@article{StaatTrenzLohmannetal.2012,
  author    = {Staat, Manfred and Trenz, Eva and Lohmann, Philipp and Frotscher, Ralf and Klinge, Uwe and Tabaza, Ruth and Kirschner-Hermanns, Ruth},
  title     = {New measurements to compare soft tissue anchoring systems in pelvic floor surgery},
  series = {Journal of Biomedical Materials Research Part B: Applied Biomaterials},
  volume    = {100B},
  journal   = {Journal of Biomedical Materials Research Part B: Applied Biomaterials},
  number    = {4},
  publisher = {Wiley},
  address   = {Hoboken, NJ},
  issn      = {1552-4981},
  doi       = {10.1002/jbm.b.32654},
  pages     = {924 -- 933},
  year      = {2012},
  abstract  = {Suburethral slings as well as different meshes are widely used treating stress urinary incontinence and prolaps in women. With the development of MiniSlings and special meshes using less alloplastic material anchorage systems become more important to keep devices in place and to put some tension especially on the MiniSlings. To date, there are many different systems of MiniSlings of different companies on the market which differ in the structure of the used meshes and anchors. A new objective measurement method to compare different properties of MiniSling systems (mesh and anchor) is presented in this article. Ballistic gelatine acts as soft tissue surrogate. Significant differences in parameters like pull-out strength of anchors or shrinkage of meshes under loading conditions have been determined. The form and size of the anchors as well as the structural stability of the meshes are decisive for a proper integration. The tested anchorings sytems showed markedly different mechanical function at their respective load bearing capacity. As the stable fixation of the device in tissue is a prerequisite for a permanet reinforcement, the proposed test system permits further optimisation of anchor and mesh devices to improve the success of the surgical treatment},
  language  = {en}
}
@article{BhattaraiStaat2018,
  author    = {Bhattarai, Aroj and Staat, Manfred},
  title     = {Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions},
  series = {Computational and Mathematical Methods in Medicine},
  volume    = {2018},
  journal   = {Computational and Mathematical Methods in Medicine},
  number    = {Article ID 9518076},
  publisher = {Hindawi},
  address   = {New York, NY},
  issn      = {1748-6718},
  doi       = {10.1155/2018/9518076},
  pages     = {1 -- 16},
  year      = {2018},
  abstract  = {After menopause, decreased levels of estrogen and progesterone remodel the collagen of the soft tissues thereby reducing their stiffness. Stress urinary incontinence is associated with involuntary urine leakage due to pathological movement of the pelvic organs resulting from lax suspension system, fasciae, and ligaments. This study compares the changes in the orientation and position of the female pelvic organs due to weakened fasciae, ligaments, and their combined laxity. A mixture theory weighted by respective volume fraction of elastin-collagen fibre compound (5\%), adipose tissue (85\%), and smooth muscle (5\%) is adopted to characterize the mechanical behaviour of the fascia. The load carrying response (other than the functional response to the pelvic organs) of each fascia component, pelvic organs, muscles, and ligaments are assumed to be isotropic, hyperelastic, and incompressible. Finite element simulations are conducted during Valsalva manoeuvre with weakened tissues modelled by reduced tissue stiffness. A significant dislocation of the urethrovesical junction is observed due to weakness of the fascia (13.89 mm) compared to the ligaments (5.47 mm). The dynamics of the pelvic floor observed in this study during Valsalva manoeuvre is associated with urethral-bladder hypermobility, greater levator plate angulation, and positive Q-tip test which are observed in incontinent females.},
  language  = {en}
}
@article{HorbachDuongStaat2017,
  author    = {Horbach, Andreas and Duong, Minh Tuan and Staat, Manfred},
  title     = {Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement},
  series = {Journal of the mechanical behavior of biomedical materials},
  volume    = {74},
  journal   = {Journal of the mechanical behavior of biomedical materials},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1751-6161},
  doi       = {10.1016/j.jmbbm.2017.06.012},
  pages     = {400 -- 410},
  year      = {2017},
  language  = {en}
}
@article{JungStaat2019,
  author    = {Jung, Alexander and Staat, Manfred},
  title     = {Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue},
  series = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik},
  volume    = {42},
  journal   = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik},
  number    = {4},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1522-2608},
  doi       = {10.1002/gamm.201900002},
  pages     = {11 Seiten},
  year      = {2019},
  language  = {en}
}
@article{GossmannFrotscherLinderetal.2016,
  author    = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells},
  series = {Cellular physiology and biochemistry},
  volume    = {38},
  journal   = {Cellular physiology and biochemistry},
  number    = {3},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1421-9778 (Online)},
  doi       = {10.1159/000443124},
  pages     = {1182 -- 1198},
  year      = {2016},
  abstract  = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.},
  language  = {en}
}
@article{Staat2005,
  author    = {Staat, Manfred},
  title     = {Local and global collapse pressure of longitudinally flawed pipes and cylindrical vessels},
  series = {International Journal of Pressure Vessels and Piping. 82 (2005), H. 3},
  journal   = {International Journal of Pressure Vessels and Piping. 82 (2005), H. 3},
  isbn      = {0308-0161},
  pages     = {217 -- 225},
  year      = {2005},
  language  = {en}
}
@article{StaatTranKreissig2008,
  author    = {Staat, Manfred and Tran, Thanh Ngoc and Kreißig, R.},
  title     = {Load bearing capacity of thin shell structures made of elastoplastic material by direct methods},
  series = {Technische Mechanik. 28 (2008), H. 3-4},
  journal   = {Technische Mechanik. 28 (2008), H. 3-4},
  pages     = {299 -- 309},
  year      = {2008},
  language  = {en}
}
@article{StaatHeitzerHicken1998,
  author    = {Staat, Manfred and Heitzer, M. and Hicken, E.F.},
  title     = {LISA, ein europ{\"a}isches Projekt zur direkten Berechnung der Tragf{\"a}higkeit duktiler Strukturen.},
  year      = {1998},
  language  = {de}
}
@article{StaatVu2006,
  author    = {Staat, Manfred and Vu, Khoi Duc},
  title     = {Limit loads of circumferentially flawed pipes and cylindrical vessels under internal pressure},
  series = {International Journal of Pressure Vessels and Piping. 83 (2006), H. 3},
  journal   = {International Journal of Pressure Vessels and Piping. 83 (2006), H. 3},
  isbn      = {0308-0161},
  pages     = {188 -- 196},
  year      = {2006},
  language  = {en}
}
@article{StaatHeitzer2002,
  author    = {Staat, Manfred and Heitzer, M.},
  title     = {Limit and Shakedown Analysis with Uncertain Data},
  series = {Stochastic optimization techniques : numerical methods and technical applications / Marti, K. [ed]},
  journal   = {Stochastic optimization techniques : numerical methods and technical applications / Marti, K. [ed]},
  publisher = {Springer},
  address   = {Heidelberg},
  isbn      = {3-540-42889-5},
  pages     = {241 -- 254},
  year      = {2002},
  language  = {en}
}