@article{BouwmanGuldenHeijdenetal.2013,
  author    = {Bouwman, Peter and Gulden, Hanneke van der and Heijden, Ingrid van der and Drost, Rinske and Klijn, Christiaan N. and Prasetyanti, Pramudita and Pieterse, Mark and Wientjens, Ellen and Seibler, Jost and Hogervorst, Frank B. L. and Jonkers, Jos},
  title     = {A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants},
  series = {Cancer Discovery},
  journal   = {Cancer Discovery},
  number    = {3},
  issn      = {2159-8290},
  doi       = {10.1158/2159-8290.CD-13-0094},
  pages     = {1142 -- 1152},
  year      = {2013},
  language  = {en}
}
@article{EilmannSterckWegneretal.2014,
  author    = {Eilmann, Britta and Sterck, Frank J. and Wegner, L. and de Vries, Sven M. G. and von Arx, G. and Mohren, Godefridus M. J. and den Ouden, Jan and Sass-Klaassen, Ute G. W.},
  title     = {Wood structural differences between northern and southern beech provenances growing at a moderate site},
  series = {Tree Physiology},
  volume    = {34},
  journal   = {Tree Physiology},
  number    = {8},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1758-4469 (Online)},
  doi       = {10.1093/treephys/tpu069},
  pages     = {882 -- 893},
  year      = {2014},
  language  = {en}
}
@incollection{BorchertBremen2014,
  author    = {Borchert, J{\"o}rg and Bremen, Frank},
  title     = {Gesch{\"a}fts- und Organisationsmodelle f{\"u}r ein Strom- und Gas-Portfoliomanagement},
  series = {Optimierte Strom- und Gasbeschaffung in der Energiewirtschaftsbranche},
  booktitle = {Optimierte Strom- und Gasbeschaffung in der Energiewirtschaftsbranche},
  publisher = {KS-Energy-Verl.},
  address   = {Berlin},
  isbn      = {978-3-9813142-9-8},
  pages     = {11 -- 28},
  year      = {2014},
  language  = {de}
}
@article{LuisierLempiaeinenScherbichleretal.2014,
  author    = {Luisier, Rapha{\"e}lle and Lempi{\"a}inen, Harri and Scherbichler, Nina and Braeuning, Albert and Geissler, Miriam and Dubost, Valerie and M{\"u}ller, Arne and Scheer, Nico and Chibout, Salah-Dine and Hara, Hisanori and Picard, Frank and Theil, Diethilde and Couttet, Philippe and Vitobello, Antonio and Grenet, Olivier and Grasl-Kraupp, Bettina and Ellinger-Ziegelbauer, Heidrung and Thomson, John P. and Meehan, Richard R. and Elcombe, Clifford R. and Henderson, Colin J. and Wolf, C. Roland and Schwarz, Michael and Moulin, Pierre and Terranova, Remi and Moggs, Jonathan G.},
  title     = {Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors},
  series = {Toxicological Sciences},
  volume    = {139},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {https://doi.org/10.1093/toxsci/kfu038},
  pages     = {501 -- 511},
  year      = {2014},
  abstract  = {The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.},
  language  = {en}
}
@inproceedings{NeuJanserKhatibietal.2015,
  author    = {Neu, Eugen and Janser, Frank and Khatibi, Akbar A. and Orifici, Adrian C.},
  title     = {Operational modal analysis of a cantilever in a wind tunnel using optical fiber bragg grating sensors},
  series = {6th International Operational Modal Analysis Conference. IOMAC´15. 2015 May 12-14 Gijon - Spain},
  booktitle = {6th International Operational Modal Analysis Conference. IOMAC´15. 2015 May 12-14 Gijon - Spain},
  doi       = {10.13140/RG.2.1.3753.0324},
  pages     = {10 S.},
  year      = {2015},
  language  = {en}
}
@article{DelleHuckBaeckeretal.2015,
  author    = {Delle, Lotta E. and Huck, Christina and B{\"a}cker, Matthias and M{\"u}ller, Frank and Grandthyll, Samuel and Jacobs, Karin and Lilischkis, Rainer and Vu, Xuan T. and Sch{\"o}ning, Michael Josef and Wagner, Patrick and Thoelen, Roland and Weil, Maryam and Ingebrandt, Sven},
  title     = {Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431863},
  pages     = {1327 -- 1334},
  year      = {2015},
  language  = {en}
}
@article{HoevelerJanserBindewaldetal.2015,
  author    = {Hoeveler, Bastian and Janser, Frank and Bindewald, Thorsten and Gebhardt, Andreas},
  title     = {Entwurf, Fertigung und Untersuchung eines Windkanalmodells eines innovativen, senkrechtstartenden Kleinflugzeuges},
  series = {RTejournal - Forum f{\"u}r Rapid Technologie},
  journal   = {RTejournal - Forum f{\"u}r Rapid Technologie},
