@article{BayerTemizArtmannDigeletal.2020, author = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen}, title = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model}, series = {Cellular Physiology and Biochemistry}, volume = {54}, journal = {Cellular Physiology and Biochemistry}, publisher = {Cell Physiol Biochem Press}, address = {D{\"u}sseldorf}, issn = {1421-9778}, doi = {10.33594/000000225}, pages = {371 -- 383}, year = {2020}, abstract = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.}, language = {en} } @article{BeckerWallangArtmannetal.2008, author = {Becker, C. and Wallang, C. and Artmann, Gerhard and Jakse, G.}, title = {Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis}, series = {International Journal of Artificial Organs, The}, volume = {31}, journal = {International Journal of Artificial Organs, The}, number = {7}, issn = {0391-3988}, pages = {583 -- 583}, year = {2008}, language = {en} } @article{Schmitz2004, author = {Schmitz, G{\"u}nter}, title = {Mechatronic Systems Simulation as an obligatory module for Mechatronic Master Students}, series = {Mechatronics \& Robotics 2004 : Aachen, Germany, September 13 - 15, 2004 / [IEEE Industrial Electronics Society ...] P. Drews (ed.)}, journal = {Mechatronics \& Robotics 2004 : Aachen, Germany, September 13 - 15, 2004 / [IEEE Industrial Electronics Society ...] P. Drews (ed.)}, publisher = {Eysoldt}, address = {Aachen}, isbn = {3-938153-50-X}, pages = {1278}, year = {2004}, language = {en} } @article{EnningJenayehMuelleretal.1998, author = {Enning, Manfred and Jenayeh, I. and M{\"u}ller, C. and Kositza, N.}, title = {Mechatronics in automating shunting processes in marshalling yards / Jenayeh, I. ; M{\"u}ller, C.; Kositza, N. ; Enning, M. ; Rake, H.}, series = {Mechatronics '98 : proceedings of the 6th UK Mechatronics Forum International Conference, Sk{\"o}vde, Sweden, 9-11 September 1998}, journal = {Mechatronics '98 : proceedings of the 6th UK Mechatronics Forum International Conference, Sk{\"o}vde, Sweden, 9-11 September 1998}, publisher = {Pergamon}, address = {Amsterdam}, isbn = {0-08-043339-1}, pages = {xxi, 918 S. : graph. Darst.}, year = {1998}, language = {en} } @article{HartungReyMathieuetal.2004, author = {Hartung, Frank and Rey, J. and Mathieu, B. and Lozano, D.}, title = {Media aware overlay routing in Ambient Networks / Rey, J. ; Mathieu, B. ; Lozano, D. ; Herborn, S. ; Ahmed, K. ; Schmid, S. ; Goebbels, S. ; Hartung, F. ; Kampmann, M.}, series = {16th IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, 2005. PIMRC 2005. Date:11-14 Sept. 2005 ; Vol. 2}, journal = {16th IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, 2005. PIMRC 2005. Date:11-14 Sept. 2005 ; Vol. 2}, pages = {952 -- 957}, year = {2004}, language = {en} } @article{HartungKampmann2007, author = {Hartung, Frank and Kampmann, Markus}, title = {Media Delivery Based on Service Aware Transport Overlay Networks / Kampmann, Markus ; Hartung, Frank}, series = {KIVS 2007 : Kommunikation in verteilten Systemen : 15. ITG-GI-Fachtagung vom 26. Februar bis 2. M{\"a}rz 2007 in Bern, Schweiz ; Industriebeitr{\"a}ge, Kurzbeitr{\"a}ge und Workshops / T. Braun ... (Hrsg.)}, journal = {KIVS 2007 : Kommunikation in verteilten Systemen : 15. ITG-GI-Fachtagung vom 26. Februar bis 2. M{\"a}rz 2007 in Bern, Schweiz ; Industriebeitr{\"a}ge, Kurzbeitr{\"a}ge und Workshops / T. Braun ... (Hrsg.)