@article{KotliarHanssenEberhardtetal.2013, author = {Kotliar, Konstantin and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Schmaderer, Christoph and Halle, Martin and Heemann, Uwe and Baumann, M.}, title = {Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects}, series = {Microcirculation}, journal = {Microcirculation}, publisher = {Wiley}, address = {Malden}, issn = {1549-8719}, year = {2013}, language = {en} } @article{AridaTurekRolkaetal.2009, author = {Arida, Hassan and Turek, Monika and Rolka, David and Sch{\"o}ning, Michael Josef}, title = {A Novel Thin-Film Copper Array Based on an Organic/Inorganic Sensor Hybrid: Microfabrication, Potentiometric Characterization, and Flow-Injection Analysis Application}, series = {Electroanalysis. 21 (2009), H. 10}, journal = {Electroanalysis. 21 (2009), H. 10}, publisher = {Wiley}, address = {Weinheim}, isbn = {1040-0397}, pages = {1145 -- 1151}, year = {2009}, language = {en} } @article{MorenoiCodinachsBirkenstockGarmaetal.2009, author = {Moreno i Codinachs, L. and Birkenstock, C. and Garma, T. and Zierold, R. and Bachmann, J. and Nielsch, K. and Sch{\"o}ning, Michael Josef and Fontcuberta i Morral, A.}, title = {A micron-sized nanoporous multifunction sensing device}, series = {physica status solidi (a) . 206 (2009), H. 3}, journal = {physica status solidi (a) . 206 (2009), H. 3}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {435 -- 441}, year = {2009}, language = {en} } @article{NaetherHenkelSchneideretal.2009, author = {N{\"a}ther, Niko and Henkel, Hartmut and Schneider, Andreas and Sch{\"o}ning, Michael Josef}, title = {Investigation of different catalytically active and passive materials for realising a hydrogen peroxide gas sensor}, series = {physica status solidi (a) . 206 (2009), H. 3}, journal = {physica status solidi (a) . 206 (2009), H. 3}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {449 -- 454}, year = {2009}, language = {en} } @article{SiqueiraAbouzarBaeckeretal.2009, author = {Siqueira, Jos{\´e} R. Jr. and Abouzar, Maryam H. and B{\"a}cker, Matthias and Zucolotto, Valtencir and Poghossian, Arshak and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors}, series = {physica status solidi (a) . 206 (2009), H. 3}, journal = {physica status solidi (a) . 206 (2009), H. 3}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {462 -- 467}, year = {2009}, language = {en} } @article{MilnickelGrap2011, author = {Milnickel, Birte and Grap, Rolf Dietmar}, title = {Chemielogistik im Kontext allgemeiner logistischer Anforderungen}, series = {Chemielogistik : Markt, Gesch{\"a}ftsmodelle, Prozesse}, journal = {Chemielogistik : Markt, Gesch{\"a}ftsmodelle, Prozesse}, editor = {Suntrop, Carsten}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {978-3-527-32531-3}, pages = {3 -- 22}, year = {2011}, language = {de} } @article{BohrnStuetzFleischeretal.2011, author = {Bohrn, Ulrich and St{\"u}tz, Evamaria and Fleischer, Maximilian and Sch{\"o}ning, Michael Josef and Wagner, Patrick}, title = {Eukaryotic cell lines as a sensitive layer for direct monitoring of carbon monoxide}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1345 -- 1350}, year = {2011}, language = {en} } @article{BaeckerPouyeshmanSchnitzleretal.2011, author = {B{\"a}cker, Matthias and Pouyeshman, S. and Schnitzler, Thomas and Poghossian, Arshak and Wagner, Patrick and Biselli, Manfred and Sch{\"o}ning, Michael Josef}, title = {A silicon-based multi-sensor chip for monitoring of fermentation processes}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1364 -- 1369}, year = {2011}, language = {en} } @article{WernerKrumbeSchumacheretal.2011, author = {Werner, Frederik and Krumbe, Christoph and Schumacher, Katharina and Groebel, Simone and Spelthahn, Heiko and Stellberg, Michael and Wagner, Torsten and Yoshinobu, Tatsuo and Selmer, Thorsten and Keusgen, Michael and Baumann, Marcus and Sch{\"o}ning, Michael Josef}, title = {Determination of the extracellular acidification of Escherichia coli by a light-addressable potentiometric sensor}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1340 -- 1344}, year = {2011}, language = {en} } @article{KirchnerOberlaenderFriedrichetal.2011, author = {Kirchner, Patrick and Oberl{\"a}nder, Jan and Friedrich, Peter and Berger, J{\"o}rg and Suso, Henri-Pierre and Kupyna, Andriy and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Optimisation and fabrication of a calorimetric gas sensor built up on a polyimide substrate for H2O2 monitoring}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1235 -- 1240}, year = {2011}, language = {en} } @article{ReisertGeisslerFloerkeetal.2011, author = {Reisert, Steffen and Geissler, Hanno and Fl{\"o}rke, Rudolf and N{\"a}ther, Niko and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Towards a multi-sensor system for the evaluation of aseptic processes employing hydrogen peroxide vapour (H2O2)}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1351 -- 1356}, year = {2011}, language = {en} } @article{OehlschlaegerQuettingAlvarezetal.2009, author = {{\"O}hlschl{\"a}ger, Peter and Quetting, Michael and Alvarez, Gerardo and D{\"u}rst, Matthias and Gissmann, Lutz and Kaufmann, Andreas M.}, title = {Enhancement of immunogenicity of a therapeutic cervical cancer DNA-based vaccine by co-application of sequence-optimized genetic adjuvants}, series = {International Journal of Cancer}, volume = {125}, journal = {International Journal of Cancer}, number = {1}, publisher = {Wiley}, address = {Weinheim}, isbn = {1097-0215}, pages = {189 -- 198}, year = {2009}, language = {en} } @article{OosterhuisOehlschlaegerBergetal.2011, author = {Oosterhuis, Koen and {\"O}hlschl{\"a}ger, Peter and Berg, Joost H. van den and Toebes, Mireille and Gomez, Raquel and Schumacher, Ton N. and Haanen, John B.}, title = {Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7}, series = {International Journal of Cancer}, volume = {129}, journal = {International Journal of Cancer}, number = {2}, publisher = {Wiley}, address = {Weinheim}, isbn = {1097-0215}, pages = {397 -- 406}, year = {2011}, language = {en} } @article{OehlschlaegerSpiesAlvarezetal.2011, author = {{\"O}hlschl{\"a}ger, Peter and Spies, Elmar and Alvarez, Gerardo and Quetting, Michael and Groettrup, Marcus}, title = {The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA}, series = {International Journal of Cancer. 128 (2011), H. 2}, journal = {International Journal of Cancer. 128 (2011), H. 2}, publisher = {Wiley}, address = {Weinheim}, isbn = {1097-0215}, pages = {473 -- 481}, year = {2011}, language = {en} } @article{LeursMezoOehlschlaegeretal.2012, author = {Leurs, Ulrike and Mezo, Gabor and {\"O}hlschl{\"a}ger, Peter and Orban, Erika and Marquard, Andrea and Manea, Marilena}, title = {Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety}, series = {Peptide Science}, volume = {98}, journal = {Peptide Science}, number = {1}, publisher = {Wiley}, address = {New York, NY}, issn = {1097-0282}, doi = {10.1002/bip.21640}, pages = {1 -- 10}, year = {2012}, abstract = {Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.}, language = {en} } @article{StaatTrenzLohmannetal.2012, author = {Staat, Manfred and Trenz, Eva and Lohmann, Philipp and Frotscher, Ralf and Klinge, Uwe and Tabaza, Ruth and Kirschner-Hermanns, Ruth}, title = {New measurements to compare soft tissue anchoring systems in pelvic floor surgery}, series = {Journal of Biomedical Materials Research Part B: Applied Biomaterials}, volume = {100B}, journal = {Journal of Biomedical Materials Research Part B: Applied Biomaterials}, number = {4}, publisher = {Wiley}, address = {Hoboken, NJ}, issn = {1552-4981}, doi = {10.1002/jbm.b.32654}, pages = {924 -- 933}, year = {2012}, abstract = {Suburethral slings as well as different meshes are widely used treating stress urinary incontinence and prolaps in women. With the development of MiniSlings and special meshes using less alloplastic material anchorage systems become more important to keep devices in place and to put some tension especially on the MiniSlings. To date, there are many different systems of MiniSlings of different companies on the market which differ in the structure of the used meshes and anchors. A new objective measurement method to compare different properties of MiniSling systems (mesh and anchor) is presented in this article. Ballistic gelatine acts as soft tissue surrogate. Significant differences in parameters like pull-out strength of anchors or shrinkage of meshes under loading conditions have been determined. The form and size of the anchors as well as the structural stability of the meshes are decisive for a proper integration. The tested anchorings sytems showed markedly different mechanical function at their respective load bearing capacity. As the stable fixation of the device in tissue is a prerequisite for a permanet reinforcement, the proposed test system permits further optimisation of anchor and mesh devices to improve the success of the surgical treatment}, language = {en} } @article{LanzlSeidovaMaieretal.2011, author = {Lanzl, Ines M. and Seidova, Seid-Fatima and Maier, Mathias and Schmidt-Trucks{\"a}ss, Arno and Halle, Martin and Kotliar, Konstantin}, title = {Dynamic retinal vessel response to flicker in age-related macular degeneration patients before and after vascular endothelial growth factor inhibitor injection}, series = {Acta Ophthalmologica}, volume = {89}, journal = {Acta Ophthalmologica}, number = {5}, publisher = {Wiley}, address = {Weinheim}, isbn = {1755-3768}, pages = {472 -- 479}, year = {2011}, language = {en} } @article{KurulganDemirciLinderDemircietal.2009, author = {Kurulgan Demirci, Eylem and Linder, Peter and Demirci, Taylan and Trzewik, J{\"u}rgen and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Contractile tension of endothelial cells: An LPS based in-vitro sepsis model}, series = {IUBMB Life. 61 (2009), H. 3}, journal = {IUBMB Life. 61 (2009), H. 3}, publisher = {Wiley}, address = {Weinheim}, isbn = {1521-6543}, pages = {307 -- 308}, year = {2009}, language = {en} } @article{Pieper2011, author = {Pieper, Martin}, title = {Multiobjective optimization with expensive objectives applied to a thermodynamic material design problem}, series = {Proceedings in applied mathematics and mechanics : PAMM. 11 (2011), H. 1}, journal = {Proceedings in applied mathematics and mechanics : PAMM. 11 (2011), H. 1}, publisher = {Wiley}, address = {Weinheim}, isbn = {1617-7061}, pages = {733 -- 734}, year = {2011}, language = {en} } @article{JahnkeMenzelDusschotenetal.2009, author = {Jahnke, Siegfried and Menzel, Marion I. and Dusschoten, Dagmar van and Roeb, Gerhard W. and B{\"u}hler, Jonas and Minwuyelet, Senay and Bl{\"u}mler, Peter and Temperton, Vicky M. and Hombach, Thomas and Streun, Matthias and Beer, Simone and Khodaverdi, Maryam and Ziemons, Karl and Coenen, Heinz H. and Schurr, Ulrich}, title = {Combined MRI-PET dissects dynamic changes in plant structures and functions}, series = {The Plant Journal}, volume = {59}, journal = {The Plant Journal}, number = {4}, publisher = {Wiley}, address = {Weinheim}, isbn = {1365-313X}, pages = {634 -- 644}, year = {2009}, abstract = {Unravelling the factors determining the allocation of carbon to various plant organs is one of the great challenges of modern plant biology. Studying allocation under close to natural conditions requires non-invasive methods, which are now becoming available for measuring plants on a par with those developed for humans. By combining magnetic resonance imaging (MRI) and positron emission tomography (PET), we investigated three contrasting root/shoot systems growing in sand or soil, with respect to their structures, transport routes and the translocation dynamics of recently fixed photoassimilates labelled with the short-lived radioactive carbon isotope 11C. Storage organs of sugar beet (Beta vulgaris) and radish plants (Raphanus sativus) were assessed using MRI, providing images of the internal structures of the organs with high spatial resolution, and while species-specific transport sectoralities, properties of assimilate allocation and unloading characteristics were measured using PET. Growth and carbon allocation within complex root systems were monitored in maize plants (Zea mays), and the results may be used to identify factors affecting root growth in natural substrates or in competition with roots of other plants. MRI-PET co-registration opens the door for non-invasive analysis of plant structures and transport processes that may change in response to genomic, developmental or environmental challenges. It is our aim to make the methods applicable for quantitative analyses of plant traits in phenotyping as well as in understanding the dynamics of key processes that are essential to plant performance.}, language = {en} } @article{MuribGrinsvenGrietenetal.2013, author = {Murib, M. S. and Grinsven, B. van and Grieten, L. and Janssens, S. D. and Vermeeren, V. and Eersels, K. and Broeders, J. and Ameloot, M. and Michiels, L. and Ceuninck, W. De and Haenen, K. and Sch{\"o}ning, Michael Josef and Wagner, Patrick}, title = {Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates}, series = {Physica Status Solidi (A). Vol. 210 (2013), iss. 5}, journal = {Physica Status Solidi (A). Vol. 210 (2013), iss. 5}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {0031-8965}, pages = {911 -- 917}, year = {2013}, language = {en} } @article{JensKaldenhoffKirschnerHermannsetal.2014, author = {Jens, Otto and Kaldenhoff, E. and Kirschner-Hermanns, R. and M{\"u}hl, Thomas and Klinge, Uwe}, title = {Elongation of textile pelvic floor implants under load is related to complete loss of effective porosity, thereby favoring incorporation in scar plates}, series = {Journal of biomedical materials research. Part A}, volume = {102}, journal = {Journal of biomedical materials research. Part A}, number = {4}, publisher = {Wiley}, address = {New York}, issn = {1552-4965}, doi = {10.1002/jbm.a.34767}, pages = {1079 -- 1084}, year = {2014}, abstract = {Use of textile structures for reinforcement of pelvic floor structures has to consider mechanical forces to the implant, which are quite different to the tension free conditions of the abdominal wall. Thus, biomechanical analysis of textile devices has to include the impact of strain on stretchability and effective porosity. Prolift® and Prolift + M®, developed for tension free conditions, were tested by measuring stretchability and effective porosity applying mechanical strain. For comparison, we used Dynamesh-PR4®, which was designed for pelvic floor repair to withstand mechanical strain. Prolift® at rest showed moderate porosity with little stretchability but complete loss of effective porosity at strain of 4.9 N/cm. Prolift + M® revealed an increased porosity at rest, but at strain showed high stretchability, with subsequent loss of effective porosity at strain of 2.5 N/cm. Dynamesh PR4® preserved its high porosity even under strain, but as consequence of limited stretchability. Though in tension free conditions Prolift® and Prolift + M® can be considered as large pore class I meshes, application of mechanical strain rapidly lead to collapse of pores. The loss of porosity at mechanical stress can be prevented by constructions with high structural stability. Assessment of porosity under strain was found helpful to define requirements for pelvic floor devices. Clinical studies have to prove whether devices with high porosity as well as high structural stability can improve the patients' outcome.