@article{FigueroaMirandaFengShiuetal.2018, author = {Figueroa-Miranda, Gabriela and Feng, Lingyan and Shiu, Simon Chi-Chin and Dirkzwager, Roderick Marshall and Cheung, Yee-Wai and Tanner, Julian Alexander and Sch{\"o}ning, Michael Josef and Offenh{\"a}usser, Andreas and Mayer, Dirk}, title = {Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability}, series = {Sensor and Actuators B: Chemical}, volume = {255}, journal = {Sensor and Actuators B: Chemical}, number = {P1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.07.117}, pages = {235 -- 243}, year = {2018}, abstract = {Malaria infection remains a significant risk for much of the population of tropical and subtropical areas, particularly in developing countries. Therefore, it is of high importance to develop sensitive, accurate and inexpensive malaria diagnosis tests. Here, we present a novel aptamer-based electrochemical biosensor (aptasensor) for malaria detection by impedance spectroscopy, through the specific recognition between a highly discriminatory DNA aptamer and its target Plasmodium falciparum lactate dehydrogenase (PfLDH). Interestingly, due to the isoelectric point (pI) of PfLDH, the aptasensor response showed an adjustable detection range based on the different protein net-charge at variable pH environments. The specific aptamer recognition allows sensitive protein detection with an expanded detection range and a low detection limit, as well as a high specificity for PfLDH compared to analogous proteins. The specific feasibility of the aptasensor is further demonstrated by detection of the target PfLDH in human serum. Furthermore, the aptasensor can be easily regenerated and thus applied for multiple usages. The robustness, sensitivity, and reusability of the presented aptasensor make it a promising candidate for point-of-care diagnostic systems.}, language = {en} } @article{ButenwegMarinkovićKubalskietal.2018, author = {Butenweg, Christoph and Marinković, Marko and Kubalski, Thomas and Fehling, Ekkehard and Pfetzing, Thomas and Meyer, Udo}, title = {Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk (Teil 1)}, series = {Ziegelindustrie international : ZI = Brick and tile industry international}, journal = {Ziegelindustrie international : ZI = Brick and tile industry international}, number = {4}, editor = {Voss, Michael}, publisher = {Bauverlag BV GmbH}, address = {G{\"u}tersloh}, issn = {0341-0552}, pages = {30 -- 39}, year = {2018}, abstract = {Im Rahmen des europ{\"a}ischen Verbundprojekts INSYSME wurden von den deutschen Partnern die Systeme IMES und INODIS zur Verbesserung des seismischen Verhaltens von ausgefachten Stahlbetonrahmen entwickelt. Ziel beider Systeme ist es, Stahlbetonrahmen und Ausfachung zu entkoppeln, anstatt die Tragf{\"a}higkeit durch aufwendige und kostspielige zus{\"a}tzliche Bewehrungseinlagen zu erh{\"o}hen. Erste Ergebnisse des Systems IMES f{\"u}r Belastungen in und senkrecht zu der Wandebene werden vorgestellt.}, language = {de} } @article{ButenwegMarinkovićKubalskietal.2018, author = {Butenweg, Christoph and Marinković, Marko and Kubalski, Thomas and Fehling, Ekkehard and Pfetzing, Thomas and Meyer, Udo}, title = {Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk (Teil 2)}, series = {Ziegelindustrie international : ZI = Brick and tile industry international}, journal = {Ziegelindustrie international : ZI = Brick and tile industry international}, number = {6}, editor = {Voss, Michael}, publisher = {Bauverlag BV GmbH}, address = {G{\"u}tersloh}, issn = {0341-0552}, pages = {24 -- 43}, year = {2018}, abstract = {Im Rahmen des europ{\"a}ischen Verbundprojekts INSYSME wurden von den deutschen Partnern die Systeme IMES und INODIS zur Verbesserung des seismischen Verhaltens von ausgefachten Stahlbetonrahmen entwickelt. Ziel beider Systeme ist es, Stahlbetonrahmen und Ausfachung zu entkoppeln, anstatt die Tragf{\"a}higkeit durch aufwendige und kostspielige zus{\"a}tzliche Bewehrungseinlagen zu erh{\"o}hen. Erste Ergebnisse des Systems IMES f{\"u}r Belastungen in und senkrecht zu der Wandebene werden vorgestellt.