@article{ArtmannDigelZerlinetal.2009, author = {Artmann, Gerhard and Digel, Ilya and Zerlin, Kay and Maggakis-Kelemen, Christina and Linder, Peter and Porst, Dariusz and Kayser, Peter and Stadler, David and Dikta, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Hemoglobin senses body temperature}, series = {European Biophysics Journal}, volume = {38}, journal = {European Biophysics Journal}, number = {5}, isbn = {0175-7571}, pages = {589 -- 600}, year = {2009}, language = {en} } @article{BassamArtmannHescheleretal.2011, author = {Bassam, Rasha and Artmann, Gerhard and Hescheler, J{\"u}rgen and Graef, T. and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Arinkin, Vladimir and Gossmann, Matthias and Digel, Ilya}, title = {Alterations in human hemoglobin structure related to red blood cell storage}, year = {2011}, abstract = {The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing.}, subject = {H{\"a}moglobin}, language = {en} } @article{PreissLinderWendtetal.2011, author = {Preiß, C. and Linder, Peter and Wendt, K. and Krystek, M. and Digel, Ilya and Gossmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Bassam, Rasha and Artmann, Gerhard}, title = {Engineering technology for plant physiology and plant stress research}, year = {2011}, abstract = {Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.}, subject = {Pflanzenphysiologie}, language = {en} } @article{SeifarthSchehlLinderetal.2011, author = {Seifarth, Volker and Schehl, D. and Linder, Peter and Gossmann, Matthias and Digel, Ilya and Artmann, Gerhard and Porst, Dariusz and Preiß, C. and Kayser, Peter and Pack, O. and Temiz Artmann, Ayseg{\"u}l}, title = {Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds}, year = {2011}, abstract = {The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 \%. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.}, subject = {Tissue Engineering}, language = {en} } @article{ZhubanovaAknazarovMansurovetal.2010, author = {Zhubanova, Azhar A. and Aknazarov, S. K. and Mansurov, Zulkhair and Digel, Ilya and Kozhalakova, A. A. and Akimbekov, Nuraly Shardarbekovich and O'Heras, Carlos and Tazhibayeva, S. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials}, year = {2010}, abstract = {Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.}, subject = {Kohlenstofffaser}, language = {en} } @inproceedings{ArtmannDigelLinderetal.2011, author = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Temiz Artmann, Ayseg{\"u}l}, title = {Biophysical and Engineering Contributions to Plant Research}, year = {2011}, abstract = {Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in-situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.}, subject = {Pflanzenphysiologie}, language = {en} } @inproceedings{ArtmannStadlerEmbsetal.2010, author = {Artmann, Gerhard and Stadler, Andreas M. and Embs, Jan P. and Zaccai, Giuseppe and B{\"u}ldt, Georg and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l}, title = {The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]}, year = {2010}, abstract = {The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature}, subject = {H{\"a}moglobin}, language = {en} } @inproceedings{DigelTemizArtmannArtmannetal.2003, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Nojima, H.}, title = {Plasma cluster ions (PCI) influence on microbial cells viability : [abstract]}, year = {2003}, abstract = {Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new plasma cluster device releases into the air positive and negative ions, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. A lot of phenomenological tests of the PCI air purification technology on microbial cells have been conducted. And, in most cases, it has been shown that PCI demonstrate strongly pronounced killing effect. Although, the particular mechanisms of PCI action are still not evident. We studied variations in resistance to PCI among gram-positive airborne microorganisms, as well as some dose-dependent, spatial, cultural and biochemical properties of PCI action in respect of Staphylococcus spp, Enterococcus spp, Micrococcus spp.}, subject = {Clusterion}, language = {en} } @inproceedings{DigelTemizArtmannNojimaetal.2003, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard}, title = {Effects of plasma generated ions on bacteria : [poster]}, year = {2003}, abstract = {Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death.}, subject = {Clusterion}, language = {en} } @inproceedings{DigelTemizArtmannNojimaetal.2003, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard}, title = {Some peculiarities of application of cluster ions generated by plasma in respect of indoor air purification :[abstract]}, year = {2003}, abstract = {Recently, the SHARP Corporation, Japan, has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology using plasma discharge to generate cluster ions. The new plasma cluster device releases positive and negative ions into the air, which are able to decompose and deactivate harmful airborne substances by chemical reactions. Because cluster ions consist of positive and negative ions that normally exist in the natural world, they are completely harmless and safe to humans. The amount of ozone generated by cluster ions is less than 0.01 ppm, which is significantly less than the 0.05-ppm standard for industrial operations and consumer electronics. This amount, thus, has no harming effects whatsoever on the human body. But particular properties and chemical processes in PCI treatment are still under study. It has been shown that PCI in most cases show strongly pronounced irreversible killing effects in respect of airborne microflora due to free-radical induced reactions and can be considered as a potent technology to disinfect both home, medical and industrial appliances.}, subject = {Clusterion}, language = {en} } @article{AkimbekovMansurovJandosovetal.2013, author = {Akimbekov, Nuraly Shardarbekovich and Mansurov, Zulkhair and Jandosov, J. and Digel, Ilya and Gossmann, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A.}, title = {Wound healing activity of carbonized rice husk}, publisher = {Trans Tech Publications, Switzerland}, address = {B{\"a}ch}, year = {2013}, abstract = {The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.}, subject = {Wundheilung}, language = {en} } @inproceedings{DigelLeimenaDachwaldetal.2010, author = {Digel, Ilya and Leimena, W. and Dachwald, Bernd and Linder, Peter and Porst, Dariusz and Kayser, Peter and Funke, O. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {In-situ biological decontamination of an ice melting probe : [abstract]}, year = {2010}, abstract = {The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.}, subject = {Sonde}, language = {en} } @inproceedings{MansurovZhubanovaDigeletal.2008, author = {Mansurov, Zulkhair and Zhubanova, Azhar A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Savitskaja, Irina S. and Kozhalakova, A. A. and Kistaubaeva, Aida S.