@article{EmontsBuyel2023, author = {Emonts, Jessica and Buyel, Johannes Felix}, title = {An overview of descriptors to capture protein properties - Tools and perspectives in the context of QSAR modeling}, series = {Computational and Structural Biotechnology Journal}, journal = {Computational and Structural Biotechnology Journal}, number = {21}, publisher = {Research Network of Computational and Structural Biotechnology}, address = {Gotenburg}, issn = {2001-0370 (online-ressource)}, doi = {10.1016/j.csbj.2023.05.022}, pages = {3234 -- 3247}, year = {2023}, abstract = {Proteins are important ingredients in food and feed, they are the active components of many pharmaceutical products, and they are necessary, in the form of enzymes, for the success of many technical processes. However, production can be challenging, especially when using heterologous host cells such as bacteria to express and assemble recombinant mammalian proteins. The manufacturability of proteins can be hindered by low solubility, a tendency to aggregate, or inefficient purification. Tools such as in silico protein engineering and models that predict separation criteria can overcome these issues but usually require the complex shape and surface properties of proteins to be represented by a small number of quantitative numeric values known as descriptors, as similarly used to capture the features of small molecules. Here, we review the current status of protein descriptors, especially for application in quantitative structure activity relationship (QSAR) models. First, we describe the complexity of proteins and the properties that descriptors must accommodate. Then we introduce descriptors of shape and surface properties that quantify the global and local features of proteins. Finally, we highlight the current limitations of protein descriptors and propose strategies for the derivation of novel protein descriptors that are more informative.}, language = {en} } @article{KaemperDoepperEhrfeldetal.1995, author = {K{\"a}mper, Klaus-Peter and D{\"o}pper, J. and Ehrfeld, W. and Hagemann, B.}, title = {An investigation of computer modelling for micro-injection moulding. Hill, S.D.J.; K{\"a}mper, K.-P.; Dasbach, U.; D{\"o}pper, J.; Ehrfeld, W.; Kaupert, M.}, series = {Simulation and design of microsystems and microstructures : [... contains the papers presented at the First International Conference on the Simulation and Design of Microsystems and Microstructures, MicroSIM '95, which was held in Southampton, UK, in September 1995] / [organised by: Wessex Institute of Technology, UK]. Ed.: R. A. Adey}, journal = {Simulation and design of microsystems and microstructures : [... contains the papers presented at the First International Conference on the Simulation and Design of Microsystems and Microstructures, MicroSIM '95, which was held in Southampton, UK, in September 1995] / [organised by: Wessex Institute of Technology, UK]. Ed.: R. A. Adey}, publisher = {Computational Mechanics Publ.}, address = {Southampton [u.a.]}, isbn = {1-85312-390-0}, pages = {275}, year = {1995}, language = {en} } @article{Grundmann1992, author = {Grundmann, Reinhard}, title = {Allgemeines Ger{\"a}uschgesetz und spezifische Schallkenngr{\"o}ßen.}, series = {HLH - Zeitschrift f{\"u}r Heizung, L{\"u}ftung, Klimatechnik, Haustechnik. 43 (1992), H. 8}, journal = {HLH - Zeitschrift f{\"u}r Heizung, L{\"u}ftung, Klimatechnik, Haustechnik. 43 (1992), H. 8}, isbn = {0017-9906}, pages = {437 -- 440}, year = {1992}, language = {de} } @article{Wollert1998, author = {Wollert, J{\"o}rg F.}, title = {Alles automatisch : komplexes qualit{\"a}tsorientiertes Logistikmanagement durch Vollautomatisierung}, series = {Elektrotechnik f{\"u}r die Automatisierung}, volume = {Bd. 80}, journal = {Elektrotechnik f{\"u}r die Automatisierung}, number = {H. 4}, issn = {0013-581X}, pages = {196 -- 199}, year = {1998}, language = {de} } @article{Gebhardt1997, author = {Gebhardt, Andreas}, title = {Aktuelle Trends bei RP und RT}, series = {Kunststoffe, M{\"u}nchen. 87 (1997), H. 1}, journal = {Kunststoffe, M{\"u}nchen. 