternative for Native App Development?}, series = {3. Wissenschaftsforum: Digitale Transformation (WiFo21) (Lecture Notes in Informatics ; P-319)}, booktitle = {3. Wissenschaftsforum: Digitale Transformation (WiFo21) (Lecture Notes in Informatics ; P-319)}, publisher = {Gesellschaft f{\"u}r Informatik}, address = {Darmstadt}, isbn = {978-3-88579-713-5}, pages = {35 -- 48}, year = {2021}, abstract = {The existence of several mobile operating systems, such as Android and iOS, is a challenge for developers because the individual platforms are not compatible with each other and require separate app developments. For this reason, cross-platform approaches have become popular but lack in cloning the native behavior of the different operating systems. Out of the plenty cross-platform approaches, the progressive web app (PWA) approach is perceived as promising but needs further investigation. Therefore, the paper at hand aims at investigating whether PWAs are a suitable alternative for native apps by developing a PWA clone of an existing app. Two surveys are conducted in which potential users test and evaluate the PWA prototype with regard to its usability. The survey results indicate that PWAs have great potential, but cannot be treated as a general alternative to native apps. For guiding developers when and how to use PWAs, four design guidelines for the development of PWA-based apps are derived based on the results.}, language = {en} } @incollection{AkimbekovDigelSherelkhanetal.2022, author = {Akimbekov, Nuraly S. and Digel, Ilya and Sherelkhan, Dinara K. and Razzaque, Mohammed S.}, title = {Vitamin D and Phosphate Interactions in Health and Disease}, series = {Phosphate Metabolism}, booktitle = {Phosphate Metabolism}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-91621-3}, doi = {10.1007/978-3-030-91623-7_5}, pages = {37 -- 46}, year = {2022}, abstract = {Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30-40\% and phosphate to nearly 80\%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease.}, language = {en} } @incollection{Dachwald2010, author = {Dachwald, Bernd}, title = {Solar sail dynamics and control}, series = {Encyclopedia of Aerospace Engineering}, booktitle = {Encyclopedia of Aerospace Engineering}, publisher = {Wiley}, address = {Hoboken}, doi = {10.1002/9780470686652.eae292}, year = {2010}, abstract = {Solar sails are large and lightweight reflective structures that are propelled by solar radiation pressure. This chapter covers their orbital and attitude dynamics and control. First, the advantages and limitations of solar sails are discussed and their history and development status is outlined. Because the dynamics of solar sails is governed by the (thermo-)optical properties of the sail film, the basic solar radiation pressure force models have to be described and compared before parameters to measure solar sail performance can be defined. The next part covers the orbital dynamics of solar sails for heliocentric motion, planetocentric motion, and motion at Lagrangian equilibrium points. Afterwards, some advanced solar radiation pressure force models are described, which allow to quantify the thrust force on solar sails of arbitrary shape, the effects of temperature, of light incidence angle, of surface roughness, and the effects of optical degradation of the sail film in the space environment. The orbital motion of a solar sail is strongly coupled to its rotational motion, so that the attitude control of these soft and flexible structures is very challenging, especially for planetocentric orbits that require fast attitude maneuvers. Finally, some potential attitude control methods are sketched and selection criteria are given.}, language = {en} } @incollection{Golland2019, author = {Golland, Alexander}, title = {Kommentierung von Artikel 94 bis 99 Datenschutz-Grundverordnung}, series = {DSGVO-BDSG}, booktitle = {DSGVO-BDSG}, editor = {Taeger, J{\"u}rgen and Gabel, Detlev}, edition = {3., v{\"o}llig neue bearbeitete und wesentlich erweiterte Auflage}, publisher = {Fachmedien Recht und Wirtschaft}, address = {Frankfurt am Main}, isbn = {978-3-8005-1659-9}, year = {2019}, abstract = {Das Werk kommentiert leicht verst{\"a}ndlich, aktuell und praxisnah die DSGVO wie auch das neue BDSG. Datenverarbeiter erhalten damit eine umfassende Darstellung mit Handlungsempfehlungen zum gesamten neuen Datenschutzrecht.}, language = {de} } @incollection{HoffschmidtAlexopoulosGoettscheetal.2022, author = {Hoffschmidt, Bernhard and Alexopoulos, Spiros and G{\"o}ttsche, Joachim and Sauerborn, Markus and Kaufhold, O.}, title = {High Concentration Solar Collectors}, series = {Comprehensive Renewable Energy (Second Edition) / Volume 3: Solar Thermal Systems: Components and Applications}, booktitle = {Comprehensive Renewable Energy (Second Edition) / Volume 3: Solar Thermal Systems: Components and Applications}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-12-819734-9}, doi = {10.1016/B978-0-12-819727-1.00058-3}, pages = {198 -- 245}, year = {2022}, abstract = {Solar thermal concentrated power is an emerging technology that provides clean electricity for the growing energy market. To the solar thermal concentrated power plant systems belong the parabolic trough, the Fresnel collector, the solar dish, and the central receiver system. For high-concentration solar collector systems, optical and thermal analysis is essential. There exist a number of measurement techniques and systems for the optical and thermal characterization of the efficiency of solar thermal concentrated systems. For each system, structure, components, and specific characteristics types are described. The chapter presents additionally an outline for the calculation of system performance and operation and maintenance topics. One main focus is set to the models of components and their construction details as well as different types on the market. In the later part of this article, different criteria for the choice of technology are analyzed in detail.}, language = {en} } @incollection{HoffschmidtAlexopoulosRauetal.2022, author = {Hoffschmidt, Bernhard and Alexopoulos, Spiros and Rau, Christoph and Sattler, Johannes, Christoph and Anthrakidis, Anette and Teixeira Boura, Cristiano Jos{\´e} and O'Connor, B. and Chico Caminos, R.A. and Rend{\´o}n, C. and Hilger, P.}, title = {Concentrating solar power}, series = {Comprehensive Renewable Energy (Second Edition) / Volume 3: Solar Thermal Systems: Components and Applications}, booktitle = {Comprehensive Renewable Energy (Second Edition) / Volume 3: Solar Thermal Systems: Components and Applications}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-12-819734-9}, pages = {670 -- 724}, year = {2022}, abstract = {The focus of this chapter is the production of power and the use of the heat produced from concentrated solar thermal power (CSP) systems. The chapter starts with the general theoretical principles of concentrating systems including the description of the concentration ratio, the energy and mass balance. The power conversion systems is the main part where solar-only operation and the increase in operational hours. Solar-only operation include the use of steam turbines, gas turbines, organic Rankine cycles and solar dishes. The operational hours can be increased with hybridization and with storage. Another important topic is the cogeneration where solar cooling, desalination and of heat usage is described. Many examples of commercial CSP power plants as well as research facilities from the past as well as current installed and in operation are described in detail. The chapter closes with economic and environmental aspects and with the future potential of the development of CSP around the world.}, language = {en} } @incollection{GollandBaumHammingeretal.2018, author = {Golland, Alexander and Baum, Michael and Hamminger, Alexander and Olbertz, Klaus}, title = {Ein {\"U}berblick: Umsetzung der Datenschutz-Grundverordnung}, series = {Das neue Datenschutzrecht in der Praxis des Steuerberaters Beitragssammlung}, booktitle = {Das neue Datenschutzrecht in der Praxis des Steuerberaters Beitragssammlung}, publisher = {NWB Verlag}, address = {Herne}, isbn = {978-3-482-67271-2}, pages = {8 -- 14}, year = {2018}, abstract = {Datenschutz und der 25.5.2018, wie ein Damoklesschwert scheinen beide Begriffe zurzeit im Raum zu stehe. Jeder weiß oder sollte zumindest um das Inkrafttreten der europ{\"a}ischen DSGVO am 25.5.2018 wissen. Viel wurde {\"u}ber wesentliche Neuerungen im Datenschutzrecht berichtet. Nicht zuletzt {\"u}ber gesteigerte organisatorische Anforderungen, Dokumentationspflichten und drohende Bußgelder. Doch was bedeuten diese Neuerungen ganz konkret f{\"u}r die Praxis des Steuerberaters? Anders als man vermuten k{\"o}nnte, werden die datenschutzrechtlichen Neuerungen nicht nur im Bereich der Kanzleiorganisation relevant. Auch im Steuerverwaltungsverfahren sieht sich der Steuerberater datenschutzrechtlichen Fragestellungen gegen{\"u}ber, bspw. dann, wenn die Finanzbeh{\"o}rden bei der Verarbeitung der personenbezogenen Daten des Mandanten gegen die DSGVO verstoßen. Gleiches gilt in Bereichen des Besch{\"a}ftigtendatenschutzes. Sowohl der Kanzleiinhaber selbst, als auch seine Arbeitgeber-Mandanten haben die Vorschriften des Besch{\"a}ftigtendatenschutzes einzuhalten. Der Steuerberater ben{\"o}tigt datenschutzrechtliches Know How, welches unmittelbar seine t{\"a}gliche Praxis betrifft. Andernfalls besteht das Risiko, dass dieser mit mehr Fragen, als Antworten zur{\"u}ck bleibt.