@inproceedings{FingerBraunBil2018, author = {Finger, Felix and Braun, Carsten and Bil, Cees}, title = {Case studies in initial sizing for hybrid-electric general aviation aircraft}, series = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio}, booktitle = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio}, doi = {10.2514/6.2018-5005}, year = {2018}, language = {en} } @misc{CapitainLukebaUlberetal.2018, author = {Capitain, C. C. and Lukeba, L. and Ulber, Roland and Tippk{\"o}tter, Nils}, title = {Biomimetische Klebstoffe aus Organosolv-Lignin}, series = {Chemie Ingenieur Technik}, volume = {90}, journal = {Chemie Ingenieur Technik}, number = {9}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0009-286X}, doi = {10.1002/cite.201855076}, pages = {1167}, year = {2018}, abstract = {Aufgrund von EU-Regularien und Umweltinitiativen w{\"a}chst der Markt f{\"u}r nachhaltige und abbaubare Klebstoffe stetig. Organosolv (OS)-Lignin ist ein kommerziell wenig ertragreicher Nebenstrom der Lignocellulose-Bioraffinerie. Durch das "Nachahmen" der Adh{\"a}sionseigenschaften mit strukturverwandten Muschel-Aminos{\"a}uren soll OS-Lignin in einen starkes, vollst{\"a}ndig biobasiertes Adh{\"a}siv umgewandelt werden. Funktionsweisend f{\"u}r die Adh{\"a}sion des Muschelklebstoffes ist die Catecholgruppe der Aminos{\"a}ure L-DOPA. Die laccase-katalysierte Polymerisationsreaktion von Lignin und L-DOPA ist schwierig zu kontrollieren, da L-DOPA eine Ringschlussreaktion eingeht. Stattdessen wurde eine zweistufige Reaktion mit einem Diamin als Ankermolek{\"u}l etabliert. Die Catecholgruppe, die im zweiten Schritt enzymatisch an das Lignin-Amin gebunden wird, kann durch Komplexbildung mit Fe(III)-Ionen sowohl zur Adh{\"a}sion als auch zur Koh{\"a}sion des Klebstoffes beitragen. Der Lignin-Catechol-Klebstoff ist frei von petrochemischen Chemikalien und biologisch abbaubar. In ersten Stirnzugversuchen konnte eine Haftkraft von 0,3 MPa erreicht werden.}, language = {de} } @incollection{Finkenberger2018, author = {Finkenberger, Isabel Maria}, title = {Schwellenreiten}, series = {Prozesse reflexiven Entwerfens : Entwerfen und Forschen in Architektur und Landschaft}, booktitle = {Prozesse reflexiven Entwerfens : Entwerfen und Forschen in Architektur und Landschaft}, editor = {Buchert, Margitta}, publisher = {JOVIS Verlag}, address = {Berlin}, isbn = {978-3-86859-558-1}, pages = {208 -- 226}, year = {2018}, language = {de} } @article{KohlerKirschnerHermannsStaatetal.2018, author = {Kohler, Annette and Kirschner-Hermanns, Ruth and Staat, Manfred and Brehmer, Bernhard}, title = {Pathogenese, funktionelle und anatomische Aspekte der weiblichen Belastungsinkontinenz}, series = {Aktuelle Urologie}, volume = {49}, journal = {Aktuelle Urologie}, number = {1}, publisher = {Thieme}, address = {Stuttgart}, issn = {1438-8820}, doi = {10.1055/s-0043-120616}, pages = {47 -- 51}, year = {2018}, abstract = {Der vorliegende Artikel fokussiert sich auf die weibliche Belastungsinkontinenz als Insuffizienz der Speicherfunktion der Blase, auch wenn im klinischen Alltag die Harninkontinenz der Frau h{\"a}ufig verschiedene Ursachen hat und insbesondere eine Belastungsinkontinenz im Alter und bei neurologischer Komorbidit{\"a}t nur selten isoliert vorkommt. Das kleine Becken der Frau ist sowohl als Funktions- als auch als strukturelle Einheit zu betrachten. Dabei unterliegen bei der Frau Blase, Harnr{\"o}hre, Geb{\"a}rmutter und Enddarm sowie die muskul{\"a}ren und ligament{\"o}sen Strukturen des kleinen Beckens durch Fertilit{\"a}tsphase, m{\"o}gliche Schwangerschaften, Geburten und Menopausen-Phase, {\"u}ber das „normale Altern" hinaus, gravierenden Ver{\"a}nderungen. This article focuses on female stress incontinence in the form of pelvic floor dysfunction and urethral sphincter deficiency, although isolated stress incontinence accounts for less than half of all incontinence cases. Especially in women of old age and those with neurological comorbidities, the causes of incontinence are mostly multifactorial. Also it has to be considered that the female bladder, urethra, uterus and rectum as well as the muscular and ligamentous structures of the female pelvis minor are affected by phases of fertility, possible pregnancies, births and menopause in addition to the normal ageing process.}, language = {de} } @incollection{ArtmannMeruvuKizildagetal.2018, author = {Artmann, Gerhard and Meruvu, Haritha and Kizildag, Sefa and Temiz Artmann, Ayseg{\"u}l}, title = {Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_7}, pages = {157 -- 192}, year = {2018}, abstract = {Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative "CellDrum technology" was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.