@inproceedings{BurgazziFioriniDeMagistrisetal.1998, author = {Burgazzi, L. and Fiorini, F. and De Magistris, W. (u.a.) and Lensa, W. von and Staat, Manfred and Altes, J.}, title = {Reliability Assessment of Passive Safety Systems}, series = {Proceedings of the 6th International Conference on Nuclear Engineering : ICONE : May 10 - 14, 1998, San Diego, Calif.}, booktitle = {Proceedings of the 6th International Conference on Nuclear Engineering : ICONE : May 10 - 14, 1998, San Diego, Calif.}, publisher = {American Society of Mechanical Engineers}, address = {New York}, year = {1998}, language = {en} } @article{StaatWoltersBongartsetal.1990, author = {Staat, Manfred and Wolters, J and Bongarts, W. and Hennings, W. (u.a.)}, title = {{\"U}berarbeitete probabilistisch orientierte Sicherheitsanalyse f{\"u}r den HTR-Modul}, series = {Jahrestagung Kerntechnik '90 / Kerntechnische Gesellschaft e.V. ; Deutsches Atomforum e.V}, journal = {Jahrestagung Kerntechnik '90 / Kerntechnische Gesellschaft e.V. ; Deutsches Atomforum e.V}, publisher = {INFORUM}, address = {Bonn}, pages = {143 -- 146}, year = {1990}, language = {de} } @article{SchaeferBoegeShanjiaetal.1994, author = {Sch{\"a}fer, Horst and Boege, P. and Shanjia, Xu and Xinzhang, Wu (u.a.)}, title = {Improved conductivity-measurement of semiconductor epitaxial layers by means of the contactless microwave method}, series = {Conference digest : 10 - 14 January 1994, San Diego, California / International Conference on Millimeter and Submillimeter Waves and Applications / Mohammed N. Afsar, chair/ed.}, journal = {Conference digest : 10 - 14 January 1994, San Diego, California / International Conference on Millimeter and Submillimeter Waves and Applications / Mohammed N. Afsar, chair/ed.}, publisher = {SPIE}, address = {Bellingham, Wash.}, isbn = {0-8194-1558-8}, pages = {649 -- 658}, year = {1994}, language = {en} } @article{SchaeferShaoScholletal.1996, author = {Sch{\"a}fer, Horst and Shao, H. and Scholl, H. and Gersch{\"u}tz, J. (u.a.)}, title = {Shubnikov - de Haas Oscillations of a Two - dimensional Electron Gas in a Modulation - Doped Zn0.80Cd0.20Se/ZnS0.06Se 0.94 Single Quantum Well}, series = {Solid State Communications. 100 (1996), H. 11}, journal = {Solid State Communications. 100 (1996), H. 11}, isbn = {0038-1098}, pages = {739}, year = {1996}, language = {en} } @article{SchaeferSchollWaagetal.1993, author = {Sch{\"a}fer, Horst and Scholl, S. and Waag, A. and Hommel, D. (u.a.)}, title = {Two-dimensional Shubnikov-de Haas oscillations in modulation-doped CdTe/CdMnTe quantum-well structures}, series = {Applied Physics Letters. 62 (1993), H. 23}, journal = {Applied Physics Letters. 62 (1993), H. 23}, pages = {3010 -- 3012}, year = {1993}, language = {en} } @article{SchaeferShenOssauetal.1995, author = {Sch{\"a}fer, Horst and Shen, J. and Ossau, W. and Landwehr, G. (u.a.)}, title = {Optically Detected Cyclotron Resonance (ODCR) in n- and p-type GaAs/AlGaAs Heterostructures}, year = {1995}, language = {en} } @article{SchaeferShaoScholletal.1995, author = {Sch{\"a}fer, Horst and Shao, Hua and Scholl, W. and Hommel, D. (u.a.)}, title = {Quantum Corrections to Magnetotransport in n-ZnSe Grown by MBE}, year = {1995}, language = {en} } @article{SchaeferSchollGerschuetzetal.1994, author = {Sch{\"a}fer, Horst and Scholl, S. and Gersch{\"u}tz, F. and Fischer, A. (u.a.)}, title = {Persistent Photoconductivity in CdTe-based II-VI-Semiconductors}, series = {Solid State Communications. 91 (1994), H. 6}, journal = {Solid State Communications. 