@incollection{MacdonaldMcGrathAppourchauxetal.2014, author = {Macdonald, Malcolm and McGrath, C. and Appourchaux, T. and Dachwald, Bernd and Finsterle, W. and Gizon, L. and Liewer, P. C. and McInnes, Colin R. and Mengali, G. and Seboldt, Wolfgang and Sekii, T. and Solanki, S. K. and Velli, M. and Wimmer-Schweingruber, R. F. and Spietz, Peter and Reinhard, Ruedeger}, title = {Gossamer roadmap technology reference study for a solar polar mission}, series = {Advances in solar sailing}, booktitle = {Advances in solar sailing}, editor = {Macdonald, Malcolm}, publisher = {Springer}, address = {Berlin, Heidelberg}, isbn = {978-3-642-34906-5}, doi = {10.1007/978-3-642-34907-2_17}, pages = {243 -- 257}, year = {2014}, abstract = {A technology reference study for a solar polar mission is presented. The study uses novel analytical methods to quantify the mission design space including the required sail performance to achieve a given solar polar observation angle within a given timeframe and thus to derive mass allocations for the remaining spacecraft sub-systems, that is excluding the solar sail sub-system. A parametric, bottom-up, system mass budget analysis is then used to establish the required sail technology to deliver a range of science payloads, and to establish where such payloads can be delivered to within a given timeframe. It is found that a solar polar mission requires a solar sail of side-length 100-125 m to deliver a 'sufficient value' minimum science payload, and that a 2.5 μm sail film substrate is typically required, however the design is much less sensitive to the boom specific mass.}, language = {en} } @article{LeandroBungCarvalho2014, author = {Leandro, J. and Bung, Daniel Bernhard and Carvalho, R.}, title = {Measuring void fraction and velocity fields of a stepped spillway for skimming flow using non-intrusive methods}, series = {Experiments in fluids}, journal = {Experiments in fluids}, number = {55}, publisher = {Springer Nature}, address = {Heidelberg}, issn = {0723-4864 (Print) ; 1432-1114 (Online)}, doi = {10.1007/s00348-014-1732-6}, pages = {Art. 1732}, year = {2014}, language = {en} } @article{KueppersSteffenHellmuthetal.2014, author = {K{\"u}ppers, Tobias and Steffen, Victoria and Hellmuth, Hendrik and O'Connell, Timothy and Bongaerts, Johannes and Maurer, Karl-Heinz and Wiechert, Wolfgang}, title = {Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer}, series = {Microbial cell factories}, volume = {13}, journal = {Microbial cell factories}, publisher = {BioMed Central}, address = {London}, issn = {1475-2859 (E-Journal)}, doi = {10.1186/1475-2859-13-46}, pages = {Article No. 46}, year = {2014}, language = {en} } @article{PhamStaat2014, author = {Pham, Phu Tinh and Staat, Manfred}, title = {FEM-based shakedown analysis of hardening structures}, series = {Asia Pacific journal on computational engineering}, journal = {Asia Pacific journal on computational engineering}, number = {1}, publisher = {SpringerOpen}, address = {Berlin}, issn = {2196-1166 (E-Journal)}, doi = {10.1186/2196-1166-1-4}, pages = {Article No. 4}, year = {2014}, abstract = {This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature.}, language = {en} } @article{HaagZontarSchleupenetal.2014, author = {Haag, S. and Zontar, D. and Schleupen, Josef and M{\"u}ller, T. and Brecher, C.}, title = {Chain of refined perception in self-optimizing assembly of micro-optical systems}, series = {Journal of sensors and sensor systems}, volume = {3}, journal = {Journal of sensors and sensor systems}, number = {1}, publisher = {Copernicus Publ.}, address = {G{\"o}ttingen}, issn = {2194-878X}, doi = {10.5194/jsss-3-87-2014}, pages = {87 -- 95}, year = {2014}, abstract = {Today, the assembly of laser systems requires a large share of manual operations due to its complexity regarding the optimal alignment of optics. Although the feasibility of automated alignment of laser optics has been shown in research labs, the development effort for the automation of assembly does not meet economic requirements - especially for low-volume laser production. This paper presents a model-based and sensor-integrated assembly execution approach for flexible assembly cells consisting of a macro-positioner covering a large workspace and a compact micromanipulator with camera attached to the positioner. In order to make full use of available models from computer-aided design (CAD) and optical simulation, sensor systems at different levels of accuracy are used for matching perceived information with model data. This approach is named "chain of refined perception", and it allows for automated planning of complex assembly tasks along all major phases of assembly such as collision-free path planning, part feeding, and active and passive alignment. The focus of the paper is put on the in-process image-based metrology and information extraction used for identifying and calibrating local coordinate systems as well as the exploitation of that information for a part feeding process for micro-optics. Results will be presented regarding the processes of automated calibration of the robot camera as well as the local coordinate systems of part feeding area and robot base.