}, language = {en} } @inproceedings{KahmannUschokWegmannetal.2018, author = {Kahmann, Stephanie Lucina and Uschok, Stephan and Wegmann, Kilian and M{\"u}ller, Lars-P. and Staat, Manfred}, title = {Biomechanical multibody model with refined kinematics of the elbow}, series = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, booktitle = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, pages = {11 Seiten}, year = {2018}, abstract = {The overall objective of this study is to develop a new external fixator, which closely maps the native kinematics of the elbow to decrease the joint force resulting in reduced rehabilitation time and pain. An experimental setup was designed to determine the native kinematics of the elbow during flexion of cadaveric arms. As a preliminary study, data from literature was used to modify a published biomechanical model for the calculation of the joint and muscle forces. They were compared to the original model and the effect of the kinematic refinement was evaluated. Furthermore, the obtained muscle forces were determined in order to apply them in the experimental setup. The joint forces in the modified model differed slightly from the forces in the original model. The muscle force curves changed particularly for small flexion angles but their magnitude for larger angles was consistent.}, language = {en} } @inproceedings{HofmannMatareSchifferetal.2018, author = {Hofmann, Till and Matar{\´e}, Victor and Schiffer, Stefan and Ferrein, Alexander and Lakemeyer, Gerhard}, title = {Constraint-based online transformation of abstract plans into executable robot actions}, series = {Proceedings of the 2018 AAAI Spring Symposium on Integrating Representation, Reasoning, Learning, and Execution for Goal Directed Autonomy}, booktitle = {Proceedings of the 2018 AAAI Spring Symposium on Integrating Representation, Reasoning, Learning, and Execution for Goal Directed Autonomy}, pages = {549 -- 553}, year = {2018}, language = {en} } @article{ButenwegMarinkovićKubalskietal.2018, author = {Butenweg, Christoph and Marinković, Marko and Kubalski, Thomas and Fehling, Ekkehard and Pfetzing, Thomas and Meyer, Udo}, title = {Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk (Teil 1)}, series = {Ziegelindustrie international : ZI = Brick and tile industry international}, journal = {Ziegelindustrie international : ZI = Brick and tile industry international}, number = {4}, editor = {Voss, Michael}, publisher = {Bauverlag BV GmbH}, address = {G{\"u}tersloh}, issn = {0341-0552}, pages = {30 -- 39}, year = {2018}, abstract = {Im Rahmen des europ{\"a}ischen Verbundprojekts INSYSME wurden von den deutschen Partnern die Systeme IMES und INODIS zur Verbesserung des seismischen Verhaltens von ausgefachten Stahlbetonrahmen entwickelt. Ziel beider Systeme ist es, Stahlbetonrahmen und Ausfachung zu entkoppeln, anstatt die Tragf{\"a}higkeit durch aufwendige und kostspielige zus{\"a}tzliche Bewehrungseinlagen zu erh{\"o}hen. Erste Ergebnisse des Systems IMES f{\"u}r Belastungen in und senkrecht zu der Wandebene werden vorgestellt.}, language = {de} } @inproceedings{WaldmannVeraDachwaldetal.2018, author = {Waldmann, Christoph and Vera, Jean-Pierre de and Dachwald, Bernd and Strasdeit, Henry and Sohl, Frank and Hanff, Hendrik and Kowalski, Julia and Heinen, Dirk and Macht, Sabine and Bestmann, Ulf and Meckel, Sebastian and Hildebrandt, Marc and Funke, Oliver and Gehrt, Jan-J{\"o}ran}, title = {Search for life in ice-covered oceans and lakes beyond Earth}, series = {2018 IEEE/OES Autonomous Underwater Vehicle Workshop, Proceedings November 2018, Article number 8729761}, booktitle = {2018 IEEE/OES Autonomous Underwater Vehicle Workshop, Proceedings November 2018, Article number 8729761}, doi = {10.1109/AUV.2018.8729761}, year = {2018}, abstract = {The quest for life on other planets is closely connected with the search for water in liquid state. Recent discoveries of deep oceans on icy moons like Europa and Enceladus have spurred an intensive discussion about how these waters can be accessed. The challenge of this endeavor lies in the unforeseeable requirements on instrumental characteristics both with respect to the scientific and technical methods. The TRIPLE/nanoAUV initiative is aiming at developing a mission concept for exploring exo-oceans and demonstrating the achievements in an earth-analogue context, exploring the ocean under the ice shield of Antarctica and lakes like Dome-C on the Antarctic continent.}, language = {en} } @incollection{BhattaraiFrotscherStaat2018, author = {Bhattarai, Aroj and Frotscher, Ralf and Staat, Manfred}, title = {Computational Analysis of Pelvic Floor Dysfunction}, series = {Women's Health and Biomechanics}, booktitle = {Women's Health and Biomechanics}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-71574-2}, doi = {10.1007/978-3-319-71574-2_17}, pages = {217 -- 230}, year = {2018}, abstract = {Pelvic floor dysfunction (PFD) is characterized by the failure of the levator ani (LA) muscle to maintain the pelvic hiatus, resulting in the descent of the pelvic organs below the pubococcygeal line. This chapter adopts the modified Humphrey material model to consider the effect of the muscle fiber on passive stretching of the LA muscle. The deformation of the LA muscle subjected to intra-abdominal pressure during Valsalva maneuver is compared with the magnetic resonance imaging (MRI) examination of a nulliparous female. Numerical result shows that the fiber-based Humphrey model simulates the muscle behavior better than isotropic constitutive models. Greater posterior movement of the LA muscle widens the levator hiatus due to lack of support from the anococcygeal ligament and the perineal structure as a consequence of birth-related injury and aging. Old and multiparous females with uncontrolled urogenital and rectal hiatus tend to develop PFDs such as prolapse and incontinence.}, language = {en} }