@inproceedings{SchmiegelKochDittmeretal.2010, author = {Schmiegel, A. and Koch, K. and Dittmer, M. and Braun, M. and Landau, M. and Dick, C. and Bragard, Michael and [u.a.],}, title = {Das Sol-ion System : ein System zur Optimierung des Eigenverbrauchs von PV-Strom}, series = {Photovoltaische Solarenergie : 25. Symposium ; 03. - 05. M{\"a}rz 2010, Kloster Banz, Bad Staffelstein. - (Wissen f{\"u}r Profis)}, booktitle = {Photovoltaische Solarenergie : 25. Symposium ; 03. - 05. M{\"a}rz 2010, Kloster Banz, Bad Staffelstein. - (Wissen f{\"u}r Profis)}, publisher = {OTTI, Ostbayerisches Technologie-Transfer-Inst.}, address = {Regensburg}, isbn = {978-3-941785-23-6}, pages = {354 -- 359}, year = {2010}, language = {de} } @article{JordanKruegerWillmesetal.2011, author = {Jordan, Sabine D. and Kr{\"u}ger, Markus and Willmes, Diana M. and Redemann, Nora and Wunderlich, F. Thomas and Br{\"o}nneke, Hella S. and Merkwirth, Carsten and Kashkar, Hamid and Olkkonen, Vesa M. and B{\"o}ttger, Thomas and Braun, Thomas and Seibler, Jost and Br{\"u}ning, Jens C.}, title = {Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism}, series = {Nature Cell Biology}, volume = {13}, journal = {Nature Cell Biology}, number = {4}, publisher = {Nature}, address = {New York}, issn = {1465-7392}, doi = {10.1038/ncb2211}, pages = {434 -- 446}, year = {2011}, abstract = {The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143-145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143-ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.}, language = {en} } @incollection{BraunBouckeHankeetal.2003, author = {Braun, Carsten and Boucke, Alexander and Hanke, M. and Karavas, Alexandros and Ballmann, Josef}, title = {Prediction of the model deformation of a high speed transport aircraft type wing by direct aeroelastic simulation}, series = {High performance computing in science and engineering '03. Transactions of the High Performance Computing Center Stuttgart (HLRS) 2003 / Eds.: Egon Krause ...}, booktitle = {High performance computing in science and engineering '03. Transactions of the High Performance Computing Center Stuttgart (HLRS) 2003 / Eds.: Egon Krause ...}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-40850-5}, pages = {331 -- 342}, year = {2003}, language = {de} } @incollection{BrittenBraunHesseetal.2003, author = {Britten, G. and Braun, Carsten and Hesse, M. and Ballmann, Josef}, title = {Computational aeroelasticity with reduced structural models}, series = {Flow modulation and fluid-structure interaction at airplane wings : research results of the Collaborative Research Center SFB 401 at RWTH Aachen, University of Technology, Aachen, Germany / Josef Ballmann (Ed.) Notes on numerical fluid mechanics and multidisciplinary design. Vol. 84}, booktitle = {Flow modulation and fluid-structure interaction at airplane wings : research results of the Collaborative Research Center SFB 401 at RWTH Aachen, University of Technology, Aachen, Germany / Josef Ballmann (Ed.) Notes on numerical fluid mechanics and multidisciplinary design. Vol. 84}, publisher = {Springer}, address = {Berlin}, isbn = {3-540-40209-8}, pages = {275 -- 299}, year = {2003}, language = {en} } @article{GoettenFingerHavermannetal.2021, author = {G{\"o}tten, Falk and Finger, Felix and Havermann, Marc and Braun, Carsten and Marino, M. and Bil, C.}, title = {Full configuration drag estimation of short-to-medium range fixed-wing UAVs and its impact on initial sizing optimization}, series = {CEAS Aeronautical Journal}, volume = {12}, journal = {CEAS Aeronautical Journal}, publisher = {Springer}, address = {Berlin}, issn = {1869-5590 (Online)}, doi = {10.1007/s13272-021-00522-w}, pages = {589 -- 603}, year = {2021}, abstract = {The paper presents the derivation of a new equivalent skin friction coefficient for estimating the parasitic drag of short-to-medium range fixed-wing unmanned aircraft. The new coefficient is derived from an aerodynamic analysis of ten different unmanned aircraft used for surveillance, reconnaissance, and search and rescue missions. The aircraft is simulated using a validated unsteady Reynolds-averaged Navier Stokes approach. The UAV's parasitic drag is significantly influenced by the presence of miscellaneous components like fixed landing gears or electro-optical sensor turrets. These components are responsible for almost half of an unmanned aircraft's total parasitic drag. The new equivalent skin friction coefficient accounts for these effects and is significantly higher compared to other aircraft categories. It is used to initially size an unmanned aircraft for a typical reconnaissance mission. The improved parasitic drag estimation yields a much heavier unmanned aircraft when compared to the sizing results using available drag data of manned aircraft.}, language = {en} }