  number    = {12},
  publisher = {Fachhochschule Aachen},
  address   = {Aachen},
  issn      = {1614-0923},
  url       = {http://nbn-resolving.de/urn:nbn:de:0009-2-42921},
  pages     = {1 -- 5},
  year      = {2015},
  language  = {de}
}
@book{JanserHavermann2015,
  author    = {Janser, Frank and Havermann, Marc},
  title     = {Inkompressible Str{\"o}mungen},
  edition   = {3. Aufl.},
  publisher = {Verlagshaus Mainz GmbH},
  address   = {Aachen},
  isbn      = {978-3-86130-446-3},
  pages     = {VIII, 83 S. : Ill ; Diagramme},
  year      = {2015},
  language  = {de}
}
@inproceedings{NakagawaKallweitMichauxetal.2016,
  author    = {Nakagawa, Masaki and Kallweit, Stephan and Michaux, Frank and Hojo, Teppei},
  title     = {Typical Velocity Fields and Vortical Structures around a Formula One Car, based on Experimental Investigations using Particle Image Velocimetry},
  series = {SAE International Journal of Passenger Cars - Mechanical Systems},
  booktitle = {SAE International Journal of Passenger Cars - Mechanical Systems},
  issn      = {1946-4002},
  doi       = {10.4271/2016-01-1611},
  pages     = {18 S.},
  year      = {2016},
  language  = {en}
}
@article{NeuJanserKhatibietal.2016,
  author    = {Neu, Eugen and Janser, Frank and Khatibi, Akbar A. and Braun, Carsten and Orifici, Adrian C.},
  title     = {Operational Modal Analysis of a wing excited by transonic flow},
  series = {Aerospace Science and Technology},
  volume    = {49},
  journal   = {Aerospace Science and Technology},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1270-9638},
  doi       = {10.1016/j.ast.2015.11.032},
  pages     = {73 -- 79},
  year      = {2016},
  abstract  = {Operational Modal Analysis (OMA) is a promising candidate for flutter testing and Structural Health Monitoring (SHM) of aircraft wings that are passively excited by wind loads. However, no studies have been published where OMA is tested in transonic flows, which is the dominant condition for large civil aircraft and is characterized by complex and unique aerodynamic phenomena. We use data from the HIRENASD large-scale wind tunnel experiment to automatically extract modal parameters from an ambiently excited wing operated in the transonic regime using two OMA methods: Stochastic Subspace Identification (SSI) and Frequency Domain Decomposition (FDD). The system response is evaluated based on accelerometer measurements. The excitation is investigated from surface pressure measurements. The forcing function is shown to be non-white, non-stationary and contaminated by narrow-banded transonic disturbances. All these properties violate fundamental OMA assumptions about the forcing function. Despite this, all physical modes in the investigated frequency range were successfully identified, and in addition transonic pressure waves were identified as physical modes as well. The SSI method showed superior identification capabilities for the investigated case. The investigation shows that complex transonic flows can interfere with OMA. This can make existing approaches for modal tracking unsuitable for their application to aircraft wings operated in the transonic flight regime. Approaches to separate the true physical modes from the transonic disturbances are discussed.},
  language  = {en}
}
@inproceedings{NeuJanserKhatibietal.2016,
  author    = {Neu, Eugen and Janser, Frank and Khatibi, Akbar A. and Orifici, Adrian C.},
  title     = {In-flight vibration-based structural health monitoring of aircraft wings},
  series = {30th Congress of the internatonal council of the aeronautical sciences : 25.-30. September 2016, Daejeon, Korea},
  booktitle = {30th Congress of the internatonal council of the aeronautical sciences : 25.-30. September 2016, Daejeon, Korea},
  pages     = {10 Seiten},
  year      = {2016},