}, title = {The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials}, year = {2008}, abstract = {Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it's microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties - ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS.}, subject = {Kohlenstofffaser}, language = {en} } @inproceedings{DigelTemizArtmannNojimaetal.2003, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard}, title = {Plasma-generated cluster ions' effects on indoor microflora : [abstract]}, year = {2003}, abstract = {Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions® (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new Plasma Cluster Device releases positive and negative ions into the air, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. In the past, phenomenological tests on the efficacy of the PCI air purification technology on microbial cells have been conducted. In most cases, it has been shown that PCI demonstrated strongly pronounced killing effects on microorganisms. However, the particular mechanisms of PCI action still have to be uncovered.}, subject = {Clusterion}, language = {en} } @article{ArtmannBurnsCanavesetal.2004, author = {Artmann, Gerhard and Burns, Laura and Canaves, Jaume M. and Temiz Artmann, Ayseg{\"u}l}, title = {Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature}, series = {European Biophysics Journal. 33 (2004), H. 6}, journal = {European Biophysics Journal. 33 (2004), H. 6}, isbn = {1432-1017}, pages = {490 -- 496}, year = {2004}, language = {en} } @article{SadykovDigelTemizArtmannetal.2009, author = {Sadykov, Rustam and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Artmann, Gerhard and Savitskaya, Irina and Zhubanova, Azhar}, title = {Oral lead exposure induces dysbacteriosis in rats}, series = {Journal of Occupational Health. 51 (2009) (2009), H. 1}, journal = {Journal of Occupational Health. 51 (2009) (2009), H. 1}, isbn = {1348-9585}, pages = {64 -- 73}, year = {2009}, language = {en} } @article{DemirciKurulganDemirciTrzewiketal.2009, author = {Demirci, Taylan and Kurulgan Demirci, Eylem and Trzewik, J{\"u}rgen and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Sakizli, Meral and Temiz Artmann, Ayseg{\"u}l}, title = {Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress}, series = {IUBMB Life. 61 (2009), H. 3}, journal = {IUBMB Life. 61 (2009), H. 3}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {1521-6543}, pages = {311 -- 312}, year = {2009}, language = {en} } @article{LinderDigelTemizArtmannetal.2007, author = {Linder, Peter and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Kayser, Peter and Porst, Dariusz and Artmann, Gerhard}, title = {High-throughput testing of mechanical forces generated in thin cell and tissue layers}, series = {Tissue Engineering. 13 (2007), H. 7}, journal = {Tissue Engineering. 13 (2007), H. 7}, isbn = {1076-3279}, pages = {1778 -- 1778}, year = {2007}, language = {en} } @article{DemirciTrzewikLinderetal.2004, author = {Demirci, T. and Trzewik, J. and Linder, Peter and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison}, series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {1046 -- 1047}, year = {2004}, language = {en} } @article{DemirciTrzewikLinderetal.2004, author = {Demirci, T. and Trzewik, J. and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level}, series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {1030 -- 1031}, year = {2004}, language = {en} } @article{KurulganDemirciDemirciTrzewiketal.2011, author = {Kurulgan Demirci, Eylem and Demirci, T. and Trzewik, J{\"u}rgen and Linder, Peter and Karakulah, G. and Artmann, Gerhard and Sakizli, M. and Temiz Artmann, Ayseg{\"u}l}, title = {Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation}, series = {Cellular and molecular bioengineering. 4 (2011), H. 1}, journal = {Cellular and molecular bioengineering. 4 (2011), H. 1}, publisher = {Springer}, address = {Berlin}, isbn = {1865-5025}, pages = {46 -- 55}, year = {2011}, language = {en} } @article{AminTemizArtmannArtmannetal.2009, author = {Amin, Rashid and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Lazarovici, Philip and Lelkes, Peter I.}, title = {Permeability of an In Vitro Model of Blood Brain Barrier (BBB)}, series = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]}, journal = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]}, isbn = {978-3-540-92841-6}, pages = {81 -- 84}, year = {2009}, language = {en} } @article{LeimenaArtmannDachwaldetal.2010, author = {Leimena, W. and Artmann, Gerhard and Dachwald, Bernd and Temiz Artmann, Ayseg{\"u}l and Gossmann, Matthias and Digel, Ilya}, title = {Feasibility of an in-situ microbial decontamination of an ice-melting probe}, series = {Eurasian Chemico-Technological Journal. 12 (2010), H. 2}, journal = {Eurasian Chemico-Technological Journal. 12 (2010), H. 2}, isbn = {1562-3920}, pages = {145 -- 150}, year = {2010}, language = {en} } @article{KurulganDemirciDemirciLinderetal.2012, author = {Kurulgan Demirci, Eylem and Demirci, Taylan and Linder, Peter and Trzewik, J{\"u}rgen and Gierkowski, Jessica Ricarda and Gossmann, Matthias and Kayser, Peter and Porst, Dariusz and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells}, series = {Journal of Bioscience and Bioengineering}, volume = {113}, journal = {Journal of Bioscience and Bioengineering}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1347-4421}, doi = {10.1016/j.jbiosc.2012.03.019}, pages = {212 -- 219}, year = {2012}, abstract = {All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.}, language = {en} } @article{BassamHeschelerTemizArtmannetal.2012, author = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya}, title = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin}, series = {BMC Biophysics}, volume = {5}, journal = {BMC Biophysics}, publisher = {BioMed Central}, address = {London}, issn = {2046-1682}, doi = {10.1186/2046-1682-5-16}, pages = {Art. 16}, year = {2012}, abstract = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.}, language = {en} } @article{ZerlinKasischkeDigeletal.2007, author = {Zerlin, Kay and Kasischke, Nicole and Digel, Ilya and Maggakis-Kelemen, Christina and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Linder, Peter and Artmann, Gerhard}, title = {Structural transition temperature of hemoglobins correlates with species' body temperature}, series = {European Biophysics Journal. 37 (2007), H. 1}, journal = {European Biophysics Journal. 37 (2007), H. 1}, isbn = {1432-1017}, pages = {1 -- 10}, year = {2007}, language = {en} } @article{TrzewikTemizArtmannLinderetal.2004, author = {Trzewik, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Linder, Peter and Demirci, T. and Digel, Ilya and Artmann, Gerhard}, title = {Evaluation of lateral mechanical tension in thin-film tissue constructs}, series = {Annals of Biomedical Engineering. 32 (2004), H. 9}, journal = {Annals of Biomedical Engineering. 