@article{WeldenSchejaSchoeningetal.2018, author = {Welden, Rene and Scheja, Sabrina and Sch{\"o}ning, Michael Josef and Wagner, Patrick and Wagner, Torsten}, title = {Electrochemical Evaluation of Light-Addressable Electrodes Based on TiO2 for the Integration in Lab-on-Chip Systems}, series = {physica status solidi a : applications and materials sciences}, volume = {215}, journal = {physica status solidi a : applications and materials sciences}, number = {15}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201800150}, pages = {Article number 1800150}, year = {2018}, abstract = {In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol-gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated.}, language = {en} } @inproceedings{JungFrotscherStaat2018, author = {Jung, Alexander and Frotscher, Ralf and Staat, Manfred}, title = {Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts}, series = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, booktitle = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, pages = {11 Seiten}, year = {2018}, abstract = {The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.}, language = {en} } @article{MuellerBeckersMussmannetal.2018, author = {M{\"u}ller, Janina and Beckers, Mario and Mußmann, Nina and Bongaerts, Johannes and B{\"u}chs, Jochen}, title = {Elucidation of auxotrophic deficiencies of Bacillus pumilus DSM 18097 to develop a defined minimal medium}, series = {Microbial Cell Factories}, volume = {17}, journal = {Microbial Cell Factories}, number = {1}, publisher = {BioMed Central}, issn = {1475-2859}, doi = {10.1186/s12934-018-0956-1}, pages = {Article No. 106}, year = {2018}, abstract = {Background Culture media containing complex compounds like yeast extract or peptone show numerous disadvantages. The chemical composition of the complex compounds is prone to significant variations from batch to batch and quality control is difficult. Therefore, the use of chemically defined media receives more and more attention in commercial fermentations. This concept results in better reproducibility, it simplifies downstream processing of secreted products and enable rapid scale-up. Culturing bacteria with unknown auxotrophies in chemically defined media is challenging and often not possible without an extensive trial-and-error approach. In this study, a respiration activity monitoring system for shake flasks and its recent version for microtiter plates were used to clarify unknown auxotrophic deficiencies in the model organism Bacillus pumilus DSM 18097. Results Bacillus pumilus DSM 18097 was unable to grow in a mineral medium without the addition of complex compounds. Therefore, a rich chemically defined minimal medium was tested containing basically all vitamins, amino acids and nucleobases, which are essential ingredients of complex components. The strain was successfully cultivated in this medium. By monitoring of the respiration activity, nutrients were supplemented to and omitted from the rich chemically defined medium in a rational way, thus enabling a systematic and fast determination of the auxotrophic deficiencies. Experiments have shown that the investigated strain requires amino acids, especially cysteine or histidine and the vitamin biotin for growth. Conclusions The introduced method allows an efficient and rapid identification of unknown auxotrophic deficiencies and can be used to develop a simple chemically defined tailor-made medium. B. pumilus DSM 18097 was chosen as a model organism to demonstrate the method. However, the method is generally suitable for a wide range of microorganisms. By combining a systematic combinatorial approach based on monitoring the respiration activity with cultivation in microtiter plates, high throughput experiments with high information content can be conducted. This approach facilitates media development, strain characterization and cultivation of fastidious microorganisms in chemically defined minimal media while simultaneously reducing the experimental effort.}, language = {en} } @book{Huening2018, author = {H{\"u}ning, Felix}, title = {Embedded Design For IoT With Renesas Synergy}, publisher = {Renesas Electronics}, address = {D{\"u}sseldorf}, pages = {143 S.