}, language = {en} } @article{MukherjeeRamazaniYangetal.2011, author = {Mukherjee, Krishnendu and Ramazani, Ali and Yang, Li and Prahl, Ulrich and Bleck, Wolfgang and Reisgen, Uwe and Schleser, Markus and Abdurakhmanov, Aydemir}, title = {Characterization of gas metal arc welded hot rolled DP600 steel}, series = {Steel research international}, volume = {Vol. 82}, journal = {Steel research international}, number = {Iss. 12}, publisher = {Wiley}, address = {Weinheim}, issn = {1869-344X (E-Book); 1611-3683 (Print)}, pages = {1408 -- 1416}, year = {2011}, language = {en} } @article{BongaertsEsserLorbachetal.2011, author = {Bongaerts, Johannes and Esser, Simon and Lorbach, Volker and Al-Momani, L{\´o}ay and M{\"u}ller, Michael A. and Franke, Dirk and Grondal, Christoph and Kurutsch, Anja and Bujnicki, Robert and Takors, Ralf and Raeven, Leon and Wubbolts, Marcel and Bovenberg, Roel and Nieger, Martin and Sch{\"u}rmann, Melanie and Trachtmann, Natalie and Kozak, Stefan and Sprenger, Georg A. and M{\"u}ller, Michael}, title = {Diversity-oriented production of metabolites derived from chorismate and their use in organic synthesis}, series = {Angewandte Chemie International Edition}, volume = {Vol. 50}, journal = {Angewandte Chemie International Edition}, number = {Iss. 34}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-3773 (E-Journal); 0570-0833 (Print); 1433-7851 (Print)}, pages = {7781 -- 7786}, year = {2011}, language = {en} } @article{VoigtSchroeterJuergenetal.2013, author = {Voigt, Birgit and Schroeter, Rebecca and J{\"u}rgen, Britta and Albrecht, Dirk and Evers, Stefan and Bongaerts, Johannes and Maurer, Karl-Heinz and Schweder, Thomas and Hecker, Michael}, title = {The response of Bacillus licheniformis to heat and ethanol stress and the role of the SigB regulon}, series = {Proteomics}, volume = {Vol. 13}, journal = {Proteomics}, number = {Iss. 14}, publisher = {Wiley}, address = {Weinheim}, issn = {1615-9861 (E-Journal); 1615-9853 (Print)}, pages = {2140 -- 2146}, year = {2013}, language = {en} } @article{HeinzeMangPeteretal.2014, author = {Heinze, Daniel and Mang, Thomas and Peter, Karin and M{\"o}ller, Martin and Weichold, Oliver}, title = {Synthesis of low molecular weight poly(vinyl acetate) and its application as plasticizer}, series = {Journal of applied polymer science}, volume = {131}, journal = {Journal of applied polymer science}, number = {9}, publisher = {Wiley}, address = {New York}, issn = {1097-4628 (E-Journal); 0021-8995 (Print)}, doi = {10.1002/app.40226}, pages = {Article No. 40226}, year = {2014}, abstract = {Poly(vinyl acetate), PVAc, with a degree of polymerization Xn = 10 was prepared by chain-transfer radical polymerization using carbon tetrachloride and used as oligomeric plasticizer for commercial PVAc. However, the chlorinated chain ends cause a low thermal stability requiring mild Cl/H substitution. The product exhibits high thermal stability and excellent melt-compounding properties. Blends of oligomeric and commercial PVAc show single glass transition temperatures which decrease with higher oligomer content and exhibit small negative deviations from Fox' linear additivity rule. This indicates plasticization and miscibility being mainly due to entropic effects. Injection-moulded thick specimens show ductile behaviour at oligomer contents >10 wt \%, while sheets with a thickness of 0.2-0.5 mm appear flexible already at 7.5 wt \%. The oxygen permeability coefficients are an order of magnitude lower than those of low-density polyethylene. Due to the sum of their properties, the plasticized sheets present a promising alternative in the preparation of barrier materials.}, language = {en} } @article{HeggerClassenSchaumannetal.2013, author = {Hegger, Josef and Claßen, Martin and Schaumann, Peter and Sothmann, J{\"o}rg and Feldmann, Markus and D{\"o}ring, Bernd}, title = {Entwicklung einer integrierten Verbunddecke f{\"u}r nachhaltige Stahlbauten}, series = {Stahlbau}, volume = {Vol. 82}, journal = {Stahlbau}, number = {Iss. 1}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1049 (E-Journal); 0038-9145 (Print)}, pages = {11 -- 17}, year = {2013}, language = {de} } @article{HeggerClassenFeldmannetal.2011, author = {Hegger, Josef and Claßen, Martin and Feldmann, Markus and D{\"o}ring, Bernd and Schaumann, Peter and Sothmann, J{\"o}rg and Bohne, Dirk and Hargus, Steen and Barben, Daniel and Aarden, Erik and Schielke, Sabine}, title = {Integrierte und nachhaltigkeitsorientierte Deckensysteme im Stahl- und Verbundbau}, series = {Stahlbau}, volume = {Vol. 80}, journal = {Stahlbau}, number = {Iss. 10}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1049 (E-Journal); 0038-9145 (Print)}, pages = {728 -- 733}, year = {2011}, language = {de} } @article{DoeringFeldmannKuhnhenneetal.2011, author = {D{\"o}ring, Bernd and Feldmann, Markus and Kuhnhenne, Markus and M{\"u}ller, Dirk}, title = {Phasenwechselmaterial im Metallleichtbau zur Optimierung von Energieeffizienz und sommerlicher Raumtemperatur}, series = {Stahlbau}, volume = {Vol. 80}, journal = {Stahlbau}, number = {Iss. 9}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1049 (E-Journal); 0038-9145 (Print)}, pages = {666 -- 672}, year = {2011}, language = {de} } @article{DoeringFeldmannKuhnhenne2009, author = {D{\"o}ring, Bernd and Feldmann, Markus and Kuhnhenne, Markus}, title = {Der Beitrag von Profilblechdecken zur passiven K{\"u}hlung}, series = {Bauphysik}, volume = {Vol. 31}, journal = {Bauphysik}, number = {Iss. 2}, publisher = {Wiley}, address = {Weinheim}, isbn = {1437-0980 (E-Journal); 0171-5445 (Print)}, pages = {65 -- 71}, year = {2009}, language = {de} } @article{JiminezGermanBehbahaniMiettinenetal.2013, author = {Jiminez German, Salvador and Behbahani, Mehdi and Miettinen, Susanna and Grijpma, Dirk W. and Haimi, Suvi P.}, title = {Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes}, series = {Macromolecular symposia}, volume = {Vol. 334}, journal = {Macromolecular symposia}, number = {Iss. 1}, publisher = {Wiley}, address = {Weinheim}, issn = {0258-0322}, pages = {133 -- 142}, year = {2013}, language = {en} } @article{WangDruckenmuellerElbersetal.2014, author = {Wang, Ren-Qi and Druckenm{\"u}ller, Katharina and Elbers, Gereon and Guenther, Klaus and Crou{\´e}, Jean-Philippe}, title = {Analysis of aquatic-phase natural organic matter by optimized LDI-MS method}, series = {Journal of mass spectrometry}, volume = {49}, journal = {Journal of mass spectrometry}, number = {2}, publisher = {Wiley}, address = {Bognor Regis}, issn = {1096-9888}, doi = {10.1002/jms.3321}, pages = {154 -- 160}, year = {2014}, abstract = {The composition and physiochemical properties of aquatic-phase natural organic matter (NOM) are most important problems for both environmental studies and water industry. Laser desorption/ionization (LDI) mass spectrometry facilitated successful examinations of NOM, as humic and fulvic acids in NOM are readily ionized by the nitrogen laser. In this study, hydrophobic NOMs (HPO NOMs) from river, reservoir and waste water were characterized by this technique. The effect of analytical variables like concentration, solvent composition and laser energy was investigated. The exact masses of small molecular NOM moieties in the range of 200-1200 m/z were determined in reflectron mode. In addition, spectra of post-source-decay experiments in this range showed that some compounds from different natural NOMs had the same fragmental ions. In the large mass range of 1200-15 000 Da, macromolecules and their aggregates were found in HPO NOMs from natural waters. Highly humic HPO exhibited mass peaks larger than 8000 Da. On the other hand, the waste water and reservoir water mainly had relatively smaller molecules of about 2000 Da. The LDI-MS measurements indicated that highly humic river waters were able to form large aggregates and membrane foulants, while the HPO NOMs from waste water and reservoir water were unlikely to form large aggregates. Copyright © 2014 John Wiley \& Sons, Ltd.}, language = {en} } @article{MartinezJakobTuetal.2013, author = {Martinez, Ronny and Jakob, Felix and Tu, Ran and Siegert, Petra and Maurer, Karl-Heinz and Schwaneberg, Ulrich}, title = {Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution}, series = {Biotechnology and bioengineering}, volume = {Vol. 110}, journal = {Biotechnology and bioengineering}, number = {Iss. 3}, publisher = {Wiley}, address = {Weinheim}, issn = {1097-0290 (E-Journal); 0006-3592 (Print); 0368-1467 (Print)}, pages = {711 -- 720}, year = {2013}, language = {en} } @article{RibitschHeumannTrotschaetal.2011, author = {Ribitsch, D. and Heumann, S. and Trotscha, E. and Herrero Acero, E. and Greimel, K. and Leber, R. and Birger-Gruenberger, R. and Deller, S. and Eiteljoerg, I. and Remler, P. and Weber, Th. and Siegert, Petra and Maurer, Karl-Heinz and Donelli, I. and Freddi, G. and Schwab, H. and Guebitz, G. M.}, title = {Hydrolysis of polyethyleneterephthalate by p-nitrobenzylesterase from Bacillus subtilis}, series = {Biotechnology progress}, volume = {Vol. 27}, journal = {Biotechnology progress}, number = {Iss. 4}, publisher = {Wiley}, address = {Hoboken}, issn = {1520-6033 (E-Journal); 8756-7938 (Print)}, pages = {951 -- 960}, year = {2011}, language = {en} } @article{BaeckerSchusserPoghossianetal.2014, author = {B{\"a}cker, Matthias and Schusser, Sebastian and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Multi-Parametererfassung mit siliziumbasiertem Sensorchip: Aus Drei mach Eins}, series = {GIT Labor-Fachzeitschrift}, journal = {GIT Labor-Fachzeitschrift}, number = {2}, publisher = {Wiley}, issn = {0016-3538}, pages = {28 -- 30}, year = {2014}, language = {de} } @article{BegingLeinhosJablonskietal.2015, author = {Beging, Stefan and Leinhos, Marcel and Jablonski, Melanie and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Studying the spatially resolved immobilisation of enzymes on a capacitive field-effect structure by means of nano-spotting}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431891}, pages = {1353 -- 1358}, year = {2015}, language = {en} } @article{OberlaenderBrommWendeleretal.2015, author = {Oberl{\"a}nder, Jan and Bromm, Alexander and Wendeler, Luisa and Iken, Heiko and Palomar Duran, Marlena and Greeff, Anton and Kirchner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards a biosensor to monitor the sterilisation efficiency of aseptic filling machines}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431900}, pages = {1299 -- 1305}, year = {2015}, abstract = {Sterilisation processes are compulsory in medicine, pharmacy, and food industries to prevent infections of consumers and microbiological contaminations of products. Monitoring the sterilisation by conventional microbiological methods is time- and lab-consuming. To overcome this problem, in this work a novel biosensor has been proposed. The sensor enables a fast method to evaluate sterilisation processes. By means of thin-film technology the sensor's transducer structures in form of IDEs (interdigitated electrodes) have been fabricated on a silicon substrate. Physical characterisation of the developed sensor was done by AFM, SEM, and profilometry. Impedance analyses were conducted for the electrical characterisation. As microbiological layer spores of B. atrophaeus have been immobilised on the sensing structure; spores of this type are a well-known sterilisation test organism. Impedance measurements at a fixed frequency over time were performed to monitor the immobilisation process. A sterilisation process according to aseptic filling machines was applied to demonstrate the sensor functionality. After both, immobilisation and sterilisation, a change in impedance could successfully be detected.}, language = {en} } @article{HuckPoghossianBaeckeretal.2015, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Reisert, Steffen and Kramer, Friederike and Begoyan, Vardges K. and Buniatyan, Vahe V. and Sch{\"o}ning, Michael Josef}, title = {Multi-parameter sensing using high-k oxide of barium strontium titanate}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431911}, pages = {1259}, year = {2015}, abstract = {High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors. In this work, a Si-based sensor chip containing Pt interdigitated electrodes covered with a thin BST layer (485 nm) has been developed for multi-parameter chemical sensing. The chip has been applied for the contactless measurement of the electrolyte conductivity, the detection of adsorbed charged macromolecules (positively charged polyelectrolytes of polyethylenimine) and the concentration of hydrogen peroxide (H2O2) vapor. The experimental results of functional testing of individual sensors are presented. The mechanism of the BST sensitivity to charged polyelectrolytes and H2O2 vapor has been proposed and discussed.}, language = {en} } @article{JildehWagnerSchoeningetal.2015, author = {Jildeh, Zaid B. and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Pieper, Martin}, title = {Simulating the electromagnetic-thermal treatment of thin aluminium layers for adhesion improvement}, series = {Physica status solidi (a)}, volume = {Vol. 212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431893}, pages = {1234 -- 1241}, year = {2015}, abstract = {A composite layer material used in packaging industry is made from joining layers of different materials using an adhesive. An important processing step in the production of aluminium-containing composites is the surface treatment and consequent coating of adhesive material on the aluminium surface. To increase adhesion strength between aluminium layer and the adhesive material, the foil is heat treated. For efficient heating, induction heating was considered as state-of-the-art treatment process. Due to the complexity of the heating process and the unpredictable nature of the heating source, the control of the process is not yet optimised. In this work, a finite element analysis of the process was established and various process parameters were studied. The process was simplified and modelled in 3D. The numerical model contains an air domain, an aluminium layer and a copper coil fitted with a magnetic field concentrating material. The effect of changing the speed of the aluminium foil (or rolling speed) was studied with the change of the coil current. Statistical analysis was used for generating a general control equation of coil current with changing rolling speed.}, language = {en} } @article{PilasIkenSelmeretal.2015, author = {Pilas, Johanna and Iken, Heiko and Selmer, Thorsten and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Development of a multi-parameter sensor chip for the simultaneous detection of organic compounds in biogas processes}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431894}, pages = {1306 -- 1312}, year = {2015}, abstract = {An enzyme-based multi-parameter biosensor is developed for monitoring the concentration of formate, d-lactate, and l-lactate in biological samples. The sensor is based on the specific dehydrogenation by an oxidized β-nicotinamide adenine dinucleotide (NAD+)-dependent dehydrogenase (formate dehydrogenase, d-lactic dehydrogenase, and l-lactic dehydrogenase, respectively) in combination with a diaphorase from Clostridium kluyveri (EC 1.8.1.4). The enzymes are immobilized on a platinum working electrode by cross-linking with glutaraldehyde (GA). The principle of the determination scheme in case of l-lactate is as follows: l-lactic dehydrogenase (l-LDH) converts l-lactate into pyruvate by reaction with NAD+. In the presence of hexacyanoferrate(III), the resulting reduced β-nicotinamide adenine dinucleotide (NADH) is then regenerated enzymatically by diaphorase. The electrochemical detection is based on the current generated by oxidation of hexacyanoferrate(II) at an applied potential of +0.3 V vs. an Ag/AgCl reference electrode. The biosensor will be electrochemically characterized in terms of linear working range and sensitivity. Additionally, the successful practical application of the sensor is demonstrated in an extract from maize silage.