@article{RoeschKratzHeringetal.2016,
  author    = {R{\"o}sch, C. and Kratz, F. and Hering, T. and Trautmann, S. and Umanskaya, N. and Tippk{\"o}tter, Nils and M{\"u}ller-Renno, C.M. and Ulber, R. and Hannig, M. and Ziegler, C.},
  title     = {Albumin-lysozyme interactions: cooperative adsorption on titanium and enzymatic activity},
  series = {Colloids and Surfaces B: Biointerfaces},
  volume    = {149},
  journal   = {Colloids and Surfaces B: Biointerfaces},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.colsurfb.2016.09.048},
  pages     = {115 -- 121},
  year      = {2016},
  abstract  = {The interplay of albumin (BSA) and lysozyme (LYZ) adsorbed simultaneously on titanium was analyzed by gel electrophoresis and BCA assay. It was found that BSA and lysozyme adsorb cooperatively. Additionally, the isoelectric point of the respective protein influences the adsorption. Also, the enzymatic activity of lysozyme and amylase (AMY) in mixtures with BSA was considered with respect to a possible influence of protein-protein interaction on enzyme activity. Indeed, an increase of lysozyme activity in the presence of BSA could be observed. In contrast, BSA does not influence the activity of amylase.},
  language  = {en}
}
@article{SchwarzerMuellerMertes2004,
  author    = {Schwarzer, Klemens and M{\"u}ller, C. and Mertes, C.},
  title     = {Solar thermal desalination systems with multi-layer heat recovery / C. M{\"u}ller ; K. Schwarzer ; C. Mertes ...},
  series = {Proceedings / organised by: ISES Europe ... [Ed.: Deutsche Gesellschaft f{\"u}r Sonnenenergie e.V. - DGS, Munich ; PSE GmbH - Forschung Entwicklung Marketing, Freiburg]. - Vol 1},
  journal   = {Proceedings / organised by: ISES Europe ... [Ed.: Deutsche Gesellschaft f{\"u}r Sonnenenergie e.V. - DGS, Munich ; PSE GmbH - Forschung Entwicklung Marketing, Freiburg]. - Vol 1},
  publisher = {PSE},
  address   = {Freiburg [Breisgau]},
  isbn      = {3-9809656-1-9},
  pages     = {1-647-1-652},
  year      = {2004},
  language  = {en}
}
@article{SimonisRugeMuellerVeggianetal.2003,
  author    = {Simonis, A. and Ruge, C. and M{\"u}ller-Veggian, Mattea and L{\"u}th, H. and Sch{\"o}ning, Michael Josef},
  title     = {A long-term stable macroporoustype EIS structure for electrochemical sensor applications},
  series = {Sensors and Actuators B. 91 (2003), H. 1-3},
  journal   = {Sensors and Actuators B. 91 (2003), H. 1-3},
  isbn      = {0925-4005},
  pages     = {21 -- 25},
  year      = {2003},
  language  = {en}
}
@article{ArtmannLiSeipeltetal.1999,
  author    = {Artmann, Gerhard and Li, Anlan and Seipelt, H. and M{\"u}ller, C. [u.a.]},
  title     = {Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; M{\"u}ller, C.;Shi, Yong de; Artmann, Gerhard Michael},
  series = {Pharmacology and Toxicology. 85 (1999)},
  journal   = {Pharmacology and Toxicology. 85 (1999)},
  isbn      = {0902-9938},
  pages     = {206 -- 211},
  year      = {1999},
  language  = {en}
}
@article{MuellerVeggianGonoLiederetal.1975,
  author    = {M{\"u}ller-Veggian, Mattea and Gono, Y. and Lieder, R. M. and Mayer-B{\"o}ricke, C.},
  title     = {Suche nach isomeren Zust{\"a}nden in ¹³⁶ Ce},
  series = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. (VI) 10 (1975)},
  journal   = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. (VI) 10 (1975)},
  publisher = {Physik-Verlag},
  address   = {Weinheim},
  pages     = {781},
  year      = {1975},
  language  = {de}
}
@article{GonoLiederMayerBoerickeetal.1976,
  author    = {Gono, Y. and Lieder, R. M. and Mayer-B{\"o}ricke, C. and M{\"u}ller-Veggian, Mattea},
  title     = {High spin states and isomers in ¹⁸⁹,¹⁹¹,¹⁹³ Au},
  series = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)},
  journal   = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)},
  pages     = {952},
  year      = {1976},
  language  = {en}
}
@article{MuellerVeggianGonoLiederetal.1976,