}, language = {en} } @inproceedings{HecklWeilerFleischhakeretal.2014, author = {Heckl, O. H. and Weiler, Sascha and Fleischhaker, Robert and Gebs, Raphael and Budnicki, Aleksander and Wolf, M. and Kleinbauer, Jochen and Russ, S. and Kumkar, M. and Sutter, Dirk H.}, title = {Industry-grade high average power femtosecond light source}, series = {Frontiers in ultrafast optics: Biomedical, scientific, and industrial applications XIV : 1 Februar 2014, San Francisco, USA. - (SPIE proceedings series ; 8972)}, booktitle = {Frontiers in ultrafast optics: Biomedical, scientific, and industrial applications XIV : 1 Februar 2014, San Francisco, USA. - (SPIE proceedings series ; 8972)}, editor = {Heisterkamp, Alexander and Herman, Peter R. and Meunier, Michael and Nolte, Stefan}, publisher = {SPIE, International Society for Optical Engineering}, doi = {10.1117/12.2039337}, pages = {89720P -- 89720P-7}, year = {2014}, language = {en} } @article{ScheerWolf2014, author = {Scheer, Nico and Wolf, C. Roland}, title = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications}, series = {Xenobiotica}, volume = {44}, journal = {Xenobiotica}, number = {2}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1366-5928}, doi = {10.3109/00498254.2013.815831}, pages = {96 -- 108}, year = {2014}, abstract = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.}, language = {en} } @inproceedings{SchirraBauschatWatmuff2014, author = {Schirra, Julian and Bauschat, J.-Michael and Watmuff, J.H.}, title = {Accurate induced drag prediction for highly non-planar lifting systems}, series = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia}, booktitle = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia}, pages = {4 Seiten}, year = {2014}, abstract = {The impact of wake model effects is investigated for two highly non-planar lifting systems. Dependent on the geometrical arrangement of the configuration, the wake model shape is found to considerably affect the estimation. Particularly at higher angles of attack, an accurate estimation based on the common linear wake model approaches is involved.}, language = {en} } @article{HoehrPaulssenBenardetal.2014, author = {Hoehr, Cornelia and Paulßen, Elisabeth and Benard, Francois and Lee, Chris Jaeil and Hou, Xinchi and Badesso, Brian and Ferguson, Simon and Miao, Qing and Yang, Hua and Buckley, Ken and Hanemaayer, Victoire and Zeisler, Stefan and Ruth, Thomas and Celler, Anna and Schaffer, Paul}, title = {⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron}, series = {Nuclear medicine and biology}, volume = {41}, journal = {Nuclear medicine and biology}, number = {5}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-9614}, doi = {10.1016/j.nucmedbio.2013.12.016}, pages = {401 -- 406}, year = {2014}, abstract = {Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27\%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.}, language = {en} } @article{Bernecker2014, author = {Bernecker, Andreas}, title = {Do politicians shirk when reelection is certain? Evidence from the German parliament}, series = {European Journal of Political Economy}, volume = {36}, journal = {European Journal of Political Economy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0176-2680}, doi = {10.1016/j.ejpoleco.2014.07.001}, pages = {55 -- 70}, year = {2014}, abstract = {Does stiffer electoral competition reduce political shirking? For a micro-analysis of this question, I construct a new data set spanning the years 2005 to 2012 covering biographical and political information about German Members of Parliament (MPs), including their attendance rates in voting sessions. For the parliament elected in 2009, I show that indeed opposition party MPs who expect to face a close race in their district show significantly and relevantly lower absence rates in parliament beforehand. MPs of governing parties seem not to react significantly to electoral competition. These results are confirmed by an analysis of the parliament elected in 2005, by several robustness checks, and also by employing an instrumental variable strategy exploiting convenient peculiarities of the German electoral system. The study also shows how MPs elected via party lists react to different levels of electoral competition.}, language = {en} }