@article{SchoenrockMuckeltHastermannetal.2024,
  author    = {Schoenrock, Britt and Muckelt, Paul E. and Hastermann, Maria and Albracht, Kirsten and MacGregor, Robert and Martin, David and Gunga, Hans-Christian and Salanova, Michele and Stokes, Maria J. and Warner, Martin B. and Blottner, Dieter},
  title     = {Muscle stiffness indicating mission crew health in space},
  series = {Scientific Reports},
  volume    = {14},
  journal   = {Scientific Reports},
  number    = {Article number: 4196},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-024-54759-6},
  pages     = {13 Seiten},
  year      = {2024},
  abstract  = {Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes.},
  language  = {en}
}
@article{LiphardtFernandezGonzaloAlbrachtetal.2023,
  author    = {Liphardt, Anna-Maria and Fernandez-Gonzalo, Rodrigo and Albracht, Kirsten and Rittweger, J{\"o}rn and Vico, Laurence},
  title     = {Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration},
  series = {npj Microgravity},
  volume    = {9},
  journal   = {npj Microgravity},
  number    = {Article number: 9},
  publisher = {Springer Nature},
  issn      = {2373-8065},
  doi       = {10.1038/s41526-023-00258-3},
  pages     = {1 -- 9},
  year      = {2023},
  abstract  = {Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper "Human Physiology - Musculoskeletal system", this perspective highlights unmet needs and suggests new avenues for future studies in musculoskeletal research to enable crewed exploration missions. The musculoskeletal system is essential for sustaining physical function and energy metabolism, and the maintenance of health during exploration missions, and consequently mission success, will be tightly linked to musculoskeletal function. Data collection from current space missions from pre-, during-, and post-flight periods would provide important information to understand and ultimately offset musculoskeletal alterations during long-term spaceflight. In addition, understanding the kinetics of the different components of the musculoskeletal system in parallel with a detailed description of the molecular mechanisms driving these alterations appears to be the best approach to address potential musculoskeletal problems that future exploratory-mission crew will face. These research efforts should be accompanied by technical advances in molecular and phenotypic monitoring tools to provide in-flight real-time feedback.},
  language  = {en}
}
@incollection{GohTopcuMadabhushietal.2023,
  author    = {Goh, Kheng Lim and Top{\c{c}}u, Murat and Madabhushi, Gopal S. P. and Staat, Manfred},
  title     = {Collagen fibril reinforcement in connective tissue extracellular matrices},
  series = {Handbook of the extracellular matrix},
  booktitle = {Handbook of the extracellular matrix},
  editor    = {Maia, Fatima Raquel Azevedo and Miguel Oliveira, J. and Reis, Rui L.},
  publisher = {Springer Nature},
  address   = {Cham},
  isbn      = {978-3-030-92090-6 (Print)},
  doi       = {10.1007/978-3-030-92090-6_6-1},
  pages     = {1 -- 20},
  year      = {2023},
  abstract  = {The connective tissues such as tendons contain an extracellular matrix (ECM) comprising collagen fibrils scattered within the ground substance. These fibrils are instrumental in lending mechanical stability to tissues. Unfortunately, our understanding of how collagen fibrils reinforce the ECM remains limited, with no direct experimental evidence substantiating current theories. Earlier theoretical studies on collagen fibril reinforcement in the ECM have relied predominantly on the assumption of uniform cylindrical fibers, which is inadequate for modelling collagen fibrils, which possessed tapered ends. Recently, Top{\c{c}}u and colleagues published a paper in the International Journal of Solids and Structures, presenting a generalized shear-lag theory for the transfer of elastic stress between the matrix and fibers with tapered ends. This paper is a positive step towards comprehending the mechanics of the ECM and makes a valuable contribution to formulating a complete theory of collagen fibril reinforcement in the ECM.},
  language  = {en}
}
@article{TrappLammersEngudaretal.2023,
  author    = {Trapp, Svenja and Lammers, Tom and Engudar, Gokce and Hoehr, Cornelia and Denkova, Antonia G. and Paulßen, Elisabeth and de Kruijff, Robin M.},
  title     = {Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop},
  series = {EJNMMI Radiopharmacy and Chemistry},
  volume    = {2023},
  journal   = {EJNMMI Radiopharmacy and Chemistry},
  number    = {8, Article number: 9},
  publisher = {Springer Nature},
  issn      = {2365-421X},
  doi       = {10.1186/s41181-023-00195-2},
  pages     = {1 -- 14},
  year      = {2023},
  language  = {en}
}
@article{RossiWinandsButenweg2022,
  author    = {Rossi, Leonardo and Winands, Mark H. M. and Butenweg, Christoph},
  title     = {Monte Carlo Tree Search as an intelligent search tool in structural design problems},
  series = {Engineering with Computers : An International Journal for Simulation-Based Engineering},
  volume    = {38},
  journal   = {Engineering with Computers : An International Journal for Simulation-Based Engineering},
  number    = {4},
  editor    = {Zhang, Jessica},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1435-5663},
  doi       = {10.1007/s00366-021-01338-2},
  pages     = {3219 -- 3236},
  year      = {2022},