  author    = {M{\"u}ller-Veggian, Mattea and Gono, Y. and Lieder, R. M. and Mayer-B{\"o}ricke, C.},
  title     = {Investigation of high spin states and isomers in ¹³⁶,¹³⁷ Ce},
  series = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)},
  journal   = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)},
  pages     = {911 -- 912},
  year      = {1976},
  language  = {en}
}
@article{MuellerVeggianGonoLiederetal.1976,
  author    = {M{\"u}ller-Veggian, Mattea and Gono, Y. and Lieder, R. M. and Mayer-B{\"o}ricke, C.},
  title     = {Study of high spin states in ¹⁹⁵,¹⁹⁷ Tl},
  series = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)},
  journal   = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)},
  pages     = {952},
  year      = {1976},
  language  = {en}
}
@article{MuellerVeggianJannsensMasrietal.1976,
  author    = {M{\"u}ller-Veggian, Mattea and Jannsens, R. and Masri, Y. El. and Michel, C.},
  title     = {Untersuchung der Hochspinzust{\"a}nde in ¹⁷⁸,¹⁸⁰ Os},
  series = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)},
  journal   = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976)},
  pages     = {950},
  year      = {1976},
  language  = {en}
}
@article{SchwarzerMuellerWagner2000,
  author    = {Schwarzer, Klemens and M{\"u}ller, C. and Wagner, A.},
  title     = {Entwicklung und Bau einer solaren Geb{\"a}udeheizung im Altiplano/Argentinien / C. M{\"u}ller ; K. Schwarzer ; A. Wagner ...},
  series = {Sonne - die Energie des 21. Jahrhunderts : Kurzfassungen; 5. - 7. Juli 2000 Freiburg; inklusive 11. Jahrestagung Forschungsverbund Sonnenenergie / 12. Internationales Sonnenforum. [Hrsg.: Deutsche Gesellschaft f{\"u}r Sonnenenergie e.V., DGS. Red.: Joachim Berner; Forschungsverbund Sonnenenergie]},
  journal   = {Sonne - die Energie des 21. Jahrhunderts : Kurzfassungen; 5. - 7. Juli 2000 Freiburg; inklusive 11. Jahrestagung Forschungsverbund Sonnenenergie / 12. Internationales Sonnenforum. [Hrsg.: Deutsche Gesellschaft f{\"u}r Sonnenenergie e.V., DGS. Red.: Joachim Berner; Forschungsverbund Sonnenenergie]},
  publisher = {Solar Promotion},
  address   = {M{\"u}nchen},
  isbn      = {3-934349-07-2},
  pages     = {269 -- 272},
  year      = {2000},
  language  = {de}
}
@article{SchwarzerMuellerKleineHering2004,
  author    = {Schwarzer, Klemens and M{\"u}ller, C. and Kleine-Hering, H.},
  title     = {Simple solar systems for heating, hot water and cooking in high altitude regions with high solar radiation / C. M{\"u}ller ; K. Schwarzer ; H. Kleine-Hering},
  series = {Proceedings / organised by: ISES Europe ... [Ed.: Deutsche Gesellschaft f{\"u}r Sonnenenergie e.V. - DGS, Munich ; PSE GmbH - Forschung Entwicklung Marketing, Freiburg]. - Vol 1},
  journal   = {Proceedings / organised by: ISES Europe ... [Ed.: Deutsche Gesellschaft f{\"u}r Sonnenenergie e.V. - DGS, Munich ; PSE GmbH - Forschung Entwicklung Marketing, Freiburg]. - Vol 1},
  publisher = {PSE},
  address   = {Freiburg [Breisgau]},
  isbn      = {3-9809656-1-9},
  pages     = {1-653-1-658},
  year      = {2004},
  language  = {en}
}
@book{SchwarzerMueller2003,
  author    = {Schwarzer, Klemens and M{\"u}ller, C.},
  title     = {Entwicklung und Optimierung einer Geb{\"a}udeheizung f{\"u}r den Einsatz in Hochgebirgsregionen mit hoher solarer Einstrahlung : Abschlussbericht},
  publisher = {Solar-Institut Juelich, Fachhochschule Aachen},
  address   = {J{\"u}lich},
  pages     = {118 S.},
  year      = {2003},
  language  = {de}
}
@article{SchwarzerMuellerVieiradaSilva2004,
  author    = {Schwarzer, Klemens and M{\"u}ller, C. and Vieira da Silva, E.},
  title     = {Solare Meerwasser-Entsalzungsanlagen mit mehrstufiger W{\"a}rmer{\"u}ckgewinnung / C. M{\"u}ller ; K. Schwarzer ; E. Vieira da Silva ...},
  series = {14. Symposium Thermische Solarenergie : 12. bis 14. Mai, 2004, Kloster Banz / [Veranst.: OTTI Energie-Kolleg]},
  journal   = {14. Symposium Thermische Solarenergie : 12. bis 14. Mai, 2004, Kloster Banz / [Veranst.: OTTI Energie-Kolleg]},
