@article{UmutluMaderwaldKinneretal.2013, author = {Umutlu, L. and Maderwald, S. and Kinner, S. and Kraff, O. and Bitz, Andreas and Orzada, S. and Johst, S. and Wrede, K. and Forsting, M. and Ladd, M. E. and Lauenstein, T. C. and Quick, H. H.}, title = {First-pass contrast-enhanced renal MRA at 7 Tesla: initial results}, series = {European Radiology}, volume = {23}, journal = {European Radiology}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {1432-1084}, doi = {10.1007/s00330-012-2666-0}, pages = {1059 -- 1066}, year = {2013}, language = {en} } @article{UmutluOrzadaKinneretal.2011, author = {Umutlu, Lale and Orzada, Stephan and Kinner, Sonja and Maderwald, Stefan and Bronte, Irina and Bitz, Andreas and Kraff, Oliver and Ladd, Susanne C. and Antoch, Gerald and Ladd, Mark E. and Quick, Harald H. and Lauenstein, Thomas C.}, title = {Renal imaging at 7 Tesla: preliminary results}, series = {European Radiology}, volume = {21}, journal = {European Radiology}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {1432-1084}, pages = {841 -- 849}, year = {2011}, abstract = {Objective To investigate the feasibility of 7T MR imaging of the kidneys utilising a custom-built 8-channel transmit/receive radiofrequency body coil. Methods In vivo unenhanced MR was performed in 8 healthy volunteers on a 7T whole-body MR system. After B0 shimming the following sequences were obtained: 1) 2D and 3D spoiled gradient-echo sequences (FLASH, VIBE), 2) T1-weighted 2D in and opposed phase 3) True-FISP imaging and 4) a T2-weighted turbo spin echo (TSE) sequence. Visual evaluation of the overall image quality was performed by two radiologists. Results Renal MRI at 7T was feasible in all eight subjects. Best image quality was found using T1-weighted gradient echo MRI, providing high anatomical details and excellent conspicuity of the non-enhanced vasculature. With successful shimming, B1 signal voids could be effectively reduced and/or shifted out of the region of interest in most sequence types. However, T2-weighted TSE imaging remained challenging and strongly impaired because of signal heterogeneities in three volunteers. Conclusion The results demonstrate the feasibility and diagnostic potential of dedicated 7T renal imaging. Further optimisation of imaging sequences and dedicated RF coil concepts are expected to improve the acquisition quality and ultimately provide high clinical diagnostic value.}, language = {en} } @article{HacklWegmannKahmannetal.2017, author = {Hackl, Michael and Wegmann, Kilian and Kahmann, Stephanie Lucina and Heinze, Nicolai and Staat, Manfred and Neiss, Wolfram F. and Scaal, Martin and M{\"u}ller, Lars P.}, title = {Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow}, series = {Knee Surgery, Sports Traumatology, Arthroscopy}, volume = {25}, journal = {Knee Surgery, Sports Traumatology, Arthroscopy}, number = {7}, publisher = {Springer}, address = {Berlin}, issn = {1433-7347}, doi = {10.1007/s00167-017-4468-z}, pages = {2280 -- 2288}, year = {2017}, language = {en} } @article{BalzerStreit2017, author = {Balzer, Hermann and Streit, Daniel}, title = {Das Translationsrisiko multinationaler Konzerne in Deutschland: Eine explorative Analyse von Verst{\"a}ndnis, Bedeutung und Management-Praxis mit Hilfe der Critical Incident Technique}, series = {Schmalenbachs Zeitschrift f{\"u}r betriebswirtschaftliche Forschung}, journal = {Schmalenbachs Zeitschrift f{\"u}r betriebswirtschaftliche Forschung}, number = {Online first}, publisher = {Springer}, address = {Berlin}, issn = {2366-6153}, doi = {10.1007/s41471-017-0029-x}, pages = {1 -- 40}, year = {2017}, language = {de} } @article{WiesenTippkoetterMuffleretal.2015, author = {Wiesen, Sebastian and Tippk{\"o}tter, Nils and Muffler, Kai and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland}, title = {Adsorption of fatty acids to layered double hydroxides in aqueous systems}, series = {Adsorption}, volume = {21}, journal = {Adsorption}, number = {6-7}, publisher = {Springer}, address = {Berlin}, pages = {459 -- 466}, year = {2015}, abstract = {Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L-1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32-.}, language = {en} } @article{MoraisGomesSilvaetal.2017, author = {Morais, Paulo V. and Gomes, Vanderley F., Jr. and Silva, Anielle C. A. and Dantas, Noelio O. and Sch{\"o}ning, Michael Josef and Siqueira, Jos{\´e} R., Jr.}, title = {Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices}, series = {Journal of Materials Science}, volume = {52}, journal = {Journal of Materials Science}, number = {20}, publisher = {Springer}, address = {Berlin}, issn = {1573-4803}, doi = {10.1007/s10853-017-1369-y}, pages = {12314 -- 12325}, year = {2017}, abstract = {The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance-voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film's surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications.}, language = {en} } @incollection{PoghossianSchoening2017, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Nanomaterial-Modified Capacitive Field-Effect Biosensors}, series = {Springer Series on Chemical Sensors and Biosensors (Methods and Applications)}, booktitle = {Springer Series on Chemical Sensors and Biosensors (Methods and Applications)}, publisher = {Springer}, address = {Berlin, Heidelberg}, doi = {10.1007/5346_2017_2}, pages = {1 -- 25}, year = {2017}, abstract = {The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte-insulator-semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing.}, language = {en} } @incollection{TranTranMatthiesetal.2017, author = {Tran, N. T. and Tran, Thanh Ngoc and Matthies, M. G. and Stavroulakis, G. E. and Staat, Manfred}, title = {Shakedown Analysis Under Stochastic Uncertainty by Chance Constrained Programming}, series = {Advances in Direct Methods for Materials and Structures}, booktitle = {Advances in Direct Methods for Materials and Structures}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-59810-9}, doi = {10.1007/978-3-319-59810-9_6}, pages = {85 -- 103}, year = {2017}, abstract = {In this paper we propose a stochastic programming method to analyse limit and shakedown of structures under uncertainty condition of strength. Based on the duality theory, the shakedown load multiplier formulated by the kinematic theorem is proved actually to be the dual form of the shakedown load multiplier formulated by static theorem. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) with three-node linear triangular elements is used for structural analysis.}, language = {en} } @inproceedings{EngemannWiesenKallweitetal.2018, author = {Engemann, Heiko and Wiesen, Patrick and Kallweit, Stephan and Deshpande, Harshavardhan and Schleupen, Josef}, title = {Autonomous mobile manipulation using ROS}, series = {Advances in Service and Industrial Robotics}, booktitle = {Advances in Service and Industrial Robotics}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-61276-8}, doi = {10.1007/978-3-319-61276-8_43}, pages = {389 -- 401}, year = {2018}, language = {en} } @article{RoehlenPilasSchoeningetal.2017, author = {R{\"o}hlen, Desiree and Pilas, Johanna and Sch{\"o}ning, Michael Josef and Selmer, Thorsten}, title = {Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid}, series = {Applied Biochemistry and Biotechnology}, volume = {183}, journal = {Applied Biochemistry and Biotechnology}, publisher = {Springer}, address = {Berlin}, issn = {1559-0291}, doi = {10.1007/s12010-017-2578-1}, pages = {566 -- 581}, year = {2017}, abstract = {Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM-1 (L-malate biosensor) and 0.4 μA mM-1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0-10.0 mM with a sensitivity of 0.09 μA mM-1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates.}, language = {en} } @article{SrivastavaChaharSharmaetal.2017, author = {Srivastava, A. and Chahar, V. and Sharma, V. and Sun, Y. and Bol, R. and Knolle, F. and Schnug, E. and Hoyler, Friedrich and Naskar, N. and Lahiri, S. and Patnaik, R.}, title = {Study of uranium toxicity using low-background gamma-ray spectrometry}, series = {Journal of Radioanalytical and Nuclear Chemistry}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, number = {Online first}, publisher = {Springer}, address = {Berlin}, issn = {1588-2780}, doi = {10.1007/s10967-017-5466-9}, pages = {1 -- 7}, year = {2017}, language = {en} } @incollection{MufflerTippkoetterUlber2010, author = {Muffler, Kai and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Chemical feedstocks and fine chemicals from other substrates}, series = {Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference)}, booktitle = {Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference)}, editor = {Timmis, Kenneth N.}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-540-77588-1}, doi = {10.1007\%2F978-3-540-77587-4_214}, pages = {2891 -- 2902}, year = {2010}, language = {en} } @article{TippkoetterStueckmannKrolletal.2009, author = {Tippk{\"o}tter, Nils and St{\"u}ckmann, Henning and Kroll, Stephen and Winkelmann, Gunda and Noack, Udo and Scheper, Thomas and Ulber, Roland}, title = {A semi-quantitative dipstick assay for microcystin}, series = {Analytical and Bioanalytical Chemistry}, volume = {394}, journal = {Analytical and Bioanalytical Chemistry}, number = {3}, publisher = {springer}, address = {Berlin}, issn = {1618-2650}, doi = {10.1007/s00216-009-2750-8}, pages = {863 -- 869}, year = {2009}, abstract = {An immunochromatographic lateral flow dipstick assay for the fast detection of microcystin-LR was developed. Colloid gold particles with diameters of 40 nm were used as red-colored antibody labels for the visual detection of the antigen. The new dipstick sensor is capable of detecting down to 5 µg·l-1 (ppb; total inversion of the color signal) or 1 ppb (observation of color grading) of microcystin-LR. The course of the labeling reaction was observed via spectrometric wave shifts caused by the change of particle size during the binding of antibodies. Different stabilizing reagents showed that especially bovine serum albumin (BSA) and casein increase the assays sensitivity and the conjugate stability. Performance of the dipsticks was quantified by pattern processing of capture zone CCD images. Storage stability of dipsticks and conjugate suspensions over 115 days under different conditions were monitored. The ready-to-use dipsticks were successfully tested with microcystin-LR-spiked samples of outdoor drinking- and salt water and applied to the tissue of microcystin-fed mussels.}, language = {en} } @article{GaribaldiBegingCaneseetal.2017, author = {Garibaldi, F. and Beging, Stefan and Canese, R. and Carpinelli, G. and Clinthorne, N. and Colilli, S. and Cosentino, L. and Finocchiaro, P. and Giuliani, F. and Gricia, M. and Lucentini, M. and Majewski, S. and Monno, E. and Musico, P. and Santavenere, F. and T{\"o}dter, J. and Wegener, Hans-Peter and Ziemons, Karl}, title = {A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer}, series = {European Physical Journal Plus}, volume = {132}, journal = {European Physical Journal Plus}, number = {9}, publisher = {Springer}, address = {Berlin}, issn = {2190-5444}, doi = {10.1140/epjp/i2017-11662-x}, year = {2017}, language = {en} } @article{BalzerStreitHeinze2017, author = {Balzer, Hermann and Streit, Daniel and Heinze, Marcel}, title = {Implikationen der Digitalisierung f{\"u}r den Finanzbereich der Unternehmung und das Rollenbild des CFO}, series = {Betriebswirtschaftliche Implikationen der digitalen Transformation. ZfbF - Schmalenbachs Zeitschrift f{\"u}r betriebswirtschaftliche Forschung, Sonderheft 72}, journal = {Betriebswirtschaftliche Implikationen der digitalen Transformation. ZfbF - Schmalenbachs Zeitschrift f{\"u}r betriebswirtschaftliche Forschung, Sonderheft 72}, number = {72}, editor = {Krause, Stefan}, publisher = {Springer}, address = {Berlin}, doi = {10.1007/978-3-658-18751-4_14}, pages = {267 -- 283}, year = {2017}, language = {de} } @article{FerreinSteinbauer2016, author = {Ferrein, Alexander and Steinbauer, Gerald}, title = {The Interplay of Aldebaran and RoboCup}, series = {KI - K{\"u}nstliche Intelligenz}, volume = {30}, journal = {KI - K{\"u}nstliche Intelligenz}, number = {3-4}, publisher = {Springer}, address = {Berlin}, issn = {1610-1987}, doi = {10.1007/s13218-016-0440-1}, pages = {325 -- 326}, year = {2016}, language = {en} } @article{SteinbauerFerrein2016, author = {Steinbauer, Gerald and Ferrein, Alexander}, title = {20 Years of RoboCup}, series = {KI - K{\"u}nstliche Intelligenz}, volume = {30}, journal = {KI - K{\"u}nstliche Intelligenz}, number = {3-4}, publisher = {Springer}, address = {Berlin}, issn = {1610-1987}, doi = {10.1007/s13218-016-0442-z}, pages = {221 -- 224}, year = {2016}, language = {en} } @article{FerreinSteinbauer2016, author = {Ferrein, Alexander and Steinbauer, Gerald}, title = {Looking back on 20 Years of RoboCup}, series = {KI - K{\"u}nstliche Intelligenz}, volume = {30}, journal = {KI - K{\"u}nstliche Intelligenz}, number = {3-4}, publisher = {Springer}, address = {Berlin}, issn = {1610-1987}, doi = {10.1007/s13218-016-0443-y}, pages = {321 -- 323}, year = {2016}, language = {en} } @incollection{NiemuellerZwillingLakemeyeretal.2017, author = {Niemueller, Tim and Zwilling, Frederik and Lakemeyer, Gerhard and L{\"o}bach, Matthias and Reuter, Sebastian and Jeschke, Sabina and Ferrein, Alexander}, title = {Cyber-Physical System Intelligence}, series = {Industrial Internet of Things}, booktitle = {Industrial Internet of Things}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-42559-7}, doi = {10.1007/978-3-319-42559-7_17}, pages = {447 -- 472}, year = {2017}, abstract = {Cyber-physical systems are ever more common in manufacturing industries. Increasing their autonomy has been declared an explicit goal, for example, as part of the Industry 4.0 vision. To achieve this system intelligence, principled and software-driven methods are required to analyze sensing data, make goal-directed decisions, and eventually execute and monitor chosen tasks. In this chapter, we present a number of knowledge-based approaches to these problems and case studies with in-depth evaluation results of several different implementations for groups of autonomous mobile robots performing in-house logistics in a smart factory. We focus on knowledge-based systems because besides providing expressive languages and capable reasoning techniques, they also allow for explaining how a particular sequence of actions came about, for example, in the case of a failure.