32 (2004), H. 9}, isbn = {1573-9686}, pages = {1243 -- 1251}, year = {2004}, language = {en} } @article{DigelTemizArtmannNishikawaetal.2004, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K. and Artmann, Gerhard}, title = {Cluster air-ion effects on bacteria and moulds}, series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {1040 -- 1041}, year = {2004}, language = {en} } @article{KurulganDemirciLinderDemircietal.2009, author = {Kurulgan Demirci, Eylem and Linder, Peter and Demirci, Taylan and Trzewik, J{\"u}rgen and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Contractile tension of endothelial cells: An LPS based in-vitro sepsis model}, series = {IUBMB Life. 61 (2009), H. 3}, journal = {IUBMB Life. 61 (2009), H. 3}, publisher = {Wiley}, address = {Weinheim}, isbn = {1521-6543}, pages = {307 -- 308}, year = {2009}, language = {en} } @article{BassamDigelHescheleretal.2013, author = {Bassam, Rasha and Digel, Ilya and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences}, series = {BMC Biophysics}, journal = {BMC Biophysics}, publisher = {BioMed Central}, address = {London}, isbn = {2046-1682}, url = {http://nbn-resolving.de/10.1186/2046-1682-6-1}, pages = {1 -- 14}, year = {2013}, language = {en} } @article{MiciliValterOflazetal.2013, author = {Micili, Serap C. and Valter, Markus and Oflaz, Hakan and Ozogul, Candan and Linder, Peter and F{\"o}ckler, Nicole and Artmann, Gerhard and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l}, title = {Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes}, series = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine}, volume = {Vol. 227}, journal = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine}, number = {No. 4}, publisher = {Sage}, address = {London}, issn = {0046-2039 (Print) ; 2041-3033 (E-Journal)}, pages = {393 -- 401}, year = {2013}, language = {en} } @article{ArinkinDigelPorstetal.2014, author = {Arinkin, Vladimir and Digel, Ilya and Porst, Dariusz and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application}, series = {BMC bioinformatics}, volume = {15}, journal = {BMC bioinformatics}, number = {55}, issn = {1471-2105}, doi = {10.1186/1471-2105-15-55}, pages = {1 -- 8}, year = {2014}, abstract = {Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1\% and reached 100\% in one of the best ANN.}, language = {en} } @article{SeifarthGossmannGrosseetal.2015, author = {Seifarth, Volker and Goßmann, Matthias and Grosse, J. O. and Becker, C. and Heschel, I. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds}, series = {Urologia Internationalis}, volume = {2015}, journal = {Urologia Internationalis}, number = {95}, publisher = {Karger}, address = {Basel}, issn = {0042-1138}, doi = {10.1159/000368419}, pages = {106 -- 113}, year = {2015}, language = {en} } @incollection{DigelSadykovTemizArtmannetal.2015, author = {Digel, Ilya and Sadykov, R. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations}, series = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies}, booktitle = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies}, publisher = {Nova Science Publ.}, isbn = {9781634826990}, pages = {75 -- 99}, year = {2015}, language = {en} } @article{GossmannFrotscherLinderetal.2016, author = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells}, series = {Cellular physiology and biochemistry}, volume = {38}, journal = {Cellular physiology and biochemistry}, number = {3}, publisher = {Karger}, address = {Basel}, issn = {1421-9778 (Online)}, doi = {10.1159/000443124}, pages = {1182 -- 1198}, year = {2016}, abstract = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.}, language = {en} } @article{SeifarthGrosseGrossmannetal.2017, author = {Seifarth, Volker and Grosse, Joachim O. and Grossmann, Matthias and Janke, Heinz Peter and Arndt, Patrick and Koch, Sabine and Epple, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation}, series = {Journal of Biomaterials Applications}, volume = {32}, journal = {Journal of Biomaterials Applications}, number = {3}, publisher = {Sage}, address = {London}, issn = {1530-8022}, doi = {10.1177/0885328217723178}, pages = {321 -- 330}, year = {2017}, language = {en} } @book{ArtmannTemizArtmannZhubanovaetal.2018, author = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, title = {Biological, physical and technical basics of cell engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7903-0}, pages = {xxiv, 481 Seiten ; Illustrationen, Diagramme}, year = {2018}, language = {en} } @incollection{ArtmannMeruvuKizildagetal.2018, author = {Artmann, Gerhard and Meruvu, Haritha and Kizildag, Sefa and Temiz Artmann, Ayseg{\"u}l}, title = {Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_7}, pages = {157 -- 192}, year = {2018}, abstract = {Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative "CellDrum technology" was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.}, language = {en} } @incollection{DuongSeifarthTemizArtmannetal.2018, author = {Duong, Minh Tuan and Seifarth, Volker and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Staat, Manfred}, title = {Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_9}, pages = {209 -- 232}, year = {2018}, abstract = {Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.}, language = {en} } @inproceedings{BayerHeschelerArtmannetal.2019, author = {Bayer, Robin and Hescheler, J{\"u}rgen and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Treating arterial hypertension in a cell culture well}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {5 -- 6}, year = {2019}, abstract = {Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the "Deutsche Bluthochdruck Liga" this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.}, language = {en} } @article{TemizArtmannKurulgandemirciFıratetal.2021, author = {Temiz Artmann, Ayseg{\"u}l and Kurulgan demirci, Eylem and F{\i}rat, Ipek Seda and Oflaz, Hakan and Artmann, Gerhard}, title = {Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers}, series = {SHOCK}, journal = {SHOCK}, publisher = {Wolters Kluwer}, address = {K{\"o}ln}, issn = {1540-0514}, doi = {10.1097/SHK.0000000000001845}, year = {2021}, language = {en} } @article{UysalCreutzFiratetal.2022, author = {Uysal, Karya and Creutz, Till and Firat, Ipek Seda and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l}, title = {Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments}, series = {Polymers}, volume = {14}, journal = {Polymers}, number = {11}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, pages = {2213}, year = {2022}, abstract = {Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3-4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications.}, language = {en} } @article{BayerTemizArtmannDigeletal.2020, author = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen}, title = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model}, series = {Cellular Physiology and Biochemistry}, volume = {54}, journal = {Cellular Physiology and Biochemistry}, publisher = {Cell Physiol Biochem Press}, address = {D{\"u}sseldorf}, issn = {1421-9778}, doi = {10.33594/000000225}, pages = {371 -- 383}, year = {2020}, abstract = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.