}, language = {en} } @article{BreuerRaueKirschbaumetal.2015, author = {Breuer, Lars and Raue, Markus and Kirschbaum, M. and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, R. and Wagner, Torsten}, title = {Light-controllable polymeric material based on temperature-sensitive hydrogels with incorporated graphene oxide}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431944}, pages = {1368 -- 1374}, year = {2015}, abstract = {Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel films with incorporated graphene oxide (GO) were developed and tested as light-stimulated actuators. GO dispersions were synthesized via Hummers method and characterized toward their optical properties and photothermal energy conversion. The hydrogels were prepared by means of photopolymerization. In addition, the influence of GO within the hydrogel network on the lower critical solution temperature (LCST) was investigated by differential scanning calorimetry (DSC). The optical absorbance and the response to illumination were determined as a function of GO concentration for thin hydrogel films. A proof of principle for the stimulation with light was performed.}, language = {en} } @article{KotliarKharoubiSchmidtTrucksaessetal.2009, author = {Kotliar, Konstantin and Kharoubi, A. and Schmidt-Trucks{\"a}ß, A. and Halle, M. and Lanzl, I.}, title = {Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons?}, series = {Acta Ophthalmologica}, volume = {Vol. 87}, journal = {Acta Ophthalmologica}, number = {Suppl. S244}, publisher = {Wiley}, address = {Weinheim}, issn = {1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print)}, pages = {0}, year = {2009}, language = {en} } @article{SchiffelsSelmer2015, author = {Schiffels, Johannes and Selmer, Thorsten}, title = {A flexible toolbox to study protein-assisted metalloenzyme assembly in vitro}, series = {Biotechnology and Bioengineering}, volume = {112}, journal = {Biotechnology and Bioengineering}, number = {11}, publisher = {Wiley}, address = {Weinheim}, issn = {1097-0290}, doi = {10.1002/bit.25658}, pages = {2360 -- 2372}, year = {2015}, language = {en} } @article{VoigtAlbrechtSieversetal.2015, author = {Voigt, Birgit and Albrecht, Dirk and Sievers, Susanne and Becher, D{\"o}rte and Bongaerts, Johannes and Evers, Stefan and Schweder, Thomas and Maurer, Karl-Heinz and Hecker, Michael}, title = {High-resolution proteome maps of Bacillus licheniformis cells growing in minimal medium}, series = {Proteomics}, volume = {15}, journal = {Proteomics}, number = {15}, publisher = {Wiley}, address = {Weinheim}, issn = {1615-9861}, doi = {10.1002/pmic.201400504}, pages = {2629 -- 2633}, year = {2015}, language = {en} } @article{TakenagaSchneiderErbayetal.2015, author = {Takenaga, Shoko and Schneider, Benno and Erbay, E. and Biselli, Manfred and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201532053}, pages = {1347 -- 1352}, year = {2015}, abstract = {A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.}, language = {en} } @article{MolinnusBaeckerIkenetal.2015, author = {Molinnus, Denise and B{\"a}cker, Matthias and Iken, Heiko and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Concept for a biomolecular logic chip with an integrated sensor and actuator function}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431913}, pages = {1382 -- 1388}, year = {2015}, abstract = {A concept for a new generation of an integrated multi-functional biosensor/actuator system is developed, which is based on biomolecular logic principles. Such a system is expected to be able to detect multiple biochemical input signals simultaneously and in real-time and convert them into electrical output signals with logical operations such as OR, AND, etc. The system can be designed as a closed-loop drug release device triggered by an enzyme logic gate, while the release of the drug induced by the actuator at the required dosage and timing will be controlled by an additional drug sensor. Thus, the system could help to make an accurate and specific diagnosis. The presented concept is exemplarily demonstrated by using an enzyme logic gate based on a glucose/glucose oxidase system, a temperature-responsive hydrogel mimicking the actuator function and an insulin (drug) sensor. In this work, the results of functional testing of individual amperometric glucose and insulin sensors as well as an impedimetric sensor for the detection of the hydrogel swelling/shrinking are presented.}, language = {en} } @article{DelleHuckBaeckeretal.2015, author = {Delle, Lotta E. and Huck, Christina and B{\"a}cker, Matthias and M{\"u}ller, Frank and Grandthyll, Samuel and Jacobs, Karin and Lilischkis, Rainer and Vu, Xuan T. and Sch{\"o}ning, Michael Josef and Wagner, Patrick and Thoelen, Roland and Weil, Maryam and Ingebrandt, Sven}, title = {Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431863}, pages = {1327 -- 1334}, year = {2015}, language = {en} } @article{KuertenMottaghyZiegler2015, author = {K{\"u}rten, Sylvia and Mottaghy, Darius and Ziegler, Martin}, title = {Besonderheiten bei der Planung und Berechnung von oberfl{\"a}chennahen thermo-aktiven Bauteilen}, series = {Geotechnik}, volume = {38}, journal = {Geotechnik}, number = {2}, publisher = {Wiley}, address = {Weinheim}, issn = {2190-6653}, doi = {10.1002/gete.201500002}, pages = {107 -- 119}, year = {2015}, language = {de} } @article{ButenwegGellert2012, author = {Butenweg, Christoph and Gellert, Christoph}, title = {Integrale Geb{\"a}udeplanung am Beispiel eines Geschossbaus in Ziegelmauerwerk}, series = {Mauerwerk : European journal of masonry}, volume = {Volume 16}, journal = {Mauerwerk : European journal of masonry}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1022 (E-Journal); 1432-3427 (Print)}, doi = {10.1002/dama.201200550}, pages = {247 -- 254}, year = {2012}, abstract = {Moderne Mauerwerksbauten m{\"u}ssen nach heutigen Anforderungen architektonisch, statisch, energetisch sowie schall- und brandschutztechnisch optimal ausgelegt sein. Aufgrund der Komplexit{\"a}t und engen Verzahnung der einzelnen Anforderungen ist eine integrale Geb{\"a}udeplanung zur Erzielung einer qualitativ hochwertigen Bauwerksl{\"o}sung unbedingt notwendig. Diese erfordert von den Fachplanern vertieftes Spezialwissen in den verschiedenen Bereichen, um insbesondere die Schnittstellen und Bauwerksdetails korrekt zu planen und auszuf{\"u}hren. Der Beitrag stellt die integrale Geb{\"a}udeplanung am Beispiel eines Geschossbaus in Ziegelbauweise mit L{\"o}sungen f{\"u}r wesentliche Detailpunkte vor}, language = {de} } @article{ButenwegGellert2013, author = {Butenweg, Christoph and Gellert, Christoph}, title = {Nichtlinearer Nachweis von Mauerwerksbauten}, series = {Mauerwerk : European journal of masonry}, volume = {Volume 17}, journal = {Mauerwerk : European journal of masonry}, number = {Issue 3}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1022 (E-Journal); 1432-3427 (Print)}, doi = {10.1002/dama.201300575}, pages = {166 -- 171}, year = {2013}, language = {de} } @article{TaddeiButenwegKlinkel2015, author = {Taddei, Francesca and Butenweg, Christoph and Klinkel, S.}, title = {Parametric investigation of the soil-structure interaction effects on the dynamic behaviour of a shallow foundation supported wind turbine considering a layered soil}, series = {Wind energy : an international journal for progress and applications in wind power conversion technology}, volume = {Volume 18}, journal = {Wind energy : an international journal for progress and applications in wind power conversion technology}, number = {Issue 3}, publisher = {Wiley}, address = {Weinheim}, issn = {1099-1824 (E-Journal); 1095-4244 (Print)}, doi = {10.1002/we.1703}, pages = {399 -- 417}, year = {2015}, language = {en} } @article{ButenwegFehling2012, author = {Butenweg, Christoph and Fehling, Ekkehard}, title = {Hintergrund f{\"u}r die vereinfachten Regeln bei Mauerwerksgeb{\"a}uden im Erdbebenfall}, series = {Mauerwerk : European journal of masonry}, volume = {Volume 16}, journal = {Mauerwerk : European journal of masonry}, number = {Issue 3}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1022 (E-Journal); 1432-3427 (Print)}, doi = {10.1002/dama.201200537}, pages = {127 -- 137}, year = {2012}, abstract = {Bei der Ausarbeitung des nationalen Anwendungsdokumentes zur DIN EN 1998-1 waren die in der ENV-Fassung enthaltenen vereinfachten Regeln im Lichte aktueller Forschungsergebnisse zu {\"u}berpr{\"u}fen und zu {\"u}berarbeiten. Die gleiche Aufgabe stellte sich auch f{\"u}r die Neufassung der DIN 4149. In beiden F{\"a}llen sind neben konstruktiven Regeln f{\"u}r die Art und Anordnung der zur Geb{\"a}udeaussteifung heranzuziehenden W{\"a}nde im Grundriss Tabellen enthalten, die unter bestimmten Bedingungen den Entfall eines rechnerischen Nachweises der Tragw{\"a}nde im Erdbebenfall erm{\"o}glichen. Dies ist f{\"u}r Schwachbebengebiete, wie sie in Deutschland und anderen L{\"a}ndern Mitteleuropas anzutreffen sind, sinnvoll, um unn{\"o}tigen Rechenaufwand sowie Probleme mit der F{\"u}hrbarkeit von Nachweisen so weit wie m{\"o}glich auszuschalten. Im vorliegenden Beitrag werden die Hintergr{\"u}nde der vereinfachten Regeln diskutiert und die Ergebnisse der Anwendung mit verschiedenen Rechenverfahren verglichen und bewertet.}, language = {de} } @article{LaumannMainz2012, author = {Laumann, J{\"o}rg and Mainz, Stefan}, title = {Direkte Ermittlung der erforderlichen Einspanntiefe von I‑f{\"o}rmigen Stahlquerschnitten in Betonkonstruktionen}, volume = {81}, number = {11}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1049}, doi = {10.1002/stab.201201620}, pages = {850 -- 860}, year = {2012}, abstract = {F{\"u}r die Ermittlung der erforderlichen Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen existieren verschiedene Bemessungsmodelle. Diese basieren vorwiegend auf Grundlage nationaler Normen wie z. B. DIN 18800 [1] und DIN 1045 [2], die durch die europ{\"a}ische Normung ersetzt wurden. Aus diesem Grund wird in diesem Aufsatz ein Berechnungsmodell f{\"u}r die erforderliche Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen auf Grundlage des Eurocodes vorgestellt. Das Grundger{\"u}st f{\"u}r dieses Berechnungsmodell bildet das Verfahren nach Kindmann und Laumann, welches in [3] behandelt wurde. Gleichzeitig werden neue Formeln zur direkten Ermittlung der Mindesteinspanntiefe vorgestellt. Behandelt werden gewalzte I-Profile f{\"u}r einachsige Biegung um die starke Achse (y-y) mit Drucknormalkraft.}, language = {de} } @article{KubalskiButenweg2015, author = {Kubalski, Thomas and Butenweg, Christoph}, title = {Modelling strategies for horizontally loaded infill masonry}, series = {Mauerwerk : European journal of masonry}, volume = {Volume 19}, journal = {Mauerwerk : European journal of masonry}, number = {Issue 5}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/dama.201500675}, pages = {363 -- 369}, year = {2015}, language = {de} } @article{BankOrzadaSmitsetal.2015, author = {Bank, Bart L. van de and Orzada, Stephan and Smits, Frits and Lagemaat, Miriam W. and Rodgers, Christopher T. and Bitz, Andreas and Scheenen, Tom W. J.}, title = {Optimized (31) P MRS in the human brain at 7 T with a dedicated RF coil setup}, series = {NMR in Biomedicine}, volume = {28}, journal = {NMR in Biomedicine}, number = {11}, publisher = {Wiley}, address = {Weinheim}, issn = {1099-1492}, doi = {10.1002/nbm.3422}, pages = {1570 -- 1578}, year = {2015}, language = {en} } @article{LagemaatMaasVosetal.2015, author = {Lagemaat, Miriam W. and Maas, Marnix C. and Vos, Eline K. and Bitz, Andreas and Orzada, Stephan and Weiland, Elisabeth and Uden, Mark J. van and Kobus, Thiele and Heerschap, Arend and Scheenen, Tom W. J.}, title = {(31) P MR spectroscopic imaging of the human prostate at 7 T: T1 relaxation times, Nuclear Overhauser Effect, and spectral characterization}, series = {Magnetic Resonance in Medicine}, volume = {73}, journal = {Magnetic Resonance in Medicine}, number = {3}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2594}, doi = {10.1002/mrm.25209}, pages = {909 -- 920}, year = {2015}, language = {en} } @article{NoureddineKraffLaddetal.2017, author = {Noureddine, Yacine and Kraff, Oliver and Ladd, Mark E. and Wrede, Karsten H. and Chen, Bixia and Quick, Harald H. and Schaefers, Gregor and Bitz, Andreas}, title = {In vitro and in silico assessment of RF-induced heating around intracranial aneurysm clips at 7 Tesla}, series = {Magnetic Resonance in Medicine}, journal = {Magnetic Resonance in Medicine}, number = {Early view}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2594}, doi = {10.1002/mrm.26650}, pages = {14 Seiten}, year = {2017}, language = {en} } @article{AlexopoulosHoffschmidt2017, author = {Alexopoulos, Spiros and Hoffschmidt, Bernhard}, title = {Advances in solar tower technology}, series = {Wiley interdisciplinary reviews : Energy and Environment : WIREs}, volume = {6}, journal = {Wiley interdisciplinary reviews : Energy and Environment : WIREs}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {2041-840X}, doi = {10.1002/wene.217}, pages = {1 -- 19}, year = {2017}, language = {en} } @article{KraffWredeSchoembergetal.2013, author = {Kraff, Oliver and Wrede, Karsten H. and Schoemberg, Tobias and Dammann, Philipp and Noureddine, Yacine and Orzada, Stephan and Ladd, Mark E. and Bitz, Andreas}, title = {MR safety assessment of potential RF heating from cranial fixation plates at 7 T}, series = {Medical Physics}, volume = {40}, journal = {Medical Physics}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {2473-4209}, doi = {10.1118/1.4795347}, pages = {042302-1 -- 042302-10}, year = {2013}, language = {en} } @article{OrzadaJohstMaderwaldetal.2013, author = {Orzada, Stephan and Johst, S{\"o}ren and Maderwald, Stefan and Bitz, Andreas and Solbach, Klaus and Ladd, Mark E.