@incollection{MeskourisButenwegHinzenetal.2019, author = {Meskouris, Konstantin and Butenweg, Christoph and Hinzen, Klaus-G. and H{\"o}ffer, R{\"u}diger}, title = {Stochasticity of Wind Processes and Spectral Analysis of Structural Gust Response}, series = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, booktitle = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-57550-5 (Online)}, doi = {10.1007/978-3-662-57550-5_3}, pages = {153 -- 196}, year = {2019}, abstract = {Wind loads have great impact on many engineering structures. Wind storms often cause irreparable damage to the buildings which are exposed to it. Along with the earthquakes, wind represents one of the most common environmental load on structures and is relevant for limit state design. Modern wind codes indicate calculation procedures allowing engineers to deal with structural systems, which are susceptible to conduct wind-excited oscillations. In the codes approximate formulas for wind buffeting are specified which relate the dynamic problem to rather abstract parameter functions. The complete theory behind is not visible in order to simplify the applicability of the procedures. This chapter derives the underlying basic relations of the spectral method for wind buffeting and explains the main important applications of it in order to elucidate part of the theoretical background of computations after the new codes. The stochasticity of the wind processes is addressed, and the analysis of analytical as well as measurement based power spectra is outlined. Short MATLAB codes are added to the Appendix 3 which carry out the computation of a single sided auto-spectrum from a statistically stationary, discrete stochastic process. Two examples are presented.}, language = {en} } @incollection{DigelAkimbekovKistaubayevaetal.2018, author = {Digel, Ilya and Akimbekov, Nuraly S. and Kistaubayeva, Aida and Zhubanova, Azhar A.}, title = {Microbial Sampling from Dry Surfaces: Current Challenges and Solutions}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_19}, pages = {421 -- 456}, year = {2018}, abstract = {Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms' recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling.}, language = {en} } @incollection{StaatHeitzer2003, author = {Staat, Manfred and Heitzer, M.}, title = {Basis reduction technique for limit and shakedown problems}, series = {Numerical Methods for Limit and Shakedown Analysis. Deterministic and Probabilistic Approach. NIC Series Vol. 15 / Ed. by Staat, M.; Heitzer, M.}, booktitle = {Numerical Methods for Limit and Shakedown Analysis. Deterministic and Probabilistic Approach. NIC Series Vol. 15 / Ed. by Staat, M.; Heitzer, M.}, publisher = {John von Neumann Institute for Computing (NIC)}, address = {J{\"u}lich}, isbn = {3-00-010001-6}, url = {http://nbn-resolving.de/urn:nbn:de:0001-2018112115}, pages = {1 -- 55}, year = {2003}, language = {en} } @incollection{StriebingMuellerSchraudneretal.2022, author = {Striebing, Clemens and M{\"u}ller, J{\"o}rg and Schraudner, Martina and Gewinner, Irina Valerie and Guerrero Morales, Patricia and Hochfeld, Katharina and Hoffman, Shekinah and Kmec, Julie A. and Nguyen, Huu Minh and Schneider, Jannick and Sheridan, Jennifer and Steuer-Dankert, Linda and Trimble O'Connor, Lindsey and Vandevelde-Rougale, Agn{\`e}s}, title = {Promoting diversity and combatting discrimination in research organizations: a practitioner's guide}, series = {Diversity and discrimination in research organizations}, booktitle = {Diversity and discrimination in research organizations}, publisher = {Emerald Publishing Limited}, address = {Bingley}, isbn = {978-1-80117-959-1 (Print)}, doi = {10.1108/978-1-80117-956-020221012}, pages = {421 -- 442}, year = {2022}, abstract = {The essay is addressed to practitioners in research management and from academic leadership. It describes which measures can contribute to creating an inclusive climate for research teams and preventing and effectively dealing with discrimination. The practical recommendations consider the policy and organizational levels, as well as the individual perspective of research managers. Following a series of basic recommendations, six lessons learned are formulated, derived from the contributions to the edited collection on "Diversity and Discrimination in Research Organizations."