@article{StreeseKotliarDeiserothetal.2020, author = {Streese, Lukas and Kotliar, Konstantin and Deiseroth, Arne and Infanger, Denis and Gugleta, Konstantin and Schmaderer, Christoph and Hanssen, Henner}, title = {Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial}, series = {Scandinavian Journal of Medicine and Science in Sports}, volume = {30}, journal = {Scandinavian Journal of Medicine and Science in Sports}, number = {2}, publisher = {Wiley}, address = {Oxford}, issn = {1600-0838}, doi = {10.1111/sms.13560}, pages = {272 -- 280}, year = {2020}, abstract = {The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1\%, post: 3.0 ± 2.2\%, P = .018) and AFarea (pre: 32.6 ± 28.4\%*s, post: 37.7 ± 30.6\%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8\%, post: 2.9 ± 1.8\%, P = .254; AFarea, pre: 41.6 ± 28.5\%*s, post: 37.8 ± 27.0\%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.}, language = {en} } @article{KotliarKoshitzSvetlowaetal.2006, author = {Kotliar, Konstantin and Koshitz, I. N. and Svetlowa, O. V. and Zaseeva, M. V.}, title = {Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar}, series = {Glaukoma (2006)}, journal = {Glaukoma (2006)}, publisher = {-}, pages = {51 -- 70}, year = {2006}, language = {en} } @article{KotliarKoshitzSvetlowaetal.2005, author = {Kotliar, Konstantin and Koshitz, I. N. and Svetlowa, O. V. and Makarov, F. N.}, title = {Biomechanical analysis of traditional and contemporary conceptions on pathogenesis of the primary open angle glaucoma / Koshitz, I. N. ; Svetlova, O. V. ; Kotliar, K. E. ; Makarov, F. N. ; Smolnikov, B. A.}, series = {Glaukoma (2005)}, journal = {Glaukoma (2005)}, publisher = {-}, pages = {41 -- 63}, year = {2005}, language = {en} } @article{KotliarSvetlovaStegaevetal.2004, author = {Kotliar, Konstantin and Svetlova, O. V. and Stegaev, V. A. and Parkhomov, S. D.}, title = {Biomechanical substantiation of relatively low efficiency of recurrent laser trabeculoplasty / Svetlova, O. V. ; Stagaev, V. A. ; Parkhomov, S. D. ; Kotliar, K. E. ; Makarov, F. N. ; Smolnikov, B. A. ; Koshitz, I. N.}, series = {Glaukoma (2004)}, journal = {Glaukoma (2004)}, publisher = {-}, pages = {29 -- 39}, year = {2004}, language = {en} } @article{KotliarSvetlovaSourjikovetal.2004, author = {Kotliar, Konstantin and Svetlova, O. V. and Sourjikov, A. V. and Zaseeva, M. V.}, title = {Biomechanical peculiarities of aqueous humor production system and outflow regulation system / Svetlova, O. V. ; Sourjikov, A. V. ; Kotliar, K. E. ; Zaseeva, M. V. ; Shukhaev, S. V. ; Koshitz, I. N.}, series = {Glaukoma (2004)}, journal = {Glaukoma (2004)}, publisher = {-}, pages = {66 -- 76}, year = {2004}, language = {en} } @phdthesis{Kotliar2008, author = {Kotliar, Konstantin}, title = {Functional in-vivo assessment and biofluidmechanical analysis of age-related and pathological microstructural changes in retinal vessels [Elektronische Ressource]}, publisher = {-}, year = {2008}, language = {en} } @phdthesis{Kotliar1998, author = {Kotliar, Konstantin}, title = {Razrabotka i analiz matematicheskih modelei nezavisimogo i svyazannogo funkcionirovaniya drenazhnoi i akkomodacionnoi regulyatornyh sistem chelovecheskogo glaza}, publisher = {-}, pages = {328 S.}, year = {1998}, language = {ru} } @article{KotliarHanssenEberhardtetal.2013, author = {Kotliar, Konstantin and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Schmaderer, Christoph and Halle, Martin and Heemann, Uwe and Baumann, M.}, title = {Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects}, series = {Microcirculation}, journal = {Microcirculation}, publisher = {Wiley}, address = {Malden}, issn = {1549-8719}, year = {2013}, language = {en} } @article{MurganBeyerKotliaretal.2013, author = {Murgan, Ilina and Beyer, Sonja and Kotliar, Konstantin and Weber, Lutz and Bechtold-Dalla Pozza, Susanne and Dalla Pozza, Robert and Wegner, Aharon and Sitnikova, Diana and Stock, Konrad and Heemann, Uwe and Schmaderer, Christoph and Baumann, M.