  publisher = {Ostbayerisches Technologie-Transfer-Institut},
  address   = {Regensburg},
  isbn      = {3-934681-33-6},
  pages     = {154 -- 159},
  year      = {2004},
  language  = {en}
}
@article{BansalMuellerVieiraetal.2000,
  author    = {Bansal, N. K. and M{\"u}ller, C. and Vieira, M. E. and Faber, Christian and Schwarzer, Klemens},
  title     = {Thermal performance of a rock bed storage system},
  series = {Proceedings : University of Stuttgart, Germany, August 28th until September 1st, 2000 / Terrastock 2000, 8th International Conference on Thermal Energy Storage. Ed.: M. Benner ... - Vol. 1},
  journal   = {Proceedings : University of Stuttgart, Germany, August 28th until September 1st, 2000 / Terrastock 2000, 8th International Conference on Thermal Energy Storage. Ed.: M. Benner ... - Vol. 1},
  publisher = {Inst. f{\"u}r Thermodynamik und W{\"a}rmetechnik},
  address   = {Stuttgart},
  isbn      = {3-9805274-1-7},
  pages     = {433 -- 439},
  year      = {2000},
  language  = {en}
}
@article{GruetersMueller1981,
  author    = {Gr{\"u}ters, Hugo and M{\"u}ller, C. H.},
  title     = {Anwendung der Cosseratschen Kontinuumstheorie auf den ebenen Verbundk{\"o}rper},
  series = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik : ZAMM. 61 (1981)},
  journal   = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik : ZAMM. 61 (1981)},
  isbn      = {0044-2267},
  pages     = {T92 -- T94},
  year      = {1981},
  language  = {de}
}
@article{GruetersMuellerWillms1983,
  author    = {Gr{\"u}ters, Hugo and M{\"u}ller, C. H. and Willms, H.},
  title     = {Ein Beitrag zur Berechnung von Gusseigenspannungen in Rohren},
  series = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik : ZAMM = Journal of applied mathematics and mechanics. 63 (1983)},
  journal   = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik : ZAMM = Journal of applied mathematics and mechanics. 63 (1983)},
  isbn      = {0044-2267},
  pages     = {T160 -- T163},
  year      = {1983},
  language  = {de}
}
@article{GruetersMueller1979,
  author    = {Gr{\"u}ters, Hugo and M{\"u}ller, C. H.},
  title     = {Experimentell-rechnerische Ermittlung von Eigenspannungen},
  series = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik : ZAMM = Journal of applied mathematics and mechanics. 59 (1979)},
  journal   = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik : ZAMM = Journal of applied mathematics and mechanics. 59 (1979)},
  isbn      = {0044-2267},
  pages     = {T184 -- T186},
  year      = {1979},
  language  = {de}
}
@article{KloockPoghossianSchumacheretal.2006,
  author    = {Kloock, Joachim P. and Poghossian, Arshak and Schumacher, K. and Rosenkranz, C. and Schultze, J. W. and M{\"u}ller-Veggian, Mattea and Sch{\"o}ning, Michael Josef},
  title     = {Funktionspr{\"u}fung und Charakterisierung von ionensensitiven Feldeffekttransistoren (ISFETs) auf Waferebene mittels Mikrotropfenzelle f{\"u}r den zuk{\"u}nftigen Einsatz in der Sensorproduktion},
  series = {Sensoren und Messsysteme 2006 : Vortr{\"a}ge der 13. ITG/GMA-Fachtagung vom 13. bis 14. M{\"a}rz 2006 in Freiburg/Breisgau / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ; VDE/VDI-Gesellschaft Mess- und Automatisierungstechnik (GMA). Wiss. Tagungsleitung: L. M. Reindl},
  journal   = {Sensoren und Messsysteme 2006 : Vortr{\"a}ge der 13. ITG/GMA-Fachtagung vom 13. bis 14. M{\"a}rz 2006 in Freiburg/Breisgau / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ; VDE/VDI-Gesellschaft Mess- und Automatisierungstechnik (GMA). Wiss. Tagungsleitung: L. M. Reindl},
  publisher = {VDE-Verl.},
  address   = {Berlin},
  isbn      = {3-8007-2939-3},
  pages     = {257 -- 260},
  year      = {2006},
  language  = {de}
}
@article{StreunChavanLameetal.2006,
  author    = {Streun, M. and Chavan, U. and Lame, H. and Parl, C. and M{\"u}ller-Veggian, Mattea and Ziemons, Karl},
