@article{BergSchleserDelidovichetal.2018, author = {Berg, Alexander-Karl and Schleser, Markus and Delidovich, Artem and Houben, Alexander}, title = {Ultraschallunterst{\"u}tzter Schmelzklebstoffauftrag}, series = {adh{\"a}sion KLEBEN \& DICHTEN}, volume = {Volume 62}, journal = {adh{\"a}sion KLEBEN \& DICHTEN}, number = {Issue 12}, publisher = {Springer}, doi = {10.1007/s35145-018-0089-z}, pages = {32 -- 37}, year = {2018}, language = {de} } @article{BernauKnoedlerEmontsetal.2022, author = {Bernau, C. R. and Kn{\"o}dler, Matthias and Emonts, Jessica and J{\"a}pel, Ronald Colin and Buyel, Johannes Felix}, title = {The use of predictive models to develop chromatography-based purification processes}, series = {Frontiers in Bioengineering and Biotechnology}, journal = {Frontiers in Bioengineering and Biotechnology}, number = {10}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2296-4185 (online-ressource)}, doi = {10.3389/fbioe.2022.1009102}, pages = {25 Seiten}, year = {2022}, abstract = {Chromatography is the workhorse of biopharmaceutical downstream processing because it can selectively enrich a target product while removing impurities from complex feed streams. This is achieved by exploiting differences in molecular properties, such as size, charge and hydrophobicity (alone or in different combinations). Accordingly, many parameters must be tested during process development in order to maximize product purity and recovery, including resin and ligand types, conductivity, pH, gradient profiles, and the sequence of separation operations. The number of possible experimental conditions quickly becomes unmanageable. Although the range of suitable conditions can be narrowed based on experience, the time and cost of the work remain high even when using high-throughput laboratory automation. In contrast, chromatography modeling using inexpensive, parallelized computer hardware can provide expert knowledge, predicting conditions that achieve high purity and efficient recovery. The prediction of suitable conditions in silico reduces the number of empirical tests required and provides in-depth process understanding, which is recommended by regulatory authorities. In this article, we discuss the benefits and specific challenges of chromatography modeling. We describe the experimental characterization of chromatography devices and settings prior to modeling, such as the determination of column porosity. We also consider the challenges that must be overcome when models are set up and calibrated, including the cross-validation and verification of data-driven and hybrid (combined data-driven and mechanistic) models. This review will therefore support researchers intending to establish a chromatography modeling workflow in their laboratory.}, language = {en} } @article{BraunChengDoweyetal.2021, author = {Braun, Sebastian and Cheng, Chi-Tsun and Dowey, Steve and Wollert, J{\"o}rg}, title = {Performance evaluation of skill-based order-assignment in production environments with multi-agent systems}, series = {IEEE Journal of Emerging and Selected Topics in Industrial Electronics}, journal = {IEEE Journal of Emerging and Selected Topics in Industrial Electronics}, number = {Early Access}, publisher = {IEEE}, address = {New York}, issn = {2687-9735}, doi = {10.1109/JESTIE.2021.3108524}, year = {2021}, abstract = {The fourth industrial revolution introduces disruptive technologies to production environments. One of these technologies are multi-agent systems (MASs), where agents virtualize machines. However, the agent's actual performances in production environments can hardly be estimated as most research has been focusing on isolated projects and specific scenarios. We address this gap by implementing a highly connected and configurable reference model with quantifiable key performance indicators (KPIs) for production scheduling and routing in single-piece workflows. Furthermore, we propose an algorithm to optimize the search of extrema in highly connected distributed systems. The benefits, limits, and drawbacks of MASs and their performances are evaluated extensively by event-based simulations against the introduced model, which acts as a benchmark. Even though the performance of the proposed MAS is, on average, slightly lower than the reference system, the increased flexibility allows it to find new solutions and deliver improved factory-planning outcomes. Our MAS shows an emerging behavior by using flexible production techniques to correct errors and compensate for bottlenecks. This increased flexibility offers substantial improvement potential. The general model in this paper allows the transfer of the results to estimate real systems or other models.