}, year = {2018}, language = {en} } @article{ValeroBungCrookston2018, author = {Valero, Daniel and Bung, Daniel B. and Crookston, B.M.}, title = {Energy dissipation of a Type III basin under design and adverse conditions for stepped and smooth spillways}, series = {Journal of Hydraulic Engineering}, volume = {144}, journal = {Journal of Hydraulic Engineering}, number = {7}, publisher = {ASCE}, address = {Reston, Va.}, issn = {0733-9429}, doi = {10.1061/(ASCE)HY.1943-7900.0001482}, year = {2018}, abstract = {New information regarding the influence of a stepped chute on the hydraulic performance of the United States Bureau of Reclamation (Reclamation) Type III hydraulic jump stilling basin is presented for design (steady) and adverse (decreasing tailwater) conditions. Using published experimental data and computational fluid dynamics (CFD) models, this paper presents a detailed comparison between smooth-chute and stepped-chute configurations for chute slopes of 0.8H:1V and 4H:1V and Froude numbers (F) ranging from 3.1 to 9.5 for a Type III basin designed for F = 8. For both stepped and smooth chutes, the relative role of each basin element was quantified, up to the most hydraulic extreme case of jump sweep-out. It was found that, relative to a smooth chute, the turbulence generated by a stepped chute causes a higher maximum velocity decay within the stilling basin, which represents an enhancement of the Type III basin's performance but also a change in the relative role of the basin elements. Results provide insight into the ability of the CFD models [unsteady Reynolds-averaged Navier-Stokes (RANS) equations with renormalization group (RNG) k-ϵ turbulence model and volume-of-fluid (VOF) for free surface tracking] to predict the transient basin flow structure and velocity profiles. Type III basins can perform adequately with a stepped chute despite the effects steps have on the relative role of each basin element. It is concluded that the classic Type III basin design, based upon methodology by reclamation specific to smooth chutes, can be hydraulically improved for the case of stepped chutes for design and adverse flow conditions using the information presented herein.}, language = {en} } @incollection{LeiseAltherrPelz2018, author = {Leise, Philipp and Altherr, Lena and Pelz, Peter F.}, title = {Energy-Efficient design of a water supply system for skyscrapers by mixed-integer nonlinear programming}, series = {Operations Research Proceedings 2017}, booktitle = {Operations Research Proceedings 2017}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-89919-0}, doi = {10.1007/978-3-319-89920-6_63}, year = {2018}, abstract = {The energy-efficiency of technical systems can be improved by a systematic design approach. Technical Operations Research (TOR) employs methods known from Operations Research to find a global optimal layout and operation strategy of technical systems. We show the practical usage of this approach by the systematic design of a decentralized water supply system for skyscrapers. All possible network options and operation strategies are modeled by a Mixed-Integer Nonlinear Program. We present the optimal system found by our approach and highlight the energy savings compared to a conventional system design.}, language = {en} } @article{TekinAshikagaHorikawaetal.2018, author = {Tekin, Nurettin and Ashikaga, Mitsugu and Horikawa, Atsushi and Funke, Harald}, title = {Enhancement of fuel flexibility of industrial gas turbines by development of innovative hydrogen combustion systems}, series = {Gas for energy}, journal = {Gas for energy}, number = {2}, publisher = {Vulkan-Verlag}, address = {Essen}, pages = {4}, year = {2018}, abstract = {For fuel flexibility enhancement hydrogen represents a possible alternative gas turbine fuel within future low emission power generation, in case of hydrogen production by the use of renewable energy sources such as wind energy or biomass. Kawasaki Heavy Industries, Ltd. (KHI) has research and development projects for future hydrogen society; production of hydrogen gas, refinement and liquefaction