}, language = {de} } @incollection{GollandSchneidereit2018, author = {Golland, Alexander and Schneidereit, Peter}, title = {Rechtliche Rahmenbedingungen des Identit{\"a}tsmangements im Cloud Computing}, series = {Identit{\"a}tsmanagement Im Cloud Computing : Evaluation {\"o}konomischer und Rechtlicher Rahmenbedingungen}, booktitle = {Identit{\"a}tsmanagement Im Cloud Computing : Evaluation {\"o}konomischer und Rechtlicher Rahmenbedingungen}, editor = {Borges, Georg and Werners, Brigitte}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-55584-2}, doi = {10.1007/978-3-662-55584-2_4}, pages = {53 -- 104}, year = {2018}, abstract = {Cloud Computing wirft in zahlreichen Rechtsbereichen neuartige juristische Fragestellungen auf. Ziel der Darstellung der rechtlichen Rahmenbedingungen ist, die das Identit{\"a}tsmanagement in der Cloud betreffenden Rechtsgrundlagen aus den unterschiedlichen Rechtsgebieten vorzustellen und einzuordnen, bevor im Rahmen des sechsten Kapitels die Darstellung der hieraus resultierenden Verpflichtungen in ihrer konkreten Form erfolgt.}, language = {de} } @incollection{Golland2022, author = {Golland, Alexander}, title = {Kommentierung von Artikel 94 bis 99 Datenschutz-Grundverordnung}, series = {DSGVO - BDSG - TTDSG: Datenschutzgrundverordnung - Bundesdatenschutzgesetz - Telekommunikation-Telemedien-Datenschutzgesetz}, booktitle = {DSGVO - BDSG - TTDSG: Datenschutzgrundverordnung - Bundesdatenschutzgesetz - Telekommunikation-Telemedien-Datenschutzgesetz}, editor = {Taeger, J{\"u}rgen and Gabel, Detlev}, edition = {4., neu bearbeitete Auflage. 2022}, publisher = {Fachmedien Recht und Wirtschaft}, address = {Frankfurt am Main}, isbn = {978-3-8005-1760-2}, pages = {1575 -- 1621}, year = {2022}, abstract = {Das Werk kommentiert leicht verst{\"a}ndlich, aktuell und praxisnah die DSGVO sowie das BDSG und - neu - auch das TTDSG (Telekommunikation-Telemedien-Datenschutzgesetz). Verantwortliche erhalten damit eine umfassende Darstellung mit Handlungsempfehlungen zum gesamten neuen Datenschutzrecht. Betriebliche Datenschutzbeauftragte k{\"o}nnen sich an den fundierten Kommentierungen orientieren, in denen Literatur und Rechtsprechung aktuell ber{\"u}cksichtigt wurden.}, language = {de} } @incollection{LeiseAltherr2021, author = {Leise, Philipp and Altherr, Lena}, title = {Experimental evaluation of resilience metrics in a fluid system}, series = {Mastering Uncertainty in Mechanical Engineering}, booktitle = {Mastering Uncertainty in Mechanical Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-78356-3}, pages = {442 -- 447}, year = {2021}, language = {en} } @incollection{AltherrLeisePfetschetal.2021, author = {Altherr, Lena and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas}, title = {Optimal design of resilient technical systems on the example of water supply systems}, series = {Mastering Uncertainty in Mechanical Engineering}, booktitle = {Mastering Uncertainty in Mechanical Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-78356-3}, pages = {429 -- 433}, year = {2021}, language = {en} } @incollection{AltherrLeise2021, author = {Altherr, Lena and Leise, Philipp}, title = {Resilience as a concept for mastering uncertainty}, series = {Mastering Uncertainty in Mechanical Engineering}, booktitle = {Mastering Uncertainty in Mechanical Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-78353-2}, doi = {10.1007/978-3-030-78354-9}, pages = {412 -- 417}, year = {2021}, language = {en} } @incollection{Golland2020, author = {Golland, Alexander}, title = {Struggling with users' consent: Economic approach to solve the issue of coupling}, series = {Turning Point in Data Protection Law}, booktitle = {Turning Point in Data Protection Law}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-8487-6909-4}, doi = {10.5771/9783748921561-121}, pages = {121 -- 126}, year = {2020}, language = {en} } @incollection{GollandOhrtmann2020, author = {Golland, Alexander and Ohrtmann, Jan-Peter}, title = {Video surveillance: The supervisory authorities' view andrecent case law}, series = {Turning Point in Data Protection Law}, booktitle = {Turning Point in Data Protection Law}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-8487-6909-4}, doi = {10.5771/9783748921561-175}, pages = {175 -- 178}, year = {2020}, language = {en} } @incollection{AltherrDoerigEdereretal.2017, author = {Altherr, Lena and D{\"o}rig, Bastian and Ederer, Thorsten and Pelz, Peter Franz and Pfetsch, Marc and Wolf, Jan}, title = {A mixed-integer nonlinear program for the design of gearboxes}, series = {Operations Research Proceedings 2016}, booktitle = {Operations Research Proceedings 2016}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-55701-4}, doi = {10.1007/978-3-319-55702-1_31}, pages = {227 -- 233}, year = {2017}, abstract = {Gearboxes are mechanical transmission systems that provide speed and torque conversions from a rotating power source. Being a central element of the drive train, they are relevant for the efficiency and durability of motor vehicles. In this work, we present a new approach for gearbox design: Modeling the design problem as a mixed-integer nonlinear program (MINLP) allows us to create gearbox designs from scratch for arbitrary requirements and—given enough time—to compute provably globally optimal designs for a given objective. We show how different degrees of freedom influence the runtime and present an exemplary solution.}, language = {en} } @incollection{JordanKatzPieper2021, author = {Jordan, Frank and Katz, Christiane and Pieper, Martin}, title = {Online-Kollaboration in der Mathematik: Ein Design-Based-Research-Projekt}, series = {Forschungsimpulse f{\"u}r hybrides Lehren und Lernen an Hochschulen}, booktitle = {Forschungsimpulse f{\"u}r hybrides Lehren und Lernen an Hochschulen}, publisher = {TH K{\"o}ln}, address = {K{\"o}ln}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:832-cos4-9465}, pages = {245 -- 261}, year = {2021}, abstract = {Die Studie er{\"o}rtert anhand eines Fallbeispiels aus der Mathematik f{\"u}r Ingenieur*innen, wie didaktische Gestaltungsprinzipien f{\"u}r Soziale Pr{\"a}senz, Kollaboration und das L{\"o}sen von praxisnahen Problemen mit mathematischem Denken in einer Online-Umgebung aussehen k{\"o}nnen. Hierf{\"u}r zieht der Beitrag den forschungsmethodologischen Rahmen Design-Based Research (DBR) hinzu und berichtet {\"u}ber Zwischenergebnisse. DBR wird an dieser Stelle als eine systematische Herangehensweise an kurzfristige Lehrver{\"a}nderungen und als Chance auf dem Weg zu einer neuen Hochschullehre nach der COVID-19-Pandemie dargestellt, die theoretische und empirische Erkenntnisse mit Praxisverkn{\"u}pfung und -relevanz vereint.}, language = {de} } @incollection{Kotliar2021, author = {Kotliar, Konstantin}, title = {Ocular rigidity: clinical approach}, series = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye}, booktitle = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye}, editor = {Pallikaris, I. and Tsilimbaris, M. K. and Dastiridou, A. I.}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-64422-2}, doi = {10.1007/978-3-030-64422-2_2}, pages = {15 -- 43}, year = {2021}, abstract = {The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications.}, language = {en} } @incollection{AltherrEdererLorenzetal.2016, author = {Altherr, Lena and Ederer, Thorsten and Lorenz, Ulf and Pelz, Peter F. and P{\"o}ttgen, Philipp}, title = {Designing a feedback control system via mixed-integer programming}, series = {Operations Research Proceedings 2014: Selected Papers of the Annual International Conference of the German Operations Research}, booktitle = {Operations Research Proceedings 2014: Selected Papers of the Annual International Conference of the German Operations Research}, editor = {L{\"u}bbecke, Marco E. and Koster, Arie and Letmathe, Peter and Madlener, Reihard and Preis, Britta and Walther, Grit}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-28695-2}, doi = {10.1007/978-3-319-28697-6_18}, pages = {121 -- 127}, year = {2016}, abstract = {Pure analytical or experimental methods can only find a control strategy for technical systems with a fixed setup. In former contributions we presented an approach that simultaneously finds the optimal topology and the optimal open-loop control of a system via Mixed Integer Linear Programming (MILP). In order to extend this approach by a closed-loop control we present a Mixed Integer Program for a time discretized tank level control. This model is the basis for an extension by combinatorial decisions and thus for the variation of the network topology. Furthermore, one is able to appraise feasible solutions using the global optimality gap.