}, language = {en} } @incollection{BhattaraiFrotscherStaat2018, author = {Bhattarai, Aroj and Frotscher, Ralf and Staat, Manfred}, title = {Computational Analysis of Pelvic Floor Dysfunction}, series = {Women's Health and Biomechanics}, booktitle = {Women's Health and Biomechanics}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-71574-2}, doi = {10.1007/978-3-319-71574-2_17}, pages = {217 -- 230}, year = {2018}, abstract = {Pelvic floor dysfunction (PFD) is characterized by the failure of the levator ani (LA) muscle to maintain the pelvic hiatus, resulting in the descent of the pelvic organs below the pubococcygeal line. This chapter adopts the modified Humphrey material model to consider the effect of the muscle fiber on passive stretching of the LA muscle. The deformation of the LA muscle subjected to intra-abdominal pressure during Valsalva maneuver is compared with the magnetic resonance imaging (MRI) examination of a nulliparous female. Numerical result shows that the fiber-based Humphrey model simulates the muscle behavior better than isotropic constitutive models. Greater posterior movement of the LA muscle widens the levator hiatus due to lack of support from the anococcygeal ligament and the perineal structure as a consequence of birth-related injury and aging. Old and multiparous females with uncontrolled urogenital and rectal hiatus tend to develop PFDs such as prolapse and incontinence.}, language = {en} } @article{KerpenBungValeroetal.2017, author = {Kerpen, Nils B. and Bung, Daniel B. and Valero, Daniel and Schlurmann, Torsten}, title = {Energy dissipation within the wave run-up at stepped revetments}, series = {Journal of Ocean University of China}, volume = {16}, journal = {Journal of Ocean University of China}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {1993-5021}, doi = {10.1007/s11802-017-3355-z}, pages = {649 -- 654}, year = {2017}, language = {en} } @article{WeiheErnstRoethetal.2013, author = {Weihe, Stefan and Ernst, Ansgar and R{\"o}th, Thilo and Proksch, Johannes}, title = {Aluminium-Stahl-Verbundguss im Nutzfahrzeugbau}, series = {ATZ - Automobiltechnische Zeitschrift}, volume = {115}, journal = {ATZ - Automobiltechnische Zeitschrift}, number = {4}, publisher = {Springer Fachmedien Wiesbaden}, issn = {2192-8800 (Online)}, pages = {312 -- 316}, year = {2013}, abstract = {In modernen Fahrzeugkarosserien der Großserie kommen zunehmend Materialmischbauweisen zur Anwendung. In Zusammenarbeit der Daimler AG, der Tower Automotive Holding GmbH, der Imperia GmbH sowie der Partnerunternehmen KSM Castings GmbH und Schaufler Tooling GmbH \& Co. KG wird das Leichtbaupotenzial von Aluminiumverbundguss-Stahlblech-Hybriden am Beispiel des vorderen Dachquertr{\"a}gers des Mercedes-Benz Viano/Vito ausf{\"u}hrlich untersucht.}, language = {de} } @incollection{BhattaraiStaat2018, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Mechanics of soft tissue reactions to textile mesh implants}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_11}, pages = {251 -- 275}, year = {2018}, abstract = {For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment.}, language = {en} } @incollection{ArtmannMeruvuKizildagetal.2018, author = {Artmann, Gerhard and Meruvu, Haritha and Kizildag, Sefa and Temiz Artmann, Ayseg{\"u}l}, title = {Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_7}, pages = {157 -- 192}, year = {2018}, abstract = {Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative "CellDrum technology" was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.}, language = {en} } @incollection{DuongSeifarthTemizArtmannetal.2018, author = {Duong, Minh Tuan and Seifarth, Volker and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Staat, Manfred}, title = {Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_9}, pages = {209 -- 232}, year = {2018}, abstract = {Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.}, language = {en} } @incollection{FrotscherStaat2018, author = {Frotscher, Ralf and Staat, Manfred}, title = {Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_10}, pages = {233 -- 250}, year = {2018}, abstract = {Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.}, language = {en} } @incollection{DigelAkimbekovKistaubayevaetal.2018, author = {Digel, Ilya and Akimbekov, Nuraly Sh. and Kistaubayeva, Aida and Zhubanova, Azhar A.}, title = {Microbial Sampling from Dry Surfaces: Current Challenges and Solutions}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_19}, pages = {421 -- 456}, year = {2018}, abstract = {Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms' recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling.}, language = {en} } @incollection{WagemannTippkoetter2019, author = {Wagemann, Kurt and Tippk{\"o}tter, Nils}, title = {Biorefineries: a short introduction}, series = {Biorefineries}, booktitle = {Biorefineries}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-97117-9}, doi = {10.1007/10_2017_4}, pages = {1 -- 11}, year = {2019}, abstract = {The terms bioeconomy and biorefineries are used for a variety of processes and developments. This short introduction is intended to provide a delimitation and clarification of the terminology as well as a classification of current biorefinery concepts. The basic process diagrams of the most important biorefinery types are shown.}, language = {en} } @article{Dikta2017, author = {Dikta, Gerhard}, title = {Semi-parametric random censorship models}, series = {From Statistics to Mathematical Finance : Festschrift in Honour of Winfried Stute}, journal = {From Statistics to Mathematical Finance : Festschrift in Honour of Winfried Stute}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-319-50986-0}, doi = {10.1007/978-3-319-50986-0_3}, pages = {43 -- 56}, year = {2017}, language = {en} } @article{KunkelGebhardtMpofuetal.2018, author = {Kunkel, Maximilian Hugo and Gebhardt, Andreas and Mpofu, Khumbaulani and Kallweit, Stephan}, title = {Statistical assessment of mechanical properties of selective laser melted specimens of stainless steel}, series = {The International Journal of Advanced Manufacturing Technology}, volume = {98}, journal = {The International Journal of Advanced Manufacturing Technology}, number = {5-8}, publisher = {Springer}, address = {London}, issn = {0268-3768}, doi = {10.1007/s00170-018-2040-8}, pages = {1409 -- 1431}, year = {2018}, abstract = {The rail business is challenged by long product life cycles and a broad spectrum of assembly groups and single parts. When spare part obsolescence occurs, quick solutions are needed. A reproduction of obsolete parts is often connected to long waiting times and minimum lot quantities that need to be purchased and stored. Spare part storage is therefore challenged by growing stocks, bound capital and issues of part ageing. A possible solution could be a virtual storage of spare parts which will be 3D printed through additive manufacturing technologies in case of sudden demand. As mechanical properties of additive manufactured parts are neither guaranteed by machine manufacturers nor by service providers, the utilization of this relatively young technology is impeded and research is required to address these issues. This paper presents an examination of mechanical properties of specimens manufactured from stainless steel through the selective laser melting (SLM) process. The specimens were produced in multiple batches. This paper interrogates the question if the test results follow a normal distribution pattern and if mechanical property predictions can be made. The results will be put opposite existing threshold values provided as the industrial standard. Furthermore, probability predictions will be made in order to examine the potential of the SLM process to maintain state-of-the-art mechanical property requirements.}, language = {en} } @article{WeiheAnsgarRoethetal.2013, author = {Weihe, Stefan and Ansgar, Ernst and R{\"o}th, Thilo and Proksch, Johannes}, title = {Leichtmetall-Stahl-Verbundguss im Nutzfahrzeugbau}, series = {Lightweight Design}, volume = {6}, journal = {Lightweight Design}, number = {2}, publisher = {Springer}, address = {Berlin}, issn = {2192-8738 (Online)}, pages = {38 -- 43}, year = {2013}, abstract = {In modernen Fahrzeugkarosserien der Großserie kommen zunehmend Materialmischbauweisen zur Anwendung. In Zusammenarbeit der Daimler AG, der Tower Automotive Holding GmbH, der Imperia GmbH sowie der Partnerunternehmen KSM Castings GmbH und Schaufler Tooling GmbH \& Co. KG wird das Leichtbaupotenzial von Stahlblech-AluminiumverbundgussHybriden am Beispiel des vorderen Dachquertr{\"a}gers des Mercedes-Benz Viano/Vito ausf{\"u}hrlich untersucht.}, language = {de} } @inproceedings{SchuhGottschalkHoehneetal.2008, author = {Schuh, G{\"u}nther and Gottschalk, Sebastian and H{\"o}hne, Tim and Attig, Philipp}, title = {Further Potentials of Smart Logistics}, series = {Manufacturing Systems and Technologies for the New Frontier}, booktitle = {Manufacturing Systems and Technologies for the New Frontier}, editor = {Mitsuishi, M.}, publisher = {Springer}, address = {London}, isbn = {978-1-84800-267-8}, doi = {10.1007/978-1-84800-267-8_18}, pages = {93 -- 96}, year = {2008}, language = {en} } @incollection{TippkoetterMoehringRothetal.2019, author = {Tippk{\"o}tter, Nils and M{\"o}hring, Sophie and Roth, Jasmine and Wulfhorst, Helene}, title = {Logistics of lignocellulosic feedstocks: preprocessing as a preferable option}, series = {Biorefineries}, booktitle = {Biorefineries}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-97117-9}, doi = {10.1007/10_2017_58}, pages = {43 -- 68}, year = {2019}, abstract = {In comparison to crude oil, biorefinery raw materials are challenging in concerns of transport and storage. The plant raw materials are more voluminous, so that shredding and compacting usually are necessary before transport. These mechanical processes can have a negative influence on the subsequent biotechnological processing and shelf life of the raw materials. Various approaches and their effects on renewable raw materials are shown. In addition, aspects of decentralized pretreatment steps are discussed. Another important aspect of pretreatment is the varying composition of the raw materials depending on the growth conditions. This problem can be solved with advanced on-site spectrometric analysis of the material.}, language = {en} } @incollection{DuweTippkoetterUlber2018, author = {Duwe, A. and Tippk{\"o}tter, Nils and Ulber, R.}, title = {Lignocellulose-Biorefinery: Ethanol-Focused}, series = {Biorefineries}, booktitle = {Biorefineries}, publisher = {Springer}, address = {Cham}, doi = {10.1007/10_2016_72}, pages = {177 -- 215}, year = {2018}, abstract = {The development prospects of the world markets for petroleum and other liquid fuels are diverse and partly contradictory. However, comprehensive changes for the energy supply of the future are essential. Notwithstanding the fact that there are still very large deposits of energy resources from a geological point of view, the finite nature of conventional oil reserves is indisputable. To reduce our dependence on oil, the EU, the USA, and other major economic zones rely on energy diversification. For this purpose, alternative materials and technologies are being sought, and is most obvious in the transport sector. The objective is to progressively replace fossil fuels with renewable and more sustainable fuels. In this respect, biofuels have a pre-eminent position in terms of their capability of blending with fossil fuels and being usable in existing cars without substantial modification. Ethanol can be considered as the primary renewable liquid fuel. In this chapter enzymes, micro-organisms, and processes for ethanol production based on renewable resources are described.}, language = {en} } @article{BeckerDelfmannDietrichetal.2016, author = {Becker, J{\"o}rg and Delfmann, Patrick and Dietrich, Hanns-Alexander and Steinhorst, Matthias and Eggert, Mathias}, title = {Business Process Compliance Checking — Applying and Evaluating a Generic Pattern Matching Approach for Conceptual Models in the Financial Sector}, series = {Information Systems Frontiers}, volume = {18}, journal = {Information Systems Frontiers}, number = {2}, publisher = {Springer}, address = {Berlin}, issn = {1572-9419}, doi = {10.1007/s10796-014-9529-y}, pages = {359 -- 405}, year = {2016}, abstract = {Given the strong increase in regulatory requirements for business processes the management of business process compliance becomes a more and more regarded field in IS research. Several methods have been developed to support compliance checking of conceptual models. However, their focus on distinct modeling languages and mostly linear (i.e., predecessor-successor related) compliance rules may hinder widespread adoption and application in practice. Furthermore, hardly any of them has been evaluated in a real-world setting. We address this issue by applying a generic pattern matching approach for conceptual models to business process compliance checking in the financial sector. It consists of a model query language, a search algorithm and a corresponding modelling tool prototype. It is (1) applicable for all graph-based conceptual modeling languages and (2) for different kinds of compliance rules. Furthermore, based on an applicability check, we (3) evaluate the approach in a financial industry project setting against its relevance for decision support of audit and compliance management tasks.