}, title = {Arterial and Retinal Vascular Changes in Hypertensive and Prehypertensive Adolescents}, series = {American Journal of Hypertension}, volume = {26}, journal = {American Journal of Hypertension}, number = {3}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1941-7225}, pages = {400 -- 408}, year = {2013}, language = {de} } @article{FeuchtSchoenbachLanzletal.2013, author = {Feucht, Nikolaus and Sch{\"o}nbach, Etienne Michael and Lanzl, Ines and Kotliar, Konstantin and Lohmann, Chris Patrick and Maier, Mathias}, title = {Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease}, series = {Clinical Ophthalmology}, volume = {7}, journal = {Clinical Ophthalmology}, publisher = {Dove Medical Press}, address = {Auckland, New Zealand}, issn = {1177-5483}, pages = {173 -- 178}, year = {2013}, language = {en} } @article{KotliarLanzl2011, author = {Kotliar, Konstantin and Lanzl, Ines M.}, title = {Can vascular function be assessed by the interpretation of retinal vascular diameter changes?}, series = {Investigative Ophthalmology \& Visual Science, IOVS. 52 (2011), H. 1}, journal = {Investigative Ophthalmology \& Visual Science, IOVS. 52 (2011), H. 1}, publisher = {ARVO}, address = {Rockville, Md.}, isbn = {0146-0404}, pages = {635 -- 636}, year = {2011}, language = {en} } @article{KotliarMueckeVilseretal.2008, author = {Kotliar, Konstantin and M{\"u}cke, Bruno and Vilser, Walthard and Schilling, Rudolf}, title = {Effect of aging on retinal artery blood column diameter measured along the vessel axis / Kotliar, Konstantin E. ; M{\"u}cke, Bruno ; Vilser, Walthard ; Schilling, Rudolf ; Lanzl, Ines M.}, series = {Investigative Ophthalmology \& Visual Science, IOVS. 49 (2008), H. 5}, journal = {Investigative Ophthalmology \& Visual Science, IOVS. 49 (2008), H. 5}, publisher = {-}, isbn = {0146-0404}, pages = {2094 -- 2102}, year = {2008}, language = {en} } @article{KotliarLanzlHanssenetal.2012, author = {Kotliar, Konstantin and Lanzl, Ines M. and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Halle, Martin and Heemann, Uwe and Schmidt-Trucks{\"a}ss, Arno and Baumann, Marcus}, title = {Does increased blood pressure rather than aging influence retinal pulse wave velocity?}, series = {Investigative Ophthalmology \& Visual Science, IOVS}, volume = {53}, journal = {Investigative Ophthalmology \& Visual Science, IOVS}, number = {4}, publisher = {ARVO}, address = {Rockville, Md.}, issn = {0146-0404}, doi = {10.1167/iovs.11-8815}, pages = {2119 -- 2126}, year = {2012}, abstract = {Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself. Methods: A total of 12 young 25.5-year-old (24.0-28.8) [median(1st quartile-3rd quartile)] and 12 senior 68.5-year-old (63.8-71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8-65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5-35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated. Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280-500] RU/s) and in validated healthy seniors (400 [320-510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains. Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV.}, language = {en} } @article{KotliarNagelVilseretal.2010, author = {Kotliar, Konstantin and Nagel, Edgar and Vilser, Walthard and Seidova, Seid-Fatima and Lanzl, Ines}, title = {Microstructural alterations of retinal arterial blood column along the vessel axis in systemic hypertension}, series = {Investigative Ophthalmology \& Visual Science, IOVS}, volume = {51}, journal = {Investigative Ophthalmology \& Visual Science, IOVS}, number = {4}, publisher = {ARVO}, address = {Rockville, Md.}, issn = {0146-0404}, doi = {10.1167/iovs.09-3649}, pages = {2165 -- 2172}, year = {2010}, abstract = {Purpose: Image analysis by the retinal vessel analyzer (RVA) observes retinal vessels in their dynamic state online noninvasively along a chosen vessel segment. It has been found that high-frequency diameter changes in the retinal artery blood column along the vessel increase significantly in anamnestically healthy volunteers with increasing age and in patients with glaucoma during vascular dilation. This study was undertaken to investigate whether longitudinal sections of the retinal artery blood column are altered in systemic hypertension. Methods: Retinal arteries of 15 untreated patients with essential arterial hypertension (age, 50.9 ± 11.9 