@article{ScheerWolf2014,
  author    = {Scheer, Nico and Wolf, C. Roland},
  title     = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications},
  series = {Xenobiotica},
  volume    = {44},
  journal   = {Xenobiotica},
  number    = {2},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {1366-5928},
  doi       = {10.3109/00498254.2013.815831},
  pages     = {96 -- 108},
  year      = {2014},
  abstract  = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.},
  language  = {en}
}
@article{ScheerWolf2013,
  author    = {Scheer, Nico and Wolf, C. Roland},
  title     = {Xenobiotic receptor humanized mice and their utility},
  series = {Drug Metabolism Reviews},
  journal   = {Drug Metabolism Reviews},
  number    = {1},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1097-9883},
  doi       = {10.3109/03602532.2012.738687},
  pages     = {110 -- 121},
  year      = {2013},
  language  = {en}
}
@article{HendersonScheerWolf2009,
  author    = {Henderson, Colin J. and Scheer, Nico and Wolf, C. Roland},
  title     = {Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man},
  series = {Expert Review of Clinical Pharmacology},
  volume    = {2},
  journal   = {Expert Review of Clinical Pharmacology},
  number    = {2},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1751-2441},
  doi       = {10.1586/17512433.2.2.105},
  pages     = {105 -- 109},
  year      = {2009},
  language  = {en}
}
@article{StanleyHorsburghRossetal.2009,
  author    = {Stanley, Lesley A. and Horsburgh, Brian C. and Ross, Jillian and Scheer, Nico and Wolf, C. Roland},
  title     = {Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior},
  series = {Drug Metabolism Reviews},
  volume    = {41},
  journal   = {Drug Metabolism Reviews},
  number    = {1},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1097-9883},
  doi       = {10.1080/03602530802605040},
  pages     = {27 -- 65},
  year      = {2009},
  language  = {en}
}
@article{StanleyHorsburghRossetal.2006,
  author    = {Stanley, Lesley A. and Horsburgh, Brian C. and Ross, Jillian and Scheer, Nico and Wolf, C. Roland},
  title     = {Nuclear Receptors which play a pivotal role in drug disposition and chemical toxicity},
  series = {Drug Metabolism Reviews},
  volume    = {38},
  journal   = {Drug Metabolism Reviews},
  number    = {3},
  issn      = {1097-9883},
  doi       = {10.1080/03602530600786232},
  pages     = {515 -- 597},
  year      = {2006},
  language  = {en}
}
@article{EngelBayerHoltmannetal.2019,
  author    = {Engel, Mareike and Bayer, Hendrik and Holtmann, Dirk and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Flavin secretion of Clostridium acetobutylicum in a bioelectrochemical system - Is an iron limitation involved?},
  series = {Bioelectrochemistry},
  journal   = {Bioelectrochemistry},
  number    = {In Press, Accepted Manuscript},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1567-5394},
  doi       = {10.1016/j.bioelechem.2019.05.014},
  year      = {2019},
  language  = {en}
}
@article{ScheerRossRodeetal.2008,
  author    = {Scheer, Nico and Ross, Jillian and Rode, Anja and Zevnik, Branko and Niehaves, Sandra and Faust, Nicole and Wolf, C. Roland},
  title     = {A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response},
  series = {Journal of Clinical Investigation},
  volume    = {118},
  journal   = {Journal of Clinical Investigation},
  number    = {9},
  issn      = {1558-8238},
  doi       = {https://doi.org/10.1172/JCI35483},
  pages     = {3228 -- 3239},
  year      = {2008},
  language  = {en}
}
@article{ScheerKapelyukhMcEwanetal.2012,
  author    = {Scheer, Nico and Kapelyukh, Yury and McEwan, Jillian and Beuger, Vincent and Stanley, Lesley A. and Rode, Anja and Wolf, C. Roland},
  title     = {Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines},
  series = {Molecular Pharmacology},
  volume    = {81},
  journal   = {Molecular Pharmacology},
  number    = {1},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-0111},
  doi       = {10.1124/mol.111.075192},
  pages     = {63 -- 72},
  year      = {2012},
  abstract  = {The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25\% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.},
  language  = {en}
}
@article{ReugelsBoggettiScheeretal.2006,
  author    = {Reugels, Alexander M. and Boggetti, Barbara and Scheer, Nico and Campos-Ortega, Jos{\´e} A.},
  title     = {Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio},
  series = {Developmental Dynamics},
  volume    = {235},
  journal   = {Developmental Dynamics},
  number    = {4},
  issn      = {1097-0177},
  doi       = {10.1002/dvdy.20699},
  pages     = {934 -- 948},
  year      = {2006},
  language  = {en}
}
@article{HansScheerRiedletal.2004,
  author    = {Hans, Stefan and Scheer, Nico and Riedl, Iris and Weiz{\"a}cker, Elisabeth von and Blader, Patrick and Campos-Ortega, Jos{\´e} A.},
  title     = {her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling},
  series = {Development},
  volume    = {131},
  journal   = {Development},
  number    = {12},
  issn      = {1477-9129},
  doi       = {10.1242/dev.01167},
  pages     = {2957 -- 2969},
  year      = {2004},
  language  = {en}
}