}, language = {en} } @article{BeckerDelfmannEggertetal.2012, author = {Becker, J{\"o}rg and Delfmann, Patrick and Eggert, Mathias and Schwittay, Sebastian}, title = {Generalizability and Applicability of Model-Based Business Process Compliance-Checking Approaches — A State-of-the-Art Analysis and Research Roadmap}, series = {Business Research : BuR}, volume = {5}, journal = {Business Research : BuR}, number = {2}, publisher = {Springer}, address = {Heidelberg}, issn = {1866-8658}, doi = {10.1007/BF03342739}, pages = {221 -- 247}, year = {2012}, abstract = {With a steady increase of regulatory requirements for business processes, automation support of compliance management is a field garnering increasing attention in Information Systems research. Several approaches have been developed to support compliance checking of process models. One major challenge for such approaches is their ability to handle different modeling techniques and compliance rules in order to enable widespread adoption and application. Applying a structured literature search strategy, we reflect and discuss compliance-checking approaches in order to provide an insight into their generalizability and evaluation. The results imply that current approaches mainly focus on special modeling techniques and/or a restricted set of types of compliance rules. Most approaches abstain from real-world evaluation which raises the question of their practical applicability. Referring to the search results, we propose a roadmap for further research in model-based business process compliance checking.}, language = {en} } @incollection{YoshinobuKrauseMiyamotoetal.2018, author = {Yoshinobu, Tatsuo and Krause, Steffi and Miyamoto, Ko-ichiro and Werner, Frederik and Poghossian, Arshak and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {(Bio-)chemical Sensing and Imaging by LAPS and SPIM}, series = {Label-free biosensing: advanced materials, devices and applications}, booktitle = {Label-free biosensing: advanced materials, devices and applications}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-75219-8}, pages = {103 -- 132}, year = {2018}, abstract = {The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications.}, language = {en} } @article{SchneiderTran2015, author = {Schneider, Felix and Tran, Duc Hung}, title = {On the relation between the fair value option and bid-ask spreads: descriptive evidence on the recognition of credit risk changes under IFRS}, series = {Journal of Business Economics}, volume = {85}, journal = {Journal of Business Economics}, number = {9}, publisher = {Springer}, address = {Berlin}, issn = {1861-8928}, doi = {10.1007/s11573-015-0776-2}, pages = {1049 -- 1081}, year = {2015}, language = {en} } @article{Tran2011, author = {Tran, Duc Hung}, title = {Corporate Governance und Eigenkapitalkosten - Bestandsaufnahme des Schrifttums unter besonderer Ber{\"u}cksichtigung des Informationsaspektes und Forschungsperspektiven}, series = {Zeitschrift f{\"u}r Betriebswirtschaft}, volume = {81}, journal = {Zeitschrift f{\"u}r Betriebswirtschaft}, publisher = {Springer}, address = {Berlin}, issn = {1861-8928}, doi = {10.1007/s11573-011-0461-z}, pages = {551 -- 585}, year = {2011}, language = {de} } @article{FingerBraunBil2018, author = {Finger, Felix and Braun, Carsten and Bil, Cees}, title = {Impact of electric propulsion technology and mission requirements on the performance of VTOL UAVs}, series = {CEAS Aeronautical Journal}, volume = {10}, journal = {CEAS Aeronautical Journal}, number = {3}, publisher = {Springer}, issn = {1869-5582 print}, doi = {10.1007/s13272-018-0352-x}, pages = {843}, year = {2018}, abstract = {One of the engineering challenges in aviation is the design of transitioning vertical take-off and landing (VTOL) aircraft. Thrust-borne flight implies a higher mass fraction of the propulsion system, as well as much increased energy consumption in the take-off and landing phases. This mass increase is typically higher for aircraft with a separate lift propulsion system than for aircraft that use the cruise propulsion system to support a dedicated lift system. However, for a cost-benefit trade study, it is necessary to quantify the impact the VTOL requirement and propulsion configuration has on aircraft mass and size. For this reason, sizing studies are conducted. This paper explores the impact of considering a supplemental electric propulsion system for achieving hovering flight. Key variables in this study, apart from the lift system configuration, are the rotor disk loading and hover flight time, as well as the electrical systems technology level for both batteries and motors. Payload and endurance are typically used as the measures of merit for unmanned aircraft that carry electro-optical sensors, and therefore the analysis focuses on these particular parameters.}, language = {en} } @article{BergSchleserDelidovichetal.2018, author = {Berg, Alexander-Karl and Schleser, Markus and Delidovich, Artem and Houben, Alexander}, title = {Ultraschallunterst{\"u}tzter Schmelzklebstoffauftrag}, series = {adh{\"a}sion KLEBEN \& DICHTEN}, volume = {Volume 62}, journal = {adh{\"a}sion KLEBEN \& DICHTEN}, number = {Issue 12}, publisher = {Springer}, doi = {10.1007/s35145-018-0089-z}, pages = {32 -- 37}, year = {2018}, language = {de} } @article{ViethEisenbeiss2011, author = {Vieth, Matthias and Eisenbeiß, Maik}, title = {Die Geld-zur{\"u}ck-Garantie - Mehr als nur ein Qualit{\"a}tsindikator?}, series = {Zeitschrift f{\"u}r Betriebswirtschaft}, volume = {81}, journal = {Zeitschrift f{\"u}r Betriebswirtschaft}, number = {12}, publisher = {Springer}, address = {Berlin}, doi = {10.1007/s11573-011-0521-4}, pages = {1285 -- 1323}, year = {2011}, abstract = {Geld-zur{\"u}ck-Garantien erlangen in der Unternehmenspraxis eine immer gr{\"o}ßere Bedeutung, vor allem weil sie als probates Mittel zur Signalisierung hochwertiger Qualit{\"a}t angesehen werden - eine Annahme, die bislang wissenschaftlich ungepr{\"u}ft geblieben ist. Vor diesem Hintergrund wird im vorliegenden Beitrag eine umfassende empirische Untersuchung der kaufverhaltensrelevanten Wirkungen dieses Marketinginstrumentes vorgenommen. Die Ergebnisse verdeutlichen zum einen, dass eine Geld-zur{\"u}ck-Garantie nur unter bestimmten Bedingungen als Qualit{\"a}tssignal wirkt. Dies h{\"a}ngt neben der Art des Produktes (Erfahrungs- vs. Suchgut) insbesondere von der Auspr{\"a}gung des f{\"u}r die Qualit{\"a}tsbeurteilung besonders diagnostischen Merkmals Marke sowie von der Produktkenntnis der Konsumenten ab. Zum anderen zeigt sich aber auch, dass eine Geld-zur{\"u}ck-Garantie affektive Konsumentenreaktionen ausl{\"o}st, die die Kaufabsicht von Konsumenten zus{\"a}tzlich erh{\"o}hen k{\"o}nnen. Zusammenfassend stellen wir fest, dass eine Geld-zur{\"u}ck-Garantie - entgegen bisheriger Erwartungen aus der Praxis - nicht zwingend ein Qualit{\"a}tsindikator ist, stattdessen entfaltet sie aber bisher unbeachtete affektive Wirkungen, die insbesondere auf ihre absichernde Funktion von etwaigen Fehlentscheidungen beim Kauf zur{\"u}ckzuf{\"u}hren sind.}, language = {de} } @article{KramerValeroChansonetal.2019, author = {Kramer, Matthias and Valero, Daniel and Chanson, Hubert and Bung, Daniel B.}, title = {Towards reliable turbulence estimations with phase-detection probes: an adaptive window cross-correlation technique}, series = {Experiments in Fluids}, volume = {60}, journal = {Experiments in Fluids}, publisher = {Springer}, address = {Berlin}, issn = {1432-1114}, doi = {10.1007/s00348-018-2650-9}, year = {2019}, language = {en} } @article{WilsonDickieSchreiteretal.2018, author = {Wilson, C. E. and Dickie, A. P. and Schreiter, K. and Wehr, R. and Wilson, E. M. and Bial, J. and Scheer, Nico and Wilson, I. D. and Riley, R. J.}, title = {The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice}, series = {Archives of Toxicology}, volume = {92}, journal = {Archives of Toxicology}, number = {6}, publisher = {Springer}, issn = {1432-0738}, doi = {10.1007/s00204-018-2212-1}, pages = {1953 -- 1967}, year = {2018}, abstract = {The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.}, language = {en} } @article{RauppSchmittWalzetal.2018, author = {Raupp, Sebastian M. and Schmitt, Marcel and Walz, Anna-Lena and Diehm, Ralf and Hummel, Helga and Scharfer, Philip and Schabel, Wilhelm}, title = {Slot die stripe coating of low viscous fluids}, series = {Journal of Coatings Technology and Research}, volume = {15}, journal = {Journal of Coatings Technology and Research}, number = {5}, publisher = {Springer}, issn = {1935-3804}, doi = {10.1007/s11998-017-0039-y}, pages = {899 -- 911}, year = {2018}, abstract = {Slot die coating is applied to deposit thin and homogenous films in roll-to-roll and sheet-to-sheet applications. The critical step in operation is to choose suitable process parameters within the process window. In this work, we investigate an upper limit for stripe coatings. This maximum film thickness is characterized by stripe merging which needs to be avoided in a stable process. It is shown that the upper limit reduces the process window for stripe coatings to a major extent. As a result, stripe coatings at large coating gaps and low viscosities are only possible for relatively thick films. Explaining the upper limit, a theory of balancing the side pressure in the gap region in the cross-web direction has been developed.}, language = {en} } @incollection{DrummLemckeOberle2007, author = {Drumm, Christian and Lemcke, Jens and Oberle, Daniel}, title = {Business Process Management And Semantic Technologies}, series = {The Semantic Web}, booktitle = {The Semantic Web}, publisher = {Springer}, address = {Boston, MA}, isbn = {978-0-387-48531-7}, doi = {10.1007/978-0-387-48531-7_10}, pages = {207 -- 239}, year = {2007}, language = {en} } @incollection{MeskourisButenwegHinzenetal.2019, author = {Meskouris, Konstantin and Butenweg, Christoph and Hinzen, Klaus-G. and H{\"o}ffer, R{\"u}diger}, title = {Stochasticity of Wind Processes and Spectral Analysis of Structural Gust Response}, series = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, booktitle = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-57550-5 (Online)}, doi = {10.1007/978-3-662-57550-5_3}, pages = {153 -- 196}, year = {2019}, abstract = {Wind loads have great impact on many engineering structures. Wind storms often cause irreparable damage to the buildings which are exposed to it. Along with the earthquakes, wind represents one of the most common environmental load on structures and is relevant for limit state design. Modern wind codes indicate calculation procedures allowing engineers to deal with structural systems, which are susceptible to conduct wind-excited oscillations. In the codes approximate formulas for wind buffeting are specified which relate the dynamic problem to rather abstract parameter functions. The complete theory behind is not visible in order to simplify the applicability of the procedures. This chapter derives the underlying basic relations of the spectral method for wind buffeting and explains the main important applications of it in order to elucidate part of the theoretical background of computations after the new codes. The stochasticity of the wind processes is addressed, and the analysis of analytical as well as measurement based power spectra is outlined. Short MATLAB codes are added to the Appendix 3 which carry out the computation of a single sided auto-spectrum from a statistically stationary, discrete stochastic process. Two examples are presented.}, language = {en} } @incollection{DachwaldOhndorf2019, author = {Dachwald, Bernd and Ohndorf, Andreas}, title = {Global optimization of continuous-thrust trajectories using evolutionary neurocontrol}, series = {Modeling and Optimization in Space Engineering}, booktitle = {Modeling and Optimization in Space Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-10501-3}, doi = {10.1007/978-3-030-10501-3_2}, pages = {33 -- 57}, year = {2019}, abstract = {Searching optimal continuous-thrust trajectories is usually a difficult and time-consuming task. The solution quality of traditional optimal-control methods depends strongly on an adequate initial guess because the solution is typically close to the initial guess, which may be far from the (unknown) global optimum. Evolutionary neurocontrol attacks continuous-thrust optimization problems from the perspective of artificial intelligence and machine learning, combining artificial neural networks and evolutionary algorithms. This chapter describes the method and shows some example results for single- and multi-phase continuous-thrust trajectory optimization problems to assess its performance. Evolutionary neurocontrol can explore the trajectory search space more exhaustively than a human expert can do with traditional optimal-control methods. Especially for difficult problems, it usually finds solutions that are closer to the global optimum. Another fundamental advantage is that continuous-thrust trajectories can be optimized without an initial guess and without expert supervision.