}, language = {en} } @incollection{SteuerDankertLeichtScholten2022, author = {Steuer-Dankert, Linda and Leicht-Scholten, Carmen}, title = {Perceiving diversity : an explorative approach in a complex research organization.}, series = {Diversity and discrimination in research organizations}, booktitle = {Diversity and discrimination in research organizations}, publisher = {Emerald Publishing Limited}, address = {Bingley}, isbn = {978-1-80117-959-1 (Print)}, doi = {10.1108/978-1-80117-956-020221010}, pages = {365 -- 392}, year = {2022}, abstract = {Diversity management is seen as a decisive factor for ensuring the development of socially responsible innovations (Beacham and Shambaugh, 2011; Sonntag, 2014; L{\´o}pez, 2015; Uebernickel et al., 2015). However, many diversity management approaches fail due to a one-sided consideration of diversity (Thomas and Ely, 2019) and a lacking linkage between the prevailing organizational culture and the perception of diversity in the respective organization. Reflecting the importance of diverse perspectives, research institutions have a special responsibility to actively deal with diversity, as they are publicly funded institutions that drive socially relevant development and educate future generations of developers, leaders and decision-makers. Nevertheless, only a few studies have so far dealt with the influence of the special framework conditions of the science system on diversity management. Focusing on the interdependency of the organizational culture and diversity management especially in a university research environment, this chapter aims in a first step to provide a theoretical perspective on the framework conditions of a complex research organization in Germany in order to understand the system-specific factors influencing diversity management. In a second step, an exploratory cluster analysis is presented, investigating the perception of diversity and possible influencing factors moderating this perception in a scientific organization. Combining both steps, the results show specific mechanisms and structures of the university research environment that have an impact on diversity management and rigidify structural barriers preventing an increase of diversity. The quantitative study also points out that the management level takes on a special role model function in the scientific system and thus has an influence on the perception of diversity. Consequently, when developing diversity management approaches in research organizations, it is necessary to consider the top-down direction of action, the special nature of organizational structures in the university research environment as well as the special role of the professorial level as role model for the scientific staff.}, language = {en} } @incollection{OsterhageBialonskiStanieketal.2008, author = {Osterhage, Hannes and Bialonski, Stephan and Staniek, Matth{\"a}us and Schindler, Kaspar and Wagner, Tobias and Elger, Christian E. and Lehnertz, Klaus}, title = {Bivariate and multivariate time series analysis techniques and their potential impact for seizure prediction}, series = {Seizure Prediction in Epilepsy: From Basic Mechanisms to Clinical Applications}, booktitle = {Seizure Prediction in Epilepsy: From Basic Mechanisms to Clinical Applications}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {978-3-527-62519-2}, doi = {10.1002/9783527625192.ch15}, pages = {189 -- 208}, year = {2008}, language = {en} } @incollection{LeichtScholtenSteuerDankert2020, author = {Leicht-Scholten, Carmen and Steuer-Dankert, Linda}, title = {Educating engineers for socially responsible solutions through design thinking}, series = {Design thinking in higher education: interdisciplinary encounters}, booktitle = {Design thinking in higher education: interdisciplinary encounters}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-15-5780-4}, doi = {10.1007/978-981-15-5780-4}, pages = {229 -- 246}, year = {2020}, abstract = {There is a broad international discussion about rethinking engineering education in order to educate engineers to cope with future challenges, and particularly the sustainable development goals. In this context, there is a consensus about the need to shift from a mostly technical paradigm to a more holistic problem-based