}, title = {Mitigation of B1(+) inhomogeneity on single-channel transmit systems with TIAMO}, series = {Magnetic Resonance in Medicine}, volume = {70}, journal = {Magnetic Resonance in Medicine}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2594}, doi = {10.1002/mrm.24453}, pages = {290 -- 294}, year = {2013}, language = {en} } @article{OrzadaBitzSchaeferetal.2011, author = {Orzada, Stephan and Bitz, Andreas and Sch{\"a}fer, Lena C. and Ladd, Susanne C. and Ladd, Mark E. and Maderwald, Stefan}, title = {Open design eight-channel transmit/receive coil for high-resolution and real-time ankle imaging at 7 T}, series = {Medical Physics}, volume = {38}, journal = {Medical Physics}, number = {3}, publisher = {Wiley}, address = {Hoboken}, issn = {2473-4209}, doi = {10.1118/1.3553399}, pages = {1162 -- 1167}, year = {2011}, abstract = {Purpose: At 1.5 T, real-time MRI of joint movement has been shown to be feasible. However, 7 T, provides higher SNR and thus an improved potential for parallel imaging acceleration. The purpose of this work was to build an open, U-shaped eight-channel transmit/receive microstrip coil for 7 T MRI to enable high-resolution and real-time imaging of the moving ankle joint. Methods: A U-shaped eight-channel transmit/receive array for the human ankle was built.urn:x-wiley:00942405:mp3399:equation:mp3399-math-0001-parameters and urn:x-wiley:00942405:mp3399:equation:mp3399-math-0002-factor were measured. SAR calculations of different ankle postures were performed to ensure patient safety. Inhomogeneities in the transmit field consequent to the open design were compensated for by the use of static RF shimming. High-resolution and real-time imaging was performed in human volunteers. Results: The presented array showed good performance with regard to patient comfort and image quality. High acceleration factors of up to 4 are feasible without visible acceleration artifacts. Reasonable image homogeneity was achieved with RF shimming. Conclusions: Open, noncylindrical designs for transmit/receive coils are practical at 7 T and real-time imaging of the moving joint is feasible with the presented coil design.}, language = {en} } @article{CiritsisHorbachStaatetal.2018, author = {Ciritsis, Alexander and Horbach, Andreas and Staat, Manfred and Kuhl, Christiane K. and Kraemer, Nils Andreas}, title = {Porosity and tissue integration of elastic mesh implants evaluated in vitro and in vivo}, series = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials}, volume = {106}, journal = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials}, number = {2}, publisher = {Wiley}, address = {New York, NY}, issn = {1552-4981}, doi = {10.1002/jbm.b.33877}, pages = {827 -- 833}, year = {2018}, abstract = {Purpose In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model. Material and Methods Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro. A group of three pigs each were treated with magnetic resonance imaging (MRI) visible conventional stiff polyvinylidene fluoride meshes (PVDF) or with soft thermoplastic polyurethane meshes (TPU) (FEG Textiltechnik mbH, Aachen, Germany), respectively. MRI was performed with a pneumoperitoneum at a pressure of 0 and 15 mmHg, which resulted in bulging of the abdomen. The mesh-induced signal voids were semiautomatically segmented and the mesh areas were determined. With the deformations assessed in both mesh types at both pressure conditions, the porosity change of the meshes after 8 weeks of ingrowth was calculated as an indicator of preserved elastic properties. The explanted specimens were examined histologically for the maturity of the scar (collagen I/III ratio). Results In TPU, the in vitro porosity increased constantly, in PVDF, a loss of porosity was observed under mild stresses. In vivo, the mean mesh areas of TPU were 206.8 cm2 (± 5.7 cm2) at 0 mmHg pneumoperitoneum and 274.6 cm2 (± 5.2 cm2) at 15 mmHg; for PVDF the mean areas were 205.5 cm2 (± 8.8 cm2) and 221.5 cm2 (± 11.8 cm2), respectively. The pneumoperitoneum-induced pressure increase resulted in a calculated porosity increase of 8.4\% for TPU and of 1.2\% for PVDF. The mean collagen I/III ratio was 8.7 (± 0.5) for TPU and 4.7 (± 0.7) for PVDF. Conclusion The elastic properties of TPU mesh implants result in improved tissue integration compared to conventional PVDF meshes, and they adapt more efficiently to the abdominal wall. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 827-833, 2018.}, language = {en} } @article{TippkoetterWollnySucketal.2014, author = {Tippk{\"o}tter, Nils and Wollny, Steffen and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland}, title = {Recycling of spent oil bleaching earth as source of glycerol for the anaerobic production of acetone, butanol, and ethanol with Clostridium diolis and lipolytic Clostridium lundense}, series = {Engineering in Life Sciences}, volume = {14}, journal = {Engineering in Life Sciences}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1618-2863}, doi = {10.1002/elsc.201300113}, pages = {425 -- 432}, year = {2014}, abstract = {A major part of edible oil is subjected to bleaching procedures, primarily with minerals applied as adsorbers. Their recycling is currently done either by regaining the oil via organic solvent extraction or by using the spent bleaching earth (SBE) as additive for animal feed, etc. As a new method, the reutilization of the by-product SBE for the microbiologic formation of acetone, butanol, and ethanol (ABE) is presented as proof-of-concept. The SBE was taken from a palm oil cleaning process. The recycling concept is based on the application of lipolytic clostridia strains. Due to considerably long fermentation times, co-fermentation with Candida rugosa and enzymatic hydrolyses of the bound oil with a subsequent clostridia fermentation are shown as alternative routes. Anaerobic fermentations under comparison of different clostridia strains were performed with glycerol media, enzymatically hydrolyzed palm oil and SBE. Solutes, side product compositions and productivities were quantified via HPLC. A successful production of ABE solutes from SBE has been done with a yield of 0.15 g butanol per gram of bound glycerol. Thus, the biotechnological recycling of the waste stream is possible in principle. Inhibition of the substrate suspension has been observed. A chromatographic ion-exchange of substrates increased the biomass concentration.}, language = {en} } @article{ThielTippkoetterSucketal.2013, author = {Thiel, Alexander and Tippk{\"o}tter, Nils and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland}, title = {New zeolite adsorbents for downstream processing of polyphenols from renewable resources}, series = {Engineering in Life Sciences}, volume = {13}, journal = {Engineering in Life Sciences}, number = {3}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/elsc.201200188}, pages = {239 -- 246}, year = {2013}, abstract = {Commercial materials with polyvinylpolypyrrolidone and polymeric amberlites (XAD7HP, XAD16) are commonly used for the adsorptive downstream processing of polyphenols from renewable resources. In this study, beta-zeolite-based adsorbent systems were examined, and their properties were compared to organic resins. Batch adsorption experiments were conducted with synthetic solutions of major polyphenols. Adsorption isotherms and desorption characteristics of individual adsorbent were determined based on these results. Maximum adsorption capacities were calculated using the Langmuir model. For example, the zeolites had capacities up to 203.2 mg/g for ferulic acid. To extend these results to a complex system, additional experiments were performed on rapeseed meal and wheat seed extracts as representative renewable resources. HPLC analysis showed that with 7.5\% w/v, which is regarded as the optimum amount of zeolites, zeolites A and B could bind 100\% of the major polyphenols as well as release polyphenols at high yields. Additionally, regeneration experiments were performed with isopropyl alcohol at 99°C to evaluate how zeolites regenerate under mild conditions. The results showed only a negligible loss of adsorption capacity and no loss of desorption capacity. In summary, it was concluded that beta-zeolites were promising adsorbents for developing new processes to isolate polyphenols from renewable resources.}, language = {en} } @article{TippkoetterAlKaidyWollnyetal.2013, author = {Tippk{\"o}tter, Nils and Al-Kaidy, Huschyar and Wollny, Steffen and Ulber, Roland}, title = {Functionalized magnetizable particles for downstream processing in single-use systems}, series = {Chemie Ingenieur Technik}, volume = {85}, journal = {Chemie Ingenieur Technik}, number = {1-2: Special Issue: Single-Use Technology}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/cite.201200130}, pages = {76 -- 86}, year = {2013}, abstract = {Biotechnological downstream processing is usually an elaborate procedure, requiring a multitude of unit operations to isolate the target component. Besides the disadvantageous space-time yield, the risks of cross-contaminations and product loss grow fast with the complexity of the isolation procedure. A significant reduction of unit operations can be achieved by application of magnetic particles, especially if these are functionalized with affinity ligands. As magnetic susceptible materials are highly uncommon in biotechnological processes, target binding and selective separation of such particles from fermentation or reactions broths can be done in a single step. Since the magnetizable particles can be produced from iron salts and low priced polymers, a single-use implementation of these systems is highly conceivable. In this article, the principles of magnetizable particles, their synthesis and functionalization are explained. Furthermore, applications in the area of reaction engineering, microfluidics and downstream processing are discussed focusing on established single-use technologies and development potential.}, language = {en} } @article{SiekerNeunerDimitrovaetal.2011, author = {Sieker, Tim and Neuner, Andreas and Dimitrova, Darina and Tippk{\"o}tter, Nils and Muffler, Kai and Bart, Hans-J{\"o}rg and Heinzle, Elmar and Ulber, Roland}, title = {Ethanol production from grass silage by simultaneous pretreatment, saccharification and fermentation: First steps in the process development}, series = {Engineering in Life Sciences}, volume = {11}, journal = {Engineering in Life Sciences}, number = {4}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/elsc.201000160}, pages = {436 -- 442}, year = {2011}, abstract = {Grass silage provides a great potential as renewable feedstock. Two fractions of the grass silage, a press juice and the fiber fraction, were evaluated for their possible use for bioethanol production. Direct production of ethanol from press juice is not possible due to high concentrations of organic acids. For the fiber fraction, alkaline peroxide or enzymatic pretreatment was used, which removes the phenolic acids in the cell wall. In this study, we demonstrate the possibility to integrate the enzymatic pretreatment with a simultaneous saccharification and fermentation to achieve ethanol production from grass silage in a one-process step. Achieved yields were about 53 g ethanol per kg silage with the alkaline peroxide pretreatment and 91 g/kg with the enzymatic pretreatment at concentrations of 8.5 and 14.6 g/L, respectively. Furthermore, it was shown that additional supplementation of the fermentation medium with vitamins, trace elements and nutrient salts is not necessary when the press juice is directly used in the fermentation step.}, language = {en} } @article{AlKaidyDuweHusteretal.2015, author = {Al-Kaidy, Huschyar and Duwe, Anna and Huster, Manuel and Muffler, Kai and Schlegel, Christin and Tim, Sieker and Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Biotechnology and bioprocess engineering - from the first ullmann's article to recent trends}, series = {ChemBioEng Reviews}, volume = {2}, journal = {ChemBioEng Reviews}, number = {3}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/cben.201500008}, pages = {175 -- 184}, year = {2015}, abstract = {For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed.}, language = {en} } @article{ThielMufflerTippkoetteretal.2015, author = {Thiel, Alexander and Muffler, Kai and Tippk{\"o}tter, Nils and Suck, Kirstin and Sohling, Ulrich and Hruschka, Steffen M. and Ulber, Roland}, title = {A novel integrated downstream processing approach to recover sinapic acid, phytic acid and proteins from rapeseed meal}, series = {Journal of Chemical Technology and Biotechnology}, volume = {90}, journal = {Journal of Chemical Technology and Biotechnology}, number = {11}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/jctb.4664}, pages = {1999 -- 2006}, year = {2015}, abstract = {BACKGROUND Currently, several techniques exist for the downstream processing of protein, phytic acid and sinapic acid from rapeseed and rapeseed meal, but no technique has been developed to separate all of the components in one process. In this work, two new downstream processing strategies focusing on recovering sinapic acid, phytic acid and protein from rapeseed meal were established. RESULTS The sinapic acid content was enhanced by a factor of 4.5 with one method and 5.1 with the other. The isolation of sinapic acid was accomplished using a zeolite-based adsorbent with high adsorptive and optimal desorption characteristics. Phytic acid was isolated using the anion-exchange resin Purolite A200®. In addition, the processes resulted in two separated protein fractions. The ratios of globulin and albumin ratio to the total protein were 59.2\% and 40.1\%, respectively. The steps were then combined in two different ways: (a) a 'sequential process' using the zeolite and A200 in batch processes; and (b) a 'parallel process' using only A200 in a chromatographic system to separate all of the compounds. CONCLUSIONS It can be concluded that isolation of all three components was possible in both processes. These could enhance the added value of current processes using rapeseed meal as a protein source. © 2015 Society of Chemical Industry}, language = {en} } @article{SchumannRoginSchneideretal.2015, author = {Schumann, Christiane and Rogin, Sabine and Schneider, Horst and Tippk{\"o}tter, Nils and Oster, J{\"u}rgen and Kampeis, Percy}, title = {Simultane Atline-Quantifizierung von Magnetpartikeln und Mikroorganismen bei einer HGMS-Filtration}, series = {Chemie Ingenieur Technik}, volume = {87}, journal = {Chemie Ingenieur Technik}, number = {1-2}, doi = {10.1002/cite.201300158}, pages = {137 -- 149}, year = {2015}, abstract = {Es wird eine neue Atline-Messmethode vorgestellt, mit der w{\"a}hrend einer Hochgradienten-Magnetseparation (HGMS)-Filtration eine simultane Quantifizierung von Magnetpartikeln und Mikroorganismen im Filtrat vorgenommen werden kann. Dabei gelingt die Quantifizierung signifikant besser als mit bisher verwendeten Messmethoden. Mit dieser Methode ist es m{\"o}glich, die Trennleistung einer HGMS-Filtration zu bestimmen und einen Filterdurchbruch durch Konzentrationsanstiege im Bereich einiger µg L-1 von Magnetpartikeln im Filtrat fr{\"u}hzeitig zu detektieren, ohne dass nennenswerte Partikelmengen verloren gehen.}, language = {de} } @article{ThielMufflerTippkoetteretal.2015, author = {Thiel, Alexander and Muffler, Kai and Tippk{\"o}tter, Nils and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland}, title = {Aufarbeitung von Polyphenolen aus Weizen mittels Zeolithen am Beispiel der Ferulas{\"a}ure}, series = {Chemie IngenieurTechnik}, volume = {87}, journal = {Chemie IngenieurTechnik}, number = {1-2}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/cite.201400031}, pages = {128 -- 136}, year = {2015}, abstract = {Aufarbeitung von Polyphenolen aus Weizenmittels Zeolithen am Beispiel der Ferulasa¨ ureAlexander Thiel1, Kai Muffler1, Nils Tippko¨ tter1, Kirstin Suck2, Ulrich Sohling2, Friedrich Ruf3und Roland Ulber1,*DOI: 10.1002/cite.201400031Bei der Ferulasa¨ure handelt es sich um einen Wertstoff, der aus Weizen gewonnen und in der Lebensmittel- und Pharma-industrie eingesetzt werden kann. Der Einsatz von Weizen als nachwachsende Rohstoffquelle ist allerdings nur dann wirt-schaftlich durchfu¨hrbar, wenn eine Prozessintegration in die bestehenden industriellen Verfahren gewa¨hrleistet oder einedirekte Konkurrenz zur Mehl- und Sta¨rkeindustrie vermieden werden kann. In diesem Artikel wird ein Verfahren aufge-zeigt, welches hohe Ausbeuten ermo¨glicht und eine Konkurrenz zu bestehenden Verwertungspfaden vermeidet.