91 (1994), H. 6}, isbn = {0038-1098}, pages = {491 -- 495}, year = {1994}, language = {en} } @article{SchaeferShaoGerschuetzetal.1998, author = {Sch{\"a}fer, Horst and Shao, H. and Gersch{\"u}tz, J. and Scholl, S. (u.a.)}, title = {Quantum Interference Effects in Highly Doped n-ZnSe Epitaxy Layers Grown by MBE}, series = {physica status solidi (b). 206 (1998), H. 2}, journal = {physica status solidi (b). 206 (1998), H. 2}, isbn = {0370-1972}, pages = {575 -- 582}, year = {1998}, language = {en} } @article{SchoeningGlueckSchrothetal.1999, author = {Sch{\"o}ning, Michael Josef and Gl{\"u}ck, O. and Schroth, P. and Sch{\"u}tz, S. (u.a.)}, title = {Microelectrodes, capacitors and BioFETs: Novel trends in silicon-based biochemical sensing}, series = {Biocybernetics and Biomedical Engineering. 19 (1999), H. 1}, journal = {Biocybernetics and Biomedical Engineering. 19 (1999), H. 1}, issn = {0208-5216}, pages = {105 -- 126}, year = {1999}, language = {en} } @article{SchaeferRessSpahnetal.1996, author = {Sch{\"a}fer, Horst and Ress, H. R. and Spahn, W. and Ebel, R. (u.a.)}, title = {Hochaufgel{\"o}ste R{\"o}ntgenbeugung zur Untersuchung lateraler Inhomogenit{\"a}ten pseudomorpher ZnSe - Schichten auf GaAs - Substraten}, year = {1996}, language = {de} } @article{SchaeferGerschuetzScholletal.1995, author = {Sch{\"a}fer, Horst and Gersch{\"u}tz, J. and Scholl, S. and Fischer, A. (u.a.)}, title = {Quanten-Hall-Effekt in CdTe/Cd1-X MgX Te Heterostrukturen}, year = {1995}, language = {en} } @article{SchaeferRessSpahnetal.1998, author = {Sch{\"a}fer, Horst and Ress, H. R. and Spahn, W. and Ebel, R. (u.a.)}, title = {Start of misfit relaxation in GaAs-ZnSe heterostructures}, series = {Journal of Crystal Growth. 184-185 (1998)}, journal = {Journal of Crystal Growth. 184-185 (1998)}, isbn = {0022-0248}, pages = {90 -- 94}, year = {1998}, language = {en} } @article{SchoeningTsarouchasSchaubetal.1996, author = {Sch{\"o}ning, Michael Josef and Tsarouchas, D. and Schaub, A. and Beckers, L. (u.a.)}, title = {A highly long-term stable silicon-based pH sensor using pulsed laser deposition technique}, series = {Sensors and Actuators B. 35 (1996), H. 1-3}, journal = {Sensors and Actuators B. 35 (1996), H. 1-3}, isbn = {0925-4005}, pages = {228 -- 233}, year = {1996}, language = {en} } @article{SchoeningSaukeSteffenetal.1995, author = {Sch{\"o}ning, Michael Josef and Sauke, M. and Steffen, A. and Marso, M. (u.a.)}, title = {Ion-sensitive field-effect transistors with ultrathin Langmuir-Blodgett membranes}, series = {Sensors and Actuators B. 27 (1995), H. 1-3}, journal = {Sensors and Actuators B. 27 (1995), H. 1-3}, isbn = {0925-4005}, pages = {325 -- 328}, year = {1995}, language = {en} } @article{SchoeningBrunsHoffmannetal.1993, author = {Sch{\"o}ning, Michael Josef and Bruns, M. and Hoffmann, W. and Hoffmann, B. (u.a.)}, title = {Iodide ion-sensitive field-effect structures}, series = {Sensors and Actuators B. 15 (1993), H. 1-3}, journal = {Sensors and Actuators B. 15 (1993), H. 1-3}, isbn = {0925-4005}, pages = {192 -- 194}, year = {1993}, language = {en} } @article{ArtmannZhouStacheBuettneretal.2002, author = {Artmann, Gerhard and Zhou-Stache, J. and Buettner, R. and Mittermayer, C. [u.a.]}, title = {Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K.}, series = {Medical and Biological Engineering and Computing. 40 (2002), H. 6}, journal = {Medical and Biological Engineering and Computing. 40 (2002), H. 6}, isbn = {0140-0118}, pages = {698 -- 703}, year = {2002}, language = {en} } @article{ArtmannTrzewikMallipattuetal.2001, author = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Mallipattu, S. K. and Delano, F. A. [u.a.]