approach, which can address the social embeddedness of technology in society. Among the strategies suggested to address this social embeddedness, design thinking has been proposed as an essential complement to engineering precisely for this purpose. This chapter describes the requirements for integrating the design thinking approach in engineering education. We exemplify the requirements and challenges by presenting our approach based on our course experiences at RWTH Aachen University. The chapter first describes the development of our approach of integrating design thinking in engineering curricula, how we combine it with the Sustainable Development Goals (SDG) as well as the role of sustainability and social responsibility in engineering. Secondly, we present the course "Expanding Engineering Limits: Culture, Diversity, and Gender" at RWTH Aachen University. We describe the necessity to theoretically embed the method in social and cultural context, giving students the opportunity to reflect on cultural, national, or individual "engineering limits," and to be able to overcome them using design thinking as a next step for collaborative project work. The paper will suggest that the successful implementation of design thinking as a method in engineering education needs to be framed and contextualized within Science and Technology Studies (STS).}, language = {en} } @incollection{BraunBouckeHankeetal.2003, author = {Braun, Carsten and Boucke, Alexander and Hanke, M. and Karavas, Alexandros and Ballmann, Josef}, title = {Prediction of the model deformation of a high speed transport aircraft type wing by direct aeroelastic simulation}, series = {High performance computing in science and engineering '03. Transactions of the High Performance Computing Center Stuttgart (HLRS) 2003 / Eds.: Egon Krause ...}, booktitle = {High performance computing in science and engineering '03. Transactions of the High Performance Computing Center Stuttgart (HLRS) 2003 / Eds.: Egon Krause ...}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-40850-5}, pages = {331 -- 342}, year = {2003}, language = {de} } @incollection{StollenwerkFranzkeMaureretal.2023, author = {Stollenwerk, Dominik and Franzke, Till and Maurer, Florian and Reinkensmeier, Sebastian and Kim, Franken and Tambornino, Philipp and Haas, Florian and Rieke, Christian and Hermanuz, Andreas and Borchert, J{\"o}rg and Ritz, Thomas and Sander, Volker}, title = {Smarte Lades{\"a}ulen : Netz- und Marktdienliches {\"o}ffentliches Laden}, series = {Towards the New Normal in Mobility : Technische und betriebswirtschaftliche Aspekte}, booktitle = {Towards the New Normal in Mobility : Technische und betriebswirtschaftliche Aspekte}, editor = {Proff, Heike}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-658-39437-0 (Print)}, doi = {10.1007/978-3-658-39438-7_18}, pages = {287 -- 304}, year = {2023}, abstract = {Stand 01.01.2022 sind in Deutschland 618.460 elektrisch angetriebene KFZ zugelassen. Insgesamt sind derzeit 48.540.878 KFZ zugelassen, was einer Elektromobilit{\"a}tsquote von ca. 1,2 \% entspricht. Derzeit werden Elektromobile {\"u}ber Ladestationen oder Steckdosen mit dem Stromnetz verbunden und {\"u}blicherweise mit der vollen Ladekapazit{\"a}t des Anschlusses aufgeladen, bis das Batteriemanagementsystem des Fahrzeugs abh{\"a}ngig vom Ladezustand der Batterie die Ladeleistung reduziert.}, language = {de} } @incollection{Krause2019, author = {Krause, Thomas}, title = {Schalung und Ger{\"u}ste}, series = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, booktitle = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-23127-9 (Online)}, doi = {10.1007/978-3-658-23127-9_9}, pages = {241 -- 253}, year = {2019}, abstract = {Die grunds{\"a}tzliche Planung von Schalungsaufgaben wird heute in der Regel im Rahmen der Arbeitsvorbereitung von den entsprechenden Stabsabteilungen oder als Serviceleistung von den Schalungsherstellern mit Anwendung von spezieller Software und den technischen Unterlagen f{\"u}r die jeweiligen Schalungsger{\"a}te durchgef{\"u}hrt. Diese Programme und technischen Unterlagen stehen in der Regel auch den Mitarbeitern in der Bauleitung zur Verf{\"u}gung, werden dort aber eher seltener genutzt. Zur Anwendung auf der Baustelle stellen die Schalungshersteller neben den technischen Unterlagen Bemessungstabellen zur Verf{\"u}gung, welche die Auswahl und Dimensionierung einzelner Schalungen wesentlich erleichtern. Die nachfolgend aufgef{\"u}hrten Beispiele aus dem Bereich Schalung und Ger{\"u}ste beschreiben Aufgaben, die im Baustellenbetrieb auf die Bauleitung zu kommen k{\"o}nnen und auch ohne Unterst{\"u}tzung einer Stabsabteilung gel{\"o}st werden k{\"o}nnen.