}, language = {en} } @incollection{LeiseAltherrPelz2018, author = {Leise, Philipp and Altherr, Lena and Pelz, Peter F.}, title = {Energy-Efficient design of a water supply system for skyscrapers by mixed-integer nonlinear programming}, series = {Operations Research Proceedings 2017}, booktitle = {Operations Research Proceedings 2017}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-89919-0}, doi = {10.1007/978-3-319-89920-6_63}, year = {2018}, abstract = {The energy-efficiency of technical systems can be improved by a systematic design approach. Technical Operations Research (TOR) employs methods known from Operations Research to find a global optimal layout and operation strategy of technical systems. We show the practical usage of this approach by the systematic design of a decentralized water supply system for skyscrapers. All possible network options and operation strategies are modeled by a Mixed-Integer Nonlinear Program. We present the optimal system found by our approach and highlight the energy savings compared to a conventional system design.}, language = {en} } @incollection{StengerAltherrMuelleretal.2018, author = {Stenger, David and Altherr, Lena and M{\"u}ller, Tankred and Pelz, Peter F.}, title = {Product family design optimization using model-based engineering techniques}, series = {Operations Research Proceedings 2017}, booktitle = {Operations Research Proceedings 2017}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-89919-0}, doi = {10.1007/978-3-319-89920-6_66}, pages = {495 -- 502}, year = {2018}, abstract = {Highly competitive markets paired with tremendous production volumes demand particularly cost efficient products. The usage of common parts and modules across product families can potentially reduce production costs. Yet, increasing commonality typically results in overdesign of individual products. Multi domain virtual prototyping enables designers to evaluate costs and technical feasibility of different single product designs at reasonable computational effort in early design phases. However, savings by platform commonality are hard to quantify and require detailed knowledge of e.g. the production process and the supply chain. Therefore, we present and evaluate a multi-objective metamodel-based optimization algorithm which enables designers to explore the trade-off between high commonality and cost optimal design of single products.}, language = {en} } @incollection{MuellerAltherrAholaetal.2018, author = {M{\"u}ller, Tim M. and Altherr, Lena and Ahola, Marja and Schabel, Samuel and Pelz, Peter F.}, title = {Optimizing pressure screen systems in paper recycling: optimal system layout, component selection and operation}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-18499-5}, doi = {10.1007/978-3-030-18500-8_44}, pages = {355 -- 361}, year = {2018}, abstract = {Around 60\% of the paper worldwide is made from recovered paper. Especially adhesive contaminants, so called stickies, reduce paper quality. To remove stickies but at the same time keep as many valuable fibers as possible, multi-stage screening systems with several interconnected pressure screens are used. When planning such systems, suitable screens have to be selected and their interconnection as well as operational parameters have to be defined considering multiple conflicting objectives. In this contribution, we present a Mixed-Integer Nonlinear Program to optimize system layout, component selection and operation to find a suitable trade-off between output quality and yield.}, language = {en} } @incollection{StengerAltherrAbel2019, author = {Stenger, David and Altherr, Lena and Abel, Dirk}, title = {Machine learning and metaheuristics for black-box optimization of product families: a case-study investigating solution quality vs. computational overhead}, series = {Operations Research Proceedings 2018}, booktitle = {Operations Research Proceedings 2018}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-18499-5 (Print)}, doi = {10.1007/978-3-030-18500-8_47}, pages = {379 -- 385}, year = {2019}, abstract = {In product development, numerous design decisions have to be made. Multi-domain virtual prototyping provides a variety of tools to assess technical feasibility of design options, however often requires substantial computational effort for just a single evaluation. A special challenge is therefore the optimal design of product families, which consist of a group of products derived from a common platform. Finding an optimal platform configuration (stating what is shared and what is individually designed for each product) and an optimal design of all products simultaneously leads to a mixed-integer nonlinear black-box optimization model. We present an optimization approach based on metamodels and a metaheuristic. To increase computational efficiency and solution quality, we compare different types of Gaussian process regression metamodels adapted from the domain of machine learning, and combine them with a genetic algorithm. We illustrate our approach on the example of a product family of electrical drives, and investigate the trade-off between solution quality and computational overhead.}, language = {en} } @incollection{LeiseAltherrSimonetal.2019, author = {Leise, Philipp and Altherr, Lena and Simon, Nicolai and Pelz, Peter F.}, title = {Finding global-optimal gearbox designs for battery electric vehicles}, series = {Optimization of complex systems - theory, models, algorithms and applications : WCGO 2019}, booktitle = {Optimization of complex systems - theory, models, algorithms and applications : WCGO 2019}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-21802-7}, doi = {10.1007/978-3-030-21803-4_91}, pages = {916 -- 925}, year = {2019}, abstract = {In order to maximize the possible travel distance of battery electric vehicles with one battery charge, it is mandatory to adjust all components of the powertrain carefully to each other. While current vehicle designs mostly simplify the powertrain rigorously and use an electric motor in combination with a gearbox with only one fixed transmission ratio, the use of multi-gear systems has great potential. First, a multi-speed system is able to improve the overall energy efficiency. Secondly, it is able to reduce the maximum momentum and therefore to reduce the maximum current provided by the traction battery, which results in a longer battery lifetime. In this paper, we present a systematic way to generate multi-gear gearbox designs that—combined with a certain electric motor—lead to the most efficient fulfillment of predefined load scenarios and are at the same time robust to uncertainties in the load. Therefore, we model the electric motor and the gearbox within a Mixed-Integer Nonlinear Program, and optimize the efficiency of the mechanical parts of the powertrain. By combining this mathematical optimization program with an unsupervised machine learning algorithm, we are able to derive global-optimal gearbox designs for practically relevant momentum and speed requirements.}, language = {en} } @incollection{PfetschAbeleAltherretal.2021, author = {Pfetsch, Marc E. and Abele, Eberhard and Altherr, Lena and B{\"o}lling, Christian and Br{\"o}tz, Nicolas and Dietrich, Ingo and Gally, Tristan and Geßner, Felix and Groche, Peter and Hoppe, Florian and Kirchner, Eckhard and Kloberdanz, Hermann and Knoll, Maximilian and Kolvenbach, Philip and Kuttich-Meinlschmidt, Anja and Leise, Philipp and Lorenz, Ulf and Matei, Alexander and Molitor, Dirk A. and Niessen, Pia and Pelz, Peter F. and Rexer, Manuel and Schmitt, Andreas and Schmitt, Johann M. and Schulte, Fiona and Ulbrich, Stefan and Weigold, Matthias}, title = {Strategies for mastering uncertainty}, series = {Mastering uncertainty in mechanical engineering}, booktitle = {Mastering uncertainty in mechanical engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-78353-2}, doi = {10.1007/978-3-030-78354-9_6}, pages = {365 -- 456}, year = {2021}, abstract = {This chapter describes three general strategies to master uncertainty in technical systems: robustness, flexibility and resilience. It builds on the previous chapters about methods to analyse and identify uncertainty and may rely on the availability of technologies for particular systems, such as active components. Robustness aims for the design of technical systems that are insensitive to anticipated uncertainties. Flexibility increases the ability of a system to work under different situations. Resilience extends this characteristic by requiring a given minimal functional performance, even after disturbances or failure of system components, and it may incorporate recovery. The three strategies are described and discussed in turn. Moreover, they are demonstrated on specific technical systems.}, language = {en} } @incollection{HoffschmidtAlexopoulosRauetal.2021, author = {Hoffschmidt, Bernhard and Alexopoulos, Spiros and Rau, Christoph and Sattler, Johannes, Christoph and Anthrakidis, Anette and Teixeira Boura, Cristiano Jos{\´e} and O'Connor, B. and Caminos, R.A. Chico and Rend{\´o}n, C. and Hilger, P.