}, title = {Evidence for a second valve system in Lymphatics: Endothelial Microvalves. Trzewik, J{\"u}rgen; Mallipattu, S. K.; Artmann, Gerhard Michael; Delano, F. A.; Schmid-Schonbein, G. W}, series = {The FASEB Journal. 15 (2001)}, journal = {The FASEB Journal. 15 (2001)}, isbn = {1530-6860}, pages = {1711 -- 1717}, year = {2001}, language = {en} } @article{ArtmannBaeumlerVoigtetal.2000, author = {Artmann, Gerhard and B{\"a}umler, H. and Voigt, A. and Mitl{\"o}hner, R. [u.a.]}, title = {Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. B{\"a}umler, H., Artmann, Gerhard Michael; Voigt, A., Mitl{\"o}hner, R., Neu, B., Kiesewetter, H.}, series = {Journal of Microencapsulation. 17 (2000), H. 5}, journal = {Journal of Microencapsulation. 17 (2000), H. 5}, isbn = {1464-5246}, pages = {651 -- 655}, year = {2000}, language = {en} } @article{SchaeferUebbingvonderOstenetal.1996, author = {Sch{\"a}fer, Horst and Uebbing, H. and von der Osten, W. and Hommel, D. (u.a.)}, title = {Exciton and Phonon Quantization in Ultrathin Epitaxial Layers of ZnSe}, series = {23rd International Conference on the Physics of Semiconductors : Berlin, Germany, July 21 - 26, 1996 / ed.: Matthias Scheffler ...}, journal = {23rd International Conference on the Physics of Semiconductors : Berlin, Germany, July 21 - 26, 1996 / ed.: Matthias Scheffler ...}, publisher = {World Scientific}, address = {Singapore [u.a.]}, isbn = {981-02-2777-9}, pages = {365 -- 368}, year = {1996}, language = {en} } @article{ArtmannLiSeipeltetal.1999, author = {Artmann, Gerhard and Li, Anlan and Seipelt, H. and M{\"u}ller, C. [u.a.]}, title = {Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; M{\"u}ller, C.;Shi, Yong de; Artmann, Gerhard Michael}, series = {Pharmacology and Toxicology. 85 (1999)}, journal = {Pharmacology and Toxicology. 85 (1999)}, isbn = {0902-9938}, pages = {206 -- 211}, year = {1999}, language = {en} } @article{ArtmannHovavGoldfarbetal.1999, author = {Artmann, Gerhard and Hovav, T. and Goldfarb, A. and Yedgar, S. [u.a.]}, title = {Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells. Hovav, T., Goldfarb, A.; Artmann, Gerhard Michael, Yedgar, S.; Barstein, G.}, series = {British Journal of Haematology. 106 (1999), H. 1}, journal = {British Journal of Haematology. 106 (1999), H. 1}, isbn = {1365-2141}, pages = {178 -- 181}, year = {1999}, language = {en} } @article{ArtmannKelemenPorstetal.1998, author = {Artmann, Gerhard and Kelemen, Christina and Porst, Dariusz and B{\"u}ldt, G. [u.a.]}, title = {Temperature transitions of protein properties in human red blood cells. Artmann, Gerhard Michael, Kelemen, Christina; Porst, D.; B{\"u}ldt, G.; Chien, S.}, series = {Biophysical Journal. 75 (1998), H. 6}, journal = {Biophysical Journal. 75 (1998), H. 6}, isbn = {1542-0086}, pages = {3179 -- 3183}, year = {1998}, language = {en} } @article{SchaeferWorschechFischeretal.1996, author = {Sch{\"a}fer, Horst and Worschech, L. and Fischer, C. and Schenk, H. (u.a.)}, title = {Linearly Polarized Luminescence associated with Structural Defects in MBE grown ZnSe}, series = {Blue laser and light emitting diodes : [International Symposium on Blue Laser and Light Emitting Diodes (ISBLLED), Chiba, Japan , March 5 - 7, 1996] / ed. by A. Yoshikawa}, journal = {Blue laser and light emitting diodes : [International Symposium on Blue Laser and Light Emitting Diodes (ISBLLED), Chiba, Japan , March 5 - 7, 1996] / ed. by A. Yoshikawa}, publisher = {Ohmsha [u.a.]}, address = {Tokyo}, isbn = {4-274-90096-7}, pages = {421 -- 424}, year = {1996}, language = {en} } @article{ArtmannSchmidSchoenbeinGrebeetal.1988, author = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Grebe, R. and Teitel, P. [u.a.]