}, language = {en} } @article{UysalFiratCreutzetal.2022, author = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l}, title = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes}, series = {membranes}, volume = {2023}, journal = {membranes}, number = {13(1)}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/membranes13010022}, pages = {Artikel 22}, year = {2022}, abstract = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.}, language = {en} } @article{AkimbekovZhubanovaMansurovetal.2010, author = {Akimbekov, N. Sh. and Zhubanova, A. A. and Mansurov, Z. A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Use of Carbonized Rise Shell for the local treatment of wounds}, series = {Eurasian ChemTech Journal}, volume = {12}, journal = {Eurasian ChemTech Journal}, number = {2}, publisher = {Institute of Combustion Problems}, address = {Almaty}, issn = {2522-4867}, doi = {10.18321/ectj35}, pages = {133 -- 138}, year = {2010}, abstract = {On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.}, language = {en} } @article{KozhalakovaZhubanovaMansurovetal.2010, author = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell}, series = {Science of Central Asia (2010)}, journal = {Science of Central Asia (2010)}, pages = {50 -- 54}, year = {2010}, language = {en} } @article{KurzLinderTrzewiketal.2010, author = {Kurz, R. and Linder, Peter and Trzewik, J{\"u}rgen and R{\"u}ffer, M. and Artmann, Gerhard and Digel, Ilya and Rothermel, A. and Robitzki, A. and Temiz Artmann, Ayseg{\"u}l}, title = {Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes}, series = {Medical and Biological Engineering and Computing}, volume = {48}, journal = {Medical and Biological Engineering and Computing}, number = {1}, publisher = {Springer Nature}, address = {Cham}, issn = {1741-0444}, doi = {10.1007/s11517-009-0552-y}, pages = {59 -- 65}, year = {2010}, abstract = {The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.}, language = {en} } @article{LiShiLandsmannetal.1998, author = {Li, Anlan and Shi, Young de and Landsmann, B. and Schankowski-Bouvier, P. and Dikta, Gerhard and Bauer, U. and Artmann, Gerhard}, title = {Hemorheology and walking distance of Peripheral Arterial Occlusive Disease patients during treatment with Ginkgo-biloba extract}, series = {Acta Pharmacologica Sinica = ZHONGUO YAOLI XUEBAO. 19 (1998), H. 5}, journal = {Acta Pharmacologica Sinica = ZHONGUO YAOLI XUEBAO. 19 (1998), H. 5}, isbn = {1745-7254}, pages = {417 -- 421}, year = {1998}, language = {en} } @article{ZhubanovaDigelNojimaetal.2007, author = {Zhubanova, Azhar A. and Digel, Ilya and Nojima, H. and Artmann, Gerhard}, title = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology}, year = {2007}, abstract = {The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.}, subject = {Clusterion}, language = {en} } @inproceedings{DachwaldXuFeldmannetal.2011, author = {Dachwald, Bernd and Xu, Changsheng and Feldmann, Marco and Plescher, Engelbert and Digel, Ilya and Artmann, Gerhard}, title = {Development and testing of a subsurface probe for detection of life in deep ice : [abstract]}, year = {2011}, abstract = {We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named "IceMole", is currently developed, built, and tested at the FH Aachen University of Applied Sciences' Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).}, subject = {Eisschicht}, language = {en} } @inproceedings{BassamDigelArtmann2009, author = {Bassam, Rasha and Digel, Ilya and Artmann, Gerhard}, title = {Effect of nitric oxide on protein thermal stability : [abstract]}, year = {2009}, abstract = {As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not.}, subject = {Stickstoffmonoxid}, language = {en} } @inproceedings{DigelDachwaldArtmannetal.2009, author = {Digel, Ilya and Dachwald, Bernd and Artmann, Gerhard and Linder, Peter and Funke, O.}, title = {A concept of a probe for particle analysis and life detection in icy environments}, year = {2009}, abstract = {A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa's ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live.}, subject = {Sonde}, language = {en} } @inproceedings{StadlerEmbsZerlinetal.2007, author = {Stadler, Andreas M. and Embs, Jan P. and Zerlin, Kay and Digel, Ilya and Artmann, Gerhard and Zaccai, Joe and B{\"u}ldt, Georg}, title = {Temperature transitions of hemoglobin and cytosolic water diffusion in human red blood cells : [poster]}, year = {2007}, abstract = {Background Hemoglobin interactions in red blood cells Hemoglobin dynamics in human red blood cells Diffusion of H2O in red blood cells}, subject = {Erythrozyt}, language = {en} } @article{ArtmannTrzewikAtes2002, author = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Ates, M.}, title = {A novel method to quantify mechanical tension in cell monolayers. Trzewik, J{\"u}rgen; Ates, M., Artmann, Gerhard Michael}, series = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1}, journal = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1}, isbn = {0013-5585}, pages = {379 -- 381}, year = {2002}, language = {en} } @article{MaggakisKelemenBiselliArtmann2002, author = {Maggakis-Kelemen, Christina and Biselli, Manfred and Artmann, Gerhard}, title = {Determination of the elastic shear modulus of cultured human red blood cells}, series = {Biomedizinische Technik. 47 (2002), H. Suppl. 1 Pt. 1}, journal = {Biomedizinische Technik. 47 (2002), H. Suppl. 1 Pt. 1}, isbn = {0013-5585}, pages = {106 -- 109}, year = {2002}, language = {en} } @article{ArtmannZhouStacheBuettneretal.2002, author = {Artmann, Gerhard and Zhou-Stache, J. and Buettner, R. and Mittermayer, C. [u.a.]}, title = {Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K.}, series = {Medical and Biological Engineering and Computing. 40 (2002), H. 6}, journal = {Medical and Biological Engineering and Computing. 40 (2002), H. 6}, isbn = {0140-0118}, pages = {698 -- 703}, year = {2002}, language = {en} } @article{ArtmannTrzewikMallipattuetal.2001, author = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Mallipattu, S. K. and Delano, F. A. [u.a.]}, title = {Evidence for a second valve system in Lymphatics: Endothelial Microvalves. Trzewik, J{\"u}rgen; Mallipattu, S. K.; Artmann, Gerhard Michael; Delano, F. A.; Schmid-Schonbein, G. W}, series = {The FASEB Journal. 15 (2001)}, journal = {The FASEB Journal. 15 (2001)}, isbn = {1530-6860}, pages = {1711 -- 1717}, year = {2001}, language = {en} } @article{ArtmannBaeumlerVoigtetal.2000, author = {Artmann, Gerhard and B{\"a}umler, H. and Voigt, A. and Mitl{\"o}hner, R. [u.a.]}, title = {Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. B{\"a}umler, H., Artmann, Gerhard Michael; Voigt, A., Mitl{\"o}hner, R., Neu, B., Kiesewetter, H.