}, title = {Concentrating Solar Power}, series = {Earth systems and environmental sciences}, booktitle = {Earth systems and environmental sciences}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-12-409548-9}, doi = {10.1016/B978-0-12-819727-1.00089-3}, year = {2021}, abstract = {The focus of this chapter is the production of power and the use of the heat produced from concentrated solar thermal power (CSP) systems. The chapter starts with the general theoretical principles of concentrating systems including the description of the concentration ratio, the energy and mass balance. The power conversion systems is the main part where solar-only operation and the increase in operational hours. Solar-only operation include the use of steam turbines, gas turbines, organic Rankine cycles and solar dishes. The operational hours can be increased with hybridization and with storage. Another important topic is the cogeneration where solar cooling, desalination and of heat usage is described. Many examples of commercial CSP power plants as well as research facilities from the past as well as current installed and in operation are described in detail. The chapter closes with economic and environmental aspects and with the future potential of the development of CSP around the world.}, language = {en} } @incollection{EngelmannShashaSlabu2021, author = {Engelmann, Ulrich M. and Shasha, Carolyn and Slabu, Ioana}, title = {Magnetic nanoparticle relaxation in biomedical application: focus on simulating nanoparticle heating}, series = {Magnetic nanoparticles in human health and medicine}, booktitle = {Magnetic nanoparticles in human health and medicine}, publisher = {Wiley-Blackwell}, address = {Hoboken, New Jeersey}, isbn = {978-1-119-75467-1}, pages = {327 -- 354}, year = {2021}, language = {en} } @incollection{ButenwegGellertMeyer2021, author = {Butenweg, Christoph and Gellert, Christoph and Meyer, Udo}, title = {Erdbebenbemessung bei Mauerwerksbauten}, series = {Mauerwerk Kalender 2021: Kunststoffverankerungen Digitalisierung im Mauerwerksbau}, booktitle = {Mauerwerk Kalender 2021: Kunststoffverankerungen Digitalisierung im Mauerwerksbau}, publisher = {Ernst \& Sohn}, address = {Berlin}, isbn = {9783433032930}, doi = {10.1002/9783433610732.ch12}, pages = {329 -- 355}, year = {2021}, abstract = {Der vorliegende Beitrag stellt den seismischen Nachweis von Mauerwerksbauten in Deutschland auf Grundlage der DIN EN 1998-1/NA vor, wobei auch die wesentlichen {\"A}nderungen zu der Norm DIN 4149 vergleichend erl{\"a}utert werden. Vorgestellt werden die Definition der Erdbebeneinwirkung, das seismische Verhalten von Mauerwerksbauten und die Erl{\"a}uterung der Rechenverfahren. Darauf aufbauend wird die Anwendung an drei Praxisbeispielen demonstriert.}, language = {de} } @incollection{AkimbekovDigelRazzaque2022, author = {Akimbekov, Nuraly S. and Digel, Ilya and Razzaque, Mohammed S.}, title = {Role of vitamins in maintaining structure and function of intestinal microbiome}, series = {Comprehensive Gut Microbiota}, booktitle = {Comprehensive Gut Microbiota}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-12-822036-8}, doi = {10.1016/B978-0-12-819265-8.00043-7}, pages = {320 -- 334}, year = {2022}, abstract = {The recent advances in microbiology have shed light on understanding the role of vitamins beyond the nutritional range. Vitamins are critical in contributing to healthy biodiversity and maintaining the proper function of gut microbiota. The sharing of vitamins among bacterial populations promotes stability in community composition and diversity; however, this balance becomes disturbed in various pathologies. Here, we overview and analyze the ability of different vitamins to selectively and specifically induce changes in the intestinal microbial community. Some schemes and regularities become visible, which may provide new insights and avenues for therapeutic management and functional optimization of the gut microbiota.}, language = {en} } @incollection{EngemannDuKallweitetal.2020, author = {Engemann, Heiko and Du, Shengzhi and Kallweit, Stephan and Ning, Chuanfang and Anwar, Saqib}, title = {AutoSynPose: Automatic Generation of Synthetic Datasets for 6D Object Pose Estimation}, series = {Machine Learning and Artificial Intelligence. Proceedings of MLIS 2020}, booktitle = {Machine Learning and Artificial Intelligence. Proceedings of MLIS 2020}, publisher = {IOS Press}, address = {Amsterdam}, isbn = {978-1-64368-137-5}, doi = {10.3233/FAIA200770}, pages = {89 -- 97}, year = {2020}, abstract = {We present an automated pipeline for the generation of synthetic datasets for six-dimension (6D) object pose estimation. Therefore, a completely automated generation process based on predefined settings is developed, which enables the user to create large datasets with a minimum of interaction and which is feasible for applications with a high object variance. The pipeline is based on the Unreal 4 (UE4) game engine and provides a high variation for domain randomization, such as object appearance, ambient lighting, camera-object transformation and distractor density. In addition to the object pose and bounding box, the metadata includes all randomization parameters, which enables further studies on randomization parameter tuning. The developed workflow is adaptable to other 3D objects and UE4 environments. An exemplary dataset is provided including five objects of the Yale-CMU-Berkeley (YCB) object set. The datasets consist of 6 million subsegments using 97 rendering locations in 12 different UE4 environments. Each dataset subsegment includes one RGB image, one depth image and one class segmentation image at pixel-level.}, language = {en} } @incollection{ZhubanovaMansurovDigel2020, author = {Zhubanova, Azhar A. and Mansurov, Zulkhair A. and Digel, Ilya}, title = {Use of Advanced Nanomaterials for Bioremediation of Contaminated Ecosystems}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing}, address = {Singapore}, isbn = {978-981-4800-27-3}, doi = {10.1201/9780429428647-18}, pages = {353 -- 378}, year = {2020}, abstract = {This chapter shows that nanomaterials obtained by high-temperature carbonization of inexpensive plant raw material such as rice husk, grape seeds, and walnut shells can serve as a basis for the production of highly efficient microbial drugs, biodestructors, biosorbents, and biocatalysts, which are promising for the remediation of the ecosystem contaminated with heavy and radioactive metals, oil and oil products. A strong interest in engineering zymology is dictated by the necessity to address the issues of monitoring enzymatic processes, treatment, and diagnosis of a number of common human diseases, environmental pollution, quality control of pharmaceuticals and food. Nanomaterials obtained by high-temperature carbonization of cheap plant raw material such as-rice husks, grape seeds and walnut shells, can serve as a basis for creating of highly effective microbial preparations-biodestructors, biosorbents and biocatalysts, which are promising for the use of contaminated ecosystems, and for restoration of human intestine microecology.}, language = {en} } @incollection{SavitskayaKistaubayevaAkimbekovetal.2020, author = {Savitskaya, Irina S. and Kistaubayeva, Aida S. and Akimbekov, Nuraly and Digel, Ilya and Shokatayeva, Dina and Zhubanova, Azhar Achmet}, title = {Prospective Use of Probiotics Immobilized on Sorbents with Nanostructured Surfaces}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing}, address = {Singapore}, isbn = {978-981-4800-27-3}, doi = {10.1201/9780429428647-12}, pages = {229 -- 267}, year = {2020}, abstract = {Activated carbons are known as excellent adsorbents. Their applications include the adsorptive removal of color, odor, taste, undesirable organic and inorganic pollutants from drinking and waste water; air purification in inhabited spaces; purification of many chemicals, pharmaceutical products and many others. This chapter elucidates the role of normal microflora in the maintenance of human health and presents materials on possible clinical displays of microecological infringements and ways of their correction. It presents new developments concerning new probiotics with immobilized Lactobacillus and Bacillus. The chapter considers the mechanisms of the intestine disbacteriosis correction by sorbed probiotics. It demonstrates the advantages and creation prospects of immobilized probiotics developed on the basis of carbonized rice husk. There are great prospects for the development of medical biotechnology due to use of carbon sorbents with a nanostructured surface. Microbial communities form a biocenosis of the biotope and together with the host organism create permanent or temporary ecosystems.