}, language = {en} } @article{VoegeleRuebbelkeGovorukhaetal.2019, author = {V{\"o}gele, Stefan and R{\"u}bbelke, Dirk and Govorukha, Kristina and Grajewski, Matthias}, title = {Socio-technical scenarios for energy-intensive industries: the future of steel production in Germany}, series = {Climatic Change}, journal = {Climatic Change}, publisher = {Springer}, address = {Berlin}, issn = {0165-0009}, doi = {10.1007/s10584-019-02366-0}, pages = {1 -- 16}, year = {2019}, language = {en} } @incollection{Eggert2019, author = {Eggert, Mathias}, title = {Big Data Research - How to Structure the Changes of the Past Decade?}, series = {The Art of Structuring}, booktitle = {The Art of Structuring}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-06234-7}, doi = {10.1007/978-3-030-06234-7_26}, pages = {271 -- 281}, year = {2019}, abstract = {In the past decade, many IS researchers focused on researching the phenomenon of Big Data. At the same time, the relevance of data protection gets more attention than ever before. In particular, since the enactment of the European General Data Protection Regulation in May 2018 Information Systems research should provide answers for protecting personal data. The article at hand presents a structuring framework for Big Data research outcome and the consideration of data protection. IS Researchers might use the framework in order to structure Big Data literature and to identify research gaps that should be addressed in the future.}, language = {en} } @incollection{FranzenSteckenPfaffetal.2019, author = {Franzen, Julian and Stecken, Jannis and Pfaff, Raphael and Kuhlenk{\"o}tter, Bernd}, title = {Using the Digital Shadow for a Prescriptive Optimization of Maintenance and Operation : The Locomotive in the Context of the Cyber-Physical System}, series = {Advances in Production, Logistics and Traffic}, booktitle = {Advances in Production, Logistics and Traffic}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-13535-5}, doi = {10.1007/978-3-030-13535-5_19}, pages = {265 -- 276}, year = {2019}, abstract = {In competition with other modes of transport, rail freight transport is looking for solutions to become more attractive. Short-term success can be achieved through the data-driven optimization of operations and maintenance as well as the application of novel strategies such as prescriptive maintenance. After introducing the concept of prescriptive maintenance, this paper aims to prove that vehicle-focused applications of this approach indeed have the potential to increase attractiveness. However, even greater advantages can be activated if data from the horizontal network of the vehicle is available. Drawing on the state of the art in research and technology in the field of cyber-physical systems (CPS) as well as digital twins and shadows, our work serves to design a system of systems for the horizontal interconnection of a rail vehicle and to conceptualize a draft for a digital twin of a locomotive.}, language = {en} } @article{SchildtBraunMarzocca2019, author = {Schildt, Ph. and Braun, Carsten and Marzocca, P.}, title = {Metric evaluating potentials of condition-monitoring approaches for hybrid electric aircraft propulsion systems}, series = {CEAS Aeronautical Journal}, journal = {CEAS Aeronautical Journal}, publisher = {Springer}, address = {Berlin}, issn = {1869-5590}, doi = {10.1007/s13272-019-00411-3}, pages = {1 -- 14}, year = {2019}, language = {en} } @incollection{RaoPathroseHueningetal.2019, author = {Rao, Deepak and Pathrose, Plato and H{\"u}ning, Felix and Sid, Jithin}, title = {An Approach for Validating Safety of Perception Software in Autonomous Driving Systems}, series = {Model-Based Safety and Assessment: 6th International Symposium, IMBSA 2019, Thessaloniki, Greece, October 16-18, 2019, Proceedings}, booktitle = {Model-Based Safety and Assessment: 6th International Symposium, IMBSA 2019, Thessaloniki, Greece, October 16-18, 2019, Proceedings}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-32872-6}, doi = {10.1007/978-3-030-32872-6_20}, pages = {303 -- 316}, year = {2019}, abstract = {The increasing complexity of Advanced Driver Assistance Systems (ADAS) presents a challenging task to validate safe and reliable performance of these systems under varied conditions. The test and validation of ADAS/AD with real test drives, although important, involves huge costs and time. Simulation tools provide an alternative with the added advantage of reproducibility but often use ideal sensors, which do not reflect real sensor output accurately. This paper presents a new validation methodology using fault injection, as recommended by the ISO 26262 standard, to test software and system robustness. In our work, we investigated and developed a tool capable of inserting faults at different software and system levels to verify its robustness. The scope of this paper is to cover the fault injection test for the Visteon's DriveCore™ system, a centralized domain controller for Autonomous driving which is sensor agnostic and SoC agnostic. With this new approach, the validation of safety monitoring functionality and its behavior can be tested using real-world data instead of synthetic data from simulation tools resulting in having better confidence in system performance before proceeding with in-vehicle testing.}, language = {en} } @article{Stulpe2019, author = {Stulpe, Werner}, title = {Aspects of the Quantum-Classical Connection Based on Statistical Maps}, series = {Foundations of Physics}, volume = {49}, journal = {Foundations of Physics}, number = {6}, publisher = {Springer}, address = {Berlin}, doi = {10.1007/s10701-019-00269-9}, pages = {677 -- 692}, year = {2019}, language = {en} } @article{KromeHoeftSander2019, author = {Krome, Cornelia and H{\"o}ft, Jan and Sander, Volker}, title = {Clustering time series applied to energy markets}, series = {Energy Informatics}, volume = {2}, journal = {Energy Informatics}, number = {Article numer 17}, publisher = {Springer}, address = {Berlin}, issn = {2520-8942}, doi = {10.1186/s42162-019-0076-0}, pages = {1 -- 20}, year = {2019}, language = {en} } @article{GronsfeldJoachimMalecha2019, author = {Gronsfeld, Richard and Joachim, Klubert and Malecha, Hartmut}, title = {3-D-Visualisierung von vorhandenen Staubauwerken zur holistischen Planung und {\"U}berwachung}, series = {Wasserwirtschaft}, volume = {109}, journal = {Wasserwirtschaft}, number = {5}, publisher = {Springer}, address = {Berlin}, issn = {2192-8762}, doi = {10.1007/s35147-019-0075-x}, pages = {82 -- 85}, year = {2019}, language = {de} } @article{OrzadaFiedlerBitzetal.2020, author = {Orzada, Stephan and Fiedler, Thomas M. and Bitz, Andreas and Ladd, Mark E. and Quick, Harald H.}, title = {Local SAR compression with overestimation control to reduce maximum relative SAR overestimation and improve multi-channel RF array performance}, series = {Magnetic Resonance Materials in Physics, Biology and Medicine}, journal = {Magnetic Resonance Materials in Physics, Biology and Medicine}, number = {34 (2021)}, publisher = {Springer}, address = {Heidelberg}, isbn = {1352-8661}, doi = {10.1007/s10334-020-00890-0}, pages = {153 -- 164}, year = {2020}, abstract = {Objective In local SAR compression algorithms, the overestimation is generally not linearly dependent on actual local SAR. This can lead to large relative overestimation at low actual SAR values, unnecessarily constraining transmit array performance. Method Two strategies are proposed to reduce maximum relative overestimation for a given number of VOPs. The first strategy uses an overestimation matrix that roughly approximates actual local SAR; the second strategy uses a small set of pre-calculated VOPs as the overestimation term for the compression. Result Comparison with a previous method shows that for a given maximum relative overestimation the number of VOPs can be reduced by around 20\% at the cost of a higher absolute overestimation at high actual local SAR values. Conclusion The proposed strategies outperform a previously published strategy and can improve the SAR compression where maximum relative overestimation constrains the performance of parallel transmission.}, language = {en} } @article{MayerHentschkeHageretal.2017, author = {Mayer, Jan and Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils and Karimi-Varnaneh, Hossein Ali}, title = {A Nano-Mechanical Instability as Primary Contribution to Rolling Resistance}, series = {Scientific Reports}, volume = {7}, journal = {Scientific Reports}, number = {Article number 11275}, publisher = {Springer}, address = {Berlin}, issn = {2045-2322}, year = {2017}, language = {en} } @article{HarishWriggersJungketal.2016, author = {Harish, Ajay B. and Wriggers, Peter and Jungk, Juliane and Hojdis, Nils and Recker, Carla}, title = {Mesoscale Constitutive Modeling of Non-Crystallizing Filled Elastomers}, series = {Computational Mechanics}, volume = {57}, journal = {Computational Mechanics}, publisher = {Springer}, address = {Berlin}, issn = {1432-0924}, doi = {10.1007/s00466-015-1251-1}, pages = {653 -- 677}, year = {2016}, abstract = {Elastomers are exceptional materials owing to their ability to undergo large deformations before failure. However, due to their very low stiffness, they are not always suitable for industrial applications. Addition of filler particles provides reinforcing effects and thus enhances the material properties that render them more versatile for applications like tyres etc. However, deformation behavior of filled polymers is accompanied by several nonlinear effects like Mullins and Payne effect. To this day, the physical and chemical changes resulting in such nonlinear effect remain an active area of research. In this work, we develop a heterogeneous (or multiphase) constitutive model at the mesoscale explicitly considering filler particle aggregates, elastomeric matrix and their mechanical interaction through an approximate interface layer. The developed constitutive model is used to demonstrate cluster breakage, also, as one of the possible sources for Mullins effect observed in non-crystallizing filled elastomers.}, language = {en} } @inproceedings{LorenzAltherrPelz2020, author = {Lorenz, Imke-Sophie and Altherr, Lena and Pelz, Peter F.}, title = {Assessing and Optimizing the Resilience of Water Distribution Systems Using Graph-Theoretical Metrics}, series = {Operations Research Proceedings 2019}, booktitle = {Operations Research Proceedings 2019}, editor = {Neufeld, Janis S. and Buscher, Udo and Lasch, Rainer and M{\"o}st, Dominik and Sch{\"o}nberger, J{\"o}rn}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-48439-2}, doi = {10.1007/978-3-030-48439-2_63}, pages = {521 -- 527}, year = {2020}, abstract = {Water distribution systems are an essential supply infrastructure for cities. Given that climatic and demographic influences will pose further challenges for these infrastructures in the future, the resilience of water supply systems, i.e. their ability to withstand and recover from disruptions, has recently become a subject of research. To assess the resilience of a WDS, different graph-theoretical approaches exist. Next to general metrics characterizing the network topology, also hydraulic and technical restrictions have to be taken into account. In this work, the resilience of an exemplary water distribution network of a major German city is assessed, and a Mixed-Integer Program is presented which allows to assess the impact of capacity adaptations on its resilience.}, language = {en} } @inproceedings{LeiseSimonAltherr2020, author = {Leise, Philipp and Simon, Nicolai and Altherr, Lena}, title = {Comparison of Piecewise Linearization Techniques to Model Electric Motor Efficiency Maps: A Computational Study}, series = {Operations Research Proceedings 2019}, booktitle = {Operations Research Proceedings 2019}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-48439-2}, doi = {10.1007/978-3-030-48439-2_55}, pages = {457 -- 463}, year = {2020}, abstract = {To maximize the travel distances of battery electric vehicles such as cars or buses for a given amount of stored energy, their powertrains are optimized energetically. One key part within optimization models for electric powertrains is the efficiency map of the electric motor. The underlying function is usually highly nonlinear and nonconvex and leads to major challenges within a global optimization process. To enable faster solution times, one possibility is the usage of piecewise linearization techniques to approximate the nonlinear efficiency map with linear constraints. Therefore, we evaluate the influence of different piecewise linearization modeling techniques on the overall solution process and compare the solution time and accuracy for methods with and without explicitly used binary variables.}, language = {en} } @incollection{AltherrEdererLorenzetal.2016, author = {Altherr, Lena and Ederer, Thorsten and Lorenz, Ulf and Pelz, Peter F. and P{\"o}ttgen, Philipp}, title = {Designing a feedback control system via mixed-integer programming}, series = {Operations Research Proceedings 2014: Selected Papers of the Annual International Conference of the German Operations Research}, booktitle = {Operations Research Proceedings 2014: Selected Papers of the Annual International Conference of the German Operations Research}, editor = {L{\"u}bbecke, Marco E. and Koster, Arie and Letmathe, Peter and Madlener, Reihard and Preis, Britta and Walther, Grit}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-28695-2}, doi = {10.1007/978-3-319-28697-6_18}, pages = {121 -- 127}, year = {2016}, abstract = {Pure analytical or experimental methods can only find a control strategy for technical systems with a fixed setup. In former contributions we presented an approach that simultaneously finds the optimal topology and the optimal open-loop control of a system via Mixed Integer Linear Programming (MILP). In order to extend this approach by a closed-loop control we present a Mixed Integer Program for a time discretized tank level control. This model is the basis for an extension by combinatorial decisions and thus for the variation of the network topology. Furthermore, one is able to appraise feasible solutions using the global optimality gap.