}, series = {Journal of Microencapsulation. 17 (2000), H. 5}, journal = {Journal of Microencapsulation. 17 (2000), H. 5}, isbn = {1464-5246}, pages = {651 -- 655}, year = {2000}, language = {en} } @article{ArtmannGorbatenkovaPanasenko2000, author = {Artmann, Gerhard and Gorbatenkova, E. A. and Panasenko, O. M.}, title = {Hypochlorous acid and human blood low density lipoproteins modified by hypochlorous acid increase erythrocyte adhesion to endothelial cells. Gorbatenkova, E. A.; Artmann, Gerhard Michael; Panasenko, O. M.}, series = {Membrane and cell biology. 13 (2000), H. 4}, journal = {Membrane and cell biology. 13 (2000), H. 4}, isbn = {1023-6597}, pages = {537 -- 546}, year = {2000}, language = {en} } @article{ArtmannKelemenChien2001, author = {Artmann, Gerhard and Kelemen, C. and Chien, S.}, title = {Temperature transition of human hemoglobin at body temperature: effects of calcium. Kelemen, C.; Chien, S.; Artmann, Gerhard Michael}, series = {Biophysical journal. 80 (2001), H. 6}, journal = {Biophysical journal. 80 (2001), H. 6}, isbn = {1542-0086}, pages = {2622 -- 2630}, year = {2001}, language = {en} } @article{ArtmannHueckHollwegetal.2000, author = {Artmann, Gerhard and Hueck, I. S. and Hollweg, H. G. and Schmid-Sch{\"o}nbein, G. W.}, title = {Chlorpromazine modulates the Morphological Macro- and Microstructure of Endothelial Cells. Hueck, I. S.; Hollweg, H. G.; Schmid-Sch{\"o}nbein, G. W.; Artmann, Gerhard Michael}, series = {American Journal of Physiology. Cell Physiology. 278 (2000), H. 5}, journal = {American Journal of Physiology. Cell Physiology. 278 (2000), H. 5}, isbn = {1522-1563}, pages = {873 -- 878}, year = {2000}, language = {en} } @article{ArtmannLiSeipeltetal.1999, author = {Artmann, Gerhard and Li, Anlan and Seipelt, H. and M{\"u}ller, C. [u.a.]}, title = {Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; M{\"u}ller, C.;Shi, Yong de; Artmann, Gerhard Michael}, series = {Pharmacology and Toxicology. 85 (1999)}, journal = {Pharmacology and Toxicology. 85 (1999)}, isbn = {0902-9938}, pages = {206 -- 211}, year = {1999}, language = {en} } @article{ArtmannHovavGoldfarbetal.1999, author = {Artmann, Gerhard and Hovav, T. and Goldfarb, A. and Yedgar, S. [u.a.]}, title = {Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells. Hovav, T., Goldfarb, A.; Artmann, Gerhard Michael, Yedgar, S.; Barstein, G.}, series = {British Journal of Haematology. 106 (1999), H. 1}, journal = {British Journal of Haematology. 106 (1999), H. 1}, isbn = {1365-2141}, pages = {178 -- 181}, year = {1999}, language = {en} } @article{ArtmannKelemenPorstetal.1998, author = {Artmann, Gerhard and Kelemen, Christina and Porst, Dariusz and B{\"u}ldt, G. [u.a.]}, title = {Temperature transitions of protein properties in human red blood cells. Artmann, Gerhard Michael, Kelemen, Christina; Porst, D.; B{\"u}ldt, G.; Chien, S.}, series = {Biophysical Journal. 75 (1998), H. 6}, journal = {Biophysical Journal. 75 (1998), H. 6}, isbn = {1542-0086}, pages = {3179 -- 3183}, year = {1998}, language = {en} } @article{ArtmannShiAgostietal.1998, author = {Artmann, Gerhard and Shi, Young de and Agosti, R. and Longhini, E.}, title = {A modified casson equation to characterize blood rheology for hypertension. Shi, Young de; Artmann, Gerhard Michael; Agosti, R.; Longhini, E.}, series = {Clinical Hemorheology Microcirculation. 19 (1998), H. 2}, journal = {Clinical Hemorheology Microcirculation. 19 (1998), H. 2}, isbn = {1386-0291}, pages = {115 -- 127}, year = {1998}, language = {en} } @article{ArtmannSchikarsky1993, author = {Artmann, Gerhard and Schikarsky, C.}, title = {Ginkgo Biloba extract (EGb 761) protects red blood cells from oxidative damage. Artmann, Gerhard Michael; Schikarsky, C.}, series = {Clinical Hemorheology. 13 (1993), H. 4}, journal = {Clinical Hemorheology. 13 (1993), H. 4}, isbn = {0271-5198}, pages = {529 -- 539}, year = {1993}, language = {en} } @article{Artmann1986, author = {Artmann, Gerhard}, title = {A microscopic photometric method for measuring erythrocyte deformability. Artmann, Gerhard Michael}, series = {Clinical Hemorheology. 6 (1986)}, journal = {Clinical Hemorheology. 6 (1986)}, isbn = {0271-5198}, pages = {617 -- 627}, year = {1986}, language = {en} } @article{ArtmannSchmidSchoenbeinGrebeetal.1988, author = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Grebe, R. and Teitel, P. [u.a.]}, title = {Restoration of Microsieve Filterability of Human Red Cells After Exposure to Hyperosmolarity and Lactazidosis: Effect of Vinpocetine. Schmid-Sch{\"o}nbein, H.; Grebe, R.; Teitel, P.; Artmann, Gerhard Michael, Eschweiler, H.; Schr{\"o}der, Susanne}, series = {Drug Development Research. 14 (1988), H. 3-4}, journal = {Drug Development Research. 14 (1988), H. 3-4}, isbn = {1098-2299}, pages = {205 -- 211}, year = {1988}, language = {en} } @article{ArtmannSchmidSchoenbeinSchroederetal.1988, author = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Schr{\"o}der, Susanne and Grebe, R. [u.a.]}, title = {Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Sch{\"o}nbein, H.; Schr{\"o}der, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P.}, series = {Arzneimittelforschung. 38 (1988), H. 5}, journal = {Arzneimittelforschung. 38 (1988), H. 5}, isbn = {0004-4172}, pages = {710 -- 716}, year = {1988}, language = {en} } @article{ArtmannZang1990, author = {Artmann, Gerhard and Zang, Werner}, title = {Fully automatic measurement of rheologic parameters of red blood cells = Laborautomat zur Messung mechanischer Eigenschaften roter Blutzellen}, series = {Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3}, journal = {Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3}, isbn = {0013-5585}, pages = {94 -- 96}, year = {1990}, language = {en} } @article{ArtmannSungHornetal.1997, author = {Artmann, Gerhard and Sung, K.-L. Paul and Horn, Thomas and Whittemore, Darren [u.a.]}, title = {Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Artmann, Gerhard Michael; Sung, K.-L. Paul; Horn, Thomas; Whittemore, Darren; Norwich, Gerald; Chien, Shu}, series = {Biophysical journal. 72 (1997), H. 3}, journal = {Biophysical journal. 72 (1997), H. 3}, isbn = {1542-0086}, pages = {1434 -- 1441}, year = {1997}, language = {en} } @article{ArtmannLiZiemeretal.1996, author = {Artmann, Gerhard and Li, Anlan and Ziemer, J. and Schneider, G. [u.a.]}, title = {A photometric method to analyze induced erythrocyte shape changes. Artmann, Gerhard Michael; Li, Anlan; Ziemer, J.; Schneider, G.; Sahm, U.: ; Ziemer, J.; Schneider, G.; Sahm, U.}, series = {Biorheology. 33 (1996), H. 3}, journal = {Biorheology. 33 (1996), H. 3}, isbn = {0006-355x}, pages = {251 -- 265}, year = {1996}, language = {en} } @article{Artmann1996, author = {Artmann, Gerhard}, title = {2nd International Conference on Medical Biorheology (ICMB). Shanghai, China, September 13-15, 1995. Shi, Young de, Artmann, Gerhard Michael, Meiselman, Herbert J.}, series = {Biorheology. 33 (1996), H. 6}, journal = {Biorheology. 