@article{PancContiuBocanetetal.2019,
  author    = {Panc, Nicolae and Contiu, Glad and Bocanet, Vlad and Thurn, Laura and Sabau, Emilia},
  title     = {The influence of cutting technology on surface wear hardness},
  series = {Academic Journal of Manufacturing Engineering},
  volume    = {17},
  journal   = {Academic Journal of Manufacturing Engineering},
  number    = {3},
  issn      = {1583-7904},
  pages     = {205 -- 210},
  year      = {2019},
  language  = {en}
}
@inproceedings{LuftGebhardtBalc2019,
  author    = {Luft, Angela and Gebhardt, Andreas and Balc, Nicolae},
  title     = {Challenges of additive manufacturing in production systems},
  series = {Modern technologies in manufacturing (MTeM 2019)},
  volume    = {299},
  booktitle = {Modern technologies in manufacturing (MTeM 2019)},
  number    = {Article 01003},
  doi       = {10.1051/matecconf/201929901003},
  pages     = {6 Seiten},
  year      = {2019},
  language  = {en}
}
@book{GebhardtKesslerThurn2019,
  author    = {Gebhardt, Andreas and Kessler, Julia and Thurn, Laura},
  title     = {3D printing : understanding additive manufacturing},
  edition   = {2. Auflage},
  publisher = {Hanser},
  address   = {M{\"u}nchen},
  isbn      = {978-1-56990-702-3},
  pages     = {XVI, 204 Seiten},
  year      = {2019},
  language  = {en}
}
@inproceedings{WilbringEnningPfaffetal.2019,
  author    = {Wilbring, Daniela and Enning, Manfred and Pfaff, Raphael and Schmidt, Bernd},
  title     = {Neue Perspektiven f{\"u}r die Bahn in der Produktions- und Distributionslogistik durch Prozessautomation},
  series = {IRSA 2019: Tagungsband, Proceedings},
  booktitle = {IRSA 2019: Tagungsband, Proceedings},
  editor    = {de Doncker, Rik W. and Nießen, Nils and Schindler, Christian},
  publisher = {RWTH Aachen},
  address   = {Aachen},
  doi       = {10.18154/RWTH-2020-00014},
  pages     = {128 -- 142},
  year      = {2019},
  abstract  = {Deutschland braucht mehr Eisenbahn um CO2-Emissionen aus dem Verkehr zu reduzieren. Sie muss zum R{\"u}ckgrat aktueller Logistikprozesse, z.B. bei Kaufmannsg{\"u}tern und E-Commerce, werden. Dies geht nicht ohne neuartige betriebliche Konzepte und eine Transformation des G{\"u}terwagens von einem „dummen St{\"u}ck Stahl" zu einem modernen Werkzeug der Logistik. Als „G{\"u}terwagen 4.0" wird ein kommunikativer und kooperativer G{\"u}terwagen verstanden, der die Voraussetzung zur Automatisierung aller Prozesse der Zugvorbereitung bereitstellt, sich aber ansonsten vollkommen kompatibel mit heutigen Betriebsverfahren im Hauptlauf pr{\"a}sentiert. Durch Kommunikation zwischen G{\"u}terwagen und umgebenden intelligenten Systemen im Sinne eines „Internet der Dinge" gelingt damit unter Anderem die Realisierung hoch effizienter Gleisanschlussverkehre, die der G{\"u}terbahn neue M{\"a}rkte abseits der klassisch bahn-affinen Verkehre erschließen und letztlich den Wandel zu einer nachhaltigen G{\"u}termobilit{\"a}t f{\"o}rdern.},
  language  = {de}
}
@article{EnningSchmidtWilbring2019,
  author    = {Enning, Manfred and Schmidt, Bernd and Wilbring, Daniela},
  title     = {Auf dem Weg zur autonomen Anschlussbedienung},
  series = {Privatbahn-Magazin},
  journal   = {Privatbahn-Magazin},
  number    = {3},
  publisher = {Bahn Media},
  address   = {Suhlendorf},
  issn      = {1865-0163},
  pages     = {40 -- 43},
  year      = {2019},
  language  = {de}
}
@article{KnoedlerRuehlEmontsetal.2019,
  author    = {Kn{\"o}dler, Matthias and R{\"u}hl, Clemens and Emonts, Jessica and Buyel, Johannes Felix},
  title     = {Seasonal weather changes affect the yield and quality of recombinant proteins produced in transgenic tobacco plants in a greenhouse setting},
  series = {Frontiers in Plant Science},
  journal   = {Frontiers in Plant Science},
  number    = {10},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-462X (online-ressource)},
  doi       = {10.3389/fpls.2019.01245},
  pages     = {13 Seiten},
  year      = {2019},
  abstract  = {Transgenic plants have the potential to produce recombinant proteins on an agricultural scale, with yields of several tons per year. The cost-effectiveness of transgenic plants increases if simple cultivation facilities such as greenhouses can be used for production. In such a setting, we expressed a novel affinity ligand based on the fluorescent protein DsRed, which we used as a carrier for the linear epitope ELDKWA from the HIV-neutralizing antibody 2F5. The DsRed-2F5-epitope (DFE) fusion protein was produced in 12 consecutive batches of transgenic tobacco (Nicotiana tabacum) plants over the course of 2 years and was purified using a combination of blanching and immobilized metal-ion affinity chromatography (IMAC). The average purity after IMAC was 57 ± 26\% (n = 24) in terms of total soluble protein, but the average yield of pure DFE (12 mg kg-1) showed substantial variation (± 97 mg kg-1, n = 24) which correlated with seasonal changes. Specifically, we found that temperature peaks (>28°C) and intense illuminance (>45 klx h-1) were associated with lower DFE yields after purification, reflecting the loss of the epitope-containing C-terminus in up to 90\% of the product. Whereas the weather factors were of limited use to predict product yields of individual harvests conducted for each batch (spaced by 1 week), the average batch yields were well approximated by simple linear regression models using two independent variables for prediction (illuminance and plant age). Interestingly, accumulation levels determined by fluorescence analysis were not affected by weather conditions but positively correlated with plant age, suggesting that the product was still expressed at high levels, but the extreme conditions affected its stability, albeit still preserving the fluorophore function. The efficient production of intact recombinant proteins in plants may therefore require adequate climate control and shading in greenhouses or even cultivation in fully controlled indoor farms.},
  language  = {en}
}