}, language = {en} } @article{BucurLazarescuPopetal.2019, author = {Bucur, Alexandru and Lazarescu, Lucian and Pop, Grigore Marian and Achimas, Gheorghe and Gebhardt, Andreas}, title = {Tribological performance of biodegradable lubricants under different surface roughness of tools}, series = {Academic Journal of Manufacturing Engineering}, volume = {17}, journal = {Academic Journal of Manufacturing Engineering}, number = {1}, issn = {1583-7904}, pages = {172 -- 178}, year = {2019}, language = {en} } @article{CosmaKesslerGebhardtetal.2020, author = {Cosma, Cosmin and Kessler, Julia and Gebhardt, Andreas and Campbell, Ian and Balc, Nicolae}, title = {Improving the Mechanical Strength of Dental Applications and Lattice Structures SLM Processed}, series = {Materials}, volume = {13}, journal = {Materials}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {1996-1944}, doi = {10.3390/ma13040905}, pages = {1 -- 18}, year = {2020}, abstract = {To manufacture custom medical parts or scaffolds with reduced defects and high mechanical characteristics, new research on optimizing the selective laser melting (SLM) parameters are needed. In this work, a biocompatible powder, 316L stainless steel, is characterized to understand the particle size, distribution, shape and flowability. Examination revealed that the 316L particles are smooth, nearly spherical, their mean diameter is 39.09 μm and just 10\% of them hold a diameter less than 21.18 μm. SLM parameters under consideration include laser power up to 200 W, 250-1500 mm/s scanning speed, 80 μm hatch spacing, 35 μm layer thickness and a preheated platform. The effect of these on processability is evaluated. More than 100 samples are SLM-manufactured with different process parameters. The tensile results show that is possible to raise the ultimate tensile strength up to 840 MPa, adapting the SLM parameters for a stable processability, avoiding the technological defects caused by residual stress. Correlating with other recent studies on SLM technology, the tensile strength is 20\% improved. To validate the SLM parameters and conditions established, complex bioengineering applications such as dental bridges and macro-porous grafts are SLM-processed, demonstrating the potential to manufacture medical products with increased mechanical resistance made of 316L.}, language = {en} } @article{DiltheyBrandenburgSchleser2004, author = {Dilthey, Ulrich and Brandenburg, Annette and Schleser, Markus}, title = {Dispensing and application of unfilled adhesives in the micro range}, series = {Welding and cutting. 3 (2004), H. 4}, journal = {Welding and cutting. 3 (2004), H. 4}, issn = {1612-3433}, pages = {250 -- 254}, year = {2004}, language = {en} } @article{DiltheySchleserFeldmannetal.2008, author = {Dilthey, Ulrich and Schleser, Markus and Feldmann, Martin and Pak, Daniel and Geßler, Achim}, title = {Investigation of punctiform, plane and hybrid joints of textile-reinforced concrete parts}, series = {Cement and concrete composites}, volume = {Vol. 30}, journal = {Cement and concrete composites}, number = {iss. 2}, issn = {0958-9465}, pages = {82 -- 87}, year = {2008}, language = {en} } @article{DiltheySchleserGessleretal.2005, author = {Dilthey, Ulrich and Schleser, Markus and Geßler, Achim and Rettweiler, Timo and V{\"o}lling, Boris}, title = {Kleben textilbewehrter Betonbauteile}, series = {Schweissen und Schneiden : Fachzeitschrift f{\"u}r Schweißen und verwandte Verfahren. Jg. 57 (2005), Nr. 8}, journal = {Schweissen und Schneiden : Fachzeitschrift f{\"u}r Schweißen und verwandte Verfahren. Jg. 57 (2005), Nr. 8}, issn = {0036-7184}, pages = {373 -- 377}, year = {2005}, language = {de} } @article{DiltheySchleserHanischetal.2006, author = {Dilthey, Ulrich and Schleser, Markus and Hanisch, Vera and Gries, Thomas}, title = {Garnzugpr{\"u}fung polymergetr{\"a}nkter Textilien f{\"u}r die Bewehrung von Beton}, series = {Technische Textilien}, volume = {49}, journal = {Technische Textilien}, number = {1}, issn = {0323-3243}, pages = {48 -- 50}, year = {2006}, language = {de} } @article{DuesGebhardtKallweitetal.1994, author = {Dues, M. and Gebhardt, Andreas and Kallweit, Stephan and Scheffler, T. and Siekmann, H. and Uchiyama, T.