}, language = {de} } @incollection{Schloesser2016, author = {Schl{\"o}sser, Karl Helmut}, title = {Arbeitsvorbereitung und Ablaufplanung}, series = {Zahlentafeln f{\"u}r den Baubetrieb}, booktitle = {Zahlentafeln f{\"u}r den Baubetrieb}, edition = {9., {\"u}berarb. und aktual. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-02838-1 (Online)}, doi = {10.1007/978-3-658-02838-1_8}, pages = {1029 -- 1067}, year = {2016}, abstract = {Kosten- und Verfahrensvergleiche k{\"o}nnen dabei zur Ermittlung des f{\"u}r die Aufgabe geeignetsten Bauverfahren f{\"u}hren. F{\"u}r die sich daran anschließende Ablaufplanung werden die verschiedenen graphischen sowie rechnerischen Instrumente (Terminliste und Taktplan, Balkenplan, Weg-Zeit-Diagramm und Netzplan) erl{\"a}utert und anhand von Beispielen vertieft. Schließlich wird ein im Rahmen der Arbeits- und Nachkalkulation vorzunehmender Soll-Ist-Vergleich mit Hilfe des Bauarbeitsschl{\"u}ssels (BAS) zur {\"U}berpr{\"u}fung der Aufwands- und Leistungswerte dargestellt.}, language = {de} } @incollection{Ulke2016, author = {Ulke, Bernd}, title = {Boden, Baugrube, Verbau}, series = {Zahlentafeln f{\"u}r den Baubetrieb}, booktitle = {Zahlentafeln f{\"u}r den Baubetrieb}, edition = {9., {\"u}berarb. und aktual. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-02838-1 (Online)}, doi = {10.1007/978-3-658-02838-1_10}, pages = {1165 -- 1246}, year = {2016}, abstract = {Die L{\"o}sung den Baugrund betreffender Fragestellungen beginnen i. d. R. mit der Durchf{\"u}hrung von Baugrunderkundungen, um alle notwendigen Parameter zu erhalten, die f{\"u}r die Planung und Durchf{\"u}hrung von Bauvorhaben notwendig sind. Im Folgenden werden die wichtigsten Erkundungen in Abh{\"a}ngigkeit der erforderlichen G{\"u}teklasse der Proben beschrieben und vorgestellt.}, language = {de} } @incollection{Lemke2016, author = {Lemke, J{\"o}rg}, title = {Unfallverh{\"u}tung, Arbeits- und Gesundheitsschutz}, series = {Zahlentafeln f{\"u}r den Baubetrieb}, booktitle = {Zahlentafeln f{\"u}r den Baubetrieb}, edition = {9., {\"u}berarb. und aktual. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-02838-1 (Online)}, doi = {10.1007/978-3-658-02838-1_15}, pages = {1599 -- 1638}, year = {2016}, abstract = {Neben dem durch Unf{\"a}lle und Krankheiten entstehenden menschlichen Leids und der daraus resultierenden moralischen Verpflichtung, sich und seine Mitmenschen vor Schaden zu bewahren, ist der Arbeits- und Gesundheitsschutz auch ein Gebot wirtschaftlichen Handelns, da Arbeitsunf{\"a}lle und Berufskrankheiten Ausfallzeiten und Kosten verursachen. So geh{\"o}ren Arbeits- und Gesundheitsschutz zu den wichtigen Aufgaben eines Unternehmens.}, language = {de} } @incollection{BorchertRothe2016, author = {Borchert, J{\"o}rg and Rothe, Sebastian}, title = {Energiemanagement und Versorgung von Chemieparks - Ein Ansatz zur wertsch{\"o}pfungsgetriebenen Risikosteuerung}, series = {Chemiestandorte : Markt, Herausforderungen und Gesch{\"a}ftsmodelle}, booktitle = {Chemiestandorte : Markt, Herausforderungen und Gesch{\"a}ftsmodelle}, editor = {Suntrop, Carsten}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {978-3-527-33441-4}, pages = {193 -- 210}, year = {2016}, language = {de} } @incollection{EversFleischhakerPalffyetal.2010, author = {Evers, J{\"o}rg and Fleischhaker, Robert and P{\´a}lffy, A. and Keitel, C.}, title = {Light propagation : From atomic to nuclear quantum optics}, series = {Modern optics and photonics: atoms and structured media}, booktitle = {Modern optics and photonics: atoms and structured media}, publisher = {World Scientific Publishing Co.}, isbn = {978-981431327-8}, doi = {10.1142/9789814313278_0001}, pages = {3 -- 15}, year = {2010}, language = {en} } @incollection{Winkler2016, author = {Winkler, Norbert}, title = {Vermessung}, series = {Zahlentafeln f{\"u}r den Baubetrieb}, booktitle = {Zahlentafeln f{\"u}r den Baubetrieb}, edition = {9., {\"u}berarb. und aktual. