@article{WagnerWernerMiyamotoetal.2010,
  author    = {Wagner, Torsten and Werner, Frederik and Miyamoto, Ko-ichiro and Ackermann, Hans-Josef and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef},
  title     = {FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces},
  series = {Physica Status Solidi (A)},
  volume    = {207},
  journal   = {Physica Status Solidi (A)},
  number    = {4},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300},
  doi       = {10.1002/pssa.200983320},
  pages     = {844 -- 849},
  year      = {2010},
  abstract  = {The development of new interfaces for (bio-)chemical sensors requires comprehensive analyses and testing. The light-addressable potentiometric sensor (LAPS) can be used as a platform to investigate the sensitivity of a newly developed interface towards (bio-)chemical agents. LAPS measurements are spatially resolved by utilisation of focused light beams to define individual measurement spots. In this work, a new digitally modulated LAPS set-up based on an FPGA design will be introduced to increase the number of measurement spots, to shorten the measurement time and to improve the measurement accuracy.},
  language  = {en}
}
@article{BerretzSkorupaSanderetal.2011,
  author    = {Berretz, Frank and Skorupa, Sascha and Sander, Volker and Belloum, Adam and Bubak, Marian},
  title     = {Actor-Driven Workflow Execution in Distributed Environments},
  series = {Euro-Par 2010 Parallel Processing Workshops : HeteroPAR, HPCC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC ; Ischia, Italy, August 31 - September 3, 2010 ; revised selected papers / Mario R. Guarracino ... (eds.)},
  journal   = {Euro-Par 2010 Parallel Processing Workshops : HeteroPAR, HPCC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC ; Ischia, Italy, August 31 - September 3, 2010 ; revised selected papers / Mario R. Guarracino ... (eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-642-21877-4},
  pages     = {287 -- 294},
  year      = {2011},
  language  = {en}
}
@article{GerhardsSkorupaSanderetal.2011,
  author    = {Gerhards, M. and Skorupa, Sascha and Sander, Volker and Pfeiffer, P. and Belloum, Adam},
  title     = {Towards a security framework for a WS-HumanTask processor},
  series = {7th International Conference on Network and Service Management (CNSM), 2011 Paris},
  journal   = {7th International Conference on Network and Service Management (CNSM), 2011 Paris},
  publisher = {IEEE},
  address   = {New York},
  isbn      = {978-3-901882-44-9},
  pages     = {1 -- 5},
  year      = {2011},
  language  = {en}
}
@article{BernauKnoedlerEmontsetal.2022,
  author    = {Bernau, C. R. and Kn{\"o}dler, Matthias and Emonts, Jessica and J{\"a}pel, Ronald Colin and Buyel, Johannes Felix},
  title     = {The use of predictive models to develop chromatography-based purification processes},
  series = {Frontiers in Bioengineering and Biotechnology},
  journal   = {Frontiers in Bioengineering and Biotechnology},
  number    = {10},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-4185 (online-ressource)},
  doi       = {10.3389/fbioe.2022.1009102},
  pages     = {25 Seiten},
  year      = {2022},
  abstract  = {Chromatography is the workhorse of biopharmaceutical downstream processing because it can selectively enrich a target product while removing impurities from complex feed streams. This is achieved by exploiting differences in molecular properties, such as size, charge and hydrophobicity (alone or in different combinations). Accordingly, many parameters must be tested during process development in order to maximize product purity and recovery, including resin and ligand types, conductivity, pH, gradient profiles, and the sequence of separation operations. The number of possible experimental conditions quickly becomes unmanageable. Although the range of suitable conditions can be narrowed based on experience, the time and cost of the work remain high even when using high-throughput laboratory automation. In contrast, chromatography modeling using inexpensive, parallelized computer hardware can provide expert knowledge, predicting conditions that achieve high purity and efficient recovery. The prediction of suitable conditions in silico reduces the number of empirical tests required and provides in-depth process understanding, which is recommended by regulatory authorities. In this article, we discuss the benefits and specific challenges of chromatography modeling. We describe the experimental characterization of chromatography devices and settings prior to modeling, such as the determination of column porosity. We also consider the challenges that must be overcome when models are set up and calibrated, including the cross-validation and verification of data-driven and hybrid (combined data-driven and mechanistic) models. This review will therefore support researchers intending to establish a chromatography modeling workflow in their laboratory.},
  language  = {en}
}
@article{FredebeulKreinKnoben2010,
  author    = {Fredebeul-Krein, Markus and Knoben, Werner},
  title     = {Long term risk sharing contracts as an approach to establish public-private partnerships for investment into next generation access networks},
  series = {Telecommunications Policy},
  volume    = {34},
  journal   = {Telecommunications Policy},
  number    = {9},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0308-5961},
  doi       = {10.1016/j.telpol.2010.07.011},
