@article{DroopChenRadfordetal.2023,
  author    = {Droop, Philipp and Chen, Shaohuang and Radford, Melissa J. and Paulßen, Elisabeth and Gates, Byron D. and Reilly, Raymond M. and Radchenko, Valery and Hoehr, Cornelia},
  title     = {Synthesis of 197m/gHg labelled gold nanoparticles for targeted radionuclide therapy},
  series = {Radiochimica Acta},
  volume    = {111},
  journal   = {Radiochimica Acta},
  number    = {10},
  publisher = {De Gruyter},
  address   = {Berlin [u.a.]},
  issn      = {2193-3405},
  doi       = {10.1515/ract-2023-0144},
  pages     = {773 -- 779},
  year      = {2023},
  abstract  = {Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 h and 64.1 h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 μg (gold)/mL with an activity of 151 ± 93 kBq/mL (197gHg, time corrected to the end of bombardment).},
  language  = {en}
}