  abstract  = {Monte Carlo Tree Search (MCTS) is a search technique that in the last decade emerged as a major breakthrough for Artificial Intelligence applications regarding board- and video-games. In 2016, AlphaGo, an MCTS-based software agent, outperformed the human world champion of the board game Go. This game was for long considered almost infeasible for machines, due to its immense search space and the need for a long-term strategy. Since this historical success, MCTS is considered as an effective new approach for many other scientific and technical problems. Interestingly, civil structural engineering, as a discipline, offers many tasks whose solution may benefit from intelligent search and in particular from adopting MCTS as a search tool. In this work, we show how MCTS can be adapted to search for suitable solutions of a structural engineering design problem. The problem consists of choosing the load-bearing elements in a reference reinforced concrete structure, so to achieve a set of specific dynamic characteristics. In the paper, we report the results obtained by applying both a plain and a hybrid version of single-agent MCTS. The hybrid approach consists of an integration of both MCTS and classic Genetic Algorithm (GA), the latter also serving as a term of comparison for the results. The study's outcomes may open new perspectives for the adoption of MCTS as a design tool for civil engineers.},
  language  = {en}
}
@article{MorandiButenwegBreisetal.2022,
  author    = {Morandi, Paolo and Butenweg, Christoph and Breis, Khaled and Beyer, Katrin and Magenes, Guido},
  title     = {Latest findings on the behaviour factor q for the seismic design of URM buildings},
  series = {Bulletin of Earthquake Engineering},
  volume    = {20},
  journal   = {Bulletin of Earthquake Engineering},
  number    = {11},
  editor    = {Ansal, Atilla},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1573-1456},
  doi       = {10.1007/s10518-022-01419-7},
  pages     = {5797 -- 5848},
  year      = {2022},
  abstract  = {Recent earthquakes as the 2012 Emilia earthquake sequence showed that recently built unreinforced masonry (URM) buildings behaved much better than expected and sustained, despite the maximum PGA values ranged between 0.20-0.30 g, either minor damage or structural damage that is deemed repairable. Especially low-rise residential and commercial masonry buildings with a code-conforming seismic design and detailing behaved in general very well without substantial damages. The low damage grades of modern masonry buildings that was observed during this earthquake series highlighted again that codified design procedures based on linear analysis can be rather conservative. Although advances in simulation tools make nonlinear calculation methods more readily accessible to designers, linear analyses will still be the standard design method for years to come. The present paper aims to improve the linear seismic design method by providing a proper definition of the q-factor of URM buildings. These q-factors are derived for low-rise URM buildings with rigid diaphragms which represent recent construction practise in low to moderate seismic areas of Italy and Germany. The behaviour factor components for deformation and energy dissipation capacity and for overstrength due to the redistribution of forces are derived by means of pushover analyses. Furthermore, considerations on the behaviour factor component due to other sources of overstrength in masonry buildings are presented. As a result of the investigations, rationally based values of the behaviour factor q to be used in linear analyses in the range of 2.0-3.0 are proposed.},
  language  = {en}
}
@article{FunkeEschRoosen2022,
  author    = {Funke, Harald and Esch, Thomas and Roosen, Petra},
  title     = {Powertrain Adaptions for LPG Usage in General Aviation},
  series = {MTZ worldwide},
  volume    = {2022},
  journal   = {MTZ worldwide},
  number    = {83},
  publisher = {Springer Nature},
  address   = {Basel},
  doi       = {10.1007/s38313-021-0756-6},
  pages     = {58 -- 62},
  year      = {2022},
  abstract  = {In general aviation, too, it is desirable to be able to operate existing internal combustion engines with fuels that produce less CO₂ than Avgas 100LL being widely used today It can be assumed that, in comparison, the fuels CNG, LPG or LNG, which are gaseous under normal conditions, produce significantly lower emissions. Necessary propulsion system adaptations were investigated as part of a research project at Aachen University of Applied Sciences.},
  language  = {en}
}
@inproceedings{BlankeSchmidtGoettscheetal.2022,
  author    = {Blanke, Tobias and Schmidt, Katharina S. and G{\"o}ttsche, Joachim and D{\"o}ring, Bernd and Frisch, J{\´e}r{\^o}me and van Treeck, Christoph},
  title     = {Time series aggregation for energy system design: review and extension of modelling seasonal storages},
  series = {Energy Informatics},
  volume    = {5},
  booktitle = {Energy Informatics},
  number    = {1, Article number: 17},
  editor    = {Weidlich, Anke and Neumann, Dirk and Gust, Gunther and Staudt, Philipp and Sch{\"a}fer, Mirko},
  publisher = {Springer Nature},
  issn      = {2520-8942},
  doi       = {10.1186/s42162-022-00208-5},
  pages     = {1 -- 14},
  year      = {2022},