}, language = {de} } @article{ElQuardiStreckertBitzetal.2011, author = {El Quardi, A. and Streckert, J. and Bitz, Andreas and M{\"u}nkner, S. and Engel, J. and Hansen, V.}, title = {New fin-line devices for radiofrequency exposure of small biological samples in vitro allowing whole-cell patch clamp recordings}, series = {Bioelectromagnetics}, volume = {32}, journal = {Bioelectromagnetics}, number = {2}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-186X}, doi = {10.1002/bem.20621}, pages = {102 -- 112}, year = {2011}, abstract = {The development and analysis of three waveguides for the exposure of small biological in vitro samples to mobile communication signals at 900 MHz (GSM, Global System for Mobile Communications), 1.8 GHz (GSM), and 2 GHz (UMTS, Universal Mobile Telecommunications System) is presented. The waveguides were based on a fin-line concept and the chamber containing the samples bathed in extracellular solution was placed onto two fins with a slot in between, where the exposure field concentrates. Measures were taken to allow for patch clamp recordings during radiofrequency (RF) exposure. The necessary power for the achievement of the maximum desired specific absorption rate (SAR) of 20 W/kg (average over the mass of the solution) was approximately Pin = 50 mW, Pin = 19 mW, and Pin = 18 mW for the 900 MHz, 1800 MHz, and 2 GHz devices, respectively. At 20 W/kg, a slight RF-induced temperature elevation in the solution of no more than 0.3 °C was detected, while no thermal offsets due to the electromagnetic exposure could be detected at the lower SAR settings (2, 0.2, and 0.02 W/kg). A deviation of 10\% from the intended solution volume yielded a calculated SAR deviation of 8\% from the desired value. A maximum ±10\% variation in the local SAR could occur when the position of the patch clamp electrode was altered within the area where the cells to be investigated were located.}, language = {en} } @article{MolinnusPoghossianKeusgenetal.2017, author = {Molinnus, Denise and Poghossian, Arshak and Keusgen, Michael and Katz, Evgeny and Sch{\"o}ning, Michael Josef}, title = {Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips}, series = {Electroanalysis}, volume = {29}, journal = {Electroanalysis}, number = {8}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201700208}, pages = {1840 -- 1849}, year = {2017}, abstract = {The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor.}, language = {en} } @article{GrafSteinhofLotzetal.2009, author = {Graf, Alain-Michel and Steinhof, Rafael and Lotz, Martin and Tippk{\"o}tter, Nils and Kasper, Cornelia and Beutel, Sascha and Ulber, Roland}, title = {Downstream-Processing mit Membranadsorbern zur Isolierung nativer Proteinfraktionen aus Kartoffelfruchtwasser}, series = {Chemie Ingenieur Technik}, volume = {81}, journal = {Chemie Ingenieur Technik}, number = {3}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/cite.200800139}, pages = {267 -- 274}, year = {2009}, abstract = {Bei der St{\"a}rkeproduktion entstehendes Kartoffelfruchtwasser besitzt mit 2 - 3 \% einen hohen Anteil an ern{\"a}hrungsphysiologisch interessanten Proteinen. Die industrielle Gewinnung dieser Proteinfracht liefert jedoch lediglich ein minderwertiges, denaturiertes Produkt. Mit Hilfe der Membranadsorber-Technologie lassen sich aus Kartoffelfruchtwasser unter milden Reaktionsbedingungen native bioaktive Proteinfraktionen gewinnen. Geeignete Trennbedingungen wurden im Labormaßstab entwickelt und in den Technikumsmaßstab {\"u}bertragen. An Anionenaustauscher-Membranadsorbern mit einer Membranfl{\"a}che von 10 000 cm2 wurde eine Patatinhaltige Fraktion (44 kDa) mit Bindungskapazit{\"a}ten von 0,37 mg/cm2 isoliert. Eine niedermolekulare Proteinfraktion mit Protease-Inhibitoren konnte durch Kationenaustauscher-Membranadsorber mit Bindungskapazit{\"a}ten von 1,00 mg/cm2 gewonnen werden. Sie ist f{\"u}r verschiedenste Applikationen in der pharmazeutischen, kosmetischen und der Nahrungsmittelindustrie interessant z. B. f{\"u}r Appetitz{\"u}gler oder muskelaufbauende Proteinpr{\"a}parate. Der Aufreinigung der nativen Proteinfraktionen durch Ultra-/Diafiltration schließt sich die Konfektionierung durch Spr{\"u}htrocknung an. Die bioanalytische Charakterisierung der Produkte belegt die Reinheit und die enzymatische Aktivit{\"a}t sowie die Abreicherung von St{\"o}rkomponenten wie Glykoalkaloide und Polyphenoloxidasen.}, language = {de} } @article{TippkoetterWollnyKampeisetal.2011, author = {Tippk{\"o}tter, Nils and Wollny, S. and Kampeis, P. and Oster, J. and Schneider, H. and Ulber, R.}, title = {Magnetseparation von Proteinen : Separation von Zielmolek{\"u}len durch hochselektive Aptamere}, series = {GIT Labor-Fachzeitschrift}, volume = {55}, journal = {GIT Labor-Fachzeitschrift}, number = {10}, publisher = {Wiley}, address = {Weinheim}, pages = {666}, year = {2011}, abstract = {Durch die Kombination von Oligonukleotid-Liganden (Aptameren) hoher Bindungsaffinit{\"a}ten mit hochselektiv abtrennbaren magnetisierbaren Mikropartikeln wird eine einstufige Separation von Zielmolek{\"u}len aus mikrobiologischen Produktionsans{\"a}tzen m{\"o}glich. Die Aptamere werden hierf{\"u}r reversibel auf den Partikeloberfl{\"a}chen gebunden und f{\"u}r die spezifische Isolierung von Bioprodukten eingesetzt. Die Abtrennung der beladenen Partikel erfolgt durch einen neuen Rotor-Stator-Separator mit Hochgradient-Magnetfeld.}, language = {de} } @article{RietschPfaffenrotBitzetal.2017, author = {Rietsch, Stefan H. G. and Pfaffenrot, Viktor and Bitz, Andreas and Orzada, Stephan and Brunheim, Sascha and Lazik-Palm, Andrea and Theysohn, Jens M. and Ladd, Mark E. and Quick, Harald H. and Kraff, Oliver}, title = {An 8-channel transceiver 7-channel receive RF coil setup for high SNR ultrahigh-field MRI of the shoulder at 7T}, series = {Medical Physics}, journal = {Medical Physics}, number = {Article in press}, publisher = {Wiley}, address = {Hoboken}, issn = {0094-2405}, doi = {10.1002/mp.12612}, year = {2017}, language = {en} } @article{LaumannMainzKrahwinkel2017, author = {Laumann, J{\"o}rg and Mainz, Stefan and Krahwinkel, Manuel}, title = {Traglastuntersuchungen an Koppelpfetten bei Biegung um die schwache Achse und Torsion}, series = {Stahlbau}, volume = {86}, journal = {Stahlbau}, number = {11}, publisher = {Wiley}, address = {Weinheim}, issn = {0038-9145}, doi = {10.1002/stab.201710544}, pages = {1005 -- 1016}, year = {2017}, language = {de} } @inproceedings{FateriGebhardtRenftle2015, author = {Fateri, Miranda and Gebhardt, Andreas and Renftle, Georg}, title = {Additive manufacturing of drainage segments for cooling system of crucible melting furnaces}, series = {Advanced Processing and Manufacturing Technologies for Structural and Multifunctional Materials II, International Symposium on Advanced Processing and Manufacturing Technologies for Structural and Multifunctional Materials, ICACC 15, 39th International Conference on Advanced Ceramics and Composites, Daytona Beach, FL, US, Jan 25-30, 2015}, booktitle = {Advanced Processing and Manufacturing Technologies for Structural and Multifunctional Materials II, International Symposium on Advanced Processing and Manufacturing Technologies for Structural and Multifunctional Materials, ICACC 15, 39th International Conference on Advanced Ceramics and Composites, Daytona Beach, FL, US, Jan 25-30, 2015}, publisher = {Wiley}, address = {Hoboken}, issn = {0196-6219}, doi = {10.1002/9781119211662.ch14}, pages = {123 -- 131}, year = {2015}, language = {en} } @article{JungStaat2019, author = {Jung, Alexander and Staat, Manfred}, title = {Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue}, series = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik}, volume = {42}, journal = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik}, number = {4}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2608}, doi = {10.1002/gamm.201900002}, pages = {11 Seiten}, year = {2019}, language = {en} } @article{LyonsMikuckiGermanetal.2019, author = {Lyons, W. Berry and Mikucki, Jill A. and German, Laura A. and Welch, Kathleen A. and Welch, Susan A. and Gardener, Christopher B. and Tulaczyk, Slawek M. and Pettit, Erin C. and Kowalski, Julia and Dachwald, Bernd}, title = {The Geochemistry of Englacial Brine from Taylor Glacier, Antarctica}, series = {Journal of Geophysical Research: Biogeosciences}, journal = {Journal of Geophysical Research: Biogeosciences}, publisher = {Wiley}, address = {Hoboken}, issn = {2169-8961}, doi = {10.1029/2018JG004411}, year = {2019}, language = {en} } @article{CampenKowalskiLyonsetal.2019, author = {Campen, R. and Kowalski, Julia and Lyons, W.B. and Tulaczyk, S. and Dachwald, Bernd and Pettit, E. and Welch, K. A. and Mikucki, J.A.}, title = {Microbial diversity of an Antarctic subglacial community and high-resolution replicate sampling inform hydrological connectivity in a polar desert}, series = {Environmental Microbiology}, journal = {Environmental Microbiology}, number = {accepted article}, publisher = {Wiley}, address = {Weinheim}, issn = {1462-2920}, doi = {10.1111/1462-2920.14607}, year = {2019}, language = {en} } @article{MoraisSilvaDantasetal.2019, author = {Morais, Paulo V. and Silva, Anielle C. A. and Dantas, Noelio O. and Sch{\"o}ning, Michael Josef and Siqueira, Jos{\´e} R., Jr.}, title = {Hybrid Layer-by-Layer Film of Polyelectrolytes-Embedded Catalytic CoFe2O4 Nanocrystals as Sensing Units in Capacitive Electrolyte-Insulator-Semiconductor Devices}, series = {physica status solidi a : applications and materials sciences}, volume = {216}, journal = {physica status solidi a : applications and materials sciences}, number = {1900044}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/pssa.201900044}, pages = {1 -- 9}, year = {2019}, language = {en} } @article{RietschBrunheimOrzadaetal.2019, author = {Rietsch, Stefan H. G. and Brunheim, Sascha and Orzada, Stephan and Voelker, Maximilian N. and Maderwald, Stefan and Bitz, Andreas and Gratz, Marcel and Ladd, Mark E. and Quick, Harald H.}, title = {Development and evaluation of a 16-channel receive-only RF coil to improve 7T ultra-high field body MRI with focus on the spine}, series = {Magnetic Resonance in Medicine}, journal = {Magnetic Resonance in Medicine}, number = {Early view}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2594}, doi = {10.1002/mrm.27731}, year = {2019}, language = {en} } @article{SchiffelsSelmer2019, author = {Schiffels, Johannes and Selmer, Thorsten}, title = {Combinatorial assembly of ferredoxin-linked modules in Escherichia coli yields a testing platform for Rnf-complexes}, series = {Biotechnology and Bioengineering}, journal = {Biotechnology and Bioengineering}, number = {accepted article}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/bit.27079}, pages = {1 -- 36}, year = {2019}, language = {en} } @article{GerhardsSanderZivkovicetal.2020, author = {Gerhards, Michael and Sander, Volker and Zivkovic, Miroslav and Belloum, Adam and Bubak, Marian}, title = {New approach to allocation planning of many-task workflows on clouds}, series = {Concurrency and Computation: Practice and Experience}, volume = {32}, journal = {Concurrency and Computation: Practice and Experience}, number = {2 Article e5404}, publisher = {Wiley}, address = {Chichester}, issn = {1532-0634}, doi = {10.1002/cpe.5404}, pages = {1 -- 16}, year = {2020}, abstract = {Experience has shown that a priori created static resource allocation plans are vulnerable to runtime deviations and hence often become uneconomic or highly exceed a predefined soft deadline. The assumption of constant task execution times during allocation planning is even more unlikely in a cloud environment where virtualized resources vary in performance. Revising the initially created resource allocation plan at runtime allows the scheduler to react on deviations between planning and execution. Such an adaptive rescheduling of a many-task application workflow is only feasible, when the planning time can be handled efficiently at runtime. In this paper, we present the static low-complexity resource allocation planning algorithm (LCP) applicable to efficiently schedule many-task scientific application workflows on cloud resources of different capabilities. The benefits of the presented algorithm are benchmarked against alternative approaches. The benchmark results show that LCP is not only able to compete against higher complexity algorithms in terms of planned costs and planned makespan but also outperforms them significantly by magnitudes of 2 to 160 in terms of required planning time. Hence, LCP is superior in terms of practical usability where low planning time is essential such as in our targeted online rescheduling scenario.}, language = {en} } @article{DigelWehlitzKayseretal.2018, author = {Digel, Ilya and Wehlitz, V. and Kayser, Peter and Figiel-Lange, A. and Bassam, R. and Rundstedt, F. von}, title = {Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids}, series = {Plant Pathology}, volume = {67}, journal = {Plant Pathology}, number = {2}, publisher = {Wiley}, address = {Oxford}, issn = {1365-3059}, doi = {10.1111/ppa.12750}, pages = {358 -- 365}, year = {2018}, abstract = {Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel 'suspension depletion' approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10-12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach.}, language = {en} } @article{EngelGemuendeHoltmannetal.2019, author = {Engel, Mareike and Gem{\"u}nde, Andre and Holtmann, Dirk and M{\"u}ller-Renno, Christine and Ziegler, Christiane and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Clostridium acetobutylicum's connecting world: cell appendage formation in bioelectrochemical systems}, series = {ChemElectroChem}, journal = {ChemElectroChem}, number = {Accepted Article}, publisher = {Wiley}, address = {Weinheim}, issn = {2196-0216}, doi = {10.1002/celc.201901656}, year = {2019}, language = {en} } @article{NoureddineKraffLaddetal.2019, author = {Noureddine, Yacine and Kraff, Oliver and Ladd, Mark E. and Wrede, Karsten and Chen, Bixia and Quick, Harald H. and Schaefers, Georg and Bitz, Andreas}, title = {Radiofrequency induced heating around aneurysm clips using a generic birdcage head coil at 7 Tesla under consideration of the minimum distance to decouple multiple aneurysm clips}, series = {Magnetic Resonance in Medicine}, journal = {Magnetic Resonance in Medicine}, number = {Early view}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2594}, doi = {10.1002/mrm.27835}, pages = {1 -- 17}, year = {2019}, language = {en} } @article{DrummEmhardtKoketal.2020, author = {Drumm, Christian and Emhardt, Selina N. and Kok, Ellen M. and Jarodzka, Halzka and Brand-Gruwel, Saskia and van Gog, Tamara}, title = {How Experts Adapt Their Gaze Behavior When Modeling a Task to Novices}, series = {Cognitive science}, volume = {44}, journal = {Cognitive science}, number = {9}, publisher = {Wiley}, address = {Weinheim}, issn = {1551-6709}, doi = {10.1111/cogs.12893}, pages = {26}, year = {2020}, abstract = {Domain experts regularly teach novice students how to perform a task. This often requires them to adjust their behavior to the less knowledgeable audience and, hence, to behave in a more didactic manner. Eye movement modeling examples (EMMEs) are a contemporary educational tool for displaying experts' (natural or didactic) problem-solving behavior as well as their eye movements to learners. While research on expert-novice communication mainly focused on experts' changes in explicit, verbal communication behavior, it is as yet unclear whether and how exactly experts adjust their nonverbal behavior. This study first investigated whether and how experts change their eye movements and mouse clicks (that are displayed in EMMEs) when they perform a task naturally versus teach a task didactically. Programming experts and novices initially debugged short computer codes in a natural manner. We first characterized experts' natural problem-solving behavior by contrasting it with that of novices. Then, we explored the changes in experts' behavior when being subsequently instructed to model their task solution didactically. Experts became more similar to novices on measures associated with experts' automatized processes (i.e., shorter fixation durations, fewer transitions between code and output per click on the run button when behaving didactically). This adaptation might make it easier for novices to follow or imitate the expert behavior. In contrast, experts became less similar to novices for measures associated with more strategic behavior (i.e., code reading linearity, clicks on run button) when behaving didactically.