}, language = {en} } @incollection{AkimbekovZhanadilovnaUalievaetal.2020, author = {Akimbekov, Nuraly and Zhanadilovna, Abdieva G. and Ualieva, Perizat S. and Abaihanovna, Zhusipova D. and Digel, Ilya and Savitskaya, Irina S. and Zhubanova, Azhar Achmet}, title = {Functionalization of Carbon Based Wound Dressings with Antimicrobial Phytoextracts for Bioactive Treatment of Septic Wounds}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing}, address = {Singapore}, isbn = {978-981-4800-27-3}, doi = {10.1201/9780429428647-11}, pages = {211 -- 228}, year = {2020}, abstract = {The treatment of septic wounds with curative dressings based on biocomposites containing sage and marigold phytoextracts was effective in in vitro and in vivo experiments. These dressings caused the purification of the wound surface from purulent-necrotic masses three days earlier than in the other experimental groups. The consequence of an increase in incidents of severe course of the wound and the observed tendency to increase the number of adverse effects is the development of long-term recurrent wound processes. To treat purulent wounds, the following tactics were used: The purulent wounds of animals were covered with the examined wound dressing, and then the next day samples were taken, the procedure was performed once in 2 days. To obtain the active nanostructured sorbents such as carbonized rice husks, they are functionalized with biologically active components possessing antimicrobial, anti-inflammatory, antitoxic, immunomodulating, antiallergic and other types of properties.}, language = {en} } @incollection{MansurovJandosovChenchiketal.2020, author = {Mansurov, Zulkhair A. and Jandosov, Jakpar and Chenchik, D. and Azat, Seitkhan and Savitskaya, Irina S. and Kistaubaeva, Aida and Akimbekov, Nuraly and Digel, Ilya and Zhubanova, Azhar Achmet}, title = {Biocomposite Materials Based on Carbonized Rice Husk in Biomedicine and Environmental Applications}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing Pte. Ltd.}, address = {Singapore}, isbn = {978-981-4800-27-3}, doi = {10.1201/9780429428647-2}, pages = {3 -- 32}, year = {2020}, abstract = {This chapter describes the prospects for biomedical and environmental engineering applications of heterogeneous materials based on nanostructured carbonized rice husk. Efforts in engineering enzymology are focused on the following directions: development and optimization of immobilization methods leading to novel biotechnological and biomedical applications; construction of biocomposite materials based on individual enzymes, multi-enzyme complexes and whole cells, targeted on realization of specific industrial processes. Molecular biological and biochemical studies on cell adhesion focus predominantly on identification, isolation and structural analysis of attachment-responsible biological molecules and their genetic determinants. The chapter provides a short overview of applications of the biocomposite materials based of nanostructured carbonized adsorbents. It emphasizes that further studies and better understanding of the interactions between CNS and microbial cells are necessary. The future use of living cells as biocatalysts, especially in the environmental field, needs more systematic investigations of the microbial adsorption phenomenon.}, language = {en} } @incollection{ButenwegEbenau1996, author = {Butenweg, Christoph and Ebenau, C.}, title = {Entwicklung eines objekt-orientierten FE-Programms}, series = {Forum Bauinformatik - Junge Wissenschaftler forschen, Cottbus '96}, booktitle = {Forum Bauinformatik - Junge Wissenschaftler forschen, Cottbus '96}, publisher = {VDI-Verlag}, address = {D{\"u}sseldorf}, isbn = {978-3-18-313504-2}, pages = {60 -- 65}, year = {1996}, language = {de} } @incollection{Butenweg2017, author = {Butenweg, Christoph}, title = {Passt, wackelt und hat Luft: Mauerwerksbauten aus Leichtbeton in Erdbebengebieten}, series = {Beton-Bauteile, 65. Ausgabe (2017): Entwerfen - Planen - Ausf{\"u}hren}, booktitle = {Beton-Bauteile, 65. Ausgabe (2017): Entwerfen - Planen - Ausf{\"u}hren}, publisher = {Bauverl.}, address = {G{\"u}tersloh}, isbn = {978-3-7625-3676-5}, pages = {136 -- 140}, year = {2017}, language = {de} } @incollection{ButenwegKubalskiMarinkovicetal.2016, author = {Butenweg, Christoph and Kubalski, Thomas and Marinkovic, Marko and Pfetzing, Thomas and Ismail, Mohammed and Fehling, Ekkehard}, title = {Ausfachungen aus Ziegelmauerwerk}, series = {Mauerwerk-Kalender 2016: Baustoffe, Sanierung, Eurocode-Praxis}, booktitle = {Mauerwerk-Kalender 2016: Baustoffe, Sanierung, Eurocode-Praxis}, publisher = {Ernst \& Sohn}, address = {Berlin}, isbn = {978-3-433-03131-5}, year = {2016}, language = {de} } @incollection{ButenwegBollenbeck2003, author = {Butenweg, Christoph and Bollenbeck, S.}, title = {Mauerwerksbauten unter Erdbebenbelastung}, series = {Bauwerke und Erdbeben}, booktitle = {Bauwerke und Erdbeben}, publisher = {Vieweg}, address = {Wiesbaden}, isbn = {3-528-02574-3}, pages = {385 -- 397}, year = {2003}, language = {de} } @incollection{FateriGebhardt2020, author = {Fateri, Miranda and Gebhardt, Andreas}, title = {Introduction to Additive Manufacturing}, series = {3D Printing of Optical Components}, booktitle = {3D Printing of Optical Components}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-58960-8}, doi = {10.1007/978-3-030-58960-8_1}, pages = {1 -- 22}, year = {2020}, abstract = {Additive manufacturing (AM) works by creating objects layer by layer in a manner similar to a 2D printer with the "printed" layers stacked on top of each other. The layer-wise manufacturing nature of AM enables fabrication of freeform geometries which cannot be fabricated using conventional manufacturing methods as a one part. Depending on how each layer is created and bonded to the adjacent layers, different AM methods have been developed. In this chapter, the basic terms, common materials, and different methods of AM are described, and their potential applications are discussed.}, language = {en} } @incollection{BozakovSander2013, author = {Bozakov, Zdravko and Sander, Volker}, title = {OpenFlow: A Perspective for Building Versatile Networks}, series = {Network-Embedded Management and Applications}, booktitle = {Network-Embedded Management and Applications}, publisher = {Springer}, address = {New York, NY}, isbn = {978-1-4419-6769-5}, doi = {10.1007/978-1-4419-6769-5_11}, pages = {217 -- 245}, year = {2013}, language = {en} } @incollection{Blome2013, author = {Blome, Hans-Joachim}, title = {Die Tragweite der physikalischen Kosmologie}, series = {Exploring Uncertainty}, booktitle = {Exploring Uncertainty}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-658-00897-0}, doi = {10.1007/978-3-658-00897-0_6}, pages = {105 -- 150}, year = {2013}, language = {de} } @incollection{GebhardtHoetter2019, author = {Gebhardt, Andreas and Hoetter, Jan-Steffen}, title = {Rapid Tooling}, series = {CIRP Encyclopedia of Production Engineering}, booktitle = {CIRP Encyclopedia of Production Engineering}, publisher = {Springer}, address = {Berlin, Heidelberg}, isbn = {978-3-662-53120-4}, doi = {10.1007/978-3-662-53120-4}, pages = {39 -- 52}, year = {2019}, language = {en} } @incollection{IbanezSanchezWolf2020, author = {Ibanez-Sanchez, Gema and Wolf, Martin}, title = {Interactive Process Mining-Induced Change Management Methodology for Healthcare}, series = {Interactive Process Mining in Healthcare}, booktitle = {Interactive Process Mining in Healthcare}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-53993-1 (Online)}, doi = {10.1007/978-3-030-53993-1_16}, pages = {267 -- 293}, year = {2020}, abstract = {The adoption of the Digital Health Transformation is a tremendous paradigm change in health organizations, which is not a trivial process in reality. For that reason, in this chapter, it is proposed a methodology with the objective to generate a changing culture in healthcare organisations. Such a change culture is essential for the successful implementation of any supporting methods like Interactive Process Mining. It needs to incorporate (mostly) new ways of team-based and evidence-based approaches for solving structural problems in a digital healthcare environment.}, language = {en} } @incollection{GiresiniButenweg2019, author = {Giresini, Linda and Butenweg, Christoph}, title = {Earthquake resistant design of structures according to Eurocode 8}, series = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, booktitle = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-57550-5 (Online)}, doi = {10.1007/978-3-662-57550-5_4}, pages = {197 -- 358}, year = {2019}, abstract = {The chapter initially provides a summary of the contents of Eurocode 8, its aim being to offer both to the students and to practising engineers an easy introduction into the calculation and dimensioning procedures of this earthquake code. Specifically, the general rules for earthquake-resistant structures, the definition of design response spectra taking behaviour and importance factors into account, the application of linear and non-linear calculation methods and the structural safety verifications at the serviceability and ultimate limit state are presented. The application of linear and non-linear calculation methods and corresponding seismic design rules is demonstrated on practical examples for reinforced concrete, steel and masonry buildings. Furthermore, the seismic assessment of existing buildings is discussed and illustrated on the example of a typical historical masonry building in Italy. The examples are worked out in detail and each step of the design process, from the preliminary analysis to the final design, is explained in detail.