}, title = {Restoration of Microsieve Filterability of Human Red Cells After Exposure to Hyperosmolarity and Lactazidosis: Effect of Vinpocetine. Schmid-Sch{\"o}nbein, H.; Grebe, R.; Teitel, P.; Artmann, Gerhard Michael, Eschweiler, H.; Schr{\"o}der, Susanne}, series = {Drug Development Research. 14 (1988), H. 3-4}, journal = {Drug Development Research. 14 (1988), H. 3-4}, isbn = {1098-2299}, pages = {205 -- 211}, year = {1988}, language = {en} } @article{ArtmannSchmidSchoenbeinSchroederetal.1988, author = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Schr{\"o}der, Susanne and Grebe, R. [u.a.]}, title = {Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Sch{\"o}nbein, H.; Schr{\"o}der, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P.}, series = {Arzneimittelforschung. 38 (1988), H. 5}, journal = {Arzneimittelforschung. 38 (1988), H. 5}, isbn = {0004-4172}, pages = {710 -- 716}, year = {1988}, language = {en} } @article{SchoeningThustVetteretal.1996, author = {Sch{\"o}ning, Michael Josef and Thust, M. and Vetter, J. and Kordos, P. (u.a.)}, title = {A long-term stable penicillin-sensitive potentiometric biosensor with enzyme immobilized by heterobifunctional crosslinking}, isbn = {0378-4304}, pages = {115 -- 121}, year = {1996}, language = {en} } @article{ArtmannSungHornetal.1997, author = {Artmann, Gerhard and Sung, K.-L. Paul and Horn, Thomas and Whittemore, Darren [u.a.]}, title = {Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Artmann, Gerhard Michael; Sung, K.-L. Paul; Horn, Thomas; Whittemore, Darren; Norwich, Gerald; Chien, Shu}, series = {Biophysical journal. 72 (1997), H. 3}, journal = {Biophysical journal. 72 (1997), H. 3}, isbn = {1542-0086}, pages = {1434 -- 1441}, year = {1997}, language = {en} } @article{SchoeningRonkelCrottetal.1997, author = {Sch{\"o}ning, Michael Josef and Ronkel, F. and Crott, M. and Thust, M. (u.a.)}, title = {Miniaturization of potentiometric sensors using porous silicon microtechnology}, series = {Electrochimica Acta. 42 (1997), H. 22}, journal = {Electrochimica Acta. 42 (1997), H. 22}, isbn = {0013-4686}, pages = {3185 -- 3193}, year = {1997}, language = {en} } @article{ArtmannLiZiemeretal.1996, author = {Artmann, Gerhard and Li, Anlan and Ziemer, J. and Schneider, G. [u.a.]}, title = {A photometric method to analyze induced erythrocyte shape changes. Artmann, Gerhard Michael; Li, Anlan; Ziemer, J.; Schneider, G.; Sahm, U.: ; Ziemer, J.; Schneider, G.; Sahm, U.}, series = {Biorheology. 33 (1996), H. 3}, journal = {Biorheology. 33 (1996), H. 3}, isbn = {0006-355x}, pages = {251 -- 265}, year = {1996}, language = {en} } @article{SchaeferUebbingStolzetal.1995, author = {Sch{\"a}fer, Horst and Uebbing, H. and Stolz, H. and von der Osten, W. (u.a.)}, title = {Resonance Brillouin Scattering from Quantized Exciton-Polaritons in Ultrathin Epitaxial Layers of ZnSe}, series = {Il nuovo Cimento D. 17 (1995)}, journal = {Il nuovo Cimento D. 17 (1995)}, isbn = {0392-6737}, pages = {1753 -- 1757}, year = {1995}, language = {en} } @article{SchaeferSchollGerschuetzetal.1995, author = {Sch{\"a}fer, Horst and Scholl, S. and Gersch{\"u}tz, F. and Fischer, F. (u.a.)}, title = {Persistent Photoconductivity in Halogen-doped Cd1-X ZnX Te, Cd1-X MnX Te and Cd1-X-MgX -Te Layers}, series = {22nd International Conference on the Physics of Semiconductors : Vancouver, Canada, August 15 - 19, 1994 / ed. David J. Lockwood}, journal = {22nd International Conference on the Physics of Semiconductors : Vancouver, Canada, August 15 - 19, 1994 / ed. David J. Lockwood}, publisher = {World Scientific}, address = {Singapore [u.a.]