}, language = {en} } @article{HentschkeHagerHojdis2014, author = {Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils}, title = {Molecular Modeling Approach to the Prediction of Mechanical Properties of Silica-Reinforced Rubbers}, series = {Journal of Applied Polymer Science}, volume = {131}, journal = {Journal of Applied Polymer Science}, number = {18}, publisher = {Wiley}, address = {New York, NY}, issn = {1097-4628}, doi = {10.1002/app.40806}, pages = {1 -- 9}, year = {2014}, abstract = {Recently, we have suggested a nanomechanical model for dissipative loss in filled elastomer networks in the context of the Payne effect. The mechanism is based on a total interfiller particle force exhibiting an intermittent loop, due to the combination of short-range repulsion and dispersion forces with a long-range elastic attraction. The sum of these forces leads, under external strain, to a spontaneous instability of "bonds" between the aggregates in a filler network and attendant energy dissipation. Here, we use molecular dynamics simulations to obtain chemically realistic forces between surface modified silica particles. The latter are combined with the above model to estimate the loss modulus and the low strain storage modulus in elastomers containing the aforementioned filler-compatibilizer systems. The model is compared to experimental dynamic moduli of silica filled rubbers. We find good agreement between the model predictions and the experiments as function of the compatibilizer's molecular structure and its bulk concentration.}, language = {en} } @article{AlexyukBogoyavlenskiyAlexyuketal.2021, author = {Alexyuk, Madina and Bogoyavlenskiy, Andrey and Alexyuk, Pavel and Moldakhanov, Yergali and Berezin, Vladimir and Digel, Ilya}, title = {Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity}, series = {MicrobiologyOpen}, volume = {10}, journal = {MicrobiologyOpen}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {2045-8827}, doi = {10.1002/mbo3.1142}, pages = {1 -- 10}, year = {2021}, abstract = {Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40\% and 37\% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.}, language = {en} } @article{ReisertSchneiderGeissleretal.2013, author = {Reisert, Steffen and Schneider, Benno and Geissler, Hanno and Gompel, Matthias van and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Multi-sensor chip for the investigation of different types of metal oxides for the detection of H2O2 in the ppm range}, series = {physica status solidi (a)}, volume = {210}, journal = {physica status solidi (a)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, pages = {898 -- 904}, year = {2013}, abstract = {In this work, a multi-sensor chip for the investigation of the sensing properties of different types of metal oxides towards hydrogen peroxide in the ppm range is presented. The fabrication process and physical characterization of the multi-sensor chip are described. Pure SnO2 and WO3 as well as Pd- and Pt-doped SnO2 films are characterized in terms of their sensitivity to H2O2. The sensing films have been prepared by drop-coating of water-dispensed nano-powders. A physical characterization, including scanning electron microscopy and X-ray diffraction analysis of the deposited metal-oxide films, was done. From the measurements in hydrogen peroxide atmosphere, it could be shown, that all of the tested metal oxide films are suitable for the detection of H2O2 in the ppm range. The highest sensitivity and reproducibility was achieved using Pt-doped SnO2. Calibration plot of a SnO2, WO3, Pt-, and Pd-doped SnO2 gas sensor for H2O2 concentrations in the ppm range.}, language = {en} } @article{FaganBitzBjoerkmanBurtscheretal.2021, author = {Fagan, Andrew J. and Bitz, Andreas and Bj{\"o}rkman-Burtscher, Isabella M. and Collins, Christopher M. and Kimbrell, Vera and Raaijmakers, Alexander J. E.}, title = {7T MR Safety}, series = {Journal of Magnetic Resonance Imaging (JMRI)}, volume = {53}, journal = {Journal of Magnetic Resonance Imaging (JMRI)}, number = {2}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2586}, doi = {10.1002/jmri.27319}, pages = {333 -- 346}, year = {2021}, language = {en} } @article{ButenwegRosin2020, author = {Butenweg, Christoph and Rosin, Julia}, title = {Seismischer Nachweis von Mauerwerksbauten in deutschen Erdbebengebieten}, series = {Mauerwerk}, volume = {24}, journal = {Mauerwerk}, number = {2}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1022}, doi = {10.1002/dama.202000006}, pages = {108 -- 113}, year = {2020}, abstract = {Mit finanzieller Unterst{\"u}tzung der Deutschen Gesellschaft f{\"u}r Mauerwerks- und Wohnungsbau e.V. (DGfM) und des Deutschen Instituts f{\"u}r Bautechnik in Berlin (DIBt) wurden zwei aufeinander aufbauende Forschungsvorhaben zur Verbesserung der seismischen Nachweise von Mauerwerksbauten in deutschen Erdbebengebieten durchgef{\"u}hrt. Zun{\"a}chst wurde das seismische Verhalten von drei modernen unbewehrten Mauerwerksgeb{\"a}uden in der Region Emilia Romagna in Italien w{\"a}hrend der Erdbebenserie im Jahr 2012 in Kooperation mit der Universit{\"a}t Pavia eingehend untersucht. Aufbauend auf den Erkenntnissen dieser Untersuchungen wurde ein verbessertes seismisches Bemessungskonzept f{\"u}r unbewehrte Mauerwerksbauten erarbeitet. Der Beitrag stellt die wesentlichen Ergebnisse dieser Forschungsarbeiten und deren Eingang in die Normung vor.}, language = {de} } @article{MarinkovicButenweg2020, author = {Marinkovic, Marko and Butenweg, Christoph}, title = {Ausfachungen aus Ziegelmauerwerk in Stahlbetonrahmentragwerken unter Erdbebenbeanspruchung}, series = {Mauerwerk}, volume = {24}, journal = {Mauerwerk}, number = {4}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1022}, doi = {10.1002/dama.202000011}, pages = {194 -- 205}, year = {2020}, abstract = {Stahlbetonrahmentragwerke mit Ausfachungen aus Mauerwerk weisen nach Erdbeben h{\"a}ufig schwere Sch{\"a}den auf. Gr{\"u}nde hierf{\"u}r sind die Beanspruchungen der Ausfachungsw{\"a}nde durch die aufgezwungenen Rahmenverformungen in Wandebene und die gleichzeitig auftretenden Tr{\"a}gheitskr{\"a}fte senkrecht zur Wandebene in Kombination mit der konstruktiven Ausf{\"u}hrung des Ausfachungsmauerwerks. Die Ausfachung wird in der Regel knirsch gegen die Rahmenst{\"u}tzen gemauert, wobei der Verschluss der oberen Fuge mit M{\"o}rtel oder Montageschaum erfolgt. Dadurch kommt es im Erdbebenfall zu lokalen Interaktionen zwischen Ausfachung und Rahmen, die in der Folge zu einem Versagen einzelner Ausfachungsw{\"a}nde oder zu einem sukzessiven Versagen des Gesamtgeb{\"a}udes f{\"u}hren k{\"o}nnen. Die beobachteten Sch{\"a}den waren die Motivation daf{\"u}r, in dem europ{\"a}ischen Forschungsprojekt INSYSME f{\"u}r Stahlbetonrahmentragwerke mit Ausfachungen aus hochw{\"a}rmed{\"a}mmenden Ziegelmauerwerk innovative L{\"o}sungen zur Verbesserung des seismischen Verhaltens zu entwickeln. Der vorliegende Beitrag stellt die im Rahmen des Projekts von den deutschen Projektpartnern (Universit{\"a}t Kassel, SDA-engineering GmbH) entwickelten L{\"o}sungen vor und vergleicht deren seismisches Verhalten mit der traditionellen Ausf{\"u}hrung der Ausfachungsw{\"a}nde. Grundlage f{\"u}r den Vergleich sind statisch-zyklische Wandversuche und Simulationen auf Wandebene. Aus den Ergebnissen werden Empfehlungen f{\"u}r die erdbebensichere Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk abgeleitet.}, language = {de} } @article{BrockhausBehbahaniMurisetal.2021, author = {Brockhaus, Moritz K. and Behbahani, Mehdi and Muris, Farina and Jansen, Sebastian V. and Schmitz- Rode, Thomas and Steinseifer, Ulrich and Clauser, Johanna C.}, title = {In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept}, series = {Artificial Organs}, volume = {45}, journal = {Artificial Organs}, number = {12}, publisher = {Wiley}, address = {Weinheim}, issn = {1525-1594}, doi = {10.1111/aor.14046}, pages = {1513 -- 1521}, year = {2021}, abstract = {Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6\% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.}, language = {en} } @article{BlankeRegerDoeringetal.2021, author = {Blanke, Tobias and Reger, Vitali and D{\"o}ring, Bernd and G{\"o}ttsche, Joachim and Kuhnhenne, Markus}, title = {Koaxiale Stahlenergiepf{\"a}hle}, series = {Stahlbau}, volume = {90. 2021}, journal = {Stahlbau}, number = {6}, publisher = {Wiley}, address = {Weinheim}, pages = {417 -- 424}, year = {2021}, abstract = {Ein entscheidender Teil der Energiewende ist die W{\"a}rmewende im Geb{\"a}udesektor. Ein Schl{\"u}sselelement sind hier W{\"a}rmepumpen. Diese ben{\"o}tigen eine W{\"a}rmequelle, der sie Energie entziehen k{\"o}nnen, um sie auf ein h{\"o}heres Temperaturniveau zu transformieren. Diese W{\"a}rmequelle kann bspw. das Erdreich sein, dessen W{\"a}rme durch Erdsonden erschlossen werden kann. In diesem Beitrag werden in Stahlpf{\"a}hle integrierte Koaxialsonden mit dem Stand der Technik von Erdsonden gleichen Durchmessers bez{\"u}glich ihrer thermischen Leistungsmerkmale verglichen. Die Stahlenergiepf{\"a}hle bieten neben der W{\"a}rmegewinnung weitere Vorteile, da sie auch eine statische Funktion {\"u}bernehmen und r{\"u}ckstandsfrei zur{\"u}ckgebaut werden k{\"o}nnen. Es werden analytische und numerische Berechnungen vorgestellt, um die thermischen Potenziale beider Systeme zu vergleichen. Außerdem wird ein Testaufbau gezeigt, bei dem Stahlenergiepf{\"a}hle in zwei verschiedenen L{\"a}ngen mit vorhandenen g{\"a}ngigen Erdsonden verglichen werden k{\"o}nnen. Die Berechnungen zeigen einen deutlichen thermischen Mehrertrag zwischen 26 \% und 148 \% der Stahlenergiepf{\"a}hle gegen{\"u}ber dem Stand der Technik abh{\"a}ngig vom Erdreich. Die Messergebnisse zeigen einen thermischen Mehrertrag von {\"u}ber 100 \%. Es l{\"a}sst sich also signifikante Erdsondenl{\"a}nge einsparen. Dabei ist zu beachten, dass sich damit der thermisch genutzte Bereich des Erdreichs reduziert, wodurch die thermische Regeneration und/oder das Langzeitverhalten des Erdreichs an Bedeutung gewinnt.}, language = {de} } @article{PoettgenEdererAltherretal.2015, author = {P{\"o}ttgen, Philipp and Ederer, Thorsten and Altherr, Lena and Lorenz, Ulf and Pelz, Peter F.}, title = {Examination and optimization of a heating circuit for energy-efficient buildings}, series = {Energy Technology}, volume = {4}, journal = {Energy Technology}, number = {1}, publisher = {WILEY-VCH Verlag}, address = {Weinheim}, isbn = {2194-4296}, doi = {10.1002/ente.201500252}, pages = {136 -- 144}, year = {2015}, abstract = {The conference center darmstadtium in Darmstadt is a prominent example of energy efficient buildings. Its heating system consists of different source and consumer circuits connected by a Zortstr{\"o}m reservoir. Our goal was to reduce the energy costs of the system as much as possible. Therefore, we analyzed its supply circuits. The first step towards optimization is a complete examination of the system: 1) Compilation of an object list for the system, 2) collection of the characteristic curves of the components, and 3) measurement of the load profiles of the heat and volume-flow demand. Instead of modifying the system manually and testing the solution by simulation, the second step was the creation of a global optimization program. The objective was to minimize the total energy costs for one year. We compare two different topologies and show opportunities for significant savings.}, language = {en} } @article{ColomboDriraFrotscheretal.2022, author = {Colombo, Daniele and Drira, Slah and Frotscher, Ralf and Staat, Manfred}, title = {An element-based formulation for ES-FEM and FS-FEM models for implementation in standard solid mechanics finite element codes for 2D and 3D static analysis}, series = {International Journal for Numerical Methods in Engineering}, volume = {124}, journal = {International Journal for Numerical Methods in Engineering}, number = {2}, publisher = {Wiley}, address = {Chichester}, issn = {1097-0207}, doi = {10.1002/nme.7126}, pages = {402 -- 433}, year = {2022}, abstract = {Edge-based and face-based smoothed finite element methods (ES-FEM and FS-FEM, respectively) are modified versions of the finite element method allowing to achieve more accurate results and to reduce sensitivity to mesh distortion, at least for linear elements. These properties make the two methods very attractive. However, their implementation in a standard finite element code is nontrivial because it requires heavy and extensive modifications to the code architecture. In this article, we present an element-based formulation of ES-FEM and FS-FEM methods allowing to implement the two methods in a standard finite element code with no modifications to its architecture. Moreover, the element-based formulation permits to easily manage any type of element, especially in 3D models where, to the best of the authors' knowledge, only tetrahedral elements are used in FS-FEM applications found in the literature. Shape functions for non-simplex 3D elements are proposed in order to apply FS-FEM to any standard finite element.}, language = {en} } @article{KirchnerOberlaenderSusoetal.2013, author = {Kirchner, Patrick and Oberl{\"a}nder, Jan and Suso, Henri-Pierre and Rysstad, Gunnar and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards a wireless sensor system for real-time H2O2 monitoring in aseptic food processes}, series = {Physica status solidi (a)}, volume = {210}, journal = {Physica status solidi (a)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201200920}, pages = {877 -- 883}, year = {2013}, abstract = {A wireless sensor system based on the industrial ZigBee standard for low-rate wireless networking was developed that enables real-time monitoring of gaseous H2O2 during the package sterilization in aseptic food processes. The sensor system consists of a remote unit connected to a calorimetric gas sensor, which was already established in former works, and an external base unit connected to a laptop computer. The remote unit was built up by an XBee radio frequency (RF) module for data communication and a programmable system-on-chip controller to read out the sensor signal and process the sensor data, whereas the base unit is a second XBee RF module. For the rapid H2O2 detection on various locations inside the package that has to be sterilized, a novel read-out strategy of the calorimetric gas sensor was established, wherein the sensor response is measured within the short sterilization time and correlated with the present H2O2 concentration. In an exemplary measurement application in an aseptic filling machinery, the suitability of the new, wireless sensor system was demonstrated, wherein the influence of the gas velocity on the H2O2 distribution inside a package was determined and verified with microbiological tests.