33 (1996), H. 6}, isbn = {0006-355x}, pages = {505 -- 507}, year = {1996}, language = {en} } @article{Artmann1995, author = {Artmann, Gerhard}, title = {Microscopic photometric quantification of stiffness and relaxation time of red blood cells in a flow chamber. Artmann, Gerhard Michael}, series = {Biorheology. 32 (1995), H. 5}, journal = {Biorheology. 32 (1995), H. 5}, isbn = {0006-355x}, pages = {553 -- 570}, year = {1995}, language = {en} } @article{ArtmannLi1994, author = {Artmann, Gerhard and Li, Anlan}, title = {Dihydroergocryptine maintains erythrocyte fluidity in acidotic and hyperosmolar suspensions modelling hypoxic and ischemic microcirculation. Li, Anlan; Artmann, Gerhard Michael}, series = {Clinical Hemorheology. 15 (1994), H. 2}, journal = {Clinical Hemorheology. 15 (1994), H. 2}, isbn = {0271-5198}, pages = {133 -- 146}, year = {1994}, language = {en} } @article{ArtmannSchmidSchoenbein1987, author = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H.}, title = {The microscope-photometrical-monolayer-technique- a new principle for analyzing the distribution of rheological responses in pathological and experimentally modified red cell populations. Artmann, Gerhard Michael; Schmid-Sch{\"o}nbein, H.}, series = {Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987}, journal = {Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987}, publisher = {Excerpta Medica}, address = {Amsterdam [u.a.]}, isbn = {0444809511}, pages = {475 -- 477}, year = {1987}, language = {en} } @article{ArtmannTeitelSchmidSchoenbein1987, author = {Artmann, Gerhard and Teitel, P. and Schmid-Sch{\"o}nbein, H.}, title = {Variable rheologische Antwort der Erythrozyten auf den Einfluß von Xantinderivaten (Coffein): Experimentelle Differenzierung von "Responders" und "Nonresponders"}, series = {11. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, journal = {11. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, publisher = {Karger [u.a.]}, address = {Basel [u.a.]}, pages = {100 -- 105}, year = {1987}, language = {de} } @article{ArtmannGrebeHomrighausenetal.1988, author = {Artmann, Gerhard and Grebe, R. and Homrighausen, A. and Wolff, H. and [u.a.],}, title = {Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Sch{\"o}nbein, H.}, series = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, journal = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, publisher = {Karger [u.a.]}, address = {Basel [u.a.]}, pages = {196 -- 200}, year = {1988}, language = {en} } @article{ArtmannKellerHaasetal.1991, author = {Artmann, Gerhard and Keller, U. and Haas, J. and Amort, U. and Zang, Werner and Karschies, S.}, title = {Technik und ausgew{\"a}hlte Applikationen eines Membranbioassays roter Blutzellen}, series = {Biomedizinische Technik = Biomedical engineering. 36 (1991)}, volume = {36}, journal = {Biomedizinische Technik = Biomedical engineering. 36 (1991)}, number = {S1}, isbn = {0013-5585}, pages = {450 -- 451}, year = {1991}, language = {de} } @article{ArtmannMontanusTeitel1991, author = {Artmann, Gerhard and Montanus, M. and Teitel, P.}, title = {Die photometrische Kapillaraggregation- ein neues Verfahren zur Messung der Erythrozytenaggregation. Montanus, M.; Artmann, Gerhard Michael; Teitel, P.}, series = {Biomedizinische Technik = Biomedical engineering. 36 (1991)}, journal = {Biomedizinische Technik = Biomedical engineering. 36 (1991)}, isbn = {0013-5585}, pages = {213 -- 215}, year = {1991}, language = {de} } @article{ArtmannWitte1991, author = {Artmann, Gerhard and Witte, Ch.}, title = {Expertensystem f{\"u}r Personal Computer zur Strukturbestimmung des Circulus Arteriosus Willisii mittels transkranieller Dopplersonografie. Witte, Ch.; Artmann, Gerhard Michael}, series = {Biomedizinische Technik = Biomedical engineering. 36 (1991)}, journal = {Biomedizinische Technik = Biomedical engineering. 36 (1991)}, isbn = {0013-5585}, pages = {228 -- 230}, year = {1991}, language = {de} } @article{MaggakisKelemenBorkKayseretal.2003, author = {Maggakis-Kelemen, C. and Bork, M. and Kayser, Peter and Biselli, Manfred and Artmann, Gerhard}, title = {Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells}, series = {Medical and biological engineering and computing. 41 (2003), H. 3}, journal = {Medical and biological engineering and computing. 41 (2003), H. 3}, isbn = {0140-0118}, pages = {350 -- 356}, year = {2003}, language = {en} } @article{ArtmannHueckRossiteretal.2008, author = {Artmann, Gerhard and Hueck, Isgard S. and Rossiter, Katharine and Schmid-Sch{\"o}nbein, Geert W.}, title = {Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen / Hueck, Isgard S. ; Rossiter, Katharine ; Artman, Gerhard M. ; Schmid-Sch{\"o}nbein, Geert W.}, series = {Microcirculation. 15 (2008), H. 6}, journal = {Microcirculation. 15 (2008), H. 6}, isbn = {1549-8719}, pages = {531 -- 542}, year = {2008}, language = {en} } @book{Artmann2008, author = {Artmann, Gerhard}, title = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-75408-4}, year = {2008}, language = {en} } @article{ArtmannZerlinDigel2008, author = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya}, title = {Hemoglobin Senses Body Temperature}, series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, journal = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-75408-4}, pages = {415 -- 447}, year = {2008}, language = {en} } @article{KaulKoshkaryevArtmannetal.2008, author = {Kaul, D. K. and Koshkaryev, A. and Artmann, Gerhard and Barshtein, G. and Yedgar, S.}, title = {Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistance}, series = {American Journal of Physiology : Heart and Circulation Physiology . 295 (2008), H. 4}, volume = {295}, journal = {American Journal of Physiology : Heart and Circulation Physiology . 295 (2008), H. 4}, number = {4}, issn = {1522-1539}, pages = {H1788 -- H1793}, year = {2008}, language = {en} } @article{StadlerDigelArtmannetal.2008, author = {Stadler, A. M. and Digel, Ilya and Artmann, Gerhard and Embs, Jan P. and Zaccai, Joe and B{\"u}ldt, Georg}, title = {Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature}, series = {Biophysical Journal. 95 (2008), H. 11}, journal = {Biophysical Journal. 95 (2008), H. 11}, isbn = {1542-0086}, pages = {5449 -- 5461}, year = {2008}, language = {en} } @article{StadlerGarveyBocahutetal.2012, author = {Stadler, Andreas M. and Garvey, G. J. and Bocahut, A. and Sacquin-Mora, S. and Digel, Ilya and Schneider, G. J. and Natali, F. and Artmann, Gerhard and Zaccai, G.}, title = {Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics}, series = {Journal of the Royal Society Interface}, volume = {9}, journal = {Journal of the Royal Society Interface}, number = {76}, publisher = {The Royal Society}, address = {London}, issn = {1742-5689}, doi = {10.1098/rsif.2012.0364}, pages = {2845 -- 2855}, year = {2012}, abstract = {Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 {\AA} at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.