}, language = {en} } @incollection{Kotliar2021, author = {Kotliar, Konstantin}, title = {Ocular rigidity: clinical approach}, series = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye}, booktitle = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye}, editor = {Pallikaris, I. and Tsilimbaris, M. K. and Dastiridou, A. I.}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-64422-2}, doi = {10.1007/978-3-030-64422-2_2}, pages = {15 -- 43}, year = {2021}, abstract = {The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications.}, language = {en} } @article{KuertenKotliarFuestetal.2021, author = {Kuerten, David and Kotliar, Konstantin and Fuest, Matthias and Walter, Peter and Hollstein, Muriel and Plange, Niklas}, title = {Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study}, series = {International Ophthalmology}, volume = {41}, journal = {International Ophthalmology}, number = {41}, editor = {Neri, Piergiorgio}, publisher = {Springer}, address = {Berlin}, isbn = {1573-2630}, doi = {10.1007/s10792-021-01876-0}, pages = {3109 -- 3119}, year = {2021}, abstract = {Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect.}, language = {en} } @incollection{PfetschAbeleAltherretal.2021, author = {Pfetsch, Marc E. and Abele, Eberhard and Altherr, Lena and B{\"o}lling, Christian and Br{\"o}tz, Nicolas and Dietrich, Ingo and Gally, Tristan and Geßner, Felix and Groche, Peter and Hoppe, Florian and Kirchner, Eckhard and Kloberdanz, Hermann and Knoll, Maximilian and Kolvenbach, Philip and Kuttich-Meinlschmidt, Anja and Leise, Philipp and Lorenz, Ulf and Matei, Alexander and Molitor, Dirk A. and Niessen, Pia and Pelz, Peter F. and Rexer, Manuel and Schmitt, Andreas and Schmitt, Johann M. and Schulte, Fiona and Ulbrich, Stefan and Weigold, Matthias}, title = {Strategies for mastering uncertainty}, series = {Mastering uncertainty in mechanical engineering}, booktitle = {Mastering uncertainty in mechanical engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-78353-2}, doi = {10.1007/978-3-030-78354-9_6}, pages = {365 -- 456}, year = {2021}, abstract = {This chapter describes three general strategies to master uncertainty in technical systems: robustness, flexibility and resilience. It builds on the previous chapters about methods to analyse and identify uncertainty and may rely on the availability of technologies for particular systems, such as active components. Robustness aims for the design of technical systems that are insensitive to anticipated uncertainties. Flexibility increases the ability of a system to work under different situations. Resilience extends this characteristic by requiring a given minimal functional performance, even after disturbances or failure of system components, and it may incorporate recovery. The three strategies are described and discussed in turn. Moreover, they are demonstrated on specific technical systems.}, language = {en} } @inproceedings{MuellerSchmittLeiseetal.2021, author = {M{\"u}ller, Tim M. and Schmitt, Andreas and Leise, Philipp and Meck, Tobias and Altherr, Lena and Pelz, Peter F. and Pfetsch, Marc E.}, title = {Validation of an optimized resilient water supply system}, series = {Uncertainty in Mechanical Engineering}, booktitle = {Uncertainty in Mechanical Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-77255-0}, doi = {10.1007/978-3-030-77256-7_7}, pages = {70 -- 80}, year = {2021}, abstract = {Component failures within water supply systems can lead to significant performance losses. One way to address these losses is the explicit anticipation of failures within the design process. We consider a water supply system for high-rise buildings, where pump failures are the most likely failure scenarios. We explicitly consider these failures within an early design stage which leads to a more resilient system, i.e., a system which is able to operate under a predefined number of arbitrary pump failures. We use a mathematical optimization approach to compute such a resilient design. This is based on a multi-stage model for topology optimization, which can be described by a system of nonlinear inequalities and integrality constraints. Such a model has to be both computationally tractable and to represent the real-world system accurately. We therefore validate the algorithmic solutions using experiments on a scaled test rig for high-rise buildings. The test rig allows for an arbitrary connection of pumps to reproduce scaled versions of booster station designs for high-rise buildings. We experimentally verify the applicability of the presented optimization model and that the proposed resilience properties are also fulfilled in real systems.}, language = {en} } @incollection{LeiseAltherrSimonetal.2019, author = {Leise, Philipp and Altherr, Lena and Simon, Nicolai and Pelz, Peter F.}, title = {Finding global-optimal gearbox designs for battery electric vehicles}, series = {Optimization of complex systems - theory, models, algorithms and applications : WCGO 2019}, booktitle = {Optimization of complex systems - theory, models, algorithms and applications : WCGO 2019}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-21802-7}, doi = {10.1007/978-3-030-21803-4_91}, pages = {916 -- 925}, year = {2019}, abstract = {In order to maximize the possible travel distance of battery electric vehicles with one battery charge, it is mandatory to adjust all components of the powertrain carefully to each other. While current vehicle designs mostly simplify the powertrain rigorously and use an electric motor in combination with a gearbox with only one fixed transmission ratio, the use of multi-gear systems has great potential. First, a multi-speed system is able to improve the overall energy efficiency. Secondly, it is able to reduce the maximum momentum and therefore to reduce the maximum current provided by the traction battery, which results in a longer battery lifetime. In this paper, we present a systematic way to generate multi-gear gearbox designs that—combined with a certain electric motor—lead to the most efficient fulfillment of predefined load scenarios and are at the same time robust to uncertainties in the load. Therefore, we model the electric motor and the gearbox within a Mixed-Integer Nonlinear Program, and optimize the efficiency of the mechanical parts of the powertrain. By combining this mathematical optimization program with an unsupervised machine learning algorithm, we are able to derive global-optimal gearbox designs for practically relevant momentum and speed requirements.}, language = {en} } @incollection{StengerAltherrAbel2019, author = {Stenger, David and Altherr, Lena and Abel, Dirk}, title = {Machine learning and metaheuristics for black-box optimization of product families: a case-study investigating solution quality vs. computational overhead}, series = {Operations Research Proceedings 2018}, booktitle = {Operations Research Proceedings 2018}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-18499-5 (Print)}, doi = {10.1007/978-3-030-18500-8_47}, pages = {379 -- 385}, year = {2019}, abstract = {In product development, numerous design decisions have to be made. Multi-domain virtual prototyping provides a variety of tools to assess technical feasibility of design options, however often requires substantial computational effort for just a single evaluation. A special challenge is therefore the optimal design of product families, which consist of a group of products derived from a common platform. Finding an optimal platform configuration (stating what is shared and what is individually designed for each product) and an optimal design of all products simultaneously leads to a mixed-integer nonlinear black-box optimization model. We present an optimization approach based on metamodels and a metaheuristic. To increase computational efficiency and solution quality, we compare different types of Gaussian process regression metamodels adapted from the domain of machine learning, and combine them with a genetic algorithm. We illustrate our approach on the example of a product family of electrical drives, and investigate the trade-off between solution quality and computational overhead.}, language = {en} } @incollection{MuellerAltherrAholaetal.2018, author = {M{\"u}ller, Tim M. and Altherr, Lena and Ahola, Marja and Schabel, Samuel and Pelz, Peter F.}, title = {Optimizing pressure screen systems in paper recycling: optimal system layout, component selection and operation}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-18499-5}, doi = {10.1007/978-3-030-18500-8_44}, pages = {355 -- 361}, year = {2018}, abstract = {Around 60\% of the paper worldwide is made from recovered paper. Especially adhesive contaminants, so called stickies, reduce paper quality. To remove stickies but at the same time keep as many valuable fibers as possible, multi-stage screening systems with several interconnected pressure screens are used. When planning such systems, suitable screens have to be selected and their interconnection as well as operational parameters have to be defined considering multiple conflicting objectives. In this contribution, we present a Mixed-Integer Nonlinear Program to optimize system layout, component selection and operation to find a suitable trade-off between output quality and yield.}, language = {en} } @inproceedings{MeckMuellerAltherretal.2020, author = {Meck, Marvin M. and M{\"u}ller, Tim M. and Altherr, Lena and Pelz, Peter F.}, title = {Improving an industrial cooling system using MINLP, considering capital and operating costs}, series = {Operations Research Proceedings 2019}, booktitle = {Operations Research Proceedings 2019}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-48438-5 (Print)}, doi = {10.1007/978-3-030-48439-2_61}, pages = {505 -- 512}, year = {2020}, abstract = {The chemical industry is one of the most important industrial sectors in Germany in terms of manufacturing revenue. While thermodynamic boundary conditions often restrict the scope for reducing the energy consumption of core processes, secondary processes such as cooling offer scope for energy optimisation. In this contribution, we therefore model and optimise an existing cooling system. The technical boundary conditions of the model are provided by the operators, the German chemical company BASF SE. In order to systematically evaluate different degrees of freedom in topology and operation, we formulate and solve a Mixed-Integer Nonlinear Program (MINLP), and compare our optimisation results with the existing system.}, language = {en} } @article{MuellerLeiseLorenzetal.2020, author = {M{\"u}ller, Tim M. and Leise, Philipp and Lorenz, Imke-Sophie and Altherr, Lena and Pelz, Peter F.}, title = {Optimization and validation of pumping system design and operation for water supply in high-rise buildings}, series = {Optimization and Engineering}, volume = {2021}, journal = {Optimization and Engineering}, number = {22}, publisher = {Springer}, issn = {1573-2924}, doi = {10.1007/s11081-020-09553-4}, pages = {643 -- 686}, year = {2020}, abstract = {The application of mathematical optimization methods for water supply system design and operation provides the capacity to increase the energy efficiency and to lower the investment costs considerably. We present a system approach for the optimal design and operation of pumping systems in real-world high-rise buildings that is based on the usage of mixed-integer nonlinear and mixed-integer linear modeling approaches. In addition, we consider different booster station topologies, i.e. parallel and series-parallel central booster stations as well as decentral booster stations. To confirm the validity of the underlying optimization models with real-world system behavior, we additionally present validation results based on experiments conducted on a modularly constructed pumping test rig. Within the models we consider layout and control decisions for different load scenarios, leading to a Deterministic Equivalent of a two-stage stochastic optimization program. We use a piecewise linearization as well as a piecewise relaxation of the pumps' characteristics to derive mixed-integer linear models. Besides the solution with off-the-shelf solvers, we present a problem specific exact solving algorithm to improve the computation time. Focusing on the efficient exploration of the solution space, we divide the problem into smaller subproblems, which partly can be cut off in the solution process. Furthermore, we discuss the performance and applicability of the solution approaches for real buildings and analyze the technical aspects of the solutions from an engineer's point of view, keeping in mind the economically important trade-off between investment and operation costs.}, language = {en} } @incollection{StengerAltherrMuelleretal.2018, author = {Stenger, David and Altherr, Lena and M{\"u}ller, Tankred and Pelz, Peter F.