  abstract  = {This work presents a methodology for automated damage-sensitive feature extraction and anomaly detection under multivariate operational variability for in-flight assessment of wings. The method uses a passive excitation approach, i. e. without the need for artificial actuation. The modal system properties (natural frequencies and damping ratios) are used as damage-sensitive features. Special emphasis is placed on the use of Fiber Bragg Grating (FBG) sensing technology and the consideration of Operational and Environmental Variability (OEV). Measurements from a wind tunnel investigation with a composite cantilever equipped with FBG and piezoelectric sensors are used to successfully detect an impact damage. In addition, the feasibility of damage localisation and severity estimation is evaluated based on the coupling found between damageand OEV-induced feature changes.},
  language  = {en}
}
@inproceedings{KleineKallweitMichauxetal.2016,
  author    = {Kleine, Harald and Kallweit, Stephan and Michaux, Frank and Havermann, Marc and Olivier, Herbert},
  title     = {PIV Measurement of Shock Wave Diffraction},
  series = {18th International Symposium on Applications of Laser Techniques to Fluid Mechanics, 2016, Lissabon},
  booktitle = {18th International Symposium on Applications of Laser Techniques to Fluid Mechanics, 2016, Lissabon},
  pages     = {1 -- 14},
  year      = {2016},
  language  = {en}
}
@book{JanserHavermannHoeveleretal.2016,
  author    = {Janser, Frank and Havermann, Marc and Hoeveler, Bastian and Hertz, Cyril},
  title     = {Inkompressible Profil- und Tragfl{\"u}gelaerodynamik},
  series = {Str{\"o}mungslehre und Aerodynamik ; Band 2},
  journal   = {Str{\"o}mungslehre und Aerodynamik ; Band 2},
  edition   = {1. Auflage},
  publisher = {Verlagshaus Mainz GmbH},
  address   = {Aachen},
  isbn      = {978-3-8107-0261-6},
  pages     = {XIII, 208 Seiten},
  year      = {2016},
  language  = {de}
}
@inproceedings{HoevelerJanser2016,
  author    = {Hoeveler, Bastian and Janser, Frank},
  title     = {The aerodynamically optimized design of a fan-in-wing duct},
  series = {Applied Aerodynamics Research Conference 2016, Bristol, GB, Jul 19-21, 2016},
  booktitle = {Applied Aerodynamics Research Conference 2016, Bristol, GB, Jul 19-21, 2016},
  isbn      = {1-85768-371-4},
  pages     = {1 -- 10},
  year      = {2016},
  language  = {en}
}
@article{NeuJanserKhatibietal.2016,
  author    = {Neu, Eugen and Janser, Frank and Khatibi, Akbar A. and Orifici, Adrian C.},
  title     = {Automated modal parameter-based anomaly detection under varying wind excitation},
  series = {Structural Health Monitoring},
  volume    = {15},
  journal   = {Structural Health Monitoring},
  number    = {6},
  publisher = {Sage},
  address   = {London},
  issn      = {1475-9217},
  doi       = {10.1177/1475921716665803},
  pages     = {1 -- 20},
  year      = {2016},
  abstract  = {Wind-induced operational variability is one of the major challenges for structural health monitoring of slender engineering structures like aircraft wings or wind turbine blades. Damage sensitive features often show an even bigger sensitivity to operational variability. In this study a composite cantilever was subjected to multiple mass configurations, velocities and angles of attack in a controlled wind tunnel environment. A small-scale impact damage was introduced to the specimen and the structural response measurements were repeated. The proposed damage detection methodology is based on automated operational modal analysis. A novel baseline preparation procedure is described that reduces the amount of user interaction to the provision of a single consistency threshold. The procedure starts with an indeterminate number of operational modal analysis identifications from a large number of datasets and returns a complete baseline matrix of natural frequencies and damping ratios that is suitable for subsequent anomaly detection. Mahalanobis distance-based anomaly detection is then applied to successfully detect the damage under varying severities of operational variability and with various degrees of knowledge about the present operational conditions. The damage detection capabilities of the proposed methodology were found to be excellent under varying velocities and angles of attack. Damage detection was less successful under joint mass and wind variability but could be significantly improved through the provision of the currently encountered operational conditions.},
  language  = {en}
}