}, language = {en} } @article{HennemannKohlReisertetal.2013, author = {Hennemann, J{\"o}rg and Kohl, Claus-Dieter and Reisert, Steffen and Kirchner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Copper oxide nanofibres for detection of hydrogen peroxide vapour at high concentrations}, series = {physica status solidi (a)}, volume = {210}, journal = {physica status solidi (a)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201200775}, pages = {859 -- 863}, year = {2013}, abstract = {We present a sensor concept based on copper(II)oxide (CuO) nanofibres for the detection of hydrogen peroxide (H2O2) vapour in the percent per volume (\% v/v) range. The fibres were produced by using the electrospinning technique. To avoid water condensation in the pores, the fibres were initially modified by an exposure to H2S to get an enclosed surface. By a thermal treatment at 350 °C the fibres were oxidised back to CuO. Thereby, the visible pores disappear which was verified by SEM analysis. The fibres show a decrease of resistance with increasing H2O2 concentration which is due to the fact that hydrogen peroxide is an oxidising gas and CuO a p-type semiconductor. The sensor shows a change of resistance within the minute range to the exposure until the maximum concentration of 6.9\% v/v H2O2. At operating temperatures below 450 °C the corresponding sensor response to a concentration of 4.1\% v/v increases. The sensor shows a good reproducibility of the signal at different measurements. CuO seems to be a suitable candidate for the detection of H2O2 vapour at high concentrations. Resistance behaviour of the sensor under exposure to H2O2 vapours between 2.3 and 6.9\% v/v at an operating temperature of 450 °C.}, language = {en} } @article{SchusserLeinhosBaeckeretal.2013, author = {Schusser, Sebastian and Leinhos, Marcel and B{\"a}cker, Matthias and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers}, series = {Physica Status Solidi (A)}, volume = {210}, journal = {Physica Status Solidi (A)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-396X ; 0031-8965}, doi = {10.1002/pssa.201200941}, pages = {905 -- 910}, year = {2013}, abstract = {Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution.}, language = {en} } @article{IkenBronderGoretzkietal.2019, author = {Iken, Heiko and Bronder, Thomas and Goretzki, Alexander and Kriesel, Jana and Ahlborn, Kristina and Gerlach, Frank and Vonau, Winfried and Zander, Willi and Schubert, J{\"u}rgen and Sch{\"o}ning, Michael Josef}, title = {Development of a Combined pH- and Redox-Sensitive Bi-Electrode Glass Thin-Film Sensor}, series = {physica status solidi a : applications and materials sciences}, volume = {216}, journal = {physica status solidi a : applications and materials sciences}, number = {12}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201900114}, pages = {1 -- 8}, year = {2019}, language = {en} } @article{OezsoyluKizildagSchoeningetal.2019, author = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Effect of plasma treatment on the sensor properties of a light-addressable potentiometric sensor (LAPS)}, series = {physica status solidi a : applications and materials sciences}, volume = {216}, journal = {physica status solidi a : applications and materials sciences}, number = {20}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201900259}, pages = {8 Seiten}, year = {2019}, abstract = {A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment.}, language = {en} } @article{StreeseKotliarDeiserothetal.2020, author = {Streese, Lukas and Kotliar, Konstantin and Deiseroth, Arne and Infanger, Denis and Gugleta, Konstantin and Schmaderer, Christoph and Hanssen, Henner}, title = {Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial}, series = {Scandinavian Journal of Medicine and Science in Sports}, volume = {30}, journal = {Scandinavian Journal of Medicine and Science in Sports}, number = {2}, publisher = {Wiley}, address = {Oxford}, issn = {1600-0838}, doi = {10.1111/sms.13560}, pages = {272 -- 280}, year = {2020}, abstract = {The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1\%, post: 3.0 ± 2.2\%, P = .018) and AFarea (pre: 32.6 ± 28.4\%*s, post: 37.7 ± 30.6\%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8\%, post: 2.9 ± 1.8\%, P = .254; AFarea, pre: 41.6 ± 28.5\%*s, post: 37.8 ± 27.0\%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.}, language = {en} } @article{NguyenXuanRabczukNguyenThoietal.2011, author = {Nguyen-Xuan, H. and Rabczuk, T. and Nguyen-Thoi, T. and Tran, Thanh Ngoc and Nguyen-Thanh, N.}, title = {Computation of limit and shakedown loads using a node-based smoothed finite element method}, series = {International Journal for Numerical Methods in Engineering}, volume = {90}, journal = {International Journal for Numerical Methods in Engineering}, number = {3}, publisher = {Wiley}, address = {Weinheim}, issn = {1097-0207}, doi = {10.1002/nme.3317}, pages = {287 -- 310}, year = {2011}, abstract = {This paper presents a novel numerical procedure for computing limit and shakedown loads of structures using a node-based smoothed FEM in combination with a primal-dual algorithm. An associated primal-dual form based on the von Mises yield criterion is adopted. The primal-dual algorithm together with a Newton-like iteration are then used to solve this associated primal-dual form to determine simultaneously both approximate upper and quasi-lower bounds of the plastic collapse limit and the shakedown limit. The present formulation uses only linear approximations and its implementation into finite element programs is quite simple. Several numerical examples are given to show the reliability, accuracy, and generality of the present formulation compared with other available methods.}, language = {en} } @article{HugenrothNeidlinEngelmannetal.2021, author = {Hugenroth, Kristin and Neidlin, Michael and Engelmann, Ulrich M. and Kaufmann, Tim A. S. and Steinseifer, Ulrich and Heilmann, Torsten}, title = {Tipless Transseptal Cannula Concept Combines Improved Hemodynamic Properties and Risk-Reduced Placement: an In Silico Proof-of-Concept}, series = {Artificial Organs}, journal = {Artificial Organs}, number = {Accepted Article}, publisher = {Wiley}, address = {Weinheim}, issn = {1525-1594}, doi = {10.1111/aor.13964}, year = {2021}, language = {en} } @article{ErpicumCrookstonBombardellietal.2021, author = {Erpicum, Sebastien and Crookston, Brian M. and Bombardelli, Fabian and Bung, Daniel B. and Felder, Stefan and Mulligan, Sean and Oertel, Mario and Palermo, Michele}, title = {Hydraulic structures engineering: An evolving science in a changing world}, series = {Wires Water}, volume = {8}, journal = {Wires Water}, number = {2}, publisher = {Wiley}, address = {Weinheim}, issn = {2049-1948}, doi = {10.1002/wat2.1505}, year = {2021}, language = {en} } @incollection{Dachwald2010, author = {Dachwald, Bernd}, title = {Solar sail dynamics and control}, series = {Encyclopedia of Aerospace Engineering}, booktitle = {Encyclopedia of Aerospace Engineering}, publisher = {Wiley}, address = {Hoboken}, doi = {10.1002/9780470686652.eae292}, year = {2010}, abstract = {Solar sails are large and lightweight reflective structures that are propelled by solar radiation pressure. This chapter covers their orbital and attitude dynamics and control. First, the advantages and limitations of solar sails are discussed and their history and development status is outlined. Because the dynamics of solar sails is governed by the (thermo-)optical properties of the sail film, the basic solar radiation pressure force models have to be described and compared before parameters to measure solar sail performance can be defined. The next part covers the orbital dynamics of solar sails for heliocentric motion, planetocentric motion, and motion at Lagrangian equilibrium points. Afterwards, some advanced solar radiation pressure force models are described, which allow to quantify the thrust force on solar sails of arbitrary shape, the effects of temperature, of light incidence angle, of surface roughness, and the effects of optical degradation of the sail film in the space environment. The orbital motion of a solar sail is strongly coupled to its rotational motion, so that the attitude control of these soft and flexible structures is very challenging, especially for planetocentric orbits that require fast attitude maneuvers. Finally, some potential attitude control methods are sketched and selection criteria are given.}, language = {en} } @article{HoffmannRohrbachUhletal.2022, author = {Hoffmann, Andreas and Rohrbach, Felix and Uhl, Matthias and Ceblin, Maximilian and Bauer, Thomas and Mallah, Marcel and Jacob, Timo and Heuermann, Holger and Kuehne, Alexander J. C.}, title = {Atmospheric pressure plasma-jet treatment of polyacrylonitrile-nonwovens—Stabilization and roll-to-roll processing}, series = {Journal of Applied Polymer Science}, volume = {139}, journal = {Journal of Applied Polymer Science}, number = {37}, publisher = {Wiley}, issn = {0021-8995 (Print)}, doi = {10.1002/app.52887}, pages = {1 -- 9}, year = {2022}, abstract = {Carbon nanofiber nonwovens represent a powerful class of materials with prospective application in filtration technology or as electrodes with high surface area in batteries, fuel cells, and supercapacitors. While new precursor-to-carbon conversion processes have been explored to overcome productivity restrictions for carbon fiber tows, alternatives for the two-step thermal conversion of polyacrylonitrile precursors into carbon fiber nonwovens are absent. In this work, we develop a continuous roll-to-roll stabilization process using an atmospheric pressure microwave plasma jet. We explore the influence of various plasma-jet parameters on the morphology of the nonwoven and compare the stabilized nonwoven to thermally stabilized samples using scanning electron microscopy, differential scanning calorimetry, and infrared spectroscopy. We show that stabilization with a non-equilibrium plasma-jet can be twice as productive as the conventional thermal stabilization in a convection furnace, while producing electrodes of comparable electrochemical performance.}, language = {en} } @article{AngermannGuenthnerHanssenetal.2022, author = {Angermann, Susanne and G{\"u}nthner, Roman and Hanssen, Henner and Lorenz, Georg and Braunisch, Matthias C. and Steubl, Dominik and Matschkal, Julia and Kemmner, Stephan and Hausinger, Renate and Block, Zenonas and Haller, Bernhard and Heemann, Uwe and Kotliar, Konstantin and Grimmer, Timo and Schmaderer, Christoph}, title = {Cognitive impairment and microvascular function in end-stage renal disease}, series = {International Journal of Methods in Psychiatric Research (MPR)}, volume = {31}, journal = {International Journal of Methods in Psychiatric Research (MPR)}, number = {2}, publisher = {Wiley}, issn = {1049-8931 (Print)}, doi = {10.1002/mpr.1909}, pages = {1 -- 10}, year = {2022}, abstract = {Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.}, language = {en} } @article{ElDeibButenwegKlinkel2021, author = {El-Deib, Khaled and Butenweg, Christoph and Klinkel, Sven}, title = {Erdbebennachweis von Mauerwerksbauten mit realistischen Modellen und erh{\"o}hten Verhaltensbeiwerten}, series = {Mauerwerk}, volume = {2021}, journal = {Mauerwerk}, number = {3}, editor = {Jesse, Dirk}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1022}, doi = {10.1002/dama.202110014}, pages = {110 -- 119}, year = {2021}, abstract = {Die Anwendung des linearen Nachweiskonzepts auf Mauerwerksbauten f{\"u}hrt dazu, dass bereits heute Standsicherheitsnachweise f{\"u}r Geb{\"a}ude mit {\"u}blichen Grundrissen in Gebieten mit moderaten Erdbebeneinwirkungen nicht mehr gef{\"u}hrt werden k{\"o}nnen. Diese Problematik wird sich in Deutschland mit der Einf{\"u}hrung kontinuierlicher probabilistischer Erdbebenkarten weiter versch{\"a}rfen. Aufgrund der Erh{\"o}hung der seismischen Einwirkungen, die sich vielerorts ergibt, ist es erforderlich, die vorhandenen, bislang nicht ber{\"u}cksichtigten Tragf{\"a}higkeitsreserven in nachvollziehbaren Nachweiskonzepten in der Baupraxis verf{\"u}gbar zu machen. Der vorliegende Beitrag stellt ein Konzept f{\"u}r die geb{\"a}udespezifische Ermittlung von erh{\"o}hten Verhaltensbeiwerten vor. Die Verhaltensbeiwerte setzen sich aus drei Anteilen zusammen, mit denen die Lastumverteilung im Grundriss, die Verformungsf{\"a}higkeit und Energiedissipation sowie die {\"U}berfestigkeiten ber{\"u}cksichtigt werden. F{\"u}r die rechnerische Ermittlung dieser drei Anteile wird ein nichtlineares Nachweiskonzept auf Grundlage von Pushover-Analysen vorgeschlagen, in denen die Interaktionen von W{\"a}nden und Geschossdecken durch einen Einspanngrad beschrieben werden. F{\"u}r die Bestimmung der Einspanngrade wird ein nichtlinearer Modellierungsansatz eingef{\"u}hrt, mit dem die Interaktion von W{\"a}nden und Decken abgebildet werden kann. Die Anwendung des Konzepts mit erh{\"o}hten geb{\"a}udespezifischen Verhaltensbeiwerten wird am Beispiel eines Mehrfamilienhauses aus Kalksandsteinen demonstriert. Die Ergebnisse der linearen Nachweise mit erh{\"o}hten Verhaltensbeiwerten f{\"u}r dieses Geb{\"a}ude liegen deutlich n{\"a}her an den Ergebnissen nichtlinearer Nachweise und somit bleiben {\"u}bliche Grundrisse in Erdbebengebieten mit den traditionellen linearen Rechenans{\"a}tzen nachweisbar.}, language = {de} } @article{FiedlerOrzadaFloeseretal.2022, author = {Fiedler, Thomas M. and Orzada, Stephan and Fl{\"o}ser, Martina and Rietsch, Stefan H. G. and Schmidt, Simon and Stelter, Jonathan K. and Wittrich, Marco and Quick, Harald H. and Bitz, Andreas and Ladd, Mark E.}, title = {Performance and safety assessment of an integrated transmitarray for body imaging at 7 T under consideration of specificabsorption rate, tissue temperature, and thermal dose}, series = {NMR in Biomedicine}, volume = {35}, journal = {NMR in Biomedicine}, number = {5}, publisher = {Wiley}, issn = {0952-3480 (Print)}, doi = {10.1002/nbm.4656}, pages = {1 -- 17}, year = {2022}, abstract = {In this study, the performance of an integrated body-imaging array for 7 T with 32 radiofrequency (RF) channels under consideration of local specific absorption rate (SAR), tissue temperature, and thermal dose limits was evaluated and the imaging performance was compared with a clinical 3 T body coil. Thirty-two transmit elements were placed in three rings between the bore liner and RF shield of the gradient coil. Slice-selective RF pulse optimizations for B1 shimming and spokes were performed for differently oriented slices in the body under consideration of realistic constraints for power and local SAR. To improve the B1+ homogeneity, safety assessments based on temperature and thermal dose were performed to possibly allow for higher input power for the pulse optimization than permissible with SAR limits. The results showed that using two spokes, the 7 T array outperformed the 3 T birdcage in all the considered regions of interest. However, a significantly higher SAR or lower duty cycle at 7 T is necessary in some cases to achieve similar B1+ homogeneity as at 3 T. The homogeneity in up to 50 cm-long coronal slices can particularly benefit from the high RF shim performance provided by the 32 RF channels. The thermal dose approach increases the allowable input power and the corresponding local SAR, in one example up to 100 W/kg, without limiting the exposure time necessary for an MR examination. In conclusion, the integrated antenna array at 7 T enables a clinical workflow for body imaging and comparable imaging performance to a conventional 3 T clinical body coil.