@inproceedings{DammRitzStrauch2011, author = {Damm, Sebastian and Ritz, Thomas and Strauch, Jakob}, title = {Adaption of archetype patterns for mobile cloud-based business apps}, series = {2011 IEEE International Conference on Pervasive Computing and Communications workshops (PerCom workshops 2011) : Seattle, Washington, USA, 21 - 25 March 2011}, booktitle = {2011 IEEE International Conference on Pervasive Computing and Communications workshops (PerCom workshops 2011) : Seattle, Washington, USA, 21 - 25 March 2011}, publisher = {IEEE Service Center}, address = {Piscataway, NJ}, isbn = {978-1-61284-938-6 (Print)}, doi = {10.1109/PERCOMW.2011.5766849}, pages = {100 -- 105}, year = {2011}, language = {en} } @inproceedings{FuchsRitzHalbachetal.2011, author = {Fuchs, Britta and Ritz, Thomas and Halbach, Bastian and Hartl, Florian}, title = {Blended shopping : interactivity and individualization}, series = {Proceedings of the International Conference on e-Business : Seville, Spain, 18 - 21 July 2011 ; [... integrated in the ICETE (International Conference on e-Business and Telecommunications) joint conference]}, booktitle = {Proceedings of the International Conference on e-Business : Seville, Spain, 18 - 21 July 2011 ; [... integrated in the ICETE (International Conference on e-Business and Telecommunications) joint conference]}, editor = {Marca, David A.}, publisher = {SciTePress}, address = {[Lissabon]}, isbn = {978-989-8425-70-6}, pages = {47 -- 52}, year = {2011}, language = {en} } @inproceedings{KirchhofKraft2011, author = {Kirchhof, Michael and Kraft, Bodo}, title = {Dogmatisches „Entweder agil oder klassisch" im Projektmanagement hat ausgedient - die richtige Mischung macht's}, series = {Projekt-Sternstunden : strahlende Erfolge durch Kompetenz}, booktitle = {Projekt-Sternstunden : strahlende Erfolge durch Kompetenz}, publisher = {GPM}, address = {N{\"u}rnberg}, isbn = {978-3-924841-60-7}, pages = {414 -- 425}, year = {2011}, language = {de} } @article{SiersSoegtropBorrmannetal.2011, author = {Siers, Carsten and S{\"o}gtrop, Christian and Borrmann, Arne and Hoepner, Gert}, title = {Vernetzung von Kultur und Struktur}, series = {Sales-Business : der Navigator f{\"u}r Vertrieb, Verkauf und Strategie}, volume = {20}, journal = {Sales-Business : der Navigator f{\"u}r Vertrieb, Verkauf und Strategie}, number = {5}, publisher = {Springer Gabler}, address = {Wiesbaden}, issn = {1616-7902}, doi = {10.1365/s35141-011-0093-5}, pages = {32 -- 34}, year = {2011}, language = {de} } @inproceedings{BudaWollert2011, author = {Buda, Aurel and Wollert, J{\"o}rg}, title = {Leistungsbewertung von Ultra Wideband Funktechnologien nach ECMA 368 f{\"u}r den Einsatz in industriellen Kommunikationssystemen}, series = {Kommunikation in der Automation : Magdeburg, 27. - 28.09.2011 ; 2. Jahreskolloquium Kommunikation in der Automation ; KOMMA 2011 / Ulrich Jumar ... (Hrsg.)}, booktitle = {Kommunikation in der Automation : Magdeburg, 27. - 28.09.2011 ; 2. Jahreskolloquium Kommunikation in der Automation ; KOMMA 2011 / Ulrich Jumar ... (Hrsg.)}, publisher = {ifak, Institut f{\"u}r Automation und Kommunikation e.V. Magdeburg an der Otto-von-Guericke-Universit{\"a}t Magdeburg}, address = {Magdeburg}, organization = {Jahreskolloquium Kommunikation in der Automation <2, 2011, Magdeburg>}, isbn = {978-3-940961-58-7}, pages = {1 CD-ROM}, year = {2011}, language = {de} } @inproceedings{StieglitzWollert2011, author = {Stieglitz, Kristian and Wollert, J{\"o}rg}, title = {Approach of using ultra-wideband-radio in industrial real-time ethernet networks}, series = {The 4th International Multi-Conference on Engineering and Technological Innovation : IMETI : July 19th - July 22nd, 2011, Orlando, Florida, USA}, booktitle = {The 4th International Multi-Conference on Engineering and Technological Innovation : IMETI : July 19th - July 22nd, 2011, Orlando, Florida, USA}, organization = {International Multi-Conference on Engineering and Technological Innovation <4, 2011, Orlando, Fla.>}, pages = {1 -- 6}, year = {2011}, language = {en} } @article{FuchsRitz2011, author = {Fuchs, Britta and Ritz, Thomas}, title = {Absatzkan{\"a}le kaum verkn{\"u}pft}, series = {IT-Mittelstand : IT-Business im Mittelstand}, volume = {2011}, journal = {IT-Mittelstand : IT-Business im Mittelstand}, number = {9}, publisher = {Medienhaus-Verlag}, address = {Bergisch-Gladbach}, pages = {16}, year = {2011}, language = {de} } @article{RaabKappelKraemeretal.2011, author = {Raab, Monika and Kappel, Sven and Kr{\"a}mer, Andrea and Sanhaji, Mourad and Matthess, Yves and Kurunci-Csacsko, Elisabeth and Calzada-Wack, Julia and Rathkolb, Birgit and Rosman, Jan and Adler, Thure and Busch, Dirk H. and Esposito, Irene and Fuchs, Helmut and Gailus-Durner, Val{\´e}rie and Klingenspor, Martin and Wolf, Eckhard and S{\"a}nger, Nicole and Prinz, Florian and Hrabe de Angelis, Martin and Seibler, Jost and Yuan, Juping and Bergmann, Martin and Knecht, Rainald and Kreft, Bertolt and Strebhardt, Klaus}, title = {Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells}, series = {Nature Communications}, volume = {2}, journal = {Nature Communications}, number = {395}, publisher = {Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/ncomms1395}, pages = {1 -- 11}, year = {2011}, language = {en} } @article{HasegawaKapelyukhTaharaetal.2011, author = {Hasegawa, Maki and Kapelyukh, Yury and Tahara, Harunobu and Seibler, Jost and Rode, Anja and Krueger, Sylvia and Lee, Dongtao N. and Wolf, C. Roland and Scheer, Nico}, title = {Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line}, series = {Molecular Pharmacology}, volume = {80}, journal = {Molecular Pharmacology}, number = {33}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.111.071845}, pages = {518 -- 528}, year = {2011}, language = {en} } @article{JordanKruegerWillmesetal.2011, author = {Jordan, Sabine D. and Kr{\"u}ger, Markus and Willmes, Diana M. and Redemann, Nora and Wunderlich, F. Thomas and Br{\"o}nneke, Hella S. and Merkwirth, Carsten and Kashkar, Hamid and Olkkonen, Vesa M. and B{\"o}ttger, Thomas and Braun, Thomas and Seibler, Jost and Br{\"u}ning, Jens C.}, title = {Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism}, series = {Nature Cell Biology}, volume = {13}, journal = {Nature Cell Biology}, number = {4}, publisher = {Nature}, address = {New York}, issn = {1465-7392}, doi = {10.1038/ncb2211}, pages = {434 -- 446}, year = {2011}, abstract = {The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143-145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143-ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.}, language = {en} }