@article{SchmidtForkmannSinkeetal.2016,
  author    = {Schmidt, K. and Forkmann, K. and Sinke, C. and Gratz, M. and Bitz, Andreas and Bingel, U.},
  title     = {The differential effect of trigeminal vs. peripheral pain stimulation on visual processing and memory encoding is influenced by pain-related fear},
  series = {NeuroImage},
  volume    = {134},
  journal   = {NeuroImage},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1053-8119},
  doi       = {10.1016/j.neuroimage.2016.03.026},
  pages     = {386 -- 395},
  year      = {2016},
  abstract  = {Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memory encoding. Cerebral activity was measured in 23 healthy subjects performing a visual categorization task that was immediately followed by a surprise recognition task. During the categorization task subjects received concomitant noxious electrical stimulation on the forehead or hand. Our data show that fear ratings were significantly higher for trigeminal pain. Categorization and recognition performance did not differ between pictures that were presented with trigeminal and peripheral pain. However, object categorization in the presence of trigeminal pain was associated with stronger activity in task-relevant visual areas (lateral occipital complex, LOC), memory encoding areas (hippocampus and parahippocampus) and areas implicated in emotional processing (amygdala) compared to peripheral pain. Further, individual differences in neural activation between the trigeminal and the peripheral condition were positively related to differences in fear ratings between both conditions. Functional connectivity between amygdala and LOC was increased during trigeminal compared to peripheral painful stimulation. Fear-driven compensatory resource activation seems to be enhanced for trigeminal stimuli, presumably due to their exceptional biological relevance.},
  language  = {en}
}
@article{BankOrzadaSmitsetal.2015,
  author    = {Bank, Bart L. van de and Orzada, Stephan and Smits, Frits and Lagemaat, Miriam W. and Rodgers, Christopher T. and Bitz, Andreas and Scheenen, Tom W. J.},
  title     = {Optimized (31) P MRS in the human brain at 7 T with a dedicated RF coil setup},
  series = {NMR in Biomedicine},
  volume    = {28},
  journal   = {NMR in Biomedicine},
  number    = {11},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1099-1492},
  doi       = {10.1002/nbm.3422},
  pages     = {1570 -- 1578},
  year      = {2015},
  language  = {en}
}
@article{NoureddineBitzLaddetal.2015,
  author    = {Noureddine, Yacine and Bitz, Andreas and Ladd, Mark E. and Th{\"u}rling, Markus and Ladd, Susanne C. and Schaefers, Gregor and Kraff, Oliver},
  title     = {Experience with magnetic resonance imaging of human subjects with passive implants and tattoos at 7 T: a retrospective study},
  series = {Magnetic Resonance Materials in Physics, Biology and Medicine},
  volume    = {28},
  journal   = {Magnetic Resonance Materials in Physics, Biology and Medicine},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1352-8661},
  doi       = {10.1007/s10334-015-0499-y},
  pages     = {577 -- 590},
  year      = {2015},
  language  = {en}
}
@article{LagemaatBreukelsVosetal.2016,
  author    = {Lagemaat, Miriam W. and Breukels, Vincent and Vos, Eline K. and B., Adam and Uden, Mark J. van and Orzada, Stephan and Bitz, Andreas and Maas, Marnix C. and Scheenen, Tom W. J.},
  title     = {¹H MR spectroscopic imaging of the prostate at 7T using spectral-spatial pulses},
  series = {Magnetic Resonance in Medicine},
  volume    = {75},
  journal   = {Magnetic Resonance in Medicine},
  number    = {3},
  publisher = {International Society for Magnetic Resonance in Medicine},
  issn      = {1522-2594},
  doi       = {10.1002/mrm.25569},
  pages     = {933 -- 945},
  year      = {2016},