  title     = {Treating the Gain Non-Uniformity of Multi Channel PMTs by Channel-Specific Trigger Levels},
  series = {2006 IEEE Nuclear Science Symposium Conference Record, Vol. 2.},
  journal   = {2006 IEEE Nuclear Science Symposium Conference Record, Vol. 2.},
  address   = {San Diego, CA},
  issn      = {1082-3654},
  pages     = {1301 -- 1304},
  year      = {2006},
  language  = {en}
}
@article{EnningJenayehMuelleretal.1997,
  author    = {Enning, Manfred and Jenayeh, I. and M{\"u}ller, C. and Rake, Heinrich},
  title     = {Development and realization of a manipulator for automatic decoupling of freight cars in marshalling yards / Jenayeh, I. ; M{\"u}ller, C. ; Enning, Manfred ; Rake, Heinrich ; Peter, J.},
  year      = {1997},
  language  = {en}
}
@article{EnningJenayehMuelleretal.1998,
  author    = {Enning, Manfred and Jenayeh, I. and M{\"u}ller, C. and Kositza, N.},
  title     = {Mechatronics in automating shunting processes in marshalling yards / Jenayeh, I. ; M{\"u}ller, C.; Kositza, N. ; Enning, M. ; Rake, H.},
  series = {Mechatronics '98 : proceedings of the 6th UK Mechatronics Forum International Conference, Sk{\"o}vde, Sweden, 9-11 September 1998},
  journal   = {Mechatronics '98 : proceedings of the 6th UK Mechatronics Forum International Conference, Sk{\"o}vde, Sweden, 9-11 September 1998},
  publisher = {Pergamon},
  address   = {Amsterdam},
  isbn      = {0-08-043339-1},
  pages     = {xxi, 918 S. : graph. Darst.},
  year      = {1998},
  language  = {en}
}
@article{EnningJenayehMuelleretal.1998,
  author    = {Enning, Manfred and Jenayeh, I. and M{\"u}ller, C. and Kositza, N.},
  title     = {A New Approach for Automating Shunting Processes in Marshalling Yards / Jenayeh, I.; M{\"u}ller, C. ; Kositza, N. ; Enning, M. ; Rake, H.},
  series = {Computational Engineering in Systems Applications : 2nd IMACS International Multiconference CESA'98; [abstracts; Nabeul-Hammamet, Tunisia, April 1 - 4, 1998] / ed. by Pierre Borne},
  journal   = {Computational Engineering in Systems Applications : 2nd IMACS International Multiconference CESA'98; [abstracts; Nabeul-Hammamet, Tunisia, April 1 - 4, 1998] / ed. by Pierre Borne},
  publisher = {UCIS},
  address   = {Villeneuve d'Ascq},
  pages     = {338 -- 343},
  year      = {1998},
  language  = {en}
}
@article{LangenZiemonsKiwitetal.1997,
  author    = {Langen, Karl J. and Ziemons, Karl and Kiwit, J{\"u}rgen C. W. and Herzog, Hans and Kuwert, Torsten and Bock, Wolfgang and St{\"o}cklin, Gerhard and Feinendegen, Ludwig E. and M{\"u}ller-G{\"a}rtner, Hans-W.},
  title     = {3-[123I]iodo-α-methyltyrosine and [methyl-11C]-L-methionine uptake in cerebral gliomas: a compara-tive study using SPECT and PET},
  series = {Journal of Nuclear Medicine},
  volume    = {38},
  journal   = {Journal of Nuclear Medicine},
  number    = {4},
  isbn      = {0161-5505},
  pages     = {517 -- 522},
  year      = {1997},
  language  = {en}
}
@article{SchmidtLangenHerzogetal.1997,
  author    = {Schmidt, Daniela and Langen, Karl-J. and Herzog, Hans and Wirths, Jochen and Holschbach, Markus and Kiwit, J{\"u}rgen C. W. and Ziemons, Karl and Coenen, Heinz-H. and M{\"u}ller-G{\"a}rtner, Hans-W.},
  title     = {Whole-body kinetics and dosimetry of L-3[123I]-iodo-α-methyltyrosine},
  series = {European Journal of Nuclear Medicine},
  volume    = {24},
  journal   = {European Journal of Nuclear Medicine},
  number    = {9},
  isbn      = {1619-7089},
  pages     = {1162 -- 1166},
  year      = {1997},
  language  = {en}
}
@article{HaagZontarSchleupenetal.2014,
  author    = {Haag, S. and Zontar, D. and Schleupen, Josef and M{\"u}ller, T. and Brecher, C.},
  title     = {Chain of refined perception in self-optimizing assembly of micro-optical systems},
  series = {Journal of sensors and sensor systems},
  volume    = {3},
  journal   = {Journal of sensors and sensor systems},
  number    = {1},
  publisher = {Copernicus Publ.},
  address   = {G{\"o}ttingen},