}, title = {Product family design optimization using model-based engineering techniques}, series = {Operations Research Proceedings 2017}, booktitle = {Operations Research Proceedings 2017}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-89919-0}, doi = {10.1007/978-3-319-89920-6_66}, pages = {495 -- 502}, year = {2018}, abstract = {Highly competitive markets paired with tremendous production volumes demand particularly cost efficient products. The usage of common parts and modules across product families can potentially reduce production costs. Yet, increasing commonality typically results in overdesign of individual products. Multi domain virtual prototyping enables designers to evaluate costs and technical feasibility of different single product designs at reasonable computational effort in early design phases. However, savings by platform commonality are hard to quantify and require detailed knowledge of e.g. the production process and the supply chain. Therefore, we present and evaluate a multi-objective metamodel-based optimization algorithm which enables designers to explore the trade-off between high commonality and cost optimal design of single products.}, language = {en} } @incollection{AltherrDoerigEdereretal.2017, author = {Altherr, Lena and D{\"o}rig, Bastian and Ederer, Thorsten and Pelz, Peter Franz and Pfetsch, Marc and Wolf, Jan}, title = {A mixed-integer nonlinear program for the design of gearboxes}, series = {Operations Research Proceedings 2016}, booktitle = {Operations Research Proceedings 2016}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-55701-4}, doi = {10.1007/978-3-319-55702-1_31}, pages = {227 -- 233}, year = {2017}, abstract = {Gearboxes are mechanical transmission systems that provide speed and torque conversions from a rotating power source. Being a central element of the drive train, they are relevant for the efficiency and durability of motor vehicles. In this work, we present a new approach for gearbox design: Modeling the design problem as a mixed-integer nonlinear program (MINLP) allows us to create gearbox designs from scratch for arbitrary requirements and—given enough time—to compute provably globally optimal designs for a given objective. We show how different degrees of freedom influence the runtime and present an exemplary solution.}, language = {en} } @incollection{LeiseAltherrPelz2018, author = {Leise, Philipp and Altherr, Lena and Pelz, Peter F.}, title = {Energy-Efficient design of a water supply system for skyscrapers by mixed-integer nonlinear programming}, series = {Operations Research Proceedings 2017}, booktitle = {Operations Research Proceedings 2017}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-89919-0}, doi = {10.1007/978-3-319-89920-6_63}, year = {2018}, abstract = {The energy-efficiency of technical systems can be improved by a systematic design approach. Technical Operations Research (TOR) employs methods known from Operations Research to find a global optimal layout and operation strategy of technical systems. We show the practical usage of this approach by the systematic design of a decentralized water supply system for skyscrapers. All possible network options and operation strategies are modeled by a Mixed-Integer Nonlinear Program. We present the optimal system found by our approach and highlight the energy savings compared to a conventional system design.}, language = {en} } @inproceedings{RauschFriesenAltherretal.2018, author = {Rausch, Lea and Friesen, John and Altherr, Lena and Pelz, Peter F.}, title = {Using mixed-integer programming for the optimal design of water supply networks for slums}, series = {Operations Research Proceedings 2017}, booktitle = {Operations Research Proceedings 2017}, editor = {Kliewer, Natalia and Ehmke, Jan Fabian and Bornd{\"o}rfer, Ralf}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-89919-0 (Print)}, doi = {10.1007/978-3-319-89920-6_68}, pages = {509 -- 516}, year = {2018}, abstract = {The UN sets the goal to ensure access to water and sanitation for all people by 2030. To address this goal, we present a multidisciplinary approach for designing water supply networks for slums in large cities by applying mathematical optimization. The problem is modeled as a mixed-integer linear problem (MILP) aiming to find a network describing the optimal supply infrastructure. To illustrate the approach, we apply it on a small slum cluster in Dhaka, Bangladesh.}, language = {en} } @article{LenzKahmannBehbahanietal.2022, author = {Lenz, Maximilian and Kahmann, Stephanie Lucina and Behbahani, Mehdi and Pennig, Lenhard and Hackl, Michael and Leschinger, Tim and M{\"u}ller, Lars Peter and Wegmann, Kilian}, title = {Influence of rotator cuff preload on fracture configuration in proximal humerus fractures: a proof of concept for fracture simulation}, series = {Archives of Orthopaedic and Trauma Surgery}, journal = {Archives of Orthopaedic and Trauma Surgery}, publisher = {Springer}, address = {Berlin, Heidelberg}, issn = {1434-3916}, doi = {10.1007/s00402-022-04471-9}, year = {2022}, abstract = {Introduction In regard of surgical training, the reproducible simulation of life-like proximal humerus fractures in human cadaveric specimens is desirable. The aim of the present study was to develop a technique that allows simulation of realistic proximal humerus fractures and to analyse the influence of rotator cuff preload on the generated lesions in regards of fracture configuration. Materials and methods Ten cadaveric specimens (6 left, 4 right) were fractured using a custom-made drop-test bench, in two groups. Five specimens were fractured without rotator cuff preload, while the other five were fractured with the tendons of the rotator cuff preloaded with 2 kg each. The humeral shaft and the shortened scapula were potted. The humerus was positioned at 90° of abduction and 10° of internal rotation to simulate a fall on the elevated arm. In two specimens of each group, the emergence of the fractures was documented with high-speed video imaging. Pre-fracture radiographs were taken to evaluate the deltoid-tuberosity index as a measure of bone density. Post-fracture X-rays and CT scans were performed to define the exact fracture configurations. Neer's classification was used to analyse the fractures. Results In all ten cadaveric specimens life-like proximal humerus fractures were achieved. Two III-part and three IV-part fractures resulted in each group. The preloading of the rotator cuff muscles had no further influence on the fracture configuration. High-speed videos of the fracture simulation revealed identical fracture mechanisms for both groups. We observed a two-step fracture mechanism, with initial impaction of the head segment against the glenoid followed by fracturing of the head and the tuberosities and then with further impaction of the shaft against the acromion, which lead to separation of the tuberosities. Conclusion A high energetic axial impulse can reliably induce realistic proximal humerus fractures in cadaveric specimens. The preload of the rotator cuff muscles had no influence on initial fracture configuration. Therefore, fracture simulation in the proximal humerus is less elaborate. Using the presented technique, pre-fractured specimens are available for real-life surgical education.}, language = {en} } @article{SchneiderSchwabedalBialonski2022, author = {Schneider, Jules and Schwabedal, Justus T. C. and Bialonski, Stephan}, title = {Schlafspindeln - Funktion, Detektion und Nutzung als Biomarker f{\"u}r die psychiatrische Diagnostik}, series = {Der Nervenarzt}, journal = {Der Nervenarzt}, publisher = {Springer}, address = {Berlin, Heidelberg}, issn = {1433-0407}, doi = {10.1007/s00115-022-01340-z}, pages = {1 -- 8}, year = {2022}, abstract = {Hintergrund: Die Schlafspindel ist ein Graphoelement des Elektroenzephalogramms (EEG), das im Leicht- und Tiefschlaf beobachtet werden kann. Ver{\"a}nderungen der Spindelaktivit{\"a}t wurden f{\"u}r verschiedene psychiatrische Erkrankungen beschrieben. Schlafspindeln zeigen aufgrund ihrer relativ konstanten Eigenschaften Potenzial als Biomarker in der psychiatrischen Diagnostik. Methode: Dieser Beitrag liefert einen {\"U}berblick {\"u}ber den Stand der Wissenschaft zu Eigenschaften und Funktionen der Schlafspindeln sowie {\"u}ber beschriebene Ver{\"a}nderungen der Spindelaktivit{\"a}t bei psychiatrischen Erkrankungen. Verschiedene methodische Ans{\"a}tze und Ausblicke zur Spindeldetektion werden hinsichtlich deren Anwendungspotenzial in der psychiatrischen Diagnostik erl{\"a}utert. Ergebnisse und Schlussfolgerung: W{\"a}hrend Ver{\"a}nderungen der Spindelaktivit{\"a}t bei psychiatrischen Erkrankungen beschrieben wurden, ist deren exaktes Potenzial f{\"u}r die psychiatrische Diagnostik noch nicht ausreichend erforscht. Diesbez{\"u}glicher Erkenntnisgewinn wird in der Forschung gegenw{\"a}rtig durch ressourcenintensive und fehleranf{\"a}llige Methoden zur manuellen oder automatisierten Spindeldetektion ausgebremst. Neuere Detektionsans{\"a}tze, die auf Deep-Learning-Verfahren basieren, k{\"o}nnten die Schwierigkeiten bisheriger Detektionsmethoden {\"u}berwinden und damit neue M{\"o}glichkeiten f{\"u}r die praktisch}, language = {de} } @incollection{LeichtScholtenSteuerDankert2020, author = {Leicht-Scholten, Carmen and Steuer-Dankert, Linda}, title = {Educating engineers for socially responsible solutions through design thinking}, series = {Design thinking in higher education: interdisciplinary encounters}, booktitle = {Design thinking in higher education: interdisciplinary encounters}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-15-5780-4}, doi = {10.1007/978-981-15-5780-4}, pages = {229 -- 246}, year = {2020}, abstract = {There is a broad international discussion about rethinking engineering education in order to educate engineers to cope with future challenges, and particularly the sustainable development goals. In this context, there is a consensus about the need to shift from a mostly technical paradigm to a more holistic problem-based approach, which can address the social embeddedness of technology in society. Among the strategies suggested to address this social embeddedness, design thinking has been proposed as an essential complement to engineering precisely for this purpose. This chapter describes the requirements for integrating the design thinking approach in engineering education. We exemplify the requirements and challenges by presenting our approach based on our course experiences at RWTH Aachen University. The chapter first describes the development of our approach of integrating design thinking in engineering curricula, how we combine it with the Sustainable Development Goals (SDG) as well as the role of sustainability and social responsibility in engineering. Secondly, we present the course "Expanding Engineering Limits: Culture, Diversity, and Gender" at RWTH Aachen University. We describe the necessity to theoretically embed the method in social and cultural context, giving students the opportunity to reflect on cultural, national, or individual "engineering limits," and to be able to overcome them using design thinking as a next step for collaborative project work. The paper will suggest that the successful implementation of design thinking as a method in engineering education needs to be framed and contextualized within Science and Technology Studies (STS).}, language = {en} } @incollection{BraunerVervierBrillowskietal.2022, author = {Brauner, Philipp and Vervier, Luisa and Brillowski, Florian and Dammers, Hannah and Steuer-Dankert, Linda and Schneider, Sebastian and Baier, Ralph and Ziefle, Martina and Gries, Thomas and Leicht-Scholten, Carmen and Mertens, Alexander and Nagel, Saskia K.}, title = {Organization Routines in Next Generation Manufacturing}, series = {Forecasting Next Generation Manufacturing}, booktitle = {Forecasting Next Generation Manufacturing}, publisher = {Springer}, address = {Cham}, isbn = {978-3-031-07734-0}, doi = {10.1007/978-3-031-07734-0_5}, pages = {75 -- 94}, year = {2022}, abstract = {Next Generation Manufacturing promises significant improvements in performance, productivity, and value creation. In addition to the desired and projected improvements regarding the planning, production, and usage cycles of products, this digital transformation will have a huge impact on work, workers, and workplace design. Given the high uncertainty in the likelihood of occurrence and the technical, economic, and societal impacts of these changes, we conducted a technology foresight study, in the form of a real-time Delphi analysis, to derive reliable future scenarios featuring the next generation of manufacturing systems. This chapter presents the organization dimension and describes each projection in detail, offering current case study examples and discussing related research, as well as implications for policy makers and firms. Specifically, we highlight seven areas in which the digital transformation of production will change how we work, how we organize the work within a company, how we evaluate these changes, and how employment and labor rights will be affected across company boundaries. The experts are unsure whether the use of collaborative robots in factories will replace traditional robots by 2030. They believe that the use of hybrid intelligence will supplement human decision-making processes in production environments. Furthermore, they predict that artificial intelligence will lead to changes in management processes, leadership, and the elimination of hierarchies. However, to ensure that social and normative aspects are incorporated into the AI algorithms, restricting measurement of individual performance will be necessary. Additionally, AI-based decision support can significantly contribute toward new, socially accepted modes of leadership. Finally, the experts believe that there will be a reduction in the workforce by the year 2030.