@incollection{WolfKapelyukhScheeretal.2015, author = {Wolf, C. Roland and Kapelyukh, Yury and Scheer, Nico and Henderson, Colin J.}, title = {Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs}, editor = {Wilson, Alan G. E.}, publisher = {RSC Publ.}, address = {Cambridge}, isbn = {978-1-78262-778-4}, doi = {10.1039/9781782622376-00152}, pages = {152 -- 176}, year = {2015}, abstract = {The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.}, language = {en} } @article{WittmannUlamecFeuerbacheretal.1997, author = {Wittmann, Klaus and Ulamec, S. and Feuerbacher, B. and Rosenbauer, H. (u.a.)}, title = {Rosetta Lander - In Situ Investigation of a Cometary Nucleus}, series = {Lunar and Planetary Science. 28 (1997)}, journal = {Lunar and Planetary Science. 28 (1997)}, isbn = {0270-9511}, pages = {1461 -- 1462}, year = {1997}, language = {en} } @article{WittmannUlamecFeuerbacheretal.1995, author = {Wittmann, Klaus and Ulamec, S. and Feuerbacher, B. and Rosenbauer, H.}, title = {Technical Challenge, Scientific Thrill: A Long Term Lander on an Active Comet}, series = {Lunar and Planetary Science. 26 (1995)}, journal = {Lunar and Planetary Science. 26 (1995)}, isbn = {0270-9511}, pages = {1431 -- 1432}, year = {1995}, language = {en} } @article{WittmannUlamecRichter1999, author = {Wittmann, Klaus and Ulamec, S and Richter, L}, title = {Lander Systems for Planetary Missions}, series = {Laboratory astrophysics and space research / ed. by P. Ehrenfreund}, journal = {Laboratory astrophysics and space research / ed. by P. Ehrenfreund}, publisher = {Kluwer}, address = {Dordrecht [u.a.]}, isbn = {0-7923-5338-2}, pages = {597 -- 621}, year = {1999}, language = {en} } @article{WittmannSchmidtPadekenetal.1988, author = {Wittmann, Klaus and Schmidt, H. P. and Padeken, D. and Hildmann, B.}, title = {The Microgravity User Support Centre (MUSC)}, series = {ESA SP. 277 (1988)}, journal = {ESA SP. 277 (1988)}, isbn = {0379-6566}, pages = {525}, year = {1988}, language = {en} } @article{WittmannSchmidtFeuerbacher1988, author = {Wittmann, Klaus and Schmidt, H. P. and Feuerbacher, B.}, title = {Microgravity research and user support in the Space Station era: The Microgravity User Support Centre}, series = {Acta Astronautica. 17 (1988), H. 11-12}, journal = {Acta Astronautica. 17 (1988), H. 11-12}, isbn = {0094-5765}, pages = {1161 -- 1168}, year = {1988}, language = {en} } @article{WittmannPadeken1993, author = {Wittmann, Klaus and Padeken, D.}, title = {The User Center for Microgravity MUSC - Support for space experiments}, series = {DLR-Nachrichten. 70 (1993)}, journal = {DLR-Nachrichten. 70 (1993)}, isbn = {0937-0420}, pages = {19 -- 24}, year = {1993}, language = {en} } @article{WittmannKellWinkleretal.1998, author = {Wittmann, Klaus and Kell, G. and Winkler, F. and G{\"u}nther, M. (u.a.)}, title = {High resolution temperature measurement technique for materials sciences experiments in space}, series = {Acta Astronautica. 43 (1998), H. 7-8}, journal = {Acta Astronautica. 43 (1998), H. 7-8}, isbn = {0094-5765}, pages = {385 -- 395}, year = {1998}, language = {en} } @article{WittmannKehrWillnecker2000, author = {Wittmann, Klaus and Kehr, J. and Willnecker, R.}, title = {Decentralized Payload Operations Concept for Columbus}, year = {2000}, language = {en} } @article{WittmannGillessenOttoetal.1996, author = {Wittmann, Klaus and Gillessen, F. and Otto, G. and R{\"o}stel, R.}, title = {Undercooling and solidification of metallic melts suspended in a non-nucleating matrix: Experiment NUCAL of the German Spacelab Mission D-2}, series = {Acta Astronautica. 38 (1996), H. 1}, journal = {Acta Astronautica. 38 (1996), H. 1}, isbn = {0094-5765}, pages = {63 -- 68}, year = {1996}, language = {en} }