  pages     = {528 -- 539},
  year      = {2010},
  abstract  = {This paper develops an investment/pricing model for the deployment of basic broadband networks which, along with other applications, is applicable to public-private partnership projects. In particular, a new investment model is suggested to be used for finance deployment over a longer term by enabling both private and public investors to participate in the roll-out of next generation access (NGA) infrastructure. This so-called "long-term risk sharing concept" has several notable benefits compared with the traditional regulatory approach. Above all, the model enables both private operators and public authorities to share the risk of investing in NGA infrastructure. Thus the model offers a way for public authorities to achieve a timely and countrywide roll-out of NGA networks, including in areas where NGA investment would otherwise not occur.},
  language  = {en}
}
@article{FredebeulKrein2010,
  author    = {Fredebeul-Krein, Markus},
  title     = {Wirtschaftskrise : Staatliche F{\"o}rderung von glasfaserbasierten Breitbandnetzen?},
  series = {Wirtschaftsdienst},
  volume    = {90},
  journal   = {Wirtschaftsdienst},
  number    = {2},
  publisher = {ZBW},
  address   = {Berlin},
  issn      = {0043-6275},
  pages     = {113 -- 117},
  year      = {2010},
  abstract  = {Glasfaserbasierte Breitbandnetze werden in Deutschland auch aufgrund der Wirtschaftskrise nur sehr z{\"o}gerlich ausgebaut. Markus Fredebeul-Krein h{\"a}lt eine staatliche Subventionierung der Breitbandnetze nur bedingt f{\"u}r gerechtfertigt. Private Investoren ben{\"o}tigen jedoch dringend Planungssicherheit durch verl{\"a}ssliche Regulierungsvorschriften.},
  language  = {de}
}
@article{SchlamannYoonMaderwaldetal.2009,
  author    = {Schlamann, M. and Yoon, M.-S. and Maderwald, S. and Pietrzyk, Thomas and Bitz, Andreas and Gerwig, M. and Forsting, M. and Ladd, S. C. and Ladd, M. E. and Kastrup, O.},
  title     = {Auswirkungen der Magnetresonanztomografie auf die Elektrophysiologie des motorischen Kortex: eine Studie mit transkranieller Magnetstimulation},
  series = {R{\"o}Fo - Fortschritte auf dem Giebiet der R{\"o}ntgenstrahlen und der bildgebenden Verfahren},
  volume    = {181},
  journal   = {R{\"o}Fo - Fortschritte auf dem Giebiet der R{\"o}ntgenstrahlen und der bildgebenden Verfahren},
  number    = {3},
  publisher = {Thieme},
  address   = {Stuttgart},
  issn      = {1438-9029},
  doi       = {10.1055/s-0028-1109038},
  pages     = {215 -- 219},
  year      = {2009},
  language  = {de}
}
@article{GerhardsSkorupaSanderetal.2011,
  author    = {Gerhards, M. and Skorupa, Sascha and Sander, Volker and Belloum, Adam and Vesunin, D. and Benabdelkader, A.},
  title     = {HisT/PLIER : A Two-Fold Provenance Approach for Grid-Enabled Scientific Workflows Using WS-VLAM},
  series = {12th IEEE/ACM International Conference on Grid Computing (GRID), 2011},
  journal   = {12th IEEE/ACM International Conference on Grid Computing (GRID), 2011},
  publisher = {IEEE},
  address   = {New York},
  doi       = {10.1109/Grid.2011.39},
  pages     = {224 -- 225},
  year      = {2011},
  language  = {en}
}
@article{FredebeulKrein2010,
  author    = {Fredebeul-Krein, Markus},
  title     = {Die Abschaffung der Studiengeb{\"u}hren ist der falsche Weg!},
  series = {Der Ordnungspolitische Kommentar},
  journal   = {Der Ordnungspolitische Kommentar},
  year      = {2010},
  language  = {de}
}
@article{EmontsBuyel2023,
  author    = {Emonts, Jessica and Buyel, Johannes Felix},
  title     = {An overview of descriptors to capture protein properties - Tools and perspectives in the context of QSAR modeling},
  series = {Computational and Structural Biotechnology Journal},
  journal   = {Computational and Structural Biotechnology Journal},
  number    = {21},
  publisher = {Research Network of Computational and Structural Biotechnology},
  address   = {Gotenburg},
  issn      = {2001-0370 (online-ressource)},
  doi       = {10.1016/j.csbj.2023.05.022},
  pages     = {3234 -- 3247},
  year      = {2023},
  abstract  = {Proteins are important ingredients in food and feed, they are the active components of many pharmaceutical products, and they are necessary, in the form of enzymes, for the success of many technical processes. However, production can be challenging, especially when using heterologous host cells such as bacteria to express and assemble recombinant mammalian proteins. The manufacturability of proteins can be hindered by low solubility, a tendency to aggregate, or inefficient purification. Tools such as in silico protein engineering and models that predict separation criteria can overcome these issues but usually require the complex shape and surface properties of proteins to be represented by a small number of quantitative numeric values known as descriptors, as similarly used to capture the features of small molecules. Here, we review the current status of protein descriptors, especially for application in quantitative structure activity relationship (QSAR) models. First, we describe the complexity of proteins and the properties that descriptors must accommodate. Then we introduce descriptors of shape and surface properties that quantify the global and local features of proteins. Finally, we highlight the current limitations of protein descriptors and propose strategies for the derivation of novel protein descriptors that are more informative.},
  language  = {en}
}