@article{SchwertnerBerndtGielenetal.1975,
  author    = {Schwertner, Eberhard and Berndt, Heinz and Gielen, Hans-G{\"u}nter and Zahn, Helmut},
  title     = {Peptide 96 : Synthese einiger [2-(p-Biphenylyl)isopropyloxycarbonyl]-Aminos{\"a}urederivate},
  series = {Justus Liebigs Annalen der Chemie},
  volume    = {75},
  journal   = {Justus Liebigs Annalen der Chemie},
  number    = {3},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1099-0690},
  doi       = {10.1002/jlac.197519750318},
  pages     = {581 -- 585},
  year      = {1975},
  abstract  = {Die Darstellung der N-[2-(p-Biphenylyl)isopropyloxycarbonyl]-Derivate (Bpoc-Derivate) des Cysteins unter Verwendung der Thiolschutzgruppen Tetrahydropyranyl (Thp) f{\"u}r 1, Diphenylmethyl (Dpm) f{\"u}r 2, Trityl (Trt) f{\"u}r 3 und S-tert.-Butyl (SBut) f{\"u}r 4 sowie die Synthese von aktivierten Estern der Bpoc-Derivate des Glycins (5), Isoleucins (6) und Prolins (7) werden beschrieben. An einem Beispiel wird die M{\"o}glichkeit aufgezeigt, die Bpoc-Gruppe {\"u}ber das Bpoc-Azid nachtr{\"a}glich in den Peptidverband einzuf{\"u}hren.},
  language  = {de}
}
@article{WolfBerndtBrandenburg1979,
  author    = {Wolf, G{\"u}nter and Berndt, Heinz and Brandenburg, Dietrich},
  title     = {Synthese der [LysA13] Rinderinsulin-A-Kette in der Form [Lys(Tfa)A13]A(SO3H)4 und NαA1-Msc-[LysA13]A(SO3H)4 unter Verwendung des S-tert-Butylmercapto-Restes als Thiolschutzgruppe},
  series = {Hoppe-Seyler's Zeitschrift f{\"u}r physiologische Chemie},
  volume    = {360},
  journal   = {Hoppe-Seyler's Zeitschrift f{\"u}r physiologische Chemie},
  number    = {2},
  issn      = {1437-4315},
  doi       = {10.1515/bchm2.1979.360.2.1569},
  pages     = {1569 -- 1578},
  year      = {1979},
  language  = {de}
}
@article{HacklBuessKammerlohretal.2021,
  author    = {Hackl, Michael and Buess, Eduard and Kammerlohr, Sandra and Nacov, Julia and Staat, Manfred and Leschinger, Tim and M{\"u}ller, Lars P. and Wegmann, Kilian},
  title     = {A "comma sign"-directed subscapularis repair in anterosuperior rotator cuff tears yields biomechanical advantages in a cadaveric model},
  series = {The american journal of sports medicine},
  volume    = {49},
  journal   = {The american journal of sports medicine},
  number    = {12},
  publisher = {Sage},
  address   = {London},
  issn      = {1552-3365},
  doi       = {10.1177/03635465211031506},
  pages     = {3212 -- 3217},
  year      = {2021},
  abstract  = {Background: Additional stabilization of the "comma sign" in anterosuperior rotator cuff repair has been proposed to provide biomechanical benefits regarding stability of the repair. Purpose: This in vitro investigation aimed to investigate the influence of a comma sign-directed reconstruction technique for anterosuperior rotator cuff tears on the primary stability of the subscapularis tendon repair. Study Design: Controlled laboratory study. Methods: A total of 18 fresh-frozen cadaveric shoulders were used in this study. Anterosuperior rotator cuff tears (complete full-thickness tear of the supraspinatus and subscapularis tendons) were created, and supraspinatus repair was performed with a standard suture bridge technique. The subscapularis was repaired with either a (1) single-row or (2) comma sign technique. A high-resolution 3D camera system was used to analyze 3-mm and 5-mm gap formation at the subscapularis tendon-bone interface upon incremental cyclic loading. Moreover, the ultimate failure load of the repair was recorded. A Mann-Whitney test was used to assess significant differences between the 2 groups. Results: The comma sign repair withstood significantly more loading cycles than the single-row repair until 3-mm and 5-mm gap formation occurred (P≤ .047). The ultimate failure load did not reveal any significant differences when the 2 techniques were compared (P = .596). Conclusion: The results of this study show that additional stabilization of the comma sign enhanced the primary stability of subscapularis tendon repair in anterosuperior rotator cuff tears. Although this stabilization did not seem to influence the ultimate failure load, it effectively decreased the micromotion at the tendon-bone interface during cyclic loading. Clinical Relevance: The proposed technique for stabilization of the comma sign has shown superior biomechanical properties in comparison with a single-row repair and might thus improve tendon healing. Further clinical research will be necessary to determine its influence on the functional outcome.},