}, title = {Flow Visualization in a Cavitating Flow}, series = {Proceedings of the German-Japanese Symposium on Multi-Phase Flow : Karlsruhe, Germany, August 23 - 25, 1994 / comp. by U. M{\"u}ller ...}, journal = {Proceedings of the German-Japanese Symposium on Multi-Phase Flow : Karlsruhe, Germany, August 23 - 25, 1994 / comp. by U. M{\"u}ller ...}, publisher = {Kernforschungszentrum Karlsruhe}, address = {Karlsruhe}, pages = {391 -- 402}, year = {1994}, language = {en} } @article{EichlerBalcBremenetal.2024, author = {Eichler, Fabian and Balc, Nicolae and Bremen, Sebastian and Nink, Philipp}, title = {Investigation of laser powder bed fusion parameters with respect to their influence on the thermal conductivity of 316L samples}, series = {Journal of Manufacturing and Materials Processing}, volume = {8}, journal = {Journal of Manufacturing and Materials Processing}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {2504-4494}, doi = {10.3390/jmmp8040166}, pages = {12 Seiten}, year = {2024}, abstract = {The thermal conductivity of components manufactured using Laser Powder Bed Fusion (LPBF), also called Selective Laser Melting (SLM), plays an important role in their processing. Not only does a reduced thermal conductivity cause residual stresses during the process, but it also makes subsequent processes such as the welding of LPBF components more difficult. This article uses 316L stainless steel samples to investigate whether and to what extent the thermal conductivity of specimens can be influenced by different LPBF parameters. To this end, samples are set up using different parameters, orientations, and powder conditions and measured by a heat flow meter using stationary analysis. The heat flow meter set-up used in this study achieves good reproducibility and high measurement accuracy, so that comparative measurements between the various LPBF influencing factors to be tested are possible. In summary, the series of measurements show that the residual porosity of the components has the greatest influence on conductivity. The degradation of the powder due to increased recycling also appears to be detectable. The build-up direction shows no detectable effect in the measurement series.}, language = {en} } @article{EmontsBuyel2023, author = {Emonts, Jessica and Buyel, Johannes Felix}, title = {An overview of descriptors to capture protein properties - Tools and perspectives in the context of QSAR modeling}, series = {Computational and Structural Biotechnology Journal}, journal = {Computational and Structural Biotechnology Journal}, number = {21}, publisher = {Research Network of Computational and Structural Biotechnology}, address = {Gotenburg}, issn = {2001-0370 (online-ressource)}, doi = {10.1016/j.csbj.2023.05.022}, pages = {3234 -- 3247}, year = {2023}, abstract = {Proteins are important ingredients in food and feed, they are the active components of many pharmaceutical products, and they are necessary, in the form of enzymes, for the success of many technical processes. However, production can be challenging, especially when using heterologous host cells such as bacteria to express and assemble recombinant mammalian proteins. The manufacturability of proteins can be hindered by low solubility, a tendency to aggregate, or inefficient purification. Tools such as in silico protein engineering and models that predict separation criteria can overcome these issues but usually require the complex shape and surface properties of proteins to be represented by a small number of quantitative numeric values known as descriptors, as similarly used to capture the features of small molecules. Here, we review the current status of protein descriptors, especially for application in quantitative structure activity relationship (QSAR) models. First, we describe the complexity of proteins and the properties that descriptors must accommodate. Then we introduce descriptors of shape and surface properties that quantify the global and local features of proteins. Finally, we highlight the current limitations of protein descriptors and propose strategies for the derivation of novel protein descriptors that are more informative.