@inproceedings{SchnejiderWisselinkCzarnecki2017,
  author    = {Schnejider, Dominik and Wisselink, Frank and Czarnecki, Christian},
  title     = {Transformation von Wertsch{\"o}pfungsketten durch das Internet der Dinge - Bewertungsrahmen und Fallstudie},
  series = {GI Edition Proceedings Band 275 INFORMATIK 2017},
  booktitle = {GI Edition Proceedings Band 275 INFORMATIK 2017},
  editor    = {Eibl, Maximilian and Gaedke, Martin and Gesellschaft f{\"u}r Informatik e. V. (GI),},
  publisher = {K{\"o}llen},
  address   = {Bonn},
  isbn      = {978-3-88579-669-5},
  issn      = {1617-5468},
  doi       = {10.18420/in2017_208},
  pages     = {2081 -- 2094},
  year      = {2017},
  abstract  = {Momentan finden in vielen Branchen umfassende Ver{\"a}nderungen von M{\"a}rkten und Wertsch{\"o}pfungsketten statt, welche auch als Digitale Transformation bezeichnet werden. In diesem Zusammenhang wird das Internet der Dinge (Internet of Things, IoT) als ein wichtiger technischer Enabler der Ver{\"a}nderungen angesehen. Prim{\"a}re Ziele des IoT sind die Steuerung physischer Gegen-st{\"a}nde aus der Distanz und das Erfassen von Informationen aus dem Umfeld dieser Gegenst{\"a}nde. Welche neuen Gesch{\"a}fts-bzw. Partnermodelle entstehen durch die gemeinsame Nutzung von IoT-Daten und Big-Data-Technologien und welcher qualitative Mehrwert wird dadurch geschaffen? Als Antwort wird in diesem Beitrag ein Bewertungsrahmen zur qualitativen Wertsch{\"o}pfungsanalyse von IoT vorgeschlagen. Anhand dieses Bewertungsrahmens wird ein Anwendungsfall untersucht, der in anonymisierter Form an konkrete Praxisprojekte angelehnt ist. Konkret wird ein Anwendungsfall betrachtet, der eine Abfallwirtschaft 2.0 basierend auf dem Einsatz von IoT vorschl{\"a}gt. Aus den Untersuchungsergebnissen gehen beispielsweise Erkenntnisse hervor, wie Gesch{\"a}ftsmodelle auf Basis eines unentgeltlichen Informationsaustauschs durch IoT gestaltet werden k{\"o}nnen.},
  language  = {de}
}
@inproceedings{ThomeCzarneckiAuthetal.2017,
  author    = {Thom{\´e}, Tristan Eberhard and Czarnecki, Christian and Auth, Gunnar and Bensberg, Frank},
  title     = {Erweiterung des Referenzprozessmodells eTOM um die Anforderungen des deutschen IT-Sicherheitsgesetzes},
  series = {Prozesse, Technologie, Anwendungen, Systeme und Management 2017. Angewandte Forschung in der Wirtschaftsinformatik},
  booktitle = {Prozesse, Technologie, Anwendungen, Systeme und Management 2017. Angewandte Forschung in der Wirtschaftsinformatik},
  editor    = {Barton, Thomas and Herrmann, Frank and Meister, Vera G. and M{\"u}ller, Christian and Seel, Christian},
  publisher = {mana-Buch},
  address   = {Heide},
  isbn      = {978-3-944330-56-3},
  pages     = {51 -- 60},
  year      = {2017},
  abstract  = {Kritische Infrastrukturen sind prim{\"a}re Ziele krimineller Hacker. Der Deutsche Bundestag reagierte darauf am 25. Juli 2015 mit einem Gesetz zur Verbesserung der Sicherheit von ITSystemen, dem IT-Sicherheitsgesetz. Dies verlangt von Betreibern kritischer Infrastrukturen, angemessene Mindeststandards f{\"u}r organisatorische und technische Sicherheit zu implementieren, um den Betrieb und die Verf{\"u}gbarkeit dieser Infrastruktur zu gew{\"a}hrleisten. Telekommunikationsunternehmen sind einerseits von diesem Gesetz in besonderem Maße betroffen und verf{\"u}gen andererseits mit dem Rahmenwerk enhanced Telecom Operations Map (eTOM) {\"u}ber ein international anerkanntes Referenzmodell zur Gestaltung von Gesch{\"a}ftsprozessen in dieser Branche. Da s{\"a}mtliche Telekommunikationsunternehmen in Deutschland verpflichtet sind, das Gesetz innerhalb eines bestimmten Zeitrahmens zu implementieren, pr{\"a}sentiert dieser Beitrag einen Vorschlag zur Erweiterung von eTOM um die relevanten Anforderungen des deutschen IT-Sicherheitsgesetzes.},
  language  = {de}
}
@inproceedings{SchneiderWisselinkCzarnecki2017,
  author    = {Schneider, Dominik and Wisselink, Frank and Czarnecki, Christian},
  title     = {Qualitative Wertsch{\"o}pfungsanalyse von Anwendungsf{\"a}llen des Narrowband Internet of Things},
  series = {Prozesse, Technologie, Anwendungen, Systeme und Management 2017. Angewandte Forschung in der Wirtschaftsinformatik},