}, language = {en} } @incollection{ButenwegHoltschoppen2019, author = {Butenweg, Christoph and Holtschoppen, Britta}, title = {Seismic design of structures and components in industrial units}, series = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, booktitle = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-57550-5}, doi = {10.1007/978-3-662-57550-5_5}, pages = {359 -- 481}, year = {2019}, abstract = {Industrial units consist of the primary load-carrying structure and various process engineering components, the latter being by far the most important in financial terms. In addition, supply structures such as free-standing tanks and silos are usually required for each plant to ensure the supply of material and product storage. Thus, for the earthquake-proof design of industrial plants, design and construction rules are required for the primary structures, the secondary structures and the supply structures. Within the framework of these rules, possible interactions of primary and secondary structures must also be taken into account. Importance factors are used in seismic design in order to take into account the usually higher risk potential of an industrial unit compared to conventional building structures. Industrial facilities must be able to withstand seismic actions because of possibly wide-ranging damage consequences in addition to losses due to production standstill and the destruction of valuable equipment. The chapter presents an integrated concept for the seismic design of industrial units based on current seismic standards and the latest research results. Special attention is devoted to the seismic design of steel thin-walled silos and tank structures.}, language = {en} } @incollection{Laack2020, author = {Laack, Walter van}, title = {Twee Kanten van {\´e}{\´e}n Medaille}, series = {Het Geheim van Elysion : 45 Jaar Studies naar Nabij-de-Dood-Ervaringen over Bewustzijn in Liefde zonder Waarheen}, booktitle = {Het Geheim van Elysion : 45 Jaar Studies naar Nabij-de-Dood-Ervaringen over Bewustzijn in Liefde zonder Waarheen}, publisher = {Van Warven}, address = {Kampen}, isbn = {978-94-93175-44-0}, pages = {97 -- 105}, year = {2020}, language = {nl} } @incollection{AzatKerimkulovaMansurovetal.2020, author = {Azat, Seitkhan and Kerimkulova, Almagul R. and Mansurov, Zulkhair A. and Adekenov, Sergazy and Artmann, Gerhard}, title = {The Use of Fusicoccin as Anticancer Compound}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing}, address = {New York}, isbn = {978-0-429-42864-7}, doi = {10.1201/9780429428647-8}, pages = {149 -- 172}, year = {2020}, abstract = {The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.}, language = {en} } @incollection{Timme2020, author = {Timme, Michael}, title = {Kommentierung zu den \S\S 24 - 27}, series = {M{\"u}nchener Kommentar zum Wettbewerbsrecht Bd. 2: Gesetz gegen Wettbewerbsbeschr{\"a}nkungen (GWB) \S\S 1-96, 185, 186, Verfahren vor den europ{\"a}ischen Gerichten}, booktitle = {M{\"u}nchener Kommentar zum Wettbewerbsrecht Bd. 2: Gesetz gegen Wettbewerbsbeschr{\"a}nkungen (GWB) \S\S 1-96, 185, 186, Verfahren vor den europ{\"a}ischen Gerichten}, edition = {3. Auflage}, publisher = {C.H. Beck}, address = {M{\"u}nchen}, isbn = {978-3-406-72772-6}, year = {2020}, language = {de} } @incollection{Matcha2007, author = {Matcha, Heike}, title = {Parametrischer Geb{\"a}udeentwurf}, series = {Parametrik, Strategie, Produktion: Von der digitalen Planung zur technischen Umsetzung}, booktitle = {Parametrik, Strategie, Produktion: Von der digitalen Planung zur technischen Umsetzung}, editor = {Hauschild, Moritz and Karzel, R{\"u}diger}, publisher = {Technische Universit{\"a}t Darmstadt}, address = {Darmstadt}, pages = {14 -- 15}, year = {2007}, language = {de} } @incollection{Matcha2007, author = {Matcha, Heike}, title = {Vom Industriellen Bauen zu parametrischen Planungsprozessen}, series = {Parametrik, Strategie, Produktion: Von der digitalen Planung zur technischen Umsetzung}, booktitle = {Parametrik, Strategie, Produktion: Von der digitalen Planung zur technischen Umsetzung}, editor = {Hauschild, Moritz and Karzel, R{\"u}diger}, publisher = {Technische Universit{\"a}t Darmstadt}, address = {Darmstadt}, pages = {12 -- 13}, year = {2007}, language = {de} } @incollection{MatchaBarczikAgkathidis2009, author = {Matcha, Heike and Barczik, G{\"u}nter and Agkathidis, Asterios}, title = {Produktive Prozesse: Mehr Vielfalt, Komplexit{\"a}t und Kreativit{\"a}t im Entwerfen mittels parametrisierter generativer Algorithmen}, series = {Modulare Strukturen in Entwurf und Architektur}, booktitle = {Modulare Strukturen in Entwurf und Architektur}, publisher = {BIS-Publishers}, address = {Amsterdam}, isbn = {978-90-6369-208-7}, pages = {126 -- 130}, year = {2009}, language = {de} } @incollection{Matcha2010, author = {Matcha, Heike}, title = {Regelbasierte Planung - Parametrik}, series = {Digitale Prozesse : Planung, Gestaltung, Fertigung}, booktitle = {Digitale Prozesse : Planung, Gestaltung, Fertigung}, editor = {Hauschild, Moritz and Karzel, R{\"u}diger}, publisher = {Detail}, address = {M{\"u}nchen}, isbn = {978-3-95553-022-8}, doi = {10.11129/detail.9783955530228}, pages = {24 -- 24}, year = {2010}, language = {de} } @incollection{Matcha2010, author = {Matcha, Heike}, title = {Regelbasierte Planung - Parametrik}, series = {Digitale Prozesse: Planung, Gestaltung, Fertigung}, booktitle = {Digitale Prozesse: Planung, Gestaltung, Fertigung}, editor = {Hauschild, Moritz and Karzel, R{\"u}diger}, publisher = {Ed. Detail}, address = {M{\"u}nchen}, isbn = {978-3-920034-35-5}, pages = {24 -- 24}, year = {2010}, language = {de} } @incollection{MatchaBarczik2011, author = {Matcha, Heike and Barczik, G{\"u}nter}, title = {Mass Diversity: Individualized housing via parametric typology}, series = {Structuralism Reloaded? Rule-Based Design in Architecture and Urbanism}, booktitle = {Structuralism Reloaded? Rule-Based Design in Architecture and Urbanism}, editor = {Valena, Tomas and Avermaete, Tom and Vrachliotis, Georg}, publisher = {Edition Axel Menges}, address = {Fellbach}, isbn = {978-3-936681-47-5}, pages = {354 -- 358}, year = {2011}, language = {en} } @incollection{MatchaKarzelPahl2013, author = {Matcha, Heike and Karzel, R{\"u}diger and Pahl, Katja-Annika}, title = {Lehre als Praxis als Forschung: 1:1 Entwicklung von Messest{\"a}nden unter Einsatz parametrisierter Software und computergesteuerter Herstellung}, series = {ECHT?! Zum Bezug von Praxis und Lehre in der Architekturausbildung}, booktitle = {ECHT?! Zum Bezug von Praxis und Lehre in der Architekturausbildung}, publisher = {TUDpress - Verlag der Wissenschaften}, address = {Dresden}, isbn = {978-3-94433111-9}, pages = {95 -- 108}, year = {2013}, language = {de} } @incollection{MuellerJungSchmoelzer2015, author = {Mueller, Wolfram and Jung, Alexander and Schm{\"o}lzer, Bernhard}, title = {Der Einfluss der H{\"o}he {\"u}ber dem Meeresspiegel auf die Flugbahnen im Schispringen}, series = {Jahrbuch 2015 - {\"O}sterreichische Gesellschaft f{\"u}r Alpin- und H{\"o}henmedizin}, booktitle = {Jahrbuch 2015 - {\"O}sterreichische Gesellschaft f{\"u}r Alpin- und H{\"o}henmedizin}, editor = {Faulhaber, Martin and Schobersberger, Wolfgang and Schobersberger, Beatrix and Sumann, G{\"u}nther and Domej, Wolfgang}, publisher = {{\"O}sterreichische Gesellschaft f{\"u}r Alpin- und H{\"o}henmedizin}, address = {Innsbruck}, isbn = {978-3-9501312-5-3}, pages = {173 -- 190}, year = {2015}, language = {de} } @incollection{RaoPathroseHueningetal.2019, author = {Rao, Deepak and Pathrose, Plato and H{\"u}ning, Felix and Sid, Jithin}, title = {An Approach for Validating Safety of Perception Software in Autonomous Driving Systems}, series = {Model-Based Safety and Assessment: 6th International Symposium, IMBSA 2019, Thessaloniki, Greece, October 16-18, 2019, Proceedings}, booktitle = {Model-Based Safety and Assessment: 6th International Symposium, IMBSA 2019, Thessaloniki, Greece, October 16-18, 2019, Proceedings}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-32872-6}, doi = {10.1007/978-3-030-32872-6_20}, pages = {303 -- 316}, year = {2019}, abstract = {The increasing complexity of Advanced Driver Assistance Systems (ADAS) presents a challenging task to validate safe and reliable performance of these systems under varied conditions. The test and validation of ADAS/AD with real test drives, although important, involves huge costs and time. Simulation tools provide an alternative with the added advantage of reproducibility but often use ideal sensors, which do not reflect real sensor output accurately. This paper presents a new validation methodology using fault injection, as recommended by the ISO 26262 standard, to test software and system robustness. In our work, we investigated and developed a tool capable of inserting faults at different software and system levels to verify its robustness. The scope of this paper is to cover the fault injection test for the Visteon's DriveCore™ system, a centralized domain controller for Autonomous driving which is sensor agnostic and SoC agnostic. With this new approach, the validation of safety monitoring functionality and its behavior can be tested using real-world data instead of synthetic data from simulation tools resulting in having better confidence in system performance before proceeding with in-vehicle testing.