}, language = {en} } @article{BeckerWallangArtmannetal.2008, author = {Becker, C. and Wallang, C. and Artmann, Gerhard and Jakse, G.}, title = {Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis}, series = {International Journal of Artificial Organs, The}, volume = {31}, journal = {International Journal of Artificial Organs, The}, number = {7}, issn = {0391-3988}, pages = {583 -- 583}, year = {2008}, language = {en} } @article{BorkKelemenBisellietal.2000, author = {Bork, M. and Kelemen, C. and Biselli, Manfred and Artmann, Gerhard}, title = {Biophysikalische Charakterisierung ex vivo kultivierter menschlicher Erythrozythen}, series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, journal = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, isbn = {1862-278X}, pages = {471 -- 472}, year = {2000}, language = {de} } @article{ArtmannStacheKoenigsfeld2000, author = {Artmann, Gerhard and Stache, O. and K{\"o}nigsfeld, J.}, title = {Temperaturabh{\"a}ngigkeit der Pseudopodienbildung und R{\"u}ckbildung von Granulozyten / Stache, O. ; K{\"o}nigsfeld, J. ; Artmann, G. M.}, series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, journal = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, isbn = {1862-278X}, pages = {450 -- 451}, year = {2000}, language = {de} } @article{ArtmannTrzewikSchmidSchoenbein2000, author = {Artmann, Gerhard and Trzewik, J. and Schmid-Sch{\"o}nbein, G. W.}, title = {Investigation on lymphatic endothelial microvalves / Trzewik, J. ; Artmann, G. M. ; Schmid-Sch{\"o}nbein, G. W.}, series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, journal = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, isbn = {1862-278X}, pages = {521 -- 522}, year = {2000}, language = {en} } @article{ArtmannVogelZinketal.2000, author = {Artmann, Gerhard and Vogel, A. and Zink, S. and Stache, O.}, title = {Entwicklung eines automatisierten, computergesteuerten Permeabilit{\"a}tsanalysators zur Messung an Endothelzellen / Vogel, A. ; Zinke, S. ; Stache, O. ; K{\"o}nigsfeld, J. ; Artmann, G.}, series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, journal = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, isbn = {1862-278X}, pages = {479 -- 480}, year = {2000}, language = {de} } @article{Artmann2000, author = {Artmann, Gerhard}, title = {Cellular engineering - a challenge for engineers? / Artmann, G. M.}, series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, journal = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, isbn = {1862-278X}, pages = {449}, year = {2000}, language = {en} } @article{ArtmannKelemenPorstetal.1998, author = {Artmann, Gerhard and Kelemen, C. and Porst, Dariusz and B{\"u}ldt, G.}, title = {Cellular engineering: Crash tests an menschlichen Erythrozyten geben Aufschluß {\"u}ber versteckte Materialeigenschaften zellul{\"a}rer Proteine / Artmann, G. M. ; Kelemen, Ch. ; Porst, D. ; B{\"u}ldt, G. ; Chien, Shu}, series = {Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1}, journal = {Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1}, isbn = {1862-278}, pages = {446 -- 447}, year = {1998}, language = {en} } @article{EijckDemmelArtmannetal.2011, author = {Eijck, Lambert van and Demmel, Franz and Artmann, Gerhard and Stadtler, Andreas Maximilian}, title = {Macromolecular dynamics in red blood cells investigated using neutron spectroscopy}, series = {Journal of the Royal Society Interface}, volume = {8}, journal = {Journal of the Royal Society Interface}, number = {57}, publisher = {The Royal Society}, address = {London}, isbn = {1742-5689}, pages = {590 -- 600}, year = {2011}, language = {en} } @book{Artmann2011, author = {Artmann, Gerhard}, title = {Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-642-11864-7}, pages = {XLI, 541 S. : Ill., graph. Darst.}, year = {2011}, language = {en} } @article{StadlerDigelEmbsetal.2009, author = {Stadler, Andreas M. and Digel, Ilya and Embs, Jan P. and Unruh, Tobias and Tehei, M. and Zaccai, G. and B{\"u}ldt, G. and Artmann, Gerhard}, title = {From powder to solution : Hydration dependence of human hemoglobin dynamics correlated to body temperature}, series = {Biophysical Journal. 96 (2009), H. 12}, journal = {Biophysical Journal. 96 (2009), H. 12}, publisher = {Cell Press}, address = {Cambridge, Mass.}, isbn = {0006-3495}, pages = {5073 -- 5081}, year = {2009}, language = {en} } @article{StadlerEmbsDigeletal.2008, author = {Stadler, Andreas M. and Embs, Jan P. and Digel, Ilya and Artmann, Gerhard and Unruh, Tobias and B{\"u}ldt, Georg and Zaccai, Guiseppe}, title = {Cytoplasmic water and hydration layer dynamics in human red blood cells}, series = {Journal of the American Chemical Society. 50 (2008), H. 130}, journal = {Journal of the American Chemical Society. 50 (2008), H. 130}, isbn = {1520-5126}, pages = {16852 -- 16853}, year = {2008}, language = {en} } @article{DigelKayserArtmann2008, author = {Digel, Ilya and Kayser, Peter and Artmann, Gerhard}, title = {Molecular processes in biological thermosensation}, series = {Journal of Biophysics. 2008 (2008)}, journal = {Journal of Biophysics. 2008 (2008)}, isbn = {1687-8000}, pages = {1 -- 9}, year = {2008}, language = {en} } @article{ZerlinDigelStadleretal.2007, author = {Zerlin, Kay and Digel, Ilya and Stadler, Andreas M. and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard}, title = {Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions}, series = {Regenerative medicine. 2 (2007), H. 5}, journal = {Regenerative medicine. 2 (2007), H. 5}, isbn = {1746-0751}, pages = {573 -- 573}, year = {2007}, language = {en} } @article{MaggakisKelemenDigelArtmann2005, author = {Maggakis-Kelemen, Christina and Digel, Ilya and Artmann, Gerhard}, title = {Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility}, series = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1}, journal = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1}, pages = {324 -- 326}, year = {2005}, language = {en} } @article{StadlerZerlinDigeletal.2008, author = {Stadler, Andreas M. and Zerlin, Kay and Digel, Ilya and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard}, title = {Dynamics and interactions of hemoglobin in red blood cells}, series = {Tissue Engineering Part A. 14 (2008), H. 5}, journal = {Tissue Engineering Part A. 14 (2008), H. 5}, isbn = {1937-3341}, pages = {724 -- 724}, year = {2008}, language = {en} } @article{ArtmannDigelLinderetal.2008, author = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Porst, Dariusz}, title = {Mechanism of haemoglobin sensing body temperature}, series = {Tissue Engineering Part A. 14 (2008), H. 5}, journal = {Tissue Engineering Part A. 14 (2008), H. 5}, isbn = {1937-3341}, pages = {754 -- 754}, year = {2008}, language = {en} } @article{ArtmannZerlinDigeletal.2007, author = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.}, title = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA}, series = {Tissue Engineering. 