@book{StaatHeitzer2003,
  author    = {Staat, Manfred and Heitzer, Michael},
  title     = {Numerical methods for limit and shakedown analysis. Deterministic and probabilistic problems.},
  publisher = {John von Neumann Institute for Computing (NIC)},
  address   = {J{\"u}lich},
  isbn      = {3-00-010001-6},
  pages     = {2, xiii, 282 Seiten},
  year      = {2003},
  language  = {en}
}
@article{ZiemonsKleinesErkenetal.1997,
  author    = {Ziemons, Karl and Kleines, H. and Erken, I. and Knoben, J. and Zwoll, K.},
  title     = {IME-DV Projekt: M-FIRBe, Multi-Modality Functional Imaging for Brain Research},
  series = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen},
  journal   = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen},
  editor    = {Lehmann, Thomas Martin},
  publisher = {Verl. der. Augustinus-Buchh.},
  address   = {Aachen},
  isbn      = {3-86073-519-5},
  pages     = {363 -- 366},
  year      = {1997},
  language  = {de}
}
@article{KleinesErkiZiemonsetal.1997,
  author    = {Kleines, H. and Erki, I. and Ziemons, Karl and Zwoll, K.},
  title     = {ATM- und Multimedia Pilotsystem im Rahmen des Projektes M-FIBRe Aufbau und Erfahrungen},
  series = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen},
  journal   = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen},
  editor    = {Lehmann, Thomas Martin},
  publisher = {Verl. der. Augustinus-Buchh.},
  address   = {Aachen},
  isbn      = {3-86073-519-5},
  pages     = {241 -- 248},
  year      = {1997},
  language  = {de}
}
@article{ErkiKleinesZiemonsetal.1997,
  author    = {Erki, I. and Kleines, H. and Ziemons, Karl and Zwoll, K.},
  title     = {Interaktives System zur Darstellung funktionaler Bilddaten},
  series = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen},
  journal   = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen},
  editor    = {Lehmann, Thomas Martin},
  publisher = {Verl. der. Augustinus-Buchh.},
  address   = {Aachen},
  isbn      = {3-86073-519-5},
  pages     = {249 -- 254},
  year      = {1997},
  language  = {de}
}
@article{BayerTemizArtmannDigeletal.2020,
  author    = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen},
  title     = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model},
  series = {Cellular Physiology and Biochemistry},
  volume    = {54},
  journal   = {Cellular Physiology and Biochemistry},
  publisher = {Cell Physiol Biochem Press},
  address   = {D{\"u}sseldorf},
  issn      = {1421-9778},
  doi       = {10.33594/000000225},
  pages     = {371 -- 383},
  year      = {2020},
  abstract  = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.},
  language  = {en}
}
@article{KirchhofKraft2012,
  author    = {Kirchhof, Michael and Kraft, Bodo},
  title     = {Hybrides Vorgehensmodell : Agile und klassische Methoden im Projekt passend kombinieren},
  series = {ProjektMagazin},
  journal   = {ProjektMagazin},
  number    = {11},
  publisher = {Berleb Media},
  address   = {Taufkirchen},
  pages     = {11 Seiten},
  year      = {2012},
  abstract  = {Agil ist im Trend und immer mehr Unternehmen, die ihre Projekte bisher nach klassischen Prinzipien durchf{\"u}hrten, denken {\"u}ber den Einsatz agiler Methoden nach. Doch selbst wenn die Organisation bereits beide Philosophien unterst{\"u}tzt, gilt f{\"u}r ein Projekt meist die klare Vorgabe: agil oder klassisch. Es gibt aber noch einen anderen Ansatz, mit diesen "unterschiedlichen Welten" umzugehen: Und zwar die beiden Philosophien innerhalb eines Projekts zu kombinieren. Wie dies in der Praxis aussehen und gelingen kann, zeigen Dr. Michael Kirchhof und Prof. Dr. Bodo Kraft in diesem Beitrag.},
  language  = {de}
}
@article{SchoeningBaecker2012,
  author    = {Sch{\"o}ning, Michael Josef and B{\"a}cker, Matthias},
  title     = {Chip-basierte Sensoren f{\"u}r die Biotechnik},
  volume    = {13},
  number    = {2},
  publisher = {BIOCOM},
  address   = {Berlin},
  issn      = {1611-0854},
  pages     = {4 Seiten},
  year      = {2012},
  language  = {de}
}
@article{HasanKeilStaatetal.2012,
  author    = {Hasan, Istabrak and Keil, Ludger and Staat, Manfred and Wahl, Gerhard and Bourauel, Christoph},
  title     = {Determination of the frictional coefficient of the implant-antler interface : experimental approach},
  series = {Biomedical Engineering / Biomedizinische Technik},
  volume    = {57},
  journal   = {Biomedical Engineering / Biomedizinische Technik},
  number    = {5},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {1862-278X},
  pages     = {359 -- 363},
  year      = {2012},
  abstract  = {The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5-0.7 and 0.3-0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.},
  language  = {en}
}
@article{BassamHeschelerTemizArtmannetal.2012,
  author    = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya},
  title     = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin},
  series = {BMC Biophysics},
  volume    = {5},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {2046-1682},
  doi       = {10.1186/2046-1682-5-16},
  year      = {2012},
  abstract  = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.},
  language  = {en}
}
@article{Grotendorst2012,
  author    = {Grotendorst, Johannes},
  title     = {Supercomputer programmieren - ein besonderes Studienangebot in J{\"u}lich},
  series = {Junge Wissenschaft},
  volume    = {27},
  journal   = {Junge Wissenschaft},
  number    = {94},
  publisher = {Verlag Junge Wissenschaft},
  address   = {D{\"u}sseldorf},
  isbn      = {0179-8529},
  pages     = {12 -- 14},
  year      = {2012},
  language  = {de}
}