for transportation and storage, and utilization with gas turbine / gas engine for the generation of electricity. In the development of hydrogen gas turbines, a key technology is the stable and low NOx hydrogen combustion, especially Dry Low Emission (DLE) or Dry Low NOx (DLN) hydrogen combustion. Due to the large difference in the physical properties of hydrogen compared to other fuels such as natural gas, well established gas turbine combustion systems cannot be directly applied for DLE hydrogen combustion. Thus, the development of DLE hydrogen combustion technologies is an essential and challenging task for the future of hydrogen fueled gas turbines. The DLE Micro-Mix combustion principle for hydrogen fuel has been in development for many years to significantly reduce NOx emissions. This combustion principle is based on cross-flow mixing of air and gaseous hydrogen which reacts in multiple miniaturized "diffusion-type" flames. The major advantages of this combustion principle are the inherent safety against flashback and the low NOx-emissions due to a very short residence time of the reactants in the flame region of the micro-flames.}, language = {en} } @inproceedings{HofmannMatareNeumannetal.2018, author = {Hofmann, Till and Matar{\´e}, Victor and Neumann, Tobias and Sch{\"o}nitz, Sebastian and Henke, Christoph and Limpert, Nicolas and Niemueller, Tim and Ferrein, Alexander and Jeschke, Sabina and Lakemeyer, Gerhard}, title = {Enhancing Software and Hardware Reliability for a Successful Participation in the RoboCup Logistics League 2017}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-00308-1}, doi = {10.1007/978-3-030-00308-1_40}, pages = {486 -- 497}, year = {2018}, language = {en} } @inproceedings{BrockmannSultanowCzarnecki2018, author = {Brockmann, Carsten and Sultanow, Eldar and Czarnecki, Christian}, title = {Enterprise architectures between agility and traditional methodologies}, series = {GI Edition Proceedings Band 285 Workshops der INFORMATIK 2018}, booktitle = {GI Edition Proceedings Band 285 Workshops der INFORMATIK 2018}, editor = {Czarnecki, Christian and Brockmann, Carsten and Sultanow, Eldar and Koschmider, Agnes and Selzer, Annika and Gesellschaft f{\"u}r Informatik e. V.,}, publisher = {K{\"o}llen}, address = {Bonn}, isbn = {9783885796794}, issn = {1617-5468}, pages = {1 Seite}, year = {2018}, abstract = {For this year's workshop on Enterpirse Architecture in Research and Practice we have received eight submissions from which four have passed the rigorous peer-review. The acceptance quote of 50\% assures that only advancements in the field are included in our workshop.}, language = {en} } @incollection{RoethDeutskensKreiskoetheretal.2018, author = {R{\"o}th, Thilo and Deutskens, Christoph and Kreisk{\"o}ther, Kai and Heimes, Heiner Hans and Schittny, Bastian and Ivanescu, Sebastian and Kleine B{\"u}ning, Max and Reinders, Christian and Wessels, Saskia and Haunreiter, Andreas and Reisgen, Uwe and Thiele, Regina and Hameyer, Kay and Doncker, Rik W. de and Sauer, Uwe and Hoek, Hauke van and H{\"u}bner, Mareike and Hennen, Martin and Stolze, Thilo and Vetter, Andreas and Hagedorn, J{\"u}rgen and M{\"u}ller, Dirk and Rewitz, Kai and Wesseling, Mark and Flieger, Bj{\"o}rn}, title = {Entwicklung von elektrofahrzeugspezifischen Systemen}, series = {Elektromobilit{\"a}t}, booktitle = {Elektromobilit{\"a}t}, publisher = {Springer Vieweg}, address = {Berlin, Heidelberg}, isbn = {978-3-662-53137-2}, doi = {10.1007/978-3-662-53137-2_6}, pages = {279 -- 386}, year = {2018}, abstract = {Die Batterie ist eine der absolut zentralen Komponenten des Elektrofahrzeugs. Die serielle Entwicklung und Produktion dieser Batterien und die Verbesserung der Leistungen wird entscheidend f{\"u}r den Erfolg der Elektromobilit{\"a}t sein. Die Batterie ist jedoch nicht das einzige elektrofahrzeugspezifische System, das neu entwickelt, umkonzipiert oder verbessert werden muss. So sind ebenso die Entwicklung der neuen Fahrzeugstruktur sowie des elektrifizierten Antriebsstranges Teil dieses Kapitels. Weiterhin wird ein Blick auf das bedeutende Thema des Thermomanagements geworfen.}, language = {de} }