13 (2007), H. 7}, journal = {Tissue Engineering. 13 (2007), H. 7}, isbn = {1076-3279}, pages = {1778 -- 1778}, year = {2007}, language = {en} } @article{DigelZhubanovaNojimaetal.2004, author = {Digel, Ilya and Zhubanova, Azhar A. and Nojima, H. and Artmann, Gerhard}, title = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology}, series = {Biotechnologija : teorija i praktika (2004)}, journal = {Biotechnologija : teorija i praktika (2004)}, isbn = {1028-9399}, pages = {46 -- 52}, year = {2004}, language = {en} } @article{DigelDachwaldArtmannetal.2009, author = {Digel, Ilya and Dachwald, Bernd and Artmann, Gerhard and Linder, Peter and Funke, O.}, title = {A concept of a probe for particle analysis and life detection in icy environments}, pages = {1 -- 24}, year = {2009}, language = {en} } @article{ArtmannZang1990, author = {Artmann, Gerhard and Zang, Werner}, title = {Vollautomatische Messung rheologischer Parameter roter Blutzellen}, series = {Biomedizinische Technik / Biomedical Engineering}, volume = {35}, journal = {Biomedizinische Technik / Biomedical Engineering}, number = {S3}, issn = {0013-5585}, pages = {94 -- 96}, year = {1990}, language = {de} } @article{StadlerGarveyEmbsetal.2014, author = {Stadler, Alexander Maximilian and Garvey, Christopher J. and Embs, Jan Peter and Koza, Michael Marek and Unruh, Tobias and Artmann, Gerhard and Zaccai, Guiseppe}, title = {Picosecond dynamics in haemoglobin from different species: A quasielastic neutron scattering study}, series = {Biochimica et biophysica acta (BBA): General Subjects}, volume = {1840}, journal = {Biochimica et biophysica acta (BBA): General Subjects}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-8006 (E-Journal); 0304-4165 (Print)}, doi = {10.1016/j.bbagen.2014.06.007}, pages = {2989 -- 2999}, year = {2014}, language = {en} } @article{KowalskiLinderZierkeetal.2016, author = {Kowalski, Julia and Linder, Peter and Zierke, S. and Wulfen, B. van and Clemens, J. and Konstantinidis, K. and Ameres, G. and Hoffmann, R. and Mikucki, J. and Tulaczyk, S. and Funke, O. and Blandfort, D. and Espe, Clemens and Feldmann, Marco and Francke, Gero and Hiecker, S. and Plescher, Engelbert and Sch{\"o}ngarth, Sarah and Dachwald, Bernd and Digel, Ilya and Artmann, Gerhard and Eliseev, D. and Heinen, D. and Scholz, F. and Wiebusch, C. and Macht, S. and Bestmann, U. and Reineking, T. and Zetzsche, C. and Schill, K. and F{\"o}rstner, R. and Niedermeier, H. and Szumski, A. and Eissfeller, B. and Naumann, U. and Helbing, K.}, title = {Navigation technology for exploration of glacier ice with maneuverable melting probes}, series = {Cold Regions Science and Technology}, journal = {Cold Regions Science and Technology}, number = {123}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0165-232X}, doi = {10.1016/j.coldregions.2015.11.006}, pages = {53 -- 70}, year = {2016}, abstract = {The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.}, language = {en} } @inproceedings{SchlemmerPorstBassametal.2017, author = {Schlemmer, Katharina and Porst, Dariusz and Bassam, Rasha and Artmann, Gerhard and Digel, Ilya}, title = {Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {100 -- 101}, year = {2017}, language = {en} } @phdthesis{Artmann1988, author = {Artmann, Gerhard}, title = {Monolayer-Photometrie zur Quantifizierung der Form und induzierter Formver{\"a}nderungen menschlicher Erythrozyten}, pages = {143 S. : Ill., graph. Darst.}, year = {1988}, language = {de} } @phdthesis{Artmann1999, author = {Artmann, Gerhard}, title = {Methodische und experimentelle Beitr{\"a}ge zur Analyse der Ruheform, der Verformung und der Integrit{\"a}t humaner Erythrozyten}, pages = {144 S. : Ill., graph. Darst.}, year = {1999}, language = {de} } @misc{ArtmannLinderBayeretal.2017, author = {Artmann, Gerhard and Linder, Peter and Bayer, Robin and Gossmann, Matthias}, title = {Celldrum electrode arrangement for measuring mechanical stress [Patent of invention]}, publisher = {WIPO}, address = {Geneva}, pages = {18 Seiten}, year = {2017}, abstract = {The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance.}, language = {en} } @incollection{AzatKerimkulovaMansurovetal.2020, author = {Azat, Seitkhan and Kerimkulova, Almagul R. and Mansurov, Zulkhair A. and Adekenov, Sergazy and Artmann, Gerhard}, title = {The Use of Fusicoccin as Anticancer Compound}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing}, address = {New York}, isbn = {978-0-429-42864-7}, doi = {10.1201/9780429428647-8}, pages = {149 -- 172}, year = {2020}, abstract = {The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.}, language = {en} } @techreport{Artmann2011, author = {Artmann, Gerhard}, title = {HPBioforce: Integrierte und automatisierte Screening Plattform eines 96-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an einige um dicken Zell- und Gewebeschichten f{\"u}r die Arzneimittelforschung : gemeinsamer Abschlussbericht der FH Aachen, Hitec Zang GmbH, IKFE Mainz, IKFE Berlin und der Dr. Gerhard Schmidt GmbH zum InnoNet-Projekt ... ; Programm "F{\"o}rderung von innovativen Netzwerken" (InnoNet) des Bundesministerium f{\"u}r Wirtschaft und Technologie (BMWi) ; Laufzeit: 01.05.2007 bis 31.12.2010}, publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek}, address = {Aachen [u.a.]}, doi = {10.2314/GBV:68757076X}, year = {2011}, language = {de} } @techreport{Artmann2011, author = {Artmann, Gerhard}, title = {FhprofUnd EasyBioforce Abschlussbericht : Miniaturisierte, integrierte und automatisierte Screening Plattform eines 36-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an Zell- und Gewebeschichten f{\"u}r die Arzneimittelforschung : Laufzeit des Vorhabens: 01.03.2007 - 31.12.2010}, publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek}, address = {Aachen}, doi = {10.2314/GBV:782964621}, year = {2011}, language = {de} } @techreport{Artmann2004, author = {Artmann, Gerhard}, title = {Escherichia Coli Infektion und Zellsch{\"a}digung - Wie perfekt wirken Antibiotika? : Abschlussbericht zum Projekt 1703701}, publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek}, address = {J{\"u}lich}, doi = {10.2314/GBV:482527137}, year = {2004}, language = {de} } @techreport{Artmann2011, author = {Artmann, Gerhard}, title = {Plant mutant scanner : Hochdurchsatzscanner zur Charakterisierung von Pflanzenmutanten. Abschlussbericht ; FHprofUnd ; PhytoScan ; Laufzeit des Vorhabens: 01.07.2008 - 30.06.2011}, publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek}, address = {Aachen}, doi = {10.2314/GBV:747569150}, year = {2011}, language = {de} } @techreport{ArtmannBaeumler2002, author = {Artmann, Gerhard and B{\"a}umler, H.}, title = {Pharmamikrocontainer mit designgesteuerter Permeabilit{\"a}t als Transporter f{\"u}r ausgew{\"a}hlte Pharmaka. Ein Gemeinschaftsprojekt im Forschungsschwerpunkt "Celluar Engineering" [Laufzeit: 01.09.2000 - 28.02.2002]}, publisher = {FH Aachen}, address = {J{\"u}lich}, year = {2002}, language = {de} }