}, language = {en} } @incollection{HinkeVervierBrauneretal.2022, author = {Hinke, Christian and Vervier, Luisa and Brauner, Philipp and Schneider, Sebastian and Steuer-Dankert, Linda and Ziefle, Martina and Leicht-Scholten, Carmen}, title = {Capability configuration in next generation manufacturing}, series = {Forecasting next generation manufacturing : digital shadows, human-machine collaboration, and data-driven business models}, booktitle = {Forecasting next generation manufacturing : digital shadows, human-machine collaboration, and data-driven business models}, publisher = {Springer}, address = {Cham}, isbn = {978-3-031-07733-3}, doi = {10.1007/978-3-031-07734-0_6}, pages = {95 -- 106}, year = {2022}, abstract = {Industrial production systems are facing radical change in multiple dimensions. This change is caused by technological developments and the digital transformation of production, as well as the call for political and social change to facilitate a transformation toward sustainability. These changes affect both the capabilities of production systems and companies and the design of higher education and educational programs. Given the high uncertainty in the likelihood of occurrence and the technical, economic, and societal impacts of these concepts, we conducted a technology foresight study, in the form of a real-time Delphi analysis, to derive reliable future scenarios featuring the next generation of manufacturing systems. This chapter presents the capabilities dimension and describes each projection in detail, offering current case study examples and discussing related research, as well as implications for policy makers and firms. Specifically, we discuss the benefits of capturing expert knowledge and making it accessible to newcomers, especially in highly specialized industries. The experts argue that in order to cope with the challenges and circumstances of today's world, students must already during their education at university learn how to work with AI and other technologies. This means that study programs must change and that universities must adapt their structural aspects to meet the needs of the students.}, language = {en} } @incollection{FateriGebhardt2020, author = {Fateri, Miranda and Gebhardt, Andreas}, title = {Introduction to Additive Manufacturing}, series = {3D Printing of Optical Components}, booktitle = {3D Printing of Optical Components}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-58960-8}, doi = {10.1007/978-3-030-58960-8_1}, pages = {1 -- 22}, year = {2020}, abstract = {Additive manufacturing (AM) works by creating objects layer by layer in a manner similar to a 2D printer with the "printed" layers stacked on top of each other. The layer-wise manufacturing nature of AM enables fabrication of freeform geometries which cannot be fabricated using conventional manufacturing methods as a one part. Depending on how each layer is created and bonded to the adjacent layers, different AM methods have been developed. In this chapter, the basic terms, common materials, and different methods of AM are described, and their potential applications are discussed.}, language = {en} } @incollection{ButenwegHoltschoppen2019, author = {Butenweg, Christoph and Holtschoppen, Britta}, title = {Seismic design of structures and components in industrial units}, series = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, booktitle = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-57550-5}, doi = {10.1007/978-3-662-57550-5_5}, pages = {359 -- 481}, year = {2019}, abstract = {Industrial units consist of the primary load-carrying structure and various process engineering components, the latter being by far the most important in financial terms. In addition, supply structures such as free-standing tanks and silos are usually required for each plant to ensure the supply of material and product storage. Thus, for the earthquake-proof design of industrial plants, design and construction rules are required for the primary structures, the secondary structures and the supply structures. Within the framework of these rules, possible interactions of primary and secondary structures must also be taken into account. Importance factors are used in seismic design in order to take into account the usually higher risk potential of an industrial unit compared to conventional building structures. Industrial facilities must be able to withstand seismic actions because of possibly wide-ranging damage consequences in addition to losses due to production standstill and the destruction of valuable equipment. The chapter presents an integrated concept for the seismic design of industrial units based on current seismic standards and the latest research results. Special attention is devoted to the seismic design of steel thin-walled silos and tank structures.}, language = {en} } @incollection{GiresiniButenweg2019, author = {Giresini, Linda and Butenweg, Christoph}, title = {Earthquake resistant design of structures according to Eurocode 8}, series = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, booktitle = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-57550-5 (Online)}, doi = {10.1007/978-3-662-57550-5_4}, pages = {197 -- 358}, year = {2019}, abstract = {The chapter initially provides a summary of the contents of Eurocode 8, its aim being to offer both to the students and to practising engineers an easy introduction into the calculation and dimensioning procedures of this earthquake code. Specifically, the general rules for earthquake-resistant structures, the definition of design response spectra taking behaviour and importance factors into account, the application of linear and non-linear calculation methods and the structural safety verifications at the serviceability and ultimate limit state are presented. The application of linear and non-linear calculation methods and corresponding seismic design rules is demonstrated on practical examples for reinforced concrete, steel and masonry buildings. Furthermore, the seismic assessment of existing buildings is discussed and illustrated on the example of a typical historical masonry building in Italy. The examples are worked out in detail and each step of the design process, from the preliminary analysis to the final design, is explained in detail.}, language = {en} } @incollection{GebhardtHoetter2019, author = {Gebhardt, Andreas and Hoetter, Jan-Steffen}, title = {Rapid Tooling}, series = {CIRP Encyclopedia of Production Engineering}, booktitle = {CIRP Encyclopedia of Production Engineering}, publisher = {Springer}, address = {Berlin, Heidelberg}, isbn = {978-3-662-53120-4}, doi = {10.1007/978-3-662-53120-4}, pages = {39 -- 52}, year = {2019}, language = {en} } @incollection{BozakovSander2013, author = {Bozakov, Zdravko and Sander, Volker}, title = {OpenFlow: A Perspective for Building Versatile Networks}, series = {Network-Embedded Management and Applications}, booktitle = {Network-Embedded Management and Applications}, publisher = {Springer}, address = {New York, NY}, isbn = {978-1-4419-6769-5}, doi = {10.1007/978-1-4419-6769-5_11}, pages = {217 -- 245}, year = {2013}, language = {en} } @article{RossiHoltschoppenButenweg2019, author = {Rossi, Leonardo and Holtschoppen, Britta and Butenweg, Christoph}, title = {Official data on the economic consequences of the 2012 Emilia-Romagna earthquake: a first analysis of database SFINGE}, series = {Bulletin of Earthquake Engineering}, volume = {17}, journal = {Bulletin of Earthquake Engineering}, number = {9}, publisher = {Springer}, address = {Berlin}, doi = {10.1007\%2Fs10518-019-00655-8}, pages = {4855 -- 4884}, year = {2019}, language = {en} } @article{ButenwegMarinkovicSalatic2019, author = {Butenweg, Christoph and Marinkovic, Marko and Salatic, Ratko}, title = {Experimental results of reinforced concrete frames with masonry infills under combined quasi-static in-plane and out-of-plane seismic loading}, series = {Bulletin of Earthquake Engineering}, volume = {17}, journal = {Bulletin of Earthquake Engineering}, publisher = {Springer}, address = {Berlin}, issn = {1573-1456}, doi = {10.1007/s10518-019-00602-7}, pages = {3397 -- 3422}, year = {2019}, language = {en} } @incollection{IbanezSanchezWolf2020, author = {Ibanez-Sanchez, Gema and Wolf, Martin}, title = {Interactive Process Mining-Induced Change Management Methodology for Healthcare}, series = {Interactive Process Mining in Healthcare}, booktitle = {Interactive Process Mining in Healthcare}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-53993-1 (Online)}, doi = {10.1007/978-3-030-53993-1_16}, pages = {267 -- 293}, year = {2020}, abstract = {The adoption of the Digital Health Transformation is a tremendous paradigm change in health organizations, which is not a trivial process in reality. For that reason, in this chapter, it is proposed a methodology with the objective to generate a changing culture in healthcare organisations. Such a change culture is essential for the successful implementation of any supporting methods like Interactive Process Mining. It needs to incorporate (mostly) new ways of team-based and evidence-based approaches for solving structural problems in a digital healthcare environment.}, language = {en} } @article{HugenrothBorchardtRitteretal.2021, author = {Hugenroth, Kristin and Borchardt, Ralf and Ritter, Philine and Groß‑Hardt, Sascha and Meyns, Bart and Verbelen, Tom and Steinseifer, Ulrich and Kaufmann, Tim A. S. and Engelmann, Ulrich M.}, title = {Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input}, series = {Scientific Reports}, volume = {11}, journal = {Scientific Reports}, number = {Art. No. 16800}, publisher = {Springer}, address = {Berlin}, issn = {2045-2322}, doi = {10.1038/s41598-021-96397-2}, pages = {1 -- 12}, year = {2021}, abstract = {Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5\% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6\%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.}, language = {en} } @inproceedings{KaschSchmidtEichleretal.2020, author = {Kasch, Susanne and Schmidt, Thomas and Eichler, Fabian and Thurn, Laura and Jahn, Simon and Bremen, Sebastian}, title = {Solution approaches and process concepts for powder bed-based melting of glass}, series = {Industrializing Additive Manufacturing. Proceedings of AMPA2020}, booktitle = {Industrializing Additive Manufacturing. Proceedings of AMPA2020}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-54333-4 (Print)}, doi = {10.1007/978-3-030-54334-1_7}, pages = {82 -- 95}, year = {2020}, abstract = {In the study, the process chain of additive manufacturing by means of powder bed fusion will be presented based on the material glass. In order to reliably process components additively, new concepts with different solutions were developed and investigated. Compared to established metallic materials, the properties of glass materials differ significantly. Therefore, the process control was adapted to the material glass in the investigations. With extensive parameter studies based on various glass powders such as borosilicate glass and quartz glass, scientifically proven results on powder bed fusion of glass are presented. Based on the determination of the particle properties with different methods, extensive investigations are made regarding the melting behavior of glass by means of laser beams. Furthermore, the experimental setup was steadily expanded. In addition to the integration of coaxial temperature measurement and regulation, preheating of the building platform is of major importance. This offers the possibility to perform 3D printing at the transformation temperatures of the glass materials. To improve the component's properties, the influence of a subsequent heat treatment was also investigated. The experience gained was incorporated into a new experimental system, which allows a much better exploration of the 3D printing of glass. Currently, studies are being conducted to improve surface texture, building accuracy, and geometrical capabilities using three-dimensional specimen. The contribution shows the development of research in the field of 3D printing of glass, gives an insight into the machine and process engineering as well as an outlook on the possibilities and applications.}, language = {en} } @article{AltherrEdererLorenzetal.2014, author = {Altherr, Lena and Ederer, Thorsten and Lorenz, Ulf and Pelz, Peter F. and P{\"o}ttgen, Philipp}, title = {Experimental validation of an enhanced system synthesis approach}, series = {Operations Research Proceedings 2014}, journal = {Operations Research Proceedings 2014}, editor = {L{\"u}bbecke, Marco and Koster, Arie and Letmathe, Peter and Madlener, Reihard and Peis, Britta and Walther, Grit}, publisher = {Springer}, address = {Basel}, isbn = {978-3-319-28695-2}, doi = {10.1007/978-3-319-28697-6_1}, pages = {6}, year = {2014}, abstract = {Planning the layout and operation of a technical system is a common task for an engineer. Typically, the workflow is divided into consecutive stages: First, the engineer designs the layout of the system, with the help of his experience or of heuristic methods. Secondly, he finds a control strategy which is often optimized by simulation. This usually results in a good operating of an unquestioned sys- tem topology. In contrast, we apply Operations Research (OR) methods to find a cost-optimal solution for both stages simultaneously via mixed integer program- ming (MILP). Technical Operations Research (TOR) allows one to find a provable global optimal solution within the model formulation. However, the modeling error due to the abstraction of physical reality remains unknown. We address this ubiq- uitous problem of OR methods by comparing our computational results with mea- surements in a test rig. For a practical test case we compute a topology and control strategy via MILP and verify that the objectives are met up to a deviation of 8.7\%.