}, language = {en} } @incollection{BorchertTenbrake2020, author = {Borchert, J{\"o}rg and Tenbrake, Andre}, title = {Bewirtschaftung von Flexibilit{\"a}t {\"u}ber Microservices eines Plattformanbieters}, series = {Realisierung Utility 4.0 Band 1}, booktitle = {Realisierung Utility 4.0 Band 1}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-25332-5}, doi = {10.1007/978-3-658-25332-5_37}, pages = {615 -- 626}, year = {2020}, abstract = {Die Energiewirtschaft befindet sich in einem starken Wandel, der v. a. durch die Energiewende und Digitalisierung Druck auf s{\"a}mtliche Marktteilnehmer aus{\"u}bt. Das klassische Gesch{\"a}ftsmodell des Energieversorgungsunternehmens ver{\"a}ndert sich dabei grundlegend. Der kontinuierlich ansteigende Einsatz dezentraler und volatiler Erzeugungsanlagen macht die Identifikation von Flexibilit{\"a}tspotenzialen notwendig, um weiterhin eine hohe Versorgungssicherheit zu gew{\"a}hrleisten. Dieser Schritt ist nur mit einem hohen Digitalisierungsgrad m{\"o}glich. Eine funktionale Plattform mit Microservices, die zu Gesch{\"a}ftsprozessen verbunden werden k{\"o}nnen, wird als M{\"o}glichkeit zur Aktivierung der Flexibilit{\"a}t und Digitalisierung der Energieversorgungsunternehmen im Folgenden vorgestellt.}, language = {de} } @incollection{ErnhardtDrummvanGogetal.2019, author = {Ernhardt, Selina and Drumm, Christian and van Gog, Tamara and Brand-Gruwel, Saskia and Jarodzka, Halszka}, title = {Through the eyes of a programmer : a research project on how to foster programming education with eye-tracking technology}, series = {Tagungsband zur 32. AKWI-Jahrestagung vom 15.09.2019 bis 18.09.2019 an der Fachhochschule f{\"u}r Angewandte Wissenschaften Aachen}, booktitle = {Tagungsband zur 32. AKWI-Jahrestagung vom 15.09.2019 bis 18.09.2019 an der Fachhochschule f{\"u}r Angewandte Wissenschaften Aachen}, publisher = {Mana-Buch}, address = {Heide}, isbn = {978-3-944330-62-4}, pages = {42 -- 47}, year = {2019}, language = {en} } @incollection{FiedlerHennMelcher2015, author = {Fiedler, Gerda and Henn, Gudrun and Melcher, Karin}, title = {ANPAK - Ein Anpassungskurs f{\"u}r Studienanf{\"a}nger in den Ingenieurwissenschaften}, series = {Qualifizierung von Studierenden im Student-Life-Cycle. Tagungsband zum Mosbacher Tag der Lehre am 23.10.2014 /}, booktitle = {Qualifizierung von Studierenden im Student-Life-Cycle. Tagungsband zum Mosbacher Tag der Lehre am 23.10.2014 /}, editor = {Morschheuser, Petra}, publisher = {Duale Hochschule Baden-W{\"u}rttemberg (DHBW)}, address = {Mosbach}, isbn = {978-3-943656-02-2}, pages = {90 -- 93}, year = {2015}, language = {de} } @incollection{Finkenberger2018, author = {Finkenberger, Isabel Maria}, title = {Schwellenreiten}, series = {Prozesse reflexiven Entwerfens : Entwerfen und Forschen in Architektur und Landschaft}, booktitle = {Prozesse reflexiven Entwerfens : Entwerfen und Forschen in Architektur und Landschaft}, editor = {Buchert, Margitta}, publisher = {JOVIS Verlag}, address = {Berlin}, isbn = {978-3-86859-558-1}, pages = {208 -- 226}, year = {2018}, language = {de} } @incollection{FinkenbergerBaumeister2017, author = {Finkenberger, Isabel Maria and Baumeister, Eva-Maria}, title = {Working in between : Die Stadt von der anderen Seite sehen : Where Urban Planning Meets Artistic Practice}, series = {New Stakeholders of Urban Change : A Question of Culture and Attitude?. - (Perspectives in Metropolitan Research ; IV)}, booktitle = {New Stakeholders of Urban Change : A Question of Culture and Attitude?. - (Perspectives in Metropolitan Research ; IV)}, editor = {Berger, Hilke Marit and Ziemer, Gesa}, publisher = {JOVIS Verlag}, address = {Berlin}, isbn = {978-3-86859-487-4}, pages = {119 -- 129}, year = {2017}, language = {de} } @incollection{FinkenbergerBaumeisterKoch2019, author = {Finkenberger, Isabel Maria and Baumeister, Eva-Maria and Koch, Christian}, title = {Themen}, series = {Komplement und Verst{\"a}rker: zum Verh{\"a}ltnis von Stadtplanung, k{\"u}nstlerischen Praktiken und Kulturinstitutionen}, booktitle = {Komplement und Verst{\"a}rker: zum Verh{\"a}ltnis von Stadtplanung, k{\"u}nstlerischen Praktiken und Kulturinstitutionen}, publisher = {JOVIS Verlag}, address = {Berlin}, isbn = {978-3-86859-578-9}, pages = {50 -- 57}, year = {2019}, language = {de} } @incollection{FinkenbergerHerbertMalornyetal.2019, author = {Finkenberger, Isabel Maria and Herbert, Saskia and Malorny, Thomas and Koch, Christian}, title = {Perforierte Wirklichkeit und m{\"o}gliche Zuk{\"u}nfte : ein Gespr{\"a}ch}, series = {Komplement und Verst{\"a}rker : zum Verh{\"a}ltnis von Stadtplanung, k{\"u}nstlerischen Praktiken und Kulturinstitutionen}, booktitle = {Komplement und Verst{\"a}rker : zum Verh{\"a}ltnis von Stadtplanung, k{\"u}nstlerischen Praktiken und Kulturinstitutionen}, publisher = {JOVIS Verlag}, address = {Berlin}, isbn = {978-3-86859-578-9}, pages = {108 -- 129}, year = {2019}, language = {de} } @incollection{FinkenbergerBaumeisterKoch2019, author = {Finkenberger, Isabel Maria and Baumeister, Eva-Maria and Koch, Christian}, title = {Komplement und Verst{\"a}rker : der Diskurs geht weiter}, series = {Komplement und Verst{\"a}rker : zum Verh{\"a}ltnis von Stadtplanung, k{\"u}nstlerischen Praktiken und Kulturinstitutionen}, booktitle = {Komplement und Verst{\"a}rker : zum Verh{\"a}ltnis von Stadtplanung, k{\"u}nstlerischen Praktiken und Kulturinstitutionen}, publisher = {JOVIS Verlag}, address = {Berlin}, isbn = {978-3-86859-578-9}, pages = {40 -- 49}, year = {2019}, language = {de} } @incollection{FinkenbergerBaumeisterKoch2019, author = {Finkenberger, Isabel Maria and Baumeister, Eva-Maria and Koch, Christian}, title = {Komplement und Verst{\"a}rker : Wandel durch neue Allianzen}, series = {Komplement und Verst{\"a}rker : zum Verh{\"a}ltnis von Stadtplanung, k{\"u}nstlerischen Praktiken und Kulturinstitutionen}, booktitle = {Komplement und Verst{\"a}rker : zum Verh{\"a}ltnis von Stadtplanung, k{\"u}nstlerischen Praktiken und Kulturinstitutionen}, publisher = {JOVIS Verlag}, address = {Berlin}, isbn = {978-3-86859-578-9}, pages = {10 -- 39}, year = {2019}, language = {de} } @incollection{SchoeningWagnerPoghossianetal.2018, author = {Sch{\"o}ning, Michael Josef and Wagner, Torsten and Poghossian, Arshak and Miyamoto, K.I. and Werner, C.F. and Krause, S. and Yoshinobu, T.}, title = {Light-addressable potentiometric sensors for (bio-)chemical sensing and imaging}, series = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7}, booktitle = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {9780128097397}, pages = {295 -- 308}, year = {2018}, language = {en} } @incollection{Lemke2019, author = {Lemke, J{\"o}rg}, title = {Arbeitssicherheit}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, doi = {10.1007/978-3-658-23127-9_12}, pages = {335 -- 344}, year = {2019}, language = {de} } @incollection{Streit2019, author = {Streit, Wilfried}, title = {Kalkulation}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, doi = {10.1007/978-3-658-23127-9_11}, pages = {273 -- 334}, year = {2019}, language = {de} } @incollection{Martin2019, author = {Martin, Joachim}, title = {Betriebsorganisation}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, doi = {10.1007/978-3-658-23127-9_10}, pages = {255 -- 272}, year = {2019}, language = {de} } @incollection{Krause2019, author = {Krause, Thomas}, title = {Schalung und Ger{\"u}ste}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9 (Online)}, doi = {10.1007/978-3-658-23127-9_9}, pages = {241 -- 253}, year = {2019}, abstract = {Die grunds{\"a}tzliche Planung von Schalungsaufgaben wird heute in der Regel im Rahmen der Arbeitsvorbereitung von den entsprechenden Stabsabteilungen oder als Serviceleistung von den Schalungsherstellern mit Anwendung von spezieller Software und den technischen Unterlagen f{\"u}r die jeweiligen Schalungsger{\"a}te durchgef{\"u}hrt. Diese Programme und technischen Unterlagen stehen in der Regel auch den Mitarbeitern in der Bauleitung zur Verf{\"u}gung, werden dort aber eher seltener genutzt. Zur Anwendung auf der Baustelle stellen die Schalungshersteller neben den technischen Unterlagen Bemessungstabellen zur Verf{\"u}gung, welche die Auswahl und Dimensionierung einzelner Schalungen wesentlich erleichtern. Die nachfolgend aufgef{\"u}hrten Beispiele aus dem Bereich Schalung und Ger{\"u}ste beschreiben Aufgaben, die im Baustellenbetrieb auf die Bauleitung zu kommen k{\"o}nnen und auch ohne Unterst{\"u}tzung einer Stabsabteilung gel{\"o}st werden k{\"o}nnen.