  abstract  = {Purpose To assess the feasibility of prostate ¹H MR spectroscopic imaging (MRSI) using low-power spectral-spatial (SPSP) pulses at 7T, exploiting accurate spectral selection and spatial selectivity simultaneously. Methods A double spin-echo sequence was equipped with SPSP refocusing pulses with a spectral selectivity of 1 ppm. Three-dimensional prostate ¹H-MRSI at 7T was performed with the SPSP-MRSI sequence using an 8-channel transmit array coil and an endorectal receive coil in three patients with prostate cancer and in one healthy subject. No additional water or lipid suppression pulses were used. Results Prostate ¹H-MRSI could be obtained well within specific absorption rate (SAR) limits in a clinically feasible time (10 min). Next to the common citrate signals, the prostate spectra exhibited high spermine signals concealing creatine and sometimes also choline. Residual lipid signals were observed at the edges of the prostate because of limitations in spectral and spatial selectivity. Conclusion It is possible to perform prostate ¹H-MRSI at 7T with a SPSP-MRSI sequence while using separate transmit and receive coils. This low-SAR MRSI concept provides the opportunity to increase spatial resolution of MRSI within reasonable scan times.},
  language  = {en}
}
@article{VosLagemaatBarentszetal.2014,
  author    = {Vos, E. K. and Lagemaat, M. W. and Barentsz, J. O. and F{\"u}tterer, J. J. and Zamecnik, P. and Roozen, H. and Orzada, S. and Bitz, Andreas and Maas, M. C. and Scheenen, T. W. J.},
  title     = {Image quality and cancer visibility of T2-weighted Magnetic Resonance Imaging of the prostate at 7 Tesla},
  series = {European Radiology},
  volume    = {24},
  journal   = {European Radiology},
  number    = {8},
  publisher = {Springer},
  address   = {Cham},
  issn      = {1432-1084},
  doi       = {10.1007/s00330-014-3234-6},
  pages     = {1950 -- 1958},
  year      = {2014},
  abstract  = {Objectives To assess the image quality of T2-weighted (T2w) magnetic resonance imaging of the prostate and the visibility of prostate cancer at 7 Tesla (T). Materials \& methods Seventeen prostate cancer patients underwent T2w imaging at 7T with only an external transmit/receive array coil. Three radiologists independently scored images for image quality, visibility of anatomical structures, and presence of artefacts. Krippendorff's alpha and weighted kappa statistics were used to assess inter-observer agreement. Visibility of prostate cancer lesions was assessed by directly linking the T2w images to the confirmed location of prostate cancer on histopathology. Results T2w imaging at 7T was achievable with 'satisfactory' (3/5) to 'good' (4/5) quality. Visibility of anatomical structures was predominantly scored as 'satisfactory' (3/5) and 'good' (4/5). If artefacts were present, they were mostly motion artefacts and, to a lesser extent, aliasing artefacts and noise. Krippendorff's analysis revealed an α = 0.44 between three readers for the overall image quality scores. Clinically significant cancer lesions in both peripheral zone and transition zone were visible at 7T. Conclusion T2w imaging with satisfactory to good quality can be routinely acquired, and cancer lesions were visible in patients with prostate cancer at 7T using only an external transmit/receive body array coil.},
  language  = {en}
}
@article{LagemaatMaasVosetal.2015,
  author    = {Lagemaat, Miriam W. and Maas, Marnix C. and Vos, Eline K. and Bitz, Andreas and Orzada, Stephan and Weiland, Elisabeth and Uden, Mark J. van and Kobus, Thiele and Heerschap, Arend and Scheenen, Tom W. J.},
  title     = {(31) P MR spectroscopic imaging of the human prostate at 7 T: T1 relaxation times, Nuclear Overhauser Effect, and spectral characterization},
  series = {Magnetic Resonance in Medicine},
  volume    = {73},
  journal   = {Magnetic Resonance in Medicine},
  number    = {3},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1522-2594},
  doi       = {10.1002/mrm.25209},
  pages     = {909 -- 920},
  year      = {2015},
  language  = {en}
}
@article{LagemaatVosMaasetal.2014,