}, language = {en} } @article{HeieisBoeckerD'Angeloetal.2023, author = {Heieis, Jule and B{\"o}cker, Jonas and D'Angelo, Olfa and Mittag, Uwe and Albracht, Kirsten and Sch{\"o}nau, Eckhard and Meyer, Andreas and Voigtmann, Thomas and Rittweger, J{\"o}rn}, title = {Curvature of gastrocnemius muscle fascicles as function of muscle-tendon complex length and contraction in humans}, series = {Physiological Reports}, volume = {11}, journal = {Physiological Reports}, number = {11}, publisher = {Wiley}, issn = {2051-817X}, doi = {10.14814/phy2.15739}, pages = {e15739, Seite 1-11}, year = {2023}, abstract = {It has been shown that muscle fascicle curvature increases with increasing contraction level and decreasing muscle-tendon complex length. The analyses were done with limited examination windows concerning contraction level, muscle-tendon complex length, and/or intramuscular position of ultrasound imaging. With this study we aimed to investigate the correlation between fascicle arching and contraction, muscle-tendon complex length and their associated architectural parameters in gastrocnemius muscles to develop hypotheses concerning the fundamental mechanism of fascicle curving. Twelve participants were tested in five different positions (90°/105°*, 90°/90°*, 135°/90°*, 170°/90°*, and 170°/75°*; *knee/ankle angle). They performed isometric contractions at four different contraction levels (5\%, 25\%, 50\%, and 75\% of maximum voluntary contraction) in each position. Panoramic ultrasound images of gastrocnemius muscles were collected at rest and during constant contraction. Aponeuroses and fascicles were tracked in all ultrasound images and the parameters fascicle curvature, muscle-tendon complex strain, contraction level, pennation angle, fascicle length, fascicle strain, intramuscular position, sex and age group were analyzed by linear mixed effect models. Mean fascicle curvature of the medial gastrocnemius increased with contraction level (+5 m-1 from 0\% to 100\%; p = 0.006). Muscle-tendon complex length had no significant impact on mean fascicle curvature. Mean pennation angle (2.2 m-1 per 10°; p < 0.001), inverse mean fascicle length (20 m-1 per cm-1; p = 0.003), and mean fascicle strain (-0.07 m-1 per +10\%; p = 0.004) correlated with mean fascicle curvature. Evidence has also been found for intermuscular, intramuscular, and sex-specific intramuscular differences of fascicle curving. Pennation angle and the inverse fascicle length show the highest predictive capacities for fascicle curving. Due to the strong correlations between pennation angle and fascicle curvature and the intramuscular pattern of curving we suggest for future studies to examine correlations between fascicle curvature and intramuscular fluid pressure.}, language = {en} } @article{FalkenbergKohnBottetal.2023, author = {Falkenberg, Fabian and Kohn, Sophie and Bott, Michael and Bongaerts, Johannes and Siegert, Petra}, title = {Biochemical characterisation of a novel broad pH spectrum subtilisin from Fictibacillus arsenicus DSM 15822ᵀ}, series = {FEBS Open Bio}, volume = {13}, journal = {FEBS Open Bio}, number = {11}, publisher = {Wiley}, address = {Hoboken, NJ}, issn = {2211-5463}, doi = {10.1002/2211-5463.13701}, pages = {2035 -- 2046}, year = {2023}, abstract = {Subtilisins from microbial sources, especially from the Bacillaceae family, are of particular interest for biotechnological applications and serve the currently growing enzyme market as efficient and novel biocatalysts. Biotechnological applications include use in detergents, cosmetics, leather processing, wastewater treatment and pharmaceuticals. To identify a possible candidate for the enzyme market, here we cloned the gene of the subtilisin SPFA from Fictibacillus arsenicus DSM 15822ᵀ (obtained through a data mining-based search) and expressed it in Bacillus subtilis DB104. After production and purification, the protease showed a molecular mass of 27.57 kDa and a pI of 5.8. SPFA displayed hydrolytic activity at a temperature optimum of 80 °C and a very broad pH optimum between 8.5 and 11.5, with high activity up to pH 12.5. SPFA displayed no NaCl dependence but a high NaCl tolerance, with decreasing activity up to concentrations of 5 m NaCl. The stability enhanced with increasing NaCl concentration. Based on its substrate preference for 10 synthetic peptide 4-nitroanilide substrates with three or four amino acids and its phylogenetic classification, SPFA can be assigned to the subgroup of true subtilisins. Moreover, SPFA exhibited high tolerance to 5\% (w/v) SDS and 5\% H₂O₂ (v/v). The biochemical properties of SPFA, especially its tolerance of remarkably high pH, SDS and H₂O₂, suggest it has potential for biotechnological applications.}, language = {en} } @article{CheenakulaPaulsenOttetal.2023, author = {Cheenakula, Dheeraja and Paulsen, Svea and Ott, Fabian and Gr{\"o}mping, Markus}, title = {Operational window of a deammonifying sludge for mainstream application in a municipal wastewater treatment plant}, series = {Water and Environment Journal}, journal = {Water and Environment Journal}, number = {Early View}, publisher = {Wiley}, address = {Chichester}, issn = {1747-6593}, doi = {10.1111/wej.12898}, pages = {1 -- 12}, year = {2023}, abstract = {The present work aimed to study the mainstream feasibility of the deammonifying sludge of side stream of municipal wastewater treatment plant (MWWTP) in Kaster, Germany. For this purpose, the deammonifying sludge available at the side stream was investigated for nitrogen (N) removal with respect to the operational factors temperature (15-30°C), pH value (6.0-8.0) and chemical oxygen demand (COD)/N ratio (≤1.5-6.0). The highest and lowest N-removal rates of 0.13 and 0.045 kg/(m³ d) are achieved at 30 and 15°C, respectively. Different conditions of pH and COD/N ratios in the SBRs of Partial nitritation/anammox (PN/A) significantly influenced both the metabolic processes and associated N-removal rates. The scientific insights gained from the current work signifies the possibility of mainstream PN/A at WWTPs. The current study forms a solid basis of operational window for the upcoming semi-technical trails to be conducted prior to the full-scale mainstream PN/A at WWTP Kaster and WWTPs globally.}, language = {en} } @article{KraffBitzDammannetal.2010, author = {Kraff, Oliver and Bitz, Andreas and Dammann, Philipp and Ladd, Susanne C. and Ladd, Mark E. and Quick, Harald H.}, title = {An eight-channel transmit/receive multipurpose coil for musculoskeletal MR imaging at 7 T}, series = {Medical Physics}, volume = {37}, journal = {Medical Physics}, number = {12}, publisher = {Wiley}, address = {Hoboken, NJ}, issn = {2473-4209}, doi = {10.1118/1.3517176}, pages = {6368 -- 6376}, year = {2010}, abstract = {Purpose: MRI plays a leading diagnostic role in assessing the musculoskeletal (MSK) system and is well established for most questions at clinically used field strengths (up to 3 T). However, there are still limitations in imaging early stages of cartilage degeneration, very fine tendons and ligaments, or in locating nerve lesions, for example. 7 T MRI of the knee has already received increasing attention in the current published literature, but there is a strong need to develop new radiofrequency (RF) coils to assess more regions of the MSK system. In this work, an eight-channel transmit/receive RF array was built as a multipurpose coil for imaging some of the thus far neglected regions. An extensive coil characterization protocol and first in vivo results of the human wrist, shoulder, elbow, knee, and ankle imaged at 7 T will be presented. Methods: Eight surface loop coils with a dimension ofurn:x-wiley:00942405:media:mp7176:mp7176-math-0001 were machined from FR4 circuit board material. To facilitate easy positioning, two coil clusters, each with four loop elements, were combined to one RF transmit/receive array. An overlapped and shifted arrangement of the coil elements was chosen to reduce the mutual inductance between neighboring coils. A phantom made of body-simulating liquid was used for tuning and matching on the bench. Afterward, the S-parameters were verified on a human wrist, elbow, and shoulder. For safety validation, a detailed compliance test was performed including full wave simulations of the RF field distribution and the corresponding specific absorption rate (SAR) for all joints. In vivo images of four volunteers were assessed with gradient echo and spin echo sequences modified to obtain optimal image contrast, full anatomic coverage, and the highest spatial resolution within a reasonable acquisition time. The performance of the RF coil was additionally evaluated by in vivo B1 mapping. Results: A comparison of B1 per unit power, flip angle distribution, and anatomic images showed a fairly homogeneous excitation for the smaller joints (elbow, wrist, and ankle), while for the larger joints, the shoulder and especially the knee, B1 inhomogeneities and limited penetration depth were more pronounced. However, the greater part of the shoulder joint could be imaged.In vivo images rendered very fine anatomic details such as fascicles of the median nerve and the branching of the nerve bundles. High-resolution images of cartilage, labrum, and tendons could be acquired. Additionally, turbo spin echo (TSE) and inversion recovery sequences performed very well. Conclusions: This study demonstrates that the concept of two four-channel transmit/receive RF arrays can be used as a multipurpose coil for high-resolutionin vivo MR imaging of the musculoskeletal system at 7 T. Not only gradient echo but also typical clinical and SAR-intensive sequences such as STIR and TSE performed well. Imaging of small structures and peripheral nerves could in particular benefit from this technique.}, language = {en} } @article{TippkoetterRoikaewUlberetal.2010, author = {Tippk{\"o}tter, Nils and Roikaew, Wipa and Ulber, Roland and Hoffmann, Alexander and Denzler, Hans-J{\"o}rg and Buchholz, Heinrich}, title = {Paracoccus denitrificans for the effluent recycling during continuous denitrification of liquid food}, series = {Biotechnology Progress}, volume = {26}, journal = {Biotechnology Progress}, number = {3}, publisher = {Wiley}, address = {Hoboken, NJ}, issn = {8756-7938}, doi = {10.1002/btpr.384}, pages = {756 -- 762}, year = {2010}, abstract = {Nitrate is an undesirable component of several foods. A typical case of contamination with high nitrate contents is whey concentrate, containing nitrate in concentrations up to 25 l. The microbiological removal of nitrate by Paracoccus denitrificans under formation of harmless nitrogen in combination with a cell retention reactor is described here. Focus lies on the resource-conserving design of a microbal denitrification process. Two methods are compared. The application of polyvinyl alcohol-immobilized cells, which can be applied several times in whey feed, is compared with the implementation of a two step denitrification system. First, the whey concentrate's nitrate is removed by ion exchange and subsequently the eluent regenerated by microorganisms under their retention by crossflow filtration. Nitrite and nitrate concentrations were determined by reflectometric color measurement with a commercially available Reflectoquant® device. Correction factors for these media had to be determined. During the pilot development, bioreactors from 4 to 250 mg·L-1 and crossflow units with membrane areas from 0.02 to 0.80 m2 were examined. Based on the results of the pilot plants, a scaling for the exemplary process of denitrifying 1,000 tons per day is discussed.}, language = {en} } @article{PieperKlein2010, author = {Pieper, Martin and Klein, Peter}, title = {Numerical solution of the heat equation with non-linear, time derivative-dependent source term}, series = {International Journal for Numerical Methods in Engineering}, volume = {84}, journal = {International Journal for Numerical Methods in Engineering}, number = {10}, publisher = {Wiley}, address = {Chichester}, issn = {0029-5981}, doi = {10.1002/nme.2937}, pages = {1205 -- 1221}, year = {2010}, abstract = {The mathematical modeling of heat conduction with adsorption effects in coated metal structures yields the heat equation with piecewise smooth coefficients and a new kind of source term. This term is special, because it is non-linear and furthermore depends on a time derivative. In our approach we reformulated this as a new problem for the usual heat equation, without source term but with a new non-linear coefficient. We gave an existence and uniqueness proof for the weak solution of the reformulated problem. To obtain a numerical solution, we developed a semi-implicit and a fully implicit finite volume method. We compared these two methods theoretically as well as numerically. Finally, as practical application, we simulated the heat conduction in coated aluminum fibers with adsorption in the zeolite coating. Copyright © 2010 John Wiley \& Sons, Ltd.}, language = {en} } @article{HaselgruberMautnerThiele2010, author = {Haselgruber, Nikolaus and Mautner, Karin and Thiele, Jan}, title = {Usage Space Analysis for Reliability Testing}, series = {Quality and Reliability Engineering International}, volume = {26}, journal = {Quality and Reliability Engineering International}, number = {8}, publisher = {Wiley}, address = {New York}, issn = {1099-1638}, doi = {10.1002/qre.1155}, pages = {877 -- 885}, year = {2010}, abstract = {During the development process of a complex technical product, one widely used and important technique is accelerated testing where the applied stress on a component is chosen to exceed the reference stress, i.e. the stress encountered in field operation, in order to reduce the time to failure. For that, the reference stress has to be known. Since a complex technical product may fail regarding numerous failure modes, stress in general is highly dimensional rather than scalar. In addition, customers use their products individually, i.e. field operation should be described by a distribution rather than by one scalar stress value. In this paper, a way to span the customer usage space is shown. It allows the identification of worst case reference stress profiles in significantly reduced dimensions with minimal loss of information. The application example shows that even for a complex product like a combustion engine, stress information can be compressed significantly. With low measurement effort it turned out that only three reference stress cycles were sufficient to cover a broad range of customer stress variety.}, language = {en} }