}, language = {de} } @incollection{Ulke2019, author = {Ulke, Bernd}, title = {Boden, Baugrube, Verbau}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9 (Online)}, doi = {10.1007/978-3-658-23127-9_8}, pages = {165 -- 239}, year = {2019}, abstract = {Im folgenden Kapitel werden die wichtigsten geotechnischen Nachweise sowie praxisnahe Beispiele f{\"u}r den Baubetrieb aufgef{\"u}hrt. Es wird im Wesentlichen auf die Bodenbeschreibung und Klassifikation nach DIN 18196 sowie nach DIN 18300 eingegangen, welche sowohl f{\"u}r die weiteren Berechnungen als auch f{\"u}r die Kalkulation von großer Bedeutung sind. Die aus der Praxis aufgef{\"u}hrten Beispiele verdeutlichen verschiedene Untersuchungs- und Auswertungsmethoden f{\"u}r direkte und indirekte Aufschl{\"u}sse, diese enthalten Labor- und Feldversuche, mit denen man die Verdichtbarkeit von B{\"o}den auswertet und quantifiziert, sowie viele andere Themenbereiche wie Erddruckberechnungen sowie Spannungs- und Setzungsberechnungen. Dar{\"u}ber hinaus werden exemplarisch bestimmte Verbauarten bez{\"u}glich ihrer Bemessung erl{\"a}utert. Es wird ebenfalls auf das Thema Wasserhaltung eingegangen und die erforderlichen Maßnahmen beschrieben, um bestimmte Versagensmechanismen - wie z.B. den hydraulischen Grundbruch - zu verhindern.}, language = {de} } @incollection{Krause2019, author = {Krause, Thomas}, title = {Baumaschinen}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, doi = {10.1007/978-3-658-23127-9_7}, pages = {155 -- 163}, year = {2019}, language = {de} } @incollection{Ulke2019, author = {Ulke, Bernd}, title = {Arbeitsvorbereitung und Ablaufplanung}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, doi = {10.1007/978-3-658-23127-9_6}, pages = {117 -- 154}, year = {2019}, language = {de} } @incollection{Krause2019, author = {Krause, Thomas}, title = {Bauabrechnung und Mengenermittlung}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, doi = {10.1007/978-3-658-23127-9_5}, pages = {101 -- 116}, year = {2019}, language = {de} } @incollection{Ulke2019, author = {Ulke, Bernd}, title = {Baukosten und Finanzierung}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, doi = {10.1007/978-3-658-23127-9_4}, pages = {89 -- 100}, year = {2019}, language = {de} } @incollection{Ulke2019, author = {Ulke, Bernd}, title = {Der baurechtliche Vertrag}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, pages = {63 -- 87}, year = {2019}, abstract = {Anhand von kurzen theoretischen Einf{\"u}hrungen werden anhand von Beispielen die wesentlichen Aspekte des baurechtlichen Vertrages erl{\"a}utert. Nach einer Einf{\"u}hrung {\"u}ber das Zustandekommen von (Bau-) Vertr{\"a}gen wird die f{\"u}r Streitf{\"a}lle unerl{\"a}ssliche Dokumentation auf Baustellen erl{\"a}utert. Hierbei werden Hinweise zur Erstellung von Protokollen, zum E-Mail bei Großprojekten und zur Dokumentation von Stundenlohnarbeiten gegeben. Des Weiteren wird eine Schriftverkehrsliste vorgestellt, die zur Nachverfolgung des Schriftverkehrs bei Großprojekten unerl{\"a}sslich ist. Anschließend werden die typischen Vertragsarten vorgestellt, die bei der Abwicklung von Großprojekten zu beachten sind und die Unterschiede werden durch Fallbeispiele erl{\"a}utert. Einen Schwerpunkt des Kapitels bilden auftragsnehmerseitige Verz{\"u}ge sowie mangelbehaftete Leistungen. Hier werden Hinweise gegeben, wie in den entsprechenden Situationen zu reagieren ist.}, language = {de} } @incollection{Sparla2019, author = {Sparla, Peter}, title = {Vermessung}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, doi = {10.1007/978-3-658-23127-9_2}, pages = {13 -- 61}, year = {2019}, language = {de} } @incollection{Martin2019, author = {Martin, Joachim}, title = {Bemessung von Baukonstruktionen}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9}, doi = {10.1007/978-3-658-23127-9_1}, pages = {1 -- 11}, year = {2019}, language = {de} } @incollection{DachwaldOhndorf2019, author = {Dachwald, Bernd and Ohndorf, Andreas}, title = {Global optimization of continuous-thrust trajectories using evolutionary neurocontrol}, series = {Modeling and Optimization in Space Engineering}, booktitle = {Modeling and Optimization in Space Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-10501-3}, doi = {10.1007/978-3-030-10501-3_2}, pages = {33 -- 57}, year = {2019}, abstract = {Searching optimal continuous-thrust trajectories is usually a difficult and time-consuming task. The solution quality of traditional optimal-control methods depends strongly on an adequate initial guess because the solution is typically close to the initial guess, which may be far from the (unknown) global optimum. Evolutionary neurocontrol attacks continuous-thrust optimization problems from the perspective of artificial intelligence and machine learning, combining artificial neural networks and evolutionary algorithms. This chapter describes the method and shows some example results for single- and multi-phase continuous-thrust trajectory optimization problems to assess its performance. Evolutionary neurocontrol can explore the trajectory search space more exhaustively than a human expert can do with traditional optimal-control methods. Especially for difficult problems, it usually finds solutions that are closer to the global optimum. Another fundamental advantage is that continuous-thrust trajectories can be optimized without an initial guess and without expert supervision.}, language = {en} } @incollection{RoethPielen2018, author = {R{\"o}th, Thilo and Pielen, Michael}, title = {Personal Public Vehicle - ein urbanes Fahrzeugkonzept f{\"u}r die „Shared Mobility" der Zukunft}, series = {Karosseriebautage Hamburg 2018, 16. ATZ-Fachtagung}, booktitle = {Karosseriebautage Hamburg 2018, 16. ATZ-Fachtagung}, publisher = {Springer Vieweg}, address = {Wiesbaden}, doi = {10.1007/978-3-658-22038-9_13}, pages = {189 -- 199}, year = {2018}, abstract = {Die urbane Mobilit{\"a}t ist im Wandel und insbesondere neue innovative Gesch{\"a}ftsmodelle werden einen wesentlichen Teil zur L{\"o}sung von k{\"u}nftigen Mobilit{\"a}tsbed{\"u}rfnissen beitragen. Die sogenannte „Shared Mobility" gilt aktuell neben der Elektrifizierung des Antriebes und autonomem Fahrzeugtechnologien als einer der wichtigsten Trendthemen in der Automobilindustrie. Neue Mobilit{\"a}tsdienstleistungen verlangen dabei verst{\"a}rkt auch neue Fahrzeugkonzepte.}, language = {de} } @incollection{MeskourisButenwegHinzenetal.2019, author = {Meskouris, Konstantin and Butenweg, Christoph and Hinzen, Klaus-G. and H{\"o}ffer, R{\"u}diger}, title = {Stochasticity of Wind Processes and Spectral Analysis of Structural Gust Response}, series = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, booktitle = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-57550-5 (Online)}, doi = {10.1007/978-3-662-57550-5_3}, pages = {153 -- 196}, year = {2019}, abstract = {Wind loads have great impact on many engineering structures. Wind storms often cause irreparable damage to the buildings which are exposed to it. Along with the earthquakes, wind represents one of the most common environmental load on structures and is relevant for limit state design. Modern wind codes indicate calculation procedures allowing engineers to deal with structural systems, which are susceptible to conduct wind-excited oscillations. In the codes approximate formulas for wind buffeting are specified which relate the dynamic problem to rather abstract parameter functions. The complete theory behind is not visible in order to simplify the applicability of the procedures. This chapter derives the underlying basic relations of the spectral method for wind buffeting and explains the main important applications of it in order to elucidate part of the theoretical background of computations after the new codes. The stochasticity of the wind processes is addressed, and the analysis of analytical as well as measurement based power spectra is outlined. Short MATLAB codes are added to the Appendix 3 which carry out the computation of a single sided auto-spectrum from a statistically stationary, discrete stochastic process. Two examples are presented.}, language = {en} } @incollection{HendersonWolfScheer2009, author = {Henderson, Colin J. and Wolf, C. Roland and Scheer, Nico}, title = {The use of transgenic animals to study drug metabolism}, series = {Handbook of Drug Metabolism. 2nd Edition}, booktitle = {Handbook of Drug Metabolism. 2nd Edition}, editor = {Woolf, Thomas F.}, publisher = {Informa Healthcare}, address = {New York}, isbn = {978-1-4200-7647-9}, pages = {637 -- 658}, year = {2009}, language = {en} } @incollection{WolfKapelyukhScheeretal.2015, author = {Wolf, C. Roland and Kapelyukh, Yury and Scheer, Nico and Henderson, Colin J.}, title = {Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs}, editor = {Wilson, Alan G. E.}, publisher = {RSC Publ.}, address = {Cambridge}, isbn = {978-1-78262-778-4}, doi = {10.1039/9781782622376-00152}, pages = {152 -- 176}, year = {2015}, abstract = {The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.}, language = {en} }