}, language = {de} } @article{SchwabedalSippelBrandtetal.2018, author = {Schwabedal, Justus T. C. and Sippel, Daniel and Brandt, Moritz D. and Bialonski, Stephan}, title = {Automated Classification of Sleep Stages and EEG Artifacts in Mice with Deep Learning}, doi = {10.48550/arXiv.1809.08443}, year = {2018}, abstract = {Sleep scoring is a necessary and time-consuming task in sleep studies. In animal models (such as mice) or in humans, automating this tedious process promises to facilitate long-term studies and to promote sleep biology as a data-driven f ield. We introduce a deep neural network model that is able to predict different states of consciousness (Wake, Non-REM, REM) in mice from EEG and EMG recordings with excellent scoring results for out-of-sample data. Predictions are made on epochs of 4 seconds length, and epochs are classified as artifactfree or not. The model architecture draws on recent advances in deep learning and in convolutional neural networks research. In contrast to previous approaches towards automated sleep scoring, our model does not rely on manually defined features of the data but learns predictive features automatically. We expect deep learning models like ours to become widely applied in different fields, automating many repetitive cognitive tasks that were previously difficult to tackle.}, language = {en} } @inproceedings{EngemannWiesenKallweitetal.2018, author = {Engemann, Heiko and Wiesen, Patrick and Kallweit, Stephan and Deshpande, Harshavardhan and Schleupen, Josef}, title = {Autonomous mobile manipulation using ROS}, series = {Advances in Service and Industrial Robotics}, booktitle = {Advances in Service and Industrial Robotics}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-61276-8}, doi = {10.1007/978-3-319-61276-8_43}, pages = {389 -- 401}, year = {2018}, language = {en} } @article{KampkerSchleserTriebsetal.2018, author = {Kampker, Achim and Schleser, Markus and Triebs, Johannes and Berg, Alexander-Karl and Hansen, Jan Ole and Fiedler, Falko}, title = {Bauteilintegrierte Vorrichtungsfunktionen im Karosseriebau : Aktuelle Ergebnisse im Forschungsprojekt ProeK}, series = {ZWF Zeitschrift f{\"u}r wirtschaftlichen Fabrikbetrieb}, volume = {113}, journal = {ZWF Zeitschrift f{\"u}r wirtschaftlichen Fabrikbetrieb}, number = {11}, publisher = {De Gruyter}, address = {Berlin}, issn = {0947-0085}, doi = {10.3139/104.112012}, pages = {767 -- 770}, year = {2018}, abstract = {Das Forschungsprojekt Produktionseffizienz in der Kleinserie (ProeK) erarbeitet kosteng{\"u}nstige und effiziente L{\"o}sungsans{\"a}tze f{\"u}r Prozessketten im Zukunftsfeld der Elektromobilit{\"a}t. Das Teilprojekt Karosserie setzt diese Zielsetzung durch innovative und praxisorientierte Produkt- und Prozesskonzepte mit neuartigen bauteilintegrierten Vorrichtungsfunktionen (BiV) um. Im Teilprojekt Außenhaut sollen Toleranzen adaptiv durch Anpassungen der Prozessparameter sowie Bauteilmanipulation kompensiert werden.}, language = {de} } @book{Timme2018, author = {Timme, Michael}, title = {BGB Crashkurs: der sichere Weg durch die Pr{\"u}fung}, edition = {5. Auflage}, publisher = {C.H. Beck}, address = {M{\"u}nchen}, isbn = {978-3-406-72251-6}, pages = {160 Seiten}, year = {2018}, language = {de} } @article{Olbertz2018, author = {Olbertz, Klaus}, title = {Bindung des Betriebserwerbers an zuk{\"u}nftige Tariflohnerh{\"o}hungen : Auswirkungen eines Betriebs{\"u}bergangs auf Bezugnahmeklauseln in {\"u}bernommenen Arbeitsvertr{\"a}gen}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {39}, publisher = {NWB-Verl.}, address = {Herne}, issn = {1860-9449}, pages = {2864 -- 2869}, year = {2018}, language = {de} } @book{ArtmannTemizArtmannZhubanovaetal.2018, author = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, title = {Biological, physical and technical basics of cell engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7903-0}, pages = {xxiv, 481 Seiten ; Illustrationen, Diagramme}, year = {2018}, language = {en} } @inproceedings{KahmannUschokWegmannetal.2018, author = {Kahmann, Stephanie Lucina and Uschok, Stephan and Wegmann, Kilian and M{\"u}ller, Lars-P. and Staat, Manfred}, title = {Biomechanical multibody model with refined kinematics of the elbow}, series = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, booktitle = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, pages = {11 Seiten}, year = {2018}, abstract = {The overall objective of this study is to develop a new external fixator, which closely maps the native kinematics of the elbow to decrease the joint force resulting in reduced rehabilitation time and pain. An experimental setup was designed to determine the native kinematics of the elbow during flexion of cadaveric arms. As a preliminary study, data from literature was used to modify a published biomechanical model for the calculation of the joint and muscle forces. They were compared to the original model and the effect of the kinematic refinement was evaluated. Furthermore, the obtained muscle forces were determined in order to apply them in the experimental setup. The joint forces in the modified model differed slightly from the forces in the original model. The muscle force curves changed particularly for small flexion angles but their magnitude for larger angles was consistent.}, language = {en} }