  language  = {en}
}
@article{FrotscherMuanghongDursunetal.2016,
  author    = {Frotscher, Ralf and Muanghong, Danita and Dursun, G{\"o}zde and Goßmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Staat, Manfred},
  title     = {Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue},
  series = {Journal of Biomechanics},
  volume    = {49},
  journal   = {Journal of Biomechanics},
  number    = {12},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0021-9290 (Print)},
  doi       = {10.1016/j.jbiomech.2016.01.039},
  pages     = {2428 -- 2435},
  year      = {2016},
  abstract  = {We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.},
  language  = {en}
}
@article{OjovanSteinmetz2022,
  author    = {Ojovan, Michael I. and Steinmetz, Hans-J{\"u}rgen},
  title     = {Approaches to Disposal of Nuclear Waste},
  series = {Energies},
  volume    = {15},
  journal   = {Energies},
  number    = {20},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1996-1073},
  doi       = {10.3390/en15207804},
  pages     = {Artikel 7804},
  year      = {2022},
  abstract  = {We present a concise mini overview on the approaches to the disposal of nuclear waste currently used or deployed. The disposal of nuclear waste is the end point of nuclear waste management (NWM) activities and is the emplacement of waste in an appropriate facility without the intention to retrieve it. The IAEA has developed an internationally accepted classification scheme based on the end points of NWM, which is used as guidance. Retention times needed for safe isolation of waste radionuclides are estimated based on the radiotoxicity of nuclear waste. Disposal facilities usually rely on a multi-barrier defence system to isolate the waste from the biosphere, which comprises the natural geological barrier and the engineered barrier system. Disposal facilities could be of a trench type, vaults, tunnels, shafts, boreholes, or mined repositories. A graded approach relates the depth of the disposal facilities' location with the level of hazard. Disposal practices demonstrate the reliability of nuclear waste disposal with minimal expected impacts on the environment and humans.},
  language  = {en}
}
@article{LeschingerBirgelHackletal.2019,
  author    = {Leschinger, Tim and Birgel, Stefan and Hackl, Michael and Staat, Manfred and M{\"u}ller, Lars Peter and Wegmann, Kilian},
  title     = {A musculoskeletal shoulder simulation of moment arms and joint reaction forces after medialization of the supraspinatus footprint in rotator cuff repair},
  series = {Computer Methods in Biomechanics and Biomedical Engineering},
  journal   = {Computer Methods in Biomechanics and Biomedical Engineering},
  number    = {Early view},
  publisher = {Taylor \& Francis},
  address   = {London},
  doi       = {10.1080/10255842.2019.1572749},
  year      = {2019},
  language  = {en}
}
@article{DietzelWeberPorschenetal.1976,
  author    = {Dietzel, F. and Weber, Hans-Joachim and Porschen, W. and Feinendegen, L. E.},
  title     = {Zur W{\"a}rmeempfindlichkeit von oxischen und hypoxischen Zellen in einem Tumor},
  series = {Naturwissenschaften},
  volume    = {63},
  journal   = {Naturwissenschaften},
  number    = {12},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {0028-1042},
  doi       = {10.1007/BF00622808},
  pages     = {585 -- 586},
  year      = {1976},
  language  = {de}
}
@article{Timme2023,
  author    = {Timme, Michael},
  title     = {Die Erbringung einer Leistung in der irrigen Vorstellung einer Bestellung (Zu BGH, MDR 2023, 1439)},
  series = {Monatsschrift f{\"u}r Deutsches Recht},
  volume    = {77},
  journal   = {Monatsschrift f{\"u}r Deutsches Recht},
  number    = {24},
  publisher = {Verlag Dr. Otto Schmidt},
  address   = {K{\"o}ln},
  issn      = {2194-4202 (online)},
  doi       = {10.9785/mdtr-2023-772402},
  pages     = {R293 -- R296},
  year      = {2023},
  language  = {de}
}
@article{HueningHeuermannWacheetal.2018,
  author    = {H{\"u}ning, Felix and Heuermann, Holger and Wache, Franz-Josef and Jajo, Rami Audisho},
  title     = {A new wireless sensor interface using dual-mode radio},
  series = {Journal of Sensors and Sensor Systems : JSSS},