  author    = {Lagemaat, Miriam W. and Vos, Eline K. and Maas, Marnix C. and Bitz, Andreas and Orzada, Stephan and Uden, Mark J. van and Kobus, Thiele and Heerschap, Arend and Scheenen, Tom W. J.},
  title     = {Phosphorus magnetic resonance spectroscopic imaging at 7 T in patients with prostate cancer},
  series = {Investigative Radiology},
  volume    = {49},
  journal   = {Investigative Radiology},
  number    = {5},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia, Pa.},
  issn      = {1536-0210},
  doi       = {10.1097/RLI.0000000000000012},
  pages     = {363 -- 372},
  year      = {2014},
  abstract  = {Objectives The aim of this study was to identify characteristics of phosphorus (³¹P) spectra of the human prostate and to investigate changes of individual phospholipid metabolites in prostate cancer through in vivo ³¹P magnetic resonance spectroscopic imaging (MRSI) at 7 T. Materials and Methods In this institutional review board-approved study, 15 patients with biopsy-proven prostate cancer underwent T₂-weighted magnetic resonance imaging and 3-dimensional ³¹P MRSI at 7 T. Voxels were selected at the tumor location, in normal-appearing peripheral zone tissue, normal-appearing transition zone tissue, and in the base of the prostate close to the seminal vesicles. Phosphorus metabolite ratios were determined and compared between tissue types. Results Signals of phosphoethanolamine (PE) and phosphocholine (PC) were present and well resolved in most ³¹P spectra in the prostate. Glycerophosphocholine signals were observable in 43\% of the voxels in malignant tissue, but in only 10\% of the voxels in normal-appearing tissue away from the seminal vesicles. In many spectra, independent of tissue type, 2 peaks resonated in the chemical shift range of inorganic phosphate, possibly representing 2 separate pH compartments. The PC/PE ratio in the seminal vesicles was highly elevated compared with the prostate in 5 patients. A considerable overlap of ³¹P metabolite ratios was found between prostate cancer and normal-appearing prostate tissue, preventing direct discrimination of these tissues. The only 2 patients with high Gleason scores tumors (≥4+5) presented with high PC and glycerophosphocholine levels in their cancer lesions. Conclusions Phosphorus MRSI at 7 T shows distinct features of phospholipid metabolites in the prostate gland and its surrounding structures. In this exploratory study, no differences in ³¹P metabolite ratios were observed between prostate cancer and normal-appearing prostate tissue possibly because of the partial volume effects of small tumor foci in large MRSI voxels.},
  language  = {en}
}
@article{FiedlerLaddBitz2017,
  author    = {Fiedler, Thomas M. and Ladd, Mark E. and Bitz, Andreas},
  title     = {SAR Simulations \& Safety},
  series = {NeuroImage},
  journal   = {NeuroImage},
  number    = {Epub ahead of print},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1053-8119},
  doi       = {10.1016/j.neuroimage.2017.03.035},
  year      = {2017},
  language  = {en}
}
@article{NoureddineKraffLaddetal.2017,
  author    = {Noureddine, Yacine and Kraff, Oliver and Ladd, Mark E. and Wrede, Karsten H. and Chen, Bixia and Quick, Harald H. and Schaefers, Gregor and Bitz, Andreas},
  title     = {In vitro and in silico assessment of RF-induced heating around intracranial aneurysm clips at 7 Tesla},
  series = {Magnetic Resonance in Medicine},
  journal   = {Magnetic Resonance in Medicine},
  number    = {Early view},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1522-2594},
  doi       = {10.1002/mrm.26650},
  pages     = {14 Seiten},
  year      = {2017},
  language  = {en}
}
@article{FiedlerLaddBitz2017,
  author    = {Fiedler, Thomas M. and Ladd, Mark E. and Bitz, Andreas},
  title     = {RF safety assessment of a bilateral four-channel transmit/receive 7 Tesla breast coil: SAR versus temperature limits},
  series = {Medical Physics},
  volume    = {44},
  journal   = {Medical Physics},
  number    = {1},
  doi       = {10.1002/mp.12034},
  pages     = {143 -- 157},
  year      = {2017},
  language  = {en}
}