  booktitle = {Prozesse, Technologie, Anwendungen, Systeme und Management 2017. Angewandte Forschung in der Wirtschaftsinformatik},
  editor    = {Barton, Thomas and Herrmann, Frank and Meister, Vera G. and M{\"u}ller, Christian and Seel, Christian},
  publisher = {mana-Buch},
  address   = {Heide},
  isbn      = {978-3-944330-56-3},
  pages     = {184 -- 193},
  year      = {2017},
  abstract  = {Prim{\"a}re Ziele des Internets der Dinge sind die Steuerung physischer Gegenst{\"a}nde aus der Distanz und das Erfassen von Informationen aus dem Umfeld dieser Gegenst{\"a}nde. Dazu werden Hardwarekomponenten in Gegenst{\"a}nde des t{\"a}glichen Lebens und die Umwelt integriert. Mithilfe von Informations- und Kommunikationstechnologien entsteht hieraus das Internet der Dinge (Internet of Things, IoT). Vor einem Jahr wurde mit Narrowband Internet of Things (NB-IoT) eine Technologie die es erm{\"o}glicht, Hardwarekomponenten energieeffizient und unmittelbar {\"u}ber das Mobilfunknetz zu vernetzen. Gegenst{\"a}nde werden dadurch {\"u}ber große Reichweiten eigenst{\"a}ndig kommunikationsf{\"a}hig. Das IoT steht mit NB-IoT vor einem gestiegenen Nutzenpotenzial, da eine zunehmende Anzahl miteinander verbundener Gegenst{\"a}nde und der Austausch gr{\"o}ßerer Datenmengen realisierbar sind. Damit sind aus wirtschaftlicher Sicht neue, innovative Anwendungsf{\"a}lle des IoT m{\"o}glich, die auch bereits in der Praxis diskutiert werden. In diesem Beitrag wird anhand eines konkreten Anwendungsfalls untersucht, welche neuen Gesch{\"a}fts- bzw. Partnermodelle durch die gemeinsame Nutzung von NB-IoT-Daten und Big Data-Technologien entstehen und welcher qualitative Mehrwert f{\"u}r die an einem Anwendungsfall beteiligten Stakeholder geschaffen wird. Dazu wird - einem konstruktionsorientierten Forschungsansatz folgend - ein Bewertungsrahmen zur qualitativen Wertsch{\"o}pfungsanalyse von NB-IoT entwickelt, der u.a. auf der Schablone nach Cockburn und dem Business Model Canvas basiert. Anhand dieses Bewertungsrahmens wird ein Anwendungsfall untersucht, der in anonymisierter Form an konkrete Praxisprojekte angelehnt ist. Konkret wird ein Anwendungsfall betrachtet, der einen Fahrradverleih 2.0 basierend auf dem Einsatz von NB-IoT vorschl{\"a}gt. Aus den Untersuchungsergebnissen gehen beispielsweise Erkenntnisse hervor, wie Gesch{\"a}ftsmodelle auf},
  language  = {de}
}
@article{NeuJanserKhatibietal.2017,
  author    = {Neu, Eugen and Janser, Frank and Khatibi, Akbar A. and Orifici, Adrian C.},
  title     = {Fully Automated Operational Modal Analysis using multi-stage clustering},
  series = {Mechanical Systems and Signal Processing},
  volume    = {Vol. 84, Part A},
  journal   = {Mechanical Systems and Signal Processing},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0888-3270},
  doi       = {10.1016/j.ymssp.2016.07.031},
  pages     = {308 -- 323},
  year      = {2017},
  language  = {en}
}
@inproceedings{GaldiHartungDugelay2017,
  author    = {Galdi, Chiara and Hartung, Frank and Dugelay, Jean-Luc},
  title     = {Videos versus still images: Asymmetric sensor pattern noise comparison on mobile phones},
  series = {Electronic Imaging},
  booktitle = {Electronic Imaging},
  publisher = {Society for Imaging Science and Technology},
  address   = {Springfield, Virginia},
  issn      = {2470-1173},
  doi       = {10.2352/ISSN.2470-1173.2017.7.MWSF-331},
  pages     = {100 -- 103},
  year      = {2017},
  abstract  = {Nowadays, the most employed devices for recoding videos or capturing images are undoubtedly the smartphones. Our work investigates the application of source camera identification on mobile phones. We present a dataset entirely collected by mobile phones. The dataset contains both still images and videos collected by 67 different smartphones. Part of the images consists in photos of uniform backgrounds, especially collected for the computation of the RSPN. Identifying the source camera given a video is particularly challenging due to the strong video compression. The experiments reported in this paper, show the large variation in performance when testing an highly accurate technique on still images and videos.},
  language  = {en}
}