years) and of 15 age-matched anamnestically healthy volunteers were examined by RVA. After baseline assessment, a monochromatic luminance flicker (530-600 nm; 12.5 Hz; 20 s) was applied to evoke retinal vasodilation. Differences in amplitude and frequency of spatial artery blood column diameter change along segments (longitudinal arterial profiles) of 1 mm in length were measured and analyzed using Fourier transformation. Results: In the control group, average reduced power spectra (ARPS) of longitudinal arterial profiles did not differ when arteries changed from constriction to dilation. In the systemic hypertension group, ARPS during constriction, baseline, and restoration were identical and differed from ARPS during dilation (P < 0.05). Longitudinal arterial profiles in both groups showed significant dissimilitude at baseline and restoration (P < 0.05). Conclusions: The retinal artery blood column demonstrates microstructural alterations in systemic hypertension and is less irregular along the vessel axis during vessel dilation. These microstructural changes may be an indication of alterations in vessel wall rigidity, vascular endothelial function, and smooth muscle cells in this disease, leading to impaired perfusion and regulation.}, language = {en} } @article{KotliarVilserSchmidtTrucksaessetal.2009, author = {Kotliar, Konstantin and Vilser, W. and Schmidt-Trucks{\"a}ss, A. and Halle, M. and Lanzl, I. M.}, title = {Zeitliche Schwingungen retinaler Gef{\"a}ßdurchmesser bei Gesunden unterschiedlichen Alters : Kreuz- und Autokorrelation f{\"u}r dynamische Gef{\"a}ßanalyse}, series = {Der Ophthalmologe}, volume = {106}, journal = {Der Ophthalmologe}, number = {7}, publisher = {-}, isbn = {1433-0423}, pages = {609 -- 618}, year = {2009}, language = {de} } @article{LanzlSeidovaMaieretal.2011, author = {Lanzl, Ines M. and Seidova, Seid-Fatima and Maier, Mathias and Schmidt-Trucks{\"a}ss, Arno and Halle, Martin and Kotliar, Konstantin}, title = {Dynamic retinal vessel response to flicker in age-related macular degeneration patients before and after vascular endothelial growth factor inhibitor injection}, series = {Acta Ophthalmologica}, volume = {89}, journal = {Acta Ophthalmologica}, number = {5}, publisher = {Wiley}, address = {Weinheim}, isbn = {1755-3768}, pages = {472 -- 479}, year = {2011}, language = {en} } @article{KotliarMaierBaueretal.2008, author = {Kotliar, Konstantin and Maier, Mathias and Bauer, Svetlana and Feucht, Nikolaus and Lohmann, Chris and Lanzl, Ines}, title = {Intravitreal injection of triamcinolone acetonide and intraocular pressure: author's reply}, series = {Acta Ophthalmologica}, volume = {86}, journal = {Acta Ophthalmologica}, number = {6}, publisher = {-}, isbn = {1755-3768}, pages = {692 -- 693}, year = {2008}, language = {en} } @article{KotliarNagelVilseretal.2008, author = {Kotliar, Konstantin and Nagel, Edgar and Vilser, Walthard and Lanzl, Ines M.}, title = {Functional in vivo assessment of retinal artery microirregularities in glaucoma / Kotliar, Konstantin E. ; Nagel, Edgar ; Vilser, Walthard ; Lanzl, Ines M.}, series = {Acta Ophthalmologica. 86 (2008), H. 4}, journal = {Acta Ophthalmologica. 86 (2008), H. 4}, publisher = {-}, isbn = {1755-3768}, pages = {424 -- 433}, year = {2008}, language = {en} } @article{KotliarMaierBaueretal.2007, author = {Kotliar, Konstantin and Maier, Mathias and Bauer, Svetlana and Feucht, Nikolaus}, title = {Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model / Kotliar, Konstantin ; Maier, Mathias ; Bauer, Svetlana ; Feucht, Nikolaus ; Lohmann, Chris ; Lanzl, Ines}, series = {Acta Ophthalmologica Scandinavica. 85 (2007), H. 7}, journal = {Acta Ophthalmologica Scandinavica. 85 (2007), H. 7}, publisher = {-}, isbn = {1755-3768}, pages = {777 -- 781}, year = {2007}, language = {en} } @article{NurispahicKotliarLanzl2008, author = {Nurispahic, A. and Kotliar, Konstantin and Lanzl, I.}, title = {Messung der Akkommodation mittels optischer Biometrie}, series = {Der Ophthalmologe}, volume = {105}, journal = {Der Ophthalmologe}, number = {4}, publisher = {-}, isbn = {1433-0423}, pages = {369 -- 375}, year = {2008}, language = {de} }