  volume    = {Volume 7},
  journal   = {Journal of Sensors and Sensor Systems : JSSS},
  number    = {2},
  publisher = {Copernicus Publ.},
  address   = {G{\"o}ttingen},
  doi       = {10.5194/jsss-7-507-2018},
  pages     = {507 -- 515},
  year      = {2018},
  abstract  = {The integration of sensors is one of the major tasks in embedded, control and "internet of things" (IoT) applications. For the integration mainly digital interfaces are used, starting from rather simple pulse-width modulation (PWM) interface to more complex interfaces like CAN (Controller Area Network). Even though these interfaces are tethered by definition, a wireless realization is highly welcome in many applications to reduce cable and connector cost, increase the flexibility and realize new emerging applications like wireless control systems. Currently used wireless solutions like Bluetooth, WirelessHART or IO-Link Wireless use dedicated communication standards and corresponding higher protocol layers to realize the wireless communication. Due to the complexity of the communication and the protocol handling, additional latency and jitter are introduced to the data communication that can meet the requirements for many applications. Even though tunnelling of other bus data like CAN data is generally also possible the latency and jitter prevent the tunnelling from being transparent for the bus system. Therefore a new basic technology based on dual-mode radio is used to realize a wireless communication on the physical layer only, enabling a reliable and real-time data transfer. As this system operates on the physical layer it is independent of any higher layers of the OSI (open systems interconnection) model. Hence it can be used for several different communication systems to replace the tethered physical layer. A prototype is developed and tested for real-time wireless PWM, SENT (single-edge nibble transmission) and CAN data transfer with very low latency and jitter.},
  language  = {en}
}
@article{HaegerJolmesOyenetal.2024,
  author    = {Haeger, Gerrit and Jolmes, Tristan and Oyen, Sven and Jaeger, Karl-Erich and Bongaerts, Johannes and Sch{\"o}rken, Ulrich and Siegert, Petra},
  title     = {Novel recombinant aminoacylase from Paraburkholderia monticola capable of N-acyl-amino acid synthesis},
  series = {Applied Microbiology and Biotechnology},
  journal   = {Applied Microbiology and Biotechnology},
  number    = {108},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1432-0614},
  doi       = {10.1007/s00253-023-12868-8},
  pages     = {14 Seiten},
  year      = {2024},
  abstract  = {N-Acyl-amino acids can act as mild biobased surfactants, which are used, e.g., in baby shampoos. However, their chemical synthesis needs acyl chlorides and does not meet sustainability criteria. Thus, the identification of biocatalysts to develop greener synthesis routes is desirable. We describe a novel aminoacylase from Paraburkholderia monticola DSM 100849 (PmAcy) which was identified, cloned, and evaluated for its N-acyl-amino acid synthesis potential. Soluble protein was obtained by expression in lactose autoinduction medium and co-expression of molecular chaperones GroEL/S. Strep-tag affinity purification enriched the enzyme 16-fold and yielded 15 mg pure enzyme from 100 mL of culture. Biochemical characterization revealed that PmAcy possesses beneficial traits for industrial application like high temperature and pH-stability. A heat activation of PmAcy was observed upon incubation at temperatures up to 80 °C. Hydrolytic activity of PmAcy was detected with several N-acyl-amino acids as substrates and exhibited the highest conversion rate of 773 U/mg with N-lauroyl-L-alanine at 75 °C. The enzyme preferred long-chain acyl-amino-acids and displayed hardly any activity with acetyl-amino acids. PmAcy was also capable of N-acyl-amino acid synthesis with good conversion rates. The best synthesis results were obtained with the cationic L-amino acids L-arginine and L-lysine as well as with L-leucine and L-phenylalanine. Exemplarily, L-phenylalanine was acylated with fatty acids of chain lengths from C8 to C18 with conversion rates of up to 75\%. N-lauroyl-L-phenylalanine was purified by precipitation, and the structure of the reaction product was verified by LC-MS and NMR.},
  language  = {en}
}