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-02838-1 (Online)}, doi = {10.1007/978-3-658-02838-1_3}, pages = {159 -- 177}, year = {2016}, language = {de} } @incollection{Schloesser2016, author = {Schl{\"o}sser, Karl Helmut}, title = {Bauwirtschaft und Baurecht}, series = {Zahlentafeln f{\"u}r den Baubetrieb}, booktitle = {Zahlentafeln f{\"u}r den Baubetrieb}, edition = {9., {\"u}berarb. und aktual. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-02838-1 (Online)}, doi = {10.1007/978-3-658-02838-1_4}, pages = {179 -- 421}, year = {2016}, abstract = {Die Leistungen der Bauwirtschaft und deren wirtschaftliche Bedeutung in Deutschland werden anhand einer Vielzahl statistischer Daten verdeutlicht. Die im Vergleich zu anderen Wirtschaftsbereichen auftretenden branchenspezifischen Besonderheiten der Bauwirtschaft werden anhand von verschiedenen Kriterien herausgearbeitet. Das Zusammenspiel der einzelnen Akteure des Sektors und die dabei sich ergebenden bzw. zu beachtenden Rechts- und Vertragsgrundlagen werden dargestellt. Aufgrund der meist erheblichen H{\"o}he des eingesetzten Kapitals aufseiten der Auftraggeber, aber auch seitens der Bauunternehmen w{\"a}hrend der Bauausf{\"u}hrung sowie der besonderen Verantwortung der Beratenden Ingenieure werden auch notwendige Formen der Risikoabsicherungen und der in der Branche {\"u}blichen und teilweise vorgeschriebenen Versicherungsm{\"o}glichkeiten angesprochen. Intensive Beachtung finden auch die Auswirkungen des {\"O}ffentlichen Baurechts (Baugesetzbuch, Bauordnung NRW, Baunutzungsverordnung) auf Planung, Bau und Betrieb baulicher Anlagen und der dabei verwendeten Bauprodukte.}, language = {de} } @incollection{Schloesser2016, author = {Schl{\"o}sser, Karl Helmut}, title = {Baukosten und Finanzierung}, series = {Zahlentafeln f{\"u}r den Baubetrieb}, booktitle = {Zahlentafeln f{\"u}r den Baubetrieb}, edition = {9., {\"u}berarb. und aktual. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-02838-1 (Online)}, doi = {10.1007/978-3-658-02838-1_5}, pages = {423 -- 634}, year = {2016}, language = {de} } @incollection{Schloesser2016, author = {Schl{\"o}sser, Karl Helmut}, title = {Leistungsbeschreibung und Bauvertrag}, series = {Zahlentafeln f{\"u}r den Baubetrieb}, booktitle = {Zahlentafeln f{\"u}r den Baubetrieb}, edition = {9., {\"u}berarb. und aktual. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-02838-1 (Online)}, doi = {10.1007/978-3-658-02838-1_6}, pages = {635 -- 961}, year = {2016}, abstract = {Das Gesetz gegen Wettbewerbsbeschr{\"a}nkungen bildet die Grundlage f{\"u}r die Verordnung {\"u}ber die Vergabe {\"o}ffentlicher Auftr{\"a}ge, aus der sich die Vergabe- und Vertragsordnungen f{\"u}r Freiberufliche Leistungen (VOF), f{\"u}r Lieferungen und Leistungen (VOL) und f{\"u}r Bauleistungen (VOB) ableiten. Die dabei in Frage kommenden Vergabeverfahren und die einzelnen Schwellenwerte gem{\"a}ß EU-Recht werden detailliert aufbereitet und im Zusammenhang dargestellt. Die f{\"u}r die Ausgestaltung von Bauvertr{\"a}gen notwendigen Grundlagen des Werkvertragsrecht nach BGB sowie die branchenspezifischen Allgemeinen Gesch{\"a}ftsbedingungen in Form der Vertragsordnung f{\"u}r Bauleistungen (VOB) mit ihren Zus{\"a}tzlichen und Besonderen Vertragsbedingungen werden intensiv aufbereitet. Das Zustandekommen eines Bauvertrages ergibt sich dann aus der notwendigen Leistungsbeschreibung mit einem Leistungsverzeichnis und verschiedenen Positionen oder in Form einer Funktionalen Leistungsbeschreibung (Beschreibung mit Leistungsprogramm). Das Auslandsgesch{\"a}ft der Baubranche (Bauausf{\"u}hrende Unternehmen sowie Beratende Ingenieure und Consultants) wird von den jeweils vorliegenden Internationalen Wettbewerbsbedingungen bestimmt, deren Zusammenh{\"a}nge anhand umfangreicher statistischer Daten und anhand von Beispielen dargestellt werden.}, language = {de} } @incollection{WolfKapelyukhScheeretal.2015, author = {Wolf, C. Roland and Kapelyukh, Yury and Scheer, Nico and Henderson, Colin J.}, title = {Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs}, editor = {Wilson, Alan G. E.}, publisher = {RSC Publ.}, address = {Cambridge}, isbn = {978-1-78262-778-4}, doi = {10.1039/9781782622376-00152}, pages = {152 -- 176}, year = {2015}, abstract = {The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.}, language = {en} }