@incollection{WolfKapelyukhScheeretal.2015, author = {Wolf, C. Roland and Kapelyukh, Yury and Scheer, Nico and Henderson, Colin J.}, title = {Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs}, editor = {Wilson, Alan G. E.}, publisher = {RSC Publ.}, address = {Cambridge}, isbn = {978-1-78262-778-4}, doi = {10.1039/9781782622376-00152}, pages = {152 -- 176}, year = {2015}, abstract = {The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.}, language = {en} } @inproceedings{HorikawaOkadaKazarietal.2015, author = {Horikawa, Atsushi and Okada, Kunio and Kazari, Masahide and Funke, Harald and Keinz, Jan and Kusterer, Karsten and Haj Ayed, Anis}, title = {Application of Low NOx Micro-Mix Hydrogen Combustion to Industrial Gas Turbine Combustor and Conceptual Design}, series = {Proceedings of International Gas Turbine Congress 2015 Tokyo November 15-20, 2015, Tokyo, Japan}, booktitle = {Proceedings of International Gas Turbine Congress 2015 Tokyo November 15-20, 2015, Tokyo, Japan}, isbn = {978-4-89111-008-6}, pages = {141 -- 146}, year = {2015}, language = {en} } @incollection{KrollLudwigs2015, author = {Kroll-Ludwigs, Kathrin}, title = {Art. 5 Rom III-Regulation (choice of applicable law by the parties)}, series = {Rome Regulations : commentary}, booktitle = {Rome Regulations : commentary}, editor = {Calliess, Gralf-Peter}, edition = {2nd ed.}, publisher = {Wolters Kluwer}, isbn = {9789041147547}, year = {2015}, language = {en} } @incollection{CalliessKrollLudwigs2015, author = {Calliess, Gralf-Peter and Kroll-Ludwigs, Kathrin}, title = {Art. 6 Rome III-Regulation (consent and material validity)}, series = {Rome Regulations : commentary}, booktitle = {Rome Regulations : commentary}, publisher = {Wolters Kluwer}, isbn = {9789041147547}, year = {2015}, language = {en} } @incollection{KrollLudwigs2015, author = {Kroll-Ludwigs, Kathrin}, title = {Art. 7 Rome III-Regulation (formal validity)}, series = {Rome Regulations : commentary}, booktitle = {Rome Regulations : commentary}, editor = {Colliess, Gralf-Peter}, edition = {2nd ed.}, publisher = {Wolters Kluwer}, isbn = {9789041147547}, year = {2015}, language = {en} } @inproceedings{SchaenzleAltherrEdereretal.2015, author = {Sch{\"a}nzle, Christian and Altherr, Lena and Ederer, Thorsten and Lorenz, Ulf and Pelz, Peter F.}, title = {As good as it can be: Ventilation system design by a combined scaling and discrete optimization method}, series = {Proceedings of FAN 2015}, booktitle = {Proceedings of FAN 2015}, pages = {1 -- 11}, year = {2015}, abstract = {The understanding that optimized components do not automatically lead to energy-efficient systems sets the attention from the single component on the entire technical system. At TU Darmstadt, a new field of research named Technical Operations Research (TOR) has its origin. It combines mathematical and technical know-how for the optimal design of technical systems. We illustrate our optimization approach in a case study for the design of a ventilation system with the ambition to minimize the energy consumption for a temporal distribution of diverse load demands. By combining scaling laws with our optimization methods we find the optimal combination of fans and show the advantage of the use of multiple fans.}, language = {en} } @article{DiktaKuehlheimMendoncaetal.2015, author = {Dikta, Gerhard and K{\"u}hlheim, Ren{\´e} and Mendonca, Jorge and Una-Alcarez, Jacobo de}, title = {Asymptotic representation of presmoothed Kaplan-Meier integrals with covariates in a semiparametric censorship model}, series = {Journal of Statistical Planning and Inference}, volume = {Vol. 171}, journal = {Journal of Statistical Planning and Inference}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0378-3758}, doi = {10.1016/j.jspi.2015.12.001}, pages = {10 -- 37}, year = {2015}, language = {en} } @inproceedings{PirovanoSeefeldtDachwaldetal.2015, author = {Pirovano, Laura and Seefeldt, Patric and Dachwald, Bernd and Noomen, Ron}, title = {Attitude and Orbital Dynamics Modeling for an Uncontrolled Solar-Sail Experiment in Low-Earth Orbit}, series = {25th International Symposium on Spaceflight Dynamics, 2015, Munich, Germany}, booktitle = {25th International Symposium on Spaceflight Dynamics, 2015, Munich, Germany}, pages = {15 S.}, year = {2015}, language = {en} } @inproceedings{PirovanoSeefeldtDachwaldetal.2015, author = {Pirovano, Laura and Seefeldt, Patric and Dachwald, Bernd and Noomen, Ron}, title = {Attitude and orbital modeling of an uncontrolled solar-sail experiment in low-Earth orbit}, series = {25th International Symposium on Space Flight Dynamics ISSFD}, booktitle = {25th International Symposium on Space Flight Dynamics ISSFD}, pages = {1 -- 15}, year = {2015}, abstract = {Gossamer-1 is the first project of the three-step Gossamer roadmap, the purpose of which is to develop, prove and demonstrate that solar-sail technology is a safe and reliable propulsion technique for long-lasting and high-energy missions. This paper firstly presents the structural analysis performed on the sail to understand its elastic behavior. The results are then used in attitude and orbital simulations. The model considers the main forces and torques that a satellite experiences in low-Earth orbit coupled with the sail deformation. Doing the simulations for varying initial conditions in attitude and rotation rate, the results show initial states to avoid and maximum rotation rates reached for correct and faulty deployment of the sail. Lastly comparisons with the classic flat sail model are carried out to test the hypothesis that the elastic behavior does play a role in the attitude and orbital behavior of the sail}, language = {en} } @article{Pietsch2015, author = {Pietsch, Wolfram}, title = {Augmenting voice of the customer analysis by analysis of belief}, series = {QFD-Forum}, journal = {QFD-Forum}, number = {30}, issn = {1431-6951}, pages = {1 -- 5}, year = {2015}, language = {en} }