}, language = {en} } @article{EngelnMuellges1982, author = {Engeln-M{\"u}llges, Gisela}, title = {Entartungsbedingungen f{\"u}r Gleitfl{\"a}chennomogramme und Nomographierbarkeitsbedingungen f{\"u}r Fluchtebenennomogramme}, series = {ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift f{\"u}r Angewandte Mathematik und Mechanik}, volume = {62}, journal = {ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift f{\"u}r Angewandte Mathematik und Mechanik}, number = {2}, issn = {1521-4001}, doi = {10.1002/zamm.19820620203}, pages = {77 -- 93}, year = {1982}, language = {de} } @article{EngemannCoenenDawaretal.2021, author = {Engemann, Heiko and C{\"o}nen, Patrick and Dawar, Harshal and Du, Shengzhi and Kallweit, Stephan}, title = {A robot-assisted large-scale inspection of wind turbine blades in manufacturing using an autonomous mobile manipulator}, series = {Applied Sciences}, volume = {11}, journal = {Applied Sciences}, number = {19}, publisher = {MDPI}, address = {Basel}, issn = {2076-3417}, doi = {10.3390/app11199271}, pages = {1 -- 22}, year = {2021}, abstract = {Wind energy represents the dominant share of renewable energies. The rotor blades of a wind turbine are typically made from composite material, which withstands high forces during rotation. The huge dimensions of the rotor blades complicate the inspection processes in manufacturing. The automation of inspection processes has a great potential to increase the overall productivity and to create a consistent reliable database for each individual rotor blade. The focus of this paper is set on the process of rotor blade inspection automation by utilizing an autonomous mobile manipulator. The main innovations include a novel path planning strategy for zone-based navigation, which enables an intuitive right-hand or left-hand driving behavior in a shared human-robot workspace. In addition, we introduce a new method for surface orthogonal motion planning in connection with large-scale structures. An overall execution strategy controls the navigation and manipulation processes of the long-running inspection task. The implemented concepts are evaluated in simulation and applied in a real-use case including the tip of a rotor blade form.}, language = {en} } @article{EngemannDuKallweitetal.2020, author = {Engemann, Heiko and Du, Shengzhi and Kallweit, Stephan and C{\"o}nen, Patrick and Dawar, Harshal}, title = {OMNIVIL - an autonomous mobile manipulator for flexible production}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {24, art. no. 7249}, publisher = {MDPI}, address = {Basel}, isbn = {1424-8220}, doi = {10.3390/s20247249}, pages = {1 -- 30}, year = {2020}, language = {en} } @article{Enning1992, author = {Enning, Manfred}, title = {Kopplungen ausschalten. Technisch anspruchsvolle Regelungsverfahren vermindern Lageabweichungen bei schnell und genau arbeitenden Robotern.}, series = {Maschinenmarkt. 98 (1992), H. 46}, journal = {Maschinenmarkt. 98 (1992), H. 46}, isbn = {0341-5775}, pages = {44 -- 46}, year = {1992}, language = {de} } @article{Enning1992, author = {Enning, Manfred}, title = {Grunds{\"a}tzliche Konzepte bei Lageregelungen f{\"u}r Industrieroboter}, series = {Maschinenmarkt. 98 (1992), H. 37}, journal = {Maschinenmarkt. 98 (1992), H. 37}, isbn = {0341-5775}, year = {1992}, language = {de} } @article{Enning2008, author = {Enning, Manfred}, title = {FlexCargoRail - Ohne Diesel in die Letzte Meile}, series = {Schienenverkehr - sicher, leise, effizient : InnoTrans, Berlin 2008 / Hrsg.: Bundesministerium f{\"u}r Wirtschaft und Technologie, Referat {\"O}ffentlichkeitsarbeit}, journal = {Schienenverkehr - sicher, leise, effizient : InnoTrans, Berlin 2008 / Hrsg.: Bundesministerium f{\"u}r Wirtschaft und Technologie, Referat {\"O}ffentlichkeitsarbeit}, address = {Berlin}, pages = {49 -- 52}, year = {2008}, language = {de} } @article{Enning2008, author = {Enning, Manfred}, title = {Einzelwagenkonzept f{\"u}r die letzte Meile : „FlexCargoRail" sieht autarke Fahrten von Waggons mit Rangiergeschwindigkeit vor. Massive Effizienzgewinne locken}, series = {Deutsche Verkehrs-Zeitung : DVZ / Logistik auf der Schiene (2008)}, journal = {Deutsche Verkehrs-Zeitung : DVZ / Logistik auf der Schiene (2008)}, isbn = {0342-166X}, year = {2008}, language = {de} } @article{Enning2006, author = {Enning, Manfred}, title = {Flexcargorail - ein Fahrzeugsystem f{\"u}r effizienten Einzelwagenverkehr / Baier, Martin ; Enning, Manfred}, series = {Logistik Management. 8 (2006), H. 3}, journal = {Logistik Management. 8 (2006), H. 3}, isbn = {1436-6231}, pages = {28 -- 42}, year = {2006}, language = {de} }