}, isbn = {981-02-2021-9}, pages = {2423 -- 2426}, year = {1995}, language = {en} } @article{ArtmannGrebeHomrighausenetal.1988, author = {Artmann, Gerhard and Grebe, R. and Homrighausen, A. and Wolff, H. and [u.a.],}, title = {Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Sch{\"o}nbein, H.}, series = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, journal = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, publisher = {Karger [u.a.]}, address = {Basel [u.a.]}, pages = {196 -- 200}, year = {1988}, language = {en} } @article{SchoeningHoffmannBrunsetal.1993, author = {Sch{\"o}ning, Michael Josef and Hoffmann, W. and Bruns, M. and Ache, H.J. (u.a.)}, title = {Chemical microsensors and evaporated silver halide layers}, series = {Bulgarian Chemical Communications. 26 (1993), H. 3-4}, journal = {Bulgarian Chemical Communications. 26 (1993), H. 3-4}, isbn = {0324-1130}, pages = {402 -- 410}, year = {1993}, language = {en} } @article{WeberHekmatKananietal.2002, author = {Weber, Hans-Joachim and Hekmat, Khosro and Kanani, Reza and Ahmadpour, R. [u.a.]}, title = {Haben Mobiltelefone einen negativen Einfluss auf moderne Herzschrittmacher? / K. Hekmat, R. Kanani, R. Ahmadpour, G. Lauterbach, M. S{\"u}dkamp, H.-J. Weber, E. R. de Vivie}, series = {Kardiotechnik. 11 (2002), H. 2}, journal = {Kardiotechnik. 11 (2002), H. 2}, isbn = {0941-2670}, pages = {45 -- 47}, year = {2002}, language = {de} } @article{TersteggeWeberHerzogetal.1997, author = {Terstegge, Andreas and Weber, Stefan and Herzog, H. and Reinartz, R. [u.a.]}, title = {The design of an animal PET: flexible geometry for achieving optimal spatial resolution or high sensitivity}, series = {IEEE transactions on medical imaging. 16 (1997), H. 5}, journal = {IEEE transactions on medical imaging. 16 (1997), H. 5}, isbn = {0278-0062}, pages = {684 -- 689}, year = {1997}, language = {en} } @article{TersteggeWeberHerzogetal.1996, author = {Terstegge, Andreas and Weber, Stefan and Herzog, H. and M{\"u}ller-G{\"a}rtner, Hans- W. [u.a.]}, title = {High resolution and better quantification by tube of responsemodelling in 3D PET reconstruction}, series = {Selected papers from the 1996 Nuclear Science Symposium : Marriott Hotel, Anaheim, California, November 3rd - November 9th, 1996}, journal = {Selected papers from the 1996 Nuclear Science Symposium : Marriott Hotel, Anaheim, California, November 3rd - November 9th, 1996}, publisher = {Inst. of Electrical and Electronic Engineers}, address = {New York}, pages = {1603 -- 1607}, year = {1996}, language = {en} } @article{TersteggeFlachskampfFrankeetal.1995, author = {Terstegge, Andreas and Flachskampf, F. A. and Franke, A. and Job, F. P. [u.a.]}, title = {Three-dimensional reconstruction of cardiac structures from transesophageal echocardiography}, series = {American journal of cardiac imaging. 9 (1995), H. 2}, journal = {American journal of cardiac imaging. 9 (1995), H. 2}, isbn = {0887-7971}, pages = {141 -- 147}, year = {1995}, language = {en} } @article{TersteggeWeberHerzogetal.1997, author = {Terstegge, Andreas and Weber, Stefan and Herzog, H. and M{\"u}ller-G{\"a}rtner, Hans- W. [u.a.]}, title = {Entwicklung eines Positronen-Emissions-Tomographen mit hoher Ortsaufl{\"o}sung f{\"u}r Labortiere}, series = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen ; proceedings des Aachener Workshops am 8. und 9. November 1996 / Institut f{\"u}r Medizinische Informatik und Biometrie der RWTH Aachen. Hrsg. von Thomas Lehmann ...