87 (1997), H. 1}, isbn = {0023-5563}, pages = {27 -- 30}, year = {1997}, language = {de} } @article{AbbasHedwigBalcetal.2023, author = {Abbas, Karim and Hedwig, Lukas and Balc, Nicolae and Bremen, Sebastian}, title = {Advanced FFF of PEEK: Infill strategies and material characteristics for rapid tooling}, series = {Polymers}, volume = {2023}, journal = {Polymers}, number = {15}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/polym15214293}, pages = {Artikel 4293}, year = {2023}, abstract = {Traditional vulcanization mold manufacturing is complex, costly, and under pressure due to shorter product lifecycles and diverse variations. Additive manufacturing using Fused Filament Fabrication and high-performance polymers like PEEK offer a promising future in this industry. This study assesses the compressive strength of various infill structures (honeycomb, grid, triangle, cubic, and gyroid) when considering two distinct build directions (Z, XY) to enhance PEEK's economic and resource efficiency in rapid tooling. A comparison with PETG samples shows the behavior of the infill strategies. Additionally, a proof of concept illustrates the application of a PEEK mold in vulcanization. A peak compressive strength of 135.6 MPa was attained in specimens that were 100\% solid and subjected to thermal post-treatment. This corresponds to a 20\% strength improvement in the Z direction. In terms of time and mechanical properties, the anisotropic grid and isotropic cubic infill have emerged for use in rapid tooling. Furthermore, the study highlights that reducing the layer thickness from 0.15 mm to 0.1 mm can result in a 15\% strength increase. The study unveils the successful utilization of a room-temperature FFF-printed PEEK mold in vulcanization injection molding. The parameters and infill strategies identified in this research enable the resource-efficient FFF printing of PEEK without compromising its strength properties. Using PEEK in rapid tooling allows a cost reduction of up to 70\% in tool production.}, language = {en} } @article{KaemperPicardSchuetzeetal.2006, author = {K{\"a}mper, Klaus-Peter and Picard, A. and Sch{\"u}tze, A. and Wallach, D.}, title = {Adopting the Foundry Concept of Semiconductor Fabrication on Educational Schemes and the Virtual Technology Lab (VTL). Picard, A.; K{\"a}mper, K.-P.; Sch{\"u}tze, A.; Wallach, D.; Walter, T.}, series = {Mst-News (2006)}, journal = {Mst-News (2006)}, isbn = {0948-3128}, pages = {15, 16 -- u. 35}, year = {2006}, language = {en} } @article{GebhardtSchmidtHoetteretal.2010, author = {Gebhardt, Andreas and Schmidt, Frank-Michael and H{\"o}tter, Jan-Steffen and Sokalla, Wolfgang and Sokalla, Patrick}, title = {Additive manufacturing by selective laser melting the realizer desktop machine and its application for the dental industry}, series = {Physics Procedia}, volume = {5 B}, journal = {Physics Procedia}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1875-3892}, doi = {10.1016/j.phpro.2010.08.082}, pages = {543 -- 549}, year = {2010}, abstract = {Additive Manufacturing of metal parts by Selective Laser Melting has become a powerful tool for the direct manufacturing of complex parts mainly for the aerospace and medical industry. With the introduction of its desktop machine, Realizer targeted the dental market. The contribution describes the special features of the machine, discusses details of the process and shows manufacturing results focused on metal dental devices.}, language = {en} } @article{FateriGebhardt2015, author = {Fateri, Miranda and Gebhardt, Andreas}, title = {Additive manufactured mechanical disentanglement lock}, series = {RTejournal - Forum f{\"u}r Rapid Technologie}, volume = {12}, journal = {RTejournal - Forum f{\"u}r Rapid Technologie}, publisher = {Fachhochschule Aachen}, address = {Aachen}, issn = {1614-0923}, url = {http://nbn-resolving.de/urn:nbn:de:0009-2-42147}, year = {2015}, language = {en} } @article{EnningStuetzleViereck2006, author = {Enning, Manfred and St{\"u}tzle, T. and Viereck, U.}, title = {Adaptiver Gleitschutz f{\"u}r Schienenfahrzeuge / St{\"u}tzle, T. ; Viereck, U. ; Enning, M. ; Rulka, W. ; Stribersky, A. ; Abel, D.}, series = {Innovations for Europe : VDE-Kongress 2006, 23. - 25. Oktober 2006 in Aachen / Tagungsleiter: W. Schr{\"o}ppel}, journal = {Innovations for Europe : VDE-Kongress 2006, 23. - 25. Oktober 2006 in Aachen / Tagungsleiter: W. Schr{\"o}ppel}, publisher = {VDE-Verl.}, address = {Berlin}, isbn = {3-8007-2979-2}, pages = {401 -- 406}, year = {2006}, language = {de} }