@article{BernauKnoedlerEmontsetal.2022,
  author    = {Bernau, C. R. and Kn{\"o}dler, Matthias and Emonts, Jessica and J{\"a}pel, Ronald Colin and Buyel, Johannes Felix},
  title     = {The use of predictive models to develop chromatography-based purification processes},
  series = {Frontiers in Bioengineering and Biotechnology},
  journal   = {Frontiers in Bioengineering and Biotechnology},
  number    = {10},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-4185 (online-ressource)},
  doi       = {10.3389/fbioe.2022.1009102},
  pages     = {25 Seiten},
  year      = {2022},
  abstract  = {Chromatography is the workhorse of biopharmaceutical downstream processing because it can selectively enrich a target product while removing impurities from complex feed streams. This is achieved by exploiting differences in molecular properties, such as size, charge and hydrophobicity (alone or in different combinations). Accordingly, many parameters must be tested during process development in order to maximize product purity and recovery, including resin and ligand types, conductivity, pH, gradient profiles, and the sequence of separation operations. The number of possible experimental conditions quickly becomes unmanageable. Although the range of suitable conditions can be narrowed based on experience, the time and cost of the work remain high even when using high-throughput laboratory automation. In contrast, chromatography modeling using inexpensive, parallelized computer hardware can provide expert knowledge, predicting conditions that achieve high purity and efficient recovery. The prediction of suitable conditions in silico reduces the number of empirical tests required and provides in-depth process understanding, which is recommended by regulatory authorities. In this article, we discuss the benefits and specific challenges of chromatography modeling. We describe the experimental characterization of chromatography devices and settings prior to modeling, such as the determination of column porosity. We also consider the challenges that must be overcome when models are set up and calibrated, including the cross-validation and verification of data-driven and hybrid (combined data-driven and mechanistic) models. This review will therefore support researchers intending to establish a chromatography modeling workflow in their laboratory.},
  language  = {en}
}
@inproceedings{FerreinSchifferKallweit2018,
  author    = {Ferrein, Alexander and Schiffer, Stefan and Kallweit, Stephan},
  title     = {The ROSIN Education Concept - Fostering ROS Industrial-Related Robotics Education in Europe},
  series = {ROBOT 2017: Third Iberian Robotics Conference},
  booktitle = {ROBOT 2017: Third Iberian Robotics Conference},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-70836-2},
  doi       = {10.1007/978-3-319-70836-2_31},
  pages     = {370 -- 381},
  year      = {2018},
  language  = {en}
}
@inproceedings{SchleupenEngemannBagherietal.2016,
  author    = {Schleupen, Josef and Engemann, Heiko and Bagheri, Mohsen and Kallweit, Stephan},
  title     = {The potential of SMART climbing robot combined with a weatherproof cabin for rotor blade maintenance},
  series = {17th European Conference on Composite Materials - ECCM, Munich, Germany},
  booktitle = {17th European Conference on Composite Materials - ECCM, Munich, Germany},
  pages     = {1 -- 8},
  year      = {2016},
  language  = {en}
}
@inproceedings{Wollert2012,
  author    = {Wollert, J{\"o}rg},
  title     = {The performance of UWB-communication in an industrial environment},
  series = {IEEE 1st International Symposium on Wireless Systems : (IDAACS-SWS) : Offenburg, 20-21 Sept. 2012},
  booktitle = {IEEE 1st International Symposium on Wireless Systems : (IDAACS-SWS) : Offenburg, 20-21 Sept. 2012},
  publisher = {IEEE},
  address   = {Piscataway, NJ},
  organization    = {International Symposium on Wireless Systems <1, 2012, Offenburg>},
  isbn      = {978-1-4673-4678-8},
  doi       = {10.1109/IDAACS-SWS.2012.6377639},
  pages     = {85 -- 90},
  year      = {2012},
  language  = {en}
}
@article{HanrathPlesken1984,
  author    = {Hanrath, Wilhelm and Plesken, Wilhelm},
  title     = {The lattices of six-dimensional euclidean space},
  series = {Mathematics of computation. 43 (1984), H. 168},
  journal   = {Mathematics of computation. 43 (1984), H. 168},
  isbn      = {0025-5718},
  pages     = {573 -- 587},
  year      = {1984},
  language  = {en}
}
@inproceedings{WalkLaufferRaupachDilgeretal.2004,
  author    = {Walk-Lauffer, Bernd and Raupach, Michael and Dilger, Klaus and B{\"o}hm, Stefan and Mundt, F. and Dilthey, Ulrich and Schleser, Markus},
  title     = {The interconnection between inner filaments of textile reinforcement by means of polymer modified concrete},
  series = {Proceedings of the First International Conference on Innovative Materials and Technologies for Construction and Restoration : : Lecce, June 6 - 9, 2004 / Universit{\`a} degli Studi di Lecce / ed. Antonio La Tegola. Vol. 1: Key-notes, materials, construction},
  booktitle = {Proceedings of the First International Conference on Innovative Materials and Technologies for Construction and Restoration : : Lecce, June 6 - 9, 2004 / Universit{\`a} degli Studi di Lecce / ed. Antonio La Tegola. Vol. 1: Key-notes, materials, construction},
  publisher = {Liguori},
  address   = {Napoli},
  pages     = {150 -- 159},
  year      = {2004},
  language  = {en}
}
@article{PancContiuBocanetetal.2019,
  author    = {Panc, Nicolae and Contiu, Glad and Bocanet, Vlad and Thurn, Laura and Sabau, Emilia},
  title     = {The influence of cutting technology on surface wear hardness},
  series = {Academic Journal of Manufacturing Engineering},
  volume    = {17},
  journal   = {Academic Journal of Manufacturing Engineering},
  number    = {3},
  issn      = {1583-7904},
  pages     = {205 -- 210},
  year      = {2019},
  language  = {en}
}
@article{KaemperSchmittGuentherodt1987,
  author    = {K{\"a}mper, Klaus-Peter and Schmitt, W. and G{\"u}ntherodt, G.},
  title     = {The influence of adsorbates on the spin-resolved photoemission of Ni(110). Schmitt, W.; K{\"a}mper, K.-P.; G{\"u}ntherodt, G.},
  series = {Surface Science. 189/190 (1987)},
  journal   = {Surface Science. 189/190 (1987)},
  isbn      = {0039-6028},
  pages     = {741 -- 507},
  year      = {1987},
  language  = {en}
}
@inproceedings{ShahidiPfaffEnning2017,
  author    = {Shahidi, Parham and Pfaff, Raphael and Enning, Manfred},
  title     = {The connected wagon - a concept for the integration of vehicle side sensors and actors with cyber physical representation for condition based maintenance},
  series = {First International Conference on Rail Transportation},
  booktitle = {First International Conference on Rail Transportation},
  pages     = {1 -- 8},
  year      = {2017},
  language  = {en}
}
@inproceedings{VedralWollertBudaetal.2006,
  author    = {Vedral, Andreas and Wollert, J{\"o}rg and Buda, A. and Altrock, R.},
  title     = {The capability of bluetooth for real-time transmission in automation},
  series = {Proceedings of the IASTED International Conference on Networks and Communication Systems 2006 : March 29 - 31, 2006, Chiang Mai, Thailand},
  booktitle = {Proceedings of the IASTED International Conference on Networks and Communication Systems 2006 : March 29 - 31, 2006, Chiang Mai, Thailand},
  publisher = {Acta Pr.},
  address   = {Anaheim, Calif.},
  organization    = {International Association of Science and Technology for Development},
  pages     = {168 -- 175},
  year      = {2006},
  language  = {en}
}