}, journal = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen ; proceedings des Aachener Workshops am 8. und 9. November 1996 / Institut f{\"u}r Medizinische Informatik und Biometrie der RWTH Aachen. Hrsg. von Thomas Lehmann ...}, publisher = {Verl. der Augustinus-Buchhandlung}, address = {Aachen}, isbn = {3-86073-519-5}, pages = {267 -- 272}, year = {1997}, language = {de} } @article{WeberSchulteLauterbachetal.1999, author = {Weber, Hans-Joachim and Schulte, A. and Lauterbach, Gerhard and S{\"u}dkamp, Michael [u.a.]}, title = {Studien{\"u}berblick zu transienten Druckexkursionen bei Membranoxygenatoren / A. Schulte, G. Lauterbach, M. S{\"u}dkamp, H.-J. Weber}, series = {Kardiotechnik. 8 (1999), H. 1}, journal = {Kardiotechnik. 8 (1999), H. 1}, isbn = {0941-2670}, pages = {14 -- 16}, year = {1999}, language = {de} } @inproceedings{WeberPorschenDietzeletal.1978, author = {Weber, Hans-Joachim and Porschen, W. and Dietzel, F. and [u.a.],}, title = {In vivo analysis of the influence of combined hyperthermia and gamma irradiation on euoxic and hypoxic tumor cells}, series = {Cancer therapy by hyperthermia and radiation : [proceedings of the 2. International Symposium on Cancer Therapy by Hyperthermia and Radiation, Essen, 2.-4.6.1977]}, booktitle = {Cancer therapy by hyperthermia and radiation : [proceedings of the 2. International Symposium on Cancer Therapy by Hyperthermia and Radiation, Essen, 2.-4.6.1977]}, editor = {Streffer, Christian}, publisher = {Urban and Schwarzenberg}, address = {Baltimore ; Munich [u.a.]}, isbn = {0-8067-1701-7}, pages = {276 -- 277}, year = {1978}, language = {en} } @article{PorschenGartzenGewehretal.1978, author = {Porschen, W. and Gartzen, J. and Gewehr, K. and M{\"u}hlensiepen, H. and Weber, Hans-Joachim and [u.a.],}, title = {In vivo assay of the radiation sensitivity of hypoxic tumour cells : influence of γ-rays, cyclotron neutrons, misonidazole, hyperthermia and mixed modalities}, series = {The British journal of cancer / Supplement}, journal = {The British journal of cancer / Supplement}, number = {3}, publisher = {Lewis}, address = {London}, issn = {0306-9443}, pages = {194 -- 197}, year = {1978}, abstract = {Tumour cell death can be evaluated in the living mouse by externally measuring the rate of loss of tumour-bound DNA tracer. By sequentially labelling the tumour-bearing animals with ¹²⁵IUdR and ¹³¹IUdR 50 h apart, the average tumour cells at the time of the second injection are labelled by ¹²⁵IUdR and the euoxic tumour cells are specifically labelled with ¹³¹IUdR. Tumour treatment at this stage of labelling permits the observation of the reaction of euoxic cells and average tumour cells and finally yields data on hypoxic cells and thus on the oxygen enhancement ratio. This information adds to results from tumour control and growth delay. With this technique effects were analysed of 60-Co γ-rays, cyclotron neutrons (E = 6 MeV), misonidazole (500 mg/kg body wt) and hyperthermia (42°C water-bath), or combinations of these. Misonidazole (15 min before irradiation) altered the oxygen enhancement ratio by a factor of 1·5 for γ-rays and of 1·1 for neutrons; when evaluated from tumour-growth delay and TCD-50 misonidazole gave a dose modifying factor of 1·47 for γ-rays and of 1·2-1·3 for neutrons. Based on percentage tumour regression 100 days after treatment, the enhancement ratio from hyperthermia (after irradiation) was 2·75 for γ-rays (at 10 Gray) and 2·2 for neutrons (at 3·2 Gray). For neutrons combined with misonidazole and hyperthermia the ratio was 2·4. These results demonstrate that effects of neutron irradiation may be modified by electron-affinic substances and/or hyperthermia.}, language = {en} }