}, isbn = {978-3-8007-2980-7}, pages = {9 -- 10}, year = {2007}, language = {en} } @article{WerkhausenWillwacherAlbracht2021, author = {Werkhausen, Amelie and Willwacher, Steffen and Albracht, Kirsten}, title = {Medial gastrocnemius muscle fascicles shorten throughout stance during sprint acceleration}, series = {Scandinavian Journal of Medicine \& Science in Sports}, volume = {31}, journal = {Scandinavian Journal of Medicine \& Science in Sports}, number = {7}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {0905-7188 (Druckausgabe)}, doi = {10.1111/sms.13956}, pages = {1471 -- 1480}, year = {2021}, abstract = {The compliant nature of distal limb muscle-tendon units is traditionally considered suboptimal in explosive movements when positive joint work is required. However, during accelerative running, ankle joint net mechanical work is positive. Therefore, this study aims to investigate how plantar flexor muscle-tendon behavior is modulated during fast accelerations. Eleven female sprinters performed maximum sprint accelerations from starting blocks, while gastrocnemius muscle fascicle lengths were estimated using ultrasonography. We combined motion analysis and ground reaction force measurements to assess lower limb joint kinematics and kinetics, and to estimate gastrocnemius muscle-tendon unit length during the first two acceleration steps. Outcome variables were resampled to the stance phase and averaged across three to five trials. Relevant scalars were extracted and analyzed using one-sample and two-sample t-tests, and vector trajectories were compared using statistical parametric mapping. We found that an uncoupling of muscle fascicle behavior from muscle-tendon unit behavior is effectively used to produce net positive mechanical work at the joint during maximum sprint acceleration. Muscle fascicles shortened throughout the first and second steps, while shortening occurred earlier during the first step, where negative joint work was lower compared with the second step. Elastic strain energy may be stored during dorsiflexion after touchdown since fascicles did not lengthen at the same time to dissipate energy. Thus, net positive work generation is accommodated by the reuse of elastic strain energy along with positive gastrocnemius fascicle work. Our results show a mechanism of how muscles with high in-series compliance can contribute to net positive joint work.}, language = {en} } @article{MartinGonzalezKotliarRiosMartinezetal.2014, author = {Martin-Gonzalez, Anabel and Kotliar, Konstantin and Rios-Martinez, Jorge and Lanzl, Ines and Navab, Nassir}, title = {Mediated-reality magnification for macular degeneration rehabilitation}, series = {Journal of Modern Optics}, volume = {61}, journal = {Journal of Modern Optics}, number = {17}, publisher = {Taylor \& Francis}, address = {London}, issn = {1362-3044}, doi = {10.1080/09500340.2014.936110}, pages = {1400 -- 1408}, year = {2014}, language = {en} } @article{InagakiSleddensLinkelsWassenaaretal.2011, author = {Inagaki, Akiko and Sleddens-Linkels, Esther and Wassenaar, Evelyne and Ooms, Marja and Cappellen, Wiggert A. van and Hoeijmakers, Jan H. J. and Seibler, Jost and Vogt, Thomas F. and Shin, Myung K. and Grootegoed, J. Anton and Baarends, Willy M.}, title = {Meiotic functions of RAD18}, series = {Journal of Cell Science}, volume = {124}, journal = {Journal of Cell Science}, number = {16}, publisher = {Company of Biologists Limited}, address = {Cambridge}, issn = {1477-9137}, doi = {10.1242/jcs.081968}, pages = {2837 -- 2850}, year = {2011}, language = {en} } @article{KernZischank1988, author = {Kern, Alexander and Zischank, Wolfgang J.}, title = {Melting effects on metal sheets and air termination wires caused by direct lightning strikes}, series = {Conference proceedings : Graz, {\"O}sterreich, 25. - 29. April 1988 / Gesamtorganisation: {\"O}sterr. Verb. f{\"u}r Elektrotechnik ({\"O}VE), Fachausschuß Blitzschutz ... [Red.: G. Diendorfer ...]}, journal = {Conference proceedings : Graz, {\"O}sterreich, 25. - 29. April 1988 / Gesamtorganisation: {\"O}sterr. Verb. f{\"u}r Elektrotechnik ({\"O}VE), Fachausschuß Blitzschutz ... [Red.: G. Diendorfer ...]}, publisher = {Eigenverl. des {\"O}VE}, address = {Wien}, isbn = {3-85133-001-3}, year = {1988}, language = {en} }