}, language = {en} } @incollection{AltherrLeise2021, author = {Altherr, Lena and Leise, Philipp}, title = {Resilience as a concept for mastering uncertainty}, series = {Mastering Uncertainty in Mechanical Engineering}, booktitle = {Mastering Uncertainty in Mechanical Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-78353-2}, doi = {10.1007/978-3-030-78354-9}, pages = {412 -- 417}, year = {2021}, language = {en} } @incollection{AltherrLeisePfetschetal.2021, author = {Altherr, Lena and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas}, title = {Optimal design of resilient technical systems on the example of water supply systems}, series = {Mastering Uncertainty in Mechanical Engineering}, booktitle = {Mastering Uncertainty in Mechanical Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-78356-3}, pages = {429 -- 433}, year = {2021}, language = {en} } @incollection{LeiseAltherr2021, author = {Leise, Philipp and Altherr, Lena}, title = {Experimental evaluation of resilience metrics in a fluid system}, series = {Mastering Uncertainty in Mechanical Engineering}, booktitle = {Mastering Uncertainty in Mechanical Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-78356-3}, pages = {442 -- 447}, year = {2021}, language = {en} } @incollection{BensbergBuscherCzarnecki2019, author = {Bensberg, Frank and Buscher, Gandalf and Czarnecki, Christian}, title = {Digital transformation and IT topics in the consulting industry: a labor market perspective}, series = {Advances in consulting research : recent findings and practical cases}, booktitle = {Advances in consulting research : recent findings and practical cases}, editor = {Nissen, Volker}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-95998-6}, doi = {10.1007/978-3-319-95999-3_16}, pages = {341 -- 357}, year = {2019}, abstract = {Information technologies, such as big data analytics, cloud computing, cyber physical systems, robotic process automation, and the internet of things, provide a sustainable impetus for the structural development of business sectors as well as the digitalization of markets, enterprises, and processes. Within the consulting industry, the proliferation of these technologies opened up the new segment of digital transformation, which focuses on setting up, controlling, and implementing projects for enterprises from a broad range of sectors. These recent developments raise the question, which requirements evolve for IT consultants as important success factors of those digital transformation projects. Therefore, this empirical contribution provides indications regarding the qualifications and competences necessary for IT consultants in the era of digital transformation from a labor market perspective. On the one hand, this knowledge base is interesting for the academic education of consultants, since it supports a market-oriented design of adequate training measures. On the other hand, insights into the competence requirements for consultants are considered relevant for skill and talent management processes in consulting practice. Assuming that consulting companies pursue a strategic human resource management approach, labor market information may also be useful to discover strategic behavioral patterns.}, language = {en} } @incollection{SchmitzDietzeCzarnecki2019, author = {Schmitz, Manfred and Dietze, Christian and Czarnecki, Christian}, title = {Enabling digital transformation through robotic process automation at Deutsche Telekom}, series = {Enabling digital transformation through robotic process automation at Deutsche Telekom}, booktitle = {Enabling digital transformation through robotic process automation at Deutsche Telekom}, editor = {Urbach, Nils and R{\"o}glinger, Maximilian}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-95272-7}, doi = {10.1007/978-3-319-95273-4_2}, pages = {15 -- 33}, year = {2019}, abstract = {Due to the high number of customer contacts, fault clearances, installations, and product provisioning per year, the automation level of operational processes has a significant impact on financial results, quality, and customer experience. Therefore, the telecommunications operator Deutsche Telekom (DT) has defined a digital strategy with the objectives of zero complexity and zero complaint, one touch, agility in service, and disruptive thinking. In this context, Robotic Process Automation (RPA) was identified as an enabling technology to formulate and realize DT's digital strategy through automation of rule-based, routine, and predictable tasks in combination with structured and stable data.}, language = {en} } @incollection{CzarneckiAuth2018, author = {Czarnecki, Christian and Auth, Gunnar}, title = {Prozessdigitalisierung durch Robotic 7 Process Automation}, series = {Digitalisierung in Unternehmen: von den theoretischen Ans{\"a}tzen zur praktischen Umsetzung}, booktitle = {Digitalisierung in Unternehmen: von den theoretischen Ans{\"a}tzen zur praktischen Umsetzung}, editor = {Barton, Thomas and M{\"u}ller, Christian and Seel, Christian}, publisher = {Springer}, address = {Wiesbaden}, isbn = {9783658227739}, doi = {10.1007/978-3-658-22773-9_7}, pages = {113 -- 131}, year = {2018}, abstract = {Im Rahmen der digitalen Transformation werden innovative Technologiekonzepte, wie z. B. das Internet der Dinge und Cloud Computing als Treiber f{\"u}r weitreichende Ver{\"a}nderungen von Organisationen und Gesch{\"a}ftsmodellen angesehen. In diesem Kontext ist Robotic Process Automation (RPA) ein neuartiger Ansatz zur Prozessautomatisierung, bei dem manuelle T{\"a}tigkeiten durch sogenannte Softwareroboter erlernt und automatisiert ausgef{\"u}hrt werden. Dabei emulieren Softwareroboter die Eingaben auf der bestehenden Pr{\"a}sentationsschicht, so dass keine {\"A}nderungen an vorhandenen Anwendungssystemen notwendig sind. Die innovative Idee ist die Transformation der bestehenden Prozessausf{\"u}hrung von manuell zu digital, was RPA von traditionellen Ans{\"a}tzen des Business Process Managements (BPM) unterscheidet, bei denen z. B. prozessgetriebene Anpassungen auf Ebene der Gesch{\"a}ftslogik notwendig sind. Am Markt werden bereits unterschiedliche RPA-L{\"o}sungen als Softwareprodukte angeboten. Gerade bei operativen Prozessen mit sich wiederholenden Verarbeitungsschritten in unterschiedlichen Anwendungssystemen sind gute Ergebnisse durch RPA dokumentiert, wie z. B. die Automatisierung von 35 \% der Backoffice-Prozesse bei Telefonica. Durch den vergleichsweise niedrigen Implementierungsaufwand verbunden mit einem hohen Automatisierungspotenzial ist in der Praxis (z. B. Banken, Telekommunikation, Energieversorgung) ein hohes Interesse an RPA vorhanden. Der Beitrag diskutiert RPA als innovativen Ansatz zur Prozessdigitalisierung und gibt konkrete Handlungsempfehlungen f{\"u}r die Praxis. Dazu wird zwischen modellgetriebenen und selbstlernenden Ans{\"a}tzen unterschieden. Anhand von generellen Architekturen von RPA-Systemen werden Anwendungsszenarien sowie deren Automatisierungspotenziale, aber auch Einschr{\"a}nkungen, diskutiert. Es folgt ein strukturierter Markt{\"u}berblick ausgew{\"a}hlter RPA-Produkte. Anhand von drei konkreten Anwendungsbeispielen wird die Nutzung von RPA in der Praxis verdeutlicht.}, language = {de} } @incollection{SchneiderWisselinkCzarnecki2018, author = {Schneider, Dominik and Wisselink, Frank and Czarnecki, Christian}, title = {Nutzen und Rahmenbedingungen 5 informationsgetriebener Gesch{\"a}ftsmodelle des Internets der Dinge}, series = {Digitalisierung in Unternehmen: von den theoretischen Ans{\"a}tzen zur praktischen Umsetzung}, booktitle = {Digitalisierung in Unternehmen: von den theoretischen Ans{\"a}tzen zur praktischen Umsetzung}, editor = {Barton, Thomas and M{\"u}ller, Christian and Seel, Christian}, publisher = {Springer}, address = {Wiesbaden}, isbn = {9783658227739}, doi = {10.1007/978-3-658-22773-9_5}, pages = {67 -- 85}, year = {2018}, abstract = {Im Kontext der zunehmenden Digitalisierung wird das Internet der Dinge (englisch: Internet of Things, IoT) als ein technologischer Treiber angesehen, durch den komplett neue Gesch{\"a}ftsmodelle im Zusammenspiel unterschiedlicher Akteure entstehen k{\"o}nnen. Identifizierte Schl{\"u}sselakteure sind unter anderem traditionelle Industrieunternehmen, Kommunen und Telekommunikationsunternehmen. Letztere sorgen mit der Bereitstellung von Konnektivit{\"a}t daf{\"u}r, dass kleine Ger{\"a}te mit winzigen Batterien nahezu {\"u}berall und direkt an das Internet angebunden werden k{\"o}nnen. Es sind schon viele IoT-Anwendungsf{\"a}lle auf dem Markt, die eine Vereinfachung f{\"u}r Endkunden darstellen, wie beispielsweise Philips Hue Tap. Neben Gesch{\"a}ftsmodellen basierend auf Konnektivit{\"a}t besteht ein großes Potenzial f{\"u}r informationsgetriebene Gesch{\"a}ftsmodelle, die bestehende Gesch{\"a}ftsmodelle unterst{\"u}tzen sowie weiterentwickeln k{\"o}nnen. Ein Beispiel daf{\"u}r ist der IoT-Anwendungsfall Park and Joy der Deutschen Telekom AG, bei dem Parkpl{\"a}tze mithilfe von Sensoren vernetzt und Autofahrer in Echtzeit {\"u}ber verf{\"u}gbare Parkpl{\"a}tze informiert werden. Informationsgetriebene Gesch{\"a}ftsmodelle k{\"o}nnen auf Daten aufsetzen, die in IoT-Anwendungsf{\"a}llen erzeugt werden. Zum Beispiel kann ein Telekommunikationsunternehmen Mehrwert sch{\"o}pfen, indem es aus Daten entscheidungsrelevantere Informationen - sogenannte Insights - ableitet, die zur Steigerung der Entscheidungsagilit{\"a}t genutzt werden. Außerdem k{\"o}nnen Insights monetarisiert werden. Die Monetarisierung von Insights kann nur nachhaltig stattfinden, wenn sorgf{\"a}ltig gehandelt wird und Rahmenbedingungen ber{\"u}cksichtigt werden. In diesem Kapitel wird das Konzept informationsgetriebener Gesch{\"a}ftsmodelle erl{\"a}utert und anhand des konkreten Anwendungsfalls Park and Joy verdeutlicht. Dar{\"u}ber hinaus werden Nutzen, Risiken und Rahmenbedingungen diskutiert.}, language = {de} } @article{MonakhovaDiehl2021, author = {Monakhova, Yulia and Diehl, Bernd W. K.}, title = {Simplification of NMR Workflows by Standardization Using 2H Integral of Deuterated Solvent as Applied to Aloe vera Preparations}, series = {Applied Magnetic Resonance}, volume = {52}, journal = {Applied Magnetic Resonance}, number = {11}, publisher = {Springer}, address = {Cham}, issn = {1613-7507}, doi = {10.1007/s00723-021-01393-4}, pages = {1591 -- 1600}, year = {2021}, abstract = {In this study, a recently proposed NMR standardization approach by 2H integral of deuterated solvent for quantitative multicomponent analysis of complex mixtures is presented. As a proof of principle, the existing NMR routine for the analysis of Aloe vera products was modified. Instead of using absolute integrals of targeted compounds and internal standard (nicotinamide) from 1H-NMR spectra, quantification was performed based on the ratio of a particular 1H-NMR compound integral and 2H-NMR signal of deuterated solvent D2O. Validation characteristics (linearity, repeatability, accuracy) were evaluated and the results showed that the method has the same precision as internal standardization in case of multicomponent screening. Moreover, a dehydration process by freeze drying is not necessary for the new routine. Now, our NMR profiling of A. vera products needs only limited sample preparation and data processing. The new standardization methodology provides an appealing alternative for multicomponent NMR screening. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and is recommended in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).}, language = {en} } @article{CzarneckiBensbergAuth2019, author = {Czarnecki, Christian and Bensberg, Frank and Auth, Gunnar}, title = {Die Rolle von Softwarerobotern f{\"u}r die zuk{\"u}nftige Arbeitswelt}, series = {HMD Praxis der Wirtschaftsinformatik}, volume = {56}, journal = {HMD Praxis der Wirtschaftsinformatik}, number = {4}, publisher = {Springer}, address = {Cham}, issn = {2198-2775}, doi = {10.1365/s40702-019-00548-z}, pages = {795 -- 808}, year = {2019}, abstract = {Im Rahmen der Digitalisierung ist die zunehmende Automatisierung von bisher manuellen Prozessschritten ein Aspekt, der massive Auswirkungen auf die zuk{\"u}nftige Arbeitswelt haben wird. In diesem Kontext werden an den Einsatz von Softwarerobotern zur Prozessautomatisierung hohe Erwartungen gekn{\"u}pft. Bei den Implementierungsans{\"a}tzen wird die Diskussion aktuell insbesondere durch Robotic Process Automation (RPA) und Chatbots gepr{\"a}gt. Beide Ans{\"a}tze verfolgen das gemeinsame Ziel einer 1:1-Automatisierung von menschlichen Handlungen und dadurch ein direktes Ersetzen von Mitarbeitern durch Maschinen. Bei RPA werden Prozesse durch Softwareroboter erlernt und automatisiert ausgef{\"u}hrt. Dabei emulieren RPA-Roboter die Eingaben auf der bestehenden Pr{\"a}sentationsschicht, so dass keine {\"A}nderungen an vorhandenen Anwendungssystemen notwendig sind. Am Markt werden bereits unterschiedliche RPA-L{\"o}sungen als Softwareprodukte angeboten. Durch Chatbots werden Ein- und Ausgaben von Anwendungssystemen {\"u}ber nat{\"u}rliche Sprache realisiert. Dadurch ist die Automatisierung von unternehmensexterner Kommunikation (z. B. mit Kunden) aber auch von unternehmensinternen Assistenzt{\"a}tigkeiten m{\"o}glich. Der Beitrag diskutiert die Auswirkungen von Softwarerobotern auf die Arbeitswelt anhand von Anwendungsbeispielen und erl{\"a}utert die unternehmensindividuelle Entscheidung {\"u}ber den Einsatz von Softwarerobotern anhand von Effektivit{\"a}ts- und Effizienzzielen.}, language = {de} }