  issn      = {2194-878X},
  doi       = {10.5194/jsss-3-87-2014},
  pages     = {87 -- 95},
  year      = {2014},
  abstract  = {Today, the assembly of laser systems requires a large share of manual operations due to its complexity regarding the optimal alignment of optics. Although the feasibility of automated alignment of laser optics has been shown in research labs, the development effort for the automation of assembly does not meet economic requirements - especially for low-volume laser production. This paper presents a model-based and sensor-integrated assembly execution approach for flexible assembly cells consisting of a macro-positioner covering a large workspace and a compact micromanipulator with camera attached to the positioner. In order to make full use of available models from computer-aided design (CAD) and optical simulation, sensor systems at different levels of accuracy are used for matching perceived information with model data. This approach is named "chain of refined perception", and it allows for automated planning of complex assembly tasks along all major phases of assembly such as collision-free path planning, part feeding, and active and passive alignment. The focus of the paper is put on the in-process image-based metrology and information extraction used for identifying and calibrating local coordinate systems as well as the exploitation of that information for a part feeding process for micro-optics. Results will be presented regarding the processes of automated calibration of the robot camera as well as the local coordinate systems of part feeding area and robot base.},
  language  = {en}
}
@article{LuisierLempiaeinenScherbichleretal.2014,
  author    = {Luisier, Rapha{\"e}lle and Lempi{\"a}inen, Harri and Scherbichler, Nina and Braeuning, Albert and Geissler, Miriam and Dubost, Valerie and M{\"u}ller, Arne and Scheer, Nico and Chibout, Salah-Dine and Hara, Hisanori and Picard, Frank and Theil, Diethilde and Couttet, Philippe and Vitobello, Antonio and Grenet, Olivier and Grasl-Kraupp, Bettina and Ellinger-Ziegelbauer, Heidrung and Thomson, John P. and Meehan, Richard R. and Elcombe, Clifford R. and Henderson, Colin J. and Wolf, C. Roland and Schwarz, Michael and Moulin, Pierre and Terranova, Remi and Moggs, Jonathan G.},
  title     = {Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors},
  series = {Toxicological Sciences},
  volume    = {139},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {https://doi.org/10.1093/toxsci/kfu038},
  pages     = {501 -- 511},
  year      = {2014},
  abstract  = {The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.},
  language  = {en}
}
@article{LempiaeinenCouttetBolognanietal.2012,
  author    = {Lempi{\"a}inen, Harri and Couttet, Philippe and Bolognani, Federico and M{\"u}ller, Arne and Dubost, Val{\´e}rie and Luisier, Rapha{\"e}lle and Rio-Espinola, Alberto del and Vitry, Veronique and Unterberger, Elif B. and Thomson, John P. and Treindl, Fridolin and Metzger, Ute and Wrzodek, Clemens and Hahne, Florian and Zollinger, Tulipan and Brasa, Sarah and Kalteis, Magdalena and Marcellin, Magali and Giudicelli, Fanny and Braeuning, Albert and Morawiec, Laurent and Zamurovic, Natasa and L{\"a}ngle, Ulrich and Scheer, Nico and Sch{\"u}beler, Dirk and Goodman, Jay and Chibout, Salah-Dine and Marlowe, Jennifer and Theil, Dietlinde and Heard, David J. and Grenet, Olivier and Zell, Andreas and Templin, Markus F. and Meehan, Richard R. and Wolf, Roland C. and Elcombe, Clifford R. and Schwarz, Michael and Moulin, Pierre and Terranova, R{\´e}mi and Moggs, Jonathan G.},
  title     = {Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion},
  series = {Toxicological Sciences},
  volume    = {131},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {10.1093/toxsci/kfs303},
  pages     = {375 -- 386},
  year      = {2012},
  abstract  = {The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.},
  language  = {en}
}