@inproceedings{BrandesEppleGligorevicetal.2009, author = {Brandes, Sinja and Epple, U. and Gligorevic, Snjezana and Schnell, Michael and Haindl, Bernhard and Sajatovic, Miodrag}, title = {Physical layer specification of the L-band Digital Aeronautical Communications System (L-DACS1)}, series = {Integrated Communications, Navigation and Surveillance Conference : ICNS '09 : 13 - 15 May 2009, Arlington, Va.}, booktitle = {Integrated Communications, Navigation and Surveillance Conference : ICNS '09 : 13 - 15 May 2009, Arlington, Va.}, organization = {Institute of Electrical and Electronics Engineers}, isbn = {978-1-4244-4733-6 ; 978-1-4244-4734-3}, pages = {1 -- 12}, year = {2009}, language = {en} } @inproceedings{EppleBrandesGligorevicetal.2009, author = {Epple, U. and Brandes, Sinja and Gligorevic, Snjezana and Schnell, Michael}, title = {Receiver optimization for L-DACS1}, series = {IEEE/AIAA 28th Digital Avionics Systems Conference : 23-29 Oct. 2009 : Orlando, Fla.}, booktitle = {IEEE/AIAA 28th Digital Avionics Systems Conference : 23-29 Oct. 2009 : Orlando, Fla.}, organization = {Institute of Electrical and Electronics Engineers}, isbn = {978-1-4244-4078-8}, pages = {4B1-1 -- 4B1-12}, year = {2009}, language = {en} } @article{GossmannFrotscherLinderetal.2016, author = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells}, series = {Cellular physiology and biochemistry}, volume = {38}, journal = {Cellular physiology and biochemistry}, number = {3}, publisher = {Karger}, address = {Basel}, issn = {1421-9778 (Online)}, doi = {10.1159/000443124}, pages = {1182 -- 1198}, year = {2016}, abstract = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.}, language = {en} }