  abstract  = {Using optimization to design a renewable energy system has become a computationally demanding task as the high temporal fluctuations of demand and supply arise within the considered time series. The aggregation of typical operation periods has become a popular method to reduce effort. These operation periods are modelled independently and cannot interact in most cases. Consequently, seasonal storage is not reproducible. This inability can lead to a significant error, especially for energy systems with a high share of fluctuating renewable energy. The previous paper, "Time series aggregation for energy system design: Modeling seasonal storage", has developed a seasonal storage model to address this issue. Simultaneously, the paper "Optimal design of multi-energy systems with seasonal storage" has developed a different approach. This paper aims to review these models and extend the first model. The extension is a mathematical reformulation to decrease the number of variables and constraints. Furthermore, it aims to reduce the calculation time while achieving the same results.},
  language  = {en}
}
@inproceedings{VeettilRakshitSchopenetal.2022,
  author    = {Veettil, Yadu Krishna Morassery and Rakshit, Shantam and Schopen, Oliver and Kemper, Hans and Esch, Thomas and Shabani, Bahman},
  title     = {Automated Control System Strategies to Ensure Safety of PEM Fuel Cells Using Kalman Filters},
  series = {Proceedings of the 7th International Conference and Exhibition on Sustainable Energy and Advanced Materials (ICE-SEAM 2021), Melaka, Malaysia},
  booktitle = {Proceedings of the 7th International Conference and Exhibition on Sustainable Energy and Advanced Materials (ICE-SEAM 2021), Melaka, Malaysia},
  editor    = {Bin Abdollah, Mohd Fadzli and Amiruddin, Hilmi and Singh, Amrik Singh Phuman and Munir, Fudhail Abdul and Ibrahim, Asriana},
  publisher = {Springer Nature},
  address   = {Singapore},
  isbn      = {978-981-19-3178-9},
  issn      = {2195-4356},
  doi       = {10.1007/978-981-19-3179-6_55},
  pages     = {296 -- 299},
  year      = {2022},
  abstract  = {Having well-defined control strategies for fuel cells, that can efficiently detect errors and take corrective action is critically important for safety in all applications, and especially so in aviation. The algorithms not only ensure operator safety by monitoring the fuel cell and connected components, but also contribute to extending the health of the fuel cell, its durability and safe operation over its lifetime. While sensors are used to provide peripheral data surrounding the fuel cell, the internal states of the fuel cell cannot be directly measured. To overcome this restriction, Kalman Filter has been implemented as an internal state observer. Other safety conditions are evaluated using real-time data from every connected sensor and corrective actions automatically take place to ensure safety. The algorithms discussed in this paper have been validated thorough Model-in-the-Loop (MiL) tests as well as practical validation at a dedicated test bench.},
  language  = {en}
}
@inproceedings{TamaldinMansorMatYaminetal.2022,
  author    = {Tamaldin, Noreffendy and Mansor, Muhd Rizuan and Mat Yamin, Ahmad Kamal and Bin Abdollah, Mohd Fazli and Esch, Thomas and Tonoli, Andrea and Reisinger, Karl Heinz and Sprenger, Hanna and Razuli, Hisham},
  title     = {Development of UTeM United Future Fuel Design Training Center Under Erasmus+ United Program},
  series = {Proceedings of the 7th International Conference and Exhibition on Sustainable Energy and Advanced Materials (ICE-SEAM 2021), Melaka, Malaysia},
  booktitle = {Proceedings of the 7th International Conference and Exhibition on Sustainable Energy and Advanced Materials (ICE-SEAM 2021), Melaka, Malaysia},
  editor    = {Bin Abdollah, Mohd Fadzli and Amiruddin, Hilmi and Singh, Amrik Singh Phuman and Munir, Fudhail Abdul and Ibrahim, Asriana},
  publisher = {Springer Nature},
  address   = {Singapore},
  isbn      = {978-981-19-3178-9},
  issn      = {2195-4356},
  doi       = {10.1007/978-981-19-3179-6_50},
  pages     = {274 -- 278},
  year      = {2022},
  abstract  = {The industrial revolution IR4.0 era have driven many states of the art technologies to be introduced especially in the automotive industry. The rapid development of automotive industries in Europe have created wide industry gap between European Union (EU) and developing countries such as in South-East Asia (SEA). Indulging this situation, FH Joanneum, Austria together with European partners from FH Aachen, Germany and Politecnico Di Torino, Italy is taking initiative to close the gap utilizing the Erasmus+ United grant from EU. A consortium was founded to engage with automotive technology transfer using the European ramework to Malaysian, Indonesian and Thailand Higher Education Institutions (HEI) as well as automotive industries. This could be achieved by establishing Engineering Knowledge Transfer Unit (EKTU) in respective SEA institutions guided by the industry partners in their respective countries. This EKTU could offer updated, innovative, and high-quality training courses to increase graduate's employability in higher education institutions and strengthen relations between HEI and the wider economic and social environment by addressing Universityindustry cooperation which is the regional priority for Asia. It is expected that, the Capacity Building Initiative would improve the quality of higher education and enhancing its relevance for the labor market and society in the SEA partners. The outcome of this project would greatly benefit the partners in strong and complementary partnership targeting the automotive industry and enhanced larger scale international cooperation between the European and SEA partners. It